                         SEQUENCE LISTING

<110>  National institute for biotechnology of the negev
 
<120>  METHODS AND KITS FOR DETERMINING DEACYLASE ACTIVITY

<130>  NIBN-P-011

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  682
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  1

Met Ala Asp Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala 
1               5                   10                  15      


Thr Ala Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro 
            20                  25                  30          


Ser Arg Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp 
        35                  40                  45              


Asp Glu Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr 
    50                  55                  60                  


Arg Asp Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His 
65                  70                  75                  80  


Ser Cys Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser 
                85                  90                  95      


Asp Trp Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln 
            100                 105                 110         


His Leu Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu 
        115                 120                 125             


Pro Glu Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln 
    130                 135                 140                 


Ile Val Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys 
145                 150                 155                 160 


Asp Ile Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys 
                165                 170                 175     


Lys Ile Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile 
            180                 185                 190         


Pro Asp Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp 
        195                 200                 205             


Phe Pro Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe 
    210                 215                 220                 


Arg Lys Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro 
225                 230                 235                 240 


Gly Gln Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp 
                245                 250                 255     


Lys Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu 
            260                 265                 270         


Glu Gln Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe 
        275                 280                 285             


Ala Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala 
    290                 295                 300                 


Val Arg Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys 
305                 310                 315                 320 


Pro Ala Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe 
                325                 330                 335     


Gly Glu Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys 
            340                 345                 350         


Asp Glu Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg 
        355                 360                 365             


Pro Val Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile 
    370                 375                 380                 


Leu Ile Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu 
385                 390                 395                 400 


Leu Gly Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly 
                405                 410                 415     


Gly Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile 
            420                 425                 430         


Thr Glu Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu 
        435                 440                 445             


Leu Pro Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu 
    450                 455                 460                 


Arg Thr Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln 
465                 470                 475                 480 


Ala Ala Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys 
                485                 490                 495     


Met Glu Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser 
            500                 505                 510         


Ile Ala Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser 
        515                 520                 525             


Thr Gly Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys 
    530                 535                 540                 


Cys Trp Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp 
545                 550                 555                 560 


Gly Asn Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly 
                565                 570                 575     


Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser 
            580                 585                 590         


Cys Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu 
        595                 600                 605             


Glu Pro Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu 
    610                 615                 620                 


Glu Asp Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly 
625                 630                 635                 640 


Thr Asp Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys 
                645                 650                 655     


Gln Glu Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser Ser Gly Arg 
            660                 665                 670         


Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
        675                 680         


<210>  2
<211>  682
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  2

Met Ala Asp Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala 
1               5                   10                  15      


Thr Ala Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro 
            20                  25                  30          


Ser Arg Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp 
        35                  40                  45              


Asp Glu Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr 
    50                  55                  60                  


Arg Asp Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His 
65                  70                  75                  80  


Ser Cys Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser 
                85                  90                  95      


Asp Trp Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln 
            100                 105                 110         


His Leu Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu 
        115                 120                 125             


Pro Glu Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln 
    130                 135                 140                 


Ile Val Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys 
145                 150                 155                 160 


Asp Ile Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys 
                165                 170                 175     


Lys Ile Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile 
            180                 185                 190         


Pro Asp Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp 
        195                 200                 205             


Phe Pro Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe 
    210                 215                 220                 


Arg Lys Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro 
225                 230                 235                 240 


Gly Gln Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp 
                245                 250                 255     


Lys Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu 
            260                 265                 270         


Glu Gln Val Ala Gly Ile Gln Arg Ile Ile Gln Cys Tyr Gly Ser Phe 
        275                 280                 285             


Ala Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala 
    290                 295                 300                 


Val Arg Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys 
305                 310                 315                 320 


Pro Ala Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe 
                325                 330                 335     


Gly Glu Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys 
            340                 345                 350         


Asp Glu Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg 
        355                 360                 365             


Pro Val Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile 
    370                 375                 380                 


Leu Ile Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu 
385                 390                 395                 400 


Leu Gly Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly 
                405                 410                 415     


Gly Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile 
            420                 425                 430         


Thr Glu Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu 
        435                 440                 445             


Leu Pro Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu 
    450                 455                 460                 


Arg Thr Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln 
465                 470                 475                 480 


