                         SEQUENCE LISTING

<110>  Research Foundation of State University of New York
 
<120>  075098.00023

<130>  075098.00023

<150>  62/240,863
<151>  2015-10-13

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  834
<212>  DNA
<213>  artificial sequence

<220>
<223>  Coding for recombinant protein

<400>  1
atgaaagagg gcaaaacgat tggcctggtg atctctaccc tgaacaatcc gttctttgtg       60

accctgaaaa atggtgcgga agaaaaagcg aaagaactgg gttacaaaat tatcgttgaa      120

gattcgcaaa atgattcctc taaagagctg tctaatgtcg aagatttgat tcaacagaaa      180

gttgatgttc tgctgatcaa tccggtggat agcgatgcgg ttgttacggc gattaaagaa      240

gcgaatagca aaaatatccc ggttattacc atcgatcgca gcgcgaatgg tggtgatgtt      300

gtttcccata tcgccagcga taatgttaag ggtggcgaaa tggccgcgga atttatcgcg      360

aaagccctga aaggcaaggg gaatgttgtg gaactggaag ggatcccggg ggcgtctgcg      420

gcacgtgatc gcggcaaagg gtttgatgaa gccattgcta agtatccgga tattaaaatc      480

gttgcaaagc aggcggcgga ttttgatcgt tccaaaggtc tgtcagtgat ggaaaacatc      540

ttgcaagccc agccgaaaat tgatgcagtg tttgcgcaaa atgatgaaat ggctctgggc      600

gctatcaaag ccattgaggc cgcgaatcgt caaggtatta ttgttgtggg ctttgatggg      660

accgaagatg ctctgaaagc gattaaagaa gggaaaatgg ctgcgaccat tgcgcagcag      720

ccggccctga tgggctcact gggtgtggag atggctgata aatacctgaa aggtgaaaaa      780

attccgaact ttattccggc agaactgaaa ctcatcacga aagaaaatgt gcag            834


<210>  2
<211>  278
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified tteRBP protein

<400>  2

Met Lys Glu Gly Lys Thr Ile Gly Leu Val Ile Ser Thr Leu Asn Asn 
1               5                   10                  15      


Pro Phe Phe Val Thr Leu Lys Asn Gly Ala Glu Glu Lys Ala Lys Glu 
            20                  25                  30          


Leu Gly Tyr Lys Ile Ile Val Glu Asp Ser Gln Asn Asp Ser Ser Lys 
        35                  40                  45              


Glu Leu Ser Asn Val Glu Asp Leu Ile Gln Gln Lys Val Asp Val Leu 
    50                  55                  60                  


Leu Ile Asn Pro Val Asp Ser Asp Ala Val Val Thr Ala Ile Lys Glu 
65                  70                  75                  80  


Ala Asn Ser Lys Asn Ile Pro Val Ile Thr Ile Asp Arg Ser Ala Asn 
                85                  90                  95      


Gly Gly Asp Val Val Ser His Ile Ala Ser Asp Asn Val Lys Gly Gly 
            100                 105                 110         


Glu Met Ala Ala Glu Phe Ile Ala Lys Ala Leu Lys Gly Lys Gly Asn 
        115                 120                 125             


Val Val Glu Leu Glu Gly Ile Pro Gly Ala Ser Ala Ala Arg Asp Arg 
    130                 135                 140                 


Gly Lys Gly Phe Asp Glu Ala Ile Ala Lys Tyr Pro Asp Ile Lys Ile 
145                 150                 155                 160 


Val Ala Lys Gln Ala Ala Asp Phe Asp Arg Ser Lys Gly Leu Ser Val 
                165                 170                 175     


Met Glu Asn Ile Leu Gln Ala Gln Pro Lys Ile Asp Ala Val Phe Ala 
            180                 185                 190         


Gln Asn Asp Glu Met Ala Leu Gly Ala Ile Lys Ala Ile Glu Ala Ala 
        195                 200                 205             


Asn Arg Gln Gly Ile Ile Val Val Gly Phe Asp Gly Thr Glu Asp Ala 
    210                 215                 220                 


Leu Lys Ala Ile Lys Glu Gly Lys Met Ala Ala Thr Ile Ala Gln Gln 
225                 230                 235                 240 


Pro Ala Leu Met Gly Ser Leu Gly Val Glu Met Ala Asp Lys Tyr Leu 
                245                 250                 255     


Lys Gly Glu Lys Ile Pro Asn Phe Ile Pro Ala Glu Leu Lys Leu Ile 
            260                 265                 270         


Thr Lys Glu Asn Val Gln 
        275             


<210>  3
<211>  2173
<212>  DNA
<213>  artificial sequence

<220>
<223>  Recombinant fusion protein

<400>  3
atgggcagca gccatcacca tcatcaccac agccaggatc cgaattcgag ctcgatgaaa       60

