                         SEQUENCE LISTING

<110>  Affimed GmbH
 
<120>  Novel Multivalent Fv Antibodies

<130>  A 3305PCT

<150>  EP 15189665.1
<151>  2015-10-13

<160>  40 

<170>  PatentIn version 3.5

<210>  1
<211>  780
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            260                 265                 270         


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
        275                 280                 285             


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    290                 295                 300                 


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
305                 310                 315                 320 


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
                325                 330                 335     


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
385                 390                 395                 400 


Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                405                 410                 415     


Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            420                 425                 430         


Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln 
        435                 440                 445             


Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr 
    450                 455                 460                 


Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp 
                485                 490                 495     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala 
        515                 520                 525             


Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser 
    530                 535                 540                 


Lys Thr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
545                 550                 555                 560 


Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe 
                565                 570                 575     


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val 
            580                 585                 590         


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr Asp Trp 
        595                 600                 605             


Ser Asp His Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
                645                 650                 655     


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
            660                 665                 670         


Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
        675                 680                 685             


Gly Leu Glu Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp Thr Met 
    690                 695                 700                 


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Glu Ser 
705                 710                 715                 720 


Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
                725                 730                 735     


Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr 
            740                 745                 750         


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        755                 760                 765             


Ser Ala Ala Ala Gly Ser His His His His His His 
    770                 775                 780 


<210>  2
<211>  234
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  2

Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala 
        115                 120                 125             


Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser 
    130                 135                 140                 


Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu 
145                 150                 155                 160 


Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe 
                165                 170                 175     


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr 
            180                 185                 190         


Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr 
        195                 200                 205             


Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala 
    210                 215                 220                 


Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
225                 230                 


<210>  3
<211>  780
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  3

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Thr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr Asp Trp Ser Asp His 
                85                  90                  95      


Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
    130                 135                 140                 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
145                 150                 155                 160 


Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp Thr Met Tyr Ser Pro 
            180                 185                 190         


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Glu Ser Ile Asn Thr 
        195                 200                 205             


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala 
225                 230                 235                 240 


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
            260                 265                 270         


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser 
        275                 280                 285             


Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro 
    290                 295                 300                 


Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser 
305                 310                 315                 320 


Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp 
                325                 330                 335     


Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
            340                 345                 350         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp 
        355                 360                 365             


Phe Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
385                 390                 395                 400 


Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala 
                405                 410                 415     


Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala 
            420                 425                 430         


Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly 
        435                 440                 445             


Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
    450                 455                 460                 


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
465                 470                 475                 480 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr 
                485                 490                 495     


Asp Phe Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
        515                 520                 525             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    530                 535                 540                 


Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val Arg Gln 
545                 550                 555                 560 


Arg Pro Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser 
                565                 570                 575     


Gly Tyr Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr 
            580                 585                 590         


Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr 
        595                 600                 605             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly 
    610                 615                 620                 


Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val 
625                 630                 635                 640 


Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                645                 650                 655     


Gly Gly Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Lys Phe 
            660                 665                 670         


Met Ser Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys Lys Ala Ser 
        675                 680                 685             


Gln Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln 
    690                 695                 700                 


Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val 
705                 710                 715                 720 


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                725                 730                 735     


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln 
            740                 745                 750         


Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        755                 760                 765             


Asn Ala Ala Ala Gly Ser His His His His His His 
    770                 775                 780 


<210>  4
<211>  234
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  4

Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala 
        115                 120                 125             


Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser 
    130                 135                 140                 


Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu 
145                 150                 155                 160 


Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe 
                165                 170                 175     


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr 
            180                 185                 190         


Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr 
        195                 200                 205             


Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala 
    210                 215                 220                 


Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
225                 230                 


<210>  5
<211>  752
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  5

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Thr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr Asp Trp Ser Asp His 
                85                  90                  95      


Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
    130                 135                 140                 


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
145                 150                 155                 160 


Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp Thr Met Tyr Ser Pro 
            180                 185                 190         


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Glu Ser Ile Asn Thr 
        195                 200                 205             


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala 
225                 230                 235                 240 


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser 
            260                 265                 270         


Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His 
        275                 280                 285             


Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln 
    290                 295                 300                 


Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile 
305                 310                 315                 320 


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
                325                 330                 335     


Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val 
            340                 345                 350         


Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val 
        355                 360                 365             


Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln 
    370                 375                 380                 


Pro Ser Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys 
385                 390                 395                 400 


Gly Gly His Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg 
                405                 410                 415     


Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro 
            420                 425                 430         


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 
        435                 440                 445             


Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr 
    450                 455                 460                 


Cys Gln Val Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys 
465                 470                 475                 480 


Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln 
                485                 490                 495     


Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys 
            500                 505                 510         


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His 
        515                 520                 525             


Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile Gly Tyr Ile 
    530                 535                 540                 


Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys 
545                 550                 555                 560 


Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu 
                565                 570                 575     


Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg 
            580                 585                 590         


Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val Met Thr Gln 
625                 630                 635                 640 


Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Thr Val Thr 
                645                 650                 655     


Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln 
            660                 665                 670         


Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg 
        675                 680                 685             


Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
    690                 695                 700                 


Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr 
705                 710                 715                 720 


Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
                725                 730                 735     


Lys Leu Glu Ile Asn Ala Ala Ala Gly Ser His His His His His His 
            740                 745                 750         


<210>  6
<211>  262
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
            180                 185                 190         


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
        195                 200                 205             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser Asp Tyr 
                245                 250                 255     


Lys Asp Asp Asp Asp Lys 
            260         


<210>  7
<211>  754
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly 
            260                 265                 270         


Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn 
        275                 280                 285             


Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile 
    290                 295                 300                 


Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
305                 310                 315                 320 


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala 
                325                 330                 335     


Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val 
            340                 345                 350         


Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
    370                 375                 380                 


Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly 
385                 390                 395                 400 


Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val 
                405                 410                 415     


Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg 
            420                 425                 430         


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
        435                 440                 445             


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn 
    450                 455                 460                 


Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser 
                485                 490                 495     


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn 
            500                 505                 510         


Asn Ile Gly Ser Lys Thr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
        515                 520                 525             


Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile 
    530                 535                 540                 


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
545                 550                 555                 560 


Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val 
                565                 570                 575     


Gly Thr Asp Trp Ser Asp His Leu Gln Val Phe Gly Gly Gly Thr Lys 
            580                 585                 590         


Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        595                 600                 605             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser 
    610                 615                 620                 


Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys 
625                 630                 635                 640 


Gly Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln 
                645                 650                 655     


Met Pro Gly Lys Gly Leu Glu Trp Met Gly Met Ile Trp Pro Gly Asp 
            660                 665                 670         


Ser Asp Thr Met Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser 
        675                 680                 685             


Ala Asp Glu Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys 
    690                 695                 700                 


Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr Thr 
705                 710                 715                 720 


Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                725                 730                 735     


Val Thr Val Ser Ser Ala Ala Ala Gly Ser Asp Tyr Lys Asp Asp Asp 
            740                 745                 750         


Asp Lys 
        


<210>  8
<211>  260
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
            180                 185                 190         


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
        195                 200                 205             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser His His 
                245                 250                 255     


His His His His 
            260 


<210>  9
<211>  494
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly 
            100                 105                 110         


Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
        115                 120                 125             


Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
    130                 135                 140                 


Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
145                 150                 155                 160 


Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr 
                165                 170                 175     


Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr 
            180                 185                 190         


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
        195                 200                 205             


Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
                245                 250                 255     


Lys Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr 
            260                 265                 270         


Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln 
        275                 280                 285             


Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser 
    290                 295                 300                 


Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
305                 310                 315                 320 


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala 
            340                 345                 350         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
        355                 360                 365             


Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val 
    370                 375                 380                 


Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn 
385                 390                 395                 400 


Ile Gly Ser Lys Thr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                405                 410                 415     


Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro 
            420                 425                 430         


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
        435                 440                 445             


Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly 
    450                 455                 460                 


Thr Asp Trp Ser Asp His Leu Gln Val Phe Gly Gly Gly Thr Lys Leu 
465                 470                 475                 480 


Thr Val Leu Ala Ala Ala Gly Ser His His His His His His 
                485                 490                 


<210>  10
<211>  499
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  10

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Trp Pro Gly Asp Ser Asp Thr Met Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Glu Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser 
    130                 135                 140                 


Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile 
145                 150                 155                 160 


Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro 
                165                 170                 175     


Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu 
            180                 185                 190         


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
        195                 200                 205             


Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
    210                 215                 220                 


Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser 
                245                 250                 255     


Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly 
            260                 265                 270         


His Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly 
        275                 280                 285             


Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly 
    290                 295                 300                 


Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 
305                 310                 315                 320 


Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln 
                325                 330                 335     


Val Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr 
            340                 345                 350         


Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln 
        355                 360                 365             


Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser 
    370                 375                 380                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val 
385                 390                 395                 400 


Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro 
                405                 410                 415     


Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr 
            420                 425                 430         


Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser 
        435                 440                 445             


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp 
    450                 455                 460                 


Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
465                 470                 475                 480 


Thr Val Thr Val Ser Ser Ala Ala Ala Gly Ser Asp Tyr Lys Asp Asp 
                485                 490                 495     


Asp Asp Lys 
            


<210>  11
<211>  1019
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fv polypeptide

<400>  11

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            260                 265                 270         


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
        275                 280                 285             


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    290                 295                 300                 


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
305                 310                 315                 320 


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
                325                 330                 335     


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
385                 390                 395                 400 


Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                405                 410                 415     


Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            420                 425                 430         


Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln 
        435                 440                 445             


Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr 
    450                 455                 460                 


Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp 
                485                 490                 495     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu 
        515                 520                 525             


Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile 
    530                 535                 540                 


Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln 
545                 550                 555                 560 


Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys 
                565                 570                 575     


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
            580                 585                 590         


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp 
        595                 600                 605             


Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly 
    610                 615                 620                 


Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser 
625                 630                 635                 640 


Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln Thr 
                645                 650                 655     


Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val His 
            660                 665                 670         


Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln 
        675                 680                 685             


Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    690                 695                 700                 


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp 
705                 710                 715                 720 


Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly 
            740                 745                 750         


Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
        755                 760                 765             


Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys 
    770                 775                 780                 


Thr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
785                 790                 795                 800 


Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
                805                 810                 815     


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu 
            820                 825                 830         


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr Asp Trp Ser 
        835                 840                 845             


Asp His Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
    850                 855                 860                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
865                 870                 875                 880 


Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
                885                 890                 895     


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
            900                 905                 910         


Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
        915                 920                 925             


Leu Glu Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp Thr Met Tyr 
    930                 935                 940                 


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Glu Ser Ile 
945                 950                 955                 960 


Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
                965                 970                 975     


Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr 
            980                 985                 990         


Tyr Ala Met Asp Tyr Trp Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser 
        995                 1000                 1005             


Ala Ala  Ala Gly Ser His His  His His His His 
    1010                 1015                 


<210>  12
<211>  749
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  12

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly 
            260                 265                 270         


Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn 
        275                 280                 285             


Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile 
    290                 295                 300                 


Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
305                 310                 315                 320 


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala 
                325                 330                 335     


Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val 
            340                 345                 350         


Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
    370                 375                 380                 


Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly 
385                 390                 395                 400 


Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val 
                405                 410                 415     


Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg 
            420                 425                 430         


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
        435                 440                 445             


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn 
    450                 455                 460                 


Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
                485                 490                 495     


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
            500                 505                 510         


Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro 
        515                 520                 525             


Gly Lys Gly Leu Glu Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp 
    530                 535                 540                 


Thr Met Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
545                 550                 555                 560 


Glu Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
                565                 570                 575     


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly 
            580                 585                 590         


Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        595                 600                 605             


Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    610                 615                 620                 


Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser 
625                 630                 635                 640 


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
                645                 650                 655     


Gly Ser Lys Thr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            660                 665                 670         


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
        675                 680                 685             


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
    690                 695                 700                 


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr 
705                 710                 715                 720 


Asp Trp Ser Asp His Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
                725                 730                 735     