Ala Ala Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys 
                485                 490                 495     


Met Glu Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser 
            500                 505                 510         


Ile Ala Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser 
        515                 520                 525             


Thr Gly Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys 
    530                 535                 540                 


Cys Trp Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp 
545                 550                 555                 560 


Gly Asn Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly 
                565                 570                 575     


Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser 
            580                 585                 590         


Cys Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu 
        595                 600                 605             


Glu Pro Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu 
    610                 615                 620                 


Glu Asp Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly 
625                 630                 635                 640 


Thr Asp Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys 
                645                 650                 655     


Gln Glu Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser Ser Gly Arg 
            660                 665                 670         


Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
        675                 680         


<210>  3
<211>  419
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  3

Met Asp Lys Lys Pro Leu Asp Val Leu Ile Ser Ala Thr Gly Leu Trp 
1               5                   10                  15      


Met Ser Arg Thr Gly Thr Leu His Lys Ile Lys His His Glu Val Ser 
            20                  25                  30          


Arg Ser Lys Ile Tyr Ile Glu Met Ala Cys Gly Asp His Leu Val Val 
        35                  40                  45              


Asn Asn Ser Arg Ser Cys Arg Thr Ala Arg Ala Phe Arg His His Lys 
    50                  55                  60                  


Tyr Arg Lys Thr Cys Lys Arg Cys Arg Val Ser Gly Glu Asp Ile Asn 
65                  70                  75                  80  


Asn Phe Leu Thr Arg Ser Thr Glu Ser Lys Asn Ser Val Lys Val Arg 
                85                  90                  95      


Val Val Ser Ala Pro Lys Val Lys Lys Ala Met Pro Lys Ser Val Ser 
            100                 105                 110         


Arg Ala Pro Lys Pro Leu Glu Asn Ser Val Gly Ala Lys Ala Ser Thr 
        115                 120                 125             


Asn Thr Ser Arg Ser Val Pro Ser Pro Ala Lys Ser Thr Pro Asn Ser 
    130                 135                 140                 


Ser Val Pro Ala Ser Ala Pro Ala Pro Ser Leu Thr Arg Ser Gln Leu 
145                 150                 155                 160 


Asp Arg Val Glu Ala Leu Leu Ser Pro Glu Asp Lys Ile Ser Leu Asn 
                165                 170                 175     


Met Ala Lys Pro Phe Arg Glu Leu Glu Pro Glu Leu Val Thr Arg Arg 
            180                 185                 190         


Lys Asn Asp Phe Gln Arg Leu Tyr Thr Asn Asp Arg Glu Asp Tyr Leu 
        195                 200                 205             


Gly Lys Leu Glu Arg Asp Ile Thr Lys Phe Phe Val Asp Arg Gly Phe 
    210                 215                 220                 


Leu Glu Ile Lys Ser Pro Ile Leu Ile Pro Ala Glu Tyr Val Glu Arg 
225                 230                 235                 240 


Met Gly Ile Asn Asn Asp Thr Glu Leu Ser Lys Gln Ile Phe Arg Val 
                245                 250                 255     


Asp Lys Asn Leu Cys Leu Arg Pro Met Met Ala Pro Thr Ile Phe Asn 
            260                 265                 270         


Tyr Ala Arg Lys Leu Asp Arg Ile Leu Pro Gly Pro Ile Lys Ile Phe 
        275                 280                 285             


Glu Val Gly Pro Cys Tyr Arg Lys Glu Ser Asp Gly Lys Glu His Leu 
    290                 295                 300                 


Glu Glu Phe Thr Met Val Asn Phe Phe Gln Met Gly Ser Gly Cys Thr 
305                 310                 315                 320 


Arg Glu Asn Leu Glu Ala Leu Ile Lys Glu Phe Leu Asp Tyr Leu Glu 
                325                 330                 335     


Ile Asp Phe Glu Ile Val Gly Asp Ser Cys Met Val Tyr Gly Asp Thr 
            340                 345                 350         


Leu Asp Ile Met His Gly Asp Leu Glu Leu Ser Ser Ala Val Val Gly 
        355                 360                 365             