gagggcaaaa cgattggcct ggtgatctct accctgaaca atccgttctt tgtgaccctg      120

aaaaatggtg cggaagaaaa agcgaaagaa ctgggttaca aaattatcgt tgaagattcg      180

caaaatgatt cctctaaaga gctgtctaat gtcgaagatt tgattcaaca gaaagttgat      240

gttctgctga tcaatccggt ggatagcgat gcggttgtta cggcgattaa agaagcgaat      300

agcaaaaata tcccggttat taccatcgat cgcagcgcga atggtggtga tgttgtttcc      360

catatcgcca gcgataatgt taagggtggc gaaatggccg cggaatttat cgcgaaagcc      420

ctgaaaggca aggggaatgt tgtggaactg gaaggtatcc cgggggcgtc tgcggcacgt      480

gatcgcggca aagggtttga tgaagccatt gctaagtatc cggatattaa aatcgttgca      540

aagcaggcgg cggattttga tcgttccaaa ggtctgtcag tgatggaaaa catcttgcaa      600

gcccagccga aaattgatgc agtgtttgcg caaaatgatg aaatggctct gggcgctatc      660

aaagccattg aggccgcgaa tcgtcaaggt attattgttg tgggctttga tgggaccgaa      720

gatgctctga aagcgattaa agaagggaaa atggctgcga ccattgcgca gcagccggcc      780

ctgatgggct cactgggtgt ggagatggct gataaatacc tgaaaggtga aaaaattccg      840

aactttattc cggcagaact gaaactcatc acgaaagaaa atgtgcaggg tggagcggca      900

agcgggggtg ccgcgggtgg cagctctgcg gcgcgcctgc aggtcgacaa gcttgcggcc      960

gcattagaag tgctgtttca aggtccaggc atggaggagc cgcagtcaga tcctagcgtc     1020

gagccccctc tgagtcagga aacattttca gacctatgga aactacttcc tgaaaacaac     1080

gttctgtccc ccttgccgtc ccaagcaatg gatgatttga tgctgtcccc ggacgatatt     1140

gaacaatggt tcactgaaga cccaggtcca gatgaagctc ccagaatgcc agaggctgct     1200

ccccccgtgg cccctgcacc agcagctcct acaccggcgg cccctgcacc agccccctcc     1260

tggcccctgt catcttctgt cccttcccag aaaacctacc agggcagcta cggtttccgt     1320

ctgggcttct tgcattctgg gacagccaag tctgtgactt gcacgtactc ccctgccctc     1380

aacaagatgt tttgccaact ggccaagacc tgccctgtgc agctgtgggt tgattccaca     1440

cccccgcccg gcacccgcgt ccgcgccatg gccatctaca agcagtcaca gcacatgacg     1500

gaggttgtga ggcgctgccc ccaccatgag cgctgctcag atagcgatgg tctggcccct     1560

cctcagcatc ttatccgagt ggaaggaaat ttgcgtgtgg agtatttgga tgacagaaac     1620

acttttcgac atagtgtggt ggtgccctat gagccgcctg aggttggctc tgactgtacc     1680

accatccact acaactacat gtgtaacagt tcctgcatgg gcggcatgaa ccggaggccc     1740

atcctcacca tcatcacact ggaagactcc agtggtaatc tactgggacg gaacagcttt     1800

gaggtgcgtg tttgtgcctg tcctgggaga gaccggcgca cagaggaaga gaatctccgc     1860

aagaaagggg agcctcacca cgagctgccc ccagggagca ctaagcgagc actgcccaac     1920

aacaccagct cctctcccca gccaaagaag aaaccactgg atggagaata tttcaccctt     1980

cagatccgtg ggcgtgagcg cttcgagatg ttccgagagc tgaatgaggc cttggaactc     2040

aaggatgccc aggctgggaa ggagccaggg gggagcaggg ctcactccag ccacctgaag     2100

tccaaaaagg gtcagtctac ctcccgccat aaaaaactca tgttcaagac agaagggcct     2160

gactcagact gac                                                        2173


<210>  4
<211>  723
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant fusion protein

<400>  4

Met Gly Ser Ser His His His His His His Ser Gln Asp Pro Asn Ser 
1               5                   10                  15      


Ser Ser Met Lys Glu Gly Lys Thr Ile Gly Leu Val Ile Ser Thr Leu 
            20                  25                  30          


Asn Asn Pro Phe Phe Val Thr Leu Lys Asn Gly Ala Glu Glu Lys Ala 
        35                  40                  45              


Lys Glu Leu Gly Tyr Lys Ile Ile Val Glu Asp Ser Gln Asn Asp Ser 
    50                  55                  60                  


Ser Lys Glu Leu Ser Asn Val Glu Asp Leu Ile Gln Gln Lys Val Asp 
65                  70                  75                  80  


Val Leu Leu Ile Asn Pro Val Asp Ser Asp Ala Val Val Thr Ala Ile 
                85                  90                  95      


Lys Glu Ala Asn Ser Lys Asn Ile Pro Val Ile Thr Ile Asp Arg Ser 
            100                 105                 110         


Ala Asn Gly Gly Asp Val Val Ser His Ile Ala Ser Asp Asn Val Lys 
        115                 120                 125             


Gly Gly Glu Met Ala Ala Glu Phe Ile Ala Lys Ala Leu Lys Gly Lys 
    130                 135                 140                 


Gly Asn Val Val Glu Leu Glu Gly Ile Pro Gly Ala Ser Ala Ala Arg 
145                 150                 155                 160 


Asp Arg Gly Lys Gly Phe Asp Glu Ala Ile Ala Lys Tyr Pro Asp Ile 
                165                 170                 175     


Lys Ile Val Ala Lys Gln Ala Ala Asp Phe Asp Arg Ser Lys Gly Leu 
            180                 185                 190         


Ser Val Met Glu Asn Ile Leu Gln Ala Gln Pro Lys Ile Asp Ala Val 
        195                 200                 205             


Phe Ala Gln Asn Asp Glu Met Ala Leu Gly Ala Ile Lys Ala Ile Glu 
    210                 215                 220                 


Ala Ala Asn Arg Gln Gly Ile Ile Val Val Gly Phe Asp Gly Thr Glu 
225                 230                 235                 240 


Asp Ala Leu Lys Ala Ile Lys Glu Gly Lys Met Ala Ala Thr Ile Ala 
                245                 250                 255     


Gln Gln Pro Ala Leu Met Gly Ser Leu Gly Val Glu Met Ala Asp Lys 
            260                 265                 270         


Tyr Leu Lys Gly Glu Lys Ile Pro Asn Phe Ile Pro Ala Glu Leu Lys 
        275                 280                 285             


Leu Ile Thr Lys Glu Asn Val Gln Gly Gly Ala Ala Ser Gly Gly Ala 
    290                 295                 300                 


Ala Gly Gly Ser Ser Ala Ala Arg Leu Gln Val Asp Lys Leu Ala Ala 
305                 310                 315                 320 


Ala Leu Glu Val Leu Phe Gln Gly Pro Gly Met Glu Glu Pro Gln Ser 
                325                 330                 335     


Asp Pro Ser Val Glu Pro Pro Leu Ser Gln Glu Thr Phe Ser Asp Leu 
            340                 345                 350         


Trp Lys Leu Leu Pro Glu Asn Asn Val Leu Ser Pro Leu Pro Ser Gln 
        355                 360                 365             


Ala Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe 
    370                 375                 380                 


Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala 
385                 390                 395                 400 


Pro Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala 
                405                 410                 415     


Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr 
            420                 425                 430         


Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr 
        435                 440                 445             


Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe 
    450                 455                 460                 


Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr 
465                 470                 475                 480 


Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser 
                485                 490                 495     


Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys 
            500                 505                 510         


Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu 
        515                 520                 525             


Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His 
    530                 535                 540                 


Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr 
545                 550                 555                 560 


Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met 
                565                 570                 575     


Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly 
            580                 585                 590         


Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro 
        595                 600                 605             


Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu 
    610                 615                 620                 


Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn 
625                 630                 635                 640 


Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu 
                645                 650                 655     


Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg 
            660                 665                 670         


Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu 
        675                 680                 685             


Pro Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys Lys Gly 
    690                 695                 700                 


Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu Gly Pro 
705                 710                 715                 720 


Asp Ser Asp 
            


<210>  5
<211>  1227
<212>  DNA
<213>  artificial sequence

<220>
<223>  Recombinant protein coding sequence

<400>  5
atgcaccatc accaccatca cctggaagtt ctgttccagg ggcccatgga ggagccgcag       60

tcagatccta gcgtcgagcc ccctctgagt caggaaacat tttcagacct atggaaacta      120

cttcctgaaa acaacgttct gtcccccttg ccgtcccaag caatggatga tttgatgctg      180

tccccggacg atattgaaca atggttcact gaagacccag gtccagatga agctcccaga      240

atgccagagg ctgctccccc cgtggcccct gcaccagcag ctcctacacc ggcggcccct      300

gcaccagccc cctcctggcc cctgtcatct tctgtccctt cccagaaaac ctaccagggc      360

agctacggtt tccgtctggg cttcttgcat tctgggacag ccaagtctgt gacttgcacg      420

tactcccctg ccctcaacaa gatgttttgc caactggcca agacctgccc tgtgcagctg      480

tgggttgatt ccacaccccc gcccggcacc cgcgtccgcg ccatggccat ctacaagcag      540

tcacagcaca tgacggaggt tgtgaggcgc tgcccccacc atgagcgctg ctcagatagc      600

gatggtctgg cccctcctca gcatcttatc cgagtggaag gaaatttgcg tgtggagtat      660

ttggatgaca gaaacacttt tcgacatagt gtggtggtgc cctatgagcc gcctgaggtt      720

ggctctgact gtaccaccat ccactacaac tacatgtgta acagttcctg catgggcggc      780

atgaaccgga ggcccatcct caccatcatc acactggaag actccagtgg taatctactg      840

ggacggaaca gctttgaggt gcgtgtttgt gcctgtcctg ggagagaccg gcgcacagag      900

gaagagaatc tccgcaagaa aggggagcct caccacgagc tgcccccagg gagcactaag      960

cgagcactgc ccaacaacac cagctcctct ccccagccaa agaagaaacc actggatgga     1020

gaatatttca cccttcagat ccgtgggcgt gagcgcttcg agatgttccg agagctgaat     1080

gaggccttgg aactcaagga tgcccaggct gggaaggagc caggggggag cagggctcac     1140

tccagccacc tgaagtccaa aaagggtcag tctacctccc gccataaaaa actcatgttc     1200

aagacagaag ggcctgactc agactga                                         1227


<210>  6
<211>  408
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant protein

