                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Carrington, Paul
       Ermakov, Grigori
       Garbaccio, Robert M.
       Seghezzi, Wolfgang M.
       Bianchi, Elisabetta
       Orvieto, Federica
       Gately, Dennis
       Knudsen, Nick
       Manibusan, Anthony
 
<120>  ANTIBODY PEPTIDE CONJUGATES THAT HAVE AGONIST ACTIVITY AT BOTH 
       THE GLUCAGON AND GLUCAGON-LIKE PEPTIDE 1 RECEPTORS

<130>  24171

<150>  62/237,009
<151>  2015-10-05

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 4704


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys conjugated to COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  1

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 4739


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG2-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  2

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  3
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 4740


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  3

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  4
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5058


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG6-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  4

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  5
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5059


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG8-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  5

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  6
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5615


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG24-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  6

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  7
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 6115


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG36-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  7

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5275


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  8

His Xaa Asp Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  9
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5048


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG2-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  10
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5049


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  10

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  11
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5050


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG6-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  11

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  12
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5051


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG8-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  12

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  13
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 6114


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG8-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  13

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  14
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 4840


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to COCH2ONH2

<400>  14

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  15
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 4841


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG2-COCH2ONH2

<400>  15

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  16
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 4842


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<400>  16

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  17
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5009


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG6-COCH2ONH2

<400>  17

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  18
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5010


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG8-COCH2ONH2

<400>  18

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  19
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5799


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<400>  19

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Xaa Asp Phe Val Lys Trp Leu Met Xaa Thr Lys Gln 
            20                  25                  30      


<210>  20
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5052


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG2-COCH2ONH2

<400>  20

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  21
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  Peptide 5053


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<400>  21

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 5314


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG2-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5420


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amide

<400>  23

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr 
            20                  25                  


<210>  24
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5798


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam bridge between E24 and K28

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  24

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr Lys Lys 
            20                  25                  30      


<210>  25
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5759


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is beta-(3-benzothienyl)-alanine (Bzt)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  25

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  26
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5760


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is 7 Azatryptophan (AzTrp)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  26

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  27
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5761


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is 2-naphthylalanine (2Nap)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  27

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  28
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5762


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is (3-Pyridyl)alanine (3Pyr)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  28

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  29
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5763


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  29

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Xaa Lys Lys 
            20                  25                  30      


<210>  30
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide 5764


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is methionine sulfoxide (M(O))

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  30

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr Lys Lys 
            20                  25                  30      


<210>  31
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5765


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is homoleucine (hLeu)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  31

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr Lys Lys 
            20                  25                  30      


<210>  32
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5766


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is homocycloexylalanine (hCha)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  32

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr Lys Lys 
            20                  25                  30      


<210>  33
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6052


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is 3-(2quinoyl)-alanine (3Qui)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  33

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  34
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide 6053


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is 4'-biphenylalanine (Bip)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  34

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  35
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6062


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is N-methyl-tryptophane (Trp(Me))

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  35

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  36
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6376


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Trp(Me)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  36

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Xaa Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  37
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6377


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is hexafluoroleucine (HFL)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  37

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Xaa Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  38
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6378


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is 5-hydroxy tryptophan (W(5OH))

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  38

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  39
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6379


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  39

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Lys Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  40
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6380


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  40

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Gln Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  41
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6381


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<400>  41

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Asn Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  42
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6383


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is alpha-methylphenylalanine (aMePhe)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  42

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  43
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6383


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  43

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  44
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6384


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is alpha-methyl-leucine (aMeLeu)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  44

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  45
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide 6385


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is alpha-methyltryptophan (aMeTrp)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  45

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  46
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6386


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is beta homo tryptophan (bhoTrp)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<400>  46

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Xaa Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  47
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 4699


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys conjugated to COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<400>  47

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  48
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 4700


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to gammaE-COCH2ONH2

<400>  48

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  49
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 4701


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys is conjugated to gammaE-gammaE-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<400>  49

