SEQUENCE LISTING

<110>   ProQR Therapeutics II B.V.

<120>   ALZHEIMERS DISEASE

<130>   P067431WO

<140>   n/a
<141>   2016-10-14

<150>   GB 1518349.4
<151>   2015-10-16

<150>   GB 1614863.7
<151>   2016-09-01

<160>   60

<170>   SeqWin2010, version 1.0

<210>   1
<211>   251
<212>   RNA
<213>   intron 16 - exon 17 - intron 17 

<400>   1
auuauauugc auuuagaaau uaaaauucuu uuucuuaauu uguuuucaag guguucuuug  60
cagaagaugu ggguucaaac aaaggugcaa ucauuggacu cauggugggc gguguuguca  120
uagcgacagu gaucgucauc accuugguga ugcugaagaa gaaacaguac acauccauuc  180
aucauggugu gguggaggua gguaaacuug acugcauguu uccaaguggg aauuaagacu  240
augagagaau u                                                       251

<210>   2
<211>   14
<212>   PRT
<213>   C-terminal portion of the A peptide

<400>   2
Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
1               5                   10                  

<210>   3
<211>   147
<212>   RNA
<213>   Exon 17 

<400>   3
guguucuuug cagaagaugu ggguucaaac aaaggugcaa ucauuggacu cauggugggc  60
gguguuguca uagcgacagu gaucgucauc accuugguga ugcugaagaa gaaacaguac  120
acauccauuc aucauggugu gguggag                                      147

<210>   4
<211>   646
<212>   PRT
<213>   APP646

<400>   4
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      

Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          

Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              

Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  

Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  

Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      

Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         

Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             

Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 

Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 

Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     

Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         

Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             

Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 

Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 

Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     

Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         

Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             

Val Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu 
    290                 295                 300                 

Glu Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln Lys Ala Lys 
305                 310                 315                 320 

Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln Val Met Arg 
                325                 330                 335     

Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp 
            340                 345                 350         

Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu 
        355                 360                 365             

Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Thr His Met Ala 
    370                 375                 380                 

Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn 
385                 390                 395                 400 

Tyr Ile Thr Ala Leu Gln Ala Val Pro Pro Arg Pro Arg His Val Phe 
                405                 410                 415     

Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His 
            420                 425                 430         

Thr Leu Lys His Phe Glu His Val Arg Met Val Asp Pro Lys Lys Ala 
        435                 440                 445             

Ala Gln Ile Arg Ser Gln Val Met Thr His Leu Arg Val Ile Tyr Glu 
    450                 455                 460                 

Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala 
465                 470                 475                 480 

Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn 
                485                 490                 495     

Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser 
            500                 505                 510         

Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr 
        515                 520                 525             

Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln 
    530                 535                 540                 

Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn 
545                 550                 555                 560 

Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr 
                565                 570                 575     

Thr Arg Pro Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser 
            580                 585                 590         

Glu Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val 
        595                 600                 605             

His His Gln Lys Leu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His 
    610                 615                 620                 

Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe 
625                 630                 635                 640 

Phe Glu Gln Met Gln Asn 
                645     

<210>   5
<211>   695
<212>   PRT
<213>   APP695

<400>   5
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      

Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          

Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              

Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  

Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  

Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      

Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         

Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             

Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 

Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 

Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     

Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         

Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             

Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 

Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 

Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     

Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         

Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             

Val Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu 
    290                 295                 300                 

Glu Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln Lys Ala Lys 
305                 310                 315                 320 

Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln Val Met Arg 
                325                 330                 335     

Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp 
            340                 345                 350         

Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu 
        355                 360                 365             

Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Thr His Met Ala 
    370                 375                 380                 

Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn 
385                 390                 395                 400 

Tyr Ile Thr Ala Leu Gln Ala Val Pro Pro Arg Pro Arg His Val Phe 
                405                 410                 415     

Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His 
            420                 425                 430         

Thr Leu Lys His Phe Glu His Val Arg Met Val Asp Pro Lys Lys Ala 
        435                 440                 445             

Ala Gln Ile Arg Ser Gln Val Met Thr His Leu Arg Val Ile Tyr Glu 
    450                 455                 460                 

Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala 
465                 470                 475                 480 

Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn 
                485                 490                 495     

Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser 
            500                 505                 510         

Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr 
        515                 520                 525             

Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln 
    530                 535                 540                 

Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn 
545                 550                 555                 560 

Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr 
                565                 570                 575     

Thr Arg Pro Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser 
            580                 585                 590         

Glu Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val 
        595                 600                 605             

His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys 
    610                 615                 620                 

Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val 
625                 630                 635                 640 

Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile 
                645                 650                 655     

His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg 
            660                 665                 670         

His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys 
        675                 680                 685             

Phe Phe Glu Gln Met Gln Asn 
    690                 695 

<210>   6
<211>   49
<212>   PRT
<213>   Skipped sequence (aa.608-656 of SEQ ID NO: 5)

<400>   6
Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
1               5                   10                  15      

Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
            20                  25                  30          

Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
        35                  40                  45              

Glu 
    

<210>   7
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Forward primer

<400>   7
tccgacatga ctcaggatat ga                                           22

<210>   8
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Reverse primer

<400>   8
tagccgttct gctgcatctt                                              20

<210>   9
<211>   22
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON1

<400>   9
uucugcaaag aacaccuuga aa                                           22

<210>   10
<211>   22
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON2

<400>   10
accuuucuuu gaacccacau cu                                           22

<210>   11
<211>   24
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON3

<400>   11
aaugauugca ccuuuguuug aacc                                         24

<210>   12
<211>   21
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON4

<400>   12
cgcccaccau gaguccaaug a                                            21

<210>   13
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON5

<400>   13
acugucgcua ugacaacacc                                              20

<210>   14
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON6

<400>   14
uguacuguuu cuucuucagc                                              20

<210>   15
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON7

<400>   15
gaugaaugga uguguacugu                                              20

<210>   16
<211>   22
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON8

<400>   16
ucaaguuuac cuaccuccac ca                                           22

<210>   17
<211>   24
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON1-1

<400>   17
gaacaccuug aaaacaaauu aaga                                         24

<210>   18
<211>   25
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON1-2

<400>   18
acaucuucug caaagaacac cuuga                                        25

<210>   19
<211>   25
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON1-3

<400>   19
uucugcaaag aacaccuuga aaaca                                        25

<210>   20
<211>   31
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide AON1-4

<400>   20
aucuucugca aagcaacacc uugaaaacaa a                                 31

<210>   21
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   hAPPEx16_1 (LUMC1)

<400>   21
accaugaguc caaugauugc                                              20

<210>   22
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   hAPPEx16_2 (LUMC2)

<400>   22
ucaccaaggu gaugacgauc                                              20

<210>   23
<211>   23
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   hAPPEx16_3 (LUMC3)

<400>   23
caccaugaug aauggaugug uac                                          23

<210>   24
<211>   21
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   hAPPEx16_4 (LUMC4)

<400>   24
guuugaaccc acaucuucug c                                            21

<210>   25
<211>   22
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   hAPPEx16_5 (LUMC5)

<400>   25
cuguuucuuc uucagcauca cc                                           22

<210>   26
<211>   23
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   hAPPEx16_6 (LUMC6)

<400>   26
cuaccuccac cacaccauga uga                                          23

<210>   27
<211>   42
<212>   Combined DNA/RNA
<213>   Artificial Sequence

<220>
<223>   OL-1 DNA mouse

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<400>   27
ggcgcctttg ttcgaaccca caucttcagc aaagaacacc ag                     42

<210>   28
<211>   42
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   OL-1 RNA mouse

<400>   28
ggcgccuuug uucgaaccca caucuucagc aaagaacacc ag                     42

<210>   29
<211>   42
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   OL-1 hRNA / HOL1-RNA

<400>   29
ugcaccuuug uuugaaccca caucuucugc aaagaacacc uu                     42

<210>   30
<211>   14
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   OL-3

<400>   30
aacccacauc uuca                                                    14

<210>   31
<211>   57
<212>   RNA
<213>   Part of exon 17 of the human APP gene

<400>   31
ucuuaauuug uuuucaaggu guucuuugca gaagaugugg guucaaacaa aggugca     57

<210>   32
<211>   15
<212>   RNA
<213>   Part of exon 17 of the human APP gene

<400>   32
guguucuuug cagaa                                                   15

<210>   33
<211>   16
<212>   RNA
<213>   Part of exon 17 of the human APP gene

<400>   33
guguucuuug cagaag                                                  16

<210>   34
<211>   17
<212>   RNA
<213>   Part of exon 17 of the human APP gene

<400>   34
guguucuuug cagaaga                                                 17

<210>   35
<211>   18
<212>   RNA
<213>   Part of exon 17 of the human APP gene

<400>   35
guguucuuug cagaagau                                                18

<210>   36
<211>   36
<212>   RNA
<213>   Part of intron16/exon17 of the human APP gene

