                         SEQUENCE LISTING

<110>  REGENTS OF THE UNIVERSITY OF MINNESOTA
       Vallera, Daniel
       Miller, Jeffrey
 
<120>  THERAPEUTIC COMPOUNDS AND METHODS

<130>  110.04990201

<150>  US 62/237,835
<151>  2015-10-06

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  623
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  1

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
                245                 250                 255     


Asn His Ala Tyr Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        275                 280                 285             


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    290                 295                 300                 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
305                 310                 315                 320 


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
                325                 330                 335     


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            340                 345                 350         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        355                 360                 365             


Met Phe Ile Asn Thr Ser Glu Ala Ser Gly Gly Pro Glu Gln Val Gln 
    370                 375                 380                 


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
385                 390                 395                 400 


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met His 
                405                 410                 415     


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
            420                 425                 430         


Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys Ser Lys 
        435                 440                 445             


Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr Met Glu Leu 
    450                 455                 460                 


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
465                 470                 475                 480 


Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
        515                 520                 525             


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
    530                 535                 540                 


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
545                 550                 555                 560 


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
                565                 570                 575     


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
            580                 585                 590         


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
        595                 600                 605             


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    610                 615                 620             


<210>  2
<211>  502
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  2

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
                245                 250                 255     


Asn His Ala Tyr Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            260                 265                 270         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        275                 280                 285             


Phe Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    290                 295                 300                 


Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr 
305                 310                 315                 320 


Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr 
                325                 330                 335     


Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln 
            420                 425                 430         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn 
        435                 440                 445             


Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly 
                485                 490                 495     


Thr Lys Val Glu Ile Lys 
            500         


<210>  3
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  3

Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
1               5                   10                  15      


Asn His Ala Tyr 
            20  


<210>  4
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  4

Glu Ala Ser Gly Gly Pro Glu 
1               5           


<210>  5
<211>  596
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  5

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
                245                 250                 255     


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            260                 265                 270         


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        275                 280                 285             


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    290                 295                 300                 


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
305                 310                 315                 320 


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                325                 330                 335     


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            340                 345                 350         


Thr Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
        355                 360                 365             


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
    370                 375                 380                 


Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
385                 390                 395                 400 


Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln 
                405                 410                 415     


Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr 
            420                 425                 430         


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
        435                 440                 445             


Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr 
    450                 455                 460                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
                485                 490                 495     


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu 
            500                 505                 510         


Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys 
        515                 520                 525             


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly 
    530                 535                 540                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
545                 550                 555                 560 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
                565                 570                 575     


Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys 
            580                 585                 590         


Val Glu Ile Lys 
        595     


<210>  6
<211>  624
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  6

Met Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
1               5                   10                  15      


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
            20                  25                  30          


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
        35                  40                  45              


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
    50                  55                  60                  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly 
65                  70                  75                  80  


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
                85                  90                  95      


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
            100                 105                 110         


Ile Asn Thr Ser Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser 
        115                 120                 125             


Leu Phe Val Ser Asn His Ala Tyr Glu Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp Asn Gly Gly 
            180                 185                 190         


Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ser Leu Leu Phe 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr 
            260                 265                 270         


Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 
        275                 280                 285             


Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg 
305                 310                 315                 320 


Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
                325                 330                 335     


Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 
            340                 345                 350         


Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly 
        355                 360                 365             


Gly Thr Lys Leu Thr Val Leu Glu Ala Ser Gly Gly Pro Glu Gln Val 
    370                 375                 380                 


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
385                 390                 395                 400 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met 
                405                 410                 415     


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
            420                 425                 430         


Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys Ser 
        435                 440                 445             


Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr Met Glu 
    450                 455                 460                 


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
465                 470                 475                 480 


Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
        515                 520                 525             


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn 
    530                 535                 540                 


Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala 
545                 550                 555                 560 


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro 
                565                 570                 575     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            580                 585                 590         


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
        595                 600                 605             