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  50
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 4702


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys is conjugated to PEG2-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<400>  50

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  51
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 4703


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<400>  51

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  52
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pepetide 4896


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys is conjugated to gammaE-gammaE-palmitoyl (C15-CO-)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to COCH2ONH2

<400>  52

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Leu Met Asp Thr Lys Gln 
            20                  25                  30  


<210>  53
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 4952


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys is conjugated to gammaE-gammaE-palmitoyl (C15-CO-)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG2-COCH2ONH2

<400>  53

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  54
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 4953


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys is conjugated to gammaE-gammaE-palmitoyl (C15-CO-)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<400>  54

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  55
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 5866


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  55

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Lys 
            20                  25                  30      


<210>  56
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6541


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  56

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Met Xaa Thr Lys Lys 
            20                  25                  30      


<210>  57
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6542


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  57

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Met Xaa Thr Lys Lys 
            20                  25                  30      


<210>  58
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6543


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  C-terminal amide

<400>  58

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Xaa Asp Phe Val Gln Trp Leu Met Xaa Thr Lys Lys 
            20                  25                  30      


<210>  59
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6544


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys is conjugated to PEG4-COCH2ONH2

<400>  59

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Xaa Asp Phe Val Gln Trp Leu Met Xaa Thr Lys Lys 
            20                  25                  30      


<210>  60
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6545


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG24-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<400>  60

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Xaa Asp Phe Val Lys Trp Leu Met Xaa Thr Lys Gln 
            20                  25                  30      


<210>  61
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide 6546


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys is conjugated to PEG24-COCH2ONH2

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is alpha-aminoisobutyric acid (Aib)

<400>  61

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Xaa Asp Phe Val Lys Trp Leu Met Xaa Thr Lys Gln 
            20                  25                  30      


<210>  62
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GCCR-GLP1R Co-agonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  For any peptide only one of Xaa10, Xaa24, or Xaa31 can be Lys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is alpha-aminoisobutyric acid (aib) or D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr when Xaa31 is Lys, or Lys if neither Xaa24 or Xaa31 is
       Lys, or Tyr or Lys if Xaa24 is Lys

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Gln when Xaa10 is Lys, or Gln or aib when Xaa31 is Lys, or
       Lys when Xaa10 and Xaa31 are Tyr and Gln, respectively, or Glu 
       when Xaa28 is Lys,

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is Lys or Gln when Xaa10 or Xaa24 is Lys

<400>  62

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Met Asp Thr Lys Gln 
            20                  25                  30      


<210>  63
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GCCR-GLP1 Co-Agonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  one of Lys10, Lys24, or Lys31 is covalently linked at its epsilon
       amino group to an aminooxy acid residue

<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  optionally, Lys10 may be conjugated at its epsilon amino group to
       palmitic acid if Lys24 is conjugated at its epsilon amino group 
       to aminooxy acid (HOCOCH2ONH2)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is alpha-aminoisobutyric acid (aib) or D-Ser;

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa10 is Tyr when Xaa31 is Lys, or Lys if neither Xaa24 or Xaa31 
       is Lys, or Tyr or Lys if Xaa24 is Lys; optionally, Lys10 may be 
       covalently linked at its epsilon amino group to a fatty acid if 
       Lys24 is covalently linked to aminooxy acid residue

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa12 is Lys or aib when Xaa31 is Lys, with the proviso that when
       Xaa12 is aib, then either Xaa20 or Xaa24 is aib and Xaa10, Xaa25,
       Xaa26, Xaa25, Xaa27, Xaa28, and Xaa29 are Tyr, Trp, Leu, Met, 
       Asp, and Thr, respectively;

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa2 is alpha-aminoisobutyric acid (aib)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa20 is Gln or aib when Xaa24 or Xaa31 is Lys with the proviso 
       that when Xaa20 is aib then Xaa10, Xaa24, Xaa25, Xaa26, Xaa25, 
       Xaa27, Xaa28, and Xaa29 are Tyr, Gln, Trp, Leu, Met, Asp, and 
       Thr, respectively