<400>  6

Met His His His His His His Leu Glu Val Leu Phe Gln Gly Pro Met 
1               5                   10                  15      


Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln Glu 
            20                  25                  30          


Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu Ser 
        35                  40                  45              


Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp Asp 
    50                  55                  60                  


Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg 
65                  70                  75                  80  


Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro Thr 
                85                  90                  95      


Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser Val 
            100                 105                 110         


Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe 
        115                 120                 125             


Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala 
    130                 135                 140                 


Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu 
145                 150                 155                 160 


Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala 
                165                 170                 175     


Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro 
            180                 185                 190         


His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His 
        195                 200                 205             


Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg 
    210                 215                 220                 


Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val 
225                 230                 235                 240 


Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser 
                245                 250                 255     


Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu 
            260                 265                 270         


Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg 
        275                 280                 285             


Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu 
    290                 295                 300                 


Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys 
305                 310                 315                 320 


Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys 
                325                 330                 335     


Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg 
            340                 345                 350         


Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala 
        355                 360                 365             


Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu 
    370                 375                 380                 


Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe 
385                 390                 395                 400 


Lys Thr Glu Gly Pro Asp Ser Asp 
                405             


<210>  7
<211>  1167
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence encoding recombinant fusion protein

<400>  7
atgtcgtact accatcacca tcaccatcac gattacgata tcccaacgac cgaaaacctg       60

tattttcagg gcgccatgga tatggtgccc atcggagccg tgcacggcgg ccatcccggc      120

gtagtgcatc cgccacagca accactgccc acggcgccca gcggcccaaa ctcgctgcag      180

ccgaactcgg tgggccagcc gggggccacc acctcctcga acagcagcgc ctccaacaag      240

agctcgctat ccgtcaagcc caactacacg ctcaagttca cgctggccgg gcacaccaag      300

gcggtgtcgg cggtcaagtt cagtccgaat ggcgagtggc tggccagctc ctccgctgat      360

aaactaatca aaatctgggg agcatacgat ggcaagttcg agaagaccat ttcgggccac      420

aagctgggca tcagcgatgt ggcctggagc tcagactcgc gactcctcgt gagcggcagt      480

gatgacaaga cgctcaaggt ctgggagctg agcaccggga agagcttgaa aactctgaag      540

ggccacagca actatgtgtt ctgctgcaac tttaatccgc agtccaatct gatcgtctcc      600

ggcagcttcg acgagagcgt tcgcatatgg gatgtgcgca ccggcaagtg tctgaagact      660

ctacccgccc attccgatcc cgtttcggcg gtacatttca atcgcgacgg atcgctgatc      720

gtgagcagca gctacgacgg cctctgtcgc atatgggaca cggccagtgg acagtgcttg      780

aaaaccctga tcgacgacga caatccgccc gtcagctttg taaagttctc gcccaatggc      840

aagtacattt tggccgccac gctggataat acgctcaagt tgtgggacta ctcgaagggc      900

aagtgcctga agacgtatac gggtcacaag aatgagaagt actgcatatt cgccaacttc      960

tcggtgacgg gaggaaagtg gatcgtgagt ggcagcgagg acaacatggt ctacatttgg     1020

aatctgcaga gcaaggaggt ggtgcaaaag ctgcagggac acaccgatac cgttctgtgc     1080

accgcctgcc atcccacgga gaacatcatt gcttccgcgg cgctcgagaa cgacaagacc     1140

atcaagctgt ggaagtcgga tacatag                                         1167


<210>  8
<211>  388
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant fusion protein

<400>  8

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Asp Met Val Pro Ile Gly 
            20                  25                  30          


Ala Val His Gly Gly His Pro Gly Val Val His Pro Pro Gln Gln Pro 
        35                  40                  45              


Leu Pro Thr Ala Pro Ser Gly Pro Asn Ser Leu Gln Pro Asn Ser Val 
    50                  55                  60                  


Gly Gln Pro Gly Ala Thr Thr Ser Ser Asn Ser Ser Ala Ser Asn Lys 
65                  70                  75                  80  


Ser Ser Leu Ser Val Lys Pro Asn Tyr Thr Leu Lys Phe Thr Leu Ala 
                85                  90                  95      


Gly His Thr Lys Ala Val Ser Ala Val Lys Phe Ser Pro Asn Gly Glu 
            100                 105                 110         


Trp Leu Ala Ser Ser Ser Ala Asp Lys Leu Ile Lys Ile Trp Gly Ala 
        115                 120                 125             


Tyr Asp Gly Lys Phe Glu Lys Thr Ile Ser Gly His Lys Leu Gly Ile 
    130                 135                 140                 


Ser Asp Val Ala Trp Ser Ser Asp Ser Arg Leu Leu Val Ser Gly Ser 
145                 150                 155                 160 


Asp Asp Lys Thr Leu Lys Val Trp Glu Leu Ser Thr Gly Lys Ser Leu 
                165                 170                 175     


Lys Thr Leu Lys Gly His Ser Asn Tyr Val Phe Cys Cys Asn Phe Asn 
            180                 185                 190         


Pro Gln Ser Asn Leu Ile Val Ser Gly Ser Phe Asp Glu Ser Val Arg 
        195                 200                 205             


Ile Trp Asp Val Arg Thr Gly Lys Cys Leu Lys Thr Leu Pro Ala His 
    210                 215                 220                 


Ser Asp Pro Val Ser Ala Val His Phe Asn Arg Asp Gly Ser Leu Ile 
225                 230                 235                 240 


Val Ser Ser Ser Tyr Asp Gly Leu Cys Arg Ile Trp Asp Thr Ala Ser 
                245                 250                 255     


Gly Gln Cys Leu Lys Thr Leu Ile Asp Asp Asp Asn Pro Pro Val Ser 
            260                 265                 270         


Phe Val Lys Phe Ser Pro Asn Gly Lys Tyr Ile Leu Ala Ala Thr Leu 
        275                 280                 285             


Asp Asn Thr Leu Lys Leu Trp Asp Tyr Ser Lys Gly Lys Cys Leu Lys 
    290                 295                 300                 


Thr Tyr Thr Gly His Lys Asn Glu Lys Tyr Cys Ile Phe Ala Asn Phe 
305                 310                 315                 320 


Ser Val Thr Gly Gly Lys Trp Ile Val Ser Gly Ser Glu Asp Asn Met 
                325                 330                 335     


Val Tyr Ile Trp Asn Leu Gln Ser Lys Glu Val Val Gln Lys Leu Gln 
            340                 345                 350         


Gly His Thr Asp Thr Val Leu Cys Thr Ala Cys His Pro Thr Glu Asn 
        355                 360                 365             


Ile Ile Ala Ser Ala Ala Leu Glu Asn Asp Lys Thr Ile Lys Leu Trp 
    370                 375                 380                 


Lys Ser Asp Thr 
385             


<210>  9
<211>  2049
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA coding sequence of recombinant fusion protein

