                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  COMPOSITIONS AND METHODS USEFUL IN TREATING STARGARDT'S DISEASE 
       AND OTHER OCULAR DISORDERS

<130>  15-7361PCT

<150>  62/239,480
<151>  2015-10-09

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 77-100 with LIR motif (87-90)

<400>  1

Arg Asn Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr 
1               5                   10                  15      


Asp Ile His Thr Leu Arg Gln Val 
            20                  


<210>  2
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bovine mutant MREG-W87A and MREGL90A

<400>  2

Arg Asn Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr 
1               5                   10                  15      


Asp Ile Tyr Thr Leu Arg Gln Ile 
            20                  


<210>  3
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutant MREG-W87A and MREG L90A

<400>  3

Arg Asn Gln Gln Thr Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr 
1               5                   10                  15      


Asp Ile Tyr Thr Leu Arg Gln Ile 
            20                  


<210>  4
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  rat mutant MREG-W87A and MREG L90A

<400>  4

Arg Asn Gln Gln Thr Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr 
1               5                   10                  15      


Asp Ile Tyr Thr Leu Arg Gln Ile 
            20                  


<210>  5
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  xenopus mutant-MREG-W87A and MREG L90A

<400>  5

Arg Asn Gln Leu Glu Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr 
1               5                   10                  15      


Glu Ile Tyr Thr Leu Arg Gln Ala 
            20                  


<210>  6
<211>  911
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DS MREG delta 10


<220>
<221>  CDS
<222>  (62)..(703)

<400>  6
tcatctcaat cggatctggt tcgcgtggat ccccggggct gagggactgg aaacagtatt       60

c atg ggg ctg agg gac tgg ctg aga acc gtg tgc tgc tgc tgc ggg tgc      109
  Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys         
  1               5                   10                  15              

gag tgc ttg gag gag cgc gcc ctg cct gag aag gag ccc ctc gtc agt        157
Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser           
            20                  25                  30                    

gat aac aat cca tat tcc tca ttt gga gca act ctg gtg agg gat gat        205
Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp           
        35                  40                  45                        

gag aag aat tta tgg agt atg ccc cat gat gtg tcc cac aca gag gca        253
Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala           
    50                  55                  60                            

gac gac gac aga acc ctg tac aat ttg ata gtc att cgt aat cag cag        301
Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln           
65                  70                  75                  80            

gcc aaa gac tca gag gag tgg cag aag ctc aac cat gat atc cat acc        349
Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn His Asp Ile His Thr           
                85                  90                  95                

ctg cgg cag gtt cga agg gaa gta aga aac aga tgg aag tgc atc tta        397
Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu           
            100                 105                 110                   

gaa gat tta ggt ttt caa aag gaa gct gac tct ttg ttg tca gtg act        445
Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr           
        115                 120                 125                       

aaa ctc agc acc atc agt gat tct aaa aac aca agg aaa gct cga gag        493
Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu           
    130                 135                 140                           

atg ttg tta aaa ctg gct gaa gaa acc aat att ttc cca aca agt tgg        541
Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp           
145                 150                 155                 160           

gag ctc tca gag aga tat ctc ttt gtt gtg gac cgt ctc att gca ctt        589
Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu           
                165                 170                 175               

gat gct gca gag gag ttc ttt aag ctt gct cgt cga act tac ccc aag        637
Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys           
            180                 185                 190                   

aag cct ggg gtt cca tgc ctg gca gat ggc cag aaa taa ctg cac tac        685
Lys Pro Gly Val Pro Cys Leu Ala Asp Gly Gln Lys     Leu His Tyr           
        195                 200                     205                   

ctt ccg ttt cca agt ccc gggaattcat cgtgactgac tgacgatctg               733
Leu Pro Phe Pro Ser Pro                                                   
        210                                                               

cctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt      793

cacagcttgt ctgtaagcgg atgccgggag cagacagccc gtcaggcgcg tcagcggtgt      853

tggcggtgtc ggggcgcagc catgacccag tcacgtagcg awtagcggag tgtataaa        911


<210>  7
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn His Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys 
            180                 185                 190         


Lys Pro Gly Val Pro Cys Leu Ala Asp Gly Gln Lys 
        195                 200                 


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Leu His Tyr Leu Pro Phe Pro Ser Pro 
1               5                   


<210>  9
<211>  931
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DS MREG Delta 30


<220>
<221>  CDS
<222>  (67)..(708)

<400>  9
gyccaatctc aaatcggatc tggttccgcg tggatccccg gggctgaggg actggaaaca       60

gtattc atg ggg ctg agg gac tgg ctg aga acc gtg tgc tgc tgc tgc         108
       Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys            
       1               5                   10                             

ggg tgc gag tgc ttg gag gag cgc gcc ctg cct gag aag gag ccc ctc        156
Gly Cys Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu           
15                  20                  25                  30            

gtc agt gat aac aat cca tat tcc tca ttt gga gca act ctg gtg agg        204
Val Ser Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg           
                35                  40                  45                

gat gat gag aag aat tta tgg agt atg ccc cat gat gtg tcc cac aca        252
Asp Asp Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr           
            50                  55                  60                    

gag gca gac gac gac aga acc ctg tac aat ttg ata gtc att cgt aat        300
Glu Ala Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn           
        65                  70                  75                        

cag cag gcc aaa gac tca gag gag tgg cag aag ctc aac cat gat atc        348
Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn His Asp Ile           
    80                  85                  90                            

cat acc ctg cgg cag gtt cga agg gaa gta aga aac aga tgg aag tgc        396
His Thr Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys           
95                  100                 105                 110           