Val Leu Ala Ala Ala Gly Ser His His His His His His 
            740                 745                 


<210>  13
<211>  262
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
            180                 185                 190         


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
        195                 200                 205             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser Asp Tyr 
                245                 250                 255     


Lys Asp Asp Asp Asp Lys 
            260         


<210>  14
<211>  749
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  14
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly 
            260                 265                 270         


Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn 
        275                 280                 285             


Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile 
    290                 295                 300                 


Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
305                 310                 315                 320 


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala 
                325                 330                 335     


Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val 
            340                 345                 350         


Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
    370                 375                 380                 


Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly 
385                 390                 395                 400 


Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val 
                405                 410                 415     


Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg 
            420                 425                 430         


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
        435                 440                 445             


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn 
    450                 455                 460                 


Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
                485                 490                 495     


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
            500                 505                 510         


Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro 
        515                 520                 525             


Gly Lys Gly Leu Glu Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp 
    530                 535                 540                 


Thr Met Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
545                 550                 555                 560 


Glu Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
                565                 570                 575     


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly 
            580                 585                 590         


Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        595                 600                 605             


Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    610                 615                 620                 


Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser 
625                 630                 635                 640 


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
                645                 650                 655     


Gly Ser Lys Thr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            660                 665                 670         


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
        675                 680                 685             


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
    690                 695                 700                 


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr 
705                 710                 715                 720 


Asp Trp Ser Asp His Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
                725                 730                 735     


Val Leu Ala Ala Ala Gly Ser His His His His His His 
            740                 745                 


<210>  15
<211>  522
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
            180                 185                 190         


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
        195                 200                 205             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
                245                 250                 255     


Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro 
            260                 265                 270         


Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln 
        275                 280                 285             


Tyr Ala Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val 
    290                 295                 300                 


Ile Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
305                 310                 315                 320 


Gly Ser Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln 
                325                 330                 335     


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly 
            340                 345                 350         


Thr Pro Leu Ile Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
385                 390                 395                 400 


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
                405                 410                 415     


Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
            420                 425                 430         


Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
        435                 440                 445             


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
    450                 455                 460                 


Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala 
465                 470                 475                 480 


Met Tyr Tyr Cys Ala Arg Leu Gly Ser Ser Trp Thr Asn Asp Ala Phe 
                485                 490                 495     


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ala Ala 
            500                 505                 510         


Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
        515                 520         


<210>  16
<211>  1264
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser 
    130                 135                 140                 


Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln Asn 
145                 150                 155                 160 


Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
                165                 170                 175     


Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp 
            180                 185                 190         


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His 
    210                 215                 220                 


Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala 
            260                 265                 270         


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        275                 280                 285             


Phe Thr Thr Tyr Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp 
    290                 295                 300                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr 
305                 310                 315                 320 


Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser 
                325                 330                 335     


Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr 
        355                 360                 365             


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
385                 390                 395                 400 


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys Lys 
                405                 410                 415     


Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
        435                 440                 445             


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys 
465                 470                 475                 480 


Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu 
                485                 490                 495     


Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu 
            500                 505                 510         


Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile 
        515                 520                 525             


Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln 
    530                 535                 540                 


Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys 
545                 550                 555                 560 


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
                565                 570                 575     


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp 
            580                 585                 590         


Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly 
        595                 600                 605             


Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser 
    610                 615                 620                 


Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln Thr 
625                 630                 635                 640 


Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val His 
                645                 650                 655     


Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln 
            660                 665                 670         


Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
        675                 680                 685             


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp 
    690                 695                 700                 


Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu Phe 
705                 710                 715                 720 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly 
                725                 730                 735     


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            740                 745                 750         


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
        755                 760                 765             


Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
    770                 775                 780                 


Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp Thr Met Tyr Ser Pro 
785                 790                 795                 800 


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Glu Ser Ile Asn Thr 
                805                 810                 815     


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
            820                 825                 830         


Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala 
        835                 840                 845             


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    850                 855                 860                 


Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser 
865                 870                 875                 880 


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn 
                885                 890                 895     


Asn Ile Gly Ser Lys Thr Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
            900                 905                 910         


Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile 
        915                 920                 925             


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
    930                 935                 940                 


Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val 
945                 950                 955                 960 


Gly Thr Asp Trp Ser Asp His Leu Gln Val Phe Gly Gly Gly Thr Lys 
                965                 970                 975     


Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            980                 985                 990         


Gly Gly Ser Gly Gly Ser Gly Gly  Ser Glu Val Gln Leu  Val Gln Ser 
        995                 1000                 1005             


Gly Ala  Glu Val Lys Lys Pro  Gly Glu Ser Leu Lys  Ile Ser Cys 
    1010                 1015                 1020             


Lys Gly  Ser Gly Tyr Ser Phe  Thr Ser Asn Trp Ile  Gly Trp Val 
    1025                 1030                 1035             


Arg Gln  Met Pro Gly Lys Gly  Leu Glu Trp Met Gly  Met Ile Trp 
    1040                 1045                 1050             


Pro Gly  Asp Ser Asp Thr Met  Tyr Ser Pro Ser Phe  Gln Gly Gln 
    1055                 1060                 1065             


Val Thr  Ile Ser Ala Asp Glu  Ser Ile Asn Thr Ala  Tyr Leu Gln 
    1070                 1075                 1080             


Trp Ser  Ser Leu Lys Ala Ser  Asp Thr Ala Met Tyr  Tyr Cys Ala 
    1085                 1090                 1095             


Arg Arg  Glu Thr Thr Thr Val  Gly Arg Tyr Tyr Tyr  Ala Met Asp 
    1100                 1105                 1110             


Tyr Trp  Gly Gln Gly Thr Leu  Val Thr Val Ser Ser  Gly Gly Ser 
    1115                 1120                 1125             


Gly Gly  Ser Gly Gly Ser Ser  Tyr Val Leu Thr Gln  Pro Pro Ser 
    1130                 1135                 1140             


Val Ser  Val Ala Pro Gly Gln  Thr Ala Arg Ile Thr  Cys Gly Gly 
    1145                 1150                 1155             


