                               SEQUENCE LISTING

<110> CIRCLE33 LLC
 
<120> ANTIBODIES WITH IMPROVED STABILITY TO INTESTINAL DIGESTION

<130> 11020/005408-WO0

<140> PCT/US2016/054304
<141> 2016-09-29

<150> 62/237,270
<151> 2015-10-05

<160> 118   

<170> PatentIn version 3.5

<210> 1
<211> 329
<212> PRT
<213> Bos taurus

<400> 1
Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr 
            20                  25                  30          


Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser Gly Thr Gln Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys 
                85                  90                  95      


Ala Val Asp Pro Arg Cys Lys Thr Thr Cys Asp Cys Cys Pro Pro Pro 
            100                 105                 110         


Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Gly His Asp Asp Pro Glu Val Lys Phe Ser Trp Phe Val Asp 
145                 150                 155                 160 


Asp Val Glu Val Asn Thr Ala Thr Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Ala Leu Arg Ile Gln His Gln Asp 
            180                 185                 190         


Trp Thr Gly Gly Lys Glu Phe Lys Cys Lys Val His Asn Glu Gly Leu 
        195                 200                 205             


Pro Ala Pro Ile Val Arg Thr Ile Ser Arg Thr Lys Gly Pro Ala Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln Glu Glu Leu Ser Lys 
225                 230                 235                 240 


Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser Phe Tyr Pro Asp Tyr 
                245                 250                 255     


Ile Ala Val Glu Trp Gln Arg Asn Gly Gln Pro Glu Ser Glu Asp Lys 
            260                 265                 270         


Tyr Gly Thr Thr Pro Pro Gln Leu Asp Ala Asp Gly Ser Tyr Phe Leu 
        275                 280                 285             


Tyr Ser Arg Leu Arg Val Asp Arg Asn Ser Trp Gln Glu Gly Asp Thr 
    290                 295                 300                 


Tyr Thr Cys Val Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Thr Ser Lys Ser Ala Gly Lys 
                325                 


<210> 2
<211> 329
<212> PRT
<213> Bos taurus

<400> 2
Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr 
            20                  25                  30          


Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser Gly Gln Thr Phe 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Ala 
                85                  90                  95      


Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys Pro Pro Pro 
            100                 105                 110         


Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Gly His Asp Asp Pro Glu Val Lys Phe Ser Trp Phe Val Asp 
145                 150                 155                 160 


Asp Val Glu Val Asn Thr Ala Thr Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Ala Leu Arg Ile Gln His Gln Asp 
            180                 185                 190         


Trp Thr Gly Gly Lys Glu Phe Lys Cys Lys Val His Asn Glu Gly Leu 
        195                 200                 205             


Pro Ala Pro Ile Val Arg Thr Ile Ser Arg Thr Lys Gly Pro Ala Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln Glu Glu Leu Ser Lys 
225                 230                 235                 240 


Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser Phe Tyr Pro Asp Tyr 
                245                 250                 255     


Ile Ala Val Glu Trp Gln Arg Asn Gly Gln Pro Glu Ser Glu Asp Lys 
            260                 265                 270         


Tyr Gly Thr Thr Pro Pro Gln Leu Asp Ala Asp Ser Ser Tyr Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Arg Val Asp Arg Asn Ser Trp Gln Glu Gly Asp Thr 
    290                 295                 300                 


Tyr Thr Cys Val Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Thr Ser Lys Ser Ala Gly Lys 
                325                 


<210> 3
<211> 329
<212> PRT
<213> Bos taurus

<400> 3
Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr 
            20                  25                  30          


Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ala Ser Ser Ser Gly Thr Gln Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys 
                85                  90                  95      


Ala Val Asp Pro Arg Cys Lys Arg Pro Cys Asp Cys Cys Pro Pro Pro 
            100                 105                 110         


Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Gly His Asp Asp Pro Glu Val Lys Phe Ser Trp Phe Val Asp 
145                 150                 155                 160 


Asn Val Glu Val Asn Thr Ala Thr Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Ala Leu Arg Ile Gln His Gln Asp 
            180                 185                 190         


Trp Thr Gly Gly Lys Glu Phe Lys Cys Lys Val His Asn Glu Gly Leu 
        195                 200                 205             


Pro Ala Pro Ile Val Arg Thr Ile Ser Arg Thr Lys Gly Pro Ala Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln Glu Glu Leu Ser Lys 
225                 230                 235                 240 


Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser Phe Tyr Pro Asp Tyr 
                245                 250                 255     


Ile Ala Val Glu Trp Gln Arg Asn Gly Gln Pro Glu Ser Glu Asp Lys 
            260                 265                 270         


Tyr Gly Thr Thr Pro Pro Gln Leu Asp Ala Asp Ser Ser Tyr Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Arg Val Asp Arg Asn Ser Trp Gln Glu Gly Asp Thr 
    290                 295                 300                 


Tyr Thr Cys Val Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Thr Ser Lys Ser Ala Gly Lys 
                325                 


<210> 4
<211> 25
<212> PRT
<213> Bos taurus

<400> 4
Asp Lys Ala Val Asp Pro Arg Cys Lys Pro Ser Pro Cys Asp Cys Cys 
1               5                   10                  15      


Pro Pro Pro Glu Leu Pro Gly Gly Pro 
            20                  25  


<210> 5
<211> 28
<212> PRT
<213> Bos taurus

<400> 5
Val Asp Lys Ala Val Asp Pro Arg Cys Lys Thr Thr Cys Asp Cys Cys 
1               5                   10                  15      


Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
            20                  25              


<210> 6
<211> 28
<212> PRT
<213> Bos taurus

<400> 6
Val Asp Lys Ala Val Asp Pro Arg Cys Lys Arg Pro Cys Asp Cys Cys 
1               5                   10                  15      


Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
            20                  25              


<210> 7
<211> 29
<212> PRT
<213> Bos taurus

<400> 7
Val Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
            20                  25                  


<210> 8
<211> 30
<212> PRT
<213> Ovis aries

<400> 8
Val Asp Lys Arg Val Glu Pro Gly Cys Pro Asp Pro Cys Lys His Cys 
1               5                   10                  15      


Arg Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
            20                  25                  30  


<210> 9
<211> 28
<212> PRT
<213> Lama glama

<400> 9
Val Asp Lys Arg Val Glu Pro His Gly Gly Cys Thr Cys Pro Gln Cys 
1               5                   10                  15      


Pro Ala Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
            20                  25              


<210> 10
<211> 32
<212> PRT
<213> Meriones unguiculatus

<400> 10
Val Asp Lys Thr Val Glu Pro Arg Gly Thr Lys His Ile Cys Pro Asp 
1               5                   10                  15      


Cys Pro Lys Cys Pro Ala Pro Asp Leu Ser Gly Gly Pro Ser Val Phe 
            20                  25                  30          


<210> 11
<211> 34
<212> PRT
<213> Felis catus

<400> 11
Val Asp Lys Thr Val Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro 
1               5                   10                  15      


Cys Asp Cys Pro Lys Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser 
            20                  25                  30          


Ile Phe 
        


<210> 12
<211> 12
<212> PRT
<213> Bos taurus

<400> 12
Asp Pro Arg Cys Lys Thr Thr Cys Asp Cys Cys Pro 
1               5                   10          


<210> 13
<211> 13
<212> PRT
<213> Bos taurus

<400> 13
Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys Pro 
1               5                   10              


<210> 14
<211> 12
<212> PRT
<213> Bos taurus

<400> 14
Asp Pro Arg Cys Lys Arg Pro Cys Asp Cys Cys Pro 
1               5                   10          


<210> 15
<211> 98
<212> PRT
<213> Bos taurus

<400> 15
Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr 
            20                  25                  30          


Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser Gly Thr Gln Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys 
                85                  90                  95      


Ala Val 
        


<210> 16
<211> 97
<212> PRT
<213> Bos taurus

<400> 16
Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr 
            20                  25                  30          


Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser Gly Gln Thr Phe 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Ala 
                85                  90                  95      


Val 
    


<210> 17
<211> 98
<212> PRT
<213> Bos taurus

<400> 17
Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr 
            20                  25                  30          


Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ala Ser Ser Ser Gly Thr Gln Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys 
                85                  90                  95      


Ala Val 
        


<210> 18
<211> 110
<212> PRT
<213> Bos taurus

<400> 18
Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Gly His Asp Asp Pro Glu Val Lys Phe Ser Trp Phe 
        35                  40                  45              


Val Asp Asp Val Glu Val Asn Thr Ala Thr Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Ala Leu Arg Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys Cys Lys Val His Asn Glu 
                85                  90                  95      


Gly Leu Pro Ala Pro Ile Val Arg Thr Ile Ser Arg Thr Lys 
            100                 105                 110 


<210> 19
<211> 110
<212> PRT
<213> Bos taurus

<400> 19
Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Gly His Asp Asp Pro Glu Val Lys Phe Ser Trp Phe 
        35                  40                  45              


Val Asp Asn Val Glu Val Asn Thr Ala Thr Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Ala Leu Arg Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys Cys Lys Val His Asn Glu 
                85                  90                  95      


Gly Leu Pro Ala Pro Ile Val Arg Thr Ile Ser Arg Thr Lys 
            100                 105                 110 


<210> 20
<211> 109
<212> PRT
<213> Bos taurus

<400> 20
Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln Glu 
1               5                   10                  15      


Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser Phe 
            20                  25                  30          


Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn Gly Gln Pro Glu 
        35                  40                  45              


Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu Asp Ala Asp Gly 
    50                  55                  60                  


Ser Tyr Phe Leu Tyr Ser Arg Leu Arg Val Asp Arg Asn Ser Trp Gln 
65                  70                  75                  80  


Glu Gly Asp Thr Tyr Thr Cys Val Val Met His Glu Ala Leu His Asn 
                85                  90                  95      


His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly Lys 
            100                 105                 


<210> 21
<211> 109
<212> PRT
<213> Bos taurus

<400> 21
Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln Glu 
1               5                   10                  15      


Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser Phe 
            20                  25                  30          


Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn Gly Gln Pro Glu 
        35                  40                  45              


Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu Asp Ala Asp Ser 
    50                  55                  60                  


Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp Arg Asn Ser Trp Gln 
65                  70                  75                  80  


Glu Gly Asp Thr Tyr Thr Cys Val Val Met His Glu Ala Leu His Asn 
                85                  90                  95      


His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly Lys 
            100                 105                 


<210> 22

<400> 22
000


<210> 23
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Gln Ala Val Leu Gly Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Tyr 
            20                  25                  30          


Gly Val Glu Trp Tyr Gln Gln Val Pro Gly Ser Gly Leu Arg Thr Ile 
        35                  40                  45              


Ile Tyr Gly Ser Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ala Gly Asp Ser Ser Ser 
                85                  90                  95      


Arg Gly Ala Val Phe Gly Ser Gly Thr Leu Thr Ala Leu Gly Gln Pro 
            100                 105                 110         


Lys Ser Pro Pro Ser Val Thr Leu Phe Pro Pro Ser Thr Glu Glu Leu 
        115                 120                 125             


Asn Gly Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ser Val Thr Val Val Trp Lys Ala Asp Gly Ser Thr Ile Thr Arg 
145                 150                 155                 160 


