                               SEQUENCE LISTING

<110> AQUINNAH PHARMACEUTICALS, INC.
      TRUSTEES OF BOSTON UNIVERSITY
 
<120> NUCLEIC ACID BASED TIA-1 INHIBITORS

<130> A2137-7013WO

<140>
<141>

<150> 62/331,795
<151> 2016-05-04

<150> 62/241,535
<151> 2015-10-14

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 4620
<212> DNA
<213> Homo sapiens

<400> 1
gctcctaggc tcccggctcg ccgccatctt gtattggggt ttcattgttc ccgctgggcc       60

gggcggttta gtgtaattgc cgccggagga ggaggcggag taacctctgg tcagccgaga      120

aaccccacta tcctgtagcc ataaccgctt aaacgatttg ggaggtagtg aagggcaggg      180

agctggacct ggaggcgccg ccgcgacagc agcagccatg gaggacgaga tgcccaagac      240

tctatacgtc ggtaaccttt ccagagatgt gacagaagct ctaattctgc aactctttag      300

ccagattgga ccttgtaaaa actgcaaaat gattatggat acagctggaa atgatcccta      360

ttgttttgtg gagtttcatg agcatcgtca tgcagctgca gcattagctg ctatgaatgg      420

acggaagata atgggtaagg aagtcaaagt gaattgggca acaaccccta gcagtcaaaa      480

gaaagataca agcaatcatt tccatgtctt tgttggtgat ctcagcccag aaattacaac      540

tgaagatata aaagctgctt ttgcaccatt tggaagaata tcagatgccc gagtggtaaa      600

agacatggca acaggaaagt ctaagggata tggctttgtc tcctttttca acaaatggga      660

tgctgaaaac gccattcaac agatgggtgg ccagtggctt ggtggaagac aaatcagaac      720

taactgggca acccgaaagc ctcccgctcc aaagagtaca tatgagtcaa ataccaaaca      780

gctatcatat gatgaggttg taaatcagtc tagtccaagc aactgtactg tatactgtgg      840

aggtgttact tctgggctaa cagaacaact aatgcgtcag actttttcac catttggaca      900

aataatggaa attcgagtct ttccagataa aggatattca tttgttcggt tcaattccca      960

tgaaagtgca gcacatgcaa ttgtttctgt taatggtact accattgaag gtcatgttgt     1020

gaaatgctat tggggcaaag aaactcttga tatgataaat cccgtgcaac agcagaatca     1080

aattggatat ccccaacctt atggccagtg gggccagtgg tatggaaatg cacaacaaat     1140

tggccagtat atgcctaatg gttggcaagt tcctgcatat ggaatgtatg gccaggcatg     1200

gaaccagcaa ggatttaatc agacacagtc ttctgcacca tggatgggac caaattatgg     1260

agtgcaaccg cctcaagggc aaaatggcag catgttgccc aatcagcctt ctgggtatcg     1320

agtggcaggg tatgaaaccc agtgaataag gactccagaa tctaaagcca gtggcttgag     1380

gctacaggga gtgtagtaaa gccgttgttt acttaaagat ttatcaaatc agtcagtgca     1440

aatgtcagat acaatgtatt tatttaaaag attcattttt aatcatgaaa ttacttatca     1500

tccacattgt tttaaaaaga aacaagatgc tggatgtctg ccaatttttg ccttcattac     1560

cttttttgat aaagtttctc agatccttgt ttcaaacaca aatgcaggga ttgctgccac     1620

tttttaacta ttaagaggca gaaaattgca caatattgaa cttttttcca ctgaagtagt     1680

gtgcagttct agtttgcatt cctgatatga tttaaaacat gtaatataaa gatgttaaaa     1740

aaaaaaacca aaactgtgca gagtctagaa gttgtttgtc atcttcagct tgtgcacaat     1800

tctgttttag gttaaaaaaa ggcattgttt gagctgtccc atctccactg ttatcccttt     1860

ggggtttttt aatataaatt attagtttac atcatttttg tatctacatc ttttttcaca     1920

aatttgtctt gccttattaa agttctgtaa aatatactta aatggaaaaa atgatgttca     1980

tttagattga aaacttttct cagatggatt gataattgca ttcatcttgt gttttatatg     2040

agaaggtgcc tcaagaattt cctgttggat ttgtttaaaa ggatttttat ctttcgtgat     2100

aaactttgct gtgtaccagg aactataaaa acaaaaactt gttactaaag aaaatatctg     2160

aaatgtgata agttcttatg ccatgttaat ttcatgtgtc aacttcaaca tttacatgta     2220

ttatttcatt atgtaaaatg ttttagcaat ttaatatttt gcacagttag caaactttgt     2280

atgtcatttc cttcaaggca tcatgcagag ttgacatgag atttataagg ttttaagttg     2340

tttgcatgtg aaaatcaaat acatactttg gtagtctttg aatacaaagt catctgctct     2400