atc tta gaa gat tta ggt ttt caa aag gaa gct gac tct ttg ttg tca        444
Ile Leu Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser           
                115                 120                 125               

gtg act aaa ctc agc acc atc agt gat tct aaa aac aca agg aaa gct        492
Val Thr Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala           
            130                 135                 140                   

cga gag atg ttg tta aaa ctg gct gaa gaa acc aat att ttc cca aca        540
Arg Glu Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr           
        145                 150                 155                       

agt tgg gag ctc tca gag aga tat ctc ttt gtt gtg gac cgt ctc att        588
Ser Trp Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile           
    160                 165                 170                           

gca ctt gat gct gca gaa gag ttc ttt aag taa gct cgt cga act tac        636
Ala Leu Asp Ala Ala Glu Glu Phe Phe Lys     Ala Arg Arg Thr Tyr           
175                 180                     185                           

ccc aag aag cct ggg gtt cca tgc ctg gca gat ggc cag aaa taa ctg        684
Pro Lys Lys Pro Gly Val Pro Cys Leu Ala Asp Gly Gln Lys     Leu           
190                 195                 200                               

cac tac ctt ccg ttt cca agt ccc gggaattcat cgtgactgac tgacgatctg       738
His Tyr Leu Pro Phe Pro Ser Pro                                           
205                 210                                                   

cctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt      798

cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcaggcgc gtcagcgggt      858

gttggcgggt gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtataaa      918

ttcttgaagr acg                                                         931


<210>  10
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn His Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Lys 
            180                 


<210>  11
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  11

Ala Arg Arg Thr Tyr Pro Lys Lys Pro Gly Val Pro Cys Leu Ala Asp 
1               5                   10                  15      


Gly Gln Lys 
            


<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  12

Leu His Tyr Leu Pro Phe Pro Ser Pro 
1               5                   


<210>  13
<211>  940
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  USMREGDelta10


<220>
<221>  CDS
<222>  (275)..(940)

<400>  13
actgcacggt gcaccaatgc ttctggcgtc aggcagccat cgaagctgtg gtatgctgtg       60

caggtcgtaa atcactgcat aattcgtgtc gctcaaggcg cactcccgtt ctggataatg      120

ttttttgcgc cgacatcata acggttctgg caaatattct gaaatgagct gttgacaatt      180

aatcatcggc tcgtataatg tgtggaattg tgagcggata acaatttcac acaggaaaca      240

gtattcatgg ggctgaggga ctggaaacag tatt cat ggg gct gag gga ctg gct      295
                                      His Gly Ala Glu Gly Leu Ala         
                                      1               5                   

gag aac cgt gtg ctg ctg ctg cgg gtg cga gtg ctt gga gga gcg cgc        343
Glu Asn Arg Val Leu Leu Leu Arg Val Arg Val Leu Gly Gly Ala Arg           
        10                  15                  20                        

cct gcc tga gaa gga gcc cct cgt cag tga taa caa tcc ata ttc ctc        391
Pro Ala     Glu Gly Ala Pro Arg Gln         Gln Ser Ile Phe Leu           
    25                      30                          35                

att tgg agc aac tct ggt gag gga tga tga gaa gaa ttt atg gag tat        439
Ile Trp Ser Asn Ser Gly Glu Gly         Glu Glu Phe Met Glu Tyr           
            40                          45                  50            

gcc cca tga tgt gtc cca cac aga ggc aga cga cga cag aac cct gta        487
Ala Pro     Cys Val Pro His Arg Gly Arg Arg Arg Gln Asn Pro Val           
                    55                  60                  65            

caa ttt gat agt cat tcg taa tca gca ggc caa aga ctc aga gga gtg        535
Gln Phe Asp Ser His Ser     Ser Ala Gly Gln Arg Leu Arg Gly Val           
                70                      75                  80            

gca gaa gct caa cta tga tat cca tac cct gcg gca ggt tcg aag gga        583
Ala Glu Ala Gln Leu     Tyr Pro Tyr Pro Ala Ala Gly Ser Lys Gly           
                85                      90                  95            

agt aag aaa cag atg gaa gtg cat ctt aga aga ttt agg ttt tca aaa        631
Ser Lys Lys Gln Met Glu Val His Leu Arg Arg Phe Arg Phe Ser Lys           
                100                 105                 110               

gga agc tga ctc ttt gtt gtc agt gac taa act cag cac cat cag tga        679
Gly Ser     Leu Phe Val Val Ser Asp     Thr Gln His His Gln               
                115                     120                               

ttc taa aaa cac aag gaa agc tcg aga gat gtt gtt aaa act ggc tga        727
Phe     Lys His Lys Glu Ser Ser Arg Asp Val Val Lys Thr Gly               
125                     130                 135                           

aga aac caa tat ttt ccc aac aag ttg gga gct ctc aga gag ata tct        775
Arg Asn Gln Tyr Phe Pro Asn Lys Leu Gly Ala Leu Arg Glu Ile Ser           
    140                 145                 150                           

ctt tgt tgt gga ccg tct cat tgc act tga tgc tgc aga gga gtt ctt        823
Leu Cys Cys Gly Pro Ser His Cys Thr     Cys Cys Arg Gly Val Leu           
155                 160                     165                           

taa gct tgc tcg tcg aac tta ccc caa gaa gcc tgg ggt tcc atg cct        871
    Ala Cys Ser Ser Asn Leu Pro Gln Glu Ala Trp Gly Ser Met Pro           
    170                 175                 180                           

ggc aga tgg cca gac cat ggc ccc tat act agg tta ttg gaa aat aag        919
Gly Arg Trp Pro Asp His Gly Pro Tyr Thr Arg Leu Leu Glu Asn Lys           
185                 190                 195                 200           

ggc ctg tgc aac cca ctc gat                                            940
Gly Leu Cys Asn Pro Leu Asp                                               
                205                                                       


