               SEQUENCE LISTING

<110> Apogenix AG

<120> SINGLE-CHAIN LIGHT RECEPTOR AGONIST PROTEINS

<130> scLIGHT-WO

<160> 40

<170> BiSSAP 1.3.6

<210> 1
<211> 240
<212> PRT
<213> Homo sapiens


<220> 
<223> LIGHT ligand (wt)

<400> 1
Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      
Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          
Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              
Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  
Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  
Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      
His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         
Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             
His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 
Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 
Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     
Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         
Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             
Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 
Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 



<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 2
Gly Ser Gly Ser Gly Asn Gly Ser 
1               5               

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 3
Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 4
Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 5
Gly Gly Ser Gly Ser Gly 
1               5       

<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 6
Gly Gly Ser Gly 
1               

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 7
Gly Gly Ser Gly Asn Gly Ser Gly 
1               5               

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 8
Gly Gly Asn Gly Ser Gly Ser Gly 
1               5               

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 9
Gly Gly Asn Gly Ser Gly 
1               5       

<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 10
Gly Ser Gly Ser Gly Ser 
1               5       

<210> 11
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 11
Gly Ser Gly Ser 
1               

<210> 12
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 12
Gly Ser Gly 
1           

<210> 13
<211> 218
<212> PRT
<213> Artificial Sequence


<220> 
<223> human IGG1 Fc N297S

<400> 13
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        35                  40                  45              
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             

<210> 14
<211> 217
<212> PRT
<213> Artificial Sequence


<220> 
<223> human IGG1 Fc (wt)

<400> 14
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         

<210> 15
<211> 729
<212> PRT
<213> Artificial Sequence


<220> 
<223> PROTEIN A (LIGHT ligand fused to deglyco Fc)

<400> 15
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn 
            20                  25                  30          
Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu 
        35                  40                  45              
Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val 
    50                  55                  60                  
Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly 
65                  70                  75                  80  
Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu 
                85                  90                  95      
Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser 
            100                 105                 110         
Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp 
        115                 120                 125             
Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu 
    130                 135                 140                 
Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly 
145                 150                 155                 160 
Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn 
                165                 170                 175     
Gly Ser Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly 
            180                 185                 190         
Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu 
        195                 200                 205             
Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly 
    210                 215                 220                 
Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro 
225                 230                 235                 240 
Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro 
                245                 250                 255     
Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys 
            260                 265                 270         
Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu 
        275                 280                 285             
Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val 
    290                 295                 300                 
Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe 
305                 310                 315                 320 
Gly Ala Phe Met Val Gly Ser Gly Ser Pro Ala Ala His Leu Thr Gly 
                325                 330                 335     
Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
            340                 345                 350         
Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
        355                 360                 365             
Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
    370                 375                 380                 
Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
385                 390                 395                 400 
Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
                405                 410                 415     
Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
            420                 425                 430         
Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
        435                 440                 445             
Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
    450                 455                 460                 
Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser 
465                 470                 475                 480 
Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                485                 490                 495     
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            500                 505                 510         
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        515                 520                 525             
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    530                 535                 540                 
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
545                 550                 555                 560 
Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                565                 570                 575     
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            580                 585                 590         
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        595                 600                 605             
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    610                 615                 620                 
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
625                 630                 635                 640 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                645                 650                 655     
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            660                 665                 670         
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        675                 680                 685             
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    690                 695                 700                 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser Ser Ser Ser 
705                 710                 715                 720 
Ala Trp Ser His Pro Gln Phe Glu Lys 
                725                 

<210> 16
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 16
Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His 
1               5                   10                  15      
Thr Cys Pro Pro Cys 
            20      

<210> 17
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> universal signal peptide

<400> 17
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly 
            20  

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> serine linker with strep tag

<400> 18
Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10                  15  

<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 19
Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr 
1               5                   10                  15      
Cys Pro Pro Cys 
            20  

<210> 20
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 20
Gly Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      
Pro Pro Cys 
            

<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 21
Gly Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      
Pro Cys 
        

<210> 22
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 22
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      



<210> 23
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 23
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      
Gly Ser 
        

<210> 24
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> hinge linker

<400> 24
Gly Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      
Gly Ser Gly Ser 
            20  

