                         SEQUENCE LISTING

<110>  Wayne State University
 
<120>  TREATMENTS AND DIAGNOSTICS FOR CANCERS

<130>  W063-0039PCT

<150>  62/241,574
<151>  2015-10-14

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr Ser 
65                  70                  75                  80  


Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro Gln Ala 
                85                  90                  95      


His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu Gln Gln 
            100                 105                 110         


Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu Arg Gly Cys 
        115                 120                 125             


Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly Leu Pro Gln 
    130                 135                 140                 


Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro Ser Thr 
145                 150                 155                 160 


Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser Ala 
                165                 170                 175     


Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu Leu Gln 
            180                 185                 190         


Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly Arg Ala 
        195                 200                 205             


Arg Glu Arg Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr Leu Gly 
    210                 215                 220                 


Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys Lys Ala Val 
225                 230                 235                 240 


Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser Pro 
                245                 250                 255     


Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly Val 
            260                 265                 270         


Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys Lys 
        275                 280                 285             


Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp Thr Ala 
    290                 295                 300                 


Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu Gly Glu 
305                 310                 315                 320 


Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly Thr Leu 
                325                 330                 335     


Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp Glu 
            340                 345                 350         


Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu Ala Leu 
        355                 360                 365             


Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala Arg Ile 
    370                 375                 380                 


Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala Gly Ala 
                405                 410                 415     


Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser Ser Trp 
            420                 425                 430         


His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Cys Gly 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro Tyr Gly Tyr 
465                 470                 475                 480 


Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp Phe Thr Ala 
                485                 490                 495     


Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val Pro Tyr Pro 
            500                 505                 510         


Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met Asp Ser Tyr 
        515                 520                 525             


Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg Asp His Val 
    530                 535                 540                 


Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys 
545                 550                 555                 560 


Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser 
                565                 570                 575     


Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu 
            580                 585                 590         


Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn 
        595                 600                 605             


Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu 
    610                 615                 620                 


Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu 
625                 630                 635                 640 


Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr Gln Lys 
                645                 650                 655     


Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu 
            660                 665                 670         


Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp 
        675                 680                 685             


Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu 
    690                 695                 700                 


Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu 
705                 710                 715                 720 


Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln 
                725                 730                 735     


Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe 
            740                 745                 750         


Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe 
        755                 760                 765             


Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg 
    770                 775                 780                 


Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln 
785                 790                 795                 800 


Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val 
                805                 810                 815     


Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr 
            820                 825                 830         


Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr 
        835                 840                 845             


Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val 
    850                 855                 860                 


Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile 
865                 870                 875                 880 


Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile 
                885                 890                 895     


Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile 
            900                 905                 910         


Tyr Phe His Thr Gln 
        915         


<210>  2
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln 
                85                  90                  95      


Gly Glu Asp Gly Ser Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr 
            100                 105                 110         


Leu Val Leu Asp Glu Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu 
        115                 120                 125             


Glu Cys His Pro Glu Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val 
    130                 135                 140                 


Ala Ala Ser Lys Gly Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu 
145                 150                 155                 160 


Asp Asp Ser Ala Ala Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe 
                165                 170                 175     


Pro Gly Leu Ser Ser Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu 
            180                 185                 190         


Ala Ser Thr Met Gln Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser 
        195                 200                 205             


Glu Gly Ser Ser Ser Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr 
    210                 215                 220                 


Ser Ser Lys Asp Asn Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn 
225                 230                 235                 240 


Ala Lys Glu Leu Cys Lys Ala Val Ser Val Ser Met Gly Leu Gly Val 
                245                 250                 255     


Glu Ala Leu Glu His Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys 
            260                 265                 270         


Met Tyr Ala Pro Leu Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro 
        275                 280                 285             


Cys Ala Pro Leu Ala Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala 
    290                 295                 300                 


Gly Lys Ser Thr Glu Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly 
305                 310                 315                 320 


Tyr Thr Lys Gly Leu Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala 
                325                 330                 335     


Ala Ala Gly Ser Ser Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu 
            340                 345                 350         


Tyr Lys Ser Gly Ala Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp 
        355                 360                 365             


Tyr Tyr Asn Phe Pro Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro 
    370                 375                 380                 


Pro Pro His Pro His Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr 
385                 390                 395                 400 


Gly Ser Ala Trp Ala Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu 
                405                 410                 415     


Ala Ser Leu His Gly Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro 
            420                 425                 430         


