                         SEQUENCE LISTING

<110>  CRISPR THERAPEUTICS AG
<110>  Max-Planck-Gesellschaft zur Fvrderung der Wissenschaften e.V.
<110>  Helmholtz-Zentrum f|r Infektionsforschung GmbH
 
<120>  NOVEL FAMILY OF RNA-PROGRAMMABLE ENDONUCLEASES  AND THEIR USES IN
        GENOME EDITING AND OTHER APPLICATIONS

<130>  0116339-00006

<160>  171   

<170>  PatentIn version 3.5

<210>  1
<211>  3903
<212>  DNA
<213>  F. novicida U112

<400>  1
atgtcaattt atcaagaatt tgttaataaa tatagtttaa gtaaaactct aagatttgag       60

ttaatcccac agggtaaaac acttgaaaac ataaaagcaa gaggtttgat tttagatgat      120

gagaaaagag ctaaagacta caaaaaggct aaacaaataa ttgataaata tcatcagttt      180

tttatagagg agatattaag ttcggtttgt attagcgaag atttattaca aaactattct      240

gatgtttatt ttaaacttaa aaagagtgat gatgataatc tacaaaaaga ttttaaaagt      300

gcaaaagata cgataaagaa acaaatatct gaatatataa aggactcaga gaaatttaag      360

aatttgttta atcaaaacct tatcgatgct aaaaaagggc aagagtcaga tttaattcta      420

tggctaaagc aatctaagga taatggtata gaactattta aagccaatag tgatatcaca      480

gatatagatg aggcgttaga aataatcaaa tcttttaaag gttggacaac ttattttaag      540

ggttttcatg aaaatagaaa aaatgtttat agtagcaatg atattcctac atctattatt      600

tataggatag tagatgataa tttgcctaaa tttctagaaa ataaagctaa gtatgagagt      660

ttaaaagaca aagctccaga agctataaac tatgaacaaa ttaaaaaaga tttggcagaa      720

gagctaacct ttgatattga ctacaaaaca tctgaagtta atcaaagagt tttttcactt      780

gatgaagttt ttgagatagc aaactttaat aattatctaa atcaaagtgg tattactaaa      840

tttaatacta ttattggtgg taaatttgta aatggtgaaa atacaaagag aaaaggtata      900

aatgaatata taaatctata ctcacagcaa ataaatgata aaacactcaa aaaatataaa      960

atgagtgttt tatttaagca aattttaagt gatacagaat ctaaatcttt tgtaattgat     1020

aagttagaag atgatagtga tgtagttaca acgatgcaaa gtttttatga gcaaatagca     1080

gcttttaaaa cagtagaaga aaaatctatt aaagaaacac tatctttatt atttgatgat     1140

ttaaaagctc aaaaacttga tttgagtaaa atttatttta aaaatgataa atctcttact     1200

gatctatcac aacaagtttt tgatgattat agtgttattg gtacagcggt actagaatat     1260

ataactcaac aaatagcacc taaaaatctt gataacccta gtaagaaaga gcaagaatta     1320

atagccaaaa aaactgaaaa agcaaaatac ttatctctag aaactataaa gcttgcctta     1380

gaagaattta ataagcatag agatatagat aaacagtgta ggtttgaaga aatacttgca     1440

aactttgcgg ctattccgat gatatttgat gaaatagctc aaaacaaaga caatttggca     1500

cagatatcta tcaaatatca aaatcaaggt aaaaaagacc tacttcaagc tagtgcggaa     1560

gatgatgtta aagctatcaa ggatctttta gatcaaacta ataatctctt acataaacta     1620

aaaatatttc atattagtca gtcagaagat aaggcaaata ttttagacaa ggatgagcat     1680

ttttatctag tatttgagga gtgctacttt gagctagcga atatagtgcc tctttataac     1740

aaaattagaa actatataac tcaaaagcca tatagtgatg agaaatttaa gctcaatttt     1800

gagaactcga ctttggctaa tggttgggat aaaaataaag agcctgacaa tacggcaatt     1860

ttatttatca aagatgataa atattatctg ggtgtgatga ataagaaaaa taacaaaata     1920

tttgatgata aagctatcaa agaaaataaa ggcgagggtt ataaaaaaat tgtttataaa     1980

cttttacctg gcgcaaataa aatgttacct aaggttttct tttctgctaa atctataaaa     2040

ttttataatc ctagtgaaga tatacttaga ataagaaatc attccacaca tacaaaaaat     2100

ggtagtcctc aaaaaggata tgaaaaattt gagtttaata ttgaagattg ccgaaaattt     2160

atagattttt ataaacagtc tataagtaag catccggagt ggaaagattt tggatttaga     2220

ttttctgata ctcaaagata taattctata gatgaatttt atagagaagt tgaaaatcaa     2280

ggctacaaac taacttttga aaatatatca gagagctata ttgatagcgt agttaatcag     2340

ggtaaattgt acctattcca aatctataat aaagattttt cagcttatag caaagggcga     2400

ccaaatctac atactttata ttggaaagcg ctgtttgatg agagaaatct tcaagatgtg     2460

gtttataagc taaatggtga ggcagagctt ttttatcgta aacaatcaat acctaaaaaa     2520

atcactcacc cagctaaaga ggcaatagct aataaaaaca aagataatcc taaaaaagag     2580

agtgtttttg aatatgattt aatcaaagat aaacgcttta ctgaagataa gtttttcttt     2640

cactgtccta ttacaatcaa ttttaaatct agtggagcta ataagtttaa tgatgaaatc     2700

aatttattgc taaaagaaaa agcaaatgat gttcatatat taagtataga tagaggtgaa     2760

agacatttag cttactatac tttggtagat ggtaaaggca atatcatcaa acaagatact     2820

ttcaacatca ttggtaatga tagaatgaaa acaaactacc atgataagct tgctgcaata     2880

gagaaagata gggattcagc taggaaagac tggaaaaaga taaataacat caaagagatg     2940

aaagagggct atctatctca ggtagttcat gaaatagcta agctagttat agagtataat     3000

gctattgtgg tttttgagga tttaaatttt ggatttaaaa gagggcgttt caaggtagag     3060

aagcaggtct atcaaaagtt agaaaaaatg ctaattgaga aactaaacta tctagttttc     3120

aaagataatg agtttgataa aactggggga gtgcttagag cttatcagct aacagcacct     3180

tttgagactt ttaaaaagat gggtaaacaa acaggtatta tctactatgt accagctggt     3240

tttacttcaa aaatttgtcc tgtaactggt tttgtaaatc agttatatcc taagtatgaa     3300

agtgtcagca aatctcaaga gttctttagt aagtttgaca agatttgtta taaccttgat     3360

aagggctatt ttgagtttag ttttgattat aaaaactttg gtgacaaggc tgccaaaggc     3420

aagtggacta tagctagctt tgggagtaga ttgattaact ttagaaattc agataaaaat     3480

cataattggg atactcgaga agtttatcca actaaagagt tggagaaatt gctaaaagat     3540

tattctatcg aatatgggca tggcgaatgt atcaaagcag ctatttgcgg tgagagcgac     3600

aaaaagtttt ttgctaagct aactagtgtc ctaaatacta tcttacaaat gcgtaactca     3660

aaaacaggta ctgagttaga ttatctaatt tcaccagtag cagatgtaaa tggcaatttc     3720

tttgattcgc gacaggcgcc aaaaaatatg cctcaagatg ctgatgccaa tggtgcttat     3780

catattgggc taaaaggtct gatgctacta ggtaggatca aaaataatca agagggcaaa     3840

aaactcaatt tggttatcaa aaatgaagag tattttgagt tcgtgcagaa taggaataac     3900

taa                                                                   3903


<210>  2
<211>  1300
<212>  PRT
<213>  F. novicida U112

<400>  2

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  3
<211>  1253
<212>  PRT
<213>  Prevotella albensis M384

<400>  3

Met Asn Ile Lys Asn Phe Thr Gly Leu Tyr Pro Leu Ser Lys Thr Leu 
1               5                   10                  15      


Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Lys Glu Asn Ile Glu Lys 
            20                  25                  30          


Asn Gly Ile Leu Thr Lys Asp Glu Gln Arg Ala Lys Asp Tyr Leu Ile 
        35                  40                  45              


Val Lys Gly Phe Ile Asp Glu Tyr His Lys Gln Phe Ile Lys Asp Arg 
    50                  55                  60                  


Leu Trp Asp Phe Lys Leu Pro Leu Glu Ser Glu Gly Glu Lys Asn Ser 
65                  70                  75                  80  


Leu Glu Glu Tyr Gln Glu Leu Tyr Glu Leu Thr Lys Arg Asn Asp Ala 
                85                  90                  95      


Gln Glu Ala Asp Phe Thr Glu Ile Lys Asp Asn Leu Arg Ser Ser Ile 
            100                 105                 110         


Thr Glu Gln Leu Thr Lys Ser Gly Ser Ala Tyr Asp Arg Ile Phe Lys 
        115                 120                 125             


Lys Glu Phe Ile Arg Glu Asp Leu Val Asn Phe Leu Glu Asp Glu Lys 
    130                 135                 140                 


Asp Lys Asn Ile Val Lys Gln Phe Glu Asp Phe Thr Thr Tyr Phe Thr 
145                 150                 155                 160 


Gly Phe Tyr Glu Asn Arg Lys Asn Met Tyr Ser Ser Glu Glu Lys Ser 
                165                 170                 175     


Thr Ala Ile Ala Tyr Arg Leu Ile His Gln Asn Leu Pro Lys Phe Met 
            180                 185                 190         


Asp Asn Met Arg Ser Phe Ala Lys Ile Ala Asn Ser Ser Val Ser Glu 
        195                 200                 205             


His Phe Ser Asp Ile Tyr Glu Ser Trp Lys Glu Tyr Leu Asn Val Asn 
    210                 215                 220                 


Ser Ile Glu Glu Ile Phe Gln Leu Asp Tyr Phe Ser Glu Thr Leu Thr 
225                 230                 235                 240 


Gln Pro His Ile Glu Val Tyr Asn Tyr Ile Ile Gly Lys Lys Val Leu 
                245                 250                 255     


Glu Asp Gly Thr Glu Ile Lys Gly Ile Asn Glu Tyr Val Asn Leu Tyr 
            260                 265                 270         


Asn Gln Gln Gln Lys Asp Lys Ser Lys Arg Leu Pro Phe Leu Val Pro 
        275                 280                 285             


Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Lys Leu Ser Trp Ile Ala 
    290                 295                 300                 


Glu Glu Phe Asp Ser Asp Lys Lys Met Leu Ser Ala Ile Thr Glu Ser 
305                 310                 315                 320 


Tyr Asn His Leu His Asn Val Leu Met Gly Asn Glu Asn Glu Ser Leu 
                325                 330                 335     


Arg Asn Leu Leu Leu Asn Ile Lys Asp Tyr Asn Leu Glu Lys Ile Asn 
            340                 345                 350         


Ile Thr Asn Asp Leu Ser Leu Thr Glu Ile Ser Gln Asn Leu Phe Gly 
        355                 360                 365             


Arg Tyr Asp Val Phe Thr Asn Gly Ile Lys Asn Lys Leu Arg Val Leu 
    370                 375                 380                 


Thr Pro Arg Lys Lys Lys Glu Thr Asp Glu Asn Phe Glu Asp Arg Ile 
385                 390                 395                 400 


Asn Lys Ile Phe Lys Thr Gln Lys Ser Phe Ser Ile Ala Phe Leu Asn 
                405                 410                 415     


Lys Leu Pro Gln Pro Glu Met Glu Asp Gly Lys Pro Arg Asn Ile Glu 
            420                 425                 430         


Asp Tyr Phe Ile Thr Gln Gly Ala Ile Asn Thr Lys Ser Ile Gln Lys 
        435                 440                 445             


Glu Asp Ile Phe Ala Gln Ile Glu Asn Ala Tyr Glu Asp Ala Gln Val 
    450                 455                 460                 


Phe Leu Gln Ile Lys Asp Thr Asp Asn Lys Leu Ser Gln Asn Lys Thr 
465                 470                 475                 480 


Ala Val Glu Lys Ile Lys Thr Leu Leu Asp Ala Leu Lys Glu Leu Gln 
                485                 490                 495     


His Phe Ile Lys Pro Leu Leu Gly Ser Gly Glu Glu Asn Glu Lys Asp 
            500                 505                 510         


Glu Leu Phe Tyr Gly Ser Phe Leu Ala Ile Trp Asp Glu Leu Asp Thr 
        515                 520                 525             


Ile Thr Pro Leu Tyr Asn Lys Val Arg Asn Trp Leu Thr Arg Lys Pro 
    530                 535                 540                 


Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Asp Asn Ala Gln Leu Leu 
545                 550                 555                 560 


Gly Gly Trp Asp Val Asn Lys Glu His Asp Cys Ala Gly Ile Leu Leu 
                565                 570                 575     


Arg Lys Asn Asp Ser Tyr Tyr Leu Gly Ile Ile Asn Lys Lys Thr Asn 
            580                 585                 590         


His Ile Phe Asp Thr Asp Ile Thr Pro Ser Asp Gly Glu Cys Tyr Asp 
        595                 600                 605             


Lys Ile Asp Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys 
    610                 615                 620                 


