               SEQUENCE LISTING

<110> Apogenix AG

<120> SINGLE-CHAIN GITR-RECEPTOR AGONIST PROTEINS

<130> SeqListingSCGITRL

<160> 50

<170> BiSSAP 1.3.6

<210> 1
<211> 177
<212> PRT
<213> Homo sapiens


<220> 
<223> GITR Ligand WT

<400> 1
Met Cys Leu Ser His Leu Glu Asn Met Pro Leu Ser His Ser Arg Thr 
1               5                   10                  15      
Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu Trp Leu Phe Cys Ser Ile 
            20                  25                  30          
Val Met Leu Leu Phe Leu Cys Ser Phe Ser Trp Leu Ile Phe Ile Phe 
        35                  40                  45              
Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro 
    50                  55                  60                  
Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn 
65                  70                  75                  80  
Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu 
                85                  90                  95      
Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro 
            100                 105                 110         
Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr 
        115                 120                 125             
Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val 
    130                 135                 140                 
Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys 
145                 150                 155                 160 
Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile 
                165                 170                 175     
Ser 
    

<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 2
Gly Ser Gly Ser Gly Asn Gly Ser 
1               5               

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 3
Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 4
Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 5
Gly Gly Ser Gly Ser Gly 
1               5       

<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 6
Gly Gly Ser Gly 
1               

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 7
Gly Gly Ser Gly Asn Gly Ser Gly 
1               5               

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 8
Gly Gly Asn Gly Ser Gly Ser Gly 
1               5               

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 9
Gly Gly Asn Gly Ser Gly 
1               5       

<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 10
Gly Ser Gly Ser Gly Ser 
1               5       

<210> 11
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 11
Gly Ser Gly Ser 
1               

<210> 12
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 12
Gly Ser Gly 
1           

<210> 13
<211> 218
<212> PRT
<213> Artificial Sequence


<220> 
<223> IGG1-Fc N297S

<400> 13
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        35                  40                  45              
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             

<210> 14
<211> 217
<212> PRT
<213> Artificial Sequence


<220> 
<223> IGG1-Fc WT

<400> 14
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         

<210> 15
<211> 667
<212> PRT
<213> Artificial Sequence


<220> 
<223> PROT A (GITRL Deglyco Fc)

<400> 15
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly 
            20                  25                  30          
Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val 
        35                  40                  45              
Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr 
    50                  55                  60                  
Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala 
65                  70                  75                  80  
Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu 
                85                  90                  95      
Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His 
            100                 105                 110         
Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu 
        115                 120                 125             
Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe 
    130                 135                 140                 
Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys Glu Pro 
145                 150                 155                 160 
Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser 
                165                 170                 175     
Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile 
            180                 185                 190         
Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala 
        195                 200                 205             
Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys 
    210                 215                 220                 
Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly 
225                 230                 235                 240 
Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn 
                245                 250                 255     
Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu 
            260                 265                 270         
Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser 
        275                 280                 285             
Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
    290                 295                 300                 
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
305                 310                 315                 320 
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
                325                 330                 335     
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
            340                 345                 350         
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
        355                 360                 365             
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
    370                 375                 380                 
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
385                 390                 395                 400 
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
                405                 410                 415     
Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys 
            420                 425                 430         
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     
Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser Ser 
                645                 650                 655     
Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            660                 665         

<210> 16
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 16
Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His 
1               5                   10                  15      
Thr Cys Pro Pro Cys 
            20      

<210> 17
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> universal signal peptide

<400> 17
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly 
            20  

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> serine linker with strep tag

<400> 18
Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10                  15  

<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 19
Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr 
1               5                   10                  15      
Cys Pro Pro Cys 
            20  

<210> 20
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 20
Gly Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      
Pro Pro Cys 
            

<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 21
Gly Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      
Pro Cys 
        

<210> 22
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 22
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      



<210> 23
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 23
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      
Gly Ser 
        

<210> 24
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 24
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      
Gly Ser Gly Ser 
            20  