<400>  9
atgggcagca gccatcacca tcatcaccac agccaggatc cgaattcgag ctcgatgaaa       60

gagggcaaaa cgattggcct ggtgatctct accctgaaca atccgttctt tgtgaccctg      120

aaaaatggtg cggaagaaaa agcgaaagaa ctgggttaca aaattatcgt tgaagattcg      180

caaaatgatt cctctaaaga gctgtctaat gtcgaagatt tgattcaaca gaaagttgat      240

gttctgctga tcaatccggt ggatagcgat gcggttgtta cggcgattaa agaagcgaat      300

agcaaaaata tcccggttat taccatcgat cgcagcgcga atggtggtga tgttgtttcc      360

catatcgcca gcgataatgt taagggtggc gaaatggccg cggaatttat cgcgaaagcc      420

ctgaaaggca aggggaatgt tgtggaactg gaaggtatcc cgggggcgtc tgcggcacgt      480

gatcgcggca aagggtttga tgaagccatt gctaagtatc cggatattaa aatcgttgca      540

aagcaggcgg cggattttga tcgttccaaa ggtctgtcag tgatggaaaa catcttgcaa      600

gcccagccga aaattgatgc agtgtttgcg caaaatgatg aaatggctct gggcgctatc      660

aaagccattg aggccgcgaa tcgtcaaggt attattgttg tgggctttga tgggaccgaa      720

gatgctctga aagcgattaa agaagggaaa atggctgcga ccattgcgca gcagccggcc      780

ctgatgggct cactgggtgt ggagatggct gataaatacc tgaaaggtga aaaaattccg      840

aactttattc cggcagaact gaaactcatc acgaaagaaa atgtgcaggg tggagcggca      900

agcgggggtg ccgcgggtgg cagctctgcg gccgcattag aagtgctgtt tcaaggtcca      960

ggcatggtgc ccatcggagc cgtgcacggc ggccatcccg gcgtagtgca tccgccacag     1020

caaccactgc ccacggcgcc cagcggccca aactcgctgc agccgaactc ggtgggccag     1080

ccgggggcca ccacctcctc gaacagcagc gcctccaaca agagctcgct atccgtcaag     1140

cccaactaca cgctcaagtt cacgctggcc gggcacacca aggcggtgtc ggcggtcaag     1200

ttcagtccga atggcgagtg gctggccagc tcctccgctg ataaactaat caaaatctgg     1260

ggagcatacg atggcaagtt cgagaagacc atttcgggcc acaagctggg catcagcgat     1320

gtggcctgga gctcagactc gcgactcctc gtgagcggca gtgatgacaa gacgctcaag     1380

gtctgggagc tgagcaccgg gaagagcttg aaaactctga agggccacag caactatgtg     1440

ttctgctgca actttaatcc gcagtccaat ctgatcgtct ccggcagctt cgacgagagc     1500

gttcgcatat gggatgtgcg caccggcaag tgtctgaaga ctctacccgc ccattccgat     1560

cccgtttcgg cggtacattt caatcgcgac ggatcgctga tcgtgagcag cagctacgac     1620

ggcctctgtc gcatatggga cacggccagt ggacagtgct tgaaaaccct gatcgacgac     1680

gacaatccgc ccgtcagctt tgtaaagttc tcgcccaatg gcaagtacat tttggccgcc     1740

acgctggata atacgctcaa gttgtgggac tactcgaagg gcaagtgcct gaagacgtat     1800

acgggtcaca agaatgagaa gtactgcata ttcgccaact tctcggtgac gggaggaaag     1860

tggatcgtga gtggcagcga ggacaacatg gtctacattt ggaatctgca gagcaaggag     1920

gtggtgcaaa agctgcaggg acacaccgat accgttctgt gcaccgcctg ccatcccacg     1980

gagaacatca ttgcttccgc ggcgctcgag aacgacaaga ccatcaagct gtggaagtcg     2040

gatacatag                                                             2049


<210>  10
<211>  616
<212>  PRT
<213>  artificial sequence

<220>
<223>  Amino acid sequence of recombinant fusion protein

<400>  10

Met Gly Ser Ser His His His His His His Ser Gln Asp Pro Asn Ser 
1               5                   10                  15      


Ser Ser Met Lys Glu Gly Lys Thr Ile Gly Leu Val Ile Ser Thr Leu 
            20                  25                  30          


Asn Asn Pro Phe Phe Val Thr Leu Lys Asn Gly Ala Glu Glu Lys Ala 
        35                  40                  45              


Lys Glu Leu Gly Tyr Lys Ile Ile Val Glu Asp Ser Gln Asn Asp Ser 
    50                  55                  60                  


Ser Lys Glu Leu Ser Asn Val Glu Asp Leu Ile Gln Gln Lys Val Asp 
65                  70                  75                  80  


Val Leu Leu Ile Asn Pro Val Asp Ser Asp Ala Val Val Thr Ala Ile 
                85                  90                  95      


Lys Glu Ala Asn Ser Lys Asn Ile Pro Val Ile Thr Ile Asp Arg Ser 
            100                 105                 110         


Ala Asn Gly Gly Asp Val Val Ser His Ile Ala Ser Asp Asn Val Lys 
        115                 120                 125             


Gly Gly Glu Met Ala Ala Glu Phe Ile Ala Lys Ala Leu Lys Gly Lys 
    130                 135                 140                 


Gly Asn Val Val Glu Leu Glu Gly Ile Pro Gly Ala Ser Ala Ala Arg 
145                 150                 155                 160 


Asp Arg Gly Lys Gly Phe Asp Glu Ala Ile Ala Lys Tyr Pro Asp Ile 
                165                 170                 175     


Lys Ile Val Ala Lys Gln Ala Ala Asp Phe Asp Arg Ser Lys Gly Leu 
            180                 185                 190         


Ser Val Met Glu Asn Ile Leu Gln Ala Gln Pro Lys Ile Asp Ala Val 
        195                 200                 205             


Phe Ala Gln Asn Asp Glu Met Ala Leu Gly Ala Ile Lys Ala Ile Glu 
    210                 215                 220                 


Ala Ala Asn Arg Gln Gly Ile Ile Val Val Gly Phe Asp Gly Thr Glu 
225                 230                 235                 240 


Asp Ala Leu Lys Ala Ile Lys Glu Gly Lys Met Ala Ala Thr Ile Ala 
                245                 250                 255     


Gln Gln Pro Ala Leu Met Gly Ser Leu Gly Val Glu Met Ala Asp Lys 
            260                 265                 270         


Tyr Leu Lys Gly Glu Lys Ile Pro Asn Phe Ile Pro Ala Glu Leu Lys 
        275                 280                 285             


Leu Ile Thr Lys Glu Asn Val Gln Gly Gly Ala Ala Ser Gly Gly Ala 
    290                 295                 300                 


Ala Gly Gly Ser Ser Ala Ala Ala Leu Glu Val Leu Phe Gln Gly Pro 
305                 310                 315                 320 


Gly Met Val Pro Ile Gly Ala Val His Gly Gly His Pro Gly Val Val 
                325                 330                 335     


His Pro Pro Gln Gln Pro Leu Pro Thr Ala Pro Ser Gly Pro Asn Ser 
            340                 345                 350         


Leu Gln Pro Asn Ser Val Gly Gln Pro Gly Ala Thr Thr Ser Ser Asn 
        355                 360                 365             


Ser Ser Ala Ser Asn Lys Ser Ser Leu Ser Val Lys Pro Asn Tyr Thr 
    370                 375                 380                 


Leu Lys Phe Thr Leu Ala Gly His Thr Lys Ala Val Ser Ala Val Lys 
385                 390                 395                 400 