Val Phe Phe Ser Lys Ser Arg Ile Lys Glu Phe Glu Pro Ser Glu Ala 
625                 630                 635                 640 


Ile Ile Asn Cys Tyr Lys Lys Gly Thr His Lys Lys Gly Lys Asn Phe 
                645                 650                 655     


Asn Leu Thr Asp Cys His Arg Leu Ile Asn Phe Phe Lys Thr Ser Ile 
            660                 665                 670         


Glu Lys His Glu Asp Trp Ser Lys Phe Gly Phe Lys Phe Ser Asp Thr 
        675                 680                 685             


Glu Thr Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu Val Glu Gln Gln 
    690                 695                 700                 


Gly Tyr Arg Leu Thr Ser His Pro Val Ser Ala Ser Tyr Ile His Ser 
705                 710                 715                 720 


Leu Val Lys Glu Gly Lys Leu Tyr Leu Phe Gln Ile Trp Asn Lys Asp 
                725                 730                 735     


Phe Ser Gln Phe Ser Lys Gly Thr Pro Asn Leu His Thr Leu Tyr Trp 
            740                 745                 750         


Lys Met Leu Phe Asp Lys Arg Asn Leu Ser Asp Val Val Tyr Lys Leu 
        755                 760                 765             


Asn Gly Gln Ala Glu Val Phe Tyr Arg Lys Ser Ser Ile Glu His Gln 
    770                 775                 780                 


Asn Arg Ile Ile His Pro Ala Gln His Pro Ile Thr Asn Lys Asn Glu 
785                 790                 795                 800 


Leu Asn Lys Lys His Thr Ser Thr Phe Lys Tyr Asp Ile Ile Lys Asp 
                805                 810                 815     


Arg Arg Tyr Thr Val Asp Lys Phe Gln Phe His Val Pro Ile Thr Ile 
            820                 825                 830         


Asn Phe Lys Ala Thr Gly Gln Asn Asn Ile Asn Pro Ile Val Gln Glu 
        835                 840                 845             


Val Ile Arg Gln Asn Gly Ile Thr His Ile Ile Gly Ile Asp Arg Gly 
    850                 855                 860                 


Glu Arg His Leu Leu Tyr Leu Ser Leu Ile Asp Leu Lys Gly Asn Ile 
865                 870                 875                 880 


Ile Lys Gln Met Thr Leu Asn Glu Ile Ile Asn Glu Tyr Lys Gly Val 
                885                 890                 895     


Thr Tyr Lys Thr Asn Tyr His Asn Leu Leu Glu Lys Arg Glu Lys Glu 
            900                 905                 910         


Arg Thr Glu Ala Arg His Ser Trp Ser Ser Ile Glu Ser Ile Lys Glu 
        915                 920                 925             


Leu Lys Asp Gly Tyr Met Ser Gln Val Ile His Lys Ile Thr Asp Met 
    930                 935                 940                 


Met Val Lys Tyr Asn Ala Ile Val Val Leu Glu Asp Leu Asn Gly Gly 
945                 950                 955                 960 


Phe Met Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe 
                965                 970                 975     


Glu Lys Lys Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Lys Leu 
            980                 985                 990         


Asp Ala Asn Glu Val Gly Gly Val  Leu Asn Ala Tyr Gln  Leu Thr Asn 
        995                 1000                 1005             


Lys Phe  Glu Ser Phe Lys Lys  Ile Gly Lys Gln Ser  Gly Phe Leu 
    1010                 1015                 1020             


Phe Tyr  Ile Pro Ala Trp Asn  Thr Ser Lys Ile Asp  Pro Ile Thr 
    1025                 1030                 1035             


Gly Phe  Val Asn Leu Phe Asn  Thr Arg Tyr Glu Ser  Ile Lys Glu 
    1040                 1045                 1050             


Thr Lys  Val Phe Trp Ser Lys  Phe Asp Ile Ile Arg  Tyr Asn Lys 
    1055                 1060                 1065             


Glu Lys  Asn Trp Phe Glu Phe  Val Phe Asp Tyr Asn  Thr Phe Thr 
    1070                 1075                 1080             


Thr Lys  Ala Glu Gly Thr Arg  Thr Lys Trp Thr Leu  Cys Thr His 
    1085                 1090                 1095             


Gly Thr  Arg Ile Gln Thr Phe  Arg Asn Pro Glu Lys  Asn Ala Gln 
    1100                 1105                 1110             


Trp Asp  Asn Lys Glu Ile Asn  Leu Thr Glu Ser Phe  Lys Ala Leu 
    1115                 1120                 1125             


Phe Glu  Lys Tyr Lys Ile Asp  Ile Thr Ser Asn Leu  Lys Glu Ser 
    1130                 1135                 1140             


Ile Met  Gln Glu Thr Glu Lys  Lys Phe Phe Gln Glu  Leu His Asn 
    1145                 1150                 1155             


Leu Leu  His Leu Thr Leu Gln  Met Arg Asn Ser Val  Thr Gly Thr 
    1160                 1165                 1170             


Asp Ile  Asp Tyr Leu Ile Ser  Pro Val Ala Asp Glu  Asp Gly Asn 
    1175                 1180                 1185             


Phe Tyr  Asp Ser Arg Ile Asn  Gly Lys Asn Phe Pro  Glu Asn Ala 
    1190                 1195                 1200             


Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg Lys Gly  Leu Met Leu 
    1205                 1210                 1215             


Ile Arg  Gln Ile Lys Gln Ala  Asp Pro Gln Lys Lys  Phe Lys Phe 
    1220                 1225                 1230             


Glu Thr  Ile Thr Asn Lys Asp  Trp Leu Lys Phe Ala  Gln Asp Lys 
    1235                 1240                 1245             


Pro Tyr  Leu Lys Asp 
    1250             


<210>  4
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp. BV3L6

<400>  4

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  5
<211>  1282
<212>  PRT
<213>  Eubacterium eligens CAG:72

<400>  5

Met Asn Gly Asn Arg Ser Ile Val Tyr Arg Glu Phe Val Gly Val Thr 
1               5                   10                  15      


Pro Val Ala Lys Thr Leu Arg Asn Glu Leu Arg Pro Val Gly His Thr 
            20                  25                  30          


Gln Glu His Ile Ile Gln Asn Gly Leu Ile Gln Glu Asp Glu Leu Arg 
        35                  40                  45              


Gln Glu Lys Ser Thr Glu Leu Lys Asn Ile Met Asp Asp Tyr Tyr Arg 
    50                  55                  60                  


Glu Tyr Ile Asp Lys Ser Leu Ser Gly Leu Thr Asp Leu Asp Phe Thr 
65                  70                  75                  80  


Leu Leu Phe Glu Leu Met Asn Ser Val Gln Ser Ser Leu Ser Lys Asp 
                85                  90                  95      


Asn Lys Lys Ala Leu Glu Lys Glu His Asn Lys Met Arg Glu Gln Ile 
            100                 105                 110         


Cys Thr His Leu Gln Ser Asp Ser Asp Tyr Lys Asn Met Phe Asn Ala 
        115                 120                 125             


Lys Leu Phe Lys Glu Ile Leu Pro Asp Phe Ile Lys Asn Tyr Asn Gln 
    130                 135                 140                 


Tyr Asp Val Lys Asp Lys Ala Gly Lys Leu Glu Thr Leu Ala Leu Phe 
145                 150                 155                 160 


Asn Gly Phe Ser Thr Tyr Phe Thr Asp Phe Phe Glu Lys Arg Lys Asn 
                165                 170                 175     


Val Phe Thr Lys Glu Ala Val Ser Thr Ser Ile Ala Tyr Arg Ile Val 
            180                 185                 190         


His Glu Asn Ser Leu Ile Phe Leu Ala Asn Met Thr Ser Tyr Lys Lys 
        195                 200                 205             


Ile Ser Glu Lys Ala Leu Asp Glu Ile Glu Val Ile Glu Lys Asn Asn 
    210                 215                 220                 


Gln Asp Lys Met Gly Asp Trp Glu Leu Asn Gln Ile Phe Asn Pro Asp 
225                 230                 235                 240 


Phe Tyr Asn Met Val Leu Ile Gln Ser Gly Ile Asp Phe Tyr Asn Glu 
                245                 250                 255     


Ile Cys Gly Val Val Asn Ala His Met Asn Leu Tyr Cys Gln Gln Thr 
            260                 265                 270         


Lys Asn Asn Tyr Asn Leu Phe Lys Met Arg Lys Leu His Lys Gln Ile 
        275                 280                 285             


Leu Ala Tyr Thr Ser Thr Ser Phe Glu Val Pro Lys Met Phe Glu Asp 
    290                 295                 300                 


Asp Met Ser Val Tyr Asn Ala Val Asn Ala Phe Ile Asp Glu Thr Glu 
305                 310                 315                 320 


Lys Gly Asn Ile Ile Gly Lys Leu Lys Asp Ile Val Asn Lys Tyr Asp 
                325                 330                 335     


Glu Leu Asp Glu Lys Arg Ile Tyr Ile Ser Lys Asp Phe Tyr Glu Thr 
            340                 345                 350         


Leu Ser Cys Phe Met Ser Gly Asn Trp Asn Leu Ile Thr Gly Cys Val 
        355                 360                 365             


Glu Asn Phe Tyr Asp Glu Asn Ile His Ala Lys Gly Lys Ser Lys Glu 
    370                 375                 380                 


Glu Lys Val Lys Lys Ala Val Lys Glu Asp Lys Tyr Lys Ser Ile Asn 
385                 390                 395                 400 


Asp Val Asn Asp Leu Val Glu Lys Tyr Ile Asp Glu Lys Glu Arg Asn 
                405                 410                 415     


Glu Phe Lys Asn Ser Asn Ala Lys Gln Tyr Ile Arg Glu Ile Ser Asn 
            420                 425                 430         


Ile Ile Thr Asp Thr Glu Thr Ala His Leu Glu Tyr Asp Glu His Ile 
        435                 440                 445             


Ser Leu Ile Glu Ser Glu Glu Lys Ala Asp Glu Ile Lys Lys Arg Leu 
    450                 455                 460                 


Asp Met Tyr Met Asn Met Tyr His Trp Val Lys Ala Phe Ile Val Asp 
465                 470                 475                 480 


Glu Val Leu Asp Arg Asp Glu Met Phe Tyr Ser Asp Ile Asp Asp Ile 
                485                 490                 495     


Tyr Asn Ile Leu Glu Asn Ile Val Pro Leu Tyr Asn Arg Val Arg Asn 
            500                 505                 510         


Tyr Val Thr Gln Lys Pro Tyr Thr Ser Lys Lys Ile Lys Leu Asn Phe 
        515                 520                 525             


Gln Ser Pro Thr Leu Ala Asn Gly Trp Ser Gln Ser Lys Glu Phe Asp 
    530                 535                 540                 


Asn Asn Ala Ile Ile Leu Ile Arg Asp Asn Lys Tyr Tyr Leu Ala Ile 
545                 550                 555                 560 


Phe Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Ile Gln Gly Asn Ser 
                565                 570                 575     


Asp Lys Lys Asn Asp Asn Asp Tyr Lys Lys Met Val Tyr Asn Leu Leu 
            580                 585                 590         


Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Leu Ser Lys Lys Gly 
        595                 600                 605             


Ile Glu Thr Phe Lys Pro Ser Asp Tyr Ile Ile Ser Gly Tyr Asn Ala 
    610                 615                 620                 


His Lys His Ile Lys Thr Ser Glu Asn Phe Asp Ile Ser Phe Cys Arg 
625                 630                 635                 640 


Asp Leu Ile Asp Tyr Phe Lys Asn Ser Ile Glu Lys His Ala Glu Trp 
                645                 650                 655     


Arg Lys Tyr Glu Phe Lys Phe Ser Ala Thr Asp Ser Tyr Asn Asp Ile 
            660                 665                 670         


Ser Glu Phe Tyr Arg Glu Val Glu Met Gln Gly Tyr Arg Ile Asp Trp 
        675                 680                 685             


Thr Tyr Ile Ser Glu Ala Asp Ile Asn Lys Leu Asp Glu Glu Gly Lys 
    690                 695                 700                 


Ile Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Glu Asn Ser Thr 
705                 710                 715                 720 


Gly Lys Glu Asn Leu His Thr Met Tyr Phe Lys Asn Ile Phe Ser Glu 
                725                 730                 735     


Glu Asn Leu Lys Asn Ile Val Ile Lys Leu Asn Gly Gln Ala Glu Leu 
            740                 745                 750         


Phe Tyr Arg Lys Ala Ser Val Lys Asn Pro Val Lys His Lys Lys Asp 
        755                 760                 765             


Ser Val Leu Val Asn Lys Thr Tyr Lys Asn Gln Leu Asp Asn Gly Asp 
    770                 775                 780                 


Val Val Arg Ile Pro Ile Pro Asp Asp Ile Tyr Asn Glu Ile Tyr Lys 
785                 790                 795                 800 


Met Tyr Asn Gly Tyr Ile Lys Glu Ser Asp Leu Ser Glu Ala Ala Lys 
                805                 810                 815     


Glu Tyr Leu Asp Lys Val Glu Val Arg Thr Ala Gln Lys Asp Ile Val 
            820                 825                 830         