<210> 25
<211> 715
<212> PRT
<213> Artificial Sequence


<220> 
<223> PROTEIN A - no strep tag

<400> 25
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn 
            20                  25                  30          
Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu 
        35                  40                  45              
Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val 
    50                  55                  60                  
Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly 
65                  70                  75                  80  
Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu 
                85                  90                  95      
Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser 
            100                 105                 110         
Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp 
        115                 120                 125             
Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu 
    130                 135                 140                 
Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly 
145                 150                 155                 160 
Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn 
                165                 170                 175     
Gly Ser Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly 
            180                 185                 190         
Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu 
        195                 200                 205             
Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly 
    210                 215                 220                 
Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro 
225                 230                 235                 240 
Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro 
                245                 250                 255     
Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys 
            260                 265                 270         
Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu 
        275                 280                 285             
Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val 
    290                 295                 300                 
Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe 
305                 310                 315                 320 
Gly Ala Phe Met Val Gly Ser Gly Ser Pro Ala Ala His Leu Thr Gly 
                325                 330                 335     
Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
            340                 345                 350         
Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
        355                 360                 365             
Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
    370                 375                 380                 
Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
385                 390                 395                 400 
Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
                405                 410                 415     
Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
            420                 425                 430         
Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
        435                 440                 445             
Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
    450                 455                 460                 
Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser 
465                 470                 475                 480 
Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                485                 490                 495     
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            500                 505                 510         
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        515                 520                 525             
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    530                 535                 540                 
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
545                 550                 555                 560 
Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                565                 570                 575     
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            580                 585                 590         
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        595                 600                 605             
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    610                 615                 620                 
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
625                 630                 635                 640 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                645                 650                 655     
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            660                 665                 670         
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        675                 680                 685             
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    690                 695                 700                 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715 

<210> 26
<211> 714
<212> PRT
<213> Artificial Sequence


<220> 
<223> SEQ36 fused to wtFc (incl. signal peptide; no strep tag)

<400> 26
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn 
            20                  25                  30          
Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu 
        35                  40                  45              
Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val 
    50                  55                  60                  
Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly 
65                  70                  75                  80  
Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu 
                85                  90                  95      
Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser 
            100                 105                 110         
Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp 
        115                 120                 125             
Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu 
    130                 135                 140                 
Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly 
145                 150                 155                 160 
Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn 
                165                 170                 175     
Gly Ser Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly 
            180                 185                 190         
Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu 
        195                 200                 205             
Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly 
    210                 215                 220                 
Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro 
225                 230                 235                 240 
Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro 
                245                 250                 255     
Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys 
            260                 265                 270         
Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu 
        275                 280                 285             
Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val 
    290                 295                 300                 
Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe 
305                 310                 315                 320 
Gly Ala Phe Met Val Gly Ser Gly Ser Pro Ala Ala His Leu Thr Gly 
                325                 330                 335     
Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
            340                 345                 350         
Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
        355                 360                 365             
Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
    370                 375                 380                 
Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
385                 390                 395                 400 
Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
                405                 410                 415     
Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
            420                 425                 430         
Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
        435                 440                 445             
Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
    450                 455                 460                 
Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser 
465                 470                 475                 480 
Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                485                 490                 495     
Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            500                 505                 510         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        515                 520                 525             
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    530                 535                 540                 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
545                 550                 555                 560 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                565                 570                 575     
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            580                 585                 590         
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        595                 600                 605             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    610                 615                 620                 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
625                 630                 635                 640 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                645                 650                 655     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            660                 665                 670         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        675                 680                 685             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    690                 695                 700                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 

<210> 27
<211> 695
<212> PRT
<213> Artificial Sequence


<220> 
<223> SEQ36 fused to deglyco-Fc (no strep tag)

<400> 27
Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
305                 310                 315                 320 
Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
                325                 330                 335     
Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
            340                 345                 350         
Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
        355                 360                 365             
Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
    370                 375                 380                 
Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
385                 390                 395                 400 
Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
                405                 410                 415     
Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val 
            420                 425                 430         
Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
        435                 440                 445             
Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser Ser Ser Ser Ser 
    450                 455                 460                 
Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
465                 470                 475                 480 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                485                 490                 495     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            500                 505                 510         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        515                 520                 525             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    530                 535                 540                 
Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
545                 550                 555                 560 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                565                 570                 575     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            580                 585                 590         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        595                 600                 605             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    610                 615                 620                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
625                 630                 635                 640 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                645                 650                 655     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            660                 665                 670         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        675                 680                 685             
Leu Ser Leu Ser Pro Gly Lys 
    690                 695 