Phe Ser Pro Asn Gly Glu Trp Leu Ala Ser Ser Ser Ala Asp Lys Leu 
                405                 410                 415     


Ile Lys Ile Trp Gly Ala Tyr Asp Gly Lys Phe Glu Lys Thr Ile Ser 
            420                 425                 430         


Gly His Lys Leu Gly Ile Ser Asp Val Ala Trp Ser Ser Asp Ser Arg 
        435                 440                 445             


Leu Leu Val Ser Gly Ser Asp Asp Lys Thr Leu Lys Val Trp Glu Leu 
    450                 455                 460                 


Ser Thr Gly Lys Ser Leu Lys Thr Leu Lys Gly His Ser Asn Tyr Val 
465                 470                 475                 480 


Phe Cys Cys Asn Phe Asn Pro Gln Ser Asn Leu Ile Val Ser Gly Ser 
                485                 490                 495     


Phe Asp Glu Ser Val Arg Ile Trp Asp Val Arg Thr Gly Lys Cys Leu 
            500                 505                 510         


Lys Thr Leu Pro Ala His Ser Asp Pro Val Ser Ala Val His Phe Asn 
        515                 520                 525             


Arg Asp Gly Ser Leu Ile Val Ser Ser Ser Tyr Asp Gly Leu Cys Arg 
    530                 535                 540                 


Ile Trp Asp Thr Ala Ser Gly Gln Cys Leu Lys Thr Leu Ile Asp Asp 
545                 550                 555                 560 


Asp Asn Pro Pro Val Ser Phe Val Lys Phe Ser Pro Asn Gly Lys Tyr 
                565                 570                 575     


Ile Leu Ala Ala Thr Leu Asp Asn Thr Leu Lys Leu Trp Asp Tyr Ser 
            580                 585                 590         


Lys Gly Lys Cys Leu Lys Thr Tyr Ala Ala Leu Glu Asn Asp Lys Thr 
        595                 600                 605             


Ile Lys Leu Trp Lys Ser Asp Thr 
    610                 615     


<210>  11
<211>  2091
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA coding sequence for recombinant fusion protein

<400>  11
atgggcagca gccatcacca tcatcaccac agccaggatc cgaattcgag ctcgatgaaa       60

gagggcaaaa cgattggcct ggtgatctct accctgaaca atccgttctt tgtgaccctg      120

aaaaatggtg cggaagaaaa agcgaaagaa ctgggttaca aaattatcgt tgaagattcg      180

caaaatgatt cctctaaaga gctgtctaat gtcgaagatt tgattcaaca gaaagttgat      240

gttctgctga tcaatccggt ggatagcgat gcggttgtta cggcgattaa agaagcgaat      300

agcaaaaata tcccggttat taccatcgat cgcagcgcga atggtggtga tgttgtttcc      360

catatcgcca gcgataatgt taagggtggc gaaatggccg cggaatttat cgcgaaagcc      420

ctgaaaggca aggggaatgt tgtggaactg gaaggtatcc cgggggcgtc tgcggcacgt      480

gatcgcggca aagggtttga tgaagccatt gctaagtatc cggatattaa aatcgttgca      540

aagcaggcgg cggattttga tcgttccaaa ggtctgtcag tgatggaaaa catcttgcaa      600

gcccagccga aaattgatgc agtgtttgcg caaaatgatg aaatggctct gggcgctatc      660

aaagccattg aggccgcgaa tcgtcaaggt attattgttg tgggctttga tgggaccgaa      720

gatgctctga aagcgattaa agaagggaaa atggctgcga ccattgcgca gcagccggcc      780

ctgatgggct cactgggtgt ggagatggct gataaatacc tgaaaggtga aaaaattccg      840

aactttattc cggcagaact gaaactcatc acgaaagaaa atgtgcaggg tggagcggca      900

agcgggggtg ccgcgggtgg cagctctgcg gccgcattag aagtgctgtt tcaaggtcca      960

ggcatggatt ctgaggttgc tgctttggtt attgataacg gttctggtat gtgtaaagcc     1020

ggttttgccg gtgacgacgc tcctcgtgct gtcttcccat ctatcgtcgg tagaccaaga     1080

caccaaggta tcatggtcgg tatgggtcaa aaagactcct acgttggtga tgaagctcaa     1140

tccaagagag gtatcttgac tttacgttac ccaattgaac acggtattgt caccaactgg     1200

gacgatatgg aaaagatctg gcatcatacc ttctacaacg aattgagagt tgccccagaa     1260

gaacaccctg ttcttttgac tgaagctcca atgaacccta aatcaaacag agaaaagatg     1320

actcaaatta tgtttgaaac tttcaacgtt ccagccttct acgtttccat ccaagccgtt     1380

ttgtccttgt actcttccgg tagaactact ggtattgttt tggattccgg tgatggtgtt     1440

actcacgtcg ttccaattta cgctggtttc tctctacctc acgccatttt gagaatcgat     1500

ttggccggta gagatttgac tgactacttg atgaagatct tgagtgaacg tggttactct     1560

ttctccacca ctgctgaaag agaaattgtc cgtgacatca aggaaaaact atgttacgtc     1620

gccttggact tcgaacaaga aatgcaaacc gctgctcaat cttcttcaat tgaaaaatcc     1680

tacgaacttc cagatggtca agtcatcact attggtaacg aaagattcag agccccagaa     1740

gctttgttcc atccttctgt tttgggtttg gaatctgccg gtattgacca aactacttac     1800

aactccatca tgaagtgtga tgtcgatgtc cgtaaggaat tatacggtaa catcgttatg     1860

tccggtggta ccaccatgtt cccaggtatt gccgaaagaa tgcaaaagga aatcaccgct     1920

ttggctccat cttccatgaa ggtcaagatc attgctcctc cagaaagaaa gtactccgtc     1980

tggattggtg gttctatctt ggcttctttg actaccttcc aacaaatgtg gatctcaaaa     2040

caagaatacg acgaaagtgg tccatctatc gttcaccaca agtgtttcta a              2091


<210>  12
<211>  696
<212>  PRT
<213>  artificial sequence

<220>
<223>  Amino acid sequence of recombinant fusion protein

<400>  12

Met Gly Ser Ser His His His His His His Ser Gln Asp Pro Asn Ser 
1               5                   10                  15      


Ser Ser Met Lys Glu Gly Lys Thr Ile Gly Leu Val Ile Ser Thr Leu 
            20                  25                  30          


Asn Asn Pro Phe Phe Val Thr Leu Lys Asn Gly Ala Glu Glu Lys Ala 
        35                  40                  45              


Lys Glu Leu Gly Tyr Lys Ile Ile Val Glu Asp Ser Gln Asn Asp Ser 
    50                  55                  60                  


Ser Lys Glu Leu Ser Asn Val Glu Asp Leu Ile Gln Gln Lys Val Asp 
65                  70                  75                  80  


Val Leu Leu Ile Asn Pro Val Asp Ser Asp Ala Val Val Thr Ala Ile 
                85                  90                  95      


Lys Glu Ala Asn Ser Lys Asn Ile Pro Val Ile Thr Ile Asp Arg Ser 
            100                 105                 110         


Ala Asn Gly Gly Asp Val Val Ser His Ile Ala Ser Asp Asn Val Lys 
        115                 120                 125             


Gly Gly Glu Met Ala Ala Glu Phe Ile Ala Lys Ala Leu Lys Gly Lys 
    130                 135                 140                 