Lys Asp Tyr Arg Tyr Thr Val Asp Lys Tyr Phe Ile His Thr Pro Ile 
        835                 840                 845             


Thr Ile Asn Tyr Lys Val Thr Ala Arg Asn Asn Val Asn Asp Met Ala 
    850                 855                 860                 


Val Lys Tyr Ile Ala Gln Asn Asp Asp Ile His Val Ile Gly Ile Asp 
865                 870                 875                 880 


Arg Gly Glu Arg Asn Leu Ile Tyr Ile Ser Val Ile Asp Ser His Gly 
                885                 890                 895     


Asn Ile Val Lys Gln Lys Ser Tyr Asn Ile Leu Asn Asn Tyr Asp Tyr 
            900                 905                 910         


Lys Lys Lys Leu Val Glu Lys Glu Lys Thr Arg Glu Tyr Ala Arg Lys 
        915                 920                 925             


Asn Trp Lys Ser Ile Gly Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile 
    930                 935                 940                 


Ser Gly Val Val His Glu Ile Ala Met Leu Met Val Glu Tyr Asn Ala 
945                 950                 955                 960 


Ile Ile Ala Met Glu Asp Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe 
                965                 970                 975     


Lys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Ser Met Leu Ile Asn 
            980                 985                 990         


Lys Leu Asn Tyr Phe Ala Ser Lys  Gly Lys Ser Val Asp  Glu Pro Gly 
        995                 1000                 1005             


Gly Leu  Leu Lys Gly Tyr Gln  Leu Thr Tyr Val Pro  Asp Asn Ile 
    1010                 1015                 1020             


Lys Asn  Leu Gly Lys Gln Cys  Gly Val Ile Phe Tyr  Val Pro Ala 
    1025                 1030                 1035             


Ala Phe  Thr Ser Lys Ile Asp  Pro Ser Thr Gly Phe  Ile Ser Ala 
    1040                 1045                 1050             


Phe Asn  Phe Lys Ser Ile Ser  Thr Asn Ala Ser Arg  Lys Gln Phe 
    1055                 1060                 1065             


Phe Met  Gln Phe Asp Glu Ile  Arg Tyr Cys Ala Glu  Lys Asp Met 
    1070                 1075                 1080             


Phe Ser  Phe Gly Phe Asp Tyr  Asn Asn Phe Asp Thr  Tyr Asn Ile 
    1085                 1090                 1095             


Thr Met  Gly Lys Thr Gln Trp  Thr Val Tyr Thr Asn  Gly Glu Arg 
    1100                 1105                 1110             


Leu Gln  Ser Glu Phe Asn Asn  Ala Arg Arg Thr Gly  Lys Thr Lys 
    1115                 1120                 1125             


Ser Ile  Asn Leu Thr Glu Thr  Ile Lys Leu Leu Leu  Glu Asp Asn 
    1130                 1135                 1140             


Glu Ile  Asn Tyr Ala Asp Gly  His Asp Val Arg Ile  Asp Met Glu 
    1145                 1150                 1155             


Lys Met  Tyr Glu Asp Lys Asn  Ser Glu Phe Phe Ala  Gln Leu Leu 
    1160                 1165                 1170             


Ser Leu  Tyr Lys Leu Thr Val  Gln Met Arg Asn Ser  Tyr Thr Glu 
    1175                 1180                 1185             


Ala Glu  Glu Gln Glu Lys Gly  Ile Ser Tyr Asp Lys  Ile Ile Ser 
    1190                 1195                 1200             


Pro Val  Ile Asn Asp Glu Gly  Glu Phe Phe Asp Ser  Asp Asn Tyr 
    1205                 1210                 1215             


Lys Glu  Ser Asp Asp Lys Glu  Cys Lys Met Pro Lys  Asp Ala Asp 
    1220                 1225                 1230             


Ala Asn  Gly Ala Tyr Cys Ile  Ala Leu Lys Gly Leu  Tyr Glu Val 
    1235                 1240                 1245             


Leu Lys  Ile Lys Ser Glu Trp  Thr Glu Asp Gly Phe  Asp Arg Asn 
    1250                 1255                 1260             


Cys Leu  Lys Leu Pro His Ala  Glu Trp Leu Asp Phe  Ile Gln Asn 
    1265                 1270                 1275             


Lys Arg  Tyr Glu 
    1280         


<210>  6
<211>  1231
<212>  PRT
<213>  Butyrivibrio fibrisolvens

<400>  6

Met Tyr Tyr Glu Ser Leu Thr Lys Leu Tyr Pro Ile Lys Lys Thr Ile 
1               5                   10                  15      


Arg Asn Glu Leu Val Pro Ile Gly Lys Thr Leu Glu Asn Ile Lys Lys 
            20                  25                  30          


Asn Asn Ile Leu Glu Ala Asp Glu Asp Arg Lys Ile Ala Tyr Ile Arg 
        35                  40                  45              


Val Lys Ala Ile Met Asp Asp Tyr His Lys Arg Leu Ile Asn Glu Ala 
    50                  55                  60                  


Leu Ser Gly Phe Ala Leu Ile Asp Leu Asp Lys Ala Ala Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Ser Ala Asp Asp Ile Glu Ser Phe Ser Arg Phe 
                85                  90                  95      


Gln Asp Lys Leu Arg Lys Ala Ile Ala Lys Arg Leu Arg Glu His Glu 
            100                 105                 110         


Asn Phe Gly Lys Ile Gly Asn Lys Asp Ile Ile Pro Leu Leu Gln Lys 
        115                 120                 125             


Leu Ser Glu Asn Glu Asp Asp Tyr Asn Ala Leu Glu Ser Phe Lys Asn 
    130                 135                 140                 


Phe Tyr Thr Tyr Phe Glu Ser Tyr Asn Asp Val Arg Leu Asn Leu Tyr 
145                 150                 155                 160 


Ser Asp Lys Glu Lys Ser Ser Thr Val Ala Tyr Arg Leu Ile Asn Glu 
                165                 170                 175     


Asn Leu Pro Arg Phe Leu Asp Asn Ile Arg Ala Tyr Asp Ala Val Gln 
            180                 185                 190         


Lys Ala Gly Ile Thr Ser Glu Glu Leu Ser Ser Glu Ala Gln Asp Gly 
        195                 200                 205             


Leu Phe Leu Val Asn Thr Phe Asn Asn Val Leu Ile Gln Asp Gly Ile 
    210                 215                 220                 


Asn Thr Tyr Asn Glu Asp Ile Gly Lys Leu Asn Val Ala Ile Asn Leu 
225                 230                 235                 240 


Tyr Asn Gln Lys Asn Ala Ser Val Gln Gly Phe Arg Lys Val Pro Lys 
                245                 250                 255     


Met Lys Val Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Glu Ser Phe 
            260                 265                 270         


Ile Asp Glu Phe Glu Ser Asp Thr Glu Leu Leu Asp Ser Leu Glu Ser 
        275                 280                 285             


His Tyr Ala Asn Leu Ala Lys Tyr Phe Gly Ser Asn Lys Val Gln Leu 
    290                 295                 300                 


Leu Phe Thr Ala Leu Arg Glu Ser Lys Gly Val Asn Val Tyr Val Lys 
305                 310                 315                 320 


Asn Asp Ile Ala Lys Thr Ser Phe Ser Asn Val Val Phe Gly Ser Trp 
                325                 330                 335     


Ser Arg Ile Asp Glu Leu Ile Asn Gly Glu Tyr Asp Asp Asn Asn Asn 
            340                 345                 350         


Arg Lys Lys Asp Glu Lys Tyr Tyr Asp Lys Arg Gln Lys Glu Leu Lys 
        355                 360                 365             


Lys Asn Lys Ser Tyr Thr Ile Glu Lys Ile Ile Thr Leu Ser Thr Glu 
    370                 375                 380                 


Asp Val Asp Val Ile Gly Lys Tyr Ile Glu Lys Leu Glu Ser Asp Ile 
385                 390                 395                 400 


Asp Asp Ile Arg Phe Lys Gly Lys Asn Phe Tyr Glu Ala Val Leu Cys 
                405                 410                 415     


Gly His Asp Arg Ser Lys Lys Leu Ser Lys Asn Lys Gly Ala Val Glu 
            420                 425                 430         


Ala Ile Lys Gly Tyr Leu Asp Ser Val Lys Asp Phe Glu Arg Asp Leu 
        435                 440                 445             


Lys Leu Ile Asn Gly Ser Gly Gln Glu Leu Glu Lys Asn Leu Val Val 
    450                 455                 460                 


Tyr Gly Glu Gln Glu Ala Val Leu Ser Glu Leu Ser Gly Ile Asp Ser 
465                 470                 475                 480 


Leu Tyr Asn Met Thr Arg Asn Tyr Leu Thr Lys Lys Pro Phe Ser Thr 
                485                 490                 495     


Glu Lys Ile Lys Leu Asn Phe Asn Lys Pro Thr Phe Leu Asp Gly Trp 
            500                 505                 510         


Asp Tyr Gly Asn Glu Glu Ala Tyr Leu Gly Phe Phe Met Ile Lys Glu 
        515                 520                 525             


Gly Asn Tyr Phe Leu Ala Val Met Asp Ala Asn Trp Asn Lys Glu Phe 
    530                 535                 540                 


Arg Asn Ile Pro Ser Val Asp Lys Ser Asp Cys Tyr Lys Lys Val Ile 
545                 550                 555                 560 


Tyr Lys Gln Ile Ser Ser Pro Glu Lys Ser Ile Gln Asn Leu Met Val 
                565                 570                 575     


Ile Asp Gly Lys Thr Val Lys Lys Asn Gly Arg Lys Glu Lys Glu Gly 
            580                 585                 590         


Ile His Ser Gly Glu Asn Leu Ile Leu Glu Glu Leu Lys Asn Thr Tyr 
        595                 600                 605             


Leu Pro Lys Lys Ile Asn Asp Ile Arg Lys Arg Arg Ser Tyr Leu Asn 
    610                 615                 620                 


Gly Asp Thr Phe Ser Lys Lys Asp Leu Thr Glu Phe Ile Gly Tyr Tyr 
625                 630                 635                 640 


Lys Gln Arg Val Ile Glu Tyr Tyr Asn Gly Tyr Ser Phe Tyr Phe Lys 
                645                 650                 655     


Ser Asp Asp Asp Tyr Ala Ser Phe Lys Glu Phe Gln Glu Asp Val Gly 
            660                 665                 670         


Arg Gln Ala Tyr Gln Ile Ser Tyr Val Asp Val Pro Val Ser Phe Val 
        675                 680                 685             


Asp Asp Leu Ile Asn Ser Gly Lys Leu Tyr Leu Phe Arg Val Tyr Asn 
    690                 695                 700                 


Lys Asp Phe Ser Glu Tyr Ser Lys Gly Arg Leu Asn Leu His Thr Leu 
705                 710                 715                 720 


Tyr Phe Lys Met Leu Phe Asp Glu Arg Asn Leu Lys Asn Val Val Tyr 
                725                 730                 735     


Lys Leu Asn Gly Gln Ala Glu Val Phe Tyr Arg Pro Ser Ser Ile Lys 
            740                 745                 750         


Lys Glu Glu Leu Ile Val His Arg Ala Gly Glu Glu Ile Lys Asn Lys 
        755                 760                 765             


Asn Pro Lys Arg Ala Ala Gln Lys Pro Thr Arg Arg Leu Asp Tyr Asp 
    770                 775                 780                 


Ile Val Lys Asp Arg Arg Tyr Ser Gln Asp Lys Phe Met Leu His Thr 
785                 790                 795                 800 


Ser Ile Ile Met Asn Phe Gly Ala Glu Glu Asn Val Ser Phe Asn Asp 
                805                 810                 815     


Ile Val Asn Gly Val Leu Arg Asn Glu Asp Lys Val Asn Val Ile Gly 
            820                 825                 830         


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Val Val Val Ile Asp Pro 
        835                 840                 845             


Glu Gly Lys Ile Leu Glu Gln Arg Ser Leu Asn Cys Ile Thr Asp Ser 
    850                 855                 860                 


Asn Leu Asp Ile Glu Thr Asp Tyr His Arg Leu Leu Asp Glu Lys Glu 
865                 870                 875                 880 


Ser Asp Arg Lys Ile Ala Arg Arg Asp Trp Thr Thr Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Leu Ser Gln Val Val His Ile Val Ala 
            900                 905                 910         


Glu Leu Val Leu Lys Tyr Asn Ala Ile Ile Cys Leu Glu Asp Leu Asn 
        915                 920                 925             


Phe Gly Phe Lys Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Met Asp 
945                 950                 955                 960 


Lys Ser Arg Glu Gln Leu Ser Pro Glu Lys Ile Ser Gly Ala Leu Asn 
                965                 970                 975     


Ala Leu Gln Leu Thr Pro Asp Phe Lys Ser Phe Lys Val Leu Gly Lys 
            980                 985                 990         


Gln Thr Gly Ile Ile Tyr Tyr Val  Pro Ala Tyr Leu Thr  Ser Lys Ile 
        995                 1000                 1005             


Asp Pro  Met Thr Gly Phe Ala  Asn Leu Phe Tyr Val  Lys Tyr Glu 
    1010                 1015                 1020             


