                         SEQUENCE LISTING

<110>  Epizyme, Inc.
       THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
 
<120>  METHOD OF TREATING MEDULLOBLASTOMA WITH AN EZH2 INHIBITOR

<130>  EPIZ-053/001WO

<140>  PCT/US2016/055554
<141>  2016-10-05

<150>  62/238,074
<151>  2015-10-06

<150>  62/299,312
<151>  2016-02-24

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Gly Lys Lys Thr Lys Pro Asn Thr Lys Asp His Gly 
65                  70                  75                  80  


Tyr Thr Thr Leu Ala Thr Ser Val Thr Leu Leu Lys Ala Ser Glu Val 
                85                  90                  95      


Glu Glu Ile Leu Asp Gly Asn Asp Glu Lys Tyr Lys Ala Val Ser Ile 
            100                 105                 110         


Ser Thr Glu Pro Pro Thr Tyr Leu Arg Glu Gln Lys Ala Lys Arg Asn 
        115                 120                 125             


Ser Gln Trp Val Pro Thr Leu Pro Asn Ser Ser His His Leu Asp Ala 
    130                 135                 140                 


Val Pro Cys Ser Thr Thr Ile Asn Arg Asn Arg Met Gly Arg Asp Lys 
145                 150                 155                 160 


Lys Arg Thr Phe Pro Leu Cys Phe Asp Asp His Asp Pro Ala Val Ile 
                165                 170                 175     


His Glu Asn Ala Ser Gln Pro Glu Val Leu Val Pro Ile Arg Leu Asp 
            180                 185                 190         


Met Glu Ile Asp Gly Gln Lys Leu Arg Asp Ala Phe Thr Trp Asn Met 
        195                 200                 205             


Asn Glu Lys Leu Met Thr Pro Glu Met Phe Ser Glu Ile Leu Cys Asp 
    210                 215                 220                 


Asp Leu Asp Leu Asn Pro Leu Thr Phe Val Pro Ala Ile Ala Ser Ala 
225                 230                 235                 240 


Ile Arg Gln Gln Ile Glu Ser Tyr Pro Thr Asp Ser Ile Leu Glu Asp 
                245                 250                 255     


Gln Ser Asp Gln Arg Val Ile Ile Lys Leu Asn Ile His Val Gly Asn 
            260                 265                 270         


Ile Ser Leu Val Asp Gln Phe Glu Trp Asp Met Ser Glu Lys Glu Asn 
        275                 280                 285             


Ser Pro Glu Lys Phe Ala Leu Lys Leu Cys Ser Glu Leu Gly Leu Gly 
    290                 295                 300                 


Gly Glu Phe Val Thr Thr Ile Ala Tyr Ser Ile Arg Gly Gln Leu Ser 
305                 310                 315                 320 


Trp His Gln Lys Thr Tyr Ala Phe Ser Glu Asn Pro Leu Pro Thr Val 
                325                 330                 335     


Glu Ile Ala Ile Arg Asn Thr Gly Asp Ala Asp Gln Trp Cys Pro Leu 
            340                 345                 350         


Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg Asp Gln 
        355                 360                 365             


Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala Pro Ala 
    370                 375                 380                 


Trp 
385 


<210>  2
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  2
aacgccagcg cctgcgcact gagggcggcc tggtcgtcgt ctgcggcggc ggcggcggct       60

gaggagcccg gctgaggcgc cagtacccgg cccggtccgc atttcgcctt ccggcttcgg      120

tttccctcgg cccagcacgc cccggccccg ccccagccct cctgatccct cgcagcccgg      180

ctccggccgc ccgcctctgc cgccgcaatg atgatgatgg cgctgagcaa gaccttcggg      240

cagaagcccg tgaagttcca gctggaggac gacggcgagt tctacatgat cggctccgag      300

gtgggaaact acctccgtat gttccgaggt tctctgtaca agagataccc ctcactctgg      360

aggcgactag ccactgtgga agagaggaag aaaatagttg catcgtcaca tggtaaaaaa      420

acaaaaccta acactaagga tcacggatac acgactctag ccaccagtgt gaccctgtta      480

aaagcctcgg aagtggaaga gattctggat ggcaacgatg agaagtacaa ggctgtgtcc      540

atcagcacag agccccccac ctacctcagg gaacagaagg ccaagaggaa cagccagtgg      600

gtacccaccc tgcccaacag ctcccaccac ttagatgccg tgccatgctc cacaaccatc      660

aacaggaacc gcatgggccg agacaagaag agaaccttcc ccctttgctt tgatgaccat      720

gacccagctg tgatccatga gaacgcatct cagcccgagg tgctggtccc catccggctg      780

gacatggaga tcgatgggca gaagctgcga gacgccttca cctggaacat gaatgagaag      840

ttgatgacgc ctgagatgtt ttcagaaatc ctctgtgacg atctggattt gaacccgctg      900

acgtttgtgc cagccatcgc ctctgccatc agacagcaga tcgagtccta ccccacggac      960

agcatcctgg aggaccagtc agaccagcgc gtcatcatca agctgaacat ccatgtggga     1020

aacatttccc tggtggacca gtttgagtgg gacatgtcag agaaggagaa ctcaccagag     1080

aagtttgccc tgaagctgtg ctcggagctg gggttgggcg gggagtttgt caccaccatc     1140

gcatacagca tccggggaca gctgagctgg catcagaaga cctacgcctt cagcgagaac     1200

cctctgccca cagtggagat tgccatccgg aacacgggcg atgcggacca gtggtgccca     1260

ctgctggaga ctctgacaga cgctgagatg gagaagaaga tccgcgacca ggacaggaac     1320

acgaggcgga tgaggcgtct tgccaacacg gccccggcct ggtaaccagc ccatcagcac     1380

acggctccca cggagcatct cagaagattg ggccgcctct cctccatctt ctggcaagga     1440

cagaggcgag gggacagccc agcgccatcc tgaggatcgg gtgggggtgg agtgggggct     1500

tccaggtggc ccttcccggc acacattcca tttgttgagc cccagtcctg ccccccaccc     1560

caccctccct acccctcccc agtctctggg gtcaggaaga aaccttattt taggttgtgt     1620

tttgtttttg tataggagcc ccaggcaggg ctagtaacag tttttaaata aaaggcaaca     1680

ggtcatgttc aatttcttca acaaaaaaaa aaaaaaa                              1717


<210>  3
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Asp His Gly Tyr Thr Thr Leu Ala Thr Ser Val Thr 
65                  70                  75                  80  


Leu Leu Lys Ala Ser Glu Val Glu Glu Ile Leu Asp Gly Asn Asp Glu 
                85                  90                  95      


Lys Tyr Lys Ala Val Ser Ile Ser Thr Glu Pro Pro Thr Tyr Leu Arg 
            100                 105                 110         


Glu Gln Lys Ala Lys Arg Asn Ser Gln Trp Val Pro Thr Leu Pro Asn 
        115                 120                 125             


Ser Ser His His Leu Asp Ala Val Pro Cys Ser Thr Thr Ile Asn Arg 
    130                 135                 140                 


Asn Arg Met Gly Arg Asp Lys Lys Arg Thr Phe Pro Leu Cys Phe Asp 
145                 150                 155                 160 


Asp His Asp Pro Ala Val Ile His Glu Asn Ala Ser Gln Pro Glu Val 
                165                 170                 175     


Leu Val Pro Ile Arg Leu Asp Met Glu Ile Asp Gly Gln Lys Leu Arg 
            180                 185                 190         


Asp Ala Phe Thr Trp Asn Met Asn Glu Lys Leu Met Thr Pro Glu Met 
        195                 200                 205             


Phe Ser Glu Ile Leu Cys Asp Asp Leu Asp Leu Asn Pro Leu Thr Phe 
    210                 215                 220                 


Val Pro Ala Ile Ala Ser Ala Ile Arg Gln Gln Ile Glu Ser Tyr Pro 
225                 230                 235                 240 


Thr Asp Ser Ile Leu Glu Asp Gln Ser Asp Gln Arg Val Ile Ile Lys 
                245                 250                 255     


Leu Asn Ile His Val Gly Asn Ile Ser Leu Val Asp Gln Phe Glu Trp 
            260                 265                 270         


Asp Met Ser Glu Lys Glu Asn Ser Pro Glu Lys Phe Ala Leu Lys Leu 
        275                 280                 285             


Cys Ser Glu Leu Gly Leu Gly Gly Glu Phe Val Thr Thr Ile Ala Tyr 
    290                 295                 300                 


Ser Ile Arg Gly Gln Leu Ser Trp His Gln Lys Thr Tyr Ala Phe Ser 
305                 310                 315                 320 


Glu Asn Pro Leu Pro Thr Val Glu Ile Ala Ile Arg Asn Thr Gly Asp 
                325                 330                 335     


Ala Asp Gln Trp Cys Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met 
            340                 345                 350         


Glu Lys Lys Ile Arg Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg 
        355                 360                 365             


Leu Ala Asn Thr Ala Pro Ala Trp 
    370                 375     


<210>  4
<211>  1690
<212>  DNA
<213>  Homo sapiens

<400>  4
aacgccagcg cctgcgcact gagggcggcc tggtcgtcgt ctgcggcggc ggcggcggct       60

gaggagcccg gctgaggcgc cagtacccgg cccggtccgc atttcgcctt ccggcttcgg      120

tttccctcgg cccagcacgc cccggccccg ccccagccct cctgatccct cgcagcccgg      180

ctccggccgc ccgcctctgc cgccgcaatg atgatgatgg cgctgagcaa gaccttcggg      240

cagaagcccg tgaagttcca gctggaggac gacggcgagt tctacatgat cggctccgag      300

gtgggaaact acctccgtat gttccgaggt tctctgtaca agagataccc ctcactctgg      360

aggcgactag ccactgtgga agagaggaag aaaatagttg catcgtcaca tgatcacgga      420

tacacgactc tagccaccag tgtgaccctg ttaaaagcct cggaagtgga agagattctg      480

gatggcaacg atgagaagta caaggctgtg tccatcagca cagagccccc cacctacctc      540

agggaacaga aggccaagag gaacagccag tgggtaccca ccctgcccaa cagctcccac      600

cacttagatg ccgtgccatg ctccacaacc atcaacagga accgcatggg ccgagacaag      660

aagagaacct tccccctttg ctttgatgac catgacccag ctgtgatcca tgagaacgca      720

tctcagcccg aggtgctggt ccccatccgg ctggacatgg agatcgatgg gcagaagctg      780

cgagacgcct tcacctggaa catgaatgag aagttgatga cgcctgagat gttttcagaa      840

atcctctgtg acgatctgga tttgaacccg ctgacgtttg tgccagccat cgcctctgcc      900

atcagacagc agatcgagtc ctaccccacg gacagcatcc tggaggacca gtcagaccag      960

cgcgtcatca tcaagctgaa catccatgtg ggaaacattt ccctggtgga ccagtttgag     1020

tgggacatgt cagagaagga gaactcacca gagaagtttg ccctgaagct gtgctcggag     1080

ctggggttgg gcggggagtt tgtcaccacc atcgcataca gcatccgggg acagctgagc     1140

tggcatcaga agacctacgc cttcagcgag aaccctctgc ccacagtgga gattgccatc     1200

cggaacacgg gcgatgcgga ccagtggtgc ccactgctgg agactctgac agacgctgag     1260

atggagaaga agatccgcga ccaggacagg aacacgaggc ggatgaggcg tcttgccaac     1320

acggccccgg cctggtaacc agcccatcag cacacggctc ccacggagca tctcagaaga     1380

ttgggccgcc tctcctccat cttctggcaa ggacagaggc gaggggacag cccagcgcca     1440

tcctgaggat cgggtggggg tggagtgggg gcttccaggt ggcccttccc ggcacacatt     1500

ccatttgttg agccccagtc ctgcccccca ccccaccctc cctacccctc cccagtctct     1560

ggggtcagga agaaacctta ttttaggttg tgttttgttt ttgtatagga gccccaggca     1620

gggctagtaa cagtttttaa ataaaaggca acaggtcatg ttcaatttct tcaacaaaaa     1680

aaaaaaaaaa                                                            1690


<210>  5
<211>  2492
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Thr Leu Val Gln 
1               5                   10                  15      


Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Thr 
            20                  25                  30          


Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Thr Asp Lys Ile Ser 
        35                  40                  45              


Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly 
    50                  55                  60                  


Thr Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Lys Pro Ser Ile Val Thr Lys Tyr Val Glu Ser Asp Asp Glu Lys 
                85                  90                  95      


Pro Leu Asp Asp Glu Thr Val Asn Glu Asp Ala Ser Asn Glu Asn Ser 
            100                 105                 110         


Glu Asn Asp Ile Thr Met Gln Ser Leu Pro Lys Gly Thr Val Ile Val 
        115                 120                 125             


Gln Pro Glu Pro Val Leu Asn Glu Asp Lys Asp Asp Phe Lys Gly Pro 
    130                 135                 140                 


Glu Phe Arg Ser Arg Ser Lys Met Lys Thr Glu Asn Leu Lys Lys Arg 
145                 150                 155                 160 


Gly Glu Asp Gly Leu His Gly Ile Val Ser Cys Thr Ala Cys Gly Gln 
                165                 170                 175     


Gln Val Asn His Phe Gln Lys Asp Ser Ile Tyr Arg His Pro Ser Leu 
            180                 185                 190         


Gln Val Leu Ile Cys Lys Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp 
        195                 200                 205             


Ile Ser Arg Asp Ser Asp Gly Met Asp Glu Gln Cys Arg Trp Cys Ala 
    210                 215                 220                 


Glu Gly Gly Asn Leu Ile Cys Cys Asp Phe Cys His Asn Ala Phe Cys 
225                 230                 235                 240 


Lys Lys Cys Ile Leu Arg Asn Leu Gly Arg Lys Glu Leu Ser Thr Ile 
                245                 250                 255     


Met Asp Glu Asn Asn Gln Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro 
            260                 265                 270         


Leu Leu Asp Leu Val Thr Ala Cys Asn Ser Val Phe Glu Asn Leu Glu 
        275                 280                 285             


Gln Leu Leu Gln Gln Asn Lys Lys Lys Ile Lys Val Asp Ser Glu Lys 
    290                 295                 300                 


Ser Asn Lys Val Tyr Glu His Thr Ser Arg Phe Ser Pro Lys Lys Thr 
305                 310                 315                 320 


Ser Ser Asn Cys Asn Gly Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser 
                325                 330                 335     


Gly Ser Val Thr Tyr Ser Tyr Ser Ala Leu Ile Val Pro Lys Glu Met 
            340                 345                 350         


Ile Lys Lys Ala Lys Lys Leu Ile Glu Thr Thr Ala Asn Met Asn Ser 
        355                 360                 365             


Ser Tyr Val Lys Phe Leu Lys Gln Ala Thr Asp Asn Ser Glu Ile Ser 
    370                 375                 380                 


Ser Ala Thr Lys Leu Arg Gln Leu Lys Ala Phe Lys Ser Val Leu Ala 
385                 390                 395                 400 


Asp Ile Lys Lys Ala His Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu 
                405                 410                 415     


Phe Arg Ala Met Asp Ala Val Asn Lys Glu Lys Asn Thr Lys Glu His 
            420                 425                 430         


Lys Val Ile Asp Ala Lys Phe Glu Thr Lys Ala Arg Lys Gly Glu Lys 
        435                 440                 445             


Pro Cys Ala Leu Glu Lys Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu 
    450                 455                 460                 


Ser Arg Lys Gln Val Asp Ser Glu His Met His Gln Asn Val Pro Thr 
465                 470                 475                 480 


Glu Glu Gln Arg Thr Asn Lys Ser Thr Gly Gly Glu His Lys Lys Ser 
                485                 490                 495     


Asp Arg Lys Glu Glu Pro Gln Tyr Glu Pro Ala Asn Thr Ser Glu Asp 
            500                 505                 510         


Leu Asp Met Asp Ile Val Ser Val Pro Ser Ser Val Pro Glu Asp Ile 
        515                 520                 525             


Phe Glu Asn Leu Glu Thr Ala Met Glu Val Gln Ser Ser Val Asp His 
    530                 535                 540                 


Gln Gly Asp Gly Ser Ser Gly Thr Glu Gln Glu Val Glu Ser Ser Ser 
545                 550                 555                 560 


Val Lys Leu Asn Ile Ser Ser Lys Asp Asn Arg Gly Gly Ile Lys Ser 
                565                 570                 575     


Lys Thr Thr Ala Lys Val Thr Lys Glu Leu Tyr Val Lys Leu Thr Pro 
            580                 585                 590         


Val Ser Leu Ser Asn Ser Pro Ile Lys Gly Ala Asp Cys Gln Glu Val 
        595                 600                 605             


Pro Gln Asp Lys Asp Gly Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu 
    610                 615                 620                 


Glu Lys Cys Gly Leu Gly Gln Glu Asn Ser Asp Asn Glu His Leu Val 
625                 630                 635                 640 


Glu Asn Glu Val Ser Leu Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser 
                645                 650                 655     


Pro Arg Val Lys Thr Thr Pro Leu Arg Arg Pro Thr Glu Thr Asn Pro 
            660                 665                 670         


Val Thr Ser Asn Ser Asp Glu Glu Cys Asn Glu Thr Val Lys Glu Lys 
        675                 680                 685             


Gln Lys Leu Ser Val Pro Val Arg Lys Lys Asp Lys Arg Asn Ser Ser 
    690                 695                 700                 


Asp Ser Ala Ile Asp Asn Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys 
705                 710                 715                 720 


Gln Ser Glu Thr Val Asp Gln Asn Ser Asp Ser Asp Glu Met Leu Ala 
                725                 730                 735     


Ile Leu Lys Glu Val Ser Arg Met Ser His Ser Ser Ser Ser Asp Thr 
            740                 745                 750         


Asp Ile Asn Glu Ile His Thr Asn His Lys Thr Leu Tyr Asp Leu Lys 
        755                 760                 765             


Thr Gln Ala Gly Lys Asp Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser 
    770                 775                 780                 


Thr Ser Gly Ser Asp Phe Asp Thr Lys Lys Gly Lys Ser Ala Lys Ser 
785                 790                 795                 800 


Ser Ile Ile Ser Lys Lys Lys Arg Gln Thr Gln Ser Glu Ser Ser Asn 
                805                 810                 815     


Tyr Asp Ser Glu Leu Glu Lys Glu Ile Lys Ser Met Ser Lys Ile Gly 
            820                 825                 830         


Ala Ala Arg Thr Thr Lys Lys Arg Ile Pro Asn Thr Lys Asp Phe Asp 
        835                 840                 845             


Ser Ser Glu Asp Glu Lys His Ser Lys Lys Gly Met Asp Asn Gln Gly 
    850                 855                 860                 


His Lys Asn Leu Lys Thr Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu 
865                 870                 875                 880 


Arg Lys Gln Glu Arg Glu Thr Phe Ser Ser Ala Glu Gly Thr Val Asp 
                885                 890                 895     


Lys Asp Thr Thr Ile Met Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln 
            900                 905                 910         


Gln Ala Ser Ala Ser Thr Asp Gly Val Asp Lys Leu Ser Gly Lys Glu 
        915                 920                 925             


Gln Ser Phe Thr Ser Leu Glu Val Arg Lys Val Ala Glu Thr Lys Glu 
    930                 935                 940                 


Lys Ser Lys His Leu Lys Thr Lys Thr Cys Lys Lys Val Gln Asp Gly 
945                 950                 955                 960 


Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu 
                965                 970                 975     


Thr Ser Glu Asp Asp Lys Lys Gln Ser Lys Lys Gly Thr Glu Glu Lys 
            980                 985                 990         


Lys Lys Pro Ser Asp Phe Lys Lys  Lys Val Ile Lys Met  Glu Gln Gln 
        995                 1000                 1005             