<210> 25
<211> 653
<212> PRT
<213> Artificial Sequence


<220> 
<223> PROTEIN A - no strep tag

<400> 25
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly 
            20                  25                  30          
Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val 
        35                  40                  45              
Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr 
    50                  55                  60                  
Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala 
65                  70                  75                  80  
Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu 
                85                  90                  95      
Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His 
            100                 105                 110         
Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu 
        115                 120                 125             
Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe 
    130                 135                 140                 
Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys Glu Pro 
145                 150                 155                 160 
Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser 
                165                 170                 175     
Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile 
            180                 185                 190         
Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala 
        195                 200                 205             
Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys 
    210                 215                 220                 
Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly 
225                 230                 235                 240 
Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn 
                245                 250                 255     
Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu 
            260                 265                 270         
Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser 
        275                 280                 285             
Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
    290                 295                 300                 
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
305                 310                 315                 320 
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
                325                 330                 335     
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
            340                 345                 350         
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
        355                 360                 365             
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
    370                 375                 380                 
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
385                 390                 395                 400 
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
                405                 410                 415     
Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys 
            420                 425                 430         
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        435                 440                 445             
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    450                 455                 460                 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
465                 470                 475                 480 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                485                 490                 495     
Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 
            500                 505                 510         
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        515                 520                 525             
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    530                 535                 540                 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
545                 550                 555                 560 
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                565                 570                 575     
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            580                 585                 590         
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        595                 600                 605             
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    610                 615                 620                 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
625                 630                 635                 640 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650             

<210> 26
<211> 652
<212> PRT
<213> Artificial Sequence


<220> 
<223> GITRL-wt fused to Seq_14

<400> 26
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly 
            20                  25                  30          
Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val 
        35                  40                  45              
Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr 
    50                  55                  60                  
Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala 
65                  70                  75                  80  
Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu 
                85                  90                  95      
Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His 
            100                 105                 110         
Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu 
        115                 120                 125             
Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe 
    130                 135                 140                 
Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys Glu Pro 
145                 150                 155                 160 
Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser 
                165                 170                 175     
Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile 
            180                 185                 190         
Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala 
        195                 200                 205             
Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys 
    210                 215                 220                 
Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly 
225                 230                 235                 240 
Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn 
                245                 250                 255     
Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu 
            260                 265                 270         
Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser 
        275                 280                 285             
Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
    290                 295                 300                 
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
305                 310                 315                 320 
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
                325                 330                 335     
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
            340                 345                 350         
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
        355                 360                 365             
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
    370                 375                 380                 
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
385                 390                 395                 400 
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
                405                 410                 415     
Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys 
            420                 425                 430         
Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
        435                 440                 445             
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    450                 455                 460                 
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
465                 470                 475                 480 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                485                 490                 495     
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            500                 505                 510         
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        515                 520                 525             
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    530                 535                 540                 
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
545                 550                 555                 560 
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                565                 570                 575     
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            580                 585                 590         
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        595                 600                 605             
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    610                 615                 620                 
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
625                 630                 635                 640 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650         

<210> 27
<211> 633
<212> PRT
<213> Artificial Sequence


<220> 
<223> GITRL-wt fused to Seq_13 (no sig, no strep tag, no glyco)

<400> 27
Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
1               5                   10                  15      
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
            20                  25                  30          
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
        35                  40                  45              
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
    50                  55                  60                  
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
65                  70                  75                  80  
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
                85                  90                  95      
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
            100                 105                 110         
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
        115                 120                 125             
Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys Glu Pro Cys Met Ala Lys 
    130                 135                 140                 
Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro 
145                 150                 155                 160 
Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly 
                165                 170                 175     
Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp 
            180                 185                 190         
Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln 
        195                 200                 205             
Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu 
    210                 215                 220                 
Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln 
225                 230                 235                 240 
Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro 
                245                 250                 255     
Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys 
            260                 265                 270         
Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
        275                 280                 285             
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
    290                 295                 300                 
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
305                 310                 315                 320 
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
                325                 330                 335     
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
            340                 345                 350         
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
        355                 360                 365             
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
    370                 375                 380                 
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Ser Ser Ser Ser 
385                 390                 395                 400 
Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                405                 410                 415     
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            420                 425                 430         
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        435                 440                 445             
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    450                 455                 460                 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
465                 470                 475                 480 
Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                485                 490                 495     
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            500                 505                 510         
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        515                 520                 525             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    530                 535                 540                 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
545                 550                 555                 560 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                565                 570                 575     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            580                 585                 590         
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        595                 600                 605             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    610                 615                 620                 
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630             

<210> 28
<211> 647
<212> PRT
<213> Artificial Sequence


<220> 
<223> GITRL-wt fused to Seq_13 (no sig, no glyco)