Asn Val Glu Thr Thr Arg Ala Ser Lys Gln Ser Asn Ser Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Ser Ser Asp Trp Lys Ser Lys Gly 
            180                 185                 190         


Ser Tyr Ser Cys Glu Val Thr His Glu Gly Ser Thr Val Thr Lys Thr 
        195                 200                 205             


Val Lys Pro Ser Glu Cys Ser 
    210                 215 


<210> 24
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Thr Ser Gly Gly Thr Thr Tyr Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Glu Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Val Ser Ser Val Thr Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Thr Tyr Gly Glu Val Gly Asp Gly Ala Ile Ala Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr Cys Lys 
    210                 215                 220                 


Pro Ser Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser 
                245                 250                 255     


Gly Thr Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr 
        275                 280                 285             


Ala Thr Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg 
                325                 330                 335     


Thr Ile Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Ala Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Met Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln 
    370                 375                 380                 


Arg Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val 
                405                 410                 415     


Asp Arg Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser 
        435                 440                 445             


Ala Gly Lys 
    450     


<210> 25
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro 
1               5                   10                  15      


Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Pro 
            20                  25                  30          


Phe 
    


<210> 26
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 27
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr 
225     


<210> 28
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 29
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile 
                245                 250                 255     


Ser Gly Thr Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn 
        275                 280                 285             


Thr Ala Thr Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val 
                325                 330                 335     


Arg Thr Ile Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Val Leu Ala Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu 
        355                 360                 365             


Thr Cys Met Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp 
    370                 375                 380                 


Gln Arg Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Ala Asp Gly Ser Tyr Phe Leu Tyr Ser Arg Leu Arg 
                405                 410                 415     


Val Asp Arg Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys 
        435                 440                 445             


Ser Ala Gly Lys 
    450         


<210> 30
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Lys 
    210                 215                 220                 


Thr Thr Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala 
        275                 280                 285             


Thr Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr 
                325                 330                 335     


Ile Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu 
            340                 345                 350         


Ala Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys 
        355                 360                 365             


Met Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg 
    370                 375                 380                 


Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln 
385                 390                 395                 400 


Leu Asp Ala Asp Gly Ser Tyr Phe Leu Tyr Ser Arg Leu Arg Val Asp 
                405                 410                 415     


Arg Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala 
        435                 440                 445             


Gly Lys 
    450 


<210> 31
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Lys 
    210                 215                 220                 


Ile Asp Cys Ser Lys Cys His Asn Gln Pro Cys Val Arg Glu Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala 
        275                 280                 285             


Thr Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr 
                325                 330                 335     


Ile Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu 
            340                 345                 350         


Ala Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys 
        355                 360                 365             


Met Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg 
    370                 375                 380                 


Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln 
385                 390                 395                 400 


Leu Asp Ala Asp Gly Ser Tyr Phe Leu Tyr Ser Arg Leu Arg Val Asp 
                405                 410                 415     


Arg Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala 
        435                 440                 445             


Gly Lys 
    450 


<210> 32
<211> 474
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Arg 
    210                 215                 220                 


Pro Val Pro Thr Thr Pro Lys Thr Thr Ile Pro Pro Gly Lys Pro Thr 
225                 230                 235                 240 


Thr Gln Glu Ser Glu Val Glu Lys Thr Pro Cys Gln Cys Ser Lys Cys 
                245                 250                 255     


Pro Glu Pro Leu Gly Gly Leu Ser Val Phe Ile Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Gly His Asp Asp Pro Glu Val Lys Phe Ser Trp Phe Val 
    290                 295                 300                 


Asp Asp Val Glu Val Asn Thr Ala Thr Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Tyr Arg Val Val Ser Ala Leu Arg Ile Gln His Gln 
                325                 330                 335     


Asp Trp Thr Gly Gly Lys Glu Phe Lys Cys Lys Val His Asn Glu Gly 
            340                 345                 350         


Leu Pro Ala Pro Ile Val Arg Thr Ile Ser Arg Thr Lys Gly Pro Ala 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln Glu Glu Leu Ser 
    370                 375                 380                 


Lys Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser Phe Tyr Pro Asp 
385                 390                 395                 400 


Tyr Ile Ala Val Glu Trp Gln Arg Asn Gly Gln Pro Glu Ser Glu Asp 
                405                 410                 415     


Lys Tyr Gly Thr Thr Pro Pro Gln Leu Asp Ala Asp Gly Ser Tyr Phe 
            420                 425                 430         


Leu Tyr Ser Arg Leu Arg Val Asp Arg Asn Ser Trp Gln Glu Gly Asp 
        435                 440                 445             


Thr Tyr Thr Cys Val Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Thr Ser Lys Ser Ala Gly Lys 
465                 470                 


<210> 33
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe 
145                 150                 155                 160 


Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala 
            180                 185                 190         


Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys 
        195                 200                 205             


Ser Phe Ser Lys Asn Glu Cys 
    210                 215 


<210> 34
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Gly Gln Pro Lys Ser 
            100                 105                 110         


Pro Pro Ser Val Thr Leu Phe Pro Pro Ser Thr Glu Glu Leu Asn Gly 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ser 
    130                 135                 140                 


Val Thr Val Val Trp Lys Ala Asp Gly Ser Thr Ile Thr Arg Asn Val 
145                 150                 155                 160 


Glu Thr Thr Arg Ala Ser Lys Gln Ser Asn Ser Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Ser Ser Asp Trp Lys Ser Lys Gly Ser Tyr 
            180                 185                 190         


Ser Cys Glu Val Thr His Glu Gly Ser Thr Val Thr Lys Thr Val Lys 
        195                 200                 205             


Pro Ser Glu Cys Ser 
    210             


<210> 35
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys Val 
        115                 120                 125             