Pro Val Ser Leu Asp Arg Glu Trp Gly Ile Asp Lys Pro Trp Ile Gly 
    370                 375                 380                 


Ala Gly Phe Gly Leu Glu Arg Leu Leu Lys Val Met His Gly Phe Lys 
385                 390                 395                 400 


Asn Ile Lys Arg Ala Ser Arg Ser Glu Ser Tyr Tyr Asn Gly Ile Ser 
                405                 410                 415     


Thr Asn Leu 
            


<210>  4
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  4

Met Asp Lys Lys Pro Leu Asn Thr Leu Ile Ser Ala Thr Gly Leu Trp 
1               5                   10                  15      


Met Ser Arg Thr Gly Thr Ile His Lys Ile Lys His His Glu Val Ser 
            20                  25                  30          


Arg Ser Lys Ile Tyr Ile Glu Met Ala Cys Gly Asp His Leu Val Val 
        35                  40                  45              


Asn Asn Ser Arg Ser Ser Arg Thr Ala Arg Ala Leu Arg His His Lys 
    50                  55                  60                  


Tyr Arg Lys Thr Cys Lys Arg Cys Arg Val Ser Asp Glu Asp Leu Asn 
65                  70                  75                  80  


Lys Phe Leu Thr Lys Ala Asn Glu Asp Gln Thr Ser Val Lys Val Lys 
                85                  90                  95      


Val Val Ser Ala Pro Thr Arg Thr Lys Lys Ala Met Pro Lys Ser Val 
            100                 105                 110         


Ala Arg Ala Pro Lys Pro Leu Glu Asn Thr Glu Ala Ala Gln Ala Gln 
        115                 120                 125             


Pro Ser Gly Ser Lys Phe Ser Pro Ala Ile Pro Val Ser Thr Gln Glu 
    130                 135                 140                 


Ser Val Ser Val Pro Ala Ser Val Ser Thr Ser Ile Ser Ser Ile Ser 
145                 150                 155                 160 


Thr Gly Ala Thr Ala Ser Ala Leu Val Lys Gly Asn Thr Asn Pro Ile 
                165                 170                 175     


Thr Ser Met Ser Ala Pro Val Gln Ala Ser Ala Pro Ala Leu Thr Lys 
            180                 185                 190         


Ser Gln Thr Asp Arg Leu Glu Val Leu Leu Asn Pro Lys Asp Glu Ile 
        195                 200                 205             


Ser Leu Asn Ser Gly Lys Pro Phe Arg Glu Leu Glu Ser Glu Leu Leu 
    210                 215                 220                 


Ser Arg Arg Lys Lys Asp Leu Gln Gln Ile Tyr Ala Glu Glu Arg Glu 
225                 230                 235                 240 


Asn Tyr Leu Gly Lys Leu Glu Arg Glu Ile Thr Arg Phe Phe Val Asp 
                245                 250                 255     


Arg Gly Phe Leu Glu Ile Lys Ser Pro Ile Leu Ile Pro Leu Glu Tyr 
            260                 265                 270         


Ile Glu Arg Met Gly Ile Asp Asn Asp Thr Glu Leu Ser Lys Gln Ile 
        275                 280                 285             


Phe Arg Val Asp Lys Asn Phe Cys Leu Arg Pro Met Met Ala Pro Asn 
    290                 295                 300                 


Leu Leu Asn Tyr Ala Arg Lys Leu Asp Arg Ala Leu Pro Asp Pro Ile 
305                 310                 315                 320 


Lys Ile Phe Glu Ile Gly Pro Cys Tyr Arg Lys Glu Ser Asp Gly Lys 
                325                 330                 335     


Glu His Leu Glu Glu Phe Thr Met Leu Asn Phe Phe Gln Met Gly Ser 
            340                 345                 350         


Gly Cys Thr Arg Glu Asn Leu Glu Ser Ile Ile Thr Asp Phe Leu Asn 
        355                 360                 365             


His Leu Gly Ile Asp Phe Lys Ile Val Gly Asp Ser Cys Met Val Tyr 
    370                 375                 380                 


Gly Asp Thr Leu Asp Val Met His Gly Asp Leu Glu Leu Ser Ser Ala 
385                 390                 395                 400 