<210> 28
<211> 709
<212> PRT
<213> Artificial Sequence


<220> 
<223> SEQ36 fused to deglyco-Fc (incl. strep tag)

<400> 28
Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
305                 310                 315                 320 
Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
                325                 330                 335     
Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
            340                 345                 350         
Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
        355                 360                 365             
Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
    370                 375                 380                 
Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
385                 390                 395                 400 
Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
                405                 410                 415     
Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val 
            420                 425                 430         
Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
        435                 440                 445             
Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser Ser Ser Ser Ser 
    450                 455                 460                 
Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
465                 470                 475                 480 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                485                 490                 495     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            500                 505                 510         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        515                 520                 525             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    530                 535                 540                 
Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
545                 550                 555                 560 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                565                 570                 575     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            580                 585                 590         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        595                 600                 605             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    610                 615                 620                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
625                 630                 635                 640 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                645                 650                 655     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            660                 665                 670         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        675                 680                 685             
Leu Ser Leu Ser Pro Gly Ser Ser Ser Ser Ser Ser Ala Trp Ser His 
    690                 695                 700                 
Pro Gln Phe Glu Lys 
705                 

<210> 29
<211> 694
<212> PRT
<213> Artificial Sequence


<220> 
<223> SEQ36 fused to wt-Fc (no signal peptide, no strep tag)

<400> 29
Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
305                 310                 315                 320 
Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
                325                 330                 335     
Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
            340                 345                 350         
Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
        355                 360                 365             
Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
    370                 375                 380                 
Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
385                 390                 395                 400 
Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
                405                 410                 415     
Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val 
            420                 425                 430         
Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
        435                 440                 445             
Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser Ser Ser Ser Ser 
    450                 455                 460                 
Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
465                 470                 475                 480 
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                485                 490                 495     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            500                 505                 510         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        515                 520                 525             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    530                 535                 540                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
545                 550                 555                 560 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
                565                 570                 575     
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            580                 585                 590         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        595                 600                 605             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    610                 615                 620                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
625                 630                 635                 640 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                645                 650                 655     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            660                 665                 670         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        675                 680                 685             
Ser Leu Ser Pro Gly Lys 
    690                 

<210> 30
<211> 695
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq27 with altered first RBD module E1Q (equals E91Q in Seq1)

<400> 30
Gln Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
305                 310                 315                 320 
Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
                325                 330                 335     
Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
            340                 345                 350         
Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
        355                 360                 365             
Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
    370                 375                 380                 
Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
385                 390                 395                 400 
Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
                405                 410                 415     
Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val 
            420                 425                 430         
Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
        435                 440                 445             
Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser Ser Ser Ser Ser 
    450                 455                 460                 
Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
465                 470                 475                 480 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                485                 490                 495     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            500                 505                 510         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        515                 520                 525             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    530                 535                 540                 
Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
545                 550                 555                 560 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                565                 570                 575     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            580                 585                 590         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        595                 600                 605             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    610                 615                 620                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
625                 630                 635                 640 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                645                 650                 655     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            660                 665                 670         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        675                 680                 685             
Leu Ser Leu Ser Pro Gly Lys 
    690                 695 

<210> 31
<211> 701
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq39 fused to human IGG1 Fc of Seq13