Tyr Glu  Ser Ser Ser Asp Gly  Thr Glu Lys Leu Pro  Glu Arg Glu 
    1010                 1015                 1020             


Glu Ile  Cys His Phe Pro Lys  Gly Ile Lys Gln Ile  Lys Asn Gly 
    1025                 1030                 1035             


Thr Thr  Asp Gly Glu Lys Lys  Ser Lys Lys Ile Arg  Asp Lys Thr 
    1040                 1045                 1050             


Ser Lys  Lys Lys Asp Glu Leu  Ser Asp Tyr Ala Glu  Lys Ser Thr 
    1055                 1060                 1065             


Gly Lys  Gly Asp Ser Cys Asp  Ser Ser Glu Asp Lys  Lys Ser Lys 
    1070                 1075                 1080             


Asn Gly  Ala Tyr Gly Arg Glu  Lys Lys Arg Cys Lys  Leu Leu Gly 
    1085                 1090                 1095             


Lys Ser  Ser Arg Lys Arg Gln  Asp Cys Ser Ser Ser  Asp Thr Glu 
    1100                 1105                 1110             


Lys Tyr  Ser Met Lys Glu Asp  Gly Cys Asn Ser Ser  Asp Lys Arg 
    1115                 1120                 1125             


Leu Lys  Arg Ile Glu Leu Arg  Glu Arg Arg Asn Leu  Ser Ser Lys 
    1130                 1135                 1140             


Arg Asn  Thr Lys Glu Ile Gln  Ser Gly Ser Ser Ser  Ser Asp Ala 
    1145                 1150                 1155             


Glu Glu  Ser Ser Glu Asp Asn  Lys Lys Lys Lys Gln  Arg Thr Ser 
    1160                 1165                 1170             


Ser Lys  Lys Lys Ala Val Ile  Val Lys Glu Lys Lys  Arg Asn Ser 
    1175                 1180                 1185             


Leu Arg  Thr Ser Thr Lys Arg  Lys Gln Ala Asp Ile  Thr Ser Ser 
    1190                 1195                 1200             


Ser Ser  Ser Asp Ile Glu Asp  Asp Asp Gln Asn Ser  Ile Gly Glu 
    1205                 1210                 1215             


Gly Ser  Ser Asp Glu Gln Lys  Ile Lys Pro Val Thr  Glu Asn Leu 
    1220                 1225                 1230             


Val Leu  Ser Ser His Thr Gly  Phe Cys Gln Ser Ser  Gly Asp Glu 
    1235                 1240                 1245             


Ala Leu  Ser Lys Ser Val Pro  Val Thr Val Asp Asp  Asp Asp Asp 
    1250                 1255                 1260             


Asp Asn  Asp Pro Glu Asn Arg  Ile Ala Lys Lys Met  Leu Leu Glu 
    1265                 1270                 1275             


Glu Ile  Lys Ala Asn Leu Ser  Ser Asp Glu Asp Gly  Ser Ser Asp 
    1280                 1285                 1290             


Asp Glu  Pro Glu Glu Gly Lys  Lys Arg Thr Gly Lys  Gln Asn Glu 
    1295                 1300                 1305             


Glu Asn  Pro Gly Asp Glu Glu  Ala Lys Asn Gln Val  Asn Ser Glu 
    1310                 1315                 1320             


Ser Asp  Ser Asp Ser Glu Glu  Ser Lys Lys Pro Arg  Tyr Arg His 
    1325                 1330                 1335             


Arg Leu  Leu Arg His Lys Leu  Thr Val Ser Asp Gly  Glu Ser Gly 
    1340                 1345                 1350             


Glu Glu  Lys Lys Thr Lys Pro  Lys Glu His Lys Glu  Val Lys Gly 
    1355                 1360                 1365             


Arg Asn  Arg Arg Lys Val Ser  Ser Glu Asp Ser Glu  Asp Ser Asp 
    1370                 1375                 1380             


Phe Gln  Glu Ser Gly Val Ser  Glu Glu Val Ser Glu  Ser Glu Asp 
    1385                 1390                 1395             


Glu Gln  Arg Pro Arg Thr Arg  Ser Ala Lys Lys Ala  Glu Leu Glu 
    1400                 1405                 1410             


Glu Asn  Gln Arg Ser Tyr Lys  Gln Lys Lys Lys Arg  Arg Arg Ile 
    1415                 1420                 1425             


Lys Val  Gln Glu Asp Ser Ser  Ser Glu Asn Lys Ser  Asn Ser Glu 
    1430                 1435                 1440             


Glu Glu  Glu Glu Glu Lys Glu  Glu Glu Glu Glu Glu  Glu Glu Glu 
    1445                 1450                 1455             


Glu Glu  Glu Glu Glu Glu Asp  Glu Asn Asp Asp Ser  Lys Ser Pro 
    1460                 1465                 1470             


Gly Lys  Gly Arg Lys Lys Ile  Arg Lys Ile Leu Lys  Asp Asp Lys 
    1475                 1480                 1485             


Leu Arg  Thr Glu Thr Gln Asn  Ala Leu Lys Glu Glu  Glu Glu Arg 
    1490                 1495                 1500             


Arg Lys  Arg Ile Ala Glu Arg  Glu Arg Glu Arg Glu  Lys Leu Arg 
    1505                 1510                 1515             


Glu Val  Ile Glu Ile Glu Asp  Ala Ser Pro Thr Lys  Cys Pro Ile 
    1520                 1525                 1530             


Thr Thr  Lys Leu Val Leu Asp  Glu Asp Glu Glu Thr  Lys Glu Pro 
    1535                 1540                 1545             


Leu Val  Gln Val His Arg Asn  Met Val Ile Lys Leu  Lys Pro His 
    1550                 1555                 1560             


Gln Val  Asp Gly Val Gln Phe  Met Trp Asp Cys Cys  Cys Glu Ser 
    1565                 1570                 1575             


Val Lys  Lys Thr Lys Lys Ser  Pro Gly Ser Gly Cys  Ile Leu Ala 
    1580                 1585                 1590             


His Cys  Met Gly Leu Gly Lys  Thr Leu Gln Val Val  Ser Phe Leu 
    1595                 1600                 1605             


His Thr  Val Leu Leu Cys Asp  Lys Leu Asp Phe Ser  Thr Ala Leu 
    1610                 1615                 1620             


Val Val  Cys Pro Leu Asn Thr  Ala Leu Asn Trp Met  Asn Glu Phe 
    1625                 1630                 1635             


Glu Lys  Trp Gln Glu Gly Leu  Lys Asp Asp Glu Lys  Leu Glu Val 
    1640                 1645                 1650             


Ser Glu  Leu Ala Thr Val Lys  Arg Pro Gln Glu Arg  Ser Tyr Met 
    1655                 1660                 1665             


Leu Gln  Arg Trp Gln Glu Asp  Gly Gly Val Met Ile  Ile Gly Tyr 
    1670                 1675                 1680             


Glu Met  Tyr Arg Asn Leu Ala  Gln Gly Arg Asn Val  Lys Ser Arg 
    1685                 1690                 1695             


Lys Leu  Lys Glu Ile Phe Asn  Lys Ala Leu Val Asp  Pro Gly Pro 
    1700                 1705                 1710             


Asp Phe  Val Val Cys Asp Glu  Gly His Ile Leu Lys  Asn Glu Ala 
    1715                 1720                 1725             


Ser Ala  Val Ser Lys Ala Met  Asn Ser Ile Arg Ser  Arg Arg Arg 
    1730                 1735                 1740             


Ile Ile  Leu Thr Gly Thr Pro  Leu Gln Asn Asn Leu  Ile Glu Tyr 
    1745                 1750                 1755             


His Cys  Met Val Asn Phe Ile  Lys Glu Asn Leu Leu  Gly Ser Ile 
    1760                 1765                 1770             


Lys Glu  Phe Arg Asn Arg Phe  Ile Asn Pro Ile Gln  Asn Gly Gln 
    1775                 1780                 1785             


Cys Ala  Asp Ser Thr Met Val  Asp Val Arg Val Met  Lys Lys Arg 
    1790                 1795                 1800             


Ala His  Ile Leu Tyr Glu Met  Leu Ala Gly Cys Val  Gln Arg Lys 
    1805                 1810                 1815             


Asp Tyr  Thr Ala Leu Thr Lys  Phe Leu Pro Pro Lys  His Glu Tyr 
    1820                 1825                 1830             


Val Leu  Ala Val Arg Met Thr  Ser Ile Gln Cys Lys  Leu Tyr Gln 
    1835                 1840                 1845             


Tyr Tyr  Leu Asp His Leu Thr  Gly Val Gly Asn Asn  Ser Glu Gly 
    1850                 1855                 1860             


Gly Arg  Gly Lys Ala Gly Ala  Lys Leu Phe Gln Asp  Phe Gln Met 
    1865                 1870                 1875             


Leu Ser  Arg Ile Trp Thr His  Pro Trp Cys Leu Gln  Leu Asp Tyr 
    1880                 1885                 1890             


Ile Ser  Lys Glu Asn Lys Gly  Tyr Phe Asp Glu Asp  Ser Met Asp 
    1895                 1900                 1905             


Glu Phe  Ile Ala Ser Asp Ser  Asp Glu Thr Ser Met  Ser Leu Ser 
    1910                 1915                 1920             


Ser Asp  Asp Tyr Thr Lys Lys  Lys Lys Lys Gly Lys  Lys Gly Lys 
    1925                 1930                 1935             


Lys Asp  Ser Ser Ser Ser Gly  Ser Gly Ser Asp Asn  Asp Val Glu 
    1940                 1945                 1950             


Val Ile  Lys Val Trp Asn Ser  Arg Ser Arg Gly Gly  Gly Glu Gly 
    1955                 1960                 1965             


Asn Val  Asp Glu Thr Gly Asn  Asn Pro Ser Val Ser  Leu Lys Leu 
    1970                 1975                 1980             


Glu Glu  Ser Lys Ala Thr Ser  Ser Ser Asn Pro Ser  Ser Pro Ala 
    1985                 1990                 1995             


Pro Asp  Trp Tyr Lys Asp Phe  Val Thr Asp Ala Asp  Ala Glu Val 
    2000                 2005                 2010             


Leu Glu  His Ser Gly Lys Met  Val Leu Leu Phe Glu  Ile Leu Arg 
    2015                 2020                 2025             


Met Ala  Glu Glu Ile Gly Asp  Lys Val Leu Val Phe  Ser Gln Ser 
    2030                 2035                 2040             


Leu Ile  Ser Leu Asp Leu Ile  Glu Asp Phe Leu Glu  Leu Ala Ser 
    2045                 2050                 2055             


Arg Glu  Lys Thr Glu Asp Lys  Asp Lys Pro Leu Ile  Tyr Lys Gly 
    2060                 2065                 2070             


Glu Gly  Lys Trp Leu Arg Asn  Ile Asp Tyr Tyr Arg  Leu Asp Gly 
    2075                 2080                 2085             


Ser Thr  Thr Ala Gln Ser Arg  Lys Lys Trp Ala Glu  Glu Phe Asn 
    2090                 2095                 2100             


Asp Glu  Thr Asn Val Arg Gly  Arg Leu Phe Ile Ile  Ser Thr Lys 
    2105                 2110                 2115             


Ala Gly  Ser Leu Gly Ile Asn  Leu Val Ala Ala Asn  Arg Val Ile 
    2120                 2125                 2130             


Ile Phe  Asp Ala Ser Trp Asn  Pro Ser Tyr Asp Ile  Gln Ser Ile 
    2135                 2140                 2145             


Phe Arg  Val Tyr Arg Phe Gly  Gln Thr Lys Pro Val  Tyr Val Tyr 
    2150                 2155                 2160             


Arg Phe  Leu Ala Gln Gly Thr  Met Glu Asp Lys Ile  Tyr Asp Arg 
    2165                 2170                 2175             


Gln Val  Thr Lys Gln Ser Leu  Ser Phe Arg Val Val  Asp Gln Gln 
    2180                 2185                 2190             


Gln Val  Glu Arg His Phe Thr  Met Asn Glu Leu Thr  Glu Leu Tyr 
    2195                 2200                 2205             


Thr Phe  Glu Pro Asp Leu Leu  Asp Asp Pro Asn Ser  Glu Lys Lys 
    2210                 2215                 2220             


Lys Lys  Arg Asp Thr Pro Met  Leu Pro Lys Asp Thr  Ile Leu Ala 
    2225                 2230                 2235             


Glu Leu  Leu Gln Ile His Lys  Glu His Ile Val Gly  Tyr His Glu 
    2240                 2245                 2250             


His Asp  Ser Leu Leu Asp His  Lys Glu Glu Glu Glu  Leu Thr Glu 
    2255                 2260                 2265             


Glu Glu  Arg Lys Ala Ala Trp  Ala Glu Tyr Glu Ala  Glu Lys Lys 
    2270                 2275                 2280             


Gly Leu  Thr Met Arg Phe Asn  Ile Pro Thr Gly Thr  Asn Leu Pro 
    2285                 2290                 2295             


Pro Val  Ser Phe Asn Ser Gln  Thr Pro Tyr Ile Pro  Phe Asn Leu 
    2300                 2305                 2310             


Gly Ala  Leu Ser Ala Met Ser  Asn Gln Gln Leu Glu  Asp Leu Ile 
    2315                 2320                 2325             


Asn Gln  Gly Arg Glu Lys Val  Val Glu Ala Thr Asn  Ser Val Thr 
    2330                 2335                 2340             


Ala Val  Arg Ile Gln Pro Leu  Glu Asp Ile Ile Ser  Ala Val Trp 
    2345                 2350                 2355             


Lys Glu  Asn Met Asn Leu Ser  Glu Ala Gln Val Gln  Ala Leu Ala 
    2360                 2365                 2370             


Leu Ser  Arg Gln Ala Ser Gln  Glu Leu Asp Val Lys  Arg Arg Glu 
    2375                 2380                 2385             


Ala Ile  Tyr Asn Asp Val Leu  Thr Lys Gln Gln Met  Leu Ile Ser 
    2390                 2395                 2400             


Cys Val  Gln Arg Ile Leu Met  Asn Arg Arg Leu Gln  Gln Gln Tyr 
    2405                 2410                 2415             


Asn Gln  Gln Gln Gln Gln Gln  Met Thr Tyr Gln Gln  Ala Thr Leu 
    2420                 2425                 2430             


Gly His  Leu Met Met Pro Lys  Pro Pro Asn Leu Ile  Met Asn Pro 
    2435                 2440                 2445             


Ser Asn  Tyr Gln Gln Ile Asp  Met Arg Gly Met Tyr  Gln Pro Val 
    2450                 2455                 2460             


Ala Gly  Gly Met Gln Pro Pro  Pro Leu Gln Arg Ala  Pro Pro Pro 
    2465                 2470                 2475             


Met Arg  Ser Lys Asn Pro Gly  Pro Ser Gln Gly Lys  Ser Met 
    2480                 2485                 2490         


<210>  6
<211>  11202
<212>  DNA
<213>  Homo sapiens

<400>  6
aattctcctg cctgagcctc ggcccaacaa aatggcggcg gcagcggtgt cgctttgttt       60