Asn Val  Asp Lys Ala Lys Glu  Phe Phe Ser Lys Phe  Asp Ser Ile 
    1025                 1030                 1035             


Lys Tyr  Asn Lys Asp Gly Lys  Asn Trp Asn Thr Lys  Gly Tyr Phe 
    1040                 1045                 1050             


Glu Phe  Ala Phe Asp Tyr Lys  Lys Phe Thr Asp Arg  Ala Tyr Gly 
    1055                 1060                 1065             


Arg Val  Ser Glu Trp Thr Val  Cys Thr Val Gly Glu  Arg Ile Ile 
    1070                 1075                 1080             


Lys Phe  Lys Asn Lys Glu Lys  Asn Asn Ser Tyr Asp  Asp Lys Val 
    1085                 1090                 1095             


Ile Asp  Leu Thr Asn Ser Leu  Lys Glu Leu Phe Asp  Ser Tyr Lys 
    1100                 1105                 1110             


Val Thr  Tyr Glu Ser Glu Val  Asp Leu Lys Asp Ala  Ile Leu Ala 
    1115                 1120                 1125             


Ile Asp  Asp Pro Ala Phe Tyr  Arg Asp Leu Thr Arg  Arg Leu Gln 
    1130                 1135                 1140             


Gln Thr  Leu Gln Met Arg Asn  Ser Ser Cys Asp Gly  Ser Arg Asp 
    1145                 1150                 1155             


Tyr Ile  Ile Ser Pro Val Lys  Asn Ser Lys Gly Glu  Phe Phe Cys 
    1160                 1165                 1170             


Ser Asp  Asn Asn Asp Asp Thr  Thr Pro Asn Asp Ala  Asp Ala Asn 
    1175                 1180                 1185             


Gly Ala  Phe Asn Ile Ala Arg  Lys Gly Leu Trp Val  Leu Asn Glu 
    1190                 1195                 1200             


Ile Arg  Asn Ser Glu Glu Gly  Ser Lys Ile Asn Leu  Ala Met Ser 
    1205                 1210                 1215             


Asn Ala  Gln Trp Leu Glu Tyr  Ala Gln Asp Asn Thr  Ile 
    1220                 1225                 1230     


<210>  7
<211>  1250
<212>  PRT
<213>  Smithella sp. SCADC

<400>  7

Met Gln Thr Leu Phe Glu Asn Phe Thr Asn Gln Tyr Pro Val Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Lys Asp Phe Ile 
            20                  25                  30          


Glu Gln Lys Gly Leu Leu Lys Lys Asp Glu Asp Arg Ala Glu Lys Tyr 
        35                  40                  45              


Lys Lys Val Lys Asn Ile Ile Asp Glu Tyr His Lys Asp Phe Ile Glu 
    50                  55                  60                  


Lys Ser Leu Asn Gly Leu Lys Leu Asp Gly Leu Glu Glu Tyr Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Lys Gln Glu Lys Asp Asp Lys Asp Lys Lys Ala Phe Asp 
                85                  90                  95      


Lys Glu Lys Glu Asn Leu Arg Lys Gln Ile Ala Asn Ala Phe Arg Asn 
            100                 105                 110         


Asn Glu Lys Phe Lys Thr Leu Phe Ala Lys Glu Leu Ile Lys Asn Asp 
        115                 120                 125             


Leu Met Ser Phe Ala Cys Glu Glu Asp Lys Lys Asn Val Lys Glu Phe 
    130                 135                 140                 


Glu Ala Phe Thr Thr Tyr Phe Thr Gly Phe His Gln Asn Arg Ala Asn 
145                 150                 155                 160 


Met Tyr Val Ala Asp Glu Lys Arg Thr Ala Ile Ala Ser Arg Leu Ile 
                165                 170                 175     


His Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Lys Ile Phe Glu Lys 
            180                 185                 190         


Met Lys Lys Glu Ala Pro Glu Leu Leu Ser Pro Phe Asn Gln Thr Leu 
        195                 200                 205             


Lys Asp Met Lys Asp Val Ile Lys Gly Thr Thr Leu Glu Glu Ile Phe 
    210                 215                 220                 


Ser Leu Asp Tyr Phe Asn Lys Thr Leu Thr Gln Ser Gly Ile Asp Ile 
225                 230                 235                 240 


Tyr Asn Ser Val Ile Gly Gly Arg Thr Pro Glu Glu Gly Lys Thr Lys 
                245                 250                 255     


Ile Lys Gly Leu Asn Glu Tyr Ile Asn Thr Asp Phe Asn Gln Lys Gln 
            260                 265                 270         


Thr Asp Lys Lys Lys Arg Gln Pro Lys Phe Lys Gln Leu Tyr Lys Gln 
        275                 280                 285             


Ile Leu Ser Asp Arg Gln Ser Leu Ser Phe Ile Ala Glu Ala Phe Lys 
    290                 295                 300                 


Asn Asp Thr Glu Ile Leu Glu Ala Ile Glu Lys Phe Tyr Val Asn Glu 
305                 310                 315                 320 


Leu Leu His Phe Ser Asn Glu Gly Lys Ser Thr Asn Val Leu Asp Ala 
                325                 330                 335     


Ile Lys Asn Ala Val Ser Asn Leu Glu Ser Phe Asn Leu Thr Lys Ile 
            340                 345                 350         


Tyr Phe Arg Ser Gly Thr Ser Leu Thr Asp Val Ser Arg Lys Val Phe 
        355                 360                 365             


Gly Glu Trp Ser Ile Ile Asn Arg Ala Leu Asp Asn Tyr Tyr Ala Thr 
    370                 375                 380                 


Thr Tyr Pro Ile Lys Pro Arg Glu Lys Ser Glu Lys Tyr Glu Glu Arg 
385                 390                 395                 400 


Lys Glu Lys Trp Leu Lys Gln Asp Phe Asn Val Ser Leu Ile Gln Thr 
                405                 410                 415     


Ala Ile Asp Glu Tyr Asp Asn Glu Thr Val Lys Gly Lys Asn Ser Gly 
            420                 425                 430         


Lys Val Ile Val Asp Tyr Phe Ala Lys Phe Cys Asp Asp Lys Glu Thr 
        435                 440                 445             


Asp Leu Ile Gln Lys Val Asn Glu Gly Tyr Ile Ala Val Lys Asp Leu 
    450                 455                 460                 


Leu Asn Thr Pro Tyr Pro Glu Asn Glu Lys Leu Gly Ser Asn Lys Asp 
465                 470                 475                 480 


Gln Val Lys Gln Ile Lys Ala Phe Met Asp Ser Ile Met Asp Ile Met 
                485                 490                 495     


His Phe Val Arg Pro Leu Ser Leu Lys Asp Thr Asp Lys Glu Lys Asp 
            500                 505                 510         


Glu Thr Phe Tyr Ser Leu Phe Thr Pro Leu Tyr Asp His Leu Thr Gln 
        515                 520                 525             


Thr Ile Ala Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Gln Lys Pro 
    530                 535                 540                 


Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Glu Asn Ser Thr Leu Leu 
545                 550                 555                 560 


Gly Gly Trp Asp Leu Asn Lys Glu Thr Asp Asn Thr Ala Ile Ile Leu 
                565                 570                 575     


Arg Lys Glu Asn Leu Tyr Tyr Leu Gly Ile Met Asp Lys Arg His Asn 
            580                 585                 590         


Arg Ile Phe Arg Asn Val Pro Lys Ala Asp Lys Lys Asp Ser Cys Tyr 
        595                 600                 605             


Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro 
    610                 615                 620                 


Lys Val Phe Phe Ser Gln Ser Arg Ile Gln Glu Phe Thr Pro Ser Ala 
625                 630                 635                 640 


Lys Leu Leu Glu Asn Tyr Glu Asn Glu Thr His Lys Lys Gly Asp Asn 
                645                 650                 655     


Phe Asn Leu Asn His Cys His Gln Leu Ile Asp Phe Phe Lys Asp Ser 
            660                 665                 670         


Ile Asn Lys His Glu Asp Trp Lys Asn Phe Asp Phe Arg Phe Ser Ala 
        675                 680                 685             


Thr Ser Thr Tyr Ala Asp Leu Ser Gly Phe Tyr His Glu Val Glu His 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Ser Phe Gln Ser Ile Ala Asp Ser Phe Ile Asp 
705                 710                 715                 720 


Asp Leu Val Asn Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
                725                 730                 735     


Asp Phe Ser Pro Phe Ser Lys Gly Lys Pro Asn Leu His Thr Leu Tyr 
            740                 745                 750         


Trp Lys Met Leu Phe Asp Glu Asn Asn Leu Lys Asp Val Val Tyr Lys 
        755                 760                 765             


Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg Lys Lys Ser Ile Ala Glu 
    770                 775                 780                 


Lys Asn Thr Thr Ile His Lys Ala Asn Glu Ser Ile Ile Asn Lys Asn 
785                 790                 795                 800 


Pro Asp Asn Pro Lys Ala Thr Ser Thr Phe Asn Tyr Asp Ile Val Lys 
                805                 810                 815     


Asp Lys Arg Tyr Thr Ile Asp Lys Phe Gln Phe His Val Pro Ile Thr 
            820                 825                 830         


Met Asn Phe Lys Ala Glu Gly Ile Phe Asn Met Asn Gln Arg Val Asn 
        835                 840                 845             


Gln Phe Leu Lys Ala Asn Pro Asp Ile Asn Ile Ile Gly Ile Asp Arg 
    850                 855                 860                 


Gly Glu Arg His Leu Leu Tyr Tyr Thr Leu Ile Asn Gln Lys Gly Lys 
865                 870                 875                 880 


Ile Leu Lys Gln Asp Thr Leu Asn Val Ile Ala Asn Glu Lys Gln Lys 
                885                 890                 895     


Val Asp Tyr His Asn Leu Leu Asp Lys Lys Glu Gly Asp Arg Ala Thr 
            900                 905                 910         


Ala Arg Gln Glu Trp Gly Val Ile Glu Thr Ile Lys Glu Leu Lys Glu 
        915                 920                 925             


Gly Tyr Leu Ser Gln Val Ile His Lys Leu Thr Asp Leu Met Ile Glu 
    930                 935                 940                 


Asn Asn Ala Ile Ile Val Met Glu Asp Leu Asn Phe Gly Phe Lys Arg 
945                 950                 955                 960 


Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met 
                965                 970                 975     


Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Asn Lys Lys Ala Asn 
            980                 985                 990         


Glu Leu Gly Gly Leu Leu Asn Ala  Phe Gln Leu Ala Asn  Lys Phe Glu 
        995                 1000                 1005             


Ser Phe  Gln Lys Met Gly Lys  Gln Asn Gly Phe Ile  Phe Tyr Val 
    1010                 1015                 1020             


Pro Ala  Trp Asn Thr Ser Lys  Thr Asp Pro Ala Thr  Gly Phe Ile 
    1025                 1030                 1035             


Asp Phe  Leu Lys Pro Arg Tyr  Glu Asn Leu Lys Gln  Ala Lys Asp 
    1040                 1045                 1050             


Phe Phe  Glu Lys Phe Asp Ser  Ile Arg Leu Asn Ser  Lys Ala Asp 
    1055                 1060                 1065             


Tyr Phe  Glu Phe Ala Phe Asp  Phe Lys Asn Phe Thr  Gly Lys Ala 
    1070                 1075                 1080             


Asp Gly  Gly Arg Thr Lys Trp  Thr Val Cys Thr Thr  Asn Glu Asp 
    1085                 1090                 1095             


Arg Tyr  Ala Trp Asn Arg Ala  Leu Asn Asn Asn Arg  Gly Ser Gln 
    1100                 1105                 1110             


Glu Lys  Tyr Asp Ile Thr Ala  Glu Leu Lys Ser Leu  Phe Asp Gly 
    1115                 1120                 1125             


Lys Val  Asp Tyr Lys Ser Gly  Lys Asp Leu Lys Gln  Gln Ile Ala 
    1130                 1135                 1140             


Ser Gln  Glu Leu Ala Asp Phe  Phe Arg Thr Leu Met  Lys Tyr Leu 
    1145                 1150                 1155             


Ser Val  Thr Leu Ser Leu Arg  His Asn Asn Gly Glu  Lys Gly Glu 
    1160                 1165                 1170             


Thr Glu  Gln Asp Tyr Ile Leu  Ser Pro Val Ala Asp  Ser Met Gly 
    1175                 1180                 1185             


Lys Phe  Phe Asp Ser Arg Lys  Ala Gly Asp Asp Met  Pro Lys Asn 
    1190                 1195                 1200             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Trp 
    1205                 1210                 1215             


Cys Leu  Glu Gln Ile Ser Lys  Thr Asp Asp Leu Lys  Lys Val Lys 
    1220                 1225                 1230             


Leu Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Phe Met  Gln Thr Leu 
    1235                 1240                 1245             


Lys Gly  
    1250 


<210>  8
<211>  1273
<212>  PRT
<213>  Flavobacterium sp. 316

<400>  8

Met Lys Asn Phe Ser Asn Leu Tyr Gln Val Ser Lys Thr Val Arg Phe 
1               5                   10                  15      


Glu Leu Lys Pro Ile Gly Asn Thr Leu Glu Asn Ile Lys Asn Lys Ser 
            20                  25                  30          