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

His Gly Ala Glu Gly Leu Ala Glu Asn Arg Val Leu Leu Leu Arg Val 
1               5                   10                  15      


Arg Val Leu Gly Gly Ala Arg Pro Ala 
            20                  25  


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Glu Gly Ala Pro Arg Gln 
1               5       


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Gln Ser Ile Phe Leu Ile Trp Ser Asn Ser Gly Glu Gly 
1               5                   10              


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Glu Glu Phe Met Glu Tyr Ala Pro 
1               5               


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Cys Val Pro His Arg Gly Arg Arg Arg Gln Asn Pro Val Gln Phe Asp 
1               5                   10                  15      


Ser His Ser 
            


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Ser Ala Gly Gln Arg Leu Arg Gly Val Ala Glu Ala Gln Leu 
1               5                   10                  


<210>  20
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Tyr Pro Tyr Pro Ala Ala Gly Ser Lys Gly Ser Lys Lys Gln Met Glu 
1               5                   10                  15      


Val His Leu Arg Arg Phe Arg Phe Ser Lys Gly Ser 
            20                  25              


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Leu Phe Val Val Ser Asp 
1               5       


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Thr Gln His His Gln 
1               5   


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Lys His Lys Glu Ser Ser Arg Asp Val Val Lys Thr Gly 
1               5                   10              


<210>  24
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Arg Asn Gln Tyr Phe Pro Asn Lys Leu Gly Ala Leu Arg Glu Ile Ser 
1               5                   10                  15      


Leu Cys Cys Gly Pro Ser His Cys Thr 
            20                  25  


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Cys Cys Arg Gly Val Leu 
1               5       


<210>  26
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Ala Cys Ser Ser Asn Leu Pro Gln Glu Ala Trp Gly Ser Met Pro Gly 
1               5                   10                  15      


Arg Trp Pro Asp His Gly Pro Tyr Thr Arg Leu Leu Glu Asn Lys Gly 
            20                  25                  30          


Leu Cys Asn Pro Leu Asp 
        35              


<210>  27
<211>  931
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DS MREGDeleta30, Clone #1


<220>
<221>  CDS
<222>  (67)..(708)

<400>  27
gyccaatctc aaatcggatc tggttccgcg tggatccccg gggctgaggg actggaaaca       60

gtattc atg ggg ctg agg gac tgg ctg aga acc gtg tgc tgc tgc tgc         108
       Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys            
       1               5                   10                             

ggg tgc gag tgc ttg gag gag cgc gcc ctg cct gag aag gag ccc ctc        156
Gly Cys Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu           
15                  20                  25                  30            

gtc agt gat aac aat cca tat tcc tca ttt gga gca act ctg gtg agg        204
Val Ser Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg           
                35                  40                  45                

gat gat gag aag aat tta tgg agt atg ccc cat gat gtg tcc cac aca        252
Asp Asp Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr           
            50                  55                  60                    

gag gca gac gac gac aga acc ctg tac aat ttg ata gtc att cgt aat        300
Glu Ala Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn           
        65                  70                  75                        

cag cag gcc aaa gac tca gag gag tgg cag aag ctc aac cat gat atc        348
Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn His Asp Ile           
    80                  85                  90                            

cat acc ctg cgg cag gtt cga agg gaa gta aga aac aga tgg aag tgc        396
His Thr Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys           
95                  100                 105                 110           

atc tta gaa gat tta ggt ttt caa aag gaa gct gac tct ttg ttg tca        444
Ile Leu Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser           
                115                 120                 125               

gtg act aaa ctc agc acc atc agt gat tct aaa aac aca agg aaa gct        492
Val Thr Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala           
            130                 135                 140                   

cga gag atg ttg tta aaa ctg gct gaa gaa acc aat att ttc cca aca        540
Arg Glu Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr           
        145                 150                 155                       

agt tgg gag ctc tca gag aga tat ctc ttt gtt gtg gac cgt ctc att        588
Ser Trp Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile           
    160                 165                 170                           

gca ctt gat gct gca gaa gag ttc ttt aag taa gct cgt cga act tac        636
Ala Leu Asp Ala Ala Glu Glu Phe Phe Lys     Ala Arg Arg Thr Tyr           
175                 180                     185                           

ccc aag aag cct ggg gtt cca tgc ctg gca gat ggc cag aaa taa ctg        684
Pro Lys Lys Pro Gly Val Pro Cys Leu Ala Asp Gly Gln Lys     Leu           
190                 195                 200                               

cac tac ctt ccg ttt cca agt ccc gggaattcat cgtgactgac tgacgatctg       738
His Tyr Leu Pro Phe Pro Ser Pro                                           
205                 210                                                   

cctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt      798

cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcaggcgc gtcagcgggt      858

gttggcgggt gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtataaa      918

ttcttgaagr acg                                                         931


<210>  28
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn His Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Lys 
            180                 


<210>  29
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  29

Ala Arg Arg Thr Tyr Pro Lys Lys Pro Gly Val Pro Cys Leu Ala Asp 
1               5                   10                  15      


Gly Gln Lys 
            


<210>  30
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  30

Leu His Tyr Leu Pro Phe Pro Ser Pro 
1               5                   


<210>  31
<211>  924
<212>  DNA
<213>  Artificial sequence

<220>
<223>  USMREGDelta20, Clone #1


<220>
<221>  CDS
<222>  (57)..(836)