Asn Asn  Ile Gly Ser Lys Thr  Val His Trp Tyr Gln  Gln Lys Pro 
    1160                 1165                 1170             


Gly Gln  Ala Pro Val Leu Val  Val Tyr Asp Asp Ser  Asp Arg Pro 
    1175                 1180                 1185             


Ser Gly  Ile Pro Glu Arg Phe  Ser Gly Ser Asn Ser  Gly Asn Thr 
    1190                 1195                 1200             


Ala Thr  Leu Thr Ile Ser Arg  Val Glu Ala Gly Asp  Glu Ala Asp 
    1205                 1210                 1215             


Tyr Tyr  Cys Gln Val Gly Thr  Asp Trp Ser Asp His  Leu Gln Val 
    1220                 1225                 1230             


Phe Gly  Gly Gly Thr Lys Leu  Thr Val Leu Ala Ala  Ala Gly Ser 
    1235                 1240                 1245             


His His  His His His His Ala  Arg Thr Ile Phe Ile  Cys Ile Ala 
    1250                 1255                 1260             


Leu 
    


<210>  17
<211>  262
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
            180                 185                 190         


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
        195                 200                 205             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser Asp Tyr 
                245                 250                 255     


Lys Asp Asp Asp Asp Lys 
            260         


<210>  18
<211>  749
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  18

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly 
            260                 265                 270         


Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn 
        275                 280                 285             


Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile 
    290                 295                 300                 


Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
305                 310                 315                 320 


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala 
                325                 330                 335     


Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val 
            340                 345                 350         


Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
    370                 375                 380                 


Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly 
385                 390                 395                 400 


Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val 
                405                 410                 415     


Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg 
            420                 425                 430         


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
        435                 440                 445             


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn 
    450                 455                 460                 


Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
                485                 490                 495     


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
            500                 505                 510         


Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro 
        515                 520                 525             


Gly Lys Gly Leu Glu Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp 
    530                 535                 540                 


Thr Met Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
545                 550                 555                 560 


Glu Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
                565                 570                 575     


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly 
            580                 585                 590         


Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        595                 600                 605             


Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    610                 615                 620                 


Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser 
625                 630                 635                 640 


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
                645                 650                 655     


Gly Ser Lys Thr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            660                 665                 670         


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
        675                 680                 685             


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
    690                 695                 700                 


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr 
705                 710                 715                 720 


Asp Trp Ser Asp His Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
                725                 730                 735     


Val Leu Ala Ala Ala Gly Ser His His His His His His 
            740                 745                 


<210>  19
<211>  778
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            260                 265                 270         


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
        275                 280                 285             


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    290                 295                 300                 


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
305                 310                 315                 320 


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
                325                 330                 335     


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
385                 390                 395                 400 


Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                405                 410                 415     


Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            420                 425                 430         


Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln 
        435                 440                 445             


Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr 
    450                 455                 460                 


Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp 
                485                 490                 495     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser 
        515                 520                 525             


Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys 
    530                 535                 540                 


Gln Tyr Ala Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
545                 550                 555                 560 


Val Ile Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe 
                565                 570                 575     


Ser Gly Ser Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val 
            580                 585                 590         


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser 
        595                 600                 605             


Gly Thr Pro Leu Ile Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
                645                 650                 655     


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
            660                 665                 670         


Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
        675                 680                 685             


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
    690                 695                 700                 


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
705                 710                 715                 720 


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
                725                 730                 735     


Ala Met Tyr Tyr Cys Ala Arg Leu Gly Ser Ser Trp Thr Asn Asp Ala 
            740                 745                 750         


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ala 
        755                 760                 765             


Ala Gly Ser Asp Tyr Lys Asp Asp Asp Asp 
    770                 775             


<210>  20
<211>  749
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  20

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly 
            260                 265                 270         


Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn 
        275                 280                 285             


Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile 
    290                 295                 300                 


Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
305                 310                 315                 320 


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala 
                325                 330                 335     


Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val 
            340                 345                 350         


Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
    370                 375                 380                 


Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly 
385                 390                 395                 400 


Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val 
                405                 410                 415     


Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg 
            420                 425                 430         


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
        435                 440                 445             


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn 
    450                 455                 460                 


Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
                485                 490                 495     


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
            500                 505                 510         


Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro 
        515                 520                 525             


Gly Lys Gly Leu Glu Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp 
    530                 535                 540                 


Thr Met Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
545                 550                 555                 560 


Glu Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
                565                 570                 575     


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly 
            580                 585                 590         


Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        595                 600                 605             


Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    610                 615                 620                 


Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser 
625                 630                 635                 640 


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
                645                 650                 655     


Gly Ser Lys Thr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            660                 665                 670         


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
        675                 680                 685             


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
    690                 695                 700                 


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr 
705                 710                 715                 720 


Asp Trp Ser Asp His Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr 
                725                 730                 735     


Val Leu Ala Ala Ala Gly Ser His His His His His His 
            740                 745                 


<210>  21
<211>  519
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            260                 265                 270         


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
        275                 280                 285             


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    290                 295                 300                 


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
305                 310                 315                 320 


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
                325                 330                 335     


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
385                 390                 395                 400 


Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                405                 410                 415     


Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            420                 425                 430         


Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln 
        435                 440                 445             


Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr 
    450                 455                 460                 


Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp 
                485                 490                 495     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser Asp 
            500                 505                 510         


Tyr Lys Asp Asp Asp Asp Lys 
        515                 


<210>  22
<211>  497
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
    130                 135                 140                 


Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly 
145                 150                 155                 160 


Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg 
            180                 185                 190         


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
        195                 200                 205             


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn 
    210                 215                 220                 


Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser 
                245                 250                 255     


Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His 
            260                 265                 270         


Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln 
        275                 280                 285             


Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile 
    290                 295                 300                 


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
305                 310                 315                 320 


Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val 
                325                 330                 335     


Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val 
            340                 345                 350         


Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln 
        355                 360                 365             


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
    370                 375                 380                 


Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg 
385                 390                 395                 400 


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Met Ile Trp Pro Gly 
                405                 410                 415     