ccgcggctcc tgcggcggtg gcagtggtag cggcctttga gctgtgggga ggttccagca      120

gcagctacag tgacgactaa gactccagtg catttctatc gtaaccgggc gcgggggagc      180

gcagatcggc gcccagcaat cacagaagcc gacaaggcgt tcaagcgaaa acatgaccgc      240

tgagcccatg agtgaaagca agttgaatac attggtgcag aagcttcatg acttccttgc      300

acactcatca gaagaatctg aagaaacaag ttctcctcca cgacttgcaa tgaatcaaaa      360

cacagataaa atcagtggtt ctggaagtaa ctctgatatg atggaaaaca gcaaggaaga      420

gggaactagc tcttcagaaa aatccaagtc ttcaggatcg tcacgatcaa agaggaaacc      480

ttcaattgta acaaagtatg tagaatcaga tgatgaaaaa cctttggatg atgaaactgt      540

aaatgaagat gcgtctaatg aaaattcaga aaatgatatt actatgcaga gcttgccaaa      600

aggtacagtg attgtacagc cagagccagt gctgaatgaa gacaaagatg attttaaagg      660

gcctgaattt agaagcagaa gtaaaatgaa aactgaaaat ctcaaaaaac gcggagaaga      720

tgggcttcat gggattgtga gctgcactgc ttgtggacaa caggtcaatc attttcaaaa      780

agattccatt tatagacacc cttcattgca agttcttatt tgtaagaatt gctttaagta      840

ttacatgagt gatgatatta gccgtgactc agatggaatg gatgaacaat gtaggtggtg      900

tgcggaaggt ggaaacttga tttgttgtga cttttgccat aatgctttct gcaagaaatg      960

cattctacgc aaccttggtc gaaaggagtt gtccacaata atggatgaaa acaaccaatg     1020

gtattgctac atttgtcacc cagagccttt gttggacttg gtcactgcat gtaacagcgt     1080

atttgagaat ttagaacagt tgttgcagca aaataagaag aagataaaag ttgacagtga     1140

aaagagtaat aaagtatatg aacatacatc cagattttct ccaaagaaga ctagttcaaa     1200

ttgtaatgga gaagaaaaga aattagatga ttcctgttct ggctctgtaa cctactctta     1260

ttccgcacta attgtgccca aagagatgat taagaaggca aaaaaactga ttgagaccac     1320

agccaacatg aactccagtt atgttaaatt tttaaagcag gcaacagata attcagaaat     1380

cagttctgct acaaaattac gtcagcttaa ggcttttaag tctgtgttgg ctgatattaa     1440

gaaggctcat cttgcattgg aagaagactt aaattccgag tttcgagcga tggatgctgt     1500

aaacaaagag aaaaatacca aagagcataa agtcatagat gctaagtttg aaacaaaagc     1560

acgaaaagga gaaaaacctt gtgctttgga aaagaaggat atttcaaagt cagaagctaa     1620

actttcaaga aaacaggtag atagtgagca catgcatcag aatgttccaa cagaggaaca     1680

aagaacaaat aaaagtaccg gtggtgaaca taagaaatct gatagaaaag aagaacctca     1740

atatgaacct gccaacactt ctgaagattt agacatggat attgtgtctg ttccttcctc     1800

agttccagaa gacatttttg agaatcttga gactgctatg gaagttcaga gttcagttga     1860

tcatcaaggg gatggcagca gtggaactga acaagaagtg gagagttcat ctgtaaaatt     1920

aaatatttct tcaaaagaca acagaggagg tattaaatca aaaactacag ctaaagtaac     1980

aaaagaatta tatgttaaac tcactcctgt ttccctttct aattccccaa ttaaaggtgc     2040

tgattgtcag gaagttccac aagataaaga tggctataaa agttgtggtc tgaaccccaa     2100

gttagagaaa tgtggacttg gacaggaaaa cagtgataat gagcatttgg ttgaaaatga     2160

agtttcatta cttttagagg aatctgatct tcgaagatcc ccacgtgtaa agactacacc     2220

cttgaggcga ccgacagaaa ctaaccctgt aacatctaat tcagatgaag aatgtaatga     2280

aacagttaag gagaaacaaa aactatcagt tccagtgaga aaaaaggata agcgtaattc     2340

ttctgacagt gctatagata atcctaagcc taataaattg ccaaaatcta agcaatcaga     2400

gactgtggat caaaattcag attctgatga aatgctagca atcctcaaag aggtgagcag     2460

gatgagtcac agttcttctt cagatactga tattaatgaa attcatacaa accataagac     2520

tttgtatgat ttaaagactc aggcggggaa agatgataaa ggaaaaagga aacgaaaaag     2580

ttctacatct ggctcagatt ttgatactaa aaagggcaaa tcagctaaga gctctataat     2640

ttctaaaaag aaacgacaaa cccagtctga gtcttctaat tatgactcag aattagaaaa     2700

agagataaag agcatgagta aaattggtgc tgccagaacc accaaaaaaa gaattccaaa     2760

tacaaaagat tttgactctt ctgaagatga gaaacacagc aaaaaaggaa tggataatca     2820

agggcacaaa aatttgaaga cctcacaaga aggatcatct gatgatgctg aaagaaaaca     2880

agagagagag actttctctt cagcagaagg cacagttgat aaagacacga ccatcatgga     2940

attaagagat cgacttccta agaagcagca agcaagtgct tccactgatg gtgtcgataa     3000

gctttctggg aaagagcaga gttttacttc tttggaagtt agaaaagttg ctgaaactaa     3060

agaaaagagc aagcatctca aaaccaaaac atgtaaaaaa gtacaggatg gcttatctga     3120

tattgcagag aaattcctaa agaaagacca gagcgatgaa acttctgaag atgataaaaa     3180

gcagagcaaa aagggaactg aagaaaaaaa gaaaccttca gactttaaga aaaaagtaat     3240

taaaatggaa caacagtatg aatcttcatc tgatggcact gaaaagttac ctgagcgaga     3300

agaaatttgt cattttccta agggcataaa acaaattaag aatggaacaa ctgatggaga     3360

aaagaaaagt aaaaaaataa gagataaaac ttctaaaaag aaggatgaat tatctgatta     3420

tgctgagaag tcaacaggga aaggagatag ttgtgactct tcagaggata aaaagagtaa     3480

gaatggagca tatggtagag agaagaaaag gtgcaagttg cttggaaaga gttcaaggaa     3540

gagacaagat tgttcatcat ctgatactga gaaatattcc atgaaagaag atggttgtaa     3600

ctcttctgat aagagactga aaagaataga attgagggaa agaagaaatt taagttcaaa     3660

gagaaatact aaggaaatac aaagtggctc atcatcatct gatgctgagg aaagttctga     3720

agataataaa aagaagaagc aaagaacttc atctaaaaag aaggcagtca ttgtcaagga     3780

gaaaaagaga aactccctaa gaacaagcac taaaaggaag caagctgaca ttacatcctc     3840

atcttcttct gatatagaag atgatgatca gaattctata ggtgagggaa gcagcgatga     3900

acagaaaatt aagcctgtga ctgaaaattt agtgctgtct tcacatactg gattttgcca     3960

atcttcagga gatgaagcct tatctaaatc agtgcctgtc acagtggatg atgatgatga     4020

cgacaatgat cctgagaata gaattgccaa gaagatgctt ttagaagaaa ttaaagccaa     4080

tctttcctct gatgaggatg gatcttcaga tgatgagcca gaagaaggga aaaaaagaac     4140

tggaaaacaa aatgaagaaa acccaggaga tgaggaagca aaaaatcaag tcaattctga     4200

atcagattca gattctgaag aatctaagaa gccaagatac agacataggc ttttgcggca     4260

caaattgact gtgagtgacg gagaatctgg agaagaaaaa aagacaaagc ctaaagagca     4320

taaagaagtc aaaggcagaa acagaagaaa ggtgagcagt gaagattcag aagattctga     4380

ttttcaggaa tcaggagtta gtgaagaagt tagtgaatcc gaagatgaac agcggcccag     4440

aacaaggtct gcaaagaaag cagagttgga agaaaatcag cggagctata aacagaaaaa     4500

gaaaaggcga cgtattaagg ttcaagaaga ttcatccagt gaaaacaaga gtaattctga     4560

ggaagaagag gaggaaaaag aagaggagga ggaagaggag gaggaggagg aagaggagga     4620

ggaagatgaa aatgatgatt ccaagtctcc tggaaaaggc agaaagaaaa ttcggaagat     4680

tcttaaagat gataaactga gaacagaaac acaaaatgct cttaaggaag aggaagagag     4740

acgaaaacgt attgctgaga gggagcgtga gcgagaaaaa ttgagagagg tgatagaaat     4800

tgaagatgct tcacccacca agtgtccaat aacaaccaag ttggttttag atgaagatga     4860

agaaaccaaa gaacctttag tgcaggttca tagaaatatg gttatcaaat tgaaacccca     4920

tcaagtagat ggtgttcagt ttatgtggga ttgctgctgt gagtctgtga aaaaaacaaa     4980

gaaatctcca ggttcaggat gcattcttgc ccactgtatg ggccttggta agactttaca     5040

ggtggtaagt tttcttcata cagttctttt gtgtgacaaa ctggatttca gcacggcgtt     5100

agtggtttgt cctcttaata ctgctttgaa ttggatgaat gaatttgaga agtggcaaga     5160

gggattaaaa gatgatgaga agcttgaggt ttctgaatta gcaactgtga aacgtcctca     5220

ggagagaagc tacatgctgc agaggtggca agaagatggt ggtgttatga tcataggcta     5280

tgagatgtat agaaatcttg ctcaaggaag gaatgtgaag agtcggaaac ttaaagaaat     5340

atttaacaaa gctttggttg atccaggccc tgattttgtt gtttgtgatg aaggccatat     5400

tctaaaaaat gaagcatctg ctgtttctaa agctatgaat tctatacgat caaggaggag     5460

gattatttta acaggaacac cacttcaaaa taacctaatt gagtatcatt gtatggttaa     5520

ttttatcaag gaaaatttac ttggatccat taaggagttc aggaatagat ttataaatcc     5580

aattcaaaat ggtcagtgtg cagattctac catggtagat gtcagagtga tgaaaaaacg     5640

tgctcacatt ctctatgaga tgttagctgg atgtgttcag aggaaagatt atacagcatt     5700

aacaaaattc ttgcctccaa aacacgaata tgtgttagct gtgagaatga cttctattca     5760

gtgcaagctc tatcagtact acttagatca cttaacaggt gtgggcaata atagtgaagg     5820

tggaagagga aaggcaggtg caaagctttt ccaagatttt cagatgttaa gtagaatatg     5880

gactcatcct tggtgtttgc agctagacta cattagcaaa gaaaataagg gttattttga     5940

tgaagacagt atggatgaat ttatagcctc agattctgat gaaacctcca tgagtttaag     6000

ctccgatgat tatacaaaaa agaagaaaaa agggaaaaag gggaaaaaag atagtagctc     6060

aagtggaagt ggcagtgaca atgatgttga agtgattaag gtctggaatt caagatctcg     6120

gggaggtggt gaaggaaatg tggatgaaac aggaaacaat ccttctgttt ctttaaaact     6180

ggaagaaagt aaagctactt cttcttctaa tccaagcagc ccagctccag actggtacaa     6240

agattttgtt acagatgctg atgctgaggt tttagagcat tctgggaaaa tggtacttct     6300

ctttgaaatt cttcgaatgg cagaggaaat tggggataaa gtccttgttt tcagccagtc     6360

cctcatatct ctggacttga ttgaagattt tcttgaatta gctagtaggg agaagacaga     6420

agataaagat aaacccctta tttataaagg tgaggggaag tggcttcgaa acattgacta     6480

ttaccgttta gatggttcca ctactgcaca gtcaaggaag aagtgggctg aagaatttaa     6540

tgatgaaact aatgtgagag gacgattatt tatcatttct actaaagcag gatctctagg     6600

aattaatctg gtagctgcta atcgagtaat tatattcgac gcttcttgga atccatctta     6660

tgacatccag agtatattca gagtttatcg ctttggacaa actaagcctg tttatgtata     6720

taggttctta gctcagggaa ccatggaaga taagatttat gatcggcaag taactaagca     6780

gtcactgtct tttcgagttg ttgatcagca gcaggtggag cgtcatttta ctatgaatga     6840

gcttactgaa ctttatactt ttgagccaga cttattagat gaccctaatt cagaaaagaa     6900

gaagaagagg gatactccca tgctgccaaa ggataccata cttgcagagc tccttcagat     6960

acataaagaa cacattgtag gataccatga acatgattct cttttggacc acaaagaaga     7020

agaagagttg actgaagaag aaagaaaagc agcttgggct gagtatgaag cagagaagaa     7080

gggactgacc atgcgtttca acataccaac tgggaccaat ttaccccctg tcagtttcaa     7140

ctctcaaact ccttatattc ctttcaattt gggagccctg tcagcaatga gtaatcaaca     7200

gctggaggac ctcattaatc aaggaagaga aaaagttgta gaagcaacaa acagtgtgac     7260

agcagtgagg attcaacctc ttgaggatat aatttcagct gtatggaagg agaacatgaa     7320

tctctcagag gcccaagtac aggcgttagc attaagtaga caagccagcc aggagcttga     7380

tgttaaacga agagaagcaa tctacaatga tgtattgaca aaacaacaga tgttaatcag     7440

ctgtgttcag cgaatactta tgaacagaag gctccagcag cagtacaatc agcagcaaca     7500

gcaacaaatg acttatcaac aagcaacact gggtcacctc atgatgccaa agcccccaaa     7560

tttgatcatg aatccttcta actaccagca gattgatatg agaggaatgt atcagccagt     7620

ggctggtggt atgcagccac caccattaca gcgtgcacca cccccaatga gaagcaaaaa     7680

tccaggacct tcccaaggga aatcaatgtg attttgcact aaaagcttaa tggattgtta     7740

aaatcataga aagatctttt atttttttag gaatcaatga cttaacagaa ctcaactgta     7800

taaatagttt ggtcccctta aatgccaatc ttccatatta gttttacttt tttttttttt     7860

aaatagggca taccatttct tcctgacatt tgtcagtgat gttgcctaga atcttcttac     7920

acacgctgag tacagaagat atttcaaatt gttttcagtg aaaacaagtc cttccataat     7980

agtaacaact ccacagattt cctctctaaa tttttatgcc tgcttttagc aaccataaaa     8040

ttgtcataaa attaataaat ttaggaaaga ataaagattt atatattcat tctttacata     8100

taaaaacaca cagctgagtt cttagagttg attcctcaag ttatgaaata cttttgtact     8160

taatccattt cttgattaaa gtgattgaaa tggttttaat gttcttttga ctgaagtctg     8220

aaactgggct cctgctttat tgtctctgtg actgaaagtt agaaactgag ggttatcttt     8280

gacacagaat tgtgtgcaat attcttaaat actactgctc taaaagttgg agaagtcttg     8340

cagttatctt agcattgtat aaacagcctt aagtatagcc taagaagaga attccttttt     8400

cttctttagt ccttctgcca ttttttattt tcagttatat gtgctgaaat aattactggt     8460

aaaatttcag ggttgtggat tatcttccac acatgaattt tctctctcct ggcacgaata     8520

taaagcacat ctcttaactg catggtgcca gtgctaatgc ttcatcctgt tgctggcagt     8580

gggatgtgga cttagaaaat caagttctag cattttagta ggttaacact gaagttgtgg     8640

ttgttaggtt cacaccctgt tttataaaca acatcaaaat ggcagaacca ttgctgactt     8700

taggttcaca tgaggaatgt acttttaaca attcccagta ctatcagtat tgtgaaataa     8760

ttcctctgaa agataagaat cactggcttc tatgcgcttc ttttctctca tcatcatgtt     8820

cttttacccc agtttcctta cattttttta aattgtttca gagtttgttt tttttttagt     8880

ttagattgtg aggcaattat taaatcaaaa ttaattcatc caatacccct ttactagaag     8940

ttttactaga aaatgtatta cattttattt tttcttaatc cagttctgca aaaatgacct     9000

ataaatttat tcatgtacaa ttttggttac ttgaattgtt aaagaaaaca ttgtttttga     9060

ctatgggagt caactcaaca tggcagaacc atttttgaga tgatgataca acaggtagtg     9120

aaacagctta agaattccaa aaaaaaaaaa aaaaaaaaaa aaaagaaaac tgggtttggg     9180

ctttgcttta ggtatcactg gattagaatg agtttaacat tagctaaaac tgctttgagt     9240

tgtttggatg attaagagat tgccattttt atcttggaag aactagtggt aaaacatcca     9300

agagcactag gattgtgata cagaatttgt gaggtttggt ggatccacgc ccctctcccc     9360

cactttccca tgatgaaata tcactaataa atcctgtata tttagatatt atgctagcca     9420

tgtaatcaga tttatttaat tgggtggggc aggtgtgtat ttactttaga aaaaatgaaa     9480

aagacaagat ttatgagaaa tatttgaagg cagtacactc tggccaactg ttaccagttg     9540

gtatttctac aagttcagaa tattttaaac ctgatttact agacctggga attttcaaca     9600

tggtctaatt atttactcaa agacatagat gtgaaaattt taggcaacct tctaaatctt     9660

tttcaccatg gatgaaacta taacttaaag aataatactt agaagggtta attggaaatc     9720

agagtttgaa ataaaacttg gaccactttg tatacactct tctcacttga cattttagct     9780

atataatatg tactttgagt ataacatcaa gctttaacaa atatttaaag acaaaaaaat     9840

cacgtcagta aaatactaaa aggctcattt ttatatttgt tttagatgtt ttaaatagtt     9900

gcaatggatt aaaaatgatg atttaaaatg ttgcttgtaa tacagttttg cctgctaaat     9960

tctccacatt ttgtaacctg ttttatttct ttgggtgtaa agcgtttttg cttagtattg    10020

tgatattgta tatgttttgt cccagttgta tagtaatgtt tcagtccatc atccagcttt    10080

ggctgctgaa atcatacagc tgtgaagact tgcctttgtt tctgttagac tgcttttcag    10140

ttctgtattg agtatcttaa gtactgtaga aaagatgtca cttcttcctt taaggctgtt    10200

ttgtaatata tataaggact ggaattgtgt ttttaaagaa aagcattcaa gtatgacaat    10260

atactatctg tgttttcacc attcaaagtg ctgtttagta gttgaaactt aaactattta    10320

atgtcattta ataaagtgac caaaatgtgt tgtgctcttt attgtatttt cacagctttg    10380

aaaatctgtg cacatactgt ttcatagaaa atgtatagct tttgttgtcc tatataatgg    10440

tggttctttt gcacatttag ttatttaata ttgagaggtc acgaagtttg gttattgaat    10500

ctgttatata ctaaattctg taaagggaga tctctcatct caaaaagaat ttacatacca    10560

ggaagtccat gtgtgtttgt gttagttttg gatgtctttg tgtaatccag ccccatttcc    10620

tgtttcccaa cagctgtaac actcatttta agtcaagcag ggctaccaac ccacacttga    10680

tagaaaagct gcttaccatt cagaagcttc cttattacct ggcctccaaa tgagctgaat    10740

attttgtagc cttcccttag ctatgttcat tttccctcca ttatcataaa atcagatcga    10800

tatttatgtg ccccaaacaa aactttaaga gcagttacat tctgtcccag tagcccttgt    10860

ttcctttgag agtagcatgt tgtgaggcta tagagactta ttctaccagt aaaacaggtc    10920

aatcctttta catgtttatt atactaaaaa ttatgttcag ggtatttact actttatttc    10980

accagactca gtctcaagtg acttggctat ctccaaatca gatctaccct tagagaataa    11040

acatttttct accgttattt tttttcaagt ctataatctg agccagtccc aaaggagtga    11100

tcaagtttca gaaatgcttt catcttcaca acattttata tatactatta tatggggtga    11160

ataaagtttt aaatccgaaa tataaaaaaa aaaaaaaaaa aa                       11202


<210>  7
<211>  2454
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Thr Leu Val Gln 
1               5                   10                  15      


Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Thr 
            20                  25                  30          


Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Thr Asp Lys Ile Ser 
        35                  40                  45              


Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly 
    50                  55                  60                  


Thr Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Lys Pro Ser Ile Val Thr Lys Tyr Val Glu Ser Asp Asp Glu Lys 
                85                  90                  95      


Pro Leu Asp Asp Glu Thr Val Asn Glu Asp Ala Ser Asn Glu Asn Ser 
            100                 105                 110         


Glu Asn Asp Ile Thr Met Gln Ser Leu Pro Lys Glu Asp Gly Leu His 
        115                 120                 125             


Gly Ile Val Ser Cys Thr Ala Cys Gly Gln Gln Val Asn His Phe Gln 
    130                 135                 140                 


Lys Asp Ser Ile Tyr Arg His Pro Ser Leu Gln Val Leu Ile Cys Lys 
145                 150                 155                 160 


Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp Ile Ser Arg Asp Ser Asp 
                165                 170                 175     


Gly Met Asp Glu Gln Cys Arg Trp Cys Ala Glu Gly Gly Asn Leu Ile 
            180                 185                 190         


Cys Cys Asp Phe Cys His Asn Ala Phe Cys Lys Lys Cys Ile Leu Arg 
        195                 200                 205             


Asn Leu Gly Arg Lys Glu Leu Ser Thr Ile Met Asp Glu Asn Asn Gln 
    210                 215                 220                 


Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro Leu Leu Asp Leu Val Thr 
225                 230                 235                 240 


Ala Cys Asn Ser Val Phe Glu Asn Leu Glu Gln Leu Leu Gln Gln Asn 
                245                 250                 255     


Lys Lys Lys Ile Lys Val Asp Ser Glu Lys Ser Asn Lys Val Tyr Glu 
            260                 265                 270         


His Thr Ser Arg Phe Ser Pro Lys Lys Thr Ser Ser Asn Cys Asn Gly 
        275                 280                 285             


Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser Gly Ser Val Thr Tyr Ser 
    290                 295                 300                 


Tyr Ser Ala Leu Ile Val Pro Lys Glu Met Ile Lys Lys Ala Lys Lys 
305                 310                 315                 320 


Leu Ile Glu Thr Thr Ala Asn Met Asn Ser Ser Tyr Val Lys Phe Leu 
                325                 330                 335     


Lys Gln Ala Thr Asp Asn Ser Glu Ile Ser Ser Ala Thr Lys Leu Arg 
            340                 345                 350         


Gln Leu Lys Ala Phe Lys Ser Val Leu Ala Asp Ile Lys Lys Ala His 
        355                 360                 365             


Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu Phe Arg Ala Met Asp Ala 
    370                 375                 380                 


Val Asn Lys Glu Lys Asn Thr Lys Glu His Lys Val Ile Asp Ala Lys 
385                 390                 395                 400 


Phe Glu Thr Lys Ala Arg Lys Gly Glu Lys Pro Cys Ala Leu Glu Lys 
                405                 410                 415     


Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu Ser Arg Lys Gln Val Asp 
            420                 425                 430         


Ser Glu His Met His Gln Asn Val Pro Thr Glu Glu Gln Arg Thr Asn 
        435                 440                 445             


Lys Ser Thr Gly Gly Glu His Lys Lys Ser Asp Arg Lys Glu Glu Pro 
    450                 455                 460                 


Gln Tyr Glu Pro Ala Asn Thr Ser Glu Asp Leu Asp Met Asp Ile Val 
465                 470                 475                 480 


Ser Val Pro Ser Ser Val Pro Glu Asp Ile Phe Glu Asn Leu Glu Thr 
                485                 490                 495     


Ala Met Glu Val Gln Ser Ser Val Asp His Gln Gly Asp Gly Ser Ser 
            500                 505                 510         


Gly Thr Glu Gln Glu Val Glu Ser Ser Ser Val Lys Leu Asn Ile Ser 
        515                 520                 525             


Ser Lys Asp Asn Arg Gly Gly Ile Lys Ser Lys Thr Thr Ala Lys Val 
    530                 535                 540                 


Thr Lys Glu Leu Tyr Val Lys Leu Thr Pro Val Ser Leu Ser Asn Ser 
545                 550                 555                 560 


Pro Ile Lys Gly Ala Asp Cys Gln Glu Val Pro Gln Asp Lys Asp Gly 
                565                 570                 575     


Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu Glu Lys Cys Gly Leu Gly 
            580                 585                 590         


Gln Glu Asn Ser Asp Asn Glu His Leu Val Glu Asn Glu Val Ser Leu 
        595                 600                 605             


Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser Pro Arg Val Lys Thr Thr 
    610                 615                 620                 


Pro Leu Arg Arg Pro Thr Glu Thr Asn Pro Val Thr Ser Asn Ser Asp 
625                 630                 635                 640 


Glu Glu Cys Asn Glu Thr Val Lys Glu Lys Gln Lys Leu Ser Val Pro 
                645                 650                 655     


Val Arg Lys Lys Asp Lys Arg Asn Ser Ser Asp Ser Ala Ile Asp Asn 
            660                 665                 670         


Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys Gln Ser Glu Thr Val Asp 
        675                 680                 685             


Gln Asn Ser Asp Ser Asp Glu Met Leu Ala Ile Leu Lys Glu Val Ser 
    690                 695                 700                 


Arg Met Ser His Ser Ser Ser Ser Asp Thr Asp Ile Asn Glu Ile His 
705                 710                 715                 720 


Thr Asn His Lys Thr Leu Tyr Asp Leu Lys Thr Gln Ala Gly Lys Asp 
                725                 730                 735     


Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser Thr Ser Gly Ser Asp Phe 
            740                 745                 750         


Asp Thr Lys Lys Gly Lys Ser Ala Lys Ser Ser Ile Ile Ser Lys Lys 
        755                 760                 765             


Lys Arg Gln Thr Gln Ser Glu Ser Ser Asn Tyr Asp Ser Glu Leu Glu 
    770                 775                 780                 


Lys Glu Ile Lys Ser Met Ser Lys Ile Gly Ala Ala Arg Thr Thr Lys 
785                 790                 795                 800 


Lys Arg Ile Pro Asn Thr Lys Asp Phe Asp Ser Ser Glu Asp Glu Lys 
                805                 810                 815     


His Ser Lys Lys Gly Met Asp Asn Gln Gly His Lys Asn Leu Lys Thr 
            820                 825                 830         


Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu Arg Lys Gln Glu Arg Glu 
        835                 840                 845             


Thr Phe Ser Ser Ala Glu Gly Thr Val Asp Lys Asp Thr Thr Ile Met 
    850                 855                 860                 


Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln Gln Ala Ser Ala Ser Thr 
865                 870                 875                 880 


Asp Gly Val Asp Lys Leu Ser Gly Lys Glu Gln Ser Phe Thr Ser Leu 
                885                 890                 895     


Glu Val Arg Lys Val Ala Glu Thr Lys Glu Lys Ser Lys His Leu Lys 
            900                 905                 910         


Thr Lys Thr Cys Lys Lys Val Gln Asp Gly Leu Ser Asp Ile Ala Glu 
        915                 920                 925             


Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu Thr Ser Glu Asp Asp Lys 
    930                 935                 940                 


Lys Gln Ser Lys Lys Gly Thr Glu Glu Lys Lys Lys Pro Ser Asp Phe 
945                 950                 955                 960 


Lys Lys Lys Val Ile Lys Met Glu Gln Gln Tyr Glu Ser Ser Ser Asp 
                965                 970                 975     


Gly Thr Glu Lys Leu Pro Glu Arg Glu Glu Ile Cys His Phe Pro Lys 
            980                 985                 990         


Gly Ile Lys Gln Ile Lys Asn Gly  Thr Thr Asp Gly Glu  Lys Lys Ser 
        995                 1000                 1005             


Lys Lys  Ile Arg Asp Lys Thr  Ser Lys Lys Lys Asp  Glu Leu Ser 
    1010                 1015                 1020             


Asp Tyr  Ala Glu Lys Ser Thr  Gly Lys Gly Asp Ser  Cys Asp Ser 
    1025                 1030                 1035             


Ser Glu  Asp Lys Lys Ser Lys  Asn Gly Ala Tyr Gly  Arg Glu Lys 
    1040                 1045                 1050             


Lys Arg  Cys Lys Leu Leu Gly  Lys Ser Ser Arg Lys  Arg Gln Asp 
    1055                 1060                 1065             


Cys Ser  Ser Ser Asp Thr Glu  Lys Tyr Ser Met Lys  Glu Asp Gly 
    1070                 1075                 1080             


Cys Asn  Ser Ser Asp Lys Arg  Leu Lys Arg Ile Glu  Leu Arg Glu 
    1085                 1090                 1095             


Arg Arg  Asn Leu Ser Ser Lys  Arg Asn Thr Lys Glu  Ile Gln Ser 
    1100                 1105                 1110             


Gly Ser  Ser Ser Ser Asp Ala  Glu Glu Ser Ser Glu  Asp Asn Lys 
    1115                 1120                 1125             


Lys Lys  Lys Gln Arg Thr Ser  Ser Lys Lys Lys Ala  Val Ile Val 
    1130                 1135                 1140             


Lys Glu  Lys Lys Arg Asn Ser  Leu Arg Thr Ser Thr  Lys Arg Lys 
    1145                 1150                 1155             


Gln Ala  Asp Ile Thr Ser Ser  Ser Ser Ser Asp Ile  Glu Asp Asp 
    1160                 1165                 1170             


Asp Gln  Asn Ser Ile Gly Glu  Gly Ser Ser Asp Glu  Gln Lys Ile 
    1175                 1180                 1185             


Lys Pro  Val Thr Glu Asn Leu  Val Leu Ser Ser His  Thr Gly Phe 
    1190                 1195                 1200             


Cys Gln  Ser Ser Gly Asp Glu  Ala Leu Ser Lys Ser  Val Pro Val 
    1205                 1210                 1215             


Thr Val  Asp Asp Asp Asp Asp  Asp Asn Asp Pro Glu  Asn Arg Ile 
    1220                 1225                 1230             


Ala Lys  Lys Met Leu Leu Glu  Glu Ile Lys Ala Asn  Leu Ser Ser 
    1235                 1240                 1245             


Asp Glu  Asp Gly Ser Ser Asp  Asp Glu Pro Glu Glu  Gly Lys Lys 
    1250                 1255                 1260             


Arg Thr  Gly Lys Gln Asn Glu  Glu Asn Pro Gly Asp  Glu Glu Ala 
    1265                 1270                 1275             


Lys Asn  Gln Val Asn Ser Glu  Ser Asp Ser Asp Ser  Glu Glu Ser 
    1280                 1285                 1290             


Lys Lys  Pro Arg Tyr Arg His  Arg Leu Leu Arg His  Lys Leu Thr 
    1295                 1300                 1305             


Val Ser  Asp Gly Glu Ser Gly  Glu Glu Lys Lys Thr  Lys Pro Lys 
    1310                 1315                 1320             


Glu His  Lys Glu Val Lys Gly  Arg Asn Arg Arg Lys  Val Ser Ser 
    1325                 1330                 1335             


Glu Asp  Ser Glu Asp Ser Asp  Phe Gln Glu Ser Gly  Val Ser Glu 
    1340                 1345                 1350             


Glu Val  Ser Glu Ser Glu Asp  Glu Gln Arg Pro Arg  Thr Arg Ser 
    1355                 1360                 1365             


Ala Lys  Lys Ala Glu Leu Glu  Glu Asn Gln Arg Ser  Tyr Lys Gln 
    1370                 1375                 1380             


Lys Lys  Lys Arg Arg Arg Ile  Lys Val Gln Glu Asp  Ser Ser Ser 
    1385                 1390                 1395             


Glu Asn  Lys Ser Asn Ser Glu  Glu Glu Glu Glu Glu  Lys Glu Glu 
    1400                 1405                 1410             


Glu Glu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Glu  Glu Asp Glu 
    1415                 1420                 1425             


Asn Asp  Asp Ser Lys Ser Pro  Gly Lys Gly Arg Lys  Lys Ile Arg 
    1430                 1435                 1440             


Lys Ile  Leu Lys Asp Asp Lys  Leu Arg Thr Glu Thr  Gln Asn Ala 
    1445                 1450                 1455             


Leu Lys  Glu Glu Glu Glu Arg  Arg Lys Arg Ile Ala  Glu Arg Glu 
    1460                 1465                 1470             


Arg Glu  Arg Glu Lys Leu Arg  Glu Val Ile Glu Ile  Glu Asp Ala 
    1475                 1480                 1485             


Ser Pro  Thr Lys Cys Pro Ile  Thr Thr Lys Leu Val  Leu Asp Glu 
    1490                 1495                 1500             


Asp Glu  Glu Thr Lys Glu Pro  Leu Val Gln Val His  Arg Asn Met 
    1505                 1510                 1515             


Val Ile  Lys Leu Lys Pro His  Gln Val Asp Gly Val  Gln Phe Met 
    1520                 1525                 1530             


Trp Asp  Cys Cys Cys Glu Ser  Val Lys Lys Thr Lys  Lys Ser Pro 
    1535                 1540                 1545             


Gly Ser  Gly Cys Ile Leu Ala  His Cys Met Gly Leu  Gly Lys Thr 
    1550                 1555                 1560             


Leu Gln  Val Val Ser Phe Leu  His Thr Val Leu Leu  Cys Asp Lys 
    1565                 1570                 1575             


Leu Asp  Phe Ser Thr Ala Leu  Val Val Cys Pro Leu  Asn Thr Ala 
    1580                 1585                 1590             


Leu Asn  Trp Met Asn Glu Phe  Glu Lys Trp Gln Glu  Gly Leu Lys 
    1595                 1600                 1605             


Asp Asp  Glu Lys Leu Glu Val  Ser Glu Leu Ala Thr  Val Lys Arg 
    1610                 1615                 1620             


Pro Gln  Glu Arg Ser Tyr Met  Leu Gln Arg Trp Gln  Glu Asp Gly 
    1625                 1630                 1635             


Gly Val  Met Ile Ile Gly Tyr  Glu Met Tyr Arg Asn  Leu Ala Gln 
    1640                 1645                 1650             


Gly Arg  Asn Val Lys Ser Arg  Lys Leu Lys Glu Ile  Phe Asn Lys 
    1655                 1660                 1665             


Ala Leu  Val Asp Pro Gly Pro  Asp Phe Val Val Cys  Asp Glu Gly 
    1670                 1675                 1680             


His Ile  Leu Lys Asn Glu Ala  Ser Ala Val Ser Lys  Ala Met Asn 
    1685                 1690                 1695             


Ser Ile  Arg Ser Arg Arg Arg  Ile Ile Leu Thr Gly  Thr Pro Leu 
    1700                 1705                 1710             


Gln Asn  Asn Leu Ile Glu Tyr  His Cys Met Val Asn  Phe Ile Lys 
    1715                 1720                 1725             


Glu Asn  Leu Leu Gly Ser Ile  Lys Glu Phe Arg Asn  Arg Phe Ile 
    1730                 1735                 1740             


Asn Pro  Ile Gln Asn Gly Gln  Cys Ala Asp Ser Thr  Met Val Asp 
    1745                 1750                 1755             


Val Arg  Val Met Lys Lys Arg  Ala His Ile Leu Tyr  Glu Met Leu 
    1760                 1765                 1770             


Ala Gly  Cys Val Gln Arg Lys  Asp Tyr Thr Ala Leu  Thr Lys Phe 
    1775                 1780                 1785             


Leu Pro  Pro Lys His Glu Tyr  Val Leu Ala Val Arg  Met Thr Ser 
    1790                 1795                 1800             


Ile Gln  Cys Lys Leu Tyr Gln  Tyr Tyr Leu Asp His  Leu Thr Gly 
    1805                 1810                 1815             


Val Gly  Asn Asn Ser Glu Gly  Gly Arg Gly Lys Ala  Gly Ala Lys 
    1820                 1825                 1830             


Leu Phe  Gln Asp Phe Gln Met  Leu Ser Arg Ile Trp  Thr His Pro 
    1835                 1840                 1845             


Trp Cys  Leu Gln Leu Asp Tyr  Ile Ser Lys Glu Asn  Lys Gly Tyr 
    1850                 1855                 1860             


Phe Asp  Glu Asp Ser Met Asp  Glu Phe Ile Ala Ser  Asp Ser Asp 
    1865                 1870                 1875             


Glu Thr  Ser Met Ser Leu Ser  Ser Asp Asp Tyr Thr  Lys Lys Lys 
    1880                 1885                 1890             


Lys Lys  Gly Lys Lys Gly Lys  Lys Asp Ser Ser Ser  Ser Gly Ser 
    1895                 1900                 1905             


Gly Ser  Asp Asn Asp Val Glu  Val Ile Lys Val Trp  Asn Ser Arg 
    1910                 1915                 1920             


Ser Arg  Gly Gly Gly Glu Gly  Asn Val Asp Glu Thr  Gly Asn Asn 
    1925                 1930                 1935             


Pro Ser  Val Ser Leu Lys Leu  Glu Glu Ser Lys Ala  Thr Ser Ser 
    1940                 1945                 1950             


Ser Asn  Pro Ser Ser Pro Ala  Pro Asp Trp Tyr Lys  Asp Phe Val 
    1955                 1960                 1965             


Thr Asp  Ala Asp Ala Glu Val  Leu Glu His Ser Gly  Lys Met Val 
    1970                 1975                 1980             


Leu Leu  Phe Glu Ile Leu Arg  Met Ala Glu Glu Ile  Gly Asp Lys 
    1985                 1990                 1995             


Val Leu  Val Phe Ser Gln Ser  Leu Ile Ser Leu Asp  Leu Ile Glu 
    2000                 2005                 2010             


Asp Phe  Leu Glu Leu Ala Ser  Arg Glu Lys Thr Glu  Asp Lys Asp 
    2015                 2020                 2025             


Lys Pro  Leu Ile Tyr Lys Gly  Glu Gly Lys Trp Leu  Arg Asn Ile 
    2030                 2035                 2040             


Asp Tyr  Tyr Arg Leu Asp Gly  Ser Thr Thr Ala Gln  Ser Arg Lys 
    2045                 2050                 2055             


Lys Trp  Ala Glu Glu Phe Asn  Asp Glu Thr Asn Val  Arg Gly Arg 
    2060                 2065                 2070             


Leu Phe  Ile Ile Ser Thr Lys  Ala Gly Ser Leu Gly  Ile Asn Leu 
    2075                 2080                 2085             


Val Ala  Ala Asn Arg Val Ile  Ile Phe Asp Ala Ser  Trp Asn Pro 
    2090                 2095                 2100             


Ser Tyr  Asp Ile Gln Ser Ile  Phe Arg Val Tyr Arg  Phe Gly Gln 
    2105                 2110                 2115             


Thr Lys  Pro Val Tyr Val Tyr  Arg Phe Leu Ala Gln  Gly Thr Met 
    2120                 2125                 2130             


Glu Asp  Lys Ile Tyr Asp Arg  Gln Val Thr Lys Gln  Ser Leu Ser 
    2135                 2140                 2145             


Phe Arg  Val Val Asp Gln Gln  Gln Val Glu Arg His  Phe Thr Met 
    2150                 2155                 2160             


Asn Glu  Leu Thr Glu Leu Tyr  Thr Phe Glu Pro Asp  Leu Leu Asp 
    2165                 2170                 2175             


Asp Pro  Asn Ser Glu Lys Lys  Lys Lys Arg Asp Thr  Pro Met Leu 
    2180                 2185                 2190             


Pro Lys  Asp Thr Ile Leu Ala  Glu Leu Leu Gln Ile  His Lys Glu 
    2195                 2200                 2205             


His Ile  Val Gly Tyr His Glu  His Asp Ser Leu Leu  Asp His Lys 
    2210                 2215                 2220             


Glu Glu  Glu Glu Leu Thr Glu  Glu Glu Arg Lys Ala  Ala Trp Ala 
    2225                 2230                 2235             


Glu Tyr  Glu Ala Glu Lys Lys  Gly Leu Thr Met Arg  Phe Asn Ile 
    2240                 2245                 2250             


Pro Thr  Gly Thr Asn Leu Pro  Pro Val Ser Phe Asn  Ser Gln Thr 
    2255                 2260                 2265             


Pro Tyr  Ile Pro Phe Asn Leu  Gly Ala Leu Ser Ala  Met Ser Asn 
    2270                 2275                 2280             


Gln Gln  Leu Glu Asp Leu Ile  Asn Gln Gly Arg Glu  Lys Val Val 
    2285                 2290                 2295             


Glu Ala  Thr Asn Ser Val Thr  Ala Val Arg Ile Gln  Pro Leu Glu 
    2300                 2305                 2310             


Asp Ile  Ile Ser Ala Val Trp  Lys Glu Asn Met Asn  Leu Ser Glu 
    2315                 2320                 2325             


Ala Gln  Val Gln Ala Leu Ala  Leu Ser Arg Gln Ala  Ser Gln Glu 
    2330                 2335                 2340             


Leu Asp  Val Lys Arg Arg Glu  Ala Ile Tyr Asn Asp  Val Leu Thr 
    2345                 2350                 2355             


Lys Gln  Gln Met Leu Ile Ser  Cys Val Gln Arg Ile  Leu Met Asn 
    2360                 2365                 2370             


Arg Arg  Leu Gln Gln Gln Tyr  Asn Gln Gln Gln Gln  Gln Gln Met 
    2375                 2380                 2385             


Thr Tyr  Gln Gln Ala Thr Leu  Gly His Leu Met Met  Pro Lys Pro 
    2390                 2395                 2400             


Pro Asn  Leu Ile Met Asn Pro  Ser Asn Tyr Gln Gln  Ile Asp Met 
    2405                 2410                 2415             


Arg Gly  Met Tyr Gln Pro Val  Ala Gly Gly Met Gln  Pro Pro Pro 
    2420                 2425                 2430             


Leu Gln  Arg Ala Pro Pro Pro  Met Arg Ser Lys Asn  Pro Gly Pro 
    2435                 2440                 2445             