Gly Asn Val Val Glu Leu Glu Gly Ile Pro Gly Ala Ser Ala Ala Arg 
145                 150                 155                 160 


Asp Arg Gly Lys Gly Phe Asp Glu Ala Ile Ala Lys Tyr Pro Asp Ile 
                165                 170                 175     


Lys Ile Val Ala Lys Gln Ala Ala Asp Phe Asp Arg Ser Lys Gly Leu 
            180                 185                 190         


Ser Val Met Glu Asn Ile Leu Gln Ala Gln Pro Lys Ile Asp Ala Val 
        195                 200                 205             


Phe Ala Gln Asn Asp Glu Met Ala Leu Gly Ala Ile Lys Ala Ile Glu 
    210                 215                 220                 


Ala Ala Asn Arg Gln Gly Ile Ile Val Val Gly Phe Asp Gly Thr Glu 
225                 230                 235                 240 


Asp Ala Leu Lys Ala Ile Lys Glu Gly Lys Met Ala Ala Thr Ile Ala 
                245                 250                 255     


Gln Gln Pro Ala Leu Met Gly Ser Leu Gly Val Glu Met Ala Asp Lys 
            260                 265                 270         


Tyr Leu Lys Gly Glu Lys Ile Pro Asn Phe Ile Pro Ala Glu Leu Lys 
        275                 280                 285             


Leu Ile Thr Lys Glu Asn Val Gln Gly Gly Ala Ala Ser Gly Gly Ala 
    290                 295                 300                 


Ala Gly Gly Ser Ser Ala Ala Ala Leu Glu Val Leu Phe Gln Gly Pro 
305                 310                 315                 320 


Gly Met Asp Ser Glu Val Ala Ala Leu Val Ile Asp Asn Gly Ser Gly 
                325                 330                 335     


Met Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe 
            340                 345                 350         


Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Ile Met Val Gly Met 
        355                 360                 365             


Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly 
    370                 375                 380                 


Ile Leu Thr Leu Arg Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp 
385                 390                 395                 400 


Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg 
                405                 410                 415     


Val Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Met Asn 
            420                 425                 430         


Pro Lys Ser Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe 
        435                 440                 445             


Asn Val Pro Ala Phe Tyr Val Ser Ile Gln Ala Val Leu Ser Leu Tyr 
    450                 455                 460                 


Ser Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly Val 
465                 470                 475                 480 


Thr His Val Val Pro Ile Tyr Ala Gly Phe Ser Leu Pro His Ala Ile 
                485                 490                 495     


Leu Arg Ile Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys 
            500                 505                 510         


Ile Leu Ser Glu Arg Gly Tyr Ser Phe Ser Thr Thr Ala Glu Arg Glu 
        515                 520                 525             


Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe 
    530                 535                 540                 


Glu Gln Glu Met Gln Thr Ala Ala Gln Ser Ser Ser Ile Glu Lys Ser 
545                 550                 555                 560 


Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe 
                565                 570                 575     


Arg Ala Pro Glu Ala Leu Phe His Pro Ser Val Leu Gly Leu Glu Ser 
            580                 585                 590         


Ala Gly Ile Asp Gln Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp Val 
        595                 600                 605             


Asp Val Arg Lys Glu Leu Tyr Gly Asn Ile Val Met Ser Gly Gly Thr 
    610                 615                 620                 


Thr Met Phe Pro Gly Ile Ala Glu Arg Met Gln Lys Glu Ile Thr Ala 
625                 630                 635                 640 


Leu Ala Pro Ser Ser Met Lys Val Lys Ile Ile Ala Pro Pro Glu Arg 
                645                 650                 655     


Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Thr Thr 
            660                 665                 670         


Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro 
        675                 680                 685             


Ser Ile Val His His Lys Cys Phe 
    690                 695     


<210>  13
<211>  495
<212>  PRT
<213>  artificial sequence

<220>
<223>  Amino acid sequence of recombinant fusion protein

<400>  13

Met Gly Ser Ser His His His His His His Ser Gln Asp Pro Asn Ser 
1               5                   10                  15      


Ser Ser Met Lys Glu Gly Lys Thr Ile Gly Leu Val Ile Ser Thr Leu 
            20                  25                  30          


Asn Asn Pro Phe Phe Val Thr Leu Lys Asn Gly Ala Glu Glu Lys Ala 
        35                  40                  45              


Lys Glu Leu Gly Tyr Lys Ile Ile Val Glu Asp Ser Gln Asn Asp Ser 
    50                  55                  60                  


Ser Lys Glu Leu Ser Asn Val Glu Asp Leu Ile Gln Gln Lys Val Asp 
65                  70                  75                  80  


Val Leu Leu Ile Asn Pro Val Asp Ser Asp Ala Val Val Thr Ala Ile 
                85                  90                  95      


Lys Glu Ala Asn Ser Lys Asn Ile Pro Val Ile Thr Ile Asp Arg Ser 
            100                 105                 110         


Ala Asn Gly Gly Asp Val Val Ser His Ile Ala Ser Asp Asn Val Lys 
        115                 120                 125             


Gly Gly Glu Met Ala Ala Glu Phe Ile Ala Lys Ala Leu Lys Gly Lys 
    130                 135                 140                 


Gly Asn Val Val Glu Leu Glu Gly Ile Pro Gly Ala Ser Ala Ala Arg 
145                 150                 155                 160 


Asp Arg Gly Lys Gly Phe Asp Glu Ala Ile Ala Lys Tyr Pro Asp Ile 
                165                 170                 175     


Lys Ile Val Ala Lys Gln Ala Ala Asp Phe Asp Arg Ser Lys Gly Leu 
            180                 185                 190         


Ser Val Met Glu Asn Ile Leu Gln Ala Gln Pro Lys Ile Asp Ala Val 
        195                 200                 205             


Phe Ala Gln Asn Asp Glu Met Ala Leu Gly Ala Ile Lys Ala Ile Glu 
    210                 215                 220                 


Ala Ala Asn Arg Gln Gly Ile Ile Val Val Gly Phe Asp Gly Thr Glu 
225                 230                 235                 240 


Asp Ala Leu Lys Ala Ile Lys Glu Gly Lys Met Ala Ala Thr Ile Ala 
                245                 250                 255     


Gln Gln Pro Ala Leu Met Gly Ser Leu Gly Val Glu Met Ala Asp Lys 
            260                 265                 270         


Tyr Leu Lys Gly Glu Lys Ile Pro Asn Phe Ile Pro Ala Glu Leu Lys 
        275                 280                 285             


Leu Ile Thr Lys Glu Asn Val Gln Gly Gly Ala Ala Ser Gly Gly Ala 
    290                 295                 300                 


Ala Gly Gly Ser Ser Ala Ala Ala Gly Gly Pro Asn Thr Glu Phe Ala 
305                 310                 315                 320 


Leu Ser Leu Leu Arg Lys Asn Ile Met Thr Ile Thr Thr Ser Lys Gly 
                325                 330                 335     


Glu Phe Thr Gly Leu Gly Ile His Asp Arg Val Cys Val Ile Pro Thr 
            340                 345                 350         


His Ala Gln Pro Gly Asp Asp Val Leu Val Asn Gly Gln Lys Ile Arg 
        355                 360                 365             


Val Lys Asp Lys Tyr Lys Leu Val Asp Pro Glu Asn Ile Asn Leu Glu 
    370                 375                 380                 


Leu Thr Val Leu Thr Leu Asp Arg Asn Glu Lys Phe Arg Asp Ile Arg 
385                 390                 395                 400 