<400>  31
tsttacattt ccacaggaac agtattcatg gggctgaggg actggaaaca gtattc atg       59
                                                              Met         
                                                              1           

ggg ctg agg gac tgg ctg aga acc gtg tgc tgc tgc tgc ggg tgc gag        107
Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys Glu           
            5                   10                  15                    

tgc ttg gag gag cgc gcc ctg cct gag aag gag ccc ctc gtc agt gat        155
Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser Asp           
        20                  25                  30                        

aac aat cca tat tcc tca ttt gga gca act ctg gtg agg gat gat gag        203
Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp Glu           
    35                  40                  45                            

aag aat tta tgg agt atg ccc cat gat gtg tcc cac aca gag gca gac        251
Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala Asp           
50                  55                  60                  65            

gac gac aga acc ctg tac aat ttg ata gtc att cgt aat cag cag gcc        299
Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln Ala           
                70                  75                  80                

aaa gac tca gag gag tgg cag aag ctc aac tat gat atc cat acc ctg        347
Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr Leu           
            85                  90                  95                    

cgg cag gtt cga agg gaa gta aga aac aga tgg aag tgc atc tta gaa        395
Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu Glu           
        100                 105                 110                       

gat tta ggt ttt caa aag gaa gct gac tct ttg ttg tca gtg act aaa        443
Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr Lys           
    115                 120                 125                           

ctc agc acc atc agt gat tct aaa aac aca agg aaa gct cga gag atg        491
Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu Met           
130                 135                 140                 145           

ttg tta aaa ctg gct gaa gaa acc aat att ttc cca aca agt tgg gag        539
Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp Glu           
                150                 155                 160               

ctc tca gag aga tat ctc ttt gtt gtg gac cgt ctc att gca ctt gat        587
Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu Asp           
            165                 170                 175                   

gct gca gag gag ttc ttt aag ctt gct cgt cga act tac ccc aag aag        635
Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys Lys           
        180                 185                 190                       

ccc atg gtt cca tgc ctg gcc caa gaa gcc cat ggt tcc atg cct ggc        683
Pro Met Val Pro Cys Leu Ala Gln Glu Ala His Gly Ser Met Pro Gly           
    195                 200                 205                           

aga tgg cca gaa aga act gca cta cct tcc gtt tcc aag tcc cat ggc        731
Arg Trp Pro Glu Arg Thr Ala Leu Pro Ser Val Ser Lys Ser His Gly           
210                 215                 220                 225           

ccc tat act agg tta ttg gaa aat taa ggg cct tgt gca acc cac tcg        779
Pro Tyr Thr Arg Leu Leu Glu Asn     Gly Pro Cys Ala Thr His Ser           
                230                     235                 240           

act tct ttt gga ata tct tga aga aaa ata tga aga gca ttt gta tga        827
Thr Ser Phe Gly Ile Ser     Arg Lys Ile     Arg Ala Phe Val               
                245                         250                           

gcg cga tga agtgataatg gcgaaacaaa aagttgatgg ttggagttcc                876
Ala Arg                                                                   
    255                                                                   

atctctatat atgatggtga tgtaattaac acagtctatg gccatcat                   924


<210>  32
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys 
            180                 185                 190         


Lys Pro Met Val Pro Cys Leu Ala Gln Glu Ala His Gly Ser Met Pro 
        195                 200                 205             


Gly Arg Trp Pro Glu Arg Thr Ala Leu Pro Ser Val Ser Lys Ser His 
    210                 215                 220                 


Gly Pro Tyr Thr Arg Leu Leu Glu Asn 
225                 230             


<210>  33
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  33

Gly Pro Cys Ala Thr His Ser Thr Ser Phe Gly Ile Ser 
1               5                   10              


<210>  34
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  34

Arg Ala Phe Val 
1               


<210>  35
<211>  952
<212>  DNA
<213>  Artificial sequence

<220>
<223>  USMREGDelta30, cloine #1


<220>
<221>  CDS
<222>  (346)..(951)

<400>  35
tgttgatgaa agctggctac aggaaggccc agacgcgaat tatttttgat gcgtggaatt       60

agctatcgac tgcacggtgc accaatgctt ctggcgtcag gcagccatcg gaagctgtgg      120

tatggctgtg caggtcgtaa atcactgcat aattcgtgtc gctcaaggcg cactcccgtt      180

ctggataatg ttttttgcgc cgacatcata acggttctgg caaatattct gaaatgagct      240

gttgacaatt aatcatcggc tcgtataatg tgtggaattg tgagcggata acaatttcac      300

acaggaaaca gtattcatgg ggctgaggga ctggaaacag tattc atg ggg ctg agg      357
                                                  Met Gly Leu Arg         
                                                  1                       

gac tgg ctg aga acc gtg tgc tgc tgc tgc ggg tgc gag tgc ttg gag        405
Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys Glu Cys Leu Glu           
5                   10                  15                  20            

gag cgc gcc ctg cct gag aag gag ccc ctc gtc agt gat aac aat cca        453
Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser Asp Asn Asn Pro           
                25                  30                  35                

tat tcc tca ttt gga gca act ctg gtg agg gat gat gag aag aat tta        501
Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp Glu Lys Asn Leu           
            40                  45                  50                    

tgg agt atg ccc cat gat gtg tcc cac aca gag gca gac gac gac aga        549
Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala Asp Asp Asp Arg           
        55                  60                  65                        

acc ctg tac aat ttg ata gtc att cgt aat cag cag gcc aaa gac tca        597
Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln Ala Lys Asp Ser           
    70                  75                  80                            

gag gag tgg cag aag ctc aac tat gat atc cat acc ctg cgg cag gtt        645
Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr Leu Arg Gln Val           
85                  90                  95                  100           