<400> 28
Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
1               5                   10                  15      
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
            20                  25                  30          
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
        35                  40                  45              
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
    50                  55                  60                  
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
65                  70                  75                  80  
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
                85                  90                  95      
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
            100                 105                 110         
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
        115                 120                 125             
Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys Glu Pro Cys Met Ala Lys 
    130                 135                 140                 
Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro 
145                 150                 155                 160 
Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly 
                165                 170                 175     
Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp 
            180                 185                 190         
Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln 
        195                 200                 205             
Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu 
    210                 215                 220                 
Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln 
225                 230                 235                 240 
Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro 
                245                 250                 255     
Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys 
            260                 265                 270         
Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
        275                 280                 285             
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
    290                 295                 300                 
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
305                 310                 315                 320 
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
                325                 330                 335     
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
            340                 345                 350         
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
        355                 360                 365             
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
    370                 375                 380                 
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Ser Ser Ser Ser 
385                 390                 395                 400 
Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                405                 410                 415     
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            420                 425                 430         
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        435                 440                 445             
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    450                 455                 460                 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
465                 470                 475                 480 
Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                485                 490                 495     
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            500                 505                 510         
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        515                 520                 525             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    530                 535                 540                 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
545                 550                 555                 560 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                565                 570                 575     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            580                 585                 590         
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        595                 600                 605             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    610                 615                 620                 
Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser Ser Ser Ser Ala Trp 
625                 630                 635                 640 
Ser His Pro Gln Phe Glu Lys 
                645         

<210> 29
<211> 632
<212> PRT
<213> Artificial Sequence


<220> 
<223> GITRL-wt fused to Seq14 (no sig, no strep tag)

<400> 29
Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
1               5                   10                  15      
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
            20                  25                  30          
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
        35                  40                  45              
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
    50                  55                  60                  
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
65                  70                  75                  80  
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
                85                  90                  95      
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
            100                 105                 110         
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
        115                 120                 125             
Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys Glu Pro Cys Met Ala Lys 
    130                 135                 140                 
Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro 
145                 150                 155                 160 
Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly 
                165                 170                 175     
Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp 
            180                 185                 190         
Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln 
        195                 200                 205             
Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu 
    210                 215                 220                 
Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln 
225                 230                 235                 240 
Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro 
                245                 250                 255     
Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys 
            260                 265                 270         
Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
        275                 280                 285             
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
    290                 295                 300                 
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
305                 310                 315                 320 
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
                325                 330                 335     
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
            340                 345                 350         
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
        355                 360                 365             
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
    370                 375                 380                 
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Ser Ser Ser Ser 
385                 390                 395                 400 
Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                405                 410                 415     
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            420                 425                 430         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        435                 440                 445             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    450                 455                 460                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
465                 470                 475                 480 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                485                 490                 495     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            500                 505                 510         
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        515                 520                 525             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    530                 535                 540                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
545                 550                 555                 560 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                565                 570                 575     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            580                 585                 590         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        595                 600                 605             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    610                 615                 620                 
Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630         

<210> 30
<211> 633
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 30
Gln Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
1               5                   10                  15      
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
            20                  25                  30          
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
        35                  40                  45              
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
    50                  55                  60                  
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
65                  70                  75                  80  
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
                85                  90                  95      
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
            100                 105                 110         
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
        115                 120                 125             
Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys Glu Pro Cys Met Ala Lys 
    130                 135                 140                 
Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro 
145                 150                 155                 160 
Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly 
                165                 170                 175     
Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp 
            180                 185                 190         
Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln 
        195                 200                 205             
Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu 
    210                 215                 220                 
Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln 
225                 230                 235                 240 
Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro 
                245                 250                 255     
Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys 
            260                 265                 270         
Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
        275                 280                 285             
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
    290                 295                 300                 
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
305                 310                 315                 320 
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
                325                 330                 335     
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
            340                 345                 350         
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
        355                 360                 365             
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
    370                 375                 380                 
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Ser Ser Ser Ser 
385                 390                 395                 400 
Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                405                 410                 415     
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            420                 425                 430         
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        435                 440                 445             
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    450                 455                 460                 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
465                 470                 475                 480 
Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                485                 490                 495     
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            500                 505                 510         
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        515                 520                 525             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    530                 535                 540                 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
545                 550                 555                 560 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                565                 570                 575     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            580                 585                 590         
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        595                 600                 605             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    610                 615                 620                 
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630             