Leu Leu Lys Asn Asp Ser Ile Arg Ala Glu Ser Tyr Gln Lys Met Lys 
        35                  40                  45              


Lys Thr Ile Asp Glu Phe His Lys Tyr Phe Ile Asp Leu Ala Leu Asn 
    50                  55                  60                  


Asn Lys Lys Leu Ser Tyr Leu Asn Glu Tyr Ile Ala Leu Tyr Thr Gln 
65                  70                  75                  80  


Ser Ala Glu Ala Lys Lys Glu Asp Lys Phe Lys Ala Asp Phe Lys Lys 
                85                  90                  95      


Val Gln Asp Asn Leu Arg Lys Glu Ile Val Ser Ser Phe Thr Glu Gly 
            100                 105                 110         


Glu Ala Lys Ala Ile Phe Ser Val Leu Asp Lys Lys Glu Leu Ile Thr 
        115                 120                 125             


Ile Glu Leu Glu Lys Trp Lys Asn Glu Asn Asn Leu Ala Val Tyr Leu 
    130                 135                 140                 


Asp Glu Ser Phe Lys Ser Phe Thr Thr Tyr Phe Thr Gly Phe His Gln 
145                 150                 155                 160 


Asn Arg Lys Asn Met Tyr Ser Ala Glu Ala Asn Ser Thr Ala Ile Ala 
                165                 170                 175     


Tyr Arg Leu Ile His Glu Asn Leu Pro Lys Phe Ile Glu Asn Ser Lys 
            180                 185                 190         


Ala Phe Glu Lys Ser Ser Gln Ile Ala Glu Leu Gln Pro Lys Ile Glu 
        195                 200                 205             


Lys Leu Tyr Lys Glu Phe Glu Ala Tyr Leu Asn Val Asn Ser Ile Ser 
    210                 215                 220                 


Glu Leu Phe Glu Ile Asp Tyr Phe Asn Glu Val Leu Thr Gln Lys Gly 
225                 230                 235                 240 


Ile Thr Val Tyr Asn Asn Ile Ile Gly Gly Arg Thr Ala Thr Glu Gly 
                245                 250                 255     


Lys Gln Lys Ile Gln Gly Leu Asn Glu Ile Ile Asn Leu Tyr Asn Gln 
            260                 265                 270         


Thr Lys Pro Lys Asn Glu Arg Leu Pro Lys Leu Lys Gln Leu Tyr Lys 
        275                 280                 285             


Gln Ile Leu Ser Asp Arg Ile Ser Leu Ser Phe Leu Pro Asp Ala Phe 
    290                 295                 300                 


Thr Glu Gly Lys Gln Val Leu Lys Ala Val Phe Glu Phe Tyr Lys Ile 
305                 310                 315                 320 


Asn Leu Leu Ser Tyr Lys Gln Asp Gly Val Glu Glu Ser Gln Asn Leu 
                325                 330                 335     


Leu Glu Leu Ile Gln Gln Val Val Lys Asn Leu Gly Asn Gln Asp Val 
            340                 345                 350         


Asn Lys Ile Tyr Leu Lys Asn Asp Thr Ser Leu Thr Thr Ile Ala Gln 
        355                 360                 365             


Gln Leu Phe Gly Asp Phe Ser Val Phe Ser Ala Ala Leu Gln Tyr Arg 
    370                 375                 380                 


Tyr Glu Thr Val Val Asn Pro Lys Tyr Thr Ala Glu Tyr Gln Lys Ala 
385                 390                 395                 400 


Asn Glu Ala Lys Gln Glu Lys Leu Asp Lys Glu Lys Ile Lys Phe Val 
                405                 410                 415     


Lys Gln Asp Tyr Phe Ser Ile Ala Phe Leu Gln Glu Val Val Ala Asp 
            420                 425                 430         


Tyr Val Lys Thr Leu Asp Glu Asn Leu Asp Trp Lys Gln Lys Tyr Thr 
        435                 440                 445             


Pro Ser Cys Ile Ala Asp Tyr Phe Thr Thr His Phe Ile Ala Lys Lys 
    450                 455                 460                 


Glu Asn Glu Ala Asp Lys Thr Phe Asn Phe Ile Ala Asn Ile Lys Ala 
465                 470                 475                 480 


Lys Tyr Gln Cys Ile Gln Gly Ile Leu Glu Gln Ala Asp Asp Tyr Glu 
                485                 490                 495     


Asp Glu Leu Lys Gln Asp Gln Lys Leu Ile Asp Asn Ile Lys Phe Phe 
            500                 505                 510         


Leu Asp Ala Ile Leu Glu Val Val His Phe Ile Lys Pro Leu His Leu 
        515                 520                 525             


Lys Ser Glu Ser Ile Thr Glu Lys Asp Asn Ala Phe Tyr Asp Val Phe 
    530                 535                 540                 


Glu Asn Tyr Tyr Glu Ala Leu Asn Val Val Thr Pro Leu Tyr Asn Met 
545                 550                 555                 560 


Val Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Thr Glu Lys Ile Lys 
                565                 570                 575     


Leu Asn Phe Glu Asn Ala Gln Leu Leu Asn Gly Trp Asp Ala Asn Lys 
            580                 585                 590         


Glu Lys Asp Tyr Leu Thr Thr Ile Leu Lys Arg Asp Gly Asn Tyr Phe 
        595                 600                 605             


Leu Ala Ile Met Asp Lys Lys His Asn Lys Thr Phe Gln Gln Phe Thr 
    610                 615                 620                 


Glu Asp Asp Glu Asn Tyr Glu Lys Ile Val Tyr Lys Leu Leu Pro Gly 
625                 630                 635                 640 


Val Asn Lys Met Leu Pro Lys Val Phe Phe Ser Asn Lys Asn Ile Ala 
                645                 650                 655     


Phe Phe Asn Pro Ser Lys Glu Ile Leu Asp Asn Tyr Lys Asn Asn Thr 
            660                 665                 670         


His Lys Lys Gly Ala Thr Phe Asn Leu Lys Asp Cys His Ala Leu Ile 
        675                 680                 685             


Asp Phe Phe Lys Asp Ser Leu Asn Lys His Glu Asp Trp Lys Tyr Phe 
    690                 695                 700                 


Asp Phe Gln Phe Ser Glu Thr Lys Thr Tyr Gln Asp Leu Ser Gly Phe 
705                 710                 715                 720 


Tyr Lys Glu Val Glu His Gln Gly Tyr Lys Ile Asn Phe Lys Lys Val 
                725                 730                 735     


Ser Val Ser Gln Ile Asp Thr Leu Ile Glu Glu Gly Lys Met Tyr Leu 
            740                 745                 750         


Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Tyr Ala Lys Gly Lys Pro 
        755                 760                 765             


Asn Met His Thr Leu Tyr Trp Lys Ala Leu Phe Glu Thr Gln Asn Leu 
    770                 775                 780                 


Glu Asn Val Ile Tyr Lys Leu Asn Gly Gln Ala Glu Ile Phe Phe Arg 
785                 790                 795                 800 


Lys Ala Ser Ile Lys Lys Lys Asn Ile Ile Thr His Lys Ala His Gln 
                805                 810                 815     


Pro Ile Ala Ala Lys Asn Pro Leu Thr Pro Thr Ala Lys Asn Thr Phe 
            820                 825                 830         


Ala Tyr Asp Leu Ile Lys Asp Lys Arg Tyr Thr Val Asp Lys Phe Gln 
        835                 840                 845             


Phe His Val Pro Ile Thr Met Asn Phe Lys Ala Thr Gly Asn Ser Tyr 
    850                 855                 860                 


Ile Asn Gln Asp Val Leu Ala Tyr Leu Lys Asp Asn Pro Glu Val Asn 
865                 870                 875                 880 


Ile Ile Gly Leu Asp Arg Gly Glu Arg His Leu Val Tyr Leu Thr Leu 
                885                 890                 895     


Ile Asp Gln Lys Gly Thr Ile Leu Leu Gln Glu Ser Leu Asn Val Ile 
            900                 905                 910         


Gln Asp Glu Lys Thr His Thr Pro Tyr His Thr Leu Leu Asp Asn Lys 
        915                 920                 925             


Glu Ile Ala Arg Asp Lys Ala Arg Lys Asn Trp Gly Ser Ile Glu Ser 
    930                 935                 940                 


Ile Lys Glu Leu Lys Glu Gly Tyr Ile Ser Gln Val Val His Lys Ile 
945                 950                 955                 960 


Thr Lys Met Met Ile Glu His Asn Ala Ile Val Val Met Glu Asp Leu 
                965                 970                 975     


Asn Phe Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Ile Tyr 
            980                 985                 990         


Gln Lys Leu Glu Lys Met Leu Ile  Asp Lys Leu Asn Tyr  Leu Val Leu 
        995                 1000                 1005             


Lys Asp  Lys Gln Pro His Glu  Leu Gly Gly Leu Tyr  Asn Ala Leu 
    1010                 1015                 1020             


Gln Leu  Thr Asn Lys Phe Glu  Ser Phe Gln Lys Met  Gly Lys Gln 
    1025                 1030                 1035             


Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Trp Asn Thr  Ser Lys Ile 
    1040                 1045                 1050             


Asp Pro  Thr Thr Gly Phe Val  Asn Tyr Phe Tyr Thr  Lys Tyr Glu 
    1055                 1060                 1065             


Asn Val  Glu Lys Ala Lys Thr  Phe Phe Ser Lys Phe  Asp Ser Ile 
    1070                 1075                 1080             


Leu Tyr  Asn Lys Thr Lys Gly  Tyr Phe Glu Phe Val  Val Lys Asn 
    1085                 1090                 1095             


Tyr Ser  Asp Phe Asn Pro Lys  Ala Ala Asp Thr Arg  Gln Glu Trp 
    1100                 1105                 1110             


Thr Ile  Cys Thr His Gly Glu  Arg Ile Glu Thr Lys  Arg Gln Lys 
    1115                 1120                 1125             


Glu Gln  Asn Asn Asn Phe Val  Ser Thr Thr Ile Gln  Leu Thr Glu 
    1130                 1135                 1140             


Gln Phe  Val Asn Phe Phe Glu  Lys Val Gly Leu Asp  Leu Ser Lys 
    1145                 1150                 1155             


Glu Leu  Lys Thr Gln Leu Ile  Ala Gln Asn Glu Lys  Ser Phe Phe 
    1160                 1165                 1170             


Glu Glu  Leu Phe His Leu Leu  Lys Leu Thr Leu Gln  Met Arg Asn 
    1175                 1180                 1185             


Ser Glu  Ser His Thr Glu Ile  Asp Tyr Leu Ile Ser  Pro Val Ala 
    1190                 1195                 1200             


Asn Glu  Lys Gly Ile Phe Tyr  Asp Ser Arg Lys Ala  Thr Ala Ser 
    1205                 1210                 1215             


Leu Pro  Ile Asp Ala Asp Ala  Asn Gly Ala Tyr His  Ile Ala Lys 
    1220                 1225                 1230             


Lys Gly  Leu Trp Ile Met Glu  Gln Ile Asn Lys Thr  Asn Ser Glu 
    1235                 1240                 1245             


Asp Asp  Leu Lys Lys Val Lys  Leu Ala Ile Ser Asn  Arg Glu Trp 
    1250                 1255                 1260             


Leu Gln  Tyr Val Gln Gln Val  Gln Lys Lys 
    1265                 1270             


<210>  9
<211>  1260
<212>  PRT
<213>  Porphyromonas crevioricanis

<400>  9

Met Asp Ser Leu Lys Asp Phe Thr Asn Leu Tyr Pro Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu Asn Ile Glu 
            20                  25                  30          


Lys Ala Gly Ile Leu Lys Glu Asp Glu His Arg Ala Glu Ser Tyr Arg 
        35                  40                  45              


Arg Val Lys Lys Ile Ile Asp Thr Tyr His Lys Val Phe Ile Asp Ser 
    50                  55                  60                  


Ser Leu Glu Asn Met Ala Lys Met Gly Ile Glu Asn Glu Ile Lys Ala 
65                  70                  75                  80  


Met Leu Gln Ser Phe Cys Glu Leu Tyr Lys Lys Asp His Arg Thr Glu 
                85                  90                  95      


Gly Glu Asp Lys Ala Leu Asp Lys Ile Arg Ala Val Leu Arg Gly Leu 
            100                 105                 110         


Ile Val Gly Ala Phe Thr Gly Val Cys Gly Arg Arg Glu Asn Thr Val 
        115                 120                 125             


Gln Asn Glu Lys Tyr Glu Ser Leu Phe Lys Glu Lys Leu Ile Lys Glu 
    130                 135                 140                 


Ile Leu Pro Asp Phe Val Leu Ser Thr Glu Ala Glu Ser Leu Pro Phe 
145                 150                 155                 160 


Ser Val Glu Glu Ala Thr Arg Ser Leu Lys Glu Phe Asp Ser Phe Thr 
                165                 170                 175     


Ser Tyr Phe Ala Gly Phe Tyr Glu Asn Arg Lys Asn Ile Tyr Ser Thr 
            180                 185                 190         


Lys Pro Gln Ser Thr Ala Ile Ala Tyr Arg Leu Ile His Glu Asn Leu 
        195                 200                 205             