cga agg gaa gta aga aac aga tgg aag tgc atc tta gaa gat tta ggt        693
Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu Glu Asp Leu Gly           
                105                 110                 115               

ttt caa aag gaa gct gac tct ttg ttg tca gtg act aaa ctc agc acc        741
Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr Lys Leu Ser Thr           
            120                 125                 130                   

atc agt gat tct aaa aac aca agg aaa gct cga gag atg ttg tta aaa        789
Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu Met Leu Leu Lys           
        135                 140                 145                       

ctg gct gaa gaa acc aat att ttc cca aca agt tgg gag ctc tca gag        837
Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp Glu Leu Ser Glu           
    150                 155                 160                           

aga tat ctc ttt gtt gtg gac cgt ctc att gca ctt gat gct gca gaa        885
Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu Asp Ala Ala Glu           
165                 170                 175                 180           

gag ttc ttt acc atg gcc cct ata cta ggt tat tgg aaa att aag ggc        933
Glu Phe Phe Thr Met Ala Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly           
                185                 190                 195               

ctg tgc aac cca ctc gaa t                                              952
Leu Cys Asn Pro Leu Glu                                                   
            200                                                           


<210>  36
<211>  202
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  36

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Thr Met Ala Pro Ile Leu Gly Tyr Trp 
            180                 185                 190         


Lys Ile Lys Gly Leu Cys Asn Pro Leu Glu 
        195                 200         


<210>  37
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DS MREG forward primer

<400>  37
gggctggcaa gccacgtttg gtg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DSMREGDelta 10 reverse primer

<400>  38
ccgggagctg catgtgtcag agg                                               23


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  US MREG forward primer

<400>  39
ycatcggctc gtataatgtg t                                                 21


<210>  40
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  US MREG reverse primer

<400>  40
ccgggagctg catgtgtcag agg                                               23


<210>  41
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mus musculus (N-terminal GFP) forward primer

<400>  41
agcttcccga ctaccact                                                     18


<210>  42
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mus musculus N-terminal GFP reverse primer

<400>  42
cagtgcagtt ttctctggc                                                    19


<210>  43
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  C-terminal GFP reverse primer

<400>  43
atcctggggc ttggaaat                                                     18


<210>  44
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  L90A mutation on mMREG


<220>
<221>  CDS
<222>  (1)..(642)

<400>  44
atg ggg ctg cgc cgc tgg cta cgg agc gcc tgc tgc tgc tgc ccg tgc         48
Met Gly Leu Arg Arg Trp Leu Arg Ser Ala Cys Cys Cys Cys Pro Cys           
1               5                   10                  15                

cgg tgc ctg gag gag ccc gcg cgg ccc gag aag gag ccg ctg gtc agt         96
Arg Cys Leu Glu Glu Pro Ala Arg Pro Glu Lys Glu Pro Leu Val Ser           
            20                  25                  30                    

ggt aac aat ccg tat tcc tcc ttt gga gcg act ctg gag agg gat gat        144
Gly Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Glu Arg Asp Asp           
        35                  40                  45                        

gag aag aat tta tgg agc atg cct cat gac gtg tcc cac aca gag gcg        192
Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala           
    50                  55                  60                            

gat gac gat agg atc ttg tat aat ttg ata gtc att cgt aat cag cag        240
Asp Asp Asp Arg Ile Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln           
65                  70                  75                  80            

acc aaa gac tca gag gaa tgg caa aga gcc aac tat gat atc tac acc        288
Thr Lys Asp Ser Glu Glu Trp Gln Arg Ala Asn Tyr Asp Ile Tyr Thr           
                85                  90                  95                

ctg cgg cag atc cgc agg gaa gtg agg aac cga tgg aga cga atc tta        336
Leu Arg Gln Ile Arg Arg Glu Val Arg Asn Arg Trp Arg Arg Ile Leu           
            100                 105                 110                   

gag gac ttg ggc ttt caa agg gaa gcc gac tct ctg ttg tca gtg acc        384
Glu Asp Leu Gly Phe Gln Arg Glu Ala Asp Ser Leu Leu Ser Val Thr           
        115                 120                 125                       

aaa ctc agc acc atg agt gat tct aaa aac aca agg aaa gcc cgg gag        432
Lys Leu Ser Thr Met Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu           
    130                 135                 140                           

atg ctg tta aag ctg gct gaa gag acc tct atc ttc ccc gcc agc tgg        480
Met Leu Leu Lys Leu Ala Glu Glu Thr Ser Ile Phe Pro Ala Ser Trp           
145                 150                 155                 160           

gag ctc tcc gag agg tac ctc ttg gtt gtg gac cgg ctc att gct ctc        528
Glu Leu Ser Glu Arg Tyr Leu Leu Val Val Asp Arg Leu Ile Ala Leu           
                165                 170                 175               

gat gct gct gag gac ttc ttt aag att gct agc caa atg tac ccc aag        576
Asp Ala Ala Glu Asp Phe Phe Lys Ile Ala Ser Gln Met Tyr Pro Lys           
            180                 185                 190                   

aaa cct ggg gtc cca tgc ctg gtg gac ggc cag aga aaa ctg cac tgc        624
Lys Pro Gly Val Pro Cys Leu Val Asp Gly Gln Arg Lys Leu His Cys           
        195                 200                 205                       

ctt cca ttt cca agc ccc                                                642
Leu Pro Phe Pro Ser Pro                                                   
    210                                                                   


<210>  45
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  45

Met Gly Leu Arg Arg Trp Leu Arg Ser Ala Cys Cys Cys Cys Pro Cys 
1               5                   10                  15      