Ser Ala Ala Ala Ser Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu 
        435                 440                 445             


Gly Gln Leu Tyr Gly Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala 
465                 470                 475                 480 


Pro Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser 
                485                 490                 495     


Asp Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg 
            500                 505                 510         


Val Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp 
        515                 520                 525             


Met Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala 
    530                 535                 540                 


Arg Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr 
545                 550                 555                 560 


Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu 
                565                 570                 575     


Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys 
            580                 585                 590         


Gln Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe 
        595                 600                 605             


Arg Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala 
    610                 615                 620                 


Gly Met Thr Leu Gly Glu Lys Phe Arg Val Gly Asn Cys Lys His Leu 
625                 630                 635                 640 


Lys Met Thr Arg Pro 
                645 


<210>  3
<211>  2472
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Pro Ser Gly Val Lys Val Leu Glu Thr Ala Glu Asp Ile Gln 
1               5                   10                  15      


Glu Arg Arg Gln Gln Val Leu Asp Arg Tyr His Arg Phe Lys Glu Leu 
            20                  25                  30          


Ser Thr Leu Arg Arg Gln Lys Leu Glu Asp Ser Tyr Arg Phe Gln Phe 
        35                  40                  45              


Phe Gln Arg Asp Ala Glu Glu Leu Glu Lys Trp Ile Gln Glu Lys Leu 
    50                  55                  60                  


Gln Ile Ala Ser Asp Glu Asn Tyr Lys Asp Pro Thr Asn Leu Gln Gly 
65                  70                  75                  80  


Lys Leu Gln Lys His Gln Ala Phe Glu Ala Glu Val Gln Ala Asn Ser 
                85                  90                  95      


Gly Ala Ile Val Lys Leu Asp Glu Thr Gly Asn Leu Met Ile Ser Glu 
            100                 105                 110         


Gly His Phe Ala Ser Glu Thr Ile Arg Thr Arg Leu Met Glu Leu His 
        115                 120                 125             


Arg Gln Trp Glu Leu Leu Leu Glu Lys Met Arg Glu Lys Gly Ile Lys 
    130                 135                 140                 


Leu Leu Gln Ala Gln Lys Leu Val Gln Tyr Leu Arg Glu Cys Glu Asp 
145                 150                 155                 160 


Val Met Asp Trp Ile Asn Asp Lys Glu Ala Ile Val Thr Ser Glu Glu 
                165                 170                 175     


Leu Gly Gln Asp Leu Glu His Val Glu Val Leu Gln Lys Lys Phe Glu 
            180                 185                 190         


Glu Phe Gln Thr Asp Met Ala Ala His Glu Glu Arg Val Asn Glu Val 
        195                 200                 205             


Asn Gln Phe Ala Ala Lys Leu Ile Gln Glu Gln His Pro Glu Glu Glu 
    210                 215                 220                 


Leu Ile Lys Thr Lys Gln Asp Glu Val Asn Ala Ala Trp Gln Arg Leu 
225                 230                 235                 240 


Lys Gly Leu Ala Leu Gln Arg Gln Gly Lys Leu Phe Gly Ala Ala Glu 
                245                 250                 255     


Val Gln Arg Phe Asn Arg Asp Val Asp Glu Thr Ile Ser Trp Ile Lys 
            260                 265                 270         


Glu Lys Glu Gln Leu Met Ala Ser Asp Asp Phe Gly Arg Asp Leu Ala 
        275                 280                 285             


Ser Val Gln Ala Leu Leu Arg Lys His Glu Gly Leu Glu Arg Asp Leu 
    290                 295                 300                 


Ala Ala Leu Glu Asp Lys Val Lys Ala Leu Cys Ala Glu Ala Asp Arg 
305                 310                 315                 320 


Leu Gln Gln Ser His Pro Leu Ser Ala Thr Gln Ile Gln Val Lys Arg 
                325                 330                 335     


Glu Glu Leu Ile Thr Asn Trp Glu Gln Ile Arg Thr Leu Ala Ala Glu 
            340                 345                 350         


Arg His Ala Arg Leu Asn Asp Ser Tyr Arg Leu Gln Arg Phe Leu Ala 
        355                 360                 365             


Asp Phe Arg Asp Leu Thr Ser Trp Val Thr Glu Met Lys Ala Leu Ile 
    370                 375                 380                 