<400> 31
Gln Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Asn Pro 
145                 150                 155                 160 
Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly 
                165                 170                 175     
Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu 
            180                 185                 190         
Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr 
        195                 200                 205             
Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu 
    210                 215                 220                 
Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro 
225                 230                 235                 240 
Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala 
                245                 250                 255     
Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val 
            260                 265                 270         
Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu 
        275                 280                 285             
Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe 
    290                 295                 300                 
Met Val Gly Ser Gly Ser Gly Asn Gly Ser Asn Pro Ala Ala His Leu 
305                 310                 315                 320 
Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp 
                325                 330                 335     
Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp 
            340                 345                 350         
Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys 
        355                 360                 365             
Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile 
    370                 375                 380                 
Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu 
385                 390                 395                 400 
Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser 
                405                 410                 415     
Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu 
            420                 425                 430         
Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg 
        435                 440                 445             
Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser 
    450                 455                 460                 
Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys 
465                 470                 475                 480 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                485                 490                 495     
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            500                 505                 510         
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        515                 520                 525             
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    530                 535                 540                 
Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 
545                 550                 555                 560 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                565                 570                 575     
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            580                 585                 590         
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        595                 600                 605             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    610                 615                 620                 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
625                 630                 635                 640 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                645                 650                 655     
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            660                 665                 670         
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        675                 680                 685             
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695                 700     

<210> 32
<211> 692
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq30 with shorter hinge linker

<400> 32
Gln Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
305                 310                 315                 320 
Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
                325                 330                 335     
Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
            340                 345                 350         
Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
        355                 360                 365             
Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
    370                 375                 380                 
Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
385                 390                 395                 400 
Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
                405                 410                 415     
Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val 
            420                 425                 430         
Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
        435                 440                 445             
Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser Ser Ser Gly Ser 
    450                 455                 460                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
465                 470                 475                 480 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                485                 490                 495     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            500                 505                 510         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        515                 520                 525             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr 
    530                 535                 540                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
545                 550                 555                 560 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                565                 570                 575     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            580                 585                 590         
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        595                 600                 605             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    610                 615                 620                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
625                 630                 635                 640 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                645                 650                 655     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            660                 665                 670         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        675                 680                 685             
Ser Pro Gly Lys 
    690         

<210> 33
<211> 699
<212> PRT
<213> Artificial Sequence


<220> 
<223> Configuration with deletion of N93 in RBD 2 and 3

<400> 33
Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala Ala His Leu Thr Gly 
305                 310                 315                 320 
Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
                325                 330                 335     
Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
            340                 345                 350         
Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
        355                 360                 365             
Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
    370                 375                 380                 
Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
385                 390                 395                 400 
Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
                405                 410                 415     
Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
            420                 425                 430         
Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
        435                 440                 445             
Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser 
    450                 455                 460                 
Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
465                 470                 475                 480 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                485                 490                 495     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            500                 505                 510         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        515                 520                 525             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    530                 535                 540                 
Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
545                 550                 555                 560 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                565                 570                 575     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            580                 585                 590         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        595                 600                 605             
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    610                 615                 620                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
625                 630                 635                 640 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                645                 650                 655     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            660                 665                 670         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        675                 680                 685             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695                 

<210> 34
<211> 699
<212> PRT
<213> Artificial Sequence


<220> 
<223> Configuration: SEQ33 with N terminal amino acid exchange E1Q

<400> 34
Gln Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala Ala His Leu Thr Gly 
305                 310                 315                 320 
Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
                325                 330                 335     
Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
            340                 345                 350         
Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
        355                 360                 365             
Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
    370                 375                 380                 
Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
385                 390                 395                 400 
Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
                405                 410                 415     
Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
            420                 425                 430         
Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
        435                 440                 445             
Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser 
    450                 455                 460                 
Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
465                 470                 475                 480 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                485                 490                 495     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            500                 505                 510         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        515                 520                 525             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    530                 535                 540                 
Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
545                 550                 555                 560 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                565                 570                 575     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            580                 585                 590         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        595                 600                 605             
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    610                 615                 620                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
625                 630                 635                 640 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                645                 650                 655     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            660                 665                 670         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        675                 680                 685             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695                 

<210> 35
<211> 696
<212> PRT
<213> Artificial Sequence


<220> 
<223> Configuration: Seq33 with shorter hinge linker

<400> 35
Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala Ala His Leu Thr Gly 
305                 310                 315                 320 
Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
                325                 330                 335     
Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
            340                 345                 350         
Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
        355                 360                 365             
Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
    370                 375                 380                 
Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
385                 390                 395                 400 
Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
                405                 410                 415     
Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
            420                 425                 430         
Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
        435                 440                 445             
Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Ser Ser 
    450                 455                 460                 
Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
465                 470                 475                 480 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                485                 490                 495     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            500                 505                 510         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        515                 520                 525             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    530                 535                 540                 
Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
545                 550                 555                 560 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                565                 570                 575     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            580                 585                 590         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        595                 600                 605             
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    610                 615                 620                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
625                 630                 635                 640 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                645                 650                 655     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            660                 665                 670         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        675                 680                 685             
Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695     