Arg Cys Leu Glu Glu Pro Ala Arg Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Gly Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Glu Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Ile Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Thr Lys Asp Ser Glu Glu Trp Gln Arg Ala Asn Tyr Asp Ile Tyr Thr 
                85                  90                  95      


Leu Arg Gln Ile Arg Arg Glu Val Arg Asn Arg Trp Arg Arg Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Arg Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Met Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Ser Ile Phe Pro Ala Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Leu Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Asp Phe Phe Lys Ile Ala Ser Gln Met Tyr Pro Lys 
            180                 185                 190         


Lys Pro Gly Val Pro Cys Leu Val Asp Gly Gln Arg Lys Leu His Cys 
        195                 200                 205             


Leu Pro Phe Pro Ser Pro 
    210                 


<210>  46
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mus musculus GFP-MREG (W87A) forward rpimer

<400>  46
agcttcccga ctaccact                                                     18


<210>  47
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GFP-MREG (W87A) Clone #1010 Primers (N-terminal GFP):

<400>  47
cagtgcagtt ttctctggc                                                    19


<210>  48
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GFP-MREG C-terminal GFP reverse primer

<400>  48
atcctggggc ttggaaat                                                     18


<210>  49
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  W87A mutation on mMREG


<220>
<221>  CDS
<222>  (1)..(642)

<400>  49
atg ggg ctg cgc cgc tgg cta cgg agc gcc tgc tgc tgc tgc ccg tgc         48
Met Gly Leu Arg Arg Trp Leu Arg Ser Ala Cys Cys Cys Cys Pro Cys           
1               5                   10                  15                

cgg tgc ctg gag gag ccc gcg cgg ccc gag aag gag ccg ctg gtc agt         96
Arg Cys Leu Glu Glu Pro Ala Arg Pro Glu Lys Glu Pro Leu Val Ser           
            20                  25                  30                    

ggt aac aat ccg tat tcc tcc ttt gga gcg act ctg gag agg gat gat        144
Gly Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Glu Arg Asp Asp           
        35                  40                  45                        

gag aag aat tta tgg agc atg cct cat gac gtg tcc cac aca gag gcg        192
Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala           
    50                  55                  60                            

gat gac gat agg atc ttg tat aat ttg ata gtc att cgt aat cag cag        240
Asp Asp Asp Arg Ile Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln           
65                  70                  75                  80            

acc aaa gac tca gag gaa gcg caa aga ctc aac tat gat atc tac acc        288
Thr Lys Asp Ser Glu Glu Ala Gln Arg Leu Asn Tyr Asp Ile Tyr Thr           
                85                  90                  95                

ctg cgg cag atc cgc agg gaa gtg agg aac cga tgg aga cga atc tta        336
Leu Arg Gln Ile Arg Arg Glu Val Arg Asn Arg Trp Arg Arg Ile Leu           
            100                 105                 110                   

gag gac ttg ggc ttt caa agg gaa gcc gac tct ctg ttg tca gtg acc        384
Glu Asp Leu Gly Phe Gln Arg Glu Ala Asp Ser Leu Leu Ser Val Thr           
        115                 120                 125                       

aaa ctc agc acc atg agt gat tct aaa aac aca agg aaa gcc cgg gag        432
Lys Leu Ser Thr Met Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu           
    130                 135                 140                           

atg ctg tta aag ctg gct gaa gag acc tct atc ttc ccc gcc agc tgg        480
Met Leu Leu Lys Leu Ala Glu Glu Thr Ser Ile Phe Pro Ala Ser Trp           
145                 150                 155                 160           

gag ctc tcc gag agg tac ctc ttg gtt gtg gac cgg ctc att gct ctc        528
Glu Leu Ser Glu Arg Tyr Leu Leu Val Val Asp Arg Leu Ile Ala Leu           
                165                 170                 175               

gat gct gct gag gac ttc ttt aag att gct agc caa atg tac ccc aag        576
Asp Ala Ala Glu Asp Phe Phe Lys Ile Ala Ser Gln Met Tyr Pro Lys           
            180                 185                 190                   

aaa cct ggg gtc cca tgc ctg gtg gac ggc cag aga aaa ctg cac tgc        624
Lys Pro Gly Val Pro Cys Leu Val Asp Gly Gln Arg Lys Leu His Cys           
        195                 200                 205                       

ctt cca ttt cca agc ccc                                                642
Leu Pro Phe Pro Ser Pro                                                   
    210                                                                   


<210>  50
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  50

Met Gly Leu Arg Arg Trp Leu Arg Ser Ala Cys Cys Cys Cys Pro Cys 
1               5                   10                  15      


Arg Cys Leu Glu Glu Pro Ala Arg Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Gly Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Glu Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Ile Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Thr Lys Asp Ser Glu Glu Ala Gln Arg Leu Asn Tyr Asp Ile Tyr Thr 
                85                  90                  95      


Leu Arg Gln Ile Arg Arg Glu Val Arg Asn Arg Trp Arg Arg Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Arg Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Met Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Ser Ile Phe Pro Ala Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Leu Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Asp Phe Phe Lys Ile Ala Ser Gln Met Tyr Pro Lys 
            180                 185                 190         


Lys Pro Gly Val Pro Cys Leu Val Asp Gly Gln Arg Lys Leu His Cys 
        195                 200                 205             


Leu Pro Phe Pro Ser Pro 
    210                 


<210>  51
<211>  941
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DS MREGdelta@0 9pGEXhMREGdelta20, clone #6)


<220>
<221>  CDS
<222>  (255)..(896)