Asp Ser Asp Thr Met Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile 
            420                 425                 430         


Ser Ala Asp Glu Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu 
        435                 440                 445             


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr 
    450                 455                 460                 


Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
465                 470                 475                 480 


Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser His His His His His 
                485                 490                 495     


His 
    


<210>  23
<211>  493
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  23

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Thr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr Asp Trp Ser Asp His 
                85                  90                  95      


Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
                165                 170                 175     


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr 
    210                 215                 220                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
                245                 250                 255     


Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
            260                 265                 270         


Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
        275                 280                 285             


Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr 
    290                 295                 300                 


Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr 
305                 310                 315                 320 


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
                325                 330                 335     


Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met 
    370                 375                 380                 


Ser Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln 
385                 390                 395                 400 


Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser 
                405                 410                 415     


Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
            420                 425                 430         


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        435                 440                 445             


Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr 
    450                 455                 460                 


His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn 
465                 470                 475                 480 


Ala Ala Ala Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
                485                 490             


<210>  24
<211>  757
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  24

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
    130                 135                 140                 


Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly 
145                 150                 155                 160 


Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg 
            180                 185                 190         


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
        195                 200                 205             


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn 
    210                 215                 220                 


Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser 
                245                 250                 255     


Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His 
            260                 265                 270         


Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln 
        275                 280                 285             


Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile 
    290                 295                 300                 


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
305                 310                 315                 320 


Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val 
                325                 330                 335     


Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val 
            340                 345                 350         


Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln 
        355                 360                 365             


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
    370                 375                 380                 


Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg 
385                 390                 395                 400 


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Met Ile Trp Pro Gly 
                405                 410                 415     


Asp Ser Asp Thr Met Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile 
            420                 425                 430         


Ser Ala Asp Glu Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu 
        435                 440                 445             


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr Thr 
    450                 455                 460                 


Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
465                 470                 475                 480 


Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser 
                485                 490                 495     


Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr 
            500                 505                 510         


Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala Tyr 
        515                 520                 525             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
    530                 535                 540                 


Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Ser 
545                 550                 555                 560 


Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu Asp 
                565                 570                 575     


Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Pro Leu 
            580                 585                 590         


Ile Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly 
        595                 600                 605             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
625                 630                 635                 640 


Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser 
                645                 650                 655     


Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp 
            660                 665                 670         


Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser 
        675                 680                 685             


Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala 
    690                 695                 700                 


Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr 
705                 710                 715                 720 


Cys Ala Arg Leu Gly Ser Ser Trp Thr Asn Asp Ala Phe Asp Ile Trp 
                725                 730                 735     


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ala Ala Gly Ser His 
            740                 745                 750         


His His His His His 
        755         


<210>  25
<211>  753
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  25

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Thr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr Asp Trp Ser Asp His 
                85                  90                  95      


Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
                165                 170                 175     


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr 
    210                 215                 220                 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
                245                 250                 255     


Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
            260                 265                 270         


Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
        275                 280                 285             


Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr 
    290                 295                 300                 


Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr 
305                 310                 315                 320 


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
                325                 330                 335     


Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met 
    370                 375                 380                 


Ser Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln 
385                 390                 395                 400 


Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser 
                405                 410                 415     


Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
            420                 425                 430         


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        435                 440                 445             


Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr 
    450                 455                 460                 


His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro 
                485                 490                 495     


Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser 
            500                 505                 510         


Gly Asp Ala Leu Pro Lys Gln Tyr Ala Tyr Trp Tyr Gln Gln Lys Pro 
        515                 520                 525             


Gly Gln Ala Pro Val Leu Val Ile Tyr Lys Asp Ser Glu Arg Pro Ser 
    530                 535                 540                 


Gly Ile Pro Glu Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr Val Thr 
545                 550                 555                 560 


Leu Thr Ile Ser Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
                565                 570                 575     


Gln Ser Ala Asp Ser Ser Gly Thr Pro Leu Ile Val Phe Gly Thr Gly 
            580                 585                 590         


Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        595                 600                 605             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val 
    610                 615                 620                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser 
625                 630                 635                 640 


Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val 
                645                 650                 655     


Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro 
            660                 665                 670         


Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr 
        675                 680                 685             


Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser 
    690                 695                 700                 


Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Leu Gly Ser 
705                 710                 715                 720 


Ser Trp Thr Asn Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
                725                 730                 735     


Thr Val Ser Ser Ala Ala Ala Gly Ser Asp Tyr Lys Asp Asp Asp Asp 
            740                 745                 750         


Lys 
    


<210>  26
<211>  754
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ser Ser Trp Thr Asn Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Glu Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys Asp Ser Glu Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr 
        195                 200                 205             


Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Pro Leu Ile Val Phe Gly 
225                 230                 235                 240 


Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly 
            260                 265                 270         


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr 
        275                 280                 285             


Tyr Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp 
    290                 295                 300                 


Ile Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn 
305                 310                 315                 320 


Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala 
                325                 330                 335     


Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser 
385                 390                 395                 400 


Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile 
                405                 410                 415     


Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro 
            420                 425                 430         


Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu 
        435                 440                 445             


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
    450                 455                 460                 


Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
465                 470                 475                 480 


Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                485                 490                 495     


Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser 
            500                 505                 510         


Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly 
        515                 520                 525             


His Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly 
    530                 535                 540                 


Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly 
545                 550                 555                 560 


Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu 
                565                 570                 575     


Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln 
            580                 585                 590         


Val Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr 
        595                 600                 605             


Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val 
    610                 615                 620                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser 
625                 630                 635                 640 


Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val 
                645                 650                 655     


Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Met Ile Trp Pro 
            660                 665                 670         


Gly Asp Ser Asp Thr Met Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr 
        675                 680                 685             


Ile Ser Ala Asp Glu Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser 
    690                 695                 700                 


Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Glu Thr 
705                 710                 715                 720 


Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                725                 730                 735     


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser His His His His 
            740                 745                 750         


His His 
        


<210>  27
<211>  750
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  27

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ser Ser Trp Thr Asn Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Glu Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys Asp Ser Glu Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr 
        195                 200                 205             


Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Pro Leu Ile Val Phe Gly 
225                 230                 235                 240 


Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly 
            260                 265                 270         


Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Thr 
        275                 280                 285             


Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
    290                 295                 300                 


Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
305                 310                 315                 320 


Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala 
                325                 330                 335     


Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr Asp Trp Ser Asp 
            340                 345                 350         


His Leu Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    370                 375                 380                 


Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
385                 390                 395                 400 


Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
                405                 410                 415     


Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr 
            420                 425                 430         


Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr 
        435                 440                 445             


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    450                 455                 460                 


Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp 
465                 470                 475                 480 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly 
                485                 490                 495     


Gly Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            500                 505                 510         


Lys Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        515                 520                 525             


Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln 
    530                 535                 540                 


Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser 
545                 550                 555                 560 


Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
                565                 570                 575     


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            580                 585                 590         


Ala Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala 
        595                 600                 605             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Lys Phe 
625                 630                 635                 640 


Met Ser Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys Lys Ala Ser 
                645                 650                 655     


Gln Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln 
            660                 665                 670         


Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val 
        675                 680                 685             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    690                 695                 700                 


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln 
705                 710                 715                 720 


Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
                725                 730                 735     


Asn Ala Ala Ala Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
            740                 745                 750 


<210>  28
<211>  1016
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  28

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            260                 265                 270         


Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
        275                 280                 285             


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    290                 295                 300                 


Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys 
305                 310                 315                 320 


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val 
                325                 330                 335     


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
385                 390                 395                 400 


Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                405                 410                 415     


Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            420                 425                 430         


Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln 
        435                 440                 445             


Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr 
    450                 455                 460                 


Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp 
                485                 490                 495     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu 
        515                 520                 525             


Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile 
    530                 535                 540                 


Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln 
545                 550                 555                 560 


Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys 
                565                 570                 575     


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
            580                 585                 590         


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp 
        595                 600                 605             


Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly 
    610                 615                 620                 


Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser 
625                 630                 635                 640 


Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln Thr 
                645                 650                 655     


Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val His 
            660                 665                 670         


Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln 
        675                 680                 685             


Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    690                 695                 700                 


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp 
705                 710                 715                 720 


Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly 
            740                 745                 750         


Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
        755                 760                 765             


Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr 
    770                 775                 780                 


Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
785                 790                 795                 800 


Trp Met Gly Met Ile Trp Pro Gly Asp Ser Asp Thr Met Tyr Ser Pro 
                805                 810                 815     


Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Glu Ser Ile Asn Thr 
            820                 825                 830         


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr 
        835                 840                 845             


Tyr Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala 
    850                 855                 860                 


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
865                 870                 875                 880 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                885                 890                 895     


Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
            900                 905                 910         


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Thr Val 
        915                 920                 925             


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
    930                 935                 940                 


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
945                 950                 955                 960 


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
                965                 970                 975     


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Gly Thr Asp Trp Ser Asp His 
            980                 985                 990         


Leu Gln Val Phe Gly Gly Gly Thr  Lys Leu Thr Val Leu  Ala Ala Ala 
        995                 1000                 1005             


Gly Ser  His His His His His  His 
    1010                 1015     


<210>  29
<211>  1521
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser 
    130                 135                 140                 


Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln Asn 
145                 150                 155                 160 


Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
                165                 170                 175     


Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp 
            180                 185                 190         


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His 
    210                 215                 220                 


Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala 
            260                 265                 270         


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        275                 280                 285             


Phe Thr Thr Tyr Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp 
    290                 295                 300                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr 
305                 310                 315                 320 


Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser 
                325                 330                 335     


Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr 
        355                 360                 365             


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
385                 390                 395                 400 


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys Lys 
                405                 410                 415     


Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
        435                 440                 445             


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys 
465                 470                 475                 480 


Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu 
                485                 490                 495     


Glu Ile Asn Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu 
            500                 505                 510         


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Val 
        515                 520                 525             


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp 
    530                 535                 540                 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn 
545                 550                 555                 560 


Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val 
                565                 570                 575     


Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
            580                 585                 590         


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser 
        595                 600                 605             


Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    610                 615                 620                 


Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln 
625                 630                 635                 640 


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys 
                645                 650                 655     


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 
            660                 665                 670         


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile 
        675                 680                 685             


Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg 
    690                 695                 700                 


Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu 
705                 710                 715                 720 


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
                725                 730                 735     


Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln Gly Thr Leu 
            740                 745                 750         


Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        755                 760                 765             


Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser 
    770                 775                 780                 


Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His 
785                 790                 795                 800 


Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln 
                805                 810                 815     


Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile 
            820                 825                 830         


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
        835                 840                 845             


Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val 
    850                 855                 860                 


Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val 
865                 870                 875                 880 


Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln 
                885                 890                 895     


Pro Ser Ser Val Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys 
            900                 905                 910         


Gly Gly His Asn Ile Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg 
        915                 920                 925             


Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro 
    930                 935                 940                 


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 
945                 950                 955                 960 


Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr 
                965                 970                 975     


Cys Gln Val Trp Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys 
            980                 985                 990         


Leu Thr Val Leu Gly Gly Ser Gly  Gly Ser Gly Gly Ser  Glu Val Gln 
        995                 1000                 1005             


Leu Val  Gln Ser Gly Ala Glu  Val Lys Lys Pro Gly  Glu Ser Leu 
    1010                 1015                 1020             


Lys Ile  Ser Cys Lys Gly Ser  Gly Tyr Ser Phe Thr  Ser Asn Trp 
    1025                 1030                 1035             


Ile Gly  Trp Val Arg Gln Met  Pro Gly Lys Gly Leu  Glu Trp Met 
    1040                 1045                 1050             


Gly Met  Ile Trp Pro Gly Asp  Ser Asp Thr Met Tyr  Ser Pro Ser 
    1055                 1060                 1065             


Phe Gln  Gly Gln Val Thr Ile  Ser Ala Asp Glu Ser  Ile Asn Thr 
    1070                 1075                 1080             


Ala Tyr  Leu Gln Trp Ser Ser  Leu Lys Ala Ser Asp  Thr Ala Met 
    1085                 1090                 1095             