Asn Ala Asp Glu Leu Ala Ser Asp Val Ala Gly Ala Glu Ala Leu Leu 
385                 390                 395                 400 


Asp Arg His Gln Glu His Lys Gly Glu Ile Asp Ala His Glu Asp Ser 
                405                 410                 415     


Phe Lys Ser Ala Asp Glu Ser Gly Gln Ala Leu Leu Ala Ala Gly His 
            420                 425                 430         


Tyr Ala Ser Asp Glu Val Arg Glu Lys Leu Thr Val Leu Ser Glu Glu 
        435                 440                 445             


Arg Ala Ala Leu Leu Glu Leu Trp Glu Leu Arg Arg Gln Gln Tyr Glu 
    450                 455                 460                 


Gln Cys Met Asp Leu Gln Leu Phe Tyr Arg Asp Thr Glu Gln Val Asp 
465                 470                 475                 480 


Asn Trp Met Ser Lys Gln Glu Ala Phe Leu Leu Asn Glu Asp Leu Gly 
                485                 490                 495     


Asp Ser Leu Asp Ser Val Glu Ala Leu Leu Lys Lys His Glu Asp Phe 
            500                 505                 510         


Glu Lys Ser Leu Ser Ala Gln Glu Glu Lys Ile Thr Ala Leu Asp Glu 
        515                 520                 525             


Phe Ala Thr Lys Leu Ile Gln Asn Asn His Tyr Ala Met Glu Asp Val 
    530                 535                 540                 


Ala Thr Arg Arg Asp Ala Leu Leu Ser Arg Arg Asn Ala Leu His Glu 
545                 550                 555                 560 


Arg Ala Met Arg Arg Arg Ala Gln Leu Ala Asp Ser Phe His Leu Gln 
                565                 570                 575     


Gln Phe Phe Arg Asp Ser Asp Glu Leu Lys Ser Trp Val Asn Glu Lys 
            580                 585                 590         


Met Lys Thr Ala Thr Asp Glu Ala Tyr Lys Asp Pro Ser Asn Leu Gln 
        595                 600                 605             


Gly Lys Val Gln Lys His Gln Ala Phe Glu Ala Glu Leu Ser Ala Asn 
    610                 615                 620                 


Gln Ser Arg Ile Asp Ala Leu Glu Lys Ala Gly Gln Lys Leu Ile Asp 
625                 630                 635                 640 


Val Asn His Tyr Ala Lys Asp Glu Val Ala Ala Arg Met Asn Glu Val 
                645                 650                 655     


Ile Ser Leu Trp Lys Lys Leu Leu Glu Ala Thr Glu Leu Lys Gly Ile 
            660                 665                 670         


Lys Leu Arg Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu 
        675                 680                 685             


Asp Ile Glu Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp 
    690                 695                 700                 


Asp Tyr Gly Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His 
705                 710                 715                 720 


Ala Leu Leu Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly 
                725                 730                 735     


Ile Thr Ile Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala 
            740                 745                 750         


Glu Asn Ile Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala 
        755                 760                 765             


Leu Lys Glu Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu 
    770                 775                 780                 


Arg Leu Gln Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile 
785                 790                 795                 800 


Arg Glu Lys Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu 
                805                 810                 815     


Ile Gly Val Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu 
            820                 825                 830         


Ile Ala Gly His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn 
        835                 840                 845             


Ala Met Val Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys 
    850                 855                 860                 


Leu His Glu Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser 
865                 870                 875                 880 


Gln Arg Arg Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe 
                885                 890                 895     


Ala Asp Ala Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile 
            900                 905                 910         


Val Gly Ser Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu 
        915                 920                 925             


Leu Lys Lys His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser 
    930                 935                 940                 


Ser Ile Gln Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val 
945                 950                 955                 960 


Ala Pro Thr Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr 
                965                 970                 975     


Asp Tyr Gln Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp 
            980                 985                 990         


Ile Leu Thr Leu Leu Asn Ser Thr  Asn Lys Asp Trp Trp  Lys Val Glu 
        995                 1000                 1005             


Val Asn  Asp Arg Gln Gly Phe  Val Pro Ala Ala Tyr  Val Lys Lys 
    1010                 1015                 1020             


Leu Asp  Pro Ala Gln Ser Ala  Ser Arg Glu Asn Leu  Leu Glu Glu 
    1025                 1030                 1035             