<400>  51
ggtgatcatt aagccatcat gacgtcagat gtatgctctt gatgtgttgt atacatgacc       60

catgtgcctg gatgcgtcca aatgttgttt aaaaaacgta ttgaagcttc cacaaattga      120

taagtacttg aatccagcaa gtatatagca tggcctttgc aggctggcaa gccacgtttg      180

gtggtgtgac catcatccaa aatcggatct ggttccggtg gatccccggg gctgagggac      240

tggaaacagt attc atg ggg ctg agg gac tgg ctg aga acc gtg tgc tgc        290
                Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys           
                1               5                   10                    

tgc tgc ggg tgc gag tgc ttg gag gag cgc gcc ctg cct gag aag gag        338
Cys Cys Gly Cys Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu           
        15                  20                  25                        

ccc ctc gtc agt gat aac aat cca tat tcc tca ttt gga gca act ctg        386
Pro Leu Val Ser Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu           
    30                  35                  40                            

gtg agg gat gat gag aag aat tta tgg agt atg ccc cat gat gtg tcc        434
Val Arg Asp Asp Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser           
45                  50                  55                  60            

cac aca gag gca gac gac gac aga acc ctg tac aat ttg ata gtc att        482
His Thr Glu Ala Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile           
                65                  70                  75                

cgt aat cag cag gcc aaa gac tca gag gag tgg cag aag ctc aac cat        530
Arg Asn Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn His           
            80                  85                  90                    

gat atc cat acc ctg cgg cag gtt cga agg gaa gta aga aac aga tgg        578
Asp Ile His Thr Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp           
        95                  100                 105                       

aag tgc atc tta gaa gat tta ggt ttt caa aag gaa gct gac tct ttg        626
Lys Cys Ile Leu Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu           
    110                 115                 120                           

ttg tca gtg act aaa ctc agc acc atc agt gat tct aaa aac aca agg        674
Leu Ser Val Thr Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg           
125                 130                 135                 140           

aaa gct cga gag atg ttg tta aaa ctg gct gaa gaa acc aat att ttc        722
Lys Ala Arg Glu Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe           
                145                 150                 155               

cca aca agt tgg gag ctc tca gag aga tat ctc ttt gtt gtg gac cgt        770
Pro Thr Ser Trp Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg           
            160                 165                 170                   

ctc att gca ctt gat gct gca gag gag ttc ttt aag ctt gct cgt cga        818
Leu Ile Ala Leu Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg           
        175                 180                 185                       

act tac ccc aag aag cct taa gtt cca tgc ctg gca gat ggc cag aaa        866
Thr Tyr Pro Lys Lys Pro     Val Pro Cys Leu Ala Asp Gly Gln Lys           
    190                     195                 200                       

taa ctg cac tac ctt ccg ttt cca agt ccc gggaattcat cgtgactgac          916
    Leu His Tyr Leu Pro Phe Pro Ser Pro                                   
        205                 210                                           

tgacgatctg cctcgcgcgt tcgaa                                            941


<210>  52
<211>  194
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn His Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys 
            180                 185                 190         


Lys Pro 
        


<210>  53
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  53

Val Pro Cys Leu Ala Asp Gly Gln Lys 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  54

Leu His Tyr Leu Pro Phe Pro Ser Pro 
1               5                   


<210>  55
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys 
            180                 185                 190         


Lys Pro Gly Val Pro Cys Leu Ala Asp Gly Gln Lys Glu Leu His Tyr 
        195                 200                 205             


Leu Pro Phe Pro Ser Pro 
    210                 


<210>  56
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys 
            180                 185                 190         


Lys Pro Gly Val Pro Cys Leu Ala Asp Gly Gln Lys Glu Leu His Leu 
        195                 200                 205             


Trp Gly Asp Leu Ser Cys Arg Leu Ala His Met Gln Gly Val Leu His 
    210                 215                 220                 


<210>  57
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered mutant MREG protein US Delta10

<400>  57

Cys Cys Cys Cys Gly Cys Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu 
1               5                   10                  15      


Lys Glu Pro Leu Val Ser Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala 
            20                  25                  30          


Thr Leu Val Arg Asp Asp Glu Lys Asn Leu Trp Ser Met Pro His Asp 
        35                  40                  45              


Val Ser His Thr Glu Ala Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile 
    50                  55                  60                  


Val Ile Arg Asn Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu 
65                  70                  75                  80  


Asn Tyr Asp Ile His Thr Leu Arg Gln Val Arg Arg Glu Val Arg Asn 
                85                  90                  95      


Arg Trp Lys Cys Ile Leu Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp 
            100                 105                 110         


Ser Leu Leu Ser Val Thr Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn 
        115                 120                 125             


Thr Arg Lys Ala Arg Glu Met Leu Leu Lys Leu Ala Glu Glu Thr Asn 
    130                 135                 140                 


Ile Phe Pro Thr Ser Trp Glu Leu Ser Glu Arg Tyr Leu Phe Val Val 
145                 150                 155                 160 


Asp Arg Leu Ile Ala Leu Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala 
                165                 170                 175     


Arg Arg Thr Tyr Pro Lys Lys Pro Gly Val Pro Cys Leu Ala Asp Gly 
            180                 185                 190         


Gln Lys Glu Leu His Tyr Leu Pro Phe Pro Ser Pro 
        195                 200                 


<210>  58
<211>  194
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered mutant MREG US Delta 20

<400>  58

Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser Asp Asn Asn Pro 
1               5                   10                  15      


Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp Glu Lys Asn Leu 
            20                  25                  30          


Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala Asp Asp Asp Arg 
        35                  40                  45              


Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln Ala Lys Asp Ser 
    50                  55                  60                  


Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr Leu Arg Gln Val 
65                  70                  75                  80  


Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu Glu Asp Leu Gly 
                85                  90                  95      


Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr Lys Leu Ser Thr 
            100                 105                 110         


Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu Met Leu Leu Lys 
        115                 120                 125             


Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp Glu Leu Ser Glu 
    130                 135                 140                 


Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu Asp Ala Ala Glu 
145                 150                 155                 160 


Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys Lys Pro Gly Val 
                165                 170                 175     


Pro Cys Leu Ala Asp Gly Gln Lys Glu Leu His Tyr Leu Pro Phe Pro 
            180                 185                 190         


Ser Pro 
        


<210>  59
<211>  194
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered mutant MREG US Delta 30

<400>  59

Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser Asp Asn Asn Pro 
1               5                   10                  15      


Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp Glu Lys Asn Leu 
            20                  25                  30          


Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala Asp Asp Asp Arg 
        35                  40                  45              


Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln Ala Lys Asp Ser 
    50                  55                  60                  


Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr Leu Arg Gln Val 
65                  70                  75                  80  


Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu Glu Asp Leu Gly 
                85                  90                  95      


Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr Lys Leu Ser Thr 
            100                 105                 110         


Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu Met Leu Leu Lys 
        115                 120                 125             


Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp Glu Leu Ser Glu 
    130                 135                 140                 


Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu Asp Ala Ala Glu 
145                 150                 155                 160 


Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys Lys Pro Gly Val 
                165                 170                 175     


Pro Cys Leu Ala Asp Gly Gln Lys Glu Leu His Tyr Leu Pro Phe Pro 
            180                 185                 190         


Ser Pro 
        


<210>  60
<211>  194
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered mutant MREG DS Delta 10

<400>  60

Cys Cys Cys Cys Gly Cys Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu 
1               5                   10                  15      


Lys Glu Pro Leu Val Ser Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala 
            20                  25                  30          


Thr Leu Val Arg Asp Asp Glu Lys Asn Leu Trp Ser Met Pro His Asp 
        35                  40                  45              


Val Ser His Thr Glu Ala Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile 
    50                  55                  60                  


Val Ile Arg Asn Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu 
65                  70                  75                  80  


Asn Tyr Asp Ile His Thr Leu Arg Gln Val Arg Arg Glu Val Arg Asn 
                85                  90                  95      


Arg Trp Lys Cys Ile Leu Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp 
            100                 105                 110         


Ser Leu Leu Ser Val Thr Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn 
        115                 120                 125             


Thr Arg Lys Ala Arg Glu Met Leu Leu Lys Leu Ala Glu Glu Thr Asn 
    130                 135                 140                 


Ile Phe Pro Thr Ser Trp Glu Leu Ser Glu Arg Tyr Leu Phe Val Val 
145                 150                 155                 160 


Asp Arg Leu Ile Ala Leu Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala 
                165                 170                 175     


Arg Arg Thr Tyr Pro Lys Lys Pro Gly Val Pro Cys Leu Ala Asp Gly 
            180                 185                 190         


Gln Lys 
        


<210>  61
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered mutant MREG DS Delta 20

<400>  61

Cys Cys Cys Cys Gly Cys Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu 
1               5                   10                  15      


Lys Glu Pro Leu Val Ser Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala 
            20                  25                  30          


Thr Leu Val Arg Asp Asp Glu Lys Asn Leu Trp Ser Met Pro His Asp 
        35                  40                  45              


Val Ser His Thr Glu Ala Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile 
    50                  55                  60                  


Val Ile Arg Asn Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu 
65                  70                  75                  80  


Asn Tyr Asp Ile His Thr Leu Arg Gln Val Arg Arg Glu Val Arg Asn 
                85                  90                  95      


Arg Trp Lys Cys Ile Leu Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp 
            100                 105                 110         


Ser Leu Leu Ser Val Thr Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn 
        115                 120                 125             


Thr Arg Lys Ala Arg Glu Met Leu Leu Lys Leu Ala Glu Glu Thr Asn 
    130                 135                 140                 


Ile Phe Pro Thr Ser Trp Glu Leu Ser Glu Arg Tyr Leu Phe Val Val 
145                 150                 155                 160 


Asp Arg Leu Ile Ala Leu Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala 
                165                 170                 175     


Arg Arg Thr Tyr Pro Lys Lys Pro 
            180                 


<210>  62
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered mutant MREG DS Delta 30

<400>  62

Cys Cys Cys Cys Gly Cys Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu 
1               5                   10                  15      


Lys Glu Pro Leu Val Ser Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala 
            20                  25                  30          


Thr Leu Val Arg Asp Asp Glu Lys Asn Leu Trp Ser Met Pro His Asp 
        35                  40                  45              


Val Ser His Thr Glu Ala Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile 
    50                  55                  60                  


Val Ile Arg Asn Gln Gln Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu 
65                  70                  75                  80  


Asn Tyr Asp Ile His Thr Leu Arg Gln Val Arg Arg Glu Val Arg Asn 
                85                  90                  95      


Arg Trp Lys Cys Ile Leu Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp 
            100                 105                 110         


Ser Leu Leu Ser Val Thr Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn 
        115                 120                 125             


Thr Arg Lys Ala Arg Glu Met Leu Leu Lys Leu Ala Glu Glu Thr Asn 
    130                 135                 140                 


Ile Phe Pro Thr Ser Trp Glu Leu Ser Glu Arg Tyr Leu Phe Val Val 
145                 150                 155                 160 


Asp Arg Leu Ile Ala Leu Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala 
                165                 170                 175     


Arg Arg Thr Tyr Pro Lys Lys Pro 
            180                 