Lys Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    610                 615                 620                 


<210>  7
<211>  623
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  7

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
                245                 250                 255     


Asn His Ala Tyr Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            260                 265                 270         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        275                 280                 285             


Phe Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    290                 295                 300                 


Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr 
305                 310                 315                 320 


Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr 
                325                 330                 335     


Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln 
            420                 425                 430         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn 
        435                 440                 445             


Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly 
                485                 490                 495     


Thr Lys Val Glu Ile Lys Glu Ala Ser Gly Gly Pro Glu Asn Trp Val 
            500                 505                 510         


Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
        515                 520                 525             


His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
    530                 535                 540                 


Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
545                 550                 555                 560 


Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
                565                 570                 575     


Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
            580                 585                 590         


Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
        595                 600                 605             


Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620             


<210>  8
<211>  634
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  8

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
                245                 250                 255     


Asn His Ala Tyr Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        275                 280                 285             


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    290                 295                 300                 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
305                 310                 315                 320 


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
                325                 330                 335     


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            340                 345                 350         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        355                 360                 365             


Met Phe Ile Asn Thr Ser Glu Ala Ser Gly Gly Pro Glu Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser Asn Gly Ile 
                405                 410                 415     


Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            420                 425                 430         


Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
        435                 440                 445             


Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    450                 455                 460                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn Leu Glu Ile 
465                 470                 475                 480 


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Ala Thr 
                485                 490                 495     


Pro Ser His Asn Ser His Gln Val Pro Ser Ala Gly Gly Pro Thr Ala 
            500                 505                 510         


Asn Ser Gly Thr Ser Gly Glu Val Gln Leu Val Gln Ser Gly Pro Gly 
        515                 520                 525             


Leu Val Gln Pro Gly Gly Ser Val Arg Ile Ser Cys Ala Ala Ser Gly 
    530                 535                 540                 


Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
545                 550                 555                 560 


Lys Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser 
                565                 570                 575     


Thr Tyr Ala Asp Ser Phe Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr 
            580                 585                 590         


Ser Ala Ser Ala Ala Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp 
        595                 600                 605             


Thr Ala Val Tyr Tyr Cys Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp 
    610                 615                 620                 


Gly Gln Gly Thr Leu Leu Thr Val Ser Ser 
625                 630                 


<210>  9
<211>  901
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  9

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
                245                 250                 255     


Asn His Ala Tyr Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        275                 280                 285             


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    290                 295                 300                 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
305                 310                 315                 320 


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
                325                 330                 335     


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            340                 345                 350         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        355                 360                 365             


Met Phe Ile Asn Thr Ser Glu Ala Ser Gly Gly Pro Glu Asp Ile Gln 
    370                 375                 380                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
385                 390                 395                 400 


Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser Asn Gly Ile 
                405                 410                 415     


Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            420                 425                 430         


Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
        435                 440                 445             


Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    450                 455                 460                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn Leu Glu Ile 
465                 470                 475                 480 


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Ala Thr 
                485                 490                 495     


Pro Ser His Asn Ser His Gln Val Pro Ser Ala Gly Gly Pro Thr Ala 
            500                 505                 510         


Asn Ser Gly Thr Ser Gly Glu Val Gln Leu Val Gln Ser Gly Pro Gly 
        515                 520                 525             


Leu Val Gln Pro Gly Gly Ser Val Arg Ile Ser Cys Ala Ala Ser Gly 
    530                 535                 540                 


Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
545                 550                 555                 560 


Lys Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser 
                565                 570                 575     


Thr Tyr Ala Asp Ser Phe Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr 
            580                 585                 590         


Ser Ala Ser Ala Ala Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp 
        595                 600                 605             


Thr Ala Val Tyr Tyr Cys Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp 
    610                 615                 620                 


Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Glu Pro Lys Ser Ser Asp 
625                 630                 635                 640 


Lys Thr His Thr Ser Pro Pro Ser Pro Asp Ile Val Leu Ser Gln Ser 
                645                 650                 655     


