                         SEQUENCE LISTING

<110>  Max-Delbrck Center Berlin
 
<120>  High Avidity HPV T-Cell Receptors

<130>  M33020WO

<150>  EP15190230.1
<151>  2015 10 16


<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Human papillomavirus

<400>  1

Tyr Ile Ile Phe Val Tyr Ile Pro Leu 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Human papillomavirus

<400>  2

Lys Leu Pro Gln Leu Cys Thr Glu Leu 
1               5                   


<210>  3
<211>  10
<212>  PRT
<213>  Human papillomavirus

<400>  3

Thr Ile His Asp Ile Ile Leu Glu Cys Val 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  Human papillomavirus

<400>  4

Tyr Met Leu Asp Leu Gln Pro Glu Thr 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Human papillomavirus

<400>  5

Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Human papillomavirus

<400>  6

Thr Leu Gly Ile Val Cys Pro Ile 
1               5               


<210>  7
<211>  9
<212>  PRT
<213>  Human papillomavirus

<400>  7

Lys Cys Ile Asp Phe Tyr Ser Arg Ile 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Human papillomavirus

<400>  8

Phe Gln Gln Leu Phe Leu Asn Thr Leu 
1               5                   


<210>  9
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  9

Cys Ala Ala Ser Ser Tyr Asn Gln Gly Gly Lys Leu Ile Phe 
1               5                   10                  


<210>  10
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Ile Leu Arg Asp Val Asn Ala Gly Gly Thr Ser Tyr Gly Lys Leu 
1               5                   10                  15      


Thr Phe 
        


<210>  11
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Ala Ser Ser Leu Leu Ser Ser Tyr Asn Glu Gln Phe Phe 
1               5                   10                  


<210>  12
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Ala Val Asn Val Asp Phe Asn Lys Phe Tyr Phe 
1               5                   10          


<210>  13
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  13

Cys Ala Ser Ser Gln Asp Trp Asn Asn Glu Gln Phe Phe 
1               5                   10              


<210>  14
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Ala Val Gln Ala Asn Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Ala Ser Ser Leu Trp Gly Arg Leu Ala Lys Asn Ile Gln Tyr Phe 
1               5                   10                  15      


<210>  16
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Ala Val Arg Glu Thr Ser Gly Ser Arg Leu Thr Phe 
1               5                   10              


<210>  17
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Ala Ser Ser Phe Trp Gly Arg Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Ala Thr Val Ser Thr Asp Ser Trp Gly Lys Lys Leu Gln Phe 
1               5                   10                  15  


<210>  19
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Ala Ile Ser Asp Ser Asn Gly Ile Asn Ile Gln Tyr Phe 
1               5                   10                  


<210>  20
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Ala Ser Ser Leu Trp Gly Arg Ala Gly Lys Asp Thr Gln Tyr Phe 
1               5                   10                  15      


<210>  21
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  21

Cys Ala Val Ser Leu Asn Ser Gly Asn Thr Pro Leu Val Phe 
1               5                   10                  


<210>  22
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  22

Cys Ser Ala Arg Asp Leu Ala Gly Asn Thr Gly Glu Leu Phe Phe 
1               5                   10                  15  


<210>  23
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  23

Cys Gly Thr Gly Thr Asp Ser Trp Gly Lys Leu Gln Phe 
1               5                   10              


<210>  24
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  24

Cys Ala Ser Ser Pro Gly Leu Ala Gly Gly Glu Gln Phe Phe 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Ala Val Glu Pro Asn Ser Gly Asn Thr Pro Leu Val Phe 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  26

Cys Ala Ser Ser Leu Ile Ile Ser Tyr Asn Glu Gln Phe Phe 
1               5                   10                  


<210>  27
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  27

Cys Ala Tyr Arg Ser Ala Pro Tyr Ser Gly Ala Gly Ser Tyr Gln Leu 
1               5                   10                  15      


Thr Phe 
        


<210>  28
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  28

Cys Ala Ser Ser Gln Ala Pro Gly Leu Ala Gly Ala Glu Gln Tyr Phe 
1               5                   10                  15      


<210>  29
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Ser Tyr Asn Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu 
        115                 120                 125             


Ser Val Lys Pro Asn 
    130             


<210>  30
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Lys Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Arg Asp Val Asn Ala 
            100                 105                 110         


Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu 
        115                 120                 125             


Thr Val His Pro Asn 
    130             


<210>  31
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Leu Leu Ser Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu 
    130             


<210>  32
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys 
    50                  55                  60                  


Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu 
                85                  90                  95      


Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Val Asn Val Asp Phe Asn Lys Phe Tyr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Asn Val Lys Pro Asn 
    130             


<210>  33
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Ile Asp Thr Glu Val Thr Gln Thr Pro Lys His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Met Gly His 
        35                  40                  45              


Arg Ala Met Tyr Trp Tyr Lys Gln Lys Ala Lys Lys Pro Pro Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Tyr Glu Lys Leu Ser Ile Asn Glu Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser Leu Leu Asn Leu His 
                85                  90                  95      