Tyr Pro Leu Ser Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser 
    210                 215                 220                 


Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala Thr 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr Ile 
                325                 330                 335     


Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala 
            340                 345                 350         


Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met 
        355                 360                 365             


Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn 
    370                 375                 380                 


Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu 
385                 390                 395                 400 


Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp Arg 
                405                 410                 415     


Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly 
        435                 440                 445             


Lys 
    


<210> 36
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Ser Asp Ala Glu 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe 
145                 150                 155                 160 


Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala 
            180                 185                 190         


Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys 
        195                 200                 205             


Ser Phe Ser Lys Asn Glu Cys 
    210                 215 


<210> 37
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Gly Tyr Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Glu Ser Asn Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Ile Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Trp Asp Tyr Ala Ile Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys 
        115                 120                 125             


Val Tyr Pro Leu Ser Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr Cys Lys Pro 
    210                 215                 220                 


Ser Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala 
        275                 280                 285             


Thr Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr 
                325                 330                 335     


Ile Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu 
            340                 345                 350         


Ala Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys 
        355                 360                 365             


Met Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg 
    370                 375                 380                 


Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln 
385                 390                 395                 400 


Leu Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp 
                405                 410                 415     


Arg Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala 
        435                 440                 445             


Gly Lys 
    450 


<210> 38
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Lys Ser 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu His Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Met Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Gln Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ser Asp Ala Glu Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Thr Gly Thr Val Ser Val Val Cys Leu Val Asn Asp Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln 
145                 150                 155                 160 


Ser Ser Ser Asn Phe Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr 
            180                 185                 190         


Gln Ser His Asn Ala Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr 
        195                 200                 205             


Thr Ala Leu Val Lys Ser Phe Ser Lys Asn Glu Cys 
    210                 215                 220 


<210> 39
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys Val Tyr 
        115                 120                 125             


Pro Leu Ser Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Gly 
            180                 185                 190         


Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro 
    210                 215                 220                 


Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala Thr Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Ala 
    290                 295                 300                 


Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr Ile Ser 
                325                 330                 335     


Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala Pro 
            340                 345                 350         


Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met Val 
        355                 360                 365             


Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn Gly 
    370                 375                 380                 


Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu Asp 
385                 390                 395                 400 


Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp Arg Asn 
                405                 410                 415     


Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly Lys 
        435                 440                 445             


<210> 40
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Ala Glu 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe 
145                 150                 155                 160 


Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala 
            180                 185                 190         


Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys 
        195                 200                 205             


Ser Phe Ser Lys Asn Glu Cys 
    210                 215 


<210> 41
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Val Tyr Ser Gly Asn Thr Asn Tyr Ala Gln Lys Val 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Ser Ser Ser Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Thr 
        115                 120                 125             


Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly Asp Lys Ser Ser 
    130                 135                 140                 


Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met 
            180                 185                 190         


Val Thr Val Pro Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr 
    210                 215                 220                 


Cys Lys Pro Ser Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr 
                245                 250                 255     


Ile Ser Gly Thr Pro Glu Val Thr Cys Val Val Val Asp Val Gly His 
            260                 265                 270         


Asp Asp Pro Glu Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val 
        275                 280                 285             


Asn Thr Ala Thr Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Val Arg Thr Ile Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Ala Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser 
        355                 360                 365             


Leu Thr Cys Met Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu 
    370                 375                 380                 


Trp Gln Arg Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Arg Val Asp Arg Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser 
        435                 440                 445             


Lys Ser Ala Gly Lys 
    450             


<210> 42
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Thr 
            20                  25                  30          


Asp Gly Thr Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Asn 
                85                  90                  95      


Ile Gln Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Ser Asp Ala Glu Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Thr Gly Thr Val Ser Val Val Cys Leu Val Asn Asp Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln 
145                 150                 155                 160 


Ser Ser Ser Asn Phe Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr 
            180                 185                 190         


Gln Ser His Asn Ala Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr 
        195                 200                 205             


Thr Ala Leu Val Lys Ser Phe Ser Lys Asn Glu Cys 
    210                 215                 220 


<210> 43
<211> 444
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Trp Asp Val Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser 
        115                 120                 125             


Cys Cys Gly Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Lys Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser Gly 
            180                 185                 190         


Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys 
    210                 215                 220                 


Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Gly His Asp Asp Pro Glu Val Lys Phe Ser Trp 
            260                 265                 270         


Phe Val Asp Asp Val Glu Val Asn Thr Ala Thr Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Ala Leu Arg Ile Gln 
    290                 295                 300                 


His Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys Cys Lys Val His Asn 
305                 310                 315                 320 


Glu Gly Leu Pro Ala Pro Ile Val Arg Thr Ile Ser Arg Thr Lys Gly 
                325                 330                 335     


Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln Glu Glu 
            340                 345                 350         


Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser Phe Tyr 
        355                 360                 365             


Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn Gly Gln Pro Glu Ser 
    370                 375                 380                 


Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu Asp Ala Asp Ser Ser 
385                 390                 395                 400 


Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp Arg Asn Ser Trp Gln Glu 
                405                 410                 415     


Gly Asp Thr Tyr Thr Cys Val Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly Lys 
        435                 440                 


<210> 44
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Arg Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Ala Glu 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe 
145                 150                 155                 160 


Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala 
            180                 185                 190         


Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys 
        195                 200                 205             


Ser Phe Ser Lys Asn Glu Cys 
    210                 215 


<210> 45
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Gly Asp 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Glu Ile Ser Ala Ala Gly Gly Tyr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Arg Val Ser Phe Glu Ala Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys 
        115                 120                 125             


Val Tyr Pro Leu Ser Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr Cys Lys Pro 
    210                 215                 220                 


Ser Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala 
        275                 280                 285             