Gly Phe Ile Ser Glu Asp Leu Glu Gly Val Asp Ala Thr Leu Val Val 
                405                 410                 415     


His Ser Asn Asn Phe Thr Asn Thr Ile Leu Glu Val Gly Pro Val Thr 
            420                 425                 430         


Met Ala Gly Leu Ile Asn Leu Ser Ser Thr Pro Thr Asn Arg Met Ile 
        435                 440                 445             


Arg Tyr Asp Tyr Ala Thr Lys Thr Gly Gln Cys Gly Gly Val Leu Cys 
    450                 455                 460                 


Ala Thr Gly Lys Ile Phe Gly Ile His Val Gly Gly Asn Gly Arg Gln 
465                 470                 475                 480 


Gly Phe Ser Ala Gln Leu Lys Lys Gln Tyr Phe Val Glu Lys Gln 
                485                 490                 495 


<210>  14
<211>  1488
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA coding sequence for recombinant fusion protein

<400>  14
atgggcagca gccatcacca tcatcaccac agccaggatc cgaattcgag ctcgatgaaa       60

gagggcaaaa cgattggcct ggtgatctct accctgaaca atccgttctt tgtgaccctg      120

aaaaatggtg cggaagaaaa agcgaaagaa ctgggttaca aaattatcgt tgaagattcg      180

caaaatgatt cctctaaaga gctgtctaat gtcgaagatt tgattcaaca gaaagttgat      240

gttctgctga tcaatccggt ggatagcgat gcggttgtta cggcgattaa agaagcgaat      300

agcaaaaata tcccggttat taccatcgat cgcagcgcga atggtggtga tgttgtttcc      360

catatcgcca gcgataatgt taagggtggc gaaatggccg cggaatttat cgcgaaagcc      420

ctgaaaggca aggggaatgt tgtggaactg gaaggtatcc cgggggcgtc tgcggcacgt      480

gatcgcggca aagggtttga tgaagccatt gctaagtatc cggatattaa aatcgttgca      540

aagcaggcgg cggattttga tcgttccaaa ggtctgtcag tgatggaaaa catcttgcaa      600

gcccagccga aaattgatgc agtgtttgcg caaaatgatg aaatggctct gggcgctatc      660

aaagccattg aggccgcgaa tcgtcaaggt attattgttg tgggctttga tgggaccgaa      720

gatgctctga aagcgattaa agaagggaaa atggctgcga ccattgcgca gcagccggcc      780

ctgatgggct cactgggtgt ggagatggct gataaatacc tgaaaggtga aaaaattccg      840

aactttattc cggcagaact gaaactcatc acgaaagaaa atgtgcaggg tggagcggca      900

agcgggggtg ccgcgggtgg cagctctgcg gccgcaggcg gaccaaacac agaatttgca      960

ctatccctgt taaggaaaaa cataatgact ataacaacct caaagggaga gttcacaggg     1020

ttaggcatac atgatcgtgt ctgtgtgata cccacacacg cacagcctgg tgatgatgta     1080

ctagtgaatg gtcagaaaat tagagttaag gataagtaca aattagtaga tccagagaac     1140

attaatctag agcttacagt gttgacttta gatagaaatg aaaaattcag agatatcagg     1200

ggatttatat cagaagatct agaaggtgtg gatgccactt tggtagtaca ttcaaataac     1260

tttaccaaca ctatcttaga agttggccct gtaacaatgg caggacttat taatttgagt     1320

agcaccccca ctaacagaat gattcgttat gattatgcaa caaaaactgg gcagtgtgga     1380

ggtgtgctgt gtgctactgg taagatcttt ggtattcatg ttggcggtaa tggaagacaa     1440

ggattttcag ctcaacttaa aaaacaatat tttgtagaga aacaataa                  1488


<210>  15
<211>  821
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant fusion protein

<400>  15

Met Gly Ser Ser His His His His His His Ser Gln Asp Pro Asn Ser 
1               5                   10                  15      


Ser Ser Met Lys Glu Gly Lys Thr Ile Gly Leu Val Ile Ser Thr Leu 
            20                  25                  30          


Asn Asn Pro Phe Phe Val Thr Leu Lys Asn Gly Ala Glu Glu Lys Ala 
        35                  40                  45              


Lys Glu Leu Gly Tyr Lys Ile Ile Val Glu Asp Ser Gln Asn Asp Ser 
    50                  55                  60                  


Ser Lys Glu Leu Ser Asn Val Glu Asp Leu Ile Gln Gln Lys Val Asp 
65                  70                  75                  80  


Val Leu Leu Ile Asn Pro Val Asp Ser Asp Ala Val Val Thr Ala Ile 
                85                  90                  95      


Lys Glu Ala Asn Ser Lys Asn Ile Pro Val Ile Thr Ile Asp Arg Ser 
            100                 105                 110         


Ala Asn Gly Gly Asp Val Val Ser His Ile Ala Ser Asp Asn Val Lys 
        115                 120                 125             


Gly Gly Glu Met Ala Ala Glu Phe Ile Ala Lys Ala Leu Lys Gly Lys 
    130                 135                 140                 


Gly Asn Val Val Glu Leu Glu Gly Ile Pro Gly Ala Ser Ala Ala Arg 
145                 150                 155                 160 


Asp Arg Gly Lys Gly Phe Asp Glu Ala Ile Ala Lys Tyr Pro Asp Ile 
                165                 170                 175     


Lys Ile Val Ala Lys Gln Ala Ala Asp Phe Asp Arg Ser Lys Gly Leu 
            180                 185                 190         


Ser Val Met Glu Asn Ile Leu Gln Ala Gln Pro Lys Ile Asp Ala Val 
        195                 200                 205             


Phe Ala Gln Asn Asp Glu Met Ala Leu Gly Ala Ile Lys Ala Ile Glu 
    210                 215                 220                 


Ala Ala Asn Arg Gln Gly Ile Ile Val Val Gly Phe Asp Gly Thr Glu 
225                 230                 235                 240 


Asp Ala Leu Lys Ala Ile Lys Glu Gly Lys Met Ala Ala Thr Ile Ala 
                245                 250                 255     


Gln Gln Pro Ala Leu Met Gly Ser Leu Gly Val Glu Met Ala Asp Lys 
            260                 265                 270         


Tyr Leu Lys Gly Glu Lys Ile Pro Asn Phe Ile Pro Ala Glu Leu Lys 
        275                 280                 285             


Leu Ile Thr Lys Glu Asn Val Gln Gly Gly Ala Ala Ser Gly Gly Ala 
    290                 295                 300                 


Ala Gly Gly Ser Ser Ala Ala Arg Leu Gln Val Asp Lys Leu Ala Ala 
305                 310                 315                 320 


Ala Leu Glu Val Leu Phe Gln Gly Pro Gly Met Cys Asn Thr Asn Met 
                325                 330                 335     


Ser Val Pro Thr Asp Gly Ala Val Thr Thr Ser Gln Ile Pro Ala Ser 
            340                 345                 350         


Glu Gln Glu Thr Leu Val Arg Pro Lys Pro Leu Leu Leu Lys Leu Leu 
        355                 360                 365             


Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr Thr Met Lys Glu Val Leu 
    370                 375                 380                 


Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys Arg Leu Tyr Asp Glu Lys 
385                 390                 395                 400 


Gln Gln His Ile Val Tyr Cys Ser Asn Asp Leu Leu Gly Asp Leu Phe 
                405                 410                 415     


Gly Val Pro Ser Phe Ser Val Lys Glu His Arg Lys Ile Tyr Thr Met 
            420                 425                 430         