<400>   36
ucuuaauuug uuuucaaggu guucuuugca gaagau                            36

<210>   37
<211>   39
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203h (39)

<400>   37
accuuuguuu gaacccacau cuucugcaaa gaacaccuu                         39

<210>   38
<211>   36
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203h (36)

<400>   38
uuuguuugaa cccacaucuu cugcaaagaa caccuu                            36

<210>   39
<211>   33
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203h (33)

<400>   39
guuugaaccc acaucuucug caaagaacac cuu                               33

<210>   40
<211>   30
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203h (30)

<400>   40
ugaacccaca ucuucugcaa agaacaccuu                                   30

<210>   41
<211>   27
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203h (27)

<400>   41
acccacaucu ucugcaaaga acaccuu                                      27

<210>   42
<211>   39
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203m (39) 

<400>   42
gccuuuguuc gaacccacau cuucagcaaa gaacaccuu                         39

<210>   43
<211>   36
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203m (36) 

<400>   43
uuuguucgaa cccacaucuu cagcaaagaa caccuu                            36

<210>   44
<211>   33
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203m (33) 

<400>   44
guucgaaccc acaucuucag caaagaacac cuu                               33

<210>   45
<211>   30
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203m (30) 

<400>   45
cgaacccaca ucuucagcaa agaacaccuu                                   30

<210>   46
<211>   27
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   QRX-203m (27) 

<400>   46
acccacaucu ucagcaaaga acaccuu                                      27

<210>   47
<211>   26
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   AON1-2-1

<400>   47
ccacaucuuc ugcaaagaac accuug                                       26

<210>   48
<211>   30
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   AON1-4-1

<400>   48
aucuucugca aagaacaccu ugaaaacaaa                                   30

<210>   49
<211>   34
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   AON1-4-2

<400>   49
ccacaucuuc ugcaaagaac accuugaaaa caaa                              34

<210>   50
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Forward primer

<400>   50
tctgggctga caaacatcaa                                              20

<210>   51
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Reverse primer

<400>   51
ttctgctgca tcttggagag                                              20

<210>   52
<211>   75
<212>   PRT
<213>   Exon 16 - Exon 17 - Exon 18 of APP

<400>   52
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      

Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          

Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              

Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val 
    50                  55                  60                  

Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu 
65                  70                  75  

<210>   53
<211>   26
<212>   PRT
<213>   Exon 16 - Exon 18 of APP

<400>   53
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      

Leu Val Asp Ala Ala Val Thr Pro Glu Glu 
            20                  25      

<210>   54
<211>   14
<212>   PRT
<213>   APP

<400>   54
Thr Glu Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe Arg 
1               5                   10                  

<210>   55
<211>   5
<212>   PRT
<213>   APP

<400>   55
His Gly Lys Leu Val 
1               5   

<210>   56
<211>   5
<212>   PRT
<213>   APP

<400>   56
Val Gly Ser Asn Lys 
1               5   

<210>   57
<211>   15
<212>   PRT
<213>   APP

<400>   57
Thr Val Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln Tyr 
1               5                   10                  15  

<210>   58
<211>   5
<212>   PRT
<213>   APP

<400>   58
Glu Gln Met Gln Asn 
1               5   

<210>   59
<211>   34
<212>   PRT
<213>   APP

<400>   59
Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val 
1               5                   10                  15      

Val Ile Ala Thr Val Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys 
            20                  25                  30          

Gln Tyr 
        

<210>   60
<211>   199
<212>   RNA
<213>   exon 17 of human APP and flanking regions

<400>   60
cuuuuucuua auuuguuuuc aagguguucu uugcagaaga uguggguuca aacaaaggug  60
caaucauugg acucauggug ggcgguguug ucauagcgac agugaucguc aucaccuugg  120
ugaugcugaa gaagaaacag uacacaucca uucaucaugg ugugguggag guagguaaac  180
uugacugcau guuuccaag                                               199