Thr Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr 
                325                 330                 335     


Ile Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu 
            340                 345                 350         


Ala Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys 
        355                 360                 365             


Met Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg 
    370                 375                 380                 


Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln 
385                 390                 395                 400 


Leu Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp 
                405                 410                 415     


Arg Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala 
        435                 440                 445             


Gly Lys 
    450 


<210> 46
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Leu Ala Thr Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Glu Pro Glu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ser Asp Ala Glu 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe 
145                 150                 155                 160 


Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala 
            180                 185                 190         


Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys 
        195                 200                 205             


Ser Phe Ser Lys Asn Glu Cys 
    210                 215 


<210> 47
<211> 446
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr His Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Tyr Gly Tyr Tyr Phe Asp Phe Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu 
        115                 120                 125             


Ser Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr 
            180                 185                 190         


Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp 
    210                 215                 220                 


Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala Thr Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Ala Leu Arg 
    290                 295                 300                 


Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys Cys Lys Val 
305                 310                 315                 320 


His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr Ile Ser Arg Thr 
                325                 330                 335     


Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln 
            340                 345                 350         


Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser 
        355                 360                 365             


Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn Gly Gln Pro 
    370                 375                 380                 


Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu Asp Ala Asp 
385                 390                 395                 400 


Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp Arg Asn Ser Trp 
                405                 410                 415     


Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly Lys 
        435                 440                 445     


<210> 48
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Gln Ile Val Ser Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Arg Ser Tyr Met 
            20                  25                  30          


Gln Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Thr Phe Gly 
                85                  90                  95      


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Ala Glu Pro Ser Val 
            100                 105                 110         


Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly Thr Val Ser 
        115                 120                 125             


Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile Asn Val Lys 
    130                 135                 140                 


Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe Gln Asn Ser 
145                 150                 155                 160 


Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu Ser Ser Ile 
                165                 170                 175     


Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala Tyr Thr Cys 
            180                 185                 190         


Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys Ser Phe Ser 
        195                 200                 205             


Lys Asn Glu Cys 
    210         


<210> 49
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser 
        115                 120                 125             


Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser 
            180                 185                 190         


Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys 
    210                 215                 220                 


Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Gly His Asp Asp Pro Glu Val Lys Phe Ser 
            260                 265                 270         


Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala Thr Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Ala Leu Arg Ile 
    290                 295                 300                 


Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys Cys Lys Val His 
305                 310                 315                 320 


Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr Ile Ser Arg Thr Lys 
                325                 330                 335     


Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln Glu 
            340                 345                 350         


Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser Phe 
        355                 360                 365             


Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn Gly Gln Pro Glu 
    370                 375                 380                 


Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu Asp Ala Asp Ser 
385                 390                 395                 400 


Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp Arg Asn Ser Trp Gln 
                405                 410                 415     


Glu Gly Asp Thr Tyr Thr Cys Val Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly Lys 
        435                 440                 445 


<210> 50
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Ala Glu 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe 
145                 150                 155                 160 


Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala 
            180                 185                 190         


Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys 
        195                 200                 205             


Ser Phe Ser Lys Asn Glu Cys 
    210                 215 


<210> 51
<211> 78
<212> PRT
<213> Homo sapiens

<400> 51
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
65                  70                  75              


<210> 52
<211> 77
<212> PRT
<213> Bos taurus

<400> 52
Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr 
            20                  25                  30          


Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser Gly 
65                  70                  75          


<210> 53
<211> 78
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
65                  70                  75              


<210> 54
<211> 78
<212> PRT
<213> Homo sapiens

<400> 54
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
1               5                   10                  15      


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75              


<210> 55
<211> 76
<212> PRT
<213> Bos taurus

<400> 55
Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
1               5                   10                  15      


Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys 
            20                  25                  30          


Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Gly His Asp Asp Pro Glu Val 
65                  70                  75      


<210> 56
<211> 76
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
1               5                   10                  15      


Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys 
            20                  25                  30          


Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75      


<210> 57
<211> 78
<212> PRT
<213> Homo sapiens

<400> 57
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
65                  70                  75              


<210> 58
<211> 77
<212> PRT
<213> Bos taurus

<400> 58
Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr 
            20                  25                  30          


Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser Gly 
65                  70                  75          


<210> 59
<211> 78
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
65                  70                  75              


<210> 60
<211> 74
<212> PRT
<213> Homo sapiens

<400> 60
Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
1               5                   10                  15      


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
            20                  25                  30          


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        35                  40                  45              


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    50                  55                  60                  


Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  


<210> 61
<211> 76
<212> PRT
<213> Bos taurus

<400> 61
Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
1               5                   10                  15      


Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys 
            20                  25                  30          


Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Gly His Asp Asp Pro Glu Val 
65                  70                  75      


<210> 62
<211> 76
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
1               5                   10                  15      


Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys 
            20                  25                  30          


Pro Pro Pro Glu Leu Pro Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75      


<210> 63
<211> 78
<212> PRT
<213> Homo sapiens

<400> 63
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
65                  70                  75              


<210> 64
<211> 77
<212> PRT
<213> Bos taurus

<400> 64
Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr 
            20                  25                  30          


Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser Gly 
65                  70                  75          


<210> 65
<211> 78
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ser Ser Cys Cys Gly 
1               5                   10                  15      


Asp Lys Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
65                  70                  75              


<210> 66
<211> 75
<212> PRT
<213> Homo sapiens

<400> 66
Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
1               5                   10                  15      


Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
            20                  25                  30          


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        35                  40                  45              


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    50                  55                  60                  


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
65                  70                  75  


<210> 67
<211> 76
<212> PRT
<213> Bos taurus

<400> 67
Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
1               5                   10                  15      


Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys 
            20                  25                  30          


Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Gly His Asp Asp Pro Glu Val 
65                  70                  75      


<210> 68
<211> 76
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
1               5                   10                  15      


Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys 
            20                  25                  30          


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
65                  70                  75      


<210> 69
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys Val 
        115                 120                 125             


Tyr Pro Leu Ser Ser Ser Cys Gly Asp Lys Ser Ser Ser Thr Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr Ser Lys Pro Ser 
    210                 215                 220                 


Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala Thr 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr Ile 
                325                 330                 335     


Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala 
            340                 345                 350         


Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met 
        355                 360                 365             


Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn 
    370                 375                 380                 


Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu 
385                 390                 395                 400 


Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp Arg 
                405                 410                 415     


Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly 
        435                 440                 445             


Lys 
    


<210> 70
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Ser Asp Ala Glu 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe 
145                 150                 155                 160 


Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala 
            180                 185                 190         


Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys 
        195                 200                 205             


Ser Phe Ser Lys Asn Glu Cys 
    210                 215 


<210> 71
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys Val 
        115                 120                 125             


Tyr Pro Leu Ser Ser Cys Ser Gly Asp Lys Ser Ser Ser Thr Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr Ser Lys Pro Ser 
    210                 215                 220                 


Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala Thr 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr Ile 
                325                 330                 335     


Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala 
            340                 345                 350         


Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met 
        355                 360                 365             


Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn 
    370                 375                 380                 


Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu 
385                 390                 395                 400 


Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp Arg 
                405                 410                 415     


Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly 
        435                 440                 445             


Lys 
    


<210> 72
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Ser Asp Ala Glu 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe 
145                 150                 155                 160 


Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala 
            180                 185                 190         


Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys 
        195                 200                 205             


Ser Phe Ser Lys Asn Glu Cys 
    210                 215 


<210> 73
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys Val 
        115                 120                 125             


Tyr Pro Leu Ser Ser Ser Ser Gly Asp Lys Ser Ser Ser Thr Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr Cys Lys Pro Ser 
    210                 215                 220                 


Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala Thr 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr Ile 
                325                 330                 335     


Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu Ala 
            340                 345                 350         


Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys Met 
        355                 360                 365             


Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg Asn 
    370                 375                 380                 


Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln Leu 
385                 390                 395                 400 


Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp Arg 
                405                 410                 415     


Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala Gly 
        435                 440                 445             


Lys 
    


<210> 74
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Ser Asp Ala Glu 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Asp Glu Gln Leu Lys Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Thr Gln Ser Ser Ser Asn Phe 
145                 150                 155                 160 


Gln Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Ile Leu Thr Leu Pro Ser Ser Glu Tyr Gln Ser His Asn Ala 
            180                 185                 190         


Tyr Thr Cys Glu Val Ser His Lys Ser Leu Thr Thr Ala Leu Val Lys 
        195                 200                 205             


Ser Phe Ser Lys Asn Glu Cys 
    210                 215 


<210> 75
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Pro Pro Lys Val 
        115                 120                 125             


Tyr Pro Leu Thr Ser Cys Cys Gly Asp Thr Ser Ser Ser Ile Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Ile 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ala Ser Thr Ser Gly Ala Gln Thr Phe Ile Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Arg Val Glu Pro Gly Cys Pro Asp 
    210                 215                 220                 


Pro Cys Lys His Cys Arg Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser 
                245                 250                 255     


Gly Thr Pro Glu Val Thr Cys Val Val Val Asp Val Gly Gln Asp Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asn Val Glu Val Arg Thr 
        275                 280                 285             


Ala Arg Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
    290                 295                 300                 


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val His Asn Glu Ala Leu Pro Ala Pro Ile Val Arg 
                325                 330                 335     


Thr Ile Ser Arg Thr Lys Gly Gln Ala Arg Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Ala Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Leu Ser Val Thr 
        355                 360                 365             


Cys Leu Val Thr Gly Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln 
    370                 375                 380                 


Lys Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Thr Ser 
385                 390                 395                 400 


Gln Leu Asp Ala Asp Gly Ser Tyr Phe Leu Tyr Ser Arg Leu Arg Val 
                405                 410                 415     


Asp Lys Asn Ser Trp Gln Glu Gly Asp Thr Tyr Ala Cys Val Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Lys Pro 
        435                 440                 445             


Pro Gly Lys 
    450     


<210> 76
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Ser Asp Ala Gln 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Lys Pro Ser Glu Glu Gln Leu Arg Thr Gly 
        115                 120                 125             


Thr Val Ser Val Val Cys Leu Val Asn Asp Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Val Lys Val Asp Gly Val Thr Gln Asn Ser Asn Phe Gln 
145                 150                 155                 160 


Asn Ser Phe Thr Asp Gln Asp Ser Lys Lys Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Ser Ser Glu Tyr Gln Ser His Asn Ala Tyr 
            180                 185                 190         


Ala Cys Glu Val Ser His Lys Ser Leu Pro Thr Ala Leu Val Lys Ser 
        195                 200                 205             


Phe Asn Lys Asn Glu Cys 
    210                 


<210> 77
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Pro Pro Lys Val 
        115                 120                 125             


Tyr Pro Leu Thr Ser Cys Cys Gly Asp Thr Ser Ser Ser Ile Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ala Ser Thr Ser Gly Ala Gln Thr Phe Ile Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Arg Val Glu Pro Gly Cys Lys Pro 
    210                 215                 220                 


Ser Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala 
        275                 280                 285             


Thr Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Ala Leu Arg Ile Gln His Gln Asp Trp Thr Gly Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Lys Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg Thr 
                325                 330                 335     


Ile Ser Arg Thr Lys Gly Pro Ala Arg Glu Pro Gln Val Tyr Val Leu 
            340                 345                 350         