<210> 31
<211> 619
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 31
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn 
        115                 120                 125             
Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln 
    130                 135                 140                 
Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys 
145                 150                 155                 160 
Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala 
                165                 170                 175     
Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr 
            180                 185                 190         
Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln 
        195                 200                 205             
Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu 
    210                 215                 220                 
Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly 
225                 230                 235                 240 
Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly 
                245                 250                 255     
Asn Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp 
            260                 265                 270         
Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp 
        275                 280                 285             
Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val 
    290                 295                 300                 
Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu 
305                 310                 315                 320 
Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile 
                325                 330                 335     
Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp 
            340                 345                 350         
Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp 
        355                 360                 365             
Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Ser Ser 
    370                 375                 380                 
Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
385                 390                 395                 400 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                405                 410                 415     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            420                 425                 430         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        435                 440                 445             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    450                 455                 460                 
Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
465                 470                 475                 480 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                485                 490                 495     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            500                 505                 510         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        515                 520                 525             
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    530                 535                 540                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
545                 550                 555                 560 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                565                 570                 575     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            580                 585                 590         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        595                 600                 605             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 

<210> 32
<211> 618
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 32
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn 
        115                 120                 125             
Gly Ser Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp 
    130                 135                 140                 
Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp 
145                 150                 155                 160 
Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val 
                165                 170                 175     
Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu 
            180                 185                 190         
Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile 
        195                 200                 205             
Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp 
    210                 215                 220                 
Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp 
225                 230                 235                 240 
Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser 
                245                 250                 255     
Gly Asn Gly Ser Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
            260                 265                 270         
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
        275                 280                 285             
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
    290                 295                 300                 
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
305                 310                 315                 320 
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
                325                 330                 335     
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
            340                 345                 350         
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
        355                 360                 365             
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
    370                 375                 380                 
Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
385                 390                 395                 400 
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                405                 410                 415     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            420                 425                 430         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        435                 440                 445             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    450                 455                 460                 
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
465                 470                 475                 480 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                485                 490                 495     
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            500                 505                 510         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        515                 520                 525             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    530                 535                 540                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
545                 550                 555                 560 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                565                 570                 575     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            580                 585                 590         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        595                 600                 605             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615             

<210> 33
<211> 601
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 33
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Gly Ser Gly Ser Gly Asn Gly Ser Pro Cys Met Ala 
        115                 120                 125             
Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro 
    130                 135                 140                 
Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn 
145                 150                 155                 160 
Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn 
                165                 170                 175     
Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile 
            180                 185                 190         
Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr 
        195                 200                 205             
Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His 
    210                 215                 220                 
Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Gly 
225                 230                 235                 240 
Ser Gly Ser Gly Asn Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu 
                245                 250                 255     
Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys 
            260                 265                 270         
Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile 
        275                 280                 285             
Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe 
    290                 295                 300                 
Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn 
305                 310                 315                 320 
Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly 
                325                 330                 335     
Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn 
            340                 345                 350         
Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Gly Ser Ser Ser Ser Ser 
        355                 360                 365             
Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    370                 375                 380                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
385                 390                 395                 400 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                405                 410                 415     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            420                 425                 430         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        435                 440                 445             
Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    450                 455                 460                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
465                 470                 475                 480 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                485                 490                 495     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            500                 505                 510         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        515                 520                 525             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    530                 535                 540                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
545                 550                 555                 560 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                565                 570                 575     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            580                 585                 590         
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600     

<210> 34
<211> 624
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 34
Gln Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln 
1               5                   10                  15      
Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys 
            20                  25                  30          
Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala 
        35                  40                  45              
Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr 
    50                  55                  60                  
Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln 
65                  70                  75                  80  
Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu 
                85                  90                  95      
Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly 
            100                 105                 110         
Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly 
        115                 120                 125             
Asn Gly Ser Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
    130                 135                 140                 
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
145                 150                 155                 160 
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
                165                 170                 175     
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
            180                 185                 190         
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
        195                 200                 205             
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
    210                 215                 220                 
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
225                 230                 235                 240 
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
                245                 250                 255     
Gly Ser Gly Asn Gly Ser Lys Glu Pro Cys Met Ala Lys Phe Gly Pro 
            260                 265                 270         
Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn 
        275                 280                 285             
Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu 
    290                 295                 300                 
Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro 
305                 310                 315                 320 
Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr 
                325                 330                 335     
Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val 
            340                 345                 350         
Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys 
        355                 360                 365             
Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile 
    370                 375                 380                 
Ser Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr 
385                 390                 395                 400 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                405                 410                 415     
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            420                 425                 430         
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        435                 440                 445             
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    450                 455                 460                 
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val 
465                 470                 475                 480 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                485                 490                 495     
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            500                 505                 510         
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        515                 520                 525             
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    530                 535                 540                 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
545                 550                 555                 560 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                565                 570                 575     
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            580                 585                 590         
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        595                 600                 605             
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620                 