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Q when Xaa10 is K, or Q or aib when Xaa31 is K, or K 
       when Xaa10 and Xaa31 are Y and Q, respectively, or E when Xaa28 
       is K; proviso when Xaa24 is aib then Xaa10, Xaa25, Xaa26, Xaa27, 
       Xaa28, an Xaa29 are Y, W, L, M, D, and T, respectively

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa25 is W, Q, D, K, aib, aMePhe, aMeLeu, aMeTrp, bhoTrp, 
       5W(5OH), Bzt, AzTrp, 2Nap, 3Pyr, 3Qui, BIP, or NTrp(Me)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  with the proviso that when Xaa25 is  Q, D, K, aib, aMePhe, 
       aMeLeu, aMeTrp, bhoTrp, W(5OH), Bzt, AzTrp, 2Nap, 3Pyr, 3Qui, 
       BIP, or Trp(Me), then Xaa12, Xaa20, Xaa24, Xaa26, and Xaa27 are 
       K, Q, Q, L, and M, respectively, and Xaa31 is K

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa26 is Leu, aib, or hexafluoroleucine (HFL) with the proviso 
       that when Xaa26 is aib or HFL, then Xaa31 is Lys and Xaa12, 
       Xaa20, Xaa24, Xaa25, and Xaa27 are Lys, Gln, Gln, Trp, and Met, 
       respectively

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is Met, M(O), hLeu, or hCha with the proviso that when 
       Xaa27 is  methionine sulfoxide (M(O)), homoleucine (hLeu), or  
       homocycloexylaline (hCha), then Xaa31 is Lys and Xaa12, Xaa20, 
       Xaa24, Xaa25, Xaa26, Xaa28, Xaa29 are Lys, Gln, Gln, Trp, Leu, 
       

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is Asp or aib, or Lys when Xaa24 is Glu, with the proviso 
       that when Xaa28 includes aib then Xaa24 is Lys and Xaa10, Xaa12, 
       Xaa25, Xaa26, Xaa27, Xaa29 are Tyr, Lys, Trp, Leu, Met, and Thr, 
       respectively

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa29 is Thr or aib with the proviso that when Xaa29 is aib then 
       Xaa31 is Lys and Xaa10, Xaa12, Xaa25, Xaa26, Xaa27, Xaa28 are 
       Tyr, Lys, Trp, Leu, Met, Asp, and Thr, respectively

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is Lys or Gln when Xaa10 or Xaa24 is Lys with the proviso 
       that for any peptide only one of Xaa10, Xaa24, or Xaa31 can be 
       Lys

<400>  63

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Xaa Asp Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa 
            20                  25                  30      


<210>  64
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Palivizumab Light Chain

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  65
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody heavy chain

<400>  65

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  66
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ambody heavy chain HS32


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is pAcF

<400>  66

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Xaa 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  67
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ambody heavy chain HQ16


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is pAcF

<400>  67

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Xaa 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  68
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ambody heavy chain HG33


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa is pAcF

<400>  68

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Xaa Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  69
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ambody heavy chain HD56


<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa is pAcF

<400>  69

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Xaa Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  70
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ambody heavy chain HT114


<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Xaa is pAcF

<400>  70

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Xaa Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  71
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ambody light chain LK125


<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  Xaa is pAcF

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Xaa Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  72
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ambody light chain LE142


<220>
<221>  MISC_FEATURE
<222>  (142)..(142)
<223>  Xaa is pAcF

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Xaa Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  73
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ambody heavy chain HS179


<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  Xaa is pAcF

<400>  73

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Xaa Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  74
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ambody heavy chain HT198


<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa is pAcF

<400>  74

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Xaa Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  75
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ambody heavy chain HN211


<220>
<221>  MISC_FEATURE
<222>  (211)..(211)
<223>  Xaa is pAcF

<400>  75

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Xaa Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