tgtttttcaa gaattttgag acacaaagtt gtatgtaaag gaatatatta atttgccgtt     2460

ttctaggtag atttgctcaa aaagagtgaa tcaacttaat atgtacaaat gatagctgtg     2520

aaactgtaga atatctttgt gtcaggcttg gagttcattg tgacctccaa attttgcctg     2580

aaggaccagc tgggcaaagc atcttttaaa tgttcagagg ccaaaagata aacaaaaaaa     2640

aaaccttaaa atcctacctc tttaaacagc cttcagataa gagaatcctc agtgcaatca     2700

ttattttgat tcgtttggta cctgttttcc tggagttccc gattttatta ttttggggtg     2760

gctccaagca ttaagaggtt taatctttga tggcattgtt ctagttttga aatttctagt     2820

atatttcaga gtctcttaga agacttgtgt gggaagtttc actttgtttt cagtgaagat     2880

cacaaacctc cttcttcctt tactcaagag gaaaggtccc agtatacata tttgaatggt     2940

tgatggtttt caagaccttc agggagctcc ctgcatttta cctagaaaca gaaaaggccc     3000

gcaaaatctt aagtttcctg gcctgcattt cccgggtagg ggcaaatgac tccaagctgg     3060

tctctaagcc aataccctta taaaccagag cccaggaaag acagctcgag tgtataattc     3120

tctggagctc aattctatgc agttgtgctg atatttcatt aagtcactgt gtatttttaa     3180

gtgttgatac attaaaagtc gctttatgga agatgagtaa attttttaaa tacttggaaa     3240

ttttatttcc ttgttaactt ctacagatca gggcatgcaa ccaaaagcag cttaaatgaa     3300

atattttaaa ataaaatatc aggaagctat ttttagattt cttctggctt atgtttctac     3360

tttaggaccc tcattgttct cttattaaaa aaaattattt cctgtgcatc tcatggactg     3420

cagggtaaat tatttgggca taaataattt aaatagtttt ctttcatttt gactatctcc     3480

agtaataaca gtttttatta tccagcatat tggcttattg cacaaatctt aaaatgtaca     3540

ttgactactt tctgagaaga aagtggtatc agtactcatg atgaaaaggt tactactgaa     3600

caaattcaca tttcaggaac acctctatct ttggtttaaa tcttactctt agtttttccg     3660

tctaaaaatc atactggtat tagtatcagg taaggaaatt aaagttttta aaatggtttc     3720

attctctgca atatgcaaaa tttagatttt actttctggt actgtaaaga acctgaagtg     3780

atttacactt aatgggtgat taatccagta ttctttaccc tgaatgtttg gatattaaag     3840

ttcctttatg ttttctataa cctgtgggat cttcttgcag tgattattgt gtgtgagatt     3900

ttttttcttt ttggtctatc catattgtta tattcactca ggtatttttt ttttaatctt     3960

attccagaat cagtggttta tattgggtta ctgtttaaca ccaaatggaa ttggcattct     4020

gcagatttaa ttaattatga aaccagggtc tcattttcct tgctgatact tgttgaaaat     4080

gagattcaca ttctagtctt tattttcctc ctgttttgtc cctgtgcttg tacatcttcc     4140

ttttatttgt gtgttatagt tctattccat ttgagaaggc agttggtaag aactagattg     4200

catgtacaaa gacaggttta ctaagtgctg tacagtggtc ctgaggttac agttgaatta     4260

gaaaaacgaa atgtacttac aggaaataag aaagcaaacc tttcaaatga gagtgatgat     4320

ttctttaaaa aaaatcagtt tttttctctc aaataatgtt ctttatttca cgaaatcgtc     4380

aatcttaagc atgagcaggg ataaacaact cctagaagga actcaattca ttcttcctgg     4440

attttctctg ttgttaaatc acaaaaatga tagtccccaa tcgtttcttt ataggaggtt     4500

attacatttc attacagtca ctgcattttg actgttgtgt ttagaatttg aatgtacatc     4560

caaaatgatg agtttcaatt taagagcctt aataaaatgt gtgagtgtgt ctcaattgaa     4620


<210> 2
<211> 20
<212> DNA
<213> Homo sapiens

<400> 2
attggcagac atccagcatc                                                   20


<210> 3
<211> 20
<212> DNA
<213> Homo sapiens

<400> 3
gatgctggat gtctgccaat                                                   20


<210> 4
<211> 58
<212> DNA
<213> Homo sapiens

<400> 4
ccggcgatgc tggatgtctg ccaatctcga gattggcaga catccagcat cgtttttg         58


<210> 5
<211> 386
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Asp Glu Met Pro Lys Thr Leu Tyr Val Gly Asn Leu Ser Arg 
1               5                   10                  15      