Leu His Ala Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Asp Trp Asn Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu 
    130     


<210>  34
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu 
            20                  25                  30          


Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val 
        35                  40                  45              


Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly 
    50                  55                  60                  


Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys 
65                  70                  75                  80  


Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile 
                85                  90                  95      


Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Gln 
            100                 105                 110         


Ala Asn Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr 
        115                 120                 125             


Gln Leu Thr Val Trp Pro Asp 
    130                 135 


<210>  35
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Trp Gly Arg Leu Ala Lys Asn Ile Gln Tyr Phe Gly Ala Gly 
        115                 120                 125             


Thr Arg Leu Ser Val Leu 
    130                 


<210>  36
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro Asp 
    130         


<210>  37
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Phe Trp Gly Arg Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu 
    130             


<210>  38
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Val 
            100                 105                 110         


Ser Thr Asp Ser Trp Gly Lys Leu Gln Phe Gly Ala Gly Thr Gln Val 
        115                 120                 125             


Val Val Thr Pro Asp 
    130             


<210>  39
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Arg Ser Trp Pro Gly Pro Glu Met Gly Thr Arg Leu Phe Phe Tyr 
1               5                   10                  15      


Val Ala Leu Cys Leu Leu Trp Thr Gly His Met Asp Ala Gly Ile Thr 
            20                  25                  30          


Gln Ser Pro Arg His Lys Val Thr Glu Thr Gly Thr Pro Val Thr Leu 
        35                  40                  45              


Arg Cys His Gln Thr Glu Asn His Arg Tyr Met Tyr Trp Tyr Arg Gln 
    50                  55                  60                  


Asp Pro Gly His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly Val Lys 
65                  70                  75                  80  


Asp Thr Asp Lys Gly Glu Val Ser Asp Gly Tyr Ser Val Ser Arg Ser 
                85                  90                  95      


Lys Thr Glu Asp Phe Leu Leu Thr Leu Glu Ser Ala Thr Ser Ser Gln 
            100                 105                 110         


Thr Ser Val Tyr Phe Cys Ala Ile Ser Asp Ser Asn Gly Ile Asn Ile 
        115                 120                 125             


Gln Tyr Phe Gly Ala Gly Thr Arg Leu Ser Val Leu 
    130                 135                 140 


<210>  40
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Trp Gly Arg Ala Gly Lys Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  41
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Leu Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Leu Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg 
        115                 120                 125             


Leu Ser Val Ile Ala Asn 
    130                 


<210>  42
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Asp 
            100                 105                 110         


Leu Ala Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu 
        115                 120                 125             


Thr Val Leu 
    130     


<210>  43
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Glu Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu 
1               5                   10                  15      


Thr Trp Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile 
            20                  25                  30          


Leu Arg Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala 
        35                  40                  45              


Leu Tyr Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val 
    50                  55                  60                  


Phe Leu Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys 
65                  70                  75                  80  


Ile Ser Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu 
                85                  90                  95      


Thr Ala Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Gly 
            100                 105                 110         


Thr Asp Ser Trp Gly Lys Leu Gln Phe Gly Ala Gly Thr Gln Val Val 
        115                 120                 125             


Val Thr Pro Asp 
    130         


<210>  44
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Leu Ala Gly Gly Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu 
    130             


<210>  45
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Lys Arg Ile Leu Gly Ala Leu Leu Gly Leu Leu Ser Ala Gln Val 
1               5                   10                  15      


Cys Cys Val Arg Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile 
            20                  25                  30          


Leu Gln Glu Gly Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser 
        35                  40                  45              


Val Asn Asn Leu Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile 
    50                  55                  60                  


Asn Leu Phe Tyr Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser 
65                  70                  75                  80  


Ala Thr Thr Val Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser 
                85                  90                  95      


Ser Gln Thr Thr Asp Ser Gly Val Tyr Phe Cys Ala Val Glu Pro Asn 
            100                 105                 110         


Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser Val 
        115                 120                 125             


Ile Ala Asn 
    130     


<210>  46
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Tyr His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Arg Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Glu Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Ile Ile Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu 
    130             


<210>  47
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Arg Ser Ala Pro Tyr Ser Gly Ala Gly Ser Tyr Gln Leu Thr 
        115                 120                 125             


Phe Gly Lys Gly Thr Lys Leu Ser Val Ile Pro Asn 
    130                 135                 140 


<210>  48
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Met Glu Thr Gly Val Thr Gln Thr Pro Arg His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Leu Gly His 
        35                  40                  45              


Asn Ala Met Tyr Trp Tyr Lys Gln Ser Ala Lys Lys Pro Leu Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Asn Phe Lys Glu Gln Thr Glu Asn Asn Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser His Leu Phe Leu His 
                85                  90                  95      


Leu His Thr Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Ala Pro Gly Leu Ala Gly Ala Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr 
    130                 