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Ser Cys 
            660                 665                 670         


Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro 
        675                 680                 685             


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser 
    690                 695                 700                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
705                 710                 715                 720 


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
                725                 730                 735     


Gln Gln Tyr His Ser Tyr Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu 
            740                 745                 750         


Glu Leu Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
        755                 760                 765             


Ser Ser Arg Ser Ser Leu Glu Val Lys Leu Val Glu Ser Gly Pro Glu 
    770                 775                 780                 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
785                 790                 795                 800 


Tyr Thr Phe Thr Asp Tyr Ser Met His Trp Val Asn Gln Ala Pro Gly 
                805                 810                 815     


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro 
            820                 825                 830         


Ser Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
        835                 840                 845             


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
    850                 855                 860                 


Thr Ala Thr Tyr Phe Cys Ala Thr Asp Tyr Gly Asp Tyr Phe Asp Tyr 
865                 870                 875                 880 


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro 
                885                 890                 895     


Pro Ser Val Thr Ser 
            900     


<210>  10
<211>  623
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  10

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
                245                 250                 255     


Asn His Ala Tyr Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        275                 280                 285             


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    290                 295                 300                 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
305                 310                 315                 320 


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
                325                 330                 335     


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            340                 345                 350         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        355                 360                 365             


Met Phe Ile Asn Thr Ser Glu Ala Ser Gly Gly Pro Glu Asp Ile Val 
    370                 375                 380                 


Leu Ser Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val 
385                 390                 395                 400 


Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr 
                405                 410                 415     


Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Arg Thr Ser 
            420                 425                 430         


Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        435                 440                 445             


Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala 
    450                 455                 460                 


Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Pro Thr Phe Gly Ala 
465                 470                 475                 480 


Gly Thr Lys Leu Glu Leu Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Gly Gly Ser Ser Arg Ser Ser Leu Glu Val Lys Leu Val Glu 
            500                 505                 510         


Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys 
        515                 520                 525             


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Ser Met His Trp Val Asn 
    530                 535                 540                 


Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu 
545                 550                 555                 560 


Thr Gly Glu Pro Ser Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe 
                565                 570                 575     


Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu 
            580                 585                 590         


Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Thr Asp Tyr Gly Asp 
        595                 600                 605             


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    610                 615                 620             


<210>  11
<211>  621
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  11

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
                245                 250                 255     


Asn His Ala Tyr Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        275                 280                 285             


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    290                 295                 300                 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
305                 310                 315                 320 


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
                325                 330                 335     


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            340                 345                 350         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        355                 360                 365             


Met Phe Ile Asn Thr Ser Glu Ala Ser Gly Gly Pro Glu Gln Val Gln 
    370                 375                 380                 


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
385                 390                 395                 400 


Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
                405                 410                 415     


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Leu Ile 
            420                 425                 430         


Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys 
        435                 440                 445             


Ala Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu 
    450                 455                 460                 


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
465                 470                 475                 480 


Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                485                 490                 495     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly 
            500                 505                 510         


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        515                 520                 525             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
    530                 535                 540                 


Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu 
545                 550                 555                 560 


Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
                565                 570                 575     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
            580                 585                 590         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His 
        595                 600                 605             


Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
    610                 615                 620     


<210>  12
<211>  1040
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  12

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 
                245                 250                 255     


Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
            260                 265                 270         


Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
        275                 280                 285             


Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
    290                 295                 300                 


Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
305                 310                 315                 320 


Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val Thr 
                325                 330                 335     


Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
            340                 345                 350         


Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
        355                 360                 365             


Ser Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val 
    370                 375                 380                 


Ser Asn His Ala Tyr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
385                 390                 395                 400 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys 
                405                 410                 415     


Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Ala Gln Asn Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr 
                485                 490                 495     


Lys Val Glu Leu Lys Arg Ala Thr Pro Ser His Asn Ser His Gln Val 
            500                 505                 510         