Asp Val Thr Glu Ala Leu Ile Leu Gln Leu Phe Ser Gln Ile Gly Pro 
            20                  25                  30          


Cys Lys Asn Cys Lys Met Ile Met Asp Thr Ala Gly Asn Asp Pro Tyr 
        35                  40                  45              


Cys Phe Val Glu Phe His Glu His Arg His Ala Ala Ala Ala Leu Ala 
    50                  55                  60                  


Ala Met Asn Gly Arg Lys Ile Met Gly Lys Glu Val Lys Val Asn Trp 
65                  70                  75                  80  


Ala Thr Thr Pro Ser Ser Gln Lys Lys Asp Thr Ser Ser Ser Thr Val 
                85                  90                  95      


Val Ser Thr Gln Arg Ser Gln Asp His Phe His Val Phe Val Gly Asp 
            100                 105                 110         


Leu Ser Pro Glu Ile Thr Thr Glu Asp Ile Lys Ala Ala Phe Ala Pro 
        115                 120                 125             


Phe Gly Arg Ile Ser Asp Ala Arg Val Val Lys Asp Met Ala Thr Gly 
    130                 135                 140                 


Lys Ser Lys Gly Tyr Gly Phe Val Ser Phe Phe Asn Lys Trp Asp Ala 
145                 150                 155                 160 


Glu Asn Ala Ile Gln Gln Met Gly Gly Gln Trp Leu Gly Gly Arg Gln 
                165                 170                 175     


Ile Arg Thr Asn Trp Ala Thr Arg Lys Pro Pro Ala Pro Lys Ser Thr 
            180                 185                 190         


Tyr Glu Ser Asn Thr Lys Gln Leu Ser Tyr Asp Glu Val Val Asn Gln 
        195                 200                 205             


Ser Ser Pro Ser Asn Cys Thr Val Tyr Cys Gly Gly Val Thr Ser Gly 
    210                 215                 220                 


Leu Thr Glu Gln Leu Met Arg Gln Thr Phe Ser Pro Phe Gly Gln Ile 
225                 230                 235                 240 


Met Glu Ile Arg Val Phe Pro Asp Lys Gly Tyr Ser Phe Val Arg Phe 
                245                 250                 255     


Asn Ser His Glu Ser Ala Ala His Ala Ile Val Ser Val Asn Gly Thr 
            260                 265                 270         


Thr Ile Glu Gly His Val Val Lys Cys Tyr Trp Gly Lys Glu Thr Leu 
        275                 280                 285             


Asp Met Ile Asn Pro Val Gln Gln Gln Asn Gln Ile Gly Tyr Pro Gln 
    290                 295                 300                 


Pro Tyr Gly Gln Trp Gly Gln Trp Tyr Gly Asn Ala Gln Gln Ile Gly 
305                 310                 315                 320 


Gln Tyr Met Pro Asn Gly Trp Gln Val Pro Ala Tyr Gly Met Tyr Gly 
                325                 330                 335     


Gln Ala Trp Asn Gln Gln Gly Phe Asn Gln Thr Gln Ser Ser Ala Pro 
            340                 345                 350         


Trp Met Gly Pro Asn Tyr Gly Val Gln Pro Pro Gln Gly Gln Asn Gly 
        355                 360                 365             


Ser Met Leu Pro Asn Gln Pro Ser Gly Tyr Arg Val Ala Gly Tyr Glu 
    370                 375                 380                 


Thr Gln 
385     


<210> 6
<211> 375
<212> PRT
<213> Homo sapiens

<400> 6
Met Glu Asp Glu Met Pro Lys Thr Leu Tyr Val Gly Asn Leu Ser Arg 
1               5                   10                  15      


Asp Val Thr Glu Ala Leu Ile Leu Gln Leu Phe Ser Gln Ile Gly Pro 
            20                  25                  30          


Cys Lys Asn Cys Lys Met Ile Met Asp Thr Ala Gly Asn Asp Pro Tyr 
        35                  40                  45              


Cys Phe Val Glu Phe His Glu His Arg His Ala Ala Ala Ala Leu Ala 
    50                  55                  60                  


Ala Met Asn Gly Arg Lys Ile Met Gly Lys Glu Val Lys Val Asn Trp 
65                  70                  75                  80  


Ala Thr Thr Pro Ser Ser Gln Lys Lys Asp Thr Ser Asn His Phe His 
                85                  90                  95      


Val Phe Val Gly Asp Leu Ser Pro Glu Ile Thr Thr Glu Asp Ile Lys 
            100                 105                 110         


Ala Ala Phe Ala Pro Phe Gly Arg Ile Ser Asp Ala Arg Val Val Lys 
        115                 120                 125             