Ser Gln  Gly Lys Ser Met 
    2450                 


<210>  8
<211>  11088
<212>  DNA
<213>  Homo sapiens

<400>  8
aattctcctg cctgagcctc ggcccaacaa aatggcggcg gcagcggtgt cgctttgttt       60

ccgcggctcc tgcggcggtg gcagtggtag cggcctttga gctgtgggga ggttccagca      120

gcagctacag tgacgactaa gactccagtg catttctatc gtaaccgggc gcgggggagc      180

gcagatcggc gcccagcaat cacagaagcc gacaaggcgt tcaagcgaaa acatgaccgc      240

tgagcccatg agtgaaagca agttgaatac attggtgcag aagcttcatg acttccttgc      300

acactcatca gaagaatctg aagaaacaag ttctcctcca cgacttgcaa tgaatcaaaa      360

cacagataaa atcagtggtt ctggaagtaa ctctgatatg atggaaaaca gcaaggaaga      420

gggaactagc tcttcagaaa aatccaagtc ttcaggatcg tcacgatcaa agaggaaacc      480

ttcaattgta acaaagtatg tagaatcaga tgatgaaaaa cctttggatg atgaaactgt      540

aaatgaagat gcgtctaatg aaaattcaga aaatgatatt actatgcaga gcttgccaaa      600

agaagatggg cttcatggga ttgtgagctg cactgcttgt ggacaacagg tcaatcattt      660

tcaaaaagat tccatttata gacacccttc attgcaagtt cttatttgta agaattgctt      720

taagtattac atgagtgatg atattagccg tgactcagat ggaatggatg aacaatgtag      780

gtggtgtgcg gaaggtggaa acttgatttg ttgtgacttt tgccataatg ctttctgcaa      840

gaaatgcatt ctacgcaacc ttggtcgaaa ggagttgtcc acaataatgg atgaaaacaa      900

ccaatggtat tgctacattt gtcacccaga gcctttgttg gacttggtca ctgcatgtaa      960

cagcgtattt gagaatttag aacagttgtt gcagcaaaat aagaagaaga taaaagttga     1020

cagtgaaaag agtaataaag tatatgaaca tacatccaga ttttctccaa agaagactag     1080

ttcaaattgt aatggagaag aaaagaaatt agatgattcc tgttctggct ctgtaaccta     1140

ctcttattcc gcactaattg tgcccaaaga gatgattaag aaggcaaaaa aactgattga     1200

gaccacagcc aacatgaact ccagttatgt taaattttta aagcaggcaa cagataattc     1260

agaaatcagt tctgctacaa aattacgtca gcttaaggct tttaagtctg tgttggctga     1320

tattaagaag gctcatcttg cattggaaga agacttaaat tccgagtttc gagcgatgga     1380

tgctgtaaac aaagagaaaa ataccaaaga gcataaagtc atagatgcta agtttgaaac     1440

aaaagcacga aaaggagaaa aaccttgtgc tttggaaaag aaggatattt caaagtcaga     1500

agctaaactt tcaagaaaac aggtagatag tgagcacatg catcagaatg ttccaacaga     1560

ggaacaaaga acaaataaaa gtaccggtgg tgaacataag aaatctgata gaaaagaaga     1620

acctcaatat gaacctgcca acacttctga agatttagac atggatattg tgtctgttcc     1680

ttcctcagtt ccagaagaca tttttgagaa tcttgagact gctatggaag ttcagagttc     1740

agttgatcat caaggggatg gcagcagtgg aactgaacaa gaagtggaga gttcatctgt     1800

aaaattaaat atttcttcaa aagacaacag aggaggtatt aaatcaaaaa ctacagctaa     1860

agtaacaaaa gaattatatg ttaaactcac tcctgtttcc ctttctaatt ccccaattaa     1920

aggtgctgat tgtcaggaag ttccacaaga taaagatggc tataaaagtt gtggtctgaa     1980

ccccaagtta gagaaatgtg gacttggaca ggaaaacagt gataatgagc atttggttga     2040

aaatgaagtt tcattacttt tagaggaatc tgatcttcga agatccccac gtgtaaagac     2100

tacacccttg aggcgaccga cagaaactaa ccctgtaaca tctaattcag atgaagaatg     2160

taatgaaaca gttaaggaga aacaaaaact atcagttcca gtgagaaaaa aggataagcg     2220

taattcttct gacagtgcta tagataatcc taagcctaat aaattgccaa aatctaagca     2280

atcagagact gtggatcaaa attcagattc tgatgaaatg ctagcaatcc tcaaagaggt     2340

gagcaggatg agtcacagtt cttcttcaga tactgatatt aatgaaattc atacaaacca     2400

taagactttg tatgatttaa agactcaggc ggggaaagat gataaaggaa aaaggaaacg     2460

aaaaagttct acatctggct cagattttga tactaaaaag ggcaaatcag ctaagagctc     2520

tataatttct aaaaagaaac gacaaaccca gtctgagtct tctaattatg actcagaatt     2580

agaaaaagag ataaagagca tgagtaaaat tggtgctgcc agaaccacca aaaaaagaat     2640

tccaaataca aaagattttg actcttctga agatgagaaa cacagcaaaa aaggaatgga     2700

taatcaaggg cacaaaaatt tgaagacctc acaagaagga tcatctgatg atgctgaaag     2760

aaaacaagag agagagactt tctcttcagc agaaggcaca gttgataaag acacgaccat     2820

catggaatta agagatcgac ttcctaagaa gcagcaagca agtgcttcca ctgatggtgt     2880

cgataagctt tctgggaaag agcagagttt tacttctttg gaagttagaa aagttgctga     2940

aactaaagaa aagagcaagc atctcaaaac caaaacatgt aaaaaagtac aggatggctt     3000

atctgatatt gcagagaaat tcctaaagaa agaccagagc gatgaaactt ctgaagatga     3060

taaaaagcag agcaaaaagg gaactgaaga aaaaaagaaa ccttcagact ttaagaaaaa     3120

agtaattaaa atggaacaac agtatgaatc ttcatctgat ggcactgaaa agttacctga     3180

gcgagaagaa atttgtcatt ttcctaaggg cataaaacaa attaagaatg gaacaactga     3240

tggagaaaag aaaagtaaaa aaataagaga taaaacttct aaaaagaagg atgaattatc     3300

tgattatgct gagaagtcaa cagggaaagg agatagttgt gactcttcag aggataaaaa     3360

gagtaagaat ggagcatatg gtagagagaa gaaaaggtgc aagttgcttg gaaagagttc     3420

aaggaagaga caagattgtt catcatctga tactgagaaa tattccatga aagaagatgg     3480

ttgtaactct tctgataaga gactgaaaag aatagaattg agggaaagaa gaaatttaag     3540

ttcaaagaga aatactaagg aaatacaaag tggctcatca tcatctgatg ctgaggaaag     3600

ttctgaagat aataaaaaga agaagcaaag aacttcatct aaaaagaagg cagtcattgt     3660

caaggagaaa aagagaaact ccctaagaac aagcactaaa aggaagcaag ctgacattac     3720

atcctcatct tcttctgata tagaagatga tgatcagaat tctataggtg agggaagcag     3780

cgatgaacag aaaattaagc ctgtgactga aaatttagtg ctgtcttcac atactggatt     3840

ttgccaatct tcaggagatg aagccttatc taaatcagtg cctgtcacag tggatgatga     3900

tgatgacgac aatgatcctg agaatagaat tgccaagaag atgcttttag aagaaattaa     3960

agccaatctt tcctctgatg aggatggatc ttcagatgat gagccagaag aagggaaaaa     4020

aagaactgga aaacaaaatg aagaaaaccc aggagatgag gaagcaaaaa atcaagtcaa     4080

ttctgaatca gattcagatt ctgaagaatc taagaagcca agatacagac ataggctttt     4140

gcggcacaaa ttgactgtga gtgacggaga atctggagaa gaaaaaaaga caaagcctaa     4200

agagcataaa gaagtcaaag gcagaaacag aagaaaggtg agcagtgaag attcagaaga     4260

ttctgatttt caggaatcag gagttagtga agaagttagt gaatccgaag atgaacagcg     4320

gcccagaaca aggtctgcaa agaaagcaga gttggaagaa aatcagcgga gctataaaca     4380

gaaaaagaaa aggcgacgta ttaaggttca agaagattca tccagtgaaa acaagagtaa     4440

ttctgaggaa gaagaggagg aaaaagaaga ggaggaggaa gaggaggagg aggaggaaga     4500

ggaggaggaa gatgaaaatg atgattccaa gtctcctgga aaaggcagaa agaaaattcg     4560

gaagattctt aaagatgata aactgagaac agaaacacaa aatgctctta aggaagagga     4620

agagagacga aaacgtattg ctgagaggga gcgtgagcga gaaaaattga gagaggtgat     4680

agaaattgaa gatgcttcac ccaccaagtg tccaataaca accaagttgg ttttagatga     4740

agatgaagaa accaaagaac ctttagtgca ggttcataga aatatggtta tcaaattgaa     4800

accccatcaa gtagatggtg ttcagtttat gtgggattgc tgctgtgagt ctgtgaaaaa     4860

aacaaagaaa tctccaggtt caggatgcat tcttgcccac tgtatgggcc ttggtaagac     4920

tttacaggtg gtaagttttc ttcatacagt tcttttgtgt gacaaactgg atttcagcac     4980

ggcgttagtg gtttgtcctc ttaatactgc tttgaattgg atgaatgaat ttgagaagtg     5040

gcaagaggga ttaaaagatg atgagaagct tgaggtttct gaattagcaa ctgtgaaacg     5100

tcctcaggag agaagctaca tgctgcagag gtggcaagaa gatggtggtg ttatgatcat     5160

aggctatgag atgtatagaa atcttgctca aggaaggaat gtgaagagtc ggaaacttaa     5220

agaaatattt aacaaagctt tggttgatcc aggccctgat tttgttgttt gtgatgaagg     5280

ccatattcta aaaaatgaag catctgctgt ttctaaagct atgaattcta tacgatcaag     5340

gaggaggatt attttaacag gaacaccact tcaaaataac ctaattgagt atcattgtat     5400

ggttaatttt atcaaggaaa atttacttgg atccattaag gagttcagga atagatttat     5460

aaatccaatt caaaatggtc agtgtgcaga ttctaccatg gtagatgtca gagtgatgaa     5520

aaaacgtgct cacattctct atgagatgtt agctggatgt gttcagagga aagattatac     5580

agcattaaca aaattcttgc ctccaaaaca cgaatatgtg ttagctgtga gaatgacttc     5640

tattcagtgc aagctctatc agtactactt agatcactta acaggtgtgg gcaataatag     5700

tgaaggtgga agaggaaagg caggtgcaaa gcttttccaa gattttcaga tgttaagtag     5760

aatatggact catccttggt gtttgcagct agactacatt agcaaagaaa ataagggtta     5820

ttttgatgaa gacagtatgg atgaatttat agcctcagat tctgatgaaa cctccatgag     5880

tttaagctcc gatgattata caaaaaagaa gaaaaaaggg aaaaagggga aaaaagatag     5940

tagctcaagt ggaagtggca gtgacaatga tgttgaagtg attaaggtct ggaattcaag     6000

atctcgggga ggtggtgaag gaaatgtgga tgaaacagga aacaatcctt ctgtttcttt     6060

aaaactggaa gaaagtaaag ctacttcttc ttctaatcca agcagcccag ctccagactg     6120

gtacaaagat tttgttacag atgctgatgc tgaggtttta gagcattctg ggaaaatggt     6180

acttctcttt gaaattcttc gaatggcaga ggaaattggg gataaagtcc ttgttttcag     6240

ccagtccctc atatctctgg acttgattga agattttctt gaattagcta gtagggagaa     6300

gacagaagat aaagataaac cccttattta taaaggtgag gggaagtggc ttcgaaacat     6360

tgactattac cgtttagatg gttccactac tgcacagtca aggaagaagt gggctgaaga     6420

atttaatgat gaaactaatg tgagaggacg attatttatc atttctacta aagcaggatc     6480

tctaggaatt aatctggtag ctgctaatcg agtaattata ttcgacgctt cttggaatcc     6540

atcttatgac atccagagta tattcagagt ttatcgcttt ggacaaacta agcctgttta     6600

tgtatatagg ttcttagctc agggaaccat ggaagataag atttatgatc ggcaagtaac     6660

taagcagtca ctgtcttttc gagttgttga tcagcagcag gtggagcgtc attttactat     6720

gaatgagctt actgaacttt atacttttga gccagactta ttagatgacc ctaattcaga     6780

aaagaagaag aagagggata ctcccatgct gccaaaggat accatacttg cagagctcct     6840

tcagatacat aaagaacaca ttgtaggata ccatgaacat gattctcttt tggaccacaa     6900

agaagaagaa gagttgactg aagaagaaag aaaagcagct tgggctgagt atgaagcaga     6960

gaagaaggga ctgaccatgc gtttcaacat accaactggg accaatttac cccctgtcag     7020

tttcaactct caaactcctt atattccttt caatttggga gccctgtcag caatgagtaa     7080

tcaacagctg gaggacctca ttaatcaagg aagagaaaaa gttgtagaag caacaaacag     7140

tgtgacagca gtgaggattc aacctcttga ggatataatt tcagctgtat ggaaggagaa     7200

catgaatctc tcagaggccc aagtacaggc gttagcatta agtagacaag ccagccagga     7260

gcttgatgtt aaacgaagag aagcaatcta caatgatgta ttgacaaaac aacagatgtt     7320

aatcagctgt gttcagcgaa tacttatgaa cagaaggctc cagcagcagt acaatcagca     7380

gcaacagcaa caaatgactt atcaacaagc aacactgggt cacctcatga tgccaaagcc     7440

cccaaatttg atcatgaatc cttctaacta ccagcagatt gatatgagag gaatgtatca     7500

gccagtggct ggtggtatgc agccaccacc attacagcgt gcaccacccc caatgagaag     7560

caaaaatcca ggaccttccc aagggaaatc aatgtgattt tgcactaaaa gcttaatgga     7620

ttgttaaaat catagaaaga tcttttattt ttttaggaat caatgactta acagaactca     7680

actgtataaa tagtttggtc cccttaaatg ccaatcttcc atattagttt tacttttttt     7740

ttttttaaat agggcatacc atttcttcct gacatttgtc agtgatgttg cctagaatct     7800

tcttacacac gctgagtaca gaagatattt caaattgttt tcagtgaaaa caagtccttc     7860

cataatagta acaactccac agatttcctc tctaaatttt tatgcctgct tttagcaacc     7920

ataaaattgt cataaaatta ataaatttag gaaagaataa agatttatat attcattctt     7980

tacatataaa aacacacagc tgagttctta gagttgattc ctcaagttat gaaatacttt     8040

tgtacttaat ccatttcttg attaaagtga ttgaaatggt tttaatgttc ttttgactga     8100

agtctgaaac tgggctcctg ctttattgtc tctgtgactg aaagttagaa actgagggtt     8160

atctttgaca cagaattgtg tgcaatattc ttaaatacta ctgctctaaa agttggagaa     8220

gtcttgcagt tatcttagca ttgtataaac agccttaagt atagcctaag aagagaattc     8280

ctttttcttc tttagtcctt ctgccatttt ttattttcag ttatatgtgc tgaaataatt     8340

actggtaaaa tttcagggtt gtggattatc ttccacacat gaattttctc tctcctggca     8400

cgaatataaa gcacatctct taactgcatg gtgccagtgc taatgcttca tcctgttgct     8460

ggcagtggga tgtggactta gaaaatcaag ttctagcatt ttagtaggtt aacactgaag     8520

ttgtggttgt taggttcaca ccctgtttta taaacaacat caaaatggca gaaccattgc     8580

tgactttagg ttcacatgag gaatgtactt ttaacaattc ccagtactat cagtattgtg     8640

aaataattcc tctgaaagat aagaatcact ggcttctatg cgcttctttt ctctcatcat     8700

catgttcttt taccccagtt tccttacatt tttttaaatt gtttcagagt ttgttttttt     8760

tttagtttag attgtgaggc aattattaaa tcaaaattaa ttcatccaat acccctttac     8820

tagaagtttt actagaaaat gtattacatt ttattttttc ttaatccagt tctgcaaaaa     8880

tgacctataa atttattcat gtacaatttt ggttacttga attgttaaag aaaacattgt     8940

ttttgactat gggagtcaac tcaacatggc agaaccattt ttgagatgat gatacaacag     9000

gtagtgaaac agcttaagaa ttccaaaaaa aaaaaaaaaa aaaaaaaaaa gaaaactggg     9060

tttgggcttt gctttaggta tcactggatt agaatgagtt taacattagc taaaactgct     9120

ttgagttgtt tggatgatta agagattgcc atttttatct tggaagaact agtggtaaaa     9180

catccaagag cactaggatt gtgatacaga atttgtgagg tttggtggat ccacgcccct     9240

ctcccccact ttcccatgat gaaatatcac taataaatcc tgtatattta gatattatgc     9300

tagccatgta atcagattta tttaattggg tggggcaggt gtgtatttac tttagaaaaa     9360

atgaaaaaga caagatttat gagaaatatt tgaaggcagt acactctggc caactgttac     9420

cagttggtat ttctacaagt tcagaatatt ttaaacctga tttactagac ctgggaattt     9480

tcaacatggt ctaattattt actcaaagac atagatgtga aaattttagg caaccttcta     9540

aatctttttc accatggatg aaactataac ttaaagaata atacttagaa gggttaattg     9600

gaaatcagag tttgaaataa aacttggacc actttgtata cactcttctc acttgacatt     9660

ttagctatat aatatgtact ttgagtataa catcaagctt taacaaatat ttaaagacaa     9720

aaaaatcacg tcagtaaaat actaaaaggc tcatttttat atttgtttta gatgttttaa     9780

atagttgcaa tggattaaaa atgatgattt aaaatgttgc ttgtaataca gttttgcctg     9840

ctaaattctc cacattttgt aacctgtttt atttctttgg gtgtaaagcg tttttgctta     9900

gtattgtgat attgtatatg ttttgtccca gttgtatagt aatgtttcag tccatcatcc     9960

agctttggct gctgaaatca tacagctgtg aagacttgcc tttgtttctg ttagactgct    10020

tttcagttct gtattgagta tcttaagtac tgtagaaaag atgtcacttc ttcctttaag    10080

gctgttttgt aatatatata aggactggaa ttgtgttttt aaagaaaagc attcaagtat    10140

gacaatatac tatctgtgtt ttcaccattc aaagtgctgt ttagtagttg aaacttaaac    10200

tatttaatgt catttaataa agtgaccaaa atgtgttgtg ctctttattg tattttcaca    10260

gctttgaaaa tctgtgcaca tactgtttca tagaaaatgt atagcttttg ttgtcctata    10320

taatggtggt tcttttgcac atttagttat ttaatattga gaggtcacga agtttggtta    10380

ttgaatctgt tatatactaa attctgtaaa gggagatctc tcatctcaaa aagaatttac    10440

ataccaggaa gtccatgtgt gtttgtgtta gttttggatg tctttgtgta atccagcccc    10500

atttcctgtt tcccaacagc tgtaacactc attttaagtc aagcagggct accaacccac    10560

acttgataga aaagctgctt accattcaga agcttcctta ttacctggcc tccaaatgag    10620

ctgaatattt tgtagccttc ccttagctat gttcattttc cctccattat cataaaatca    10680

gatcgatatt tatgtgcccc aaacaaaact ttaagagcag ttacattctg tcccagtagc    10740

ccttgtttcc tttgagagta gcatgttgtg aggctataga gacttattct accagtaaaa    10800

caggtcaatc cttttacatg tttattatac taaaaattat gttcagggta tttactactt    10860

tatttcacca gactcagtct caagtgactt ggctatctcc aaatcagatc tacccttaga    10920

gaataaacat ttttctaccg ttattttttt tcaagtctat aatctgagcc agtcccaaag    10980

gagtgatcaa gtttcagaaa tgctttcatc ttcacaacat tttatatata ctattatatg    11040

gggtgaataa agttttaaat ccgaaatata aaaaaaaaaa aaaaaaaa                 11088


<210>  9
<211>  2285
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg 
            20                  25                  30          


Glu Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly 
        35                  40                  45              


Glu Met Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly 
    50                  55                  60                  


Pro Pro Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala 
                85                  90                  95      


Glu Pro Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala 
            100                 105                 110         


Leu Asn Asn Asn Leu Thr Glu Pro Pro Gly Gly Gly Gly Gly Gly Ser 
        115                 120                 125             


Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu Pro 
    130                 135                 140                 


Pro Pro Ala Tyr Gly Phe Gly Gln Pro Tyr Gly Arg Ser Pro Ser Ala 
145                 150                 155                 160 


Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly Gln 
                165                 170                 175     


Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly Leu 
            180                 185                 190         


Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe Pro 
        195                 200                 205             


Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro Pro 
    210                 215                 220                 


Pro Ala Pro Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Thr Pro Gly 
225                 230                 235                 240 


Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser Ser 
                245                 250                 255     


Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe Gly 
            260                 265                 270         


Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Thr Pro Gln 
        275                 280                 285             


Pro Thr Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Ser 
    290                 295                 300                 


Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Ser Gly Gly Pro 
305                 310                 315                 320 


Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln Cys 
                325                 330                 335     


Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly 
            340                 345                 350         


Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser Ser Gly 
        355                 360                 365             


Gly Gly Gly Gln Pro Leu Ala Arg Thr Pro Gln Pro Ser Ser Pro Met 
    370                 375                 380                 


Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Thr Asn Pro 
385                 390                 395                 400 


Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His Gly 
                405                 410                 415     


Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Thr Pro Gln Arg Tyr Pro Met 
            420                 425                 430         


Thr Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr Thr 
        435                 440                 445             


Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly Gln 
    450                 455                 460                 


Gln Gly Gln Thr Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln Gln 
465                 470                 475                 480 


Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Thr Pro His Ala 
                485                 490                 495     


Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu Gln 
            500                 505                 510         


Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His Gln 
        515                 520                 525             


Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Thr Thr Gln Gln His 
    530                 535                 540                 


Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro Tyr 
545                 550                 555                 560 


Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Thr Leu Ser Gln Gln 
                565                 570                 575     


Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Thr Ala Tyr 
            580                 585                 590         


Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser Phe 
        595                 600                 605             


Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Thr Ser Ser Lys Gly Gly 
    610                 615                 620                 


Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu Pro 
625                 630                 635                 640 


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Thr Glu Gly Ala 
                645                 650                 655     


Leu Ser Pro Gly Val Ser Thr Ser Gly Ile Ser Ser Ser Gln Gly Glu 
            660                 665                 670         


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Thr Ser Pro His 
        675                 680                 685             


Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala 
    690                 695                 700                 


Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro 
705                 710                 715                 720 


Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser Ile 
                725                 730                 735     


Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr 
            740                 745                 750         


Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly 
        755                 760                 765             


Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Thr Gly 
    770                 775                 780                 


Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly 
785                 790                 795                 800 


Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn 
                805                 810                 815     


Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile 
            820                 825                 830         


Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro 
        835                 840                 845             


Pro Tyr Gly Thr Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly 
    850                 855                 860                 


Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val Gly 
865                 870                 875                 880 


Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Thr Gln Glu 
                885                 890                 895     


Thr Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro 
            900                 905                 910         


Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Thr Gly Pro 
        915                 920                 925             


Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln 
    930                 935                 940                 


Gly Pro Pro Tyr Ser Met Gly Gly Thr Met Ala Asn Asn Ser Ala Gly 
945                 950                 955                 960 


Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Thr 
                965                 970                 975     


Pro Ala Thr Lys Met Asn Asn Lys Ala Asp Gly Thr Pro Lys Thr Glu 
            980                 985                 990         


Ser Lys Ser Lys Lys Ser Ser Ser  Ser Thr Thr Thr Asn  Glu Lys Ile 
        995                 1000                 1005             


Thr Lys  Leu Tyr Glu Leu Gly  Gly Glu Pro Glu Arg  Lys Met Trp 
    1010                 1015                 1020             


Val Asp  Arg Tyr Leu Ala Phe  Thr Glu Glu Lys Ala  Met Gly Met 
    1025                 1030                 1035             


Thr Asn  Leu Pro Ala Val Gly  Arg Lys Pro Leu Asp  Leu Tyr Arg 
    1040                 1045                 1050             


Leu Tyr  Val Ser Val Lys Glu  Ile Gly Gly Leu Thr  Gln Val Asn 
    1055                 1060                 1065             


Lys Asn  Lys Lys Trp Arg Glu  Leu Ala Thr Asn Leu  Asn Val Gly 
    1070                 1075                 1080             


Thr Ser  Ser Ser Ala Ala Ser  Ser Leu Lys Lys Gln  Tyr Ile Gln 
    1085                 1090                 1095             


Cys Leu  Tyr Ala Phe Glu Cys  Lys Ile Glu Arg Gly  Glu Asp Pro 
    1100                 1105                 1110             


Pro Pro  Asp Ile Phe Ala Ala  Ala Asp Ser Lys Lys  Ser Gln Pro 
    1115                 1120                 1125             


Lys Ile  Gln Pro Pro Ser Pro  Ala Gly Ser Gly Ser  Met Gln Gly 
    1130                 1135                 1140             


Pro Gln  Thr Pro Gln Ser Thr  Ser Ser Ser Met Ala  Glu Gly Gly 
    1145                 1150                 1155             


Asp Leu  Lys Pro Pro Thr Pro  Ala Ser Thr Pro His  Ser Gln Ile 
    1160                 1165                 1170             


Pro Pro  Leu Pro Gly Met Ser  Arg Ser Asn Ser Val  Gly Ile Gln 
    1175                 1180                 1185             


Asp Ala  Phe Asn Asp Gly Ser  Asp Ser Thr Phe Gln  Lys Arg Asn 
    1190                 1195                 1200             


Ser Met  Thr Pro Asn Pro Gly  Tyr Gln Pro Ser Met  Asn Thr Ser 
    1205                 1210                 1215             


Asp Met  Met Gly Arg Met Ser  Tyr Glu Pro Asn Lys  Asp Pro Tyr 
    1220                 1225                 1230             


Gly Ser  Met Arg Lys Ala Pro  Gly Ser Asp Pro Phe  Met Ser Ser 
    1235                 1240                 1245             


Gly Gln  Gly Pro Asn Gly Gly  Met Gly Asp Pro Tyr  Ser Arg Ala 
    1250                 1255                 1260             


Ala Gly  Pro Gly Leu Gly Asn  Val Ala Met Gly Pro  Arg Gln His 
    1265                 1270                 1275             


Tyr Pro  Tyr Gly Gly Pro Tyr  Asp Arg Val Arg Thr  Glu Pro Gly 
    1280                 1285                 1290             


Ile Gly  Pro Glu Gly Asn Met  Ser Thr Gly Ala Pro  Gln Pro Asn 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Pro Asp  Ser Gly Met Tyr Ser  Pro Ser Arg 
    1310                 1315                 1320             


Tyr Pro  Pro Gln Gln Gln Gln  Gln Gln Gln Gln Arg  His Asp Ser 
    1325                 1330                 1335             


Tyr Gly  Asn Gln Phe Ser Thr  Gln Gly Thr Pro Ser  Gly Ser Pro 
    1340                 1345                 1350             


Phe Pro  Ser Gln Gln Thr Thr  Met Tyr Gln Gln Gln  Gln Gln Asn 
    1355                 1360                 1365             


Tyr Lys  Arg Pro Met Asp Gly  Thr Tyr Gly Pro Pro  Ala Lys Arg 
    1370                 1375                 1380             


His Glu  Gly Glu Met Tyr Ser  Val Pro Tyr Ser Thr  Gly Gln Gly 
    1385                 1390                 1395             


Gln Pro  Gln Gln Gln Gln Leu  Pro Pro Ala Gln Pro  Gln Pro Ala 
    1400                 1405                 1410             


Ser Gln  Gln Gln Ala Ala Gln  Pro Ser Pro Gln Gln  Asp Val Tyr 
    1415                 1420                 1425             


Asn Gln  Tyr Gly Asn Ala Tyr  Pro Ala Thr Ala Thr  Ala Ala Thr 
    1430                 1435                 1440             


Glu Arg  Arg Pro Ala Gly Gly  Pro Gln Asn Gln Phe  Pro Phe Gln 
    1445                 1450                 1455             


Phe Gly  Arg Asp Arg Val Ser  Ala Pro Pro Gly Thr  Asn Ala Gln 
    1460                 1465                 1470             


Gln Asn  Met Pro Pro Gln Met  Met Gly Gly Pro Ile  Gln Ala Ser 
    1475                 1480                 1485             


Ala Glu  Val Ala Gln Gln Gly  Thr Met Trp Gln Gly  Arg Asn Asp 
    1490                 1495                 1500             


Met Thr  Tyr Asn Tyr Ala Asn  Arg Gln Ser Thr Gly  Ser Ala Pro 
    1505                 1510                 1515             


Gln Gly  Pro Ala Tyr His Gly  Val Asn Arg Thr Asp  Glu Met Leu 
    1520                 1525                 1530             


His Thr  Asp Gln Arg Ala Asn  His Glu Gly Ser Trp  Pro Ser His 
    1535                 1540                 1545             


Gly Thr  Arg Gln Pro Pro Tyr  Gly Pro Ser Ala Pro  Val Pro Pro 
    1550                 1555                 1560             


Met Thr  Arg Pro Pro Pro Ser  Asn Tyr Gln Pro Pro  Pro Ser Met 
    1565                 1570                 1575             


Gln Asn  His Ile Pro Gln Val  Ser Ser Pro Ala Pro  Leu Pro Arg 
    1580                 1585                 1590             


Pro Met  Glu Asn Arg Thr Ser  Pro Ser Lys Ser Pro  Phe Leu His 
    1595                 1600                 1605             


Ser Gly  Met Lys Met Gln Lys  Ala Gly Pro Pro Val  Pro Ala Ser 
    1610                 1615                 1620             


His Ile  Ala Pro Ala Pro Val  Gln Pro Pro Met Ile  Arg Arg Asp 
    1625                 1630                 1635             


Ile Thr  Phe Pro Pro Gly Ser  Val Glu Ala Thr Gln  Pro Val Leu 
    1640                 1645                 1650             


Lys Gln  Arg Arg Arg Leu Thr  Met Lys Asp Ile Gly  Thr Pro Glu 
    1655                 1660                 1665             


Ala Trp  Arg Val Met Met Ser  Leu Lys Ser Gly Leu  Leu Ala Glu 
    1670                 1675                 1680             


Ser Thr  Trp Ala Leu Asp Thr  Ile Asn Ile Leu Leu  Tyr Asp Asp 
    1685                 1690                 1695             


Asn Ser  Ile Met Thr Phe Asn  Leu Ser Gln Leu Pro  Gly Leu Leu 
    1700                 1705                 1710             


Glu Leu  Leu Val Glu Tyr Phe  Arg Arg Cys Leu Ile  Glu Ile Phe 
    1715                 1720                 1725             


Gly Ile  Leu Lys Glu Tyr Glu  Val Gly Asp Pro Gly  Gln Arg Thr 
    1730                 1735                 1740             


Leu Leu  Asp Pro Gly Arg Phe  Ser Lys Val Ser Ser  Pro Ala Pro 
    1745                 1750                 1755             


Met Glu  Gly Gly Glu Glu Glu  Glu Glu Leu Leu Gly  Pro Lys Leu 
    1760                 1765                 1770             


Glu Glu  Glu Glu Glu Glu Glu  Val Val Glu Asn Asp  Glu Glu Ile 
    1775                 1780                 1785             


Ala Phe  Ser Gly Lys Asp Lys  Pro Ala Ser Glu Asn  Ser Glu Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ser Lys Phe Asp  Lys Leu Pro Val Lys  Ile Val Gln 
    1805                 1810                 1815             


Lys Asn  Asp Pro Phe Val Val  Asp Cys Ser Asp Lys  Leu Gly Arg 
    1820                 1825                 1830             


Val Gln  Glu Phe Asp Ser Gly  Leu Leu His Trp Arg  Ile Gly Gly 
    1835                 1840                 1845             


Gly Asp  Thr Thr Glu His Ile  Gln Thr His Phe Glu  Ser Lys Thr 
    1850                 1855                 1860             


Glu Leu  Leu Pro Ser Arg Pro  His Ala Pro Cys Pro  Pro Ala Pro 
    1865                 1870                 1875             


Arg Lys  His Val Thr Thr Ala  Glu Gly Thr Pro Gly  Thr Thr Asp 
    1880                 1885                 1890             


Gln Glu  Gly Pro Pro Pro Asp  Gly Pro Pro Glu Lys  Arg Ile Thr 
    1895                 1900                 1905             


Ala Thr  Met Asp Asp Met Leu  Ser Thr Arg Ser Ser  Thr Leu Thr 
    1910                 1915                 1920             


Glu Asp  Gly Ala Lys Ser Ser  Glu Ala Ile Lys Glu  Ser Ser Lys 
    1925                 1930                 1935             


Phe Pro  Phe Gly Ile Ser Pro  Ala Gln Ser His Arg  Asn Ile Lys 
    1940                 1945                 1950             


Ile Leu  Glu Asp Glu Pro His  Ser Lys Asp Glu Thr  Pro Leu Cys 
    1955                 1960                 1965             


Thr Leu  Leu Asp Trp Gln Asp  Ser Leu Ala Lys Arg  Cys Val Cys 
    1970                 1975                 1980             


Val Ser  Asn Thr Ile Arg Ser  Leu Ser Phe Val Pro  Gly Asn Asp 
    1985                 1990                 1995             


Phe Glu  Met Ser Lys His Pro  Gly Leu Leu Leu Ile  Leu Gly Lys 
    2000                 2005                 2010             


Leu Ile  Leu Leu His His Lys  His Pro Glu Arg Lys  Gln Ala Pro 
    2015                 2020                 2025             


Leu Thr  Tyr Glu Lys Glu Glu  Glu Gln Asp Gln Gly  Val Ser Cys 
    2030                 2035                 2040             


Asn Lys  Val Glu Trp Trp Trp  Asp Cys Leu Glu Met  Leu Arg Glu 
    2045                 2050                 2055             


Asn Thr  Leu Val Thr Leu Ala  Asn Ile Ser Gly Gln  Leu Asp Leu 
    2060                 2065                 2070             


Ser Pro  Tyr Pro Glu Ser Ile  Cys Leu Pro Val Leu  Asp Gly Leu 
    2075                 2080                 2085             


Leu His  Trp Ala Val Cys Pro  Ser Ala Glu Ala Gln  Asp Pro Phe 
    2090                 2095                 2100             


Ser Thr  Leu Gly Pro Asn Ala  Val Leu Ser Pro Gln  Arg Leu Val 
    2105                 2110                 2115             


Leu Glu  Thr Leu Ser Lys Leu  Ser Ile Gln Asp Asn  Asn Val Asp 
    2120                 2125                 2130             


Leu Ile  Leu Ala Thr Pro Pro  Phe Ser Arg Leu Glu  Lys Leu Tyr 
    2135                 2140                 2145             


Ser Thr  Met Val Arg Phe Leu  Ser Asp Arg Lys Asn  Pro Val Cys 
    2150                 2155                 2160             


Arg Glu  Met Ala Val Val Leu  Leu Ala Asn Leu Ala  Gln Gly Asp 
    2165                 2170                 2175             


Ser Leu  Ala Ala Arg Ala Ile  Ala Val Gln Lys Gly  Ser Ile Gly 
    2180                 2185                 2190             


Asn Leu  Leu Gly Phe Leu Glu  Asp Ser Leu Ala Ala  Thr Gln Phe 
    2195                 2200                 2205             


Gln Gln  Ser Gln Ala Ser Leu  Leu His Met Gln Asn  Pro Pro Phe 
    2210                 2215                 2220             


Glu Pro  Thr Ser Val Asp Met  Met Arg Arg Ala Ala  Arg Ala Leu 
    2225                 2230                 2235             


Leu Ala  Leu Ala Lys Val Asp  Glu Asn His Ser Glu  Phe Thr Leu 
    2240                 2245                 2250             


Tyr Glu  Ser Arg Leu Leu Asp  Ile Ser Val Ser Pro  Leu Met Asn 
    2255                 2260                 2265             


Ser Leu  Val Ser Gln Val Ile  Cys Asp Val Leu Phe  Leu Ile Gly 
    2270                 2275                 2280             


Gln Ser  
    2285 


<210>  10
<211>  8585
<212>  DNA
<213>  Homo sapiens

<400>  10
cagaaagcgg agagtcacag cggggccagg ccctggggag cggagcctcc accgcccccc       60