Gln Gly  Ser Ile Ala Leu Arg  Gln Glu Gln Ile Asp  Asn Gln Thr 
    1040                 1045                 1050             


Arg Ile  Thr Lys Glu Ala Gly  Ser Val Ser Leu Arg  Met Lys Gln 
    1055                 1060                 1065             


Val Glu  Glu Leu Tyr His Ser  Leu Leu Glu Leu Gly  Glu Lys Arg 
    1070                 1075                 1080             


Lys Gly  Met Leu Glu Lys Ser  Cys Lys Lys Phe Met  Leu Phe Arg 
    1085                 1090                 1095             


Glu Ala  Asn Glu Leu Gln Gln  Trp Ile Asn Glu Lys  Glu Ala Ala 
    1100                 1105                 1110             


Leu Thr  Ser Glu Glu Val Gly  Ala Asp Leu Glu Gln  Val Glu Val 
    1115                 1120                 1125             


Leu Gln  Lys Lys Phe Asp Asp  Phe Gln Lys Asp Leu  Lys Ala Asn 
    1130                 1135                 1140             


Glu Ser  Arg Leu Lys Asp Ile  Asn Lys Val Ala Glu  Asp Leu Glu 
    1145                 1150                 1155             


Ser Glu  Gly Leu Met Ala Glu  Glu Val Gln Ala Val  Gln Gln Gln 
    1160                 1165                 1170             


Glu Val  Tyr Gly Met Met Pro  Arg Asp Glu Thr Asp  Ser Lys Thr 
    1175                 1180                 1185             


Ala Ser  Pro Trp Lys Ser Ala  Arg Leu Met Val His  Thr Val Ala 
    1190                 1195                 1200             


Thr Phe  Asn Ser Ile Lys Glu  Leu Asn Glu Arg Trp  Arg Ser Leu 
    1205                 1210                 1215             


Gln Gln  Leu Ala Glu Glu Arg  Ser Gln Leu Leu Gly  Ser Ala His 
    1220                 1225                 1230             


Glu Val  Gln Arg Phe His Arg  Asp Ala Asp Glu Thr  Lys Glu Trp 
    1235                 1240                 1245             


Ile Glu  Glu Lys Asn Gln Ala  Leu Asn Thr Asp Asn  Tyr Gly His 
    1250                 1255                 1260             


Asp Leu  Ala Ser Val Gln Ala  Leu Gln Arg Lys His  Glu Gly Phe 
    1265                 1270                 1275             


Glu Arg  Asp Leu Ala Ala Leu  Gly Asp Lys Val Asn  Ser Leu Gly 
    1280                 1285                 1290             


Glu Thr  Ala Glu Arg Leu Ile  Gln Ser His Pro Glu  Ser Ala Glu 
    1295                 1300                 1305             


Asp Leu  Gln Glu Lys Cys Thr  Glu Leu Asn Gln Ala  Trp Ser Ser 
    1310                 1315                 1320             


Leu Gly  Lys Arg Ala Asp Gln  Arg Lys Ala Lys Leu  Gly Asp Ser 
    1325                 1330                 1335             


His Asp  Leu Gln Arg Phe Leu  Ser Asp Phe Arg Asp  Leu Met Ser 
    1340                 1345                 1350             


Trp Ile  Asn Gly Ile Arg Gly  Leu Val Ser Ser Asp  Glu Leu Ala 
    1355                 1360                 1365             


Lys Asp  Val Thr Gly Ala Glu  Ala Leu Leu Glu Arg  His Gln Glu 
    1370                 1375                 1380             


His Arg  Thr Glu Ile Asp Ala  Arg Ala Gly Thr Phe  Gln Ala Phe 
    1385                 1390                 1395             


Glu Gln  Phe Gly Gln Gln Leu  Leu Ala His Gly His  Tyr Ala Ser 
    1400                 1405                 1410             


Pro Glu  Ile Lys Gln Lys Leu  Asp Ile Leu Asp Gln  Glu Arg Ala 
    1415                 1420                 1425             


Asp Leu  Glu Lys Ala Trp Val  Gln Arg Arg Met Met  Leu Asp Gln 
    1430                 1435                 1440             


Cys Leu  Glu Leu Gln Leu Phe  His Arg Asp Cys Glu  Gln Ala Glu 
    1445                 1450                 1455             