Pro Lys Phe Ile Asp Asn Ile Leu Val Phe Gln Lys Ile Lys Glu Pro 
    210                 215                 220                 


Ile Ala Lys Glu Leu Glu His Ile Arg Ala Asp Phe Ser Ala Gly Gly 
225                 230                 235                 240 


Tyr Ile Lys Lys Asp Glu Arg Leu Glu Asp Ile Phe Ser Leu Asn Tyr 
                245                 250                 255     


Tyr Ile His Val Leu Ser Gln Ala Gly Ile Glu Lys Tyr Asn Ala Leu 
            260                 265                 270         


Ile Gly Lys Ile Val Thr Glu Gly Asp Gly Glu Met Lys Gly Leu Asn 
        275                 280                 285             


Glu His Ile Asn Leu Tyr Asn Gln Gln Arg Gly Arg Glu Asp Arg Leu 
    290                 295                 300                 


Pro Leu Phe Arg Pro Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Gln 
305                 310                 315                 320 


Leu Ser Tyr Leu Pro Glu Ser Phe Glu Lys Asp Glu Glu Leu Leu Arg 
                325                 330                 335     


Ala Leu Lys Glu Phe Tyr Asp His Ile Ala Glu Asp Ile Leu Gly Arg 
            340                 345                 350         


Thr Gln Gln Leu Met Thr Ser Ile Ser Glu Tyr Asp Leu Ser Arg Ile 
        355                 360                 365             


Tyr Val Arg Asn Asp Ser Gln Leu Thr Asp Ile Ser Lys Lys Met Leu 
    370                 375                 380                 


Gly Asp Trp Asn Ala Ile Tyr Met Ala Arg Glu Arg Ala Tyr Asp His 
385                 390                 395                 400 


Glu Gln Ala Pro Lys Arg Ile Thr Ala Lys Tyr Glu Arg Asp Arg Ile 
                405                 410                 415     


Lys Ala Leu Lys Gly Glu Glu Ser Ile Ser Leu Ala Asn Leu Asn Ser 
            420                 425                 430         


Cys Ile Ala Phe Leu Asp Asn Val Arg Asp Cys Arg Val Asp Thr Tyr 
        435                 440                 445             


Leu Ser Thr Leu Gly Gln Lys Glu Gly Pro His Gly Leu Ser Asn Leu 
    450                 455                 460                 


Val Glu Asn Val Phe Ala Ser Tyr His Glu Ala Glu Gln Leu Leu Ser 
465                 470                 475                 480 


Phe Pro Tyr Pro Glu Glu Asn Asn Leu Ile Gln Asp Lys Asp Asn Val 
                485                 490                 495     


Val Leu Ile Lys Asn Leu Leu Asp Asn Ile Ser Asp Leu Gln Arg Phe 
            500                 505                 510         


Leu Lys Pro Leu Trp Gly Met Gly Asp Glu Pro Asp Lys Asp Glu Arg 
        515                 520                 525             


Phe Tyr Gly Glu Tyr Asn Tyr Ile Arg Gly Ala Leu Asp Gln Val Ile 
    530                 535                 540                 


Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Arg Lys Pro Tyr Ser 
545                 550                 555                 560 


Thr Arg Lys Val Lys Leu Asn Phe Gly Asn Ser Gln Leu Leu Ser Gly 
                565                 570                 575     


Trp Asp Arg Asn Lys Glu Lys Asp Asn Ser Cys Val Ile Leu Arg Lys 
            580                 585                 590         


Gly Gln Asn Phe Tyr Leu Ala Ile Met Asn Asn Arg His Lys Arg Ser 
        595                 600                 605             


Phe Glu Asn Lys Met Leu Pro Glu Tyr Lys Glu Gly Glu Pro Tyr Phe 
    610                 615                 620                 


Glu Lys Met Asp Tyr Lys Phe Leu Pro Asp Pro Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Leu Ser Lys Lys Gly Ile Glu Ile Tyr Lys Pro Ser Pro 
                645                 650                 655     


Lys Leu Leu Glu Gln Tyr Gly His Gly Thr His Lys Lys Gly Asp Thr 
            660                 665                 670         


Phe Ser Met Asp Asp Leu His Glu Leu Ile Asp Phe Phe Lys His Ser 
        675                 680                 685             


Ile Glu Ala His Glu Asp Trp Lys Gln Phe Gly Phe Lys Phe Ser Asp 
    690                 695                 700                 


Thr Ala Thr Tyr Glu Asn Val Ser Ser Phe Tyr Arg Glu Val Glu Asp 
705                 710                 715                 720 


Gln Gly Tyr Lys Leu Ser Phe Arg Lys Val Ser Glu Ser Tyr Val Tyr 
                725                 730                 735     


Ser Leu Ile Asp Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
            740                 745                 750         


Asp Phe Ser Pro Cys Ser Lys Gly Thr Pro Asn Leu His Thr Leu Tyr 
        755                 760                 765             


Trp Arg Met Leu Phe Asp Glu Arg Asn Leu Ala Asp Val Ile Tyr Lys 
    770                 775                 780                 


Leu Asp Gly Lys Ala Glu Ile Phe Phe Arg Glu Lys Ser Leu Lys Asn 
785                 790                 795                 800 


Asp His Pro Thr His Pro Ala Gly Lys Pro Ile Lys Lys Lys Ser Arg 
                805                 810                 815     


Gln Lys Lys Gly Glu Glu Ser Leu Phe Glu Tyr Asp Leu Val Lys Asp 
            820                 825                 830         


Arg Arg Tyr Thr Met Asp Lys Phe Gln Phe His Val Pro Ile Thr Met 
        835                 840                 845             


Asn Phe Lys Cys Ser Ala Gly Ser Lys Val Asn Asp Met Val Asn Ala 
    850                 855                 860                 


His Ile Arg Glu Ala Lys Asp Met His Val Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg Asn Leu Leu Tyr Ile Cys Val Ile Asp Ser Arg Gly Thr Ile 
                885                 890                 895     


Leu Asp Gln Ile Ser Leu Asn Thr Ile Asn Asp Ile Asp Tyr His Asp 
            900                 905                 910         


Leu Leu Glu Ser Arg Asp Lys Asp Arg Gln Gln Glu His Arg Asn Trp 
        915                 920                 925             


Gln Thr Ile Glu Gly Ile Lys Glu Leu Lys Gln Gly Tyr Leu Ser Gln 
    930                 935                 940                 


Ala Val His Arg Ile Ala Glu Leu Met Val Ala Tyr Lys Ala Val Val 
945                 950                 955                 960 


Ala Leu Glu Asp Leu Asn Met Gly Phe Lys Arg Gly Arg Gln Lys Val 
                965                 970                 975     


Glu Ser Ser Val Tyr Gln Gln Phe Glu Lys Gln Leu Ile Asp Lys Leu 
            980                 985                 990         


Asn Tyr Leu Val Asp Lys Lys Lys  Arg Pro Glu Asp Ile  Gly Gly Leu 
        995                 1000                 1005             


Leu Arg  Ala Tyr Gln Phe Thr  Ala Pro Phe Lys Ser  Phe Lys Glu 
    1010                 1015                 1020             


Met Gly  Lys Gln Asn Gly Phe  Leu Phe Tyr Ile Pro  Ala Trp Asn 
    1025                 1030                 1035             


Thr Ser  Asn Ile Asp Pro Thr  Thr Gly Phe Val Asn  Leu Phe His 
    1040                 1045                 1050             


Val Gln  Tyr Glu Asn Val Asp  Lys Ala Lys Ser Phe  Phe Gln Lys 
    1055                 1060                 1065             


Phe Asp  Ser Ile Ser Tyr Asn  Pro Lys Lys Asp Trp  Phe Glu Phe 
    1070                 1075                 1080             


Ala Phe  Asp Tyr Lys Asn Phe  Thr Lys Lys Ala Glu  Gly Ser Arg 
    1085                 1090                 1095             


Ser Met  Trp Ile Leu Cys Thr  His Gly Ser Arg Ile  Lys Asn Phe 
    1100                 1105                 1110             


Arg Asn  Ser Gln Lys Asn Gly  Gln Trp Asp Ser Glu  Glu Phe Ala 
    1115                 1120                 1125             


Leu Thr  Glu Ala Phe Lys Ser  Leu Phe Val Arg Tyr  Glu Ile Asp 
    1130                 1135                 1140             


Tyr Thr  Ala Asp Leu Lys Thr  Ala Ile Val Asp Glu  Lys Gln Lys 
    1145                 1150                 1155             


Asp Phe  Phe Val Asp Leu Leu  Lys Leu Phe Lys Leu  Thr Val Gln 
    1160                 1165                 1170             


Met Arg  Asn Ser Trp Lys Glu  Lys Asp Leu Asp Tyr  Leu Ile Ser 
    1175                 1180                 1185             


Pro Val  Ala Gly Ala Asp Gly  Arg Phe Phe Asp Thr  Arg Glu Gly 
    1190                 1195                 1200             


Asn Lys  Ser Leu Pro Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1205                 1210                 1215             


Ile Ala  Leu Lys Gly Leu Trp  Ala Leu Arg Gln Ile  Arg Gln Thr 
    1220                 1225                 1230             


Ser Glu  Gly Gly Lys Leu Lys  Leu Ala Ile Ser Asn  Lys Glu Trp 
    1235                 1240                 1245             


Leu Gln  Phe Val Gln Glu Arg  Ser Tyr Glu Lys Asp  
    1250                 1255                 1260 


<210>  10
<211>  1262
<212>  PRT
<213>  Bacteroidetes oral taxon 274

<400>  10

Met Arg Lys Phe Asn Glu Phe Val Gly Leu Tyr Pro Ile Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Glu His Ile Gln 
            20                  25                  30          


Arg Asn Lys Leu Leu Glu His Asp Ala Val Arg Ala Asp Asp Tyr Val 
        35                  40                  45              


Lys Val Lys Lys Ile Ile Asp Lys Tyr His Lys Cys Leu Ile Asp Glu 
    50                  55                  60                  


Ala Leu Ser Gly Phe Thr Phe Asp Thr Glu Ala Asp Gly Arg Ser Asn 
65                  70                  75                  80  


Asn Ser Leu Ser Glu Tyr Tyr Leu Tyr Tyr Asn Leu Lys Lys Arg Asn 
                85                  90                  95      


Glu Gln Glu Gln Lys Thr Phe Lys Thr Ile Gln Asn Asn Leu Arg Lys 
            100                 105                 110         


Gln Ile Val Asn Lys Leu Thr Gln Ser Glu Lys Tyr Lys Arg Ile Asp 
        115                 120                 125             


Lys Lys Glu Leu Ile Thr Thr Asp Leu Pro Asp Phe Leu Thr Asn Glu 
    130                 135                 140                 


Ser Glu Lys Glu Leu Val Glu Lys Phe Lys Asn Phe Thr Thr Tyr Phe 
145                 150                 155                 160 


Thr Glu Phe His Lys Asn Arg Lys Asn Met Tyr Ser Lys Glu Glu Lys 
                165                 170                 175     


Ser Thr Ala Ile Ala Phe Arg Leu Ile Asn Glu Asn Leu Pro Lys Phe 
            180                 185                 190         


Val Asp Asn Ile Ala Ala Phe Glu Lys Val Val Ser Ser Pro Leu Ala 
        195                 200                 205             


Glu Lys Ile Asn Ala Leu Tyr Glu Asp Phe Lys Glu Tyr Leu Asn Val 
    210                 215                 220                 


Glu Glu Ile Ser Arg Val Phe Arg Leu Asp Tyr Tyr Asp Glu Leu Leu 
225                 230                 235                 240 


Thr Gln Lys Gln Ile Asp Leu Tyr Asn Ala Ile Val Gly Gly Arg Thr 
                245                 250                 255     


Glu Glu Asp Asn Lys Ile Gln Ile Lys Gly Leu Asn Gln Tyr Ile Asn 
            260                 265                 270         


Glu Tyr Asn Gln Gln Gln Thr Asp Arg Ser Asn Arg Leu Pro Lys Leu 
        275                 280                 285             


Lys Pro Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Ser Val Ser Trp 
    290                 295                 300                 


Leu Pro Pro Lys Phe Asp Ser Asp Lys Asn Leu Leu Ile Lys Ile Lys 
305                 310                 315                 320 


Glu Cys Tyr Asp Ala Leu Ser Glu Lys Glu Lys Val Phe Asp Lys Leu 
                325                 330                 335     


Glu Ser Ile Leu Lys Ser Leu Ser Thr Tyr Asp Leu Ser Lys Ile Tyr 
            340                 345                 350         


Ile Ser Asn Asp Ser Gln Leu Ser Tyr Ile Ser Gln Lys Met Phe Gly 
        355                 360                 365             


Arg Trp Asp Ile Ile Ser Lys Ala Ile Arg Glu Asp Cys Ala Lys Arg 
    370                 375                 380                 


Asn Pro Gln Lys Ser Arg Glu Ser Leu Glu Lys Phe Ala Glu Arg Ile 
385                 390                 395                 400 


Asp Lys Lys Leu Lys Thr Ile Asp Ser Ile Ser Ile Gly Asp Val Asp 
                405                 410                 415     