tcattcccag gcaagggctt ggggggaatg agccgggaga gccgggtccc gagcctacag      120

agccgggagc agctgagccg ccggcgcctc ggccgccgcc gccgcctcct cctcctccgc      180

cgccgccagc ccggagcctg agccggcggg gcggggggga gaggagcgag cgcagcgcag      240

cagcggagcc ccgcgaggcc cgcccgggcg ggtggggagg gcagcccggg ggactgggcc      300

ccggggcggg gtgggagggg gggagaagac gaagacaggg ccgggtctct ccgcggacga      360

gacagcgggg atcatggccg cgcaggtcgc ccccgccgcc gccagcagcc tgggcaaccc      420

gccgccgccg ccgccctcgg agctgaagaa agccgagcag cagcagcggg aggaggcggg      480

gggcgaggcg gcggcggcgg cagcggccga gcgcggggaa atgaaggcag ccgccgggca      540

ggaaagcgag ggccccgccg tggggccgcc gcagccgctg ggaaaggagc tgcaggacgg      600

ggccgagagc aatgggggtg gcggcggcgg cggagccggc agcggcggcg ggcccggcgc      660

ggagccggac ctgaagaact cgaacgggaa cgcgggccct aggcccgccc tgaacaataa      720

cctcacggag ccgcccggcg gcggcggtgg cggcagcagc gatggggtgg gggcgcctcc      780

tcactcagcc gcggccgcct tgccgccccc agcctacggc ttcgggcaac cctacggccg      840

gagcccgtct gccgtcgccg ccgccgcggc cgccgtcttc caccaacaac atggcggaca      900

acaaagccct ggcctggcag cgctgcagag cggcggcggc gggggcctgg agccctacgc      960

ggggccccag cagaactctc acgaccacgg cttccccaac caccagtaca actcctacta     1020

ccccaaccgc agcgcctacc ccccgcccgc cccggcctac gcgctgagct ccccgagagg     1080

tggcactccg ggctccggcg cggcggcggc tgccggctcc aagccgcctc cctcctccag     1140

cgcctccgcc tcctcgtcgt cttcgtcctt cgctcagcag cgcttcgggg ccatgggggg     1200

aggcggcccc tccgcggccg gcgggggaac tccccagccc accgccaccc ccaccctcaa     1260

ccaactgctc acgtcgccca gctcggcccg gggctaccag ggctaccccg ggggcgacta     1320

cagtggcggg ccccaggacg ggggcgccgg caagggcccg gcggacatgg cctcgcagtg     1380

ttggggggct gcggcggcgg cagctgcggc ggcggccgcc tcgggagggg cccaacaaag     1440

gagccaccac gcgcccatga gccccgggag cagcggcggc ggggggcagc cgctcgcccg     1500

gacccctcag ccatccagtc caatggatca gatgggcaag atgagacctc agccatatgg     1560

cgggactaac ccatactcgc agcaacaggg acctccgtca ggaccgcagc aaggacatgg     1620

gtacccaggg cagccatacg ggtcccagac cccgcagcgg tacccgatga ccatgcaggg     1680

ccgggcgcag agtgccatgg gcggcctctc ttatacacag cagattcctc cttatggaca     1740

acaaggcccc agcgggtatg gtcaacaggg ccagactcca tattacaacc agcaaagtcc     1800

tcaccctcag cagcagcagc caccctactc ccagcaacca ccgtcccaga cccctcatgc     1860

ccaaccttcg tatcagcagc agccacagtc tcaaccacca cagctccagt cctctcagcc     1920

tccatactcc cagcagccat cccagcctcc acatcagcag tccccggctc catacccctc     1980

ccagcagtcg acgacacagc agcaccccca gagccagccc ccctactcac agccacaggc     2040

tcagtctcct taccagcagc agcaacctca gcagccagca ccctcgacgc tctcccagca     2100

ggctgcgtat cctcagcccc agtctcagca gtcccagcaa actgcctatt cccagcagcg     2160

cttccctcca ccgcaggagc tatctcaaga ttcatttggg tctcaggcat cctcagcccc     2220

ctcaatgacc tccagtaagg gagggcaaga agatatgaac ctgagccttc agtcaagacc     2280

ctccagcttg cctgatctat ctggttcaat agatgacctc cccatgggga cagaaggagc     2340

tctgagtcct ggagtgagca catcagggat ttccagcagc caaggagagc agagtaatcc     2400

agctcagtct cctttctctc ctcatacctc ccctcacctg cctggcatcc gaggcccttc     2460

cccgtcccct gttggctctc ccgccagtgt tgctcagtct cgctcaggac cactctcgcc     2520

tgctgcagtg ccaggcaacc agatgccacc tcggccaccc agtggccagt cggacagcat     2580

catgcatcct tccatgaacc aatcaagcat tgcccaagat cgaggttata tgcagaggaa     2640

cccccagatg ccccagtaca gttcccccca gcccggctca gccttatctc cgcgtcagcc     2700

ttccggagga cagatacaca caggcatggg ctcctaccag cagaactcca tggggagcta     2760

tggtccccag gggggtcagt atggcccaca aggtggctac cccaggcagc caaactataa     2820

tgccttgccc aatgccaact accccagtgc aggcatggct ggaggcataa accccatggg     2880

tgccggaggt caaatgcatg gacagcctgg catcccacct tatggcacac tccctccagg     2940

gaggatgagt cacgcctcca tgggcaaccg gccttatggc cctaacatgg ccaatatgcc     3000

acctcaggtt gggtcaggga tgtgtccccc accagggggc atgaaccgga aaacccaaga     3060

aactgctgtc gccatgcatg ttgctgccaa ctctatccaa aacaggccgc caggctaccc     3120

caatatgaat caagggggca tgatgggaac tggacctcct tatggacaag ggattaatag     3180

tatggctggc atgatcaacc ctcagggacc cccatattcc atgggtggaa ccatggccaa     3240

caattctgca gggatggcag ccagcccaga gatgatgggc cttggggatg taaagttaac     3300

tccagccacc aaaatgaaca acaaggcaga tgggacaccc aagacagaat ccaaatccaa     3360

gaaatccagt tcttctacta caaccaatga gaagatcacc aagttgtatg agctgggtgg     3420

tgagcctgag aggaagatgt gggtggaccg ttatctggcc ttcactgagg agaaggccat     3480

gggcatgaca aatctgcctg ctgtgggtag gaaacctctg gacctctatc gcctctatgt     3540

gtctgtgaag gagattggtg gattgactca ggtcaacaag aacaaaaaat ggcgggaact     3600

tgcaaccaac ctcaatgtgg gcacatcaag cagtgctgcc agctccttga aaaagcagta     3660

tatccagtgt ctctatgcct ttgaatgcaa gattgaacgg ggagaagacc ctcccccaga     3720

catctttgca gctgctgatt ccaagaagtc ccagcccaag atccagcctc cctctcctgc     3780

gggatcagga tctatgcagg ggccccagac tccccagtca accagcagtt ccatggcaga     3840

aggaggagac ttaaagccac caactccagc atccacacca cacagtcaga tccccccatt     3900

gccaggcatg agcaggagca attcagttgg gatccaggat gcctttaatg atggaagtga     3960

ctccacattc cagaagcgga attccatgac tccaaaccct gggtatcagc ccagtatgaa     4020

tacctctgac atgatggggc gcatgtccta tgagccaaat aaggatcctt atggcagcat     4080

gaggaaagct ccagggagtg atcccttcat gtcctcaggg cagggcccca acggcgggat     4140

gggtgacccc tacagtcgtg ctgccggccc tgggctagga aatgtggcga tgggaccacg     4200

acagcactat ccctatggag gtccttatga cagagtgagg acggagcctg gaatagggcc     4260

tgagggaaac atgagcactg gggccccaca gccgaatctc atgccttcca acccagactc     4320

ggggatgtat tctcctagcc gctacccccc gcagcagcag cagcagcagc agcaacgaca     4380

tgattcctat ggcaatcagt tctccaccca aggcacccct tctggcagcc ccttccccag     4440

ccagcagact acaatgtatc aacagcaaca gcagaattac aagcggccaa tggatggcac     4500

atatggccct cctgccaagc ggcacgaagg ggagatgtac agcgtgccat acagcactgg     4560

gcaggggcag cctcagcagc agcagttgcc cccagcccag ccccagcctg ccagccagca     4620

acaagctgcc cagccttccc ctcagcaaga tgtatacaac cagtatggca atgcctatcc     4680

tgccactgcc acagctgcta ctgagcgccg accagcaggc ggcccccaga accaatttcc     4740

attccagttt ggccgagacc gtgtctctgc accccctggc accaatgccc agcaaaacat     4800

gccaccacaa atgatgggcg gccccataca ggcatcagct gaggttgctc agcaaggcac     4860

catgtggcag gggcgtaatg acatgaccta taattatgcc aacaggcaga gcacgggctc     4920

tgccccccag ggccccgcct atcatggcgt gaaccgaaca gatgaaatgc tgcacacaga     4980

tcagagggcc aaccacgaag gctcgtggcc ttcccatggc acacgccagc ccccatatgg     5040

tccctctgcc cctgtgcccc ccatgacaag gccccctcca tctaactacc agcccccacc     5100

aagcatgcag aatcacattc ctcaggtatc cagccctgct cccctgcccc ggccaatgga     5160

gaaccgcacc tctcctagca agtctccatt cctgcactct gggatgaaaa tgcagaaggc     5220

aggtccccca gtacctgcct cgcacatagc acctgcccct gtgcagcccc ccatgattcg     5280

gcgggatatc accttcccac ctggctctgt tgaagccaca cagcctgtgt tgaagcagag     5340

gaggcggctc acaatgaaag acattggaac cccggaggca tggcgggtaa tgatgtccct     5400

caagtctggt ctcctggcag agagcacatg ggcattagat accatcaaca tcctgctgta     5460

tgatgacaac agcatcatga ccttcaacct cagtcagctc ccagggttgc tagagctcct     5520

tgtagaatat ttccgacgat gcctgattga gatctttggc attttaaagg agtatgaggt     5580

gggtgaccca ggacagagaa cgctactgga tcctgggagg ttcagcaagg tgtctagtcc     5640

agctcccatg gagggtgggg aagaagaaga agaacttcta ggtcctaaac tagaagagga     5700

agaagaagag gaagtagttg aaaatgatga ggagatagcc ttttcaggca aggacaagcc     5760

agcttcagag aatagtgagg agaagctgat cagtaagttt gacaagcttc cagtaaagat     5820

cgtacagaag aatgatccat ttgtggtgga ctgctcagat aagcttgggc gtgtgcagga     5880

gtttgacagt ggcctgctgc actggcggat tggtgggggg gacaccactg agcatatcca     5940

gacccacttc gagagcaaga cagagctgct gccttcccgg cctcacgcac cctgcccacc     6000

agcccctcgg aagcatgtga caacagcaga gggtacacca gggacaacag accaggaggg     6060

gcccccacct gatggacctc cagaaaaacg gatcacagcc actatggatg acatgttgtc     6120

tactcggtct agcaccttga ccgaggatgg agctaagagt tcagaggcca tcaaggagag     6180

cagcaagttt ccatttggca ttagcccagc acagagccac cggaacatca agatcctaga     6240

ggacgaaccc cacagtaagg atgagacccc actgtgtacc cttctggact ggcaggattc     6300

tcttgccaag cgctgcgtct gtgtgtccaa taccattcga agcctgtcat ttgtgccagg     6360

caatgacttt gagatgtcca aacacccagg gctgctgctc atcctgggca agctgatcct     6420

gctgcaccac aagcacccag aacggaagca ggcaccacta acttatgaaa aggaggagga     6480

acaggaccaa ggggtgagct gcaacaaagt ggagtggtgg tgggactgct tggagatgct     6540

ccgggaaaac accttggtta cactcgccaa catctcgggg cagttggacc tatctccata     6600

ccccgagagc atttgcctgc ctgtcctgga cggactccta cactgggcag tttgcccttc     6660

agctgaagcc caggacccct tttccaccct gggccccaat gccgtccttt ccccgcagag     6720

actggtcttg gaaaccctca gcaaactcag catccaggac aacaatgtgg acctgattct     6780

ggccacaccc cccttcagcc gcctggagaa gttgtatagc actatggtgc gcttcctcag     6840

tgaccgaaag aacccggtgt gccgggagat ggctgtggta ctgctggcca acctggctca     6900

gggggacagc ctggcagctc gtgccattgc agtgcagaag ggcagtatcg gcaacctcct     6960

gggcttccta gaggacagcc ttgccgccac acagttccag cagagccagg ccagcctcct     7020

ccacatgcag aacccaccct ttgagccaac tagtgtggac atgatgcggc gggctgcccg     7080

cgcgctgctt gccttggcca aggtggacga gaaccactca gagtttactc tgtacgaatc     7140

acggctgttg gacatctcgg tatcaccgtt gatgaactca ttggtttcac aagtcatttg     7200

tgatgtactg tttttgattg gccagtcatg acagccgtgg gacacctccc ccccccgtgt     7260

gtgtgtgcgt gtgtggagaa cttagaaact gactgttgcc ctttatttat gcaaaaccac     7320

ctcagaatcc agtttaccct gtgctgtcca gcttctccct tgggaaaaag tctctcctgt     7380

ttctctctcc tccttccacc tcccctccct ccatcacctc acgcctttct gttccttgtc     7440

ctcaccttac tcccctcagg accctacccc accctctttg aaaagacaaa gctctgccta     7500

catagaagac tttttttatt ttaaccaaag ttactgttgt ttacagtgag tttggggaaa     7560

aaaaataaaa taaaaatggc tttcccagtc cttgcatcaa cgggatgcca catttcataa     7620

ctgtttttaa tggtaaaaaa aaaaaaaaaa aatacaaaaa aaaattctga aggacaaaaa     7680

aggtgactgc tgaactgtgt gtggtttatt gttgtacatt cacaatcttg caggagccaa     7740

gaagttcgca gttgtgaaca gaccctgttc actggagagg cctgtgcagt agagtgtaga     7800

ccctttcatg tactgtactg tacacctgat actgtaaaca tactgtaata ataatgtctc     7860

acatggaaac agaaaacgct gggtcagcag caagctgtag tttttaaaaa tgtttttagt     7920

taaacgttga ggagaaaaaa aaaaaaggct tttcccccaa agtatcatgt gtgaacctac     7980

aacaccctga cctctttctc tcctccttga ttgtatgaat aaccctgaga tcacctctta     8040

gaactggttt taacctttag ctgcagcggc tacgctgcca cgtgtgtata tatatgacgt     8100

tgtacattgc acataccctt ggatccccac agtttggtcc tcctcccagc taccccttta     8160

tagtatgacg agttaacaag ttggtgacct gcacaaagcg agacacagct atttaatctc     8220

ttgccagata tcgcccctct tggtgcgatg ctgtacaggt ctctgtaaaa agtccttgct     8280

gtctcagcag ccaatcaact tatagtttat ttttttctgg gtttttgttt tgttttgttt     8340

tctttctaat cgaggtgtga aaaagttcta ggttcagttg aagttctgat gaagaaacac     8400

aattgagatt ttttcagtga taaaatctgc atatttgtat ttcaacaatg tagctaaaac     8460

ttgatgtaaa ttcctccttt ttttcctttt ttggcttaat gaatatcatt tattcagtat     8520

gaaatcttta tactatatgt tccacgtgtt aagaataaat gtacattaaa tcttggtaag     8580

acttt                                                                 8585


<210>  11
<211>  2068
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg 
            20                  25                  30          


Glu Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly 
        35                  40                  45              


Glu Met Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly 
    50                  55                  60                  


Pro Pro Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala 
                85                  90                  95      


Glu Pro Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala 
            100                 105                 110         


Leu Asn Asn Asn Leu Thr Glu Pro Pro Gly Gly Gly Gly Gly Gly Ser 
        115                 120                 125             


Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu Pro 
    130                 135                 140                 


Pro Pro Ala Tyr Gly Phe Gly Gln Pro Tyr Gly Arg Ser Pro Ser Ala 
145                 150                 155                 160 


Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly Gln 
                165                 170                 175     


Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly Leu 
            180                 185                 190         


Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe Pro 
        195                 200                 205             


Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro Pro 
    210                 215                 220                 


Pro Ala Pro Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Thr Pro Gly 
225                 230                 235                 240 


Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser Ser 
                245                 250                 255     


Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe Gly 
            260                 265                 270         


Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Thr Pro Gln 
        275                 280                 285             


Pro Thr Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Ser 
    290                 295                 300                 


Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Ser Gly Gly Pro 
305                 310                 315                 320 


Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln Cys 
                325                 330                 335     


Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly 
            340                 345                 350         


Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser Ser Gly 
        355                 360                 365             


Gly Gly Gly Gln Pro Leu Ala Arg Thr Pro Gln Pro Ser Ser Pro Met 
    370                 375                 380                 


Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Thr Asn Pro 
385                 390                 395                 400 


Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His Gly 
                405                 410                 415     


Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Thr Pro Gln Arg Tyr Pro Met 
            420                 425                 430         


Thr Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr Thr 
        435                 440                 445             


Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly Gln 
    450                 455                 460                 


Gln Gly Gln Thr Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln Gln 
465                 470                 475                 480 


Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Thr Pro His Ala 
                485                 490                 495     


Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu Gln 
            500                 505                 510         


Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His Gln 
        515                 520                 525             


Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Thr Thr Gln Gln His 
    530                 535                 540                 


Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro Tyr 
545                 550                 555                 560 


Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Thr Leu Ser Gln Gln 
                565                 570                 575     


Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Thr Ala Tyr 
            580                 585                 590         


Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser Phe 
        595                 600                 605             


Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Thr Ser Ser Lys Gly Gly 
    610                 615                 620                 


Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu Pro 
625                 630                 635                 640 


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Thr Glu Gly Ala 
                645                 650                 655     


Leu Ser Pro Gly Val Ser Thr Ser Gly Ile Ser Ser Ser Gln Gly Glu 
            660                 665                 670         


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Thr Ser Pro His 
        675                 680                 685             


Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala 
    690                 695                 700                 


Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro 
705                 710                 715                 720 


Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser Ile 
                725                 730                 735     


Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr 
            740                 745                 750         


Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly 
        755                 760                 765             


Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Thr Gly 
    770                 775                 780                 


Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly 
785                 790                 795                 800 


Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn 
                805                 810                 815     


Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile 
            820                 825                 830         


Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro 
        835                 840                 845             


Pro Tyr Gly Thr Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly 
    850                 855                 860                 


Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val Gly 
865                 870                 875                 880 


Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Thr Gln Glu 
                885                 890                 895     


Thr Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro 
            900                 905                 910         


Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Thr Gly Pro 
        915                 920                 925             


Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln 
    930                 935                 940                 


Gly Pro Pro Tyr Ser Met Gly Gly Thr Met Ala Asn Asn Ser Ala Gly 
945                 950                 955                 960 


Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Thr 
                965                 970                 975     


Pro Ala Thr Lys Met Asn Asn Lys Ala Asp Gly Thr Pro Lys Thr Glu 
            980                 985                 990         


Ser Lys Ser Lys Lys Ser Ser Ser  Ser Thr Thr Thr Asn  Glu Lys Ile 
        995                 1000                 1005             


Thr Lys  Leu Tyr Glu Leu Gly  Gly Glu Pro Glu Arg  Lys Met Trp 
    1010                 1015                 1020             


Val Asp  Arg Tyr Leu Ala Phe  Thr Glu Glu Lys Ala  Met Gly Met 
    1025                 1030                 1035             


Thr Asn  Leu Pro Ala Val Gly  Arg Lys Pro Leu Asp  Leu Tyr Arg 
    1040                 1045                 1050             


Leu Tyr  Val Ser Val Lys Glu  Ile Gly Gly Leu Thr  Gln Val Asn 
    1055                 1060                 1065             


Lys Asn  Lys Lys Trp Arg Glu  Leu Ala Thr Asn Leu  Asn Val Gly 
    1070                 1075                 1080             


Thr Ser  Ser Ser Ala Ala Ser  Ser Leu Lys Lys Gln  Tyr Ile Gln 
    1085                 1090                 1095             


Cys Leu  Tyr Ala Phe Glu Cys  Lys Ile Glu Arg Gly  Glu Asp Pro 
    1100                 1105                 1110             


Pro Pro  Asp Ile Phe Ala Ala  Ala Asp Ser Lys Lys  Ser Gln Pro 
    1115                 1120                 1125             


Lys Ile  Gln Pro Pro Ser Pro  Ala Gly Ser Gly Ser  Met Gln Gly 
    1130                 1135                 1140             


Pro Gln  Thr Pro Gln Ser Thr  Ser Ser Ser Met Ala  Glu Gly Gly 
    1145                 1150                 1155             


Asp Leu  Lys Pro Pro Thr Pro  Ala Ser Thr Pro His  Ser Gln Ile 
    1160                 1165                 1170             


Pro Pro  Leu Pro Gly Met Ser  Arg Ser Asn Ser Val  Gly Ile Gln 
    1175                 1180                 1185             


Asp Ala  Phe Asn Asp Gly Ser  Asp Ser Thr Phe Gln  Lys Arg Asn 
    1190                 1195                 1200             


Ser Met  Thr Pro Asn Pro Gly  Tyr Gln Pro Ser Met  Asn Thr Ser 
    1205                 1210                 1215             


Asp Met  Met Gly Arg Met Ser  Tyr Glu Pro Asn Lys  Asp Pro Tyr 
    1220                 1225                 1230             


Gly Ser  Met Arg Lys Ala Pro  Gly Ser Asp Pro Phe  Met Ser Ser 
    1235                 1240                 1245             


Gly Gln  Gly Pro Asn Gly Gly  Met Gly Asp Pro Tyr  Ser Arg Ala 
    1250                 1255                 1260             


Ala Gly  Pro Gly Leu Gly Asn  Val Ala Met Gly Pro  Arg Gln His 
    1265                 1270                 1275             


Tyr Pro  Tyr Gly Gly Pro Tyr  Asp Arg Val Arg Thr  Glu Pro Gly 
    1280                 1285                 1290             


Ile Gly  Pro Glu Gly Asn Met  Ser Thr Gly Ala Pro  Gln Pro Asn 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Pro Asp  Ser Gly Met Tyr Ser  Pro Ser Arg 
    1310                 1315                 1320             


Tyr Pro  Pro Gln Gln Gln Gln  Gln Gln Gln Gln Arg  His Asp Ser 
    1325                 1330                 1335             


Tyr Gly  Asn Gln Phe Ser Thr  Gln Gly Thr Pro Ser  Gly Ser Pro 
    1340                 1345                 1350             


Phe Pro  Ser Gln Gln Thr Thr  Met Tyr Gln Gln Gln  Gln Gln Val 
    1355                 1360                 1365             


Ser Ser  Pro Ala Pro Leu Pro  Arg Pro Met Glu Asn  Arg Thr Ser 
    1370                 1375                 1380             


Pro Ser  Lys Ser Pro Phe Leu  His Ser Gly Met Lys  Met Gln Lys 
    1385                 1390                 1395             


Ala Gly  Pro Pro Val Pro Ala  Ser His Ile Ala Pro  Ala Pro Val 
    1400                 1405                 1410             


Gln Pro  Pro Met Ile Arg Arg  Asp Ile Thr Phe Pro  Pro Gly Ser 
    1415                 1420                 1425             


Val Glu  Ala Thr Gln Pro Val  Leu Lys Gln Arg Arg  Arg Leu Thr 
    1430                 1435                 1440             


Met Lys  Asp Ile Gly Thr Pro  Glu Ala Trp Arg Val  Met Met Ser 
    1445                 1450                 1455             


Leu Lys  Ser Gly Leu Leu Ala  Glu Ser Thr Trp Ala  Leu Asp Thr 
    1460                 1465                 1470             


Ile Asn  Ile Leu Leu Tyr Asp  Asp Asn Ser Ile Met  Thr Phe Asn 
    1475                 1480                 1485             


Leu Ser  Gln Leu Pro Gly Leu  Leu Glu Leu Leu Val  Glu Tyr Phe 
    1490                 1495                 1500             


Arg Arg  Cys Leu Ile Glu Ile  Phe Gly Ile Leu Lys  Glu Tyr Glu 
    1505                 1510                 1515             


Val Gly  Asp Pro Gly Gln Arg  Thr Leu Leu Asp Pro  Gly Arg Phe 
    1520                 1525                 1530             