Asn Trp  Met Ala Ala Arg Glu  Ala Phe Leu Asn Thr  Glu Asp Lys 
    1460                 1465                 1470             


Gly Asp  Ser Leu Asp Ser Val  Glu Ala Leu Ile Lys  Lys His Glu 
    1475                 1480                 1485             


Asp Phe  Asp Lys Ala Ile Asn  Val Gln Glu Glu Lys  Ile Ala Ala 
    1490                 1495                 1500             


Leu Gln  Ala Phe Ala Asp Gln  Leu Ile Ala Ala Gly  His Tyr Ala 
    1505                 1510                 1515             


Lys Gly  Asp Ile Ser Ser Arg  Arg Asn Glu Val Leu  Asp Arg Trp 
    1520                 1525                 1530             


Arg Arg  Leu Lys Ala Gln Met  Ile Glu Lys Arg Ser  Lys Leu Gly 
    1535                 1540                 1545             


Glu Ser  Gln Thr Leu Gln Gln  Phe Ser Arg Asp Val  Asp Glu Ile 
    1550                 1555                 1560             


Glu Ala  Trp Ile Ser Glu Lys  Leu Gln Thr Ala Ser  Asp Glu Ser 
    1565                 1570                 1575             


Tyr Lys  Asp Pro Thr Asn Ile  Gln Ser Lys His Gln  Lys His Gln 
    1580                 1585                 1590             


Ala Phe  Glu Ala Glu Leu His  Ala Asn Ala Asp Arg  Ile Arg Gly 
    1595                 1600                 1605             


Val Ile  Asp Met Gly Asn Ser  Leu Ile Glu Arg Gly  Ala Cys Ala 
    1610                 1615                 1620             


Gly Ser  Glu Asp Ala Val Lys  Ala Arg Leu Ala Ala  Leu Ala Asp 
    1625                 1630                 1635             


Gln Trp  Gln Phe Leu Val Gln  Lys Ser Ala Glu Lys  Ser Gln Lys 
    1640                 1645                 1650             


Leu Lys  Glu Ala Asn Lys Gln  Gln Asn Phe Asn Thr  Gly Ile Lys 
    1655                 1660                 1665             


Asp Phe  Asp Phe Trp Leu Ser  Glu Val Glu Ala Leu  Leu Ala Ser 
    1670                 1675                 1680             


Glu Asp  Tyr Gly Lys Asp Leu  Ala Ser Val Asn Asn  Leu Leu Lys 
    1685                 1690                 1695             


Lys His  Gln Leu Leu Glu Ala  Asp Ile Ser Ala His  Glu Asp Arg 
    1700                 1705                 1710             


Leu Lys  Asp Leu Asn Ser Gln  Ala Asp Ser Leu Met  Thr Ser Ser 
    1715                 1720                 1725             


Ala Phe  Asp Thr Ser Gln Val  Lys Asp Lys Arg Asp  Thr Ile Asn 
    1730                 1735                 1740             


Gly Arg  Phe Gln Lys Ile Lys  Ser Met Ala Ala Ser  Arg Arg Ala 
    1745                 1750                 1755             


Lys Leu  Asn Glu Ser His Arg  Leu His Gln Phe Phe  Arg Asp Met 
    1760                 1765                 1770             


Asp Asp  Glu Glu Ser Trp Ile  Lys Glu Lys Lys Leu  Leu Val Gly 
    1775                 1780                 1785             


Ser Glu  Asp Tyr Gly Arg Asp  Leu Thr Gly Val Gln  Asn Leu Arg 
    1790                 1795                 1800             


Lys Lys  His Lys Arg Leu Glu  Ala Glu Leu Ala Ala  His Glu Pro 
    1805                 1810                 1815             


Ala Ile  Gln Gly Val Leu Asp  Thr Gly Lys Lys Leu  Ser Asp Asp 
    1820                 1825                 1830             


Asn Thr  Ile Gly Lys Glu Glu  Ile Gln Gln Arg Leu  Ala Gln Phe 
    1835                 1840                 1845             


Val Glu  His Trp Lys Glu Leu  Lys Gln Leu Ala Ala  Ala Arg Gly 
    1850                 1855                 1860             


Gln Arg  Leu Glu Glu Ser Leu  Glu Tyr Gln Gln Phe  Val Ala Asn 
    1865                 1870                 1875             