Ile Tyr Arg Asn Leu Val Val Val Asn Gln Gln Glu Ser Ser Asp Ser 
        435                 440                 445             


Gly Thr Ser Val Ser Glu Asn Arg Cys His Leu Glu Gly Gly Ser Asp 
    450                 455                 460                 


Gln Lys Asp Leu Val Gln Glu Leu Gln Glu Glu Lys Pro Ser Ser Ser 
465                 470                 475                 480 


His Leu Val Ser Arg Pro Ser Thr Ser Ser Arg Arg Arg Ala Ile Ser 
                485                 490                 495     


Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser Gly Glu Arg Gln Arg Lys 
            500                 505                 510         


Arg His Lys Ser Asp Ser Ile Ser Leu Ser Phe Asp Glu Ser Leu Ala 
        515                 520                 525             


Leu Cys Val Ile Arg Glu Ile Cys Cys Glu Arg Ser Ser Ser Ser Glu 
    530                 535                 540                 


Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu Asp Ala Gly Val Ser Glu 
545                 550                 555                 560 


His Ser Gly Asp Trp Leu Asp Gln Asp Ser Val Ser Asp Gln Phe Ser 
                565                 570                 575     


Val Glu Phe Glu Val Glu Ser Leu Asp Ser Glu Asp Tyr Ser Leu Ser 
            580                 585                 590         


Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp Asp Glu Val Tyr Gln Val 
        595                 600                 605             


Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr Asp Ser Phe Glu Glu Asp 
    610                 615                 620                 


Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu 
625                 630                 635                 640 


Met Asn Pro Pro Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg 
                645                 650                 655     


Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser 
            660                 665                 670         


Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp 
        675                 680                 685             


Val Pro Asp Cys Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys 
    690                 695                 700                 


Val Glu Glu Asn Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu 
705                 710                 715                 720 


Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser 
                725                 730                 735     


Ser Gln Glu Asp Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys 
            740                 745                 750         


Glu Glu Ser Val Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys 
        755                 760                 765             


Val Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys 
    770                 775                 780                 


Thr Gly His Leu Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys 
785                 790                 795                 800 


Arg Asn Lys Pro Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val 
                805                 810                 815     


Leu Thr Tyr Phe Pro 
            820     


<210>  16
<211>  2539
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA sequence encoding recombinant fusion protein

<400>  16
ccatgggcag cagccatcac catcatcacc acagccagga tccgaattcg agctcgatga       60

aagagggcaa aacgattggc ctggtgatct ctaccctgaa caatccgttc tttgtgaccc      120

tgaaaaatgg tgcggaagaa aaagcgaaag aactgggtta caaaattatc gttgaagatt      180

cgcaaaatga ttcctctaaa gagctgtcta atgtcgaaga tttgattcaa cagaaagttg      240

atgttctgct gatcaatccg gtggatagcg atgcggttgt tacggcgatt aaagaagcga      300

atagcaaaaa tatcccggtt attaccatcg atcgcagcgc gaatggtggt gatgttgttt      360

cccatatcgc cagcgataat gttaagggtg gcgaaatggc cgcggaattt atcgcgaaag      420

ccctgaaagg caaggggaat gttgtggaac tggaaggtat cccgggggcg tctgcggcac      480

gtgatcgcgg caaagggttt gatgaagcca ttgctaagta tccggatatt aaaatcgttg      540

caaagcaggc ggcggatttt gatcgttcca aaggtctgtc agtgatggaa aacatcttgc      600

aagcccagcc gaaaattgat gcagtgtttg cgcaaaatga tgaaatggct ctgggcgcta      660

tcaaagccat tgaggccgcg aatcgtcaag gtattattgt tgtgggcttt gatgggaccg      720

aagatgctct gaaagcgatt aaagaaggga aaatggctgc gaccattgcg cagcagccgg      780

ccctgatggg ctcactgggt gtggagatgg ctgataaata cctgaaaggt gaaaaaattc      840

cgaactttat tccggcagaa ctgaaactca tcacgaaaga aaatgtgcag ggtggagcgg      900

caagcggggg tgccgcgggt ggcagctctg cggcgcgcct gcaggtcgac aagcttgcgg      960

ccgcattaga agtgctgttt caaggtccag gcatgtgcaa taccaacatg tctgtaccta     1020

ctgatggtgc tgtaaccacc tcacagattc cagcttcgga acaagagacc ctggttagac     1080

caaagccatt gcttttgaag ttattaaagt ctgttggtgc acaaaaagac acttatacta     1140

tgaaagaggt tcttttttat cttggccagt atattatgac taaacgatta tatgatgaga     1200

agcaacaaca tattgtatat tgttcaaatg atcttctagg agatttgttt ggcgtgccaa     1260

gcttctctgt gaaagagcac aggaaaatat ataccatgat ctacaggaac ttggtagtag     1320

tcaatcagca ggaatcatcg gactcaggta catctgtgag tgagaacagg tgtcaccttg     1380

aaggtgggag tgatcaaaag gaccttgtac aagagcttca ggaagagaaa ccttcatctt     1440

cacatttggt ttctagacca tctacctcat ctagaaggag agcaattagt gagacagaag     1500

aaaattcaga tgaattatct ggtgaacgac aaagaaaacg ccacaaatct gatagtattt     1560

ccctttcctt tgatgaaagc ctggctctgt gtgtaataag ggagatatgt tgtgaaagaa     1620

gcagtagcag tgaatctaca gggacgccat cgaatccgga tcttgatgct ggtgtaagtg     1680

aacattcagg tgattggttg gatcaggatt cagtttcaga tcagtttagt gtagaatttg     1740

aagttgaatc tctcgactca gaagattata gccttagtga agaaggacaa gaactctcag     1800

atgaagatga tgaggtatat caagttactg tgtatcaggc aggggagagt gatacagatt     1860

catttgaaga agatcctgaa atttccttag ctgactattg gaaatgcact tcatgcaatg     1920

aaatgaatcc cccccttcca tcacattgca acagatgttg ggcccttcgt gagaattggc     1980

ttcctgaaga taaagggaaa gataaagggg aaatctctga gaaagccaaa ctggaaaact     2040

caacacaagc tgaagagggc tttgatgttc ctgattgtaa aaaaactata gtgaatgatt     2100

ccagagagtc atgtgttgag gaaaatgatg ataaaattac acaagcttca caatcacaag     2160

aaagtgaaga ctattctcag ccatcaactt ctagtagcat tatttatagc agccaagaag     2220

atgtgaaaga gtttgaaagg gaagaaaccc aagacaaaga agagagtgtg gaatctagtt     2280

tgccccttaa tgccattgaa ccttgtgtga tttgtcaagg tcgacctaaa aatggttgca     2340

ttgtccatgg caaaacagga catcttatgg cctgctttac atgtgcaaag aagctaaaga     2400

aaaggaataa gccctgccca gtatgtagac aaccaattca aatgattgtg ctaacttatt     2460

tcccctagct cgagtctggt aaagaaaccg ctgctgcgaa atttgaacgc cagcacatgg     2520

actcgtctac tagcgcagc                                                  2539


<210>  17
<211>  35
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion polypeptide fragment not included

<400>  17

Arg Lys Ser Arg Ile Leu Leu Leu Leu Thr Ile Phe Val Thr Ser Ala 
1               5                   10                  15      


Ala Leu Ile Leu Ser Gly Cys Lys Thr Asn Thr Pro Asn Thr Ala Ser 
            20                  25                  30          


Thr Ser Thr 
        35  