Glu Cys Leu Ala Gln Leu Gly Glu Thr Tyr Val Lys Arg Val Glu Asp 
            420                 425                 430         


Tyr Phe Val Ala Met Gly Glu Ser Glu Ile Asp Asp Glu Gln Thr Asp 
        435                 440                 445             


Thr Thr Ser Phe Lys Lys Asn Ile Glu Gly Ala Tyr Glu Ser Val Lys 
    450                 455                 460                 


Glu Leu Leu Asn Asn Ala Asp Asn Ile Thr Asp Asn Asn Leu Met Gln 
465                 470                 475                 480 


Asp Lys Gly Asn Val Glu Lys Ile Lys Thr Leu Leu Asp Ala Ile Lys 
                485                 490                 495     


Asp Leu Gln Arg Phe Ile Lys Pro Leu Leu Gly Lys Gly Asp Glu Ala 
            500                 505                 510         


Asp Lys Asp Gly Val Phe Tyr Gly Glu Phe Thr Ser Leu Trp Thr Lys 
        515                 520                 525             


Leu Asp Gln Val Thr Pro Leu Tyr Asn Met Val Arg Asn Tyr Leu Thr 
    530                 535                 540                 


Ser Lys Pro Tyr Ser Thr Lys Lys Ile Lys Leu Asn Phe Glu Asn Ser 
545                 550                 555                 560 


Thr Leu Met Asp Gly Trp Asp Leu Asn Lys Glu Pro Asp Asn Thr Thr 
                565                 570                 575     


Val Ile Phe Cys Lys Asp Gly Leu Tyr Tyr Leu Gly Ile Met Gly Lys 
            580                 585                 590         


Lys Tyr Asn Arg Val Phe Val Asp Arg Glu Asp Leu Pro His Asp Gly 
        595                 600                 605             


Glu Cys Tyr Asp Lys Met Glu Tyr Lys Leu Leu Pro Gly Ala Asn Lys 
    610                 615                 620                 


Met Leu Pro Lys Val Phe Phe Ser Glu Thr Gly Ile Gln Arg Phe Leu 
625                 630                 635                 640 


Pro Ser Glu Glu Leu Leu Gly Lys Tyr Glu Arg Gly Thr His Lys Lys 
                645                 650                 655     


Gly Ala Gly Phe Asp Leu Gly Asp Cys Arg Ala Leu Ile Asp Phe Phe 
            660                 665                 670         


Lys Lys Ser Ile Glu Arg His Asp Asp Trp Lys Lys Phe Asp Phe Lys 
        675                 680                 685             


Phe Ser Asp Thr Ser Thr Tyr Gln Asp Ile Ser Glu Phe Tyr Arg Glu 
    690                 695                 700                 


Val Glu Gln Gln Gly Tyr Lys Met Ser Phe Arg Lys Val Ser Val Asp 
705                 710                 715                 720 


Tyr Ile Lys Ser Leu Val Glu Glu Gly Lys Leu Tyr Leu Phe Gln Ile 
                725                 730                 735     


Tyr Asn Lys Asp Phe Ser Ala His Ser Lys Gly Thr Pro Asn Met His 
            740                 745                 750         


Thr Leu Tyr Trp Lys Met Leu Phe Asp Glu Glu Asn Leu Lys Asp Val 
        755                 760                 765             


Val Tyr Lys Leu Asn Gly Glu Ala Glu Val Phe Phe Arg Lys Ser Ser 
    770                 775                 780                 


Ile Thr Val Gln Ser Pro Thr His Pro Ala Asn Ser Pro Ile Lys Asn 
785                 790                 795                 800 


Lys Asn Lys Asp Asn Gln Lys Lys Glu Ser Lys Phe Glu Tyr Asp Leu 
                805                 810                 815     


Ile Lys Asp Arg Arg Tyr Thr Val Asp Lys Phe Leu Phe His Val Pro 
            820                 825                 830         


Ile Thr Met Asn Phe Lys Ser Val Gly Gly Ser Asn Ile Asn Gln Leu 
        835                 840                 845             


Val Lys Arg His Ile Arg Ser Ala Thr Asp Leu His Ile Ile Gly Ile 
    850                 855                 860                 


Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Val Ile Asp Ser Arg 
865                 870                 875                 880 


Gly Asn Ile Lys Glu Gln Phe Ser Leu Asn Glu Ile Val Asn Glu Tyr 
                885                 890                 895     


Asn Gly Asn Thr Tyr Arg Thr Asp Tyr His Glu Leu Leu Asp Thr Arg 
            900                 905                 910         


Glu Gly Glu Arg Thr Glu Ala Arg Arg Asn Trp Gln Thr Ile Gln Asn 
        915                 920                 925             


Ile Arg Glu Leu Lys Glu Gly Tyr Leu Ser Gln Val Ile His Lys Ile 
    930                 935                 940                 


Ser Glu Leu Ala Ile Lys Tyr Asn Ala Val Ile Val Leu Glu Asp Leu 
945                 950                 955                 960 


Asn Phe Gly Phe Met Arg Ser Arg Gln Lys Val Glu Lys Gln Val Tyr 
                965                 970                 975     


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp 
            980                 985                 990         


Lys Lys Lys Pro Val Ala Glu Thr  Gly Gly Leu Leu Arg  Ala Tyr Gln 
        995                 1000                 1005             


Leu Thr  Gly Glu Phe Glu Ser  Phe Lys Thr Leu Gly  Lys Gln Ser 
    1010                 1015                 1020             


Gly Ile  Leu Phe Tyr Val Pro  Ala Trp Asn Thr Ser  Lys Ile Asp 
    1025                 1030                 1035             


Pro Val  Thr Gly Phe Val Asn  Leu Phe Asp Thr His  Tyr Glu Asn 
    1040                 1045                 1050             


Ile Glu  Lys Ala Lys Val Phe  Phe Asp Lys Phe Lys  Ser Ile Arg 
    1055                 1060                 1065             


Tyr Asn  Ser Asp Lys Asp Trp  Phe Glu Phe Val Val  Asp Asp Tyr 
    1070                 1075                 1080             


Thr Arg  Phe Ser Pro Lys Ala  Glu Gly Thr Arg Arg  Asp Trp Thr 
    1085                 1090                 1095             


Ile Cys  Thr Gln Gly Lys Arg  Ile Gln Ile Cys Arg  Asn His Gln 
    1100                 1105                 1110             


Arg Asn  Asn Glu Trp Glu Gly  Gln Glu Ile Asp Leu  Thr Lys Ala 
    1115                 1120                 1125             


Phe Lys  Glu His Phe Glu Ala  Tyr Gly Val Asp Ile  Ser Lys Asp 
    1130                 1135                 1140             


Leu Arg  Glu Gln Ile Asn Thr  Gln Asn Lys Lys Glu  Phe Phe Glu 
    1145                 1150                 1155             


Glu Leu  Leu Arg Leu Leu Arg  Leu Thr Leu Gln Met  Arg Asn Ser 
    1160                 1165                 1170             


Met Pro  Ser Ser Asp Ile Asp  Tyr Leu Ile Ser Pro  Val Ala Asn 
    1175                 1180                 1185             


Asp Thr  Gly Cys Phe Phe Asp  Ser Arg Lys Gln Ala  Glu Leu Lys 
    1190                 1195                 1200             


Glu Asn  Ala Val Leu Pro Met  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1205                 1210                 1215             


Asn Ile  Ala Arg Lys Gly Leu  Leu Ala Ile Arg Lys  Met Lys Gln 
    1220                 1225                 1230             


Glu Glu  Asn Asp Ser Ala Lys  Ile Ser Leu Ala Ile  Ser Asn Lys 
    1235                 1240                 1245             


Glu Trp  Leu Lys Phe Ala Gln  Thr Lys Pro Tyr Leu  Glu Asp 
    1250                 1255                 1260         


<210>  11
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pre-crRNA

<400>  11
gggucuaaga acuuuaaaua auuucuacug uuguacau                               38


<210>  12
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  12
agctgataag taaattacca tcaatagttt ctggatataa taatttaaga ttaaaaggta       60

attctatctt gttgagatct gagctttctt ctatatgatt aatatttgct ac              112


<210>  13
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  13
agctgtagca aatattaatc atatagaaga aagctcagat ctcaacaaga tagaattacc       60

ttttaatctt aaattattat atccagaaac tattgatggt aatttactta tc              112


<210>  14
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  14
uucuacuggu guagauagau uaaaagguaa uucuaucu                               38


<210>  15
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR array

<400>  15
atgcgauuca uagagaacaa gagguuguuu uuauagacua aaaauugcaa accuuagucu       60

uuauguuaaa auaacuacua aguucuuaga gauauuuaaa aauaugacug uuguuauaua      120

ucaaaaugcu aaaaaaauca uagauuuuag gucuuuuuuu gcugauuuag gcaaaaacgg      180

gucuaagaac uuuaaauaau uucuacuguu guagaugaga agucauuuaa uaaggccacu      240

guuaaaaguc uaagaacuuu aaauaauuuc uacuguugua gaugcuacua uuccugugcc      300

uucagauaau ucagucuaag aacuuuaaau aauuucuacu guuguagaug ucuagagccu      360

uuuguauuag uagccggucu aagaacuuua aauaauuucu acuguuguag auuagcgauu      420

uaugaagguc auuuuuuugu cuaagaacuu uaaauaauuu cuacuguugu agauagauua      480

aaagguaauu cuaucuuguu gaggucuaag aacuuuaaau aauuucuacu guuguagauu      540

accuaguaga uacgcuuacu gauaacaagu cuaagaacuu uaaauaauuu cuacuguugu      600

agauaaacuu ucauuuauga uauaaaguuu uuugucuaag aacuuuaaau aauuucuacu      660

guuguagauu caaaaggcaa gagagacgga aauaaaugga cgucuaagaa cuuuaaauaa      720

uuucuacugu uguagauuug uuugauugcu ugcauuga                              758


<210>  16
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 cleavage product

<400>  16
gguagauuaa aagguaauuc uaucu                                             25


<210>  17
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 cleavage product

<400>  17
gguucuacug uuguagauag auuaaaaggu aauucuaucu                             40


<210>  18
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 cleavage product

<400>  18
gggucuaaga acuuuaaaua auuucuacug uuguagauag auuaaaaggu aauucuaucu       60

uguugag                                                                 67


<210>  19
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Cpf1 cleavage product

<400>  19
gggucuaaga acuuuaaaua auuucuacug uuguagauag auuaaaaggu aauucuaucu       60

uguugagguc uaagaacuuu aaauaauuuc uacuguugua gau                        103


<210>  20
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pre-crRNA with spacer

<400>  20
gggucuaaga acuuuaaaua auuucuacug uuguagau                               38


<210>  21
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pre-crRNA with spacer

<400>  21
aauaauuuga ugaacacauc au                                                22


<210>  22
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pre-crRNA with spacer

<400>  22
aauaauuucu acuguucauc au                                                22


<210>  23
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pre-crRNA with spacer

<400>  23
aauuuaaucu acuguuguag au                                                22


<210>  24
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pre-crRNA with spacer

<400>  24
aauaauuucu cuguugagau                                                   20


<210>  25
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pre-crRNA with spacer

<400>  25
aauaauuucu acguguucgu agau                                              24


<210>  26
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pre-crRNA with spacer

<400>  26
aauaauuucg uguacguguu cguacacgau                                        30


<210>  27
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  27
gguucuacug uuguagauua gcgauuuaug aaggucauuu uu                          42


<210>  28
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  28
gguagauuaa aagguaauuc uaucu                                             25


<210>  29
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  29
gguucuacug uuguagauag auuaaaaggu aauucuaucu                             40


<210>  30
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  30
gggucuaaga acuuuaaaua auuucuacug uuguagauag auuaaaaggu aauucuaucu       60

uguugag                                                                 67


<210>  31
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  31
ggagauuaaa agguaauucu aucuuguuga ggucuaagaa cuuuaaauaa uuucuacugu       60

uguagau                                                                 67


<210>  32
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  32
gggucuaaga acuuuaaaua auuucuacug uuguagauag auuaaaaggu aauucuaucu       60

uguugagguc uaagaacuuu aaauaauuuc uacuguugua gau                        103


<210>  33
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  33
gguugaugaa cacaucauag auuaaaaggu aauucuaucu                             40


<210>  34
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  34
gguucuacug uucaucauag auuaaaaggu aauucuaucu                             40


<210>  35
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  non-target

<400>  35
atttaagatt aaaaggtaat tctatcttgt tgagat                                 36


<210>  36
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target

<400>  36
atctcaacaa gatagaatta ccttttaatc ttaaat                                 36


<210>  37
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  37
uucuacuggu guagauagau uaaaagguaa uucuaucu                               38


<210>  38
<211>  1300
<212>  PRT
<213>  F. novicida U112

<400>  38

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  39
<211>  11
<212>  PRT
<213>  HIV-1

<400>  39

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  40
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  40

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  41
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  41

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  42

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  43

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  44

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  45

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  46

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  47

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  48

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein Transduction Domain

<400>  49

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  50
<211>  16
<212>  PRT
<213>  Drosophila melanogaster