Pro Ser Ala Gly Gly Pro Thr Ala Asn Ser Gly Thr Ser Gly Glu Ala 
        515                 520                 525             


Ser Gly Gly Pro Glu Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
    530                 535                 540                 


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
545                 550                 555                 560 


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
                565                 570                 575     


Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro 
            580                 585                 590         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
        595                 600                 605             


Ser Asn Leu Glu Gln Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly 
    610                 615                 620                 


Asn Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
625                 630                 635                 640 


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
                645                 650                 655     


Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro 
            660                 665                 670         


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser 
        675                 680                 685             


Ile Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu 
    690                 695                 700                 


Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr Tyr Pro Asp 
705                 710                 715                 720 


Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                725                 730                 735     


Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr 
            740                 745                 750         


Tyr Cys Ala Arg His Ser Gly Tyr Gly Thr His Trp Gly Val Leu Phe 
        755                 760                 765             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    770                 775                 780                 


Gly Ser Asp Ile Leu Leu Thr Gln Thr Pro Ala Ser Leu Ala Val Ser 
785                 790                 795                 800 


Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp 
                805                 810                 815     


Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln 
            820                 825                 830         


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile 
        835                 840                 845             


Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn 
    850                 855                 860                 


Ile His Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln 
865                 870                 875                 880 


Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
                885                 890                 895     


Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
            900                 905                 910         


Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
        915                 920                 925             


Arg Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
    930                 935                 940                 


Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly 
945                 950                 955                 960 


Leu Glu Trp Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr 
                965                 970                 975     


Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser 
            980                 985                 990         


Ser Thr Ala Tyr Met Gln Leu Ser  Ser Leu Ala Ser Glu  Asp Ser Ala 
        995                 1000                 1005             


Val Tyr  Phe Cys Ala Arg Arg  Glu Thr Thr Thr Val  Gly Arg Tyr 
    1010                 1015                 1020             


Tyr Tyr  Ala Met Asp Tyr Trp  Gly Gln Gly Thr Ser  Val Thr Val 
    1025                 1030                 1035             


Ser Ser  
    1040 


<210>  13
<211>  661
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  13

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Arg Glu 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Thr 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Ser Ser Pro Ser Gly Gln Ala Gly Ala 
                245                 250                 255     


Ala Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr Pro Thr Ser 
            260                 265                 270         


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
        275                 280                 285             


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
    290                 295                 300                 


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
305                 310                 315                 320 


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
                325                 330                 335     


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
            340                 345                 350         


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
        355                 360                 365             


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
    370                 375                 380                 


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
385                 390                 395                 400 


Thr Glu Ala Ser Gly Gly Pro Glu Asp Ile Gln Met Thr Gln Ser Pro 
                405                 410                 415     


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
            420                 425                 430         


Ser Thr Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gln Met 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Ser Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Ala Gln Asn Leu Glu Ile Pro Arg Thr Phe Gly 
            500                 505                 510         


Gln Gly Thr Lys Val Glu Leu Lys Arg Ala Thr Pro Ser His Asn Ser 
        515                 520                 525             


His Gln Val Pro Ser Ala Gly Gly Pro Thr Ala Asn Ser Gly Thr Ser 
    530                 535                 540                 


Gly Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly 
545                 550                 555                 560 


Gly Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn 
                565                 570                 575     


Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            580                 585                 590         


Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser 
        595                 600                 605             


Phe Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala 
    610                 615                 620                 


Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
625                 630                 635                 640 


Cys Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
                645                 650                 655     


Leu Thr Val Ser Ser 
            660     


<210>  14
<211>  539
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  14

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser 
        35                  40                  45              


Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Ala Val Ala Ser Ile Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Asn Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
                165                 170                 175     


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
            180                 185                 190         


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
        195                 200                 205             


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
    210                 215                 220                 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
225                 230                 235                 240 


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
                245                 250                 255     


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
            260                 265                 270         