<210> 35
<211> 609
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 35
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Asn Pro Gln Gly Ser Gly Ser Gly Asn Gly Ser Pro 
        115                 120                 125             
Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser 
    130                 135                 140                 
Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile 
145                 150                 155                 160 
Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala 
                165                 170                 175     
Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys 
            180                 185                 190         
Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly 
        195                 200                 205             
Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn 
    210                 215                 220                 
Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu 
225                 230                 235                 240 
Leu Ala Asn Pro Gly Ser Gly Ser Gly Asn Gly Ser Pro Cys Met Ala 
                245                 250                 255     
Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro 
            260                 265                 270         
Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn 
        275                 280                 285             
Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn 
    290                 295                 300                 
Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile 
305                 310                 315                 320 
Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr 
                325                 330                 335     
Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His 
            340                 345                 350         
Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn 
        355                 360                 365             
Pro Gln Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys 
    370                 375                 380                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
385                 390                 395                 400 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                405                 410                 415     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            420                 425                 430         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        435                 440                 445             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val 
    450                 455                 460                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
465                 470                 475                 480 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                485                 490                 495     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            500                 505                 510         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        515                 520                 525             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    530                 535                 540                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
545                 550                 555                 560 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                565                 570                 575     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            580                 585                 590         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        595                 600                 605             
Lys 
    

<210> 36
<211> 394
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 36
Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
1               5                   10                  15      
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
            20                  25                  30          
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
        35                  40                  45              
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
    50                  55                  60                  
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
65                  70                  75                  80  
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
                85                  90                  95      
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
            100                 105                 110         
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
        115                 120                 125             
Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys Glu Pro Cys Met Ala Lys 
    130                 135                 140                 
Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro 
145                 150                 155                 160 
Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly 
                165                 170                 175     
Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp 
            180                 185                 190         
Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln 
        195                 200                 205             
Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu 
    210                 215                 220                 
Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln 
225                 230                 235                 240 
Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro 
                245                 250                 255     
Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys 
            260                 265                 270         
Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
        275                 280                 285             
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
    290                 295                 300                 
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
305                 310                 315                 320 
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
                325                 330                 335     
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
            340                 345                 350         
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
        355                 360                 365             
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
    370                 375                 380                 
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
385                 390                 

<210> 37
<211> 2006
<212> DNA
<213> Artificial Sequence


<220> 
<223> nucl. acid sequence of GITR receptor agonist fusion protein

<400> 37
aagctttagg gataacaggg taatagccgc caccatggag actgacaccc tgctggtgtt      60