Ala Pro Pro Gln Glu Glu Leu Ser Lys Ser Thr Val Ser Leu Thr Cys 
        355                 360                 365             


Met Val Thr Ser Phe Tyr Pro Asp Tyr Ile Ala Val Glu Trp Gln Arg 
    370                 375                 380                 


Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln 
385                 390                 395                 400 


Leu Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys Leu Arg Val Asp 
                405                 410                 415     


Arg Asn Ser Trp Gln Glu Gly Asp Thr Tyr Thr Cys Val Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Thr Ser Lys Ser Ala 
        435                 440                 445             


Gly Lys 
    450 


<210> 78
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Gly Gln Pro Lys Ser 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Thr Glu Glu Leu Asn Ala 
        115                 120                 125             


Asn Lys Ala Thr Val Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ser 
    130                 135                 140                 


Val Thr Val Val Trp Lys Ala Asp Gly Ser Thr Ile Asn Gln Asn Val 
145                 150                 155                 160 


Lys Thr Thr Gln Ala Ser Lys Gln Ser Asn Ser Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Thr Leu Thr Gly Ser Glu Trp Lys Ser Lys Ser Ser Tyr 
            180                 185                 190         


Ser Cys Glu Val Thr His Glu Gly Ser Thr Val Lys Lys Thr Val Lys 
        195                 200                 205             


Pro Ser Glu Cys 
    210         


<210> 79
<211> 443
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Gly Ser Phe Lys Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val 
                165                 170                 175     


Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr 
            180                 185                 190         


Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr 
    210                 215                 220                 


Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr 
            260                 265                 270         


Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg 
        275                 280                 285             


Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile 
    290                 295                 300                 


Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg 
                325                 330                 335     


Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu 
            340                 345                 350         


Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu 
    370                 375                 380                 


Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly 
                405                 410                 415     


Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
        435                 440             


<210> 80
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Gly Asp Pro Val Ala 
            100                 105                 110         


Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly 
        115                 120                 125             


Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr 
    130                 135                 140                 


Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn 
145                 150                 155                 160 


Ser Lys Thr Pro Gln Asp Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr 
            180                 185                 190         


Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg 
        195                 200                 205             


Gly Asp Cys 
    210     


<210> 81
<211> 57
<212> PRT
<213> Homo sapiens

<400> 81
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Val Ser Asn 
        35                  40                  45              


Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    50                  55          


<210> 82
<211> 57
<212> PRT
<213> Bos taurus

<400> 82
Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Gly His Asp Asp Val His Asn 
        35                  40                  45              


Glu Gly Leu Pro Ala Pro Ile Val Arg 
    50                  55          


<210> 83
<211> 57
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Cys Asp Cys Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Thr Ile Ser Gly Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Asp Asp Val His Asn 
        35                  40                  45              


Glu Ala Leu Pro Ala Pro Ile Val Arg 
    50                  55          


<210> 84
<211> 51
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Val Asp Lys Ala Val Thr Ala Arg Arg Pro Val Pro Thr Thr Pro Lys 
1               5                   10                  15      


Thr Thr Ile Pro Pro Gly Lys Pro Thr Thr Pro Lys Ser Glu Val Glu 
            20                  25                  30          


Lys Thr Pro Cys Gln Cys Ser Lys Cys Pro Glu Pro Leu Gly Gly Leu 
        35                  40                  45              


Ser Val Phe 
    50      


<210> 85
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Val Asp Lys Ala Val Asp Pro Arg Cys Lys Pro Ser Pro Cys Asp Cys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
            20                  25                  


<210> 86
<211> 55
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Val Asp Lys Ala Val Thr Ala Arg Arg Pro Val Pro Thr Thr Pro Lys 
1               5                   10                  15      


Thr Thr Ile Pro Pro Gly Lys Pro Thr Thr Pro Lys Ser Glu Val Glu 
            20                  25                  30          


Pro Arg Cys Lys Pro Ser Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu 
        35                  40                  45              


Pro Gly Gly Pro Ser Val Phe 
    50                  55  


<210> 87
<211> 26
<212> PRT
<213> Bos taurus

<400> 87
Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys Pro Pro 
1               5                   10                  15      


Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
            20                  25      


<210> 88
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 88
Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys Val Arg 
1               5                   10                  15      


Glu Pro Ser Val Phe 
            20      


<210> 89
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 89
Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Ser Val Phe 
            20                  25      


<210> 90
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys Pro Pro 
1               5                   10                  15      


Pro Gly Ser Gly Ser Gly Pro Ser Val Phe 
            20                  25      


<210> 91
<211> 24
<212> PRT
<213> Bos taurus

<400> 91
Asp Lys Ala Val Asp Pro Arg Cys Lys Thr Thr Cys Asp Cys Cys Pro 
1               5                   10                  15      


Pro Pro Glu Leu Pro Gly Gly Pro 
            20                  


<210> 92
<211> 28
<212> PRT
<213> Vicugna pacos

<400> 92
Val Asp Lys Arg Val Glu Pro His Gly Gly Cys Thr Cys Pro Gln Cys 
1               5                   10                  15      


Pro Ala Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
            20                  25              


<210> 93
<211> 28
<212> PRT
<213> Camelus dromedarius

<400> 93
Val Asp Lys Arg Val Glu Pro His Gly Gly Cys Thr Cys Pro Gln Cys 
1               5                   10                  15      


Pro Ala Pro Glu Leu Pro Gly Gly Pro Ser Val Phe 
            20                  25              


<210> 94
<211> 27
<212> PRT
<213> Oryctolagus cuniculus

<400> 94
Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro 
1               5                   10                  15      


Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            20                  25          