Ser Lys  Val Ser Ser Pro Ala  Pro Met Glu Gly Gly  Glu Glu Glu 
    1535                 1540                 1545             


Glu Glu  Leu Leu Gly Pro Lys  Leu Glu Glu Glu Glu  Glu Glu Glu 
    1550                 1555                 1560             


Val Val  Glu Asn Asp Glu Glu  Ile Ala Phe Ser Gly  Lys Asp Lys 
    1565                 1570                 1575             


Pro Ala  Ser Glu Asn Ser Glu  Glu Lys Leu Ile Ser  Lys Phe Asp 
    1580                 1585                 1590             


Lys Leu  Pro Val Lys Ile Val  Gln Lys Asn Asp Pro  Phe Val Val 
    1595                 1600                 1605             


Asp Cys  Ser Asp Lys Leu Gly  Arg Val Gln Glu Phe  Asp Ser Gly 
    1610                 1615                 1620             


Leu Leu  His Trp Arg Ile Gly  Gly Gly Asp Thr Thr  Glu His Ile 
    1625                 1630                 1635             


Gln Thr  His Phe Glu Ser Lys  Thr Glu Leu Leu Pro  Ser Arg Pro 
    1640                 1645                 1650             


His Ala  Pro Cys Pro Pro Ala  Pro Arg Lys His Val  Thr Thr Ala 
    1655                 1660                 1665             


Glu Gly  Thr Pro Gly Thr Thr  Asp Gln Glu Gly Pro  Pro Pro Asp 
    1670                 1675                 1680             


Gly Pro  Pro Glu Lys Arg Ile  Thr Ala Thr Met Asp  Asp Met Leu 
    1685                 1690                 1695             


Ser Thr  Arg Ser Ser Thr Leu  Thr Glu Asp Gly Ala  Lys Ser Ser 
    1700                 1705                 1710             


Glu Ala  Ile Lys Glu Ser Ser  Lys Phe Pro Phe Gly  Ile Ser Pro 
    1715                 1720                 1725             


Ala Gln  Ser His Arg Asn Ile  Lys Ile Leu Glu Asp  Glu Pro His 
    1730                 1735                 1740             


Ser Lys  Asp Glu Thr Pro Leu  Cys Thr Leu Leu Asp  Trp Gln Asp 
    1745                 1750                 1755             


Ser Leu  Ala Lys Arg Cys Val  Cys Val Ser Asn Thr  Ile Arg Ser 
    1760                 1765                 1770             


Leu Ser  Phe Val Pro Gly Asn  Asp Phe Glu Met Ser  Lys His Pro 
    1775                 1780                 1785             


Gly Leu  Leu Leu Ile Leu Gly  Lys Leu Ile Leu Leu  His His Lys 
    1790                 1795                 1800             


His Pro  Glu Arg Lys Gln Ala  Pro Leu Thr Tyr Glu  Lys Glu Glu 
    1805                 1810                 1815             


Glu Gln  Asp Gln Gly Val Ser  Cys Asn Lys Val Glu  Trp Trp Trp 
    1820                 1825                 1830             


Asp Cys  Leu Glu Met Leu Arg  Glu Asn Thr Leu Val  Thr Leu Ala 
    1835                 1840                 1845             


Asn Ile  Ser Gly Gln Leu Asp  Leu Ser Pro Tyr Pro  Glu Ser Ile 
    1850                 1855                 1860             


Cys Leu  Pro Val Leu Asp Gly  Leu Leu His Trp Ala  Val Cys Pro 
    1865                 1870                 1875             


Ser Ala  Glu Ala Gln Asp Pro  Phe Ser Thr Leu Gly  Pro Asn Ala 
    1880                 1885                 1890             


Val Leu  Ser Pro Gln Arg Leu  Val Leu Glu Thr Leu  Ser Lys Leu 
    1895                 1900                 1905             


Ser Ile  Gln Asp Asn Asn Val  Asp Leu Ile Leu Ala  Thr Pro Pro 
    1910                 1915                 1920             


Phe Ser  Arg Leu Glu Lys Leu  Tyr Ser Thr Met Val  Arg Phe Leu 
    1925                 1930                 1935             


Ser Asp  Arg Lys Asn Pro Val  Cys Arg Glu Met Ala  Val Val Leu 
    1940                 1945                 1950             


Leu Ala  Asn Leu Ala Gln Gly  Asp Ser Leu Ala Ala  Arg Ala Ile 
    1955                 1960                 1965             


Ala Val  Gln Lys Gly Ser Ile  Gly Asn Leu Leu Gly  Phe Leu Glu 
    1970                 1975                 1980             


Asp Ser  Leu Ala Ala Thr Gln  Phe Gln Gln Ser Gln  Ala Ser Leu 
    1985                 1990                 1995             


Leu His  Met Gln Asn Pro Pro  Phe Glu Pro Thr Ser  Val Asp Met 
    2000                 2005                 2010             


Met Arg  Arg Ala Ala Arg Ala  Leu Leu Ala Leu Ala  Lys Val Asp 
    2015                 2020                 2025             


Glu Asn  His Ser Glu Phe Thr  Leu Tyr Glu Ser Arg  Leu Leu Asp 
    2030                 2035                 2040             


Ile Ser  Val Ser Pro Leu Met  Asn Ser Leu Val Ser  Gln Val Ile 
    2045                 2050                 2055             


Cys Asp  Val Leu Phe Leu Ile  Gly Gln Ser 
    2060                 2065             


<210>  12
<211>  7934
<212>  DNA
<213>  Homo sapiens

<400>  12
cagaaagcgg agagtcacag cggggccagg ccctggggag cggagcctcc accgcccccc       60

tcattcccag gcaagggctt ggggggaatg agccgggaga gccgggtccc gagcctacag      120

agccgggagc agctgagccg ccggcgcctc ggccgccgcc gccgcctcct cctcctccgc      180

cgccgccagc ccggagcctg agccggcggg gcggggggga gaggagcgag cgcagcgcag      240

cagcggagcc ccgcgaggcc cgcccgggcg ggtggggagg gcagcccggg ggactgggcc      300

ccggggcggg gtgggagggg gggagaagac gaagacaggg ccgggtctct ccgcggacga      360

gacagcgggg atcatggccg cgcaggtcgc ccccgccgcc gccagcagcc tgggcaaccc      420

gccgccgccg ccgccctcgg agctgaagaa agccgagcag cagcagcggg aggaggcggg      480

gggcgaggcg gcggcggcgg cagcggccga gcgcggggaa atgaaggcag ccgccgggca      540

ggaaagcgag ggccccgccg tggggccgcc gcagccgctg ggaaaggagc tgcaggacgg      600

ggccgagagc aatgggggtg gcggcggcgg cggagccggc agcggcggcg ggcccggcgc      660

ggagccggac ctgaagaact cgaacgggaa cgcgggccct aggcccgccc tgaacaataa      720

cctcacggag ccgcccggcg gcggcggtgg cggcagcagc gatggggtgg gggcgcctcc      780

tcactcagcc gcggccgcct tgccgccccc agcctacggc ttcgggcaac cctacggccg      840

gagcccgtct gccgtcgccg ccgccgcggc cgccgtcttc caccaacaac atggcggaca      900

acaaagccct ggcctggcag cgctgcagag cggcggcggc gggggcctgg agccctacgc      960

ggggccccag cagaactctc acgaccacgg cttccccaac caccagtaca actcctacta     1020

ccccaaccgc agcgcctacc ccccgcccgc cccggcctac gcgctgagct ccccgagagg     1080

tggcactccg ggctccggcg cggcggcggc tgccggctcc aagccgcctc cctcctccag     1140

cgcctccgcc tcctcgtcgt cttcgtcctt cgctcagcag cgcttcgggg ccatgggggg     1200

aggcggcccc tccgcggccg gcgggggaac tccccagccc accgccaccc ccaccctcaa     1260

ccaactgctc acgtcgccca gctcggcccg gggctaccag ggctaccccg ggggcgacta     1320

cagtggcggg ccccaggacg ggggcgccgg caagggcccg gcggacatgg cctcgcagtg     1380

ttggggggct gcggcggcgg cagctgcggc ggcggccgcc tcgggagggg cccaacaaag     1440

gagccaccac gcgcccatga gccccgggag cagcggcggc ggggggcagc cgctcgcccg     1500

gacccctcag ccatccagtc caatggatca gatgggcaag atgagacctc agccatatgg     1560

cgggactaac ccatactcgc agcaacaggg acctccgtca ggaccgcagc aaggacatgg     1620

gtacccaggg cagccatacg ggtcccagac cccgcagcgg tacccgatga ccatgcaggg     1680

ccgggcgcag agtgccatgg gcggcctctc ttatacacag cagattcctc cttatggaca     1740

acaaggcccc agcgggtatg gtcaacaggg ccagactcca tattacaacc agcaaagtcc     1800

tcaccctcag cagcagcagc caccctactc ccagcaacca ccgtcccaga cccctcatgc     1860

ccaaccttcg tatcagcagc agccacagtc tcaaccacca cagctccagt cctctcagcc     1920

tccatactcc cagcagccat cccagcctcc acatcagcag tccccggctc catacccctc     1980

ccagcagtcg acgacacagc agcaccccca gagccagccc ccctactcac agccacaggc     2040

tcagtctcct taccagcagc agcaacctca gcagccagca ccctcgacgc tctcccagca     2100

ggctgcgtat cctcagcccc agtctcagca gtcccagcaa actgcctatt cccagcagcg     2160

cttccctcca ccgcaggagc tatctcaaga ttcatttggg tctcaggcat cctcagcccc     2220

ctcaatgacc tccagtaagg gagggcaaga agatatgaac ctgagccttc agtcaagacc     2280

ctccagcttg cctgatctat ctggttcaat agatgacctc cccatgggga cagaaggagc     2340

tctgagtcct ggagtgagca catcagggat ttccagcagc caaggagagc agagtaatcc     2400

agctcagtct cctttctctc ctcatacctc ccctcacctg cctggcatcc gaggcccttc     2460

cccgtcccct gttggctctc ccgccagtgt tgctcagtct cgctcaggac cactctcgcc     2520

tgctgcagtg ccaggcaacc agatgccacc tcggccaccc agtggccagt cggacagcat     2580

catgcatcct tccatgaacc aatcaagcat tgcccaagat cgaggttata tgcagaggaa     2640

cccccagatg ccccagtaca gttcccccca gcccggctca gccttatctc cgcgtcagcc     2700

ttccggagga cagatacaca caggcatggg ctcctaccag cagaactcca tggggagcta     2760

tggtccccag gggggtcagt atggcccaca aggtggctac cccaggcagc caaactataa     2820

tgccttgccc aatgccaact accccagtgc aggcatggct ggaggcataa accccatggg     2880

tgccggaggt caaatgcatg gacagcctgg catcccacct tatggcacac tccctccagg     2940

gaggatgagt cacgcctcca tgggcaaccg gccttatggc cctaacatgg ccaatatgcc     3000

acctcaggtt gggtcaggga tgtgtccccc accagggggc atgaaccgga aaacccaaga     3060

aactgctgtc gccatgcatg ttgctgccaa ctctatccaa aacaggccgc caggctaccc     3120

caatatgaat caagggggca tgatgggaac tggacctcct tatggacaag ggattaatag     3180

tatggctggc atgatcaacc ctcagggacc cccatattcc atgggtggaa ccatggccaa     3240

caattctgca gggatggcag ccagcccaga gatgatgggc cttggggatg taaagttaac     3300

tccagccacc aaaatgaaca acaaggcaga tgggacaccc aagacagaat ccaaatccaa     3360

gaaatccagt tcttctacta caaccaatga gaagatcacc aagttgtatg agctgggtgg     3420

tgagcctgag aggaagatgt gggtggaccg ttatctggcc ttcactgagg agaaggccat     3480

gggcatgaca aatctgcctg ctgtgggtag gaaacctctg gacctctatc gcctctatgt     3540

gtctgtgaag gagattggtg gattgactca ggtcaacaag aacaaaaaat ggcgggaact     3600

tgcaaccaac ctcaatgtgg gcacatcaag cagtgctgcc agctccttga aaaagcagta     3660

tatccagtgt ctctatgcct ttgaatgcaa gattgaacgg ggagaagacc ctcccccaga     3720

catctttgca gctgctgatt ccaagaagtc ccagcccaag atccagcctc cctctcctgc     3780

gggatcagga tctatgcagg ggccccagac tccccagtca accagcagtt ccatggcaga     3840

aggaggagac ttaaagccac caactccagc atccacacca cacagtcaga tccccccatt     3900

gccaggcatg agcaggagca attcagttgg gatccaggat gcctttaatg atggaagtga     3960

ctccacattc cagaagcgga attccatgac tccaaaccct gggtatcagc ccagtatgaa     4020

tacctctgac atgatggggc gcatgtccta tgagccaaat aaggatcctt atggcagcat     4080

gaggaaagct ccagggagtg atcccttcat gtcctcaggg cagggcccca acggcgggat     4140

gggtgacccc tacagtcgtg ctgccggccc tgggctagga aatgtggcga tgggaccacg     4200

acagcactat ccctatggag gtccttatga cagagtgagg acggagcctg gaatagggcc     4260

tgagggaaac atgagcactg gggccccaca gccgaatctc atgccttcca acccagactc     4320

ggggatgtat tctcctagcc gctacccccc gcagcagcag cagcagcagc agcaacgaca     4380

tgattcctat ggcaatcagt tctccaccca aggcacccct tctggcagcc ccttccccag     4440

ccagcagact acaatgtatc aacagcaaca gcaggtatcc agccctgctc ccctgccccg     4500

gccaatggag aaccgcacct ctcctagcaa gtctccattc ctgcactctg ggatgaaaat     4560

gcagaaggca ggtcccccag tacctgcctc gcacatagca cctgcccctg tgcagccccc     4620

catgattcgg cgggatatca ccttcccacc tggctctgtt gaagccacac agcctgtgtt     4680

gaagcagagg aggcggctca caatgaaaga cattggaacc ccggaggcat ggcgggtaat     4740

gatgtccctc aagtctggtc tcctggcaga gagcacatgg gcattagata ccatcaacat     4800

cctgctgtat gatgacaaca gcatcatgac cttcaacctc agtcagctcc cagggttgct     4860

agagctcctt gtagaatatt tccgacgatg cctgattgag atctttggca ttttaaagga     4920

gtatgaggtg ggtgacccag gacagagaac gctactggat cctgggaggt tcagcaaggt     4980

gtctagtcca gctcccatgg agggtgggga agaagaagaa gaacttctag gtcctaaact     5040

agaagaggaa gaagaagagg aagtagttga aaatgatgag gagatagcct tttcaggcaa     5100

ggacaagcca gcttcagaga atagtgagga gaagctgatc agtaagtttg acaagcttcc     5160

agtaaagatc gtacagaaga atgatccatt tgtggtggac tgctcagata agcttgggcg     5220

tgtgcaggag tttgacagtg gcctgctgca ctggcggatt ggtggggggg acaccactga     5280

gcatatccag acccacttcg agagcaagac agagctgctg ccttcccggc ctcacgcacc     5340

ctgcccacca gcccctcgga agcatgtgac aacagcagag ggtacaccag ggacaacaga     5400

ccaggagggg cccccacctg atggacctcc agaaaaacgg atcacagcca ctatggatga     5460

catgttgtct actcggtcta gcaccttgac cgaggatgga gctaagagtt cagaggccat     5520

caaggagagc agcaagtttc catttggcat tagcccagca cagagccacc ggaacatcaa     5580

gatcctagag gacgaacccc acagtaagga tgagacccca ctgtgtaccc ttctggactg     5640

gcaggattct cttgccaagc gctgcgtctg tgtgtccaat accattcgaa gcctgtcatt     5700

tgtgccaggc aatgactttg agatgtccaa acacccaggg ctgctgctca tcctgggcaa     5760

gctgatcctg ctgcaccaca agcacccaga acggaagcag gcaccactaa cttatgaaaa     5820

ggaggaggaa caggaccaag gggtgagctg caacaaagtg gagtggtggt gggactgctt     5880

ggagatgctc cgggaaaaca ccttggttac actcgccaac atctcggggc agttggacct     5940

atctccatac cccgagagca tttgcctgcc tgtcctggac ggactcctac actgggcagt     6000

ttgcccttca gctgaagccc aggacccctt ttccaccctg ggccccaatg ccgtcctttc     6060

cccgcagaga ctggtcttgg aaaccctcag caaactcagc atccaggaca acaatgtgga     6120

cctgattctg gccacacccc ccttcagccg cctggagaag ttgtatagca ctatggtgcg     6180

cttcctcagt gaccgaaaga acccggtgtg ccgggagatg gctgtggtac tgctggccaa     6240

cctggctcag ggggacagcc tggcagctcg tgccattgca gtgcagaagg gcagtatcgg     6300

caacctcctg ggcttcctag aggacagcct tgccgccaca cagttccagc agagccaggc     6360

cagcctcctc cacatgcaga acccaccctt tgagccaact agtgtggaca tgatgcggcg     6420

ggctgcccgc gcgctgcttg ccttggccaa ggtggacgag aaccactcag agtttactct     6480

gtacgaatca cggctgttgg acatctcggt atcaccgttg atgaactcat tggtttcaca     6540

agtcatttgt gatgtactgt ttttgattgg ccagtcatga cagccgtggg acacctcccc     6600

cccccgtgtg tgtgtgcgtg tgtggagaac ttagaaactg actgttgccc tttatttatg     6660

caaaaccacc tcagaatcca gtttaccctg tgctgtccag cttctccctt gggaaaaagt     6720

ctctcctgtt tctctctcct ccttccacct cccctccctc catcacctca cgcctttctg     6780

ttccttgtcc tcaccttact cccctcagga ccctacccca ccctctttga aaagacaaag     6840

ctctgcctac atagaagact ttttttattt taaccaaagt tactgttgtt tacagtgagt     6900

ttggggaaaa aaaataaaat aaaaatggct ttcccagtcc ttgcatcaac gggatgccac     6960

atttcataac tgtttttaat ggtaaaaaaa aaaaaaaaaa atacaaaaaa aaattctgaa     7020

ggacaaaaaa ggtgactgct gaactgtgtg tggtttattg ttgtacattc acaatcttgc     7080

aggagccaag aagttcgcag ttgtgaacag accctgttca ctggagaggc ctgtgcagta     7140

gagtgtagac cctttcatgt actgtactgt acacctgata ctgtaaacat actgtaataa     7200

taatgtctca catggaaaca gaaaacgctg ggtcagcagc aagctgtagt ttttaaaaat     7260

gtttttagtt aaacgttgag gagaaaaaaa aaaaaggctt ttcccccaaa gtatcatgtg     7320

tgaacctaca acaccctgac ctctttctct cctccttgat tgtatgaata accctgagat     7380

cacctcttag aactggtttt aacctttagc tgcagcggct acgctgccac gtgtgtatat     7440

atatgacgtt gtacattgca catacccttg gatccccaca gtttggtcct cctcccagct     7500

acccctttat agtatgacga gttaacaagt tggtgacctg cacaaagcga gacacagcta     7560

tttaatctct tgccagatat cgcccctctt ggtgcgatgc tgtacaggtc tctgtaaaaa     7620

gtccttgctg tctcagcagc caatcaactt atagtttatt tttttctggg tttttgtttt     7680

gttttgtttt ctttctaatc gaggtgtgaa aaagttctag gttcagttga agttctgatg     7740

aagaaacaca attgagattt tttcagtgat aaaatctgca tatttgtatt tcaacaatgt     7800

agctaaaact tgatgtaaat tcctcctttt tttccttttt tggcttaatg aatatcattt     7860

attcagtatg aaatctttat actatatgtt ccacgtgtta agaataaatg tacattaaat     7920

cttggtaaga cttt                                                       7934