Val Glu  Glu Glu Glu Ala Trp  Ile Asn Glu Lys Met  Thr Leu Val 
    1880                 1885                 1890             


Ala Ser  Glu Asp Tyr Gly Asp  Thr Leu Ala Ala Ile  Gln Gly Leu 
    1895                 1900                 1905             


Leu Lys  Lys His Glu Ala Phe  Glu Thr Asp Phe Thr  Val His Lys 
    1910                 1915                 1920             


Asp Arg  Val Asn Asp Val Cys  Thr Asn Gly Gln Asp  Leu Ile Lys 
    1925                 1930                 1935             


Lys Asn  Asn His His Glu Glu  Asn Ile Ser Ser Lys  Met Lys Gly 
    1940                 1945                 1950             


Leu Asn  Gly Lys Val Ser Asp  Leu Glu Lys Ala Ala  Ala Gln Arg 
    1955                 1960                 1965             


Lys Ala  Lys Leu Asp Glu Asn  Ser Ala Phe Leu Gln  Phe Asn Trp 
    1970                 1975                 1980             


Lys Ala  Asp Val Val Glu Ser  Trp Ile Gly Glu Lys  Glu Asn Ser 
    1985                 1990                 1995             


Leu Lys  Thr Asp Asp Tyr Gly  Arg Asp Leu Ser Ser  Val Gln Thr 
    2000                 2005                 2010             


Leu Leu  Thr Lys Gln Glu Thr  Phe Asp Ala Gly Leu  Gln Ala Phe 
    2015                 2020                 2025             


Gln Gln  Glu Gly Ile Ala Asn  Ile Thr Ala Leu Lys  Asp Gln Leu 
    2030                 2035                 2040             


Leu Ala  Ala Lys His Val Gln  Ser Lys Ala Ile Glu  Ala Arg His 
    2045                 2050                 2055             


Ala Ser  Leu Met Lys Arg Trp  Ser Gln Leu Leu Ala  Asn Ser Ala 
    2060                 2065                 2070             


Ala Arg  Lys Lys Lys Leu Leu  Glu Ala Gln Ser His  Phe Arg Lys 
    2075                 2080                 2085             


Val Glu  Asp Leu Phe Leu Thr  Phe Ala Lys Lys Ala  Ser Ala Phe 
    2090                 2095                 2100             


Asn Ser  Trp Phe Glu Asn Ala  Glu Glu Asp Leu Thr  Asp Pro Val 
    2105                 2110                 2115             


Arg Cys  Asn Ser Leu Glu Glu  Ile Lys Ala Leu Arg  Glu Ala His 
    2120                 2125                 2130             


Asp Ala  Phe Arg Ser Ser Leu  Ser Ser Ala Gln Ala  Asp Phe Asn 
    2135                 2140                 2145             


Gln Leu  Ala Glu Leu Asp Arg  Gln Ile Lys Ser Phe  Arg Val Ala 
    2150                 2155                 2160             


Ser Asn  Pro Tyr Thr Trp Phe  Thr Met Glu Ala Leu  Glu Glu Thr 
    2165                 2170                 2175             


Trp Arg  Asn Leu Gln Lys Ile  Ile Lys Glu Arg Glu  Leu Glu Leu 
    2180                 2185                 2190             


Gln Lys  Glu Gln Arg Arg Gln  Glu Glu Asn Asp Lys  Leu Arg Gln 
    2195                 2200                 2205             


Glu Phe  Ala Gln His Ala Asn  Ala Phe His Gln Trp  Ile Gln Glu 
    2210                 2215                 2220             


Thr Arg  Thr Tyr Leu Leu Asp  Gly Ser Cys Met Val  Glu Glu Ser 
    2225                 2230                 2235             


Gly Thr  Leu Glu Ser Gln Leu  Glu Ala Thr Lys Arg  Lys His Gln 
    2240                 2245                 2250             


Glu Ile  Arg Ala Met Arg Ser  Gln Leu Lys Lys Ile  Glu Asp Leu 
    2255                 2260                 2265             


Gly Ala  Ala Met Glu Glu Ala  Leu Ile Leu Asp Asn  Lys Tyr Thr 
    2270                 2275                 2280             


Glu His  Ser Thr Val Gly Leu  Ala Gln Gln Trp Asp  Gln Leu Asp 
    2285                 2290                 2295             