<210> 36
<211> 456
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exemplary scLIGHT-RBD module

<400> 36
Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
305                 310                 315                 320 
Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
                325                 330                 335     
Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
            340                 345                 350         
Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
        355                 360                 365             
Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
    370                 375                 380                 
Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
385                 390                 395                 400 
Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
                405                 410                 415     
Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val 
            420                 425                 430         
Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
        435                 440                 445             
Ser Tyr Phe Gly Ala Phe Met Val 
    450                 455     

<210> 37
<211> 2192
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA sequence encoding PROTEIN A (Seq25)

<400> 37
aagctttagg gataacaggg taatagccgc caccatggag actgacaccc tgctggtgtt      60

cgtgctgctg gtctgggtgc ctgcaggaaa tggagaagtg aaccccgccg cccatctgac     120

cggcgctaac agcagcctga caggttctgg cggacccctc ctgtgggaga cacaactggg     180

cctggccttc ctgaggggcc tgagctacca tgatggcgcc ctggtggtga ccaaggccgg     240

ctactactac atctattcca aggtccagct cggaggcgtg ggatgccctc tgggactggc     300

ctccaccatc acccacggcc tgtacaagcg gacccctagg taccccgagg aactggaact     360

gctcgtctcc caacagagcc cttgcggcag ggctacctcc tccagcaggg tgtggtggga     420

ctccagcttc ctgggaggcg tcgtccacct ggaggctgga gaagaagtgg tggtgcgggt     480

cctggacgaa aggctggtga ggctcaggga cggcacccgg tcctactttg gagcctttat     540

ggtgggctcc ggatctggta acggcagccc cgctgctcat ctgacaggcg ccaatagcag     600

cctgacaggc agcggaggcc ctctgctgtg ggaaacacag ctgggcctgg cctttctgag     660

gggcctgtcc tatcacgatg gagccctggt ggtgaccaaa gccggctatt actatatcta     720

cagcaaggtg cagctgggcg gagtgggatg tcctctgggc ctggcctcca ccatcacaca     780

cggactgtat aagcggacac ctaggtatcc cgaagagctg gagctcctgg tgtcccagca     840

aagcccttgt ggaagggcta cctccagcag cagggtctgg tgggactcct ccttcctggg     900

cggcgtggtc catctggaag ctggcgagga ggtggtggtg agggtcctgg atgagaggct     960

ggtcaggctg agggatggca cccggtccta ttttggcgct ttcatggtgg gctctggtag    1020

ccctgccgcc cacctgacag gagccaacag cagcctgaca ggaagcggcg gccctctgct    1080

gtgggagacc caactgggcc tggccttcct gcggggcctc tcctaccacg acggcgctct    1140

ggtggtgacc aaggccggct attattatat ctactccaaa gtccagctgg gaggcgtcgg    1200

ctgtcctctc ggactggctt ccaccatcac ccatggcctg tacaaaagga cccctaggta    1260

ccccgaagag ttagaactgc tggtctccca gcagtcccct tgcggaaggg ccacaagcag    1320

cagccgggtg tggtgggact ccagctttct gggcggagtg gtgcacctgg aagccggaga    1380

ggaggtcgtg gtcagggtcc tggatgaaag gctggtgcgg ctgagggatg gcaccaggtc    1440

ctatttcggc gccttcatgg tcggatcctc gagttcatcg tcctcatccg gctcatgtga    1500

taagacccac acctgccctc cctgtcctgc ccctgagctg ctgggcggac cttctgtgtt    1560

cctgttcccc cccaagccta aggacaccct gatgatctcc aggacccctg aggtgacctg    1620

tgtggtggtg gacgtgtctc acgaagatcc cgaggtgaag ttcaactggt acgtggacgg    1680

cgtggaggtc cacaacgcca agaccaagcc tagggaggag cagtacagct ccacctaccg    1740

ggtggtgtct gtgctgaccg tgctgcacca ggattggctg aacggaaagg agtataagtg    1800

taaggtctcc aacaaggccc tgcctgcccc catcgagaaa accatctcca aggccaaggg    1860

ccagcctcgg gagcctcagg tgtacaccct gcctcctagc agggaggaga tgaccaagaa    1920

ccaggtgtcc ctgacctgtc tggtgaaggg cttctaccct tccgatatcg ccgtggagtg    1980

ggagtctaat ggccagcccg agaacaacta caagaccacc cctcctgtgc tggactctga    2040

cggctccttc ttcctgtact ccaagctgac cgtggacaag tccagatggc agcagggcaa    2100

cgtgttctcc tgctccgtga tgcacgaggc cctgcacaat cactacaccc agaagtccct    2160

gtctctgagt ccgggcaagt aataggcgcg cc                                  2192


<210> 38
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> LIGHT-RBD fused to RB69 FOLDON (PROTEIN X)

<400> 38
Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 
1               5                   10                  15      
Ala Gly Asn Gly Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn 
            20                  25                  30          
Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu 
        35                  40                  45              
Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val 
    50                  55                  60                  
Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly 
65                  70                  75                  80  
Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu 
                85                  90                  95      
Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser 
            100                 105                 110         
Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp 
        115                 120                 125             
Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu 
    130                 135                 140                 
Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly 
145                 150                 155                 160 
Thr Arg Ser Tyr Phe Gly Ala Phe Met Val Gly Ser Gly Ser Ser Gly 
                165                 170                 175     
Ser Ser Gly Ser Ser Gly Ser Gly Tyr Ile Glu Asp Ala Pro Ser Asp 
            180                 185                 190         
Gly Lys Phe Tyr Val Arg Lys Asp Gly Ala Trp Val Glu Leu Pro Thr 
        195                 200                 205             
Ala Ser Gly Pro Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln 
    210                 215                 220                 
Phe Glu Lys 
225         

<210> 39
<211> 462