cgtgctgctg gtctgggtgc ctgcaggaaa tggagaaact gccaaagagc cctgtatggc     120

caagtttggc cctcttccct ctaagtggca gatggcttcc tctgaaccac catgcgtgaa     180

caaagtgagc gactggaaac tggagatctt gcagaacggg ctgtatttga tctacggcca     240

ggtggcccct aatgctaact ataacgatgt agccccattt gaggtcagac tgtataagaa     300

taaggacatg attcagactc tgaccaataa gtccaagatc cagaatgtgg gaggcactta     360

cgaattgcac gtgggtgata ccatcgattt gatcttcaac agcgaacatc aggtgctcaa     420

gaacaataca tactggggaa ttatactgct ggcaaaccca cagttcattt ccgggtccgg     480

ttctggtaac ggctctgaga cagcaaaaga gccctgcatg gcaaaattcg gtcctctgcc     540

cagtaagtgg caaatggcat catccgaacc tccctgtgtg aataaggtgt cagactggaa     600

acttgagatc cttcagaatg gactctacct catctatgga caggttgctc ctaacgctaa     660

ttacaatgat gtggctccct tcgaagttcg gctgtacaag aataaggata tgatacagac     720

ccttactaac aaaagcaaaa ttcagaacgt gggcggaaca tacgagctgc atgtcggtga     780

cacgattgat ctgatcttca actcagagca tcaggtcctg aagaataaca cctactgggg     840

cattattctg ctcgccaatc cccaatttat atccgggagc gggtcaggca acggcagtga     900

gacagccaag gaaccatgta tggctaaatt tgggcccctg ccatctaaat ggcagatggc     960

atctagcgaa cctccctgcg ttaacaaggt atccgactgg aaattggaga tcctccagaa    1020

cggactgtac ctgatctatg gccaagtcgc cccaaatgcc aattacaatg acgtagctcc    1080

ctttgaggtc aggctctata agaacaaaga catgattcaa acacttacca acaagagtaa    1140

gatacagaat gtgggcggaa cctatgaact gcacgttggg gataccattg acctgatctt    1200

caacagtgag caccaagtcc tcaagaataa cacttattgg ggtatcatcc tgctggccaa    1260

ccctcagttt atcagcggat cctcgagttc atcgtcctca tccggctcat gtgataagac    1320

ccacacctgc cctccctgtc ctgcccctga gctgctgggc ggaccttctg tgttcctgtt    1380

cccccccaag cctaaggaca ccctgatgat ctccaggacc cctgaggtga cctgtgtggt    1440

ggtggacgtg tctcacgaag atcccgaggt gaagttcaac tggtacgtgg acggcgtgga    1500

ggtccacaac gccaagacca agcctaggga ggagcagtac agctccacct accgggtggt    1560

gtctgtgctg accgtgctgc accaggattg gctgaacgga aaggagtata agtgtaaggt    1620

ctccaacaag gccctgcctg cccccatcga gaaaaccatc tccaaggcca agggccagcc    1680

tcgggagcct caggtgtaca ccctgcctcc tagcagggag gagatgacca agaaccaggt    1740

gtccctgacc tgtctggtga agggcttcta cccttccgat atcgccgtgg agtgggagtc    1800

taatggccag cccgagaaca actacaagac cacccctcct gtgctggact ctgacggctc    1860

cttcttcctg tactccaagc tgaccgtgga caagtccaga tggcagcagg gcaacgtgtt    1920

ctcctgctcc gtgatgcacg aggccctgca caatcactac acccagaagt ccctgtctct    1980

gagtccgggc aagtaatagg cgcgcc                                         2006


<210> 38
<211> 203
<212> PRT
<213> Artificial Sequence


<220> 
<223> GITRL fused to RB69 FOLDON

<400> 38
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly 
            20                  25                  30          
Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val 
        35                  40                  45              
Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr 
    50                  55                  60                  
Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala 
65                  70                  75                  80  
Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu 
                85                  90                  95      
Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His 
            100                 105                 110         
Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu 
        115                 120                 125             
Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe 
    130                 135                 140                 
Ile Ser Gly Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Gly 
145                 150                 155                 160 
Tyr Ile Glu Asp Ala Pro Ser Asp Gly Lys Phe Tyr Val Arg Lys Asp 
                165                 170                 175     
Gly Ala Trp Val Glu Leu Pro Thr Ala Ser Gly Pro Ser Ser Ser Ser 
            180                 185                 190         
Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        195                 200             

<210> 39
<211> 394
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 39
Gln Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
1               5                   10                  15      
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
            20                  25                  30          
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
        35                  40                  45              
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
    50                  55                  60                  
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
65                  70                  75                  80  
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
                85                  90                  95      
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
            100                 105                 110         
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
        115                 120                 125             
Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys Glu Pro Cys Met Ala Lys 
    130                 135                 140                 
Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro 
145                 150                 155                 160 
Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly 
                165                 170                 175     
Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp 
            180                 185                 190         
Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln 
        195                 200                 205             
Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu 
    210                 215                 220                 
Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln 
225                 230                 235                 240 
Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro 
                245                 250                 255     
Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn Gly Ser Glu Thr Ala Lys 
            260                 265                 270         
Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
        275                 280                 285             
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
    290                 295                 300                 
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
305                 310                 315                 320 
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
                325                 330                 335     
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
            340                 345                 350         
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
        355                 360                 365             
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
    370                 375                 380                 
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
385                 390                 

<210> 40
<211> 382
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 40
Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn 
        115                 120                 125             
Gly Ser Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp 
    130                 135                 140                 
Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp 
145                 150                 155                 160 
Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val 
                165                 170                 175     
Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu 
            180                 185                 190         
Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile 
        195                 200                 205             
Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp 
    210                 215                 220                 
Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp 
225                 230                 235                 240 
Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser 
                245                 250                 255     
Gly Asn Gly Ser Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
            260                 265                 270         
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
        275                 280                 285             
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
    290                 295                 300                 
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
305                 310                 315                 320 
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
                325                 330                 335     
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
            340                 345                 350         
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
        355                 360                 365             
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
    370                 375                 380         

<210> 41
<211> 382
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 41
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn 
        115                 120                 125             
Gly Ser Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp 
    130                 135                 140                 
Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp 
145                 150                 155                 160 
Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val 
                165                 170                 175     
Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu 
            180                 185                 190         
Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile 
        195                 200                 205             
Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp 
    210                 215                 220                 
Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp 
225                 230                 235                 240 
Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser 
                245                 250                 255     
Gly Asn Gly Ser Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
            260                 265                 270         
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
        275                 280                 285             
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
    290                 295                 300                 
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
305                 310                 315                 320 
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
                325                 330                 335     
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
            340                 345                 350         
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
        355                 360                 365             
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
    370                 375                 380         