Gln Leu  Gly Met Arg Met Gln  His Asn Leu Glu Gln  Gln Ile Gln 
    2300                 2305                 2310             


Ala Arg  Asn Thr Thr Gly Val  Thr Glu Glu Ala Leu  Lys Glu Phe 
    2315                 2320                 2325             


Ser Met  Met Phe Lys His Phe  Asp Lys Asp Lys Ser  Gly Arg Leu 
    2330                 2335                 2340             


Asn His  Gln Glu Phe Lys Ser  Cys Leu Arg Ser Leu  Gly Tyr Asp 
    2345                 2350                 2355             


Leu Pro  Met Val Glu Glu Gly  Glu Pro Asp Pro Glu  Phe Glu Ala 
    2360                 2365                 2370             


Ile Leu  Asp Thr Val Asp Pro  Asn Arg Asp Gly His  Val Ser Leu 
    2375                 2380                 2385             


Gln Glu  Tyr Met Ala Phe Met  Ile Ser Arg Glu Thr  Glu Asn Val 
    2390                 2395                 2400             


Lys Ser  Ser Glu Glu Ile Glu  Ser Ala Phe Arg Ala  Leu Ser Ser 
    2405                 2410                 2415             


Glu Gly  Lys Pro Tyr Val Thr  Lys Glu Glu Leu Tyr  Gln Asn Leu 
    2420                 2425                 2430             


Thr Arg  Glu Gln Ala Asp Tyr  Cys Val Ser His Met  Lys Pro Tyr 
    2435                 2440                 2445             


Val Asp  Gly Lys Gly Arg Glu  Leu Pro Thr Ala Phe  Asp Tyr Val 
    2450                 2455                 2460             


Glu Phe  Thr Arg Ser Leu Phe  Val Asn 
    2465                 2470         


<210>  4
<211>  1014
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser 
1               5                   10                  15      


Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser 
            20                  25                  30          


Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val 
        35                  40                  45              


Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile 
    50                  55                  60                  


Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp 
65                  70                  75                  80  


Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly 
                85                  90                  95      


Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp 
            100                 105                 110         


Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys 
        115                 120                 125             


Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val 
    130                 135                 140                 


Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro 
145                 150                 155                 160 


Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr 
                165                 170                 175     


Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys 
            180                 185                 190         


Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg 
        195                 200                 205             


Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser 
    210                 215                 220                 


Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala 
225                 230                 235                 240 


Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys 
                245                 250                 255     


Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val 
            260                 265                 270         


Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val 
        275                 280                 285             


Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe 
    290                 295                 300                 


Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys 
305                 310                 315                 320 


Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro 
                325                 330                 335     


Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys 
            340                 345                 350         


Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr 
        355                 360                 365             


Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala 
    370                 375                 380                 


Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys 
385                 390                 395                 400 


Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly 
                405                 410                 415     


Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr 
            420                 425                 430         


Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu 
        435                 440                 445             


Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala 
    450                 455                 460                 


Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro 
465                 470                 475                 480 


Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg 
                485                 490                 495     


Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys 
            500                 505                 510         


Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys 
        515                 520                 525             


Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His 
    530                 535                 540                 


Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val 
545                 550                 555                 560 


Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu 
                565                 570                 575     


Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val 
            580                 585                 590         


Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu 
        595                 600                 605             


Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn 
    610                 615                 620                 


Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro 
625                 630                 635                 640 


Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr 
                645                 650                 655     


Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu 
            660                 665                 670         


Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu 
        675                 680                 685             


Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg 
    690                 695                 700                 


Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val 
705                 710                 715                 720 


Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe 
                725                 730                 735     


Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu 
            740                 745                 750         


Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu 
        755                 760                 765             


Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp 
    770                 775                 780                 


Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp 
785                 790                 795                 800 


Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys 
                805                 810                 815     


Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu 
            820                 825                 830         


Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr 
        835                 840                 845             


Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser 
    850                 855                 860                 


Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala 
865                 870                 875                 880 


Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr 
                885                 890                 895     


Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln 
            900                 905                 910         


Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn 
        915                 920                 925             


Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly 
    930                 935                 940                 


Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala 
945                 950                 955                 960 


Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser 
                965                 970                 975     


Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr 
            980                 985                 990         


Asp Ile Ala Gln Val Asn Leu Lys  Tyr Leu Leu Lys Leu  Lys Phe Asn 
        995                 1000                 1005             


Phe Lys  Thr Ser Leu Trp 
    1010                 