<400>  50

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  51
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  51
agctgtagca aatattaatc atatagaaga aagctcagat ctcaacaaga tagaattacc       60

ttttaatctt aaattattat atccagaaac tattgatggt aatttactta tc              112


<210>  52
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  52
agctgataag taaattacca tcaatagttt ctggatataa taatttaaga ttaaaaggta       60

attctatctt gttgagatct gagctttctt ctatatgatt aatatttgct ac              112


<210>  53
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  53
agctgagata gaattacctt ttaatctc                                          28


<210>  54
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  54
agctgagatt aaaaggtaat tctatctc                                          28


<210>  55
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  55
gacggccagt gcagtcgagc tcgg                                              24


<210>  56
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  56
ccttttaatc tccgcttgca tgcctg                                            26


<210>  57
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  57
agctgcgata gaattacctt ttaatctc                                          28


<210>  58
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  58
agctgagatt aaaaggtaat tctatcgc                                          28


<210>  59
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  59
agctgatata gaattacctt ttaatctc                                          28


<210>  60
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  60
agctgagatt aaaaggtaat tctatatc                                          28


<210>  61
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  61
agctgagcta gaattacctt ttaatctc                                          28


<210>  62
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  62
agctgagatt aaaaggtaat tctagctc                                          28


<210>  63
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  63
agctgagaga gaattacctt ttaatctc                                          28


<210>  64
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  64
agctgagatt aaaaggtaat tctctctc                                          28


<210>  65
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  65
agctgagatc gaattacctt ttaatctc                                          28


<210>  66
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  66
agctgagatt aaaaggtaat tcgatctc                                          28


<210>  67
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  67
agctgagata taattacctt ttaatctc                                          28


<210>  68
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  68
agctgagatt aaaaggtaat tatatctc                                          28


<210>  69
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  69
agctgagata gcattacctt ttaatctc                                          28


<210>  70
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  70
agctgagatt aaaaggtaat gctatctc                                          28


<210>  71
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  71
agctgagata gacttacctt ttaatctc                                          28


<210>  72
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  72
agctgagatt aaaaggtaag tctatctc                                          28


<210>  73
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  73
agctgagata gaagtacctt ttaatctc                                          28


<210>  74
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  74
agctgagatt aaaaggtact tctatctc                                          28


<210>  75
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  75
agctgagata gaatgacctt ttaatctc                                          28


<210>  76
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  76
agctgagatt aaaaggtcat tctatctc                                          28


<210>  77
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  77
agctgagata gaattccctt ttaatctc                                          28


<210>  78
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  78
agctgagatt aaaagggaat tctatctc                                          28


<210>  79
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  79
agctgagata gaattaactt ttaatctc                                          28


<210>  80
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  80
agctgagatt aaaagttaat tctatctc                                          28


<210>  81
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  81
agctgagata gaattacatt ttaatctc                                          28


<210>  82
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  82
agctgagatt aaaatgtaat tctatctc                                          28


<210>  83
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  83
agctgagata gaattaccgt ttaatctc                                          28


<210>  84
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  84
agctgagatt aaacggtaat tctatctc                                          28


<210>  85
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  85
agctgagata gaattacctg ttaatctc                                          28


<210>  86
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  86
agctgagatt aacaggtaat tctatctc                                          28


<210>  87
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  87
agctgagata gaattacctt gtaatctc                                          28


<210>  88
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  88
agctgagatt acaaggtaat tctatctc                                          28


<210>  89
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  89
agctgagata gaattacctt tgaatctc                                          28


<210>  90
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  90
agctgagatt caaaggtaat tctatctc                                          28


<210>  91
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  91
agctgagata gaattacctt ttcatctc                                          28


<210>  92
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  92
agctgagatg aaaaggtaat tctatctc                                          28


<210>  93
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  93
agctgagata gaattacctt ttactctc                                          28


<210>  94
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  94
agctgagagt aaaaggtaat tctatctc                                          28


<210>  95
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  95
agctgagata gaattacctt ttaagctc                                          28


<210>  96
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  96
agctgagctt aaaaggtaat tctatctc                                          28


<210>  97
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  97
agctgagata gaattacctt ttaatatc                                          28


<210>  98
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  98
agctgatatt aaaaggtaat tctatctc                                          28


<210>  99
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  99
agctgagata gaattacctt ttaatcgc                                          28


<210>  100
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  100
agctgcgatt aaaaggtaat tctatctc                                          28


<210>  101
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  101
agctgctcga gaattacctt ttaatctc                                          28


<210>  102
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  102
agctgagatt aaaaggtaat tctcgagc                                          28


<210>  103
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  103
agctgagata gaattacctt ttacgagc                                          28


<210>  104
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  104
agctgctcgt aaaaggtaat tctatctc                                          28


<210>  105
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  105
gacggccagt gcagtcgagc tcgg                                              24


<210>  106
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  106
ccttttaatc tcatcttgca tgcctg                                            26


<210>  107
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  107
gacggccagt gcagtcgagc tcgg                                              24


<210>  108
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  108
ccttttaatc tcctctttca tgcctg                                            26


<210>  109
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  109
gacggccagt gcagtcgagc tcgg                                              24


<210>  110
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  110
ccttttaatc tcggcttgca tgcctg                                            26


<210>  111
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  111
agctgtaatc atatagaaga aagctcagat ctcaacaaga tagaattacc ttttaatctt       60

aaattattat atccagaaac tattgatggt ac                                     92


<210>  112
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  112
agctgtacca tcaatagttt ctggatataa taatttaaga ttaaaaggta attctatctt       60

gttgagatct gagctttctt ctatatgatt ac                                     92


<210>  113
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  113
agctgtaatc atatagaaga aagctcagat ctcaacaaga tagaattacc ttttaatctt       60

ttatttttat atccagaaac tattgatggt ac                                     92


<210>  114
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  114
agctgtacca tcaatagttt ctggatataa aaataaaaga ttaaaaggta attctatctt       60

gttgagatct gagctttctt ctatatgatt ac                                     92


<210>  115
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  115
agctgtaatc atatagaaga aagctcagat ctcaacaaga tagaattacc ttttaatctt       60

ttattattat atccagaaac tattgatggt ac                                     92


<210>  116
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  116
agctgtacca tcaatagttt ctggatataa taataaaaga ttaaaaggta attctatctt       60

gttgagatct gagctttctt ctatatgatt ac                                     92


<210>  117
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  117
agctgtaatc atatagaaga aagctcagat ctcaacaaga tagaattacc ttttaatctt       60

ggattattat atccagaaac tattgatggt ac                                     92


<210>  118
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  118
agctgtacca tcaatagttt ctggatataa taatccaaga ttaaaaggta attctatctt       60

gttgagatct gagctttctt ctatatgatt ac                                     92


<210>  119
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  119
agctgtagca aatattaatc atatagaaga aagctcagat ctcaacaaga tagaattacc       60

ttttaatctt aaattattat atccagaaac tattgatggt aatttactta tc              112


<210>  120
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  120
agctgataag taaattacca tcaatagttt ctggatataa taatttaaga ttaaaaggta       60

attctatctt gttgagatct gagctttctt ctatatgatt aatatttgct ac              112


<210>  121
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  121
taatacgact cactata                                                      17


<210>  122
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  122
aaaaatgacc ttcataaatc gctaatctac aacagtagaa cctatagtga gtcgtatta        59


<210>  123
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  123
agatagaatt accttttaat ctacctatag tgagtcgtat ta                          42


<210>  124
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  124
agatagaatt accttttaat ctatctacaa cagtagaacc tatagtgagt cgtatta          57


<210>  125
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  125
ctcaacaaga tagaattacc ttttaatcta tctacaacag tagaaattat ttaaagttct       60

tagaccctat agtgagtcgt atta                                              84


<210>  126
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  126
atctacaaca gtagaaatta tttaaagttc ttagacctca acaagataga attacctttt       60

aatctcctat agtgagtcgt atta                                              84


<210>  127
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  127
atctacaaca gtagaaatta tttaaagttc ttagacctca acaagataga attacctttt       60

aatctatcta caacagtaga aattatttaa agttcttaga ccctatagtg agtcgtatta      120


<210>  128
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  128
agatagaatt accttttaat ctatgatgaa cagtagaacc tatagtgagt cgtatta          57


<210>  129
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  129
agatagaatt accttttaat ctatgatgtg ttcatcaacc tatagtgagt cgtatta          57


<210>  130
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  130
ctcaacaaga tagaattacc ttttaatcta tgatgaacag tagaaattat ttaaagttct       60

tagaccctat agtgagtcgt atta                                              84


<210>  131
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  131
ctcaacaaga tagaattacc ttttaatcta tgatgaacag tagaaattat ttaaagttct       60

tagaccctat agtgagtcgt atta                                              84


<210>  132
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  132
atgcaggtcg acatgtcaat ttatcaagaa tttg                                   34


<210>  133
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  133
agctagcggc cgcttagtta ttcctattct gcacg                                  35


<210>  134
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  134
atgcagggta ccatgtcaat ttatcaagaa tttg                                   34


<210>  135
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  135
agctacggcc gttagttatt cctattctgc acg                                    33


<210>  136
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  136
tcgtaaacaa tcaataccta aaaaaatcac tgccccagct aaagaggca                   49


<210>  137
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  137
tgcctcttta gctggggcag tgattttttt aggtattgat tgtttacga                   49


<210>  138
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  138
ctctttttta ggattatctt tgtttgcatt agctattgcc tctttagctg ggt              53


<210>  139
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  139
acccagctaa agaggcaata gctaatgcaa acaaagataa tcctaaaaaa gag              53


<210>  140
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  140
gaaaaactta tcttcagtaa agcgtttatc tgcgattaaa tcatattcaa aaacactctc       60

tttt                                                                    64


<210>  141
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  141
aaaagagagt gtttttgaat atgatttaat cgcagataaa cgctttactg aagataagtt       60

tttc                                                                    64


<210>  142
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  142
ggacagtgaa agaaaaactt atcttcagta gcgcgtttat ctttgattaa atcatattca       60

aa                                                                      62


<210>  143
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  143
tttgaatatg atttaatcaa agataaacgc gctactgaag ataagttttt ctttcactgt       60

cc                                                                      62


<210>  144
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  144
aagctaaatg tctttcacct ctagctatac ttaatatatg aacatcattt gct              53


<210>  145
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  145
agcaaatgat gttcatatat taagtatagc tagaggtgaa agacatttag ctt              53


<210>  146
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  146
tcatatatta agtatagata gaggtgcaag acatttagct tactatactt tgg              53


<210>  147
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  147
ccaaagtata gtaagctaaa tgtcttgcac ctctatctat acttaatata tga              53


<210>  148
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  148
ccatctacca aagtatagta agctaaagct ctttcacctc tatctatact taatat           56


<210>  149
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  149
atattaagta tagatagagg tgaaagagct ttagcttact atactttggt agatgg           56


<210>  150
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  150
cctttaccat ctaccaaagt ataggcagct aaatgtcttt cacctctatc                  50


<210>  151
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  151
gatagaggtg aaagacattt agctgcctat actttggtag atggtaaagg                  50


<210>  152
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  152
ctcttttaaa tccaaaattt aaatccgcaa aaaccacaat agcattatac tctataact        59


<210>  153
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  153
agttatagag tataatgcta ttgtggtttt tgcggattta aattttggat ttaaaagag        59


<210>  154
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  154
aattagcatt ttttctaact tttgagcgac ctgcttctct accttgaaac g                51


<210>  155
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  155
cgtttcaagg tagagaagca ggtcgctcaa aagttagaaa aaatgctaat t                51


<210>  156
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  156
gtttagtttc tcaattagca tttttgctaa cttttgatag acctgcttct c                51


<210>  157
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  157
gagaagcagg tctatcaaaa gttagcaaaa atgctaattg agaaactaaa c                51


<210>  158
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  158
ctgctactgg tgaaattaga taagctaact cagtacctgt ttttgag                     47


<210>  159
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  159
ctcaaaaaca ggtactgagt tagcttatct aatttcacca gtagcag                     47


<210>  160
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  160
gataagcacc attggcagca gcatcttgag gcata                                  35


<210>  161
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  161
tatgcctcaa gatgctgctg ccaatggtgc ttatc                                  35


<210>  162
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  162
atcaagccct tcatgcgctt caaggtgca                                         29


<210>  163
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  163
agtttaggta ccttattttc tccactctaa acttgat                                37


<210>  164
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  164
atattcaaca tattgaccgg cctgcagagt aaggatgttg ggtctac                     47


<210>  165
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  165
ctcaacaaga tagaattacc ttttaatcta tgatgaacag tagaaattat ttaaagttct       60

tagaccctat agtgagtcgt atta                                              84


<210>  166
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  166
atgggccatc atcatcatca tcatcatcat catcacacta cagtaaaaaa aaacagagcg       60


<210>  167
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  167
ggtggtaaat ttg                                                          13


<210>  168
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  168
gtcagtcaga ag                                                           12


<210>  169
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  169
ggtttataag ctaaatggtg aggc                                              24


<210>  170
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  170
gtcgcgaacg ccagcaag                                                     18


<210>  171
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  171
atgcagaagc ttttgacagc tagctcagtc ctaggtataa tgctagcgtc taagaacttt       60

aaataatttc tactgttgta gattgcacct tgaagcgcat gaagggcttg atgtctaaga      120

actttaaata atttgtctgt atattattga tttctaaatt agaattttcg gccgatgcag      180