Tyr Tyr  Cys Ala Arg Arg Glu  Thr Thr Thr Val Gly  Arg Tyr Tyr 
    1100                 1105                 1110             


Tyr Ala  Met Asp Tyr Trp Gly  Gln Gly Thr Leu Val  Thr Val Ser 
    1115                 1120                 1125             


Ser Gly  Gly Ser Gly Gly Ser  Gly Gly Ser Ser Tyr  Val Leu Thr 
    1130                 1135                 1140             


Gln Pro  Pro Ser Val Ser Val  Ala Pro Gly Gln Thr  Ala Arg Ile 
    1145                 1150                 1155             


Thr Cys  Gly Gly Asn Asn Ile  Gly Ser Lys Thr Val  His Trp Tyr 
    1160                 1165                 1170             


Gln Gln  Lys Pro Gly Gln Ala  Pro Val Leu Val Val  Tyr Asp Asp 
    1175                 1180                 1185             


Ser Asp  Arg Pro Ser Gly Ile  Pro Glu Arg Phe Ser  Gly Ser Asn 
    1190                 1195                 1200             


Ser Gly  Asn Thr Ala Thr Leu  Thr Ile Ser Arg Val  Glu Ala Gly 
    1205                 1210                 1215             


Asp Glu  Ala Asp Tyr Tyr Cys  Gln Val Gly Thr Asp  Trp Ser Asp 
    1220                 1225                 1230             


His Leu  Gln Val Phe Gly Gly  Gly Thr Lys Leu Thr  Val Leu Gly 
    1235                 1240                 1245             


Gly Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1250                 1255                 1260             


Gly Ser  Gly Gly Ser Glu Val  Gln Leu Val Gln Ser  Gly Ala Glu 
    1265                 1270                 1275             


Val Lys  Lys Pro Gly Glu Ser  Leu Lys Ile Ser Cys  Lys Gly Ser 
    1280                 1285                 1290             


Gly Tyr  Ser Phe Thr Ser Asn  Trp Ile Gly Trp Val  Arg Gln Met 
    1295                 1300                 1305             


Pro Gly  Lys Gly Leu Glu Trp  Met Gly Met Ile Trp  Pro Gly Asp 
    1310                 1315                 1320             


Ser Asp  Thr Met Tyr Ser Pro  Ser Phe Gln Gly Gln  Val Thr Ile 
    1325                 1330                 1335             


Ser Ala  Asp Glu Ser Ile Asn  Thr Ala Tyr Leu Gln  Trp Ser Ser 
    1340                 1345                 1350             


Leu Lys  Ala Ser Asp Thr Ala  Met Tyr Tyr Cys Ala  Arg Arg Glu 
    1355                 1360                 1365             


Thr Thr  Thr Val Gly Arg Tyr  Tyr Tyr Ala Met Asp  Tyr Trp Gly 
    1370                 1375                 1380             


Gln Gly  Thr Leu Val Thr Val  Ser Ser Gly Gly Ser  Gly Gly Ser 
    1385                 1390                 1395             


Gly Gly  Ser Ser Tyr Val Leu  Thr Gln Pro Pro Ser  Val Ser Val 
    1400                 1405                 1410             


Ala Pro  Gly Gln Thr Ala Arg  Ile Thr Cys Gly Gly  Asn Asn Ile 
    1415                 1420                 1425             


Gly Ser  Lys Thr Val His Trp  Tyr Gln Gln Lys Pro  Gly Gln Ala 
    1430                 1435                 1440             


Pro Val  Leu Val Val Tyr Asp  Asp Ser Asp Arg Pro  Ser Gly Ile 
    1445                 1450                 1455             


Pro Glu  Arg Phe Ser Gly Ser  Asn Ser Gly Asn Thr  Ala Thr Leu 
    1460                 1465                 1470             


Thr Ile  Ser Arg Val Glu Ala  Gly Asp Glu Ala Asp  Tyr Tyr Cys 
    1475                 1480                 1485             


Gln Val  Gly Thr Asp Trp Ser  Asp His Leu Gln Val  Phe Gly Gly 
    1490                 1495                 1500             


Gly Thr  Lys Leu Thr Val Leu  Ala Ala Ala Gly Ser  His His His 
    1505                 1510                 1515             


His His  His 
    1520     


<210>  30
<211>  767
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  30

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
                165                 170                 175     


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
            180                 185                 190         


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
    210                 215                 220                 


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
            260                 265                 270         


Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly 
        275                 280                 285             


Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val 
    290                 295                 300                 


Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
                325                 330                 335     


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn 
            340                 345                 350         


Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala 
    370                 375                 380                 


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
385                 390                 395                 400 


Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro 
                405                 410                 415     


Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp 
            420                 425                 430         


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
        435                 440                 445             


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
    450                 455                 460                 


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Leu Gly Ser Ser Trp Thr Asn 
465                 470                 475                 480 


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                485                 490                 495     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
            500                 505                 510         


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        515                 520                 525             


Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val Arg Gln 
    530                 535                 540                 


Arg Pro Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser 
545                 550                 555                 560 


Gly Tyr Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr 
                565                 570                 575     


Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr 
            580                 585                 590         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly 
        595                 600                 605             


Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val 
    610                 615                 620                 


Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
                645                 650                 655     


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys 
            660                 665                 670         


Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys 
        675                 680                 685             


Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 
    690                 695                 700                 


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
705                 710                 715                 720 


Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe 
                725                 730                 735     


Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
            740                 745                 750         


Leu Glu Ile Asn Ala Ala Ala Gly Ser His His His His His His 
        755                 760                 765         


<210>  31
<211>  251
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  31

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Pro 
                85                  90                  95      


Leu Ile Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr 
                165                 170                 175     


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe 
    210                 215                 220                 


Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala 
225                 230                 235                 240 


Ala Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
                245                 250     


<210>  32
<211>  769
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  32

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
                165                 170                 175     


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
            180                 185                 190         


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
    210                 215                 220                 


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            260                 265                 270         


Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        275                 280                 285             


Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    290                 295                 300                 


Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr 
305                 310                 315                 320 


Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr 
                325                 330                 335     


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser 
385                 390                 395                 400 


Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu 
                405                 410                 415     


Pro Lys Gln Tyr Ala Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            420                 425                 430         


Val Leu Val Ile Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu 
        435                 440                 445             


Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser 
    450                 455                 460                 


Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp 
465                 470                 475                 480 


Ser Ser Gly Thr Pro Leu Ile Val Phe Gly Thr Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln 
            500                 505                 510         


Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser 
        515                 520                 525             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val 
    530                 535                 540                 


Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro 
545                 550                 555                 560 


Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr 
                565                 570                 575     


Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser 
            580                 585                 590         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp 
        595                 600                 605             


Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
    610                 615                 620                 


Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val Met Thr 
                645                 650                 655     


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Thr Val 
            660                 665                 670         


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Phe Gln 
        675                 680                 685             


Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr 
    690                 695                 700                 


Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
705                 710                 715                 720 


Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu 
                725                 730                 735     


Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly 
            740                 745                 750         


Thr Lys Leu Glu Ile Asn Ala Ala Ala Gly Ser His His His His His 
        755                 760                 765             


His 
    


<210>  33
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  33

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ser Ser Trp Thr Asn Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro 
    130                 135                 140                 


Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys 
145                 150                 155                 160 


Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val 
                165                 170                 175     


Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
            180                 185                 190         


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln 
        195                 200                 205             


Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser 
    210                 215                 220                 


Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly 
225                 230                 235                 240 


Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
                245                 


<210>  34
<211>  781
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  34

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
                165                 170                 175     


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
            180                 185                 190         


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
    210                 215                 220                 


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            260                 265                 270         


Lys Pro Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        275                 280                 285             


Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    290                 295                 300                 


Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr 
305                 310                 315                 320 


Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr 
                325                 330                 335     


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
385                 390                 395                 400 


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
                405                 410                 415     


Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
            420                 425                 430         


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
        435                 440                 445             


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
    450                 455                 460                 


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
465                 470                 475                 480 


Ala Met Tyr Tyr Cys Ala Arg Leu Gly Ser Ser Trp Thr Asn Asp Ala 
                485                 490                 495     


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly 
            500                 505                 510         


Ser Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala 
        515                 520                 525             


Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
    530                 535                 540                 


Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val Arg Gln Arg Pro 
545                 550                 555                 560 


Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Tyr 
                565                 570                 575     


Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp 
            580                 585                 590         


Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
        595                 600                 605             


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr 
    610                 615                 620                 


Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
625                 630                 635                 640 


Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                645                 650                 655     


Ser Gly Gly Ser Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Lys 
            660                 665                 670         


Phe Met Ser Thr Ser Val Gly Asp Arg Val Thr Val Thr Cys Lys Ala 
        675                 680                 685             


Ser Gln Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly 
    690                 695                 700                 


Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly 
705                 710                 715                 720 


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                725                 730                 735     


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
            740                 745                 750         


Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        755                 760                 765             


Ile Asn Ala Ala Ala Gly Ser His His His His His His 
    770                 775                 780     


<210>  35
<211>  237
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  35

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Pro 
                85                  90                  95      


Leu Ile Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Ser 
            100                 105                 110         


Gly Gly Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val 
        115                 120                 125             


Ser Val Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn 
    130                 135                 140                 


Ile Gly Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
145                 150                 155                 160 


Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro 
                165                 170                 175     


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
            180                 185                 190         


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp 
        195                 200                 205             


Asp Asn Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
    210                 215                 220                 


Ala Ala Ala Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
225                 230                 235         


<210>  36
<211>  755
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  36

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
                165                 170                 175     


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
            180                 185                 190         


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
    210                 215                 220                 


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
            260                 265                 270         


Ala Pro Gly Gln Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly 
        275                 280                 285             


Ser Lys Asn Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val 
    290                 295                 300                 


Leu Val Ile Tyr Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
                325                 330                 335     


Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn 
            340                 345                 350         


Tyr Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
        355                 360                 365             


Ser Gly Gly Ser Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser 
    370                 375                 380                 


Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp 
385                 390                 395                 400 


Ala Leu Pro Lys Gln Tyr Ala Tyr Trp Tyr Gln Gln Lys Pro Gly Gln 
                405                 410                 415     


Ala Pro Val Leu Val Ile Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile 
            420                 425                 430         


Pro Glu Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr Val Thr Leu Thr 
        435                 440                 445             


Ile Ser Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser 
    450                 455                 460                 


Ala Asp Ser Ser Gly Thr Pro Leu Ile Val Phe Gly Thr Gly Thr Lys 
465                 470                 475                 480 


Leu Thr Val Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gln Val Gln 
                485                 490                 495     


Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys 
            500                 505                 510         


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His 
        515                 520                 525             


Trp Val Arg Gln Arg Pro Gly His Asp Leu Glu Trp Ile Gly Tyr Ile 
    530                 535                 540                 


Asn Pro Ser Ser Gly Tyr Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys 
545                 550                 555                 560 


Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu 
                565                 570                 575     


Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg 
            580                 585                 590         


Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ile Val 
625                 630                 635                 640 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
                645                 650                 655     


Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
            660                 665                 670         


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
        675                 680                 685             


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
    690                 695                 700                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
705                 710                 715                 720 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
                725                 730                 735     


Gly Gly Thr Lys Leu Glu Ile Asn Ala Ala Ala Gly Ser His His His 
            740                 745                 750         


His His His 
        755 


<210>  37
<211>  263
<212>  PRT
<213>  artificial

<220>
<223>  Fv polypeptide

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ser Ser Trp Thr Asn Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
    130                 135                 140                 


Gly Glu Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
145                 150                 155                 160 


Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
                165                 170                 175     


Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln 
            180                 185                 190         


Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr 
        195                 200                 205             


Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gly Ser Asp 
                245                 250                 255     


Tyr Lys Asp Asp Asp Asp Lys 
            260             


<210>  38
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  FLAG tag

<400>  38

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  STREP II Tag

<400>  39

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  40
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  C Tag

<400>  40

Glu Pro Glu Ala 
1               


