                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       UNIVERSITY OF MARYLAND, COLLEGE PARK
 
<120>  IL-7R-ALPHA SPECIFIC ANTIBODIES FOR TREATING ACUTE LYMPHOBLASTIC 
       LEUKEMIA

<130>  4239-95739-02

<150>  US62/238,612
<151>  2015-10-07

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  1

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Asp Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Leu Tyr Ser Asn Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Val Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Asp Asn Gly Gly Asn Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Asp Gly Ser Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  4

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Leu Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Thr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ile Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  5

Ser Tyr Trp Met His 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  6

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Asp Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  7

Arg Leu Tyr Ser Asn Ser Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  8

Lys Ala Ser Gln Asp Ile Lys Lys Tyr Ile Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  9

Tyr Thr Ser Thr Leu Gln Pro 
1               5           


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  10

Leu Gln Tyr Asp Asn Leu Leu Thr 
1               5               


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  11

Asp Tyr Tyr Met His 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  12

Tyr Ile Tyr Pro Asp Asn Gly Gly Asn Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  13

Gly Thr Tyr Tyr Asp Gly Ser Tyr Phe Asp Tyr 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  14

Lys Ala Ser Gln Asp Val Ser Thr Thr Val Ala 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  15

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  16

Gln Gln His Tyr Ser Ile Pro Arg Thr 
1               5                   


<210>  17
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  17

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Asp Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Leu Tyr Ser Asn Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asn Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  18
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Val Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Arg Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Asn Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  19
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  19

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Asp Asn Gly Gly Asn Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Asp Gly Ser Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
            180                 185                 190         


Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
    210                 215                 220                 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
    290                 295                 300                 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
305                 310                 315                 320 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
            340                 345                 350         


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asn 
        355                 360                 365             


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
    370                 375                 380                 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
385                 390                 395                 400 


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
                405                 410                 415     


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
            420                 425                 430         


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 


<210>  20
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  20

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Leu Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Thr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ile Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Arg Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  21
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  21

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Asp Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Leu Tyr Ser Asn Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  22
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Val Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  23
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  23

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Asp Asn Gly Gly Asn Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Asp Gly Ser Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  24
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  24

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Leu Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Thr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ile Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  25
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  25
caggtccaac tgcagcagcc tggggctgag cttgtgatgc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggagaag gccttgagtg gatcggagag attgatcctt ctgatagtta tactaacgac      180

aatcaaaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagaaggctc      300

tatagtaact cttattacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  26
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  26
gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc       60

atcacttgca aggcaagcca agacattaag aagtatatag cttggtacca acacaagcct      120

ggaaaaggtc ctaggctgct catacattac acatctacat tacagccagg catcccatca      180

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      240

gtggatattg caacttatta ttgtctgcag tatgataatc ttctcacatt cggtgctggg      300

accaagctgg agctgaaa                                                    318


<210>  27
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  27
gaggtccagc tgcaacagtc tggacctgag ttggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta cacattcagt gactactaca tgcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat atttatcctg acaatggtgg taatggctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagtctac      240

atggagctcc gcagcctgac atctgaggac tctgcactct attactgtgc aagagggacc      300

tactatgatg gttcctactt tgactactgg ggccaaggca ccactctcac agtctcctca      360


<210>  28
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  28
gacattgtga tgacccagtc tcacaaattc atgtccacat tagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgagt actactgtag cctggtatca acagaaacca      120

ggacaatctc ctaaactact gatttactcg gcatcctacc ggtacactgg agtccctgat      180

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      240

gaagacctgg cagtttatta ctgtcaacaa cattatagta ttcctcggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  29
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  29
caggtccaac tgcagcagcc tggggctgag cttgtgatgc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggagaag gccttgagtg gatcggagag attgatcctt ctgatagtta tactaacgac      180

aatcaaaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagaaggctc      300

tatagtaact cttattacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctcagcca aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa      420

actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca      480

gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag      540

tctgacctct acactctgag cagctcagtg actgtcccct ccagcacctg gcccagccag      600

accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg      660

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      720

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      780

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      840

gtggaggtgc acacagctca gacgaaaccc cgggaggagc agatcaacag cactttccgt      900

tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc      960

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc     1020

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat     1080

aaagtcagtc tgacctgcat gataacaaac ttcttccctg aagacattac tgtggagtgg     1140

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat     1200

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat     1260

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc     1320

tcccactctc ctggtaaa                                                   1338


<210>  30
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  30
gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc       60