Asp Met Ala Thr Gly Lys Ser Lys Gly Tyr Gly Phe Val Ser Phe Phe 
    130                 135                 140                 


Asn Lys Trp Asp Ala Glu Asn Ala Ile Gln Gln Met Gly Gly Gln Trp 
145                 150                 155                 160 


Leu Gly Gly Arg Gln Ile Arg Thr Asn Trp Ala Thr Arg Lys Pro Pro 
                165                 170                 175     


Ala Pro Lys Ser Thr Tyr Glu Ser Asn Thr Lys Gln Leu Ser Tyr Asp 
            180                 185                 190         


Glu Val Val Asn Gln Ser Ser Pro Ser Asn Cys Thr Val Tyr Cys Gly 
        195                 200                 205             


Gly Val Thr Ser Gly Leu Thr Glu Gln Leu Met Arg Gln Thr Phe Ser 
    210                 215                 220                 


Pro Phe Gly Gln Ile Met Glu Ile Arg Val Phe Pro Asp Lys Gly Tyr 
225                 230                 235                 240 


Ser Phe Val Arg Phe Asn Ser His Glu Ser Ala Ala His Ala Ile Val 
                245                 250                 255     


Ser Val Asn Gly Thr Thr Ile Glu Gly His Val Val Lys Cys Tyr Trp 
            260                 265                 270         


Gly Lys Glu Thr Leu Asp Met Ile Asn Pro Val Gln Gln Gln Asn Gln 
        275                 280                 285             


Ile Gly Tyr Pro Gln Pro Tyr Gly Gln Trp Gly Gln Trp Tyr Gly Asn 
    290                 295                 300                 


Ala Gln Gln Ile Gly Gln Tyr Met Pro Asn Gly Trp Gln Val Pro Ala 
305                 310                 315                 320 


Tyr Gly Met Tyr Gly Gln Ala Trp Asn Gln Gln Gly Phe Asn Gln Thr 
                325                 330                 335     


Gln Ser Ser Ala Pro Trp Met Gly Pro Asn Tyr Gly Val Gln Pro Pro 
            340                 345                 350         


Gln Gly Gln Asn Gly Ser Met Leu Pro Asn Gln Pro Ser Gly Tyr Arg 
        355                 360                 365             


Val Ala Gly Tyr Glu Thr Gln 
    370                 375 


<210> 7
<211> 214
<212> PRT
<213> Homo sapiens

<400> 7
Met Glu Asp Glu Met Pro Lys Thr Leu Tyr Val Gly Asn Leu Ser Arg 
1               5                   10                  15      


Asp Val Thr Glu Ala Leu Ile Leu Gln Leu Phe Ser Gln Ile Gly Pro 
            20                  25                  30          


Cys Lys Asn Cys Lys Met Ile Met Asp Thr Ala Gly Asn Asp Pro Tyr 
        35                  40                  45              


Cys Phe Val Glu Phe His Glu His Arg His Ala Ala Ala Ala Leu Ala 
    50                  55                  60                  


Ala Met Asn Gly Arg Lys Ile Met Gly Lys Glu Val Lys Val Asn Trp 
65                  70                  75                  80  


Ala Thr Thr Pro Ser Ser Gln Lys Lys Asp Thr Ser Ser Ser Thr Val 
                85                  90                  95      


Val Ser Thr Gln Arg Ser Gln Asp His Phe His Val Phe Val Gly Asp 
            100                 105                 110         


Leu Ser Pro Glu Ile Thr Thr Glu Asp Ile Lys Ala Ala Phe Ala Pro 
        115                 120                 125             


Phe Gly Arg Ile Ser Asp Ala Arg Val Val Lys Asp Met Ala Thr Gly 
    130                 135                 140                 


Lys Ser Lys Gly Tyr Gly Phe Val Ser Phe Phe Asn Lys Trp Asp Ala 
145                 150                 155                 160 


Glu Asn Ala Ile Gln Gln Met Gly Gly Gln Trp Leu Gly Gly Arg Gln 
                165                 170                 175     


Ile Arg Thr Asn Trp Ala Thr Arg Lys Pro Pro Ala Pro Lys Ser Thr 
            180                 185                 190         


Tyr Glu Cys Arg Cys Ile Gly Glu Glu Lys Glu Met Trp Asn Phe Gly 
        195                 200                 205             


Glu Lys Tyr Ala Arg Phe 
    210                 


<210> 8
<211> 58
<212> DNA
<213> Homo sapiens

<400> 8
ccggcgatgg tggatgtttg ccaatctcga gattggcaaa catccaccat cgtttttg         58


<210> 9
<211> 20
<212> DNA
<213> Homo sapiens

<400> 9
attggcaaac atccaccatc                                                   20


<210> 10
<211> 20
<212> DNA
<213> Homo sapiens

<400> 10
gatggtggat gtttgccaat                                                   20