Val Val Gly Pro Ile Pro Leu Asp Arg Glu Trp Gly Ile Asp Lys Pro 
                405                 410                 415     


Trp Ile Gly Ala Gly Phe Gly Leu Glu Arg Leu Leu Lys Val Lys His 
            420                 425                 430         


Asp Phe Lys Asn Ile Lys Arg Ala Ala Arg Ser Glu Ser Tyr Tyr Asn 
        435                 440                 445             


Gly Ile Ser Thr Asn Leu 
    450                 


<210>  5
<211>  721
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  5

Met Ala Asp Leu Asn Trp Lys Ile Glu Glu Gly Lys Leu Val Ile Trp 
1               5                   10                  15      


Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys 
            20                  25                  30          


Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys 
        35                  40                  45              


Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp 
    50                  55                  60                  


Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly 
65                  70                  75                  80  


Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr 
                85                  90                  95      


Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr 
            100                 105                 110         


Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu 
        115                 120                 125             


Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu 
    130                 135                 140                 


Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro 
145                 150                 155                 160 


Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys 
                165                 170                 175     


Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala 
            180                 185                 190         


Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys 
        195                 200                 205             


His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn 
    210                 215                 220                 


Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn 
225                 230                 235                 240 


Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe 
                245                 250                 255     


Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile 
            260                 265                 270         


Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn 
        275                 280                 285             


Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro 
    290                 295                 300                 


Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp 
305                 310                 315                 320 


Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met 
                325                 330                 335     


Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala 
            340                 345                 350         


Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys 
        355                 360                 365             


Asp Ala Gln Thr Asn Ser Ser Ser Gly Ser Thr Ser Glu Asn Leu Tyr 
    370                 375                 380                 


Phe Gln Gly Gly Ser Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala 
385                 390                 395                 400 


Glu Pro Ala Gln Ala Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro 
                405                 410                 415     


Lys Gln Arg Gly Met Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala 
            420                 425                 430         


Gly Ser Ile Pro Gly Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro 
        435                 440                 445             


Thr Ile Lys Ile Asn Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser 
    450                 455                 460                 


Leu Val Thr Lys Asp Pro Pro His Arg Pro His Pro His Glu Leu Val 
465                 470                 475                 480 


Gly Lys Asp Cys Arg Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp 
                485                 490                 495     


Arg Cys Ile His Ser Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys 
            500                 505                 510         


Arg Asp Leu Glu Gln Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn 
        515                 520                 525             


Pro Phe Gln Val Pro Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn 
    530                 535                 540                 


Ala Val Arg Leu Cys Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg 
545                 550                 555                 560 


Pro Leu Arg Leu Pro Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg 
                565                 570                 575     


Ala Pro Asn Thr Ala Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser 
            580                 585                 590         


Gly Ser Cys Leu Gly Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val 
        595                 600                 605             


Gln Lys Glu Asp Ile Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala 
    610                 615                 620                 


Arg Gly Ser Phe Ser Gln Ala Asp Val His Arg Gln Val Ala Ile Val 
625                 630                 635                 640 


Phe Arg Thr Pro Pro Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg 
                645                 650                 655     


Val Ser Met Gln Leu Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro 
            660                 665                 670         


Met Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu 
        675                 680                 685             


Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys 
    690                 695                 700                 


Ser Pro Phe Ser Gly Pro Thr Asp Ser Gly Gly His His His His His 
705                 710                 715                 720 


His 
    


<210>  6
<211>  72
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  6

Gly Gly Gly Ala Ala Cys Cys Thr Gly Ala Thr Cys Ala Thr Gly Thr 
1               5                   10                  15      


Ala Gly Ala Thr Cys Gly Ala Ala Thr Gly Gly Ala Cys Thr Cys Thr 
            20                  25                  30          


Ala Ala Ala Thr Cys Cys Gly Thr Thr Cys Ala Gly Cys Cys Gly Gly 
        35                  40                  45              


Gly Thr Thr Ala Gly Ala Thr Thr Cys Cys Cys Gly Gly Gly Gly Thr 
    50                  55                  60                  


Thr Thr Cys Cys Gly Cys Cys Ala 
65                  70          