Ile Asn Thr Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
        275                 280                 285             


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
    290                 295                 300                 


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
305                 310                 315                 320 


Tyr Thr Phe Thr Asp Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr 
            340                 345                 350         


Gly Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu 
        355                 360                 365             


Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp 
385                 390                 395                 400 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
            420                 425                 430         


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
        435                 440                 445             


Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp 
    450                 455                 460                 


Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
465                 470                 475                 480 


Ser Asn Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                485                 490                 495     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe 
            500                 505                 510         


Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly 
        515                 520                 525             


Gln Gly Thr Lys Val Glu Ile Lys Val Asp Glu 
    530                 535                 


<210>  15
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  15

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  16
<211>  623
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  16

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
                245                 250                 255     


Asn His Ala Tyr Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        275                 280                 285             


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    290                 295                 300                 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
305                 310                 315                 320 


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
                325                 330                 335     


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            340                 345                 350         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        355                 360                 365             


Met Phe Ile Asn Thr Ser Glu Ala Ser Gly Gly Pro Glu Ala Lys Val 
    370                 375                 380                 


Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Gln Pro Ser Gln Arg Leu 
385                 390                 395                 400 


Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Tyr Gly Val 
                405                 410                 415     


His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val 
            420                 425                 430         


Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg 
        435                 440                 445             


Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe Lys Met 
    450                 455                 460                 


Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Phe Cys Ala Lys Thr 
465                 470                 475                 480 


Leu Ile Thr Thr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
                485                 490                 495     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ser Ser Phe Ser 
        515                 520                 525             


Val Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp 
    530                 535                 540                 


Ile Tyr Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro 
545                 550                 555                 560 


Arg Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser 
                565                 570                 575     


Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr 
            580                 585                 590         


Ser Leu Gln Thr Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp 
        595                 600                 605             


Ser Thr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
    610                 615                 620             


<210>  17
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  17

Met Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
1               5                   10                  15      


Gly Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            20                  25                  30          


Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
        35                  40                  45              


Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Gly Gly Ser Ser Arg Ser Ser Leu Glu Val 
        115                 120                 125             


Lys Leu Val Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Ser Met 
145                 150                 155                 160 


His Trp Val Asn Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp 
                165                 170                 175     


Ile Asn Thr Glu Thr Gly Glu Pro Ser Tyr Ala Asp Asp Phe Lys Gly 
            180                 185                 190         


Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln 
        195                 200                 205             


Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Thr 
    210                 215                 220                 


Asp Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  18
<211>  132
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  18

Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
1               5                   10                  15      


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        35                  40                  45              


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
65                  70                  75                  80  


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
        115                 120                 125             


Ser Thr Leu Thr 
    130         


<210>  19
<211>  630
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  19

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
                245                 250                 255     


Asn His Ala Tyr Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        275                 280                 285             


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    290                 295                 300                 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
305                 310                 315                 320 


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser 
                325                 330                 335     


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            340                 345                 350         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        355                 360                 365             


Met Phe Ile Asn Thr Ser Glu Ala Ser Gly Gly Pro Glu Met Gly Trp 
    370                 375                 380                 


Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly Val His Ser 
385                 390                 395                 400 


Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
                405                 410                 415     


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            420                 425                 430         


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        435                 440                 445             


Gly Trp Met Lys Pro Arg His Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    450                 455                 460                 


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Ser Glu Thr Ala Phe 
465                 470                 475                 480 


Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                485                 490                 495     


Thr Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Asp Phe 
            500                 505                 510         


Glu His Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr 
        515                 520                 525             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    530                 535                 540                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
545                 550                 555                 560 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                565                 570                 575     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            580                 585                 590         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        595                 600                 605             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    610                 615                 620                 


Pro Lys Ser Cys Asp Lys 
625                 630 


<210>  20
<211>  140
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide

<400>  20

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser 
        35                  40                  45              


Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Ala Val Ala Ser Ile Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Asn Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140 