atcacttgca aggcaagcca agacattaag aagtatatag cttggtacca acacaagcct      120

ggaaaaggtc ctaggctgct catacattac acatctacat tacagccagg catcccatca      180

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      240

gtggatattg caacttatta ttgtctgcag tatgataatc ttctcacatt cggtgctggg      300

accaagctgg agctgaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc      360

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      420

agagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg tgtcctgaac      480

agttggactg atcaggacag caaagacagc acctacaaca tgagcagcac cctcacattg      540

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca      600

acttcaccca tcgtcaagag cttcaacagg aatgagtgt                             639


<210>  31
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  31
gaggtccagc tgcaacagtc tggacctgag ttggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta cacattcagt gactactaca tgcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat atttatcctg acaatggtgg taatggctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagtctac      240

atggagctcc gcagcctgac atctgaggac tctgcactct attactgtgc aagagggacc      300

tactatgatg gttcctactt tgactactgg ggccaaggca ccactctcac agtctcctca      360

gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac      420

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc      480

tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac      540

ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag ccagaccgtc      600

acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg      660

gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc      720

cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg      780

gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag      840

gtgcacacag ctcagacgaa accccgggag gagcagatca acagcacttt ccgttcagtc      900

agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc      960

aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg     1020

aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc     1080

agtctgacct gcatgataac aaacttcttc cctgaagaca ttactgtgga gtggcagtgg     1140

aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct     1200

tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc     1260

acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac     1320

tctcctggta aa                                                         1332


<210>  32
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  32
gacattgtga tgacccagtc tcacaaattc atgtccacat tagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgagt actactgtag cctggtatca acagaaacca      120

ggacaatctc ctaaactact gatttactcg gcatcctacc ggtacactgg agtccctgat      180

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      240

gaagacctgg cagtttatta ctgtcaacaa cattatagta ttcctcggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccagagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggtgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcaca      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccatcgtcaa gagcttcaac aggaatgagt gt                         642


<210>  33
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  33
caggtccagc tgcagcagcc cggagccgaa ctggtcatgc ccggcgccag cgtgaagctg       60

tcctgcaagg cttctggcta taccttcaca tcctactgga tgcactgggt gaagcagaga      120

cccggagagg gactggagtg gatcggcgag atcgacccat ccgattctta taccaacgac      180

aatcagaagt ttaagggcaa ggccaccctg acagtggata agagctcctc taccgcttat      240

atgcagctga gctccctgac aagcgaggac tccgccgtgt actattgcgc tcggaggctg      300

tatagcaact cctactatta cgccatggat tactggggcc agggcaccag cgtgacagtg      360

tctagcgcca gcaccaaggg cccttccgtg ttcccactgg ctccctcctc taaatctacc      420

agcggaggaa cagccgctct gggatgtctg gtgaaggact acttcccaga gcccgtgaca      480

gtgtcttgga acagcggcgc cctgacctcc ggcgtgcaca catttcctgc tgtgctgcag      540

agctccggcc tgtattctct gtctagcgtg gtgaccgtgc catcctctag cctgggcacc      600

cagacataca tctgcaacgt gaatcacaag ccatccaata caaaggtgga caagaaggtc      660

gagcccaagt cttgtgataa gacccacaca tgcccccctt gtcctgctcc agagctgctg      720

ggaggacctt ccgtgttcct gtttccaccc aaacctaagg acaccctgat gatcagccgg      780

accccagagg tgacatgcgt ggtggtggac gtgtcccacg aggatcccga ggtgaagttt      840

aactggtacg tcgatggcgt ggaggtgcac aatgctaaga ccaagcccag agaggagcag      900

tataactcta cctaccgggt ggtgagcgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaggagt acaagtgcaa ggtgtctaat aaggccctgc ccgctcccat cgagaagacc     1020

atcagcaagg ccaagggcca gcctagggag ccacaggtgt atacactgcc tccatctaga     1080

gacgagctga ccaagaacca ggtgagcctg acatgtctgg tgaagggctt ctaccccagc     1140

gatatcgccg tggagtggga gtccaatggc cagcctgaga acaattataa gaccacaccc     1200

cctgtgctgg actccgatgg ctctttcttt ctgtactcca agctgaccgt ggataagtct     1260

aggtggcagc agggcaacgt gttcagctgt tctgtgatgc acgaagctct gcataatcac     1320

tacacccaga aaagcctgtc cctgtcacct ggtaaa                               1356


<210>  34
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  34
gatattcaga tgactcagtc cccttcttca ctgtctgcca gcctgggcgg caaggtgacc       60