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exemplary scLIGHT-RBD module

<400> 39
Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Asn Pro 
145                 150                 155                 160 
Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly 
                165                 170                 175     
Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu 
            180                 185                 190         
Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr 
        195                 200                 205             
Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu 
    210                 215                 220                 
Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro 
225                 230                 235                 240 
Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala 
                245                 250                 255     
Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val 
            260                 265                 270         
Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu 
        275                 280                 285             
Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe 
    290                 295                 300                 
Met Val Gly Ser Gly Ser Gly Asn Gly Ser Asn Pro Ala Ala His Leu 
305                 310                 315                 320 
Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp 
                325                 330                 335     
Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp 
            340                 345                 350         
Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys 
        355                 360                 365             
Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile 
    370                 375                 380                 
Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu 
385                 390                 395                 400 
Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser 
                405                 410                 415     
Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu 
            420                 425                 430         
Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg 
        435                 440                 445             
Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
    450                 455                 460         

<210> 40
<211> 460
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exemplary scLIGHT-RBD module

<400> 40
Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
1               5                   10                  15      
Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
            20                  25                  30          
Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
        35                  40                  45              
Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
    50                  55                  60                  
Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
65                  70                  75                  80  
Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
                85                  90                  95      
Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
            100                 105                 110         
Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Glu Val Val Val Arg 
        115                 120                 125             
Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
    130                 135                 140                 
Phe Gly Ala Phe Met Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala 
145                 150                 155                 160 
Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
                165                 170                 175     
Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
            180                 185                 190         
Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
        195                 200                 205             
Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
    210                 215                 220                 
Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
225                 230                 235                 240 
Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
                245                 250                 255     
Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
            260                 265                 270         
His Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg 
        275                 280                 285             
Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
    290                 295                 300                 
Val Gly Ser Gly Ser Gly Asn Gly Ser Pro Ala Ala His Leu Thr Gly 
305                 310                 315                 320 
Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
                325                 330                 335     
Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
            340                 345                 350         
Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
        355                 360                 365             
Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
    370                 375                 380                 
Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
385                 390                 395                 400 
Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
                405                 410                 415     
Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
            420                 425                 430         
Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
        435                 440                 445             
Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
    450                 455                 460 