<210> 42
<211> 385
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 42
Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln 
1               5                   10                  15      
Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys 
            20                  25                  30          
Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala 
        35                  40                  45              
Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr 
    50                  55                  60                  
Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln 
65                  70                  75                  80  
Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu 
                85                  90                  95      
Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly 
            100                 105                 110         
Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly 
        115                 120                 125             
Asn Gly Ser Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
    130                 135                 140                 
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
145                 150                 155                 160 
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
                165                 170                 175     
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
            180                 185                 190         
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
        195                 200                 205             
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
    210                 215                 220                 
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
225                 230                 235                 240 
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
                245                 250                 255     
Gly Ser Gly Asn Gly Ser Lys Glu Pro Cys Met Ala Lys Phe Gly Pro 
            260                 265                 270         
Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn 
        275                 280                 285             
Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu 
    290                 295                 300                 
Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro 
305                 310                 315                 320 
Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr 
                325                 330                 335     
Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val 
            340                 345                 350         
Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys 
        355                 360                 365             
Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile 
    370                 375                 380                 
Ser 
385 

<210> 43
<211> 385
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 43
Gln Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln 
1               5                   10                  15      
Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys 
            20                  25                  30          
Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala 
        35                  40                  45              
Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr 
    50                  55                  60                  
Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln 
65                  70                  75                  80  
Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu 
                85                  90                  95      
Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly 
            100                 105                 110         
Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly 
        115                 120                 125             
Asn Gly Ser Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
    130                 135                 140                 
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
145                 150                 155                 160 
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
                165                 170                 175     
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
            180                 185                 190         
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
        195                 200                 205             
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
    210                 215                 220                 
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
225                 230                 235                 240 
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
                245                 250                 255     
Gly Ser Gly Asn Gly Ser Lys Glu Pro Cys Met Ala Lys Phe Gly Pro 
            260                 265                 270         
Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn 
        275                 280                 285             
Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu 
    290                 295                 300                 
Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro 
305                 310                 315                 320 
Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr 
                325                 330                 335     
Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val 
            340                 345                 350         
Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys 
        355                 360                 365             
Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile 
    370                 375                 380                 
Ser 
385 

<210> 44
<211> 380
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 44
Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn 
        115                 120                 125             
Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln 
    130                 135                 140                 
Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys 
145                 150                 155                 160 
Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala 
                165                 170                 175     
Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr 
            180                 185                 190         
Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln 
        195                 200                 205             
Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu 
    210                 215                 220                 
Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly 
225                 230                 235                 240 
Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly 
                245                 250                 255     
Asn Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp 
            260                 265                 270         
Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp 
        275                 280                 285             
Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val 
    290                 295                 300                 
Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu 
305                 310                 315                 320 
Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile 
                325                 330                 335     
Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp 
            340                 345                 350         
Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp 
        355                 360                 365             
Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
    370                 375                 380 

<210> 45
<211> 380
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 45
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn 
        115                 120                 125             
Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln 
    130                 135                 140                 
Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys 
145                 150                 155                 160 
Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala 
                165                 170                 175     
Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr 
            180                 185                 190         
Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln 
        195                 200                 205             
Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu 
    210                 215                 220                 
Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly 
225                 230                 235                 240 
Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly 
                245                 250                 255     
Asn Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp 
            260                 265                 270         
Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp 
        275                 280                 285             
Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val 
    290                 295                 300                 
Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu 
305                 310                 315                 320 
Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile 
                325                 330                 335     
Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp 
            340                 345                 350         
Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp 
        355                 360                 365             
Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
    370                 375                 380 

<210> 46
<211> 362
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 46
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Gly Ser Gly Ser Gly Asn Gly Ser Pro Cys Met Ala 
        115                 120                 125             
Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro 
    130                 135                 140                 
Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn 
145                 150                 155                 160 
Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn 
                165                 170                 175     
Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile 
            180                 185                 190         
Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr 
        195                 200                 205             
Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His 
    210                 215                 220                 
Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Gly 
225                 230                 235                 240 
Ser Gly Ser Gly Asn Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu 
                245                 250                 255     
Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys 
            260                 265                 270         
Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile 
        275                 280                 285             
Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe 
    290                 295                 300                 
Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn 
305                 310                 315                 320 
Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly 
                325                 330                 335     
Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn 
            340                 345                 350         
Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala 
        355                 360         