atcacatgca aggcctccca ggacatcaag aagtacatcg cttggtatca gcacaagcct      120

ggcaagggcc cacggctgct gatccactac acctctacac tgcagccagg catccccagc      180

cggttctccg gaagcggaag cggaagggat tactcctttt ctatcagcaa cctggagccc      240

gtggacatcg ccacctacta ttgcctgcag tatgataatc tgctgacctt cggcgctggc      300

acaaagctgg agctgaagag aaccgtggcc gctcccagcg tgttcatctt tcccccttcc      360

gacgagcagc tgaagtccgg cacagcttct gtggtgtgcc tgctgaacaa cttctaccct      420

cgggaggcca aggtgcagtg gaaggtggat aacgctctgc agtccggcaa ttctcaggag      480

agcgtgaccg agcaggactc caaggattct acatatagcc tgagctccac cctgacactg      540

tctaaggccg actacgagaa gcacaaggtg tatgcttgtg aagtgactca tcagggtctg      600

tcatcacccg tgactaaatc attcaataga ggcgaatgc                             639


<210>  35
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  35
gaagtccagc tgcagcagtc tggtcctgaa ctggtgaagc ctggcgcctc cgtgaagatg       60

tcttgcaagg ctagcggcta caccttcagc gactactata tgcactgggt gaagcagtcc      120

cacggcaagt ctctggagtg gatcggctac atctatccag ataacggcgg caatggctac      180

aaccagaagt ttaagggcaa ggccaccctg acagtggaca agagctcctc taccgtgtat      240

atggagctga ggagcctgac atccgaggat tctgccctgt actattgcgc tagaggcacc      300

tactatgacg gctcctactt cgattattgg ggccagggca ccacactgac cgtgagctcc      360

gccagcacaa agggcccctc cgtgtttcca ctggctccct cttccaagtc taccagcgga      420

ggaacagccg ctctgggatg tctggtgaag gactacttcc cagagcccgt gaccgtgagc      480

tggaacagcg gcgccctgac ctccggcgtg cacacatttc cagctgtgct gcagtcctct      540

ggcctgtact ctctgagctc cgtggtgacc gtgccctcta gctccctggg cacccagaca      600

tatatctgca acgtgaatca caagccatcc aacacaaagg tggacaagaa ggtcgagccc      660

aagtcttgtg ataagaccca cacatgcccc ccttgtcctg ctcccgagct gctgggagga      720

cctagcgtgt tcctgtttcc acccaagcct aaggacaccc tgatgatcag ccggaccccc      780

gaggtgacat gcgtggtggt ggacgtgtcc cacgaggatc ctgaggtgaa gttcaattgg      840

tatgtcgatg gcgtggaggt gcacaacgct aagacaaagc ctcgggagga gcagtacaat      900

tctacctata gggtggtgag cgtgctgaca gtgctgcacc aggactggct caatggcaag      960

gagtataagt gcaaggtgtc taacaaggcc ctgcccgctc ctatcgagaa gaccatcagc     1020

aaggccaagg gccagcctag agagccacag gtgtacacac tgcctccatc tcgggacgag     1080

ctgaccaaga atcaggtgag cctgacatgt ctggtgaagg gcttctatcc tagcgatatc     1140

gccgtggagt gggagtccaa cggccagcca gagaacaatt acaagaccac accccctgtg     1200

ctggactctg atggcagctt ctttctgtat tccaagctga ccgtggataa gtctaggtgg     1260

cagcagggca acgtgttttc ctgttctgtg atgcacgaag ccctgcataa tcactatact     1320

cagaaatccc tgtcactgtc acctggtaaa                                      1350


<210>  36
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  36
gacattgtga tgactcagtc ccataaattc atgtctaccc tggtgggcga ccgggtgagc       60

atcacatgca aggcctctca ggatgtgagc accacagtgg cttggtacca gcagaagcca      120

ggccagtccc ccaagctgct gatctattcc gcctcttatc ggtataccgg agtgcctgac      180

aggttcaccg gaagcggatc cggcacagat ttcaccttta caatcagctc cgtgcaggcc      240

gaggacctgg ccgtgtacta ttgccagcag cactactcta tccctagaac ctttggcggc      300

ggcacaaagc tggagatcaa gcggaccgtg gccgctccaa gcgtgttcat ctttccccct      360

tccgacgagc agctgaagtc cggcacagct tctgtggtgt gcctgctgaa caatttctac      420

cccagggagg ccaaggtcca gtggaaggtg gataacgctc tgcagtctgg caatagccag      480

gagtccgtga ccgagcagga ctctaaggat agcacatatt ccctgtctag caccctgaca      540

ctgagcaagg ccgattacga gaagcacaag gtgtatgctt gtgaagtcac tcatcagggt      600

ctgtcttcac ctgtcactaa gtcttttaac cgaggcgaat gc                         642


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  37

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  38
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  38

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr 
            20          


<210>  39
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  39

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235     


<210>  40
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  40

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  41
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  41

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg 
65          


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  42

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  43
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  43

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  44
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  44

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  45
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  45

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  46
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric antigen receptor sequence

<400>  46

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  47

Gly Gly Gly Gly Ser 
1               5   


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  48

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  49

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