<210> 47
<211> 370
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 47
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Asn Pro Gln Gly Ser Gly Ser Gly Asn Gly Ser Pro 
        115                 120                 125             
Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser 
    130                 135                 140                 
Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile 
145                 150                 155                 160 
Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala 
                165                 170                 175     
Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys 
            180                 185                 190         
Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly 
        195                 200                 205             
Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn 
    210                 215                 220                 
Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu 
225                 230                 235                 240 
Leu Ala Asn Pro Gly Ser Gly Ser Gly Asn Gly Ser Pro Cys Met Ala 
                245                 250                 255     
Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro 
            260                 265                 270         
Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn 
        275                 280                 285             
Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn 
    290                 295                 300                 
Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile 
305                 310                 315                 320 
Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr 
                325                 330                 335     
Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His 
            340                 345                 350         
Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn 
        355                 360                 365             
Pro Gln 
    370 

<210> 48
<211> 358
<212> PRT
<213> Artificial Sequence


<220> 
<223> example of scGITRL-RBD

<400> 48
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Gly Ser Gly Ser Gly Asn Gly Ser Pro Cys Met Ala 
        115                 120                 125             
Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro 
    130                 135                 140                 
Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn 
145                 150                 155                 160 
Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn 
                165                 170                 175     
Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile 
            180                 185                 190         
Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr 
        195                 200                 205             
Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His 
    210                 215                 220                 
Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Gly 
225                 230                 235                 240 
Ser Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp 
                245                 250                 255     
Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp 
            260                 265                 270         
Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val 
        275                 280                 285             
Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu 
    290                 295                 300                 
Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile 
305                 310                 315                 320 
Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp 
                325                 330                 335     
Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp 
            340                 345                 350         
Gly Ile Ile Leu Leu Ala 
        355             

<210> 49
<211> 621
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 49
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Asn 
        115                 120                 125             
Gly Ser Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp 
    130                 135                 140                 
Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp 
145                 150                 155                 160 
Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val 
                165                 170                 175     
Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu 
            180                 185                 190         
Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile 
        195                 200                 205             
Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp 
    210                 215                 220                 
Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp 
225                 230                 235                 240 
Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser 
                245                 250                 255     
Gly Asn Gly Ser Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser 
            260                 265                 270         
Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser 
        275                 280                 285             
Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly 
    290                 295                 300                 
Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val 
305                 310                 315                 320 
Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser 
                325                 330                 335     
Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr 
            340                 345                 350         
Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr 
        355                 360                 365             
Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser 
    370                 375                 380                 
Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys 
385                 390                 395                 400 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                405                 410                 415     
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            420                 425                 430         
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        435                 440                 445             
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    450                 455                 460                 
Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 
465                 470                 475                 480 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                485                 490                 495     
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            500                 505                 510         
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        515                 520                 525             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    530                 535                 540                 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
545                 550                 555                 560 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                565                 570                 575     
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            580                 585                 590         
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        595                 600                 605             
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620     

<210> 50
<211> 597
<212> PRT
<213> Artificial Sequence


<220> 
<223> example

<400> 50
Gln Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met 
1               5                   10                  15      
Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu 
            20                  25                  30          
Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro 
        35                  40                  45              
Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys 
    50                  55                  60                  
Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn 
65                  70                  75                  80  
Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile 
                85                  90                  95      
Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile 
            100                 105                 110         
Ile Leu Leu Ala Gly Ser Gly Ser Gly Asn Gly Ser Pro Cys Met Ala 
        115                 120                 125             
Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro 
    130                 135                 140                 
Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn 
145                 150                 155                 160 
Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn 
                165                 170                 175     
Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile 
            180                 185                 190         
Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr 
        195                 200                 205             
Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His 
    210                 215                 220                 
Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Gly 
225                 230                 235                 240 
Ser Gly Ser Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp 
                245                 250                 255     
Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp 
            260                 265                 270         
Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val 
        275                 280                 285             
Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu 
    290                 295                 300                 
Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile 
305                 310                 315                 320 
Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp 
                325                 330                 335     
Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp 
            340                 345                 350         
Gly Ile Ile Leu Leu Ala Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly 
        355                 360                 365             
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    370                 375                 380                 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
385                 390                 395                 400 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                405                 410                 415     
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            420                 425                 430         
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser 
        435                 440                 445             
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    450                 455                 460                 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
465                 470                 475                 480 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                485                 490                 495     
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            500                 505                 510         
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        515                 520                 525             
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    530                 535                 540                 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
545                 550                 555                 560 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                565                 570                 575     
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            580                 585                 590         
Leu Ser Pro Gly Lys 
        595         