<210> 95
<211> 53
<212> PRT
<213> Bos taurus

<400> 95
Val Thr Val Pro Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val 
1               5                   10                  15      


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Thr 
            20                  25                  30          


Cys Lys Pro Ser Pro Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly 
        35                  40                  45              


Gly Pro Ser Val Phe 
    50              


<210> 96
<211> 50
<212> PRT
<213> Bos taurus

<400> 96
Val Thr Val Pro Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val 
1               5                   10                  15      


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Ala Val Gly Val Ser 
            20                  25                  30          


Ser Asp Cys Ser Lys Pro Asn Asn Gln His Cys Val Arg Glu Pro Ser 
        35                  40                  45              


Val Phe 
    50  


<210> 97
<211> 50
<212> PRT
<213> Bos taurus

<400> 97
Val Thr Val Pro Ala Ser Ser Ser Gly Gln Thr Phe Thr Cys Asn Val 
1               5                   10                  15      


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Ala Val Gly Val Ser 
            20                  25                  30          


Ile Asp Cys Ser Lys Cys His Asn Gln Pro Cys Val Arg Glu Pro Ser 
        35                  40                  45              


Val Phe 
    50  


<210> 98
<211> 53
<212> PRT
<213> Homo sapiens

<400> 98
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
1               5                   10                  15      


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            20                  25                  30          


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        35                  40                  45              


Gly Pro Ser Val Phe 
    50              


<210> 99
<211> 50
<212> PRT
<213> Bos taurus

<400> 99
Pro Gly Ser Thr Ser Gly Thr Gln Thr Phe Thr Cys Asn Val Ala His 
1               5                   10                  15      


Pro Ala Ser Ser Thr Lys Val Asp Lys Ala Val Asp Pro Arg Cys Lys 
            20                  25                  30          


Thr Thr Cys Asp Cys Cys Pro Pro Pro Glu Leu Pro Gly Gly Pro Ser 
        35                  40                  45              


Val Phe 
    50  


<210> 100
<211> 19
<212> PRT
<213> Bos taurus

<400> 100
Ser Pro Pro Ser Val Thr Leu Phe Pro Pro Ser Thr Glu Glu Leu Asn 
1               5                   10                  15      


Gly Asn Lys 
            


<210> 101
<211> 15
<212> PRT
<213> Bos taurus

<400> 101
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Ser Ser Asp Trp Lys 
1               5                   10                  15  


<210> 102
<211> 29
<212> PRT
<213> Bos taurus

<400> 102
Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Asn Gly Tyr 
1               5                   10                  15      


Val Ser Trp Tyr Gln Leu Ile Pro Gly Ser Ala Pro Arg 
            20                  25                  


<210> 103
<211> 16
<212> PRT
<213> Bos taurus

<400> 103
Gly Ser Tyr Ser Cys Glu Val Thr His Glu Gly Ser Thr Val Thr Lys 
1               5                   10                  15      


<210> 104
<211> 11
<212> PRT
<213> Bos taurus

<400> 104
Val Tyr Pro Leu Ser Ser Cys Cys Gly Asp Lys 
1               5                   10      


<210> 105
<211> 29
<212> PRT
<213> Bos taurus

<400> 105
Ser Ser Ser Thr Val Thr Leu Gly Cys Leu Val Ser Ser Tyr Met Pro 
1               5                   10                  15      


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Lys 
            20                  25                  


<210> 106
<211> 45
<212> PRT
<213> Bos taurus

<400> 106
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
1               5                   10                  15      


Ser Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser Gly Gln Thr 
            20                  25                  30          


Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        35                  40                  45  


<210> 107
<211> 33
<212> PRT
<213> Bos taurus

<400> 107
Ala Val Asp Pro Thr Cys Lys Pro Ser Pro Cys Asp Cys Cys Pro Pro 
1               5                   10                  15      


Pro Glu Leu Pro Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys 
    


<210> 108
<211> 25
<212> PRT
<213> Bos taurus

<400> 108
Asp Thr Leu Thr Ile Ser Gly Thr Pro Glu Val Thr Cys Val Val Asp 
1               5                   10                  15      


Val Gly His Asp Asp Pro Glu Val Lys 
            20                  25  


<210> 109
<211> 18
<212> PRT
<213> Bos taurus

<400> 109
Phe Ser Trp Phe Val Asp Asp Val Glu Val Asn Thr Ala Thr Thr Lys 
1               5                   10                  15      


Pro Arg 
        


<210> 110
<211> 12
<212> PRT
<213> Bos taurus

<400> 110
Val His Asn Glu Gly Leu Pro Ala Pro Ile Val Arg 
1               5                   10          


<210> 111
<211> 16
<212> PRT
<213> Bos taurus

<400> 111
Glu Pro Gln Val Tyr Val Leu Ala Pro Pro Gln Glu Glu Leu Ser Lys 
1               5                   10                  15      


<210> 112
<211> 23
<212> PRT
<213> Bos taurus

<400> 112
Ser Thr Val Ser Leu Thr Cys Met Val Thr Ser Phe Tyr Pro Asp Tyr 
1               5                   10                  15      


Ile Ala Val Glu Trp Gln Arg 
            20              


<210> 113
<211> 28
<212> PRT
<213> Bos taurus

<400> 113
Asn Gly Gln Pro Glu Ser Glu Asp Lys Tyr Gly Thr Thr Pro Pro Gln 
1               5                   10                  15      


Leu Asp Ala Asp Ser Ser Tyr Phe Leu Tyr Ser Lys 
            20                  25              


<210> 114
<211> 16
<212> PRT
<213> Bos taurus

<400> 114
Glu Pro Gln Val Tyr Val Leu Asp Pro Pro Lys Glu Glu Leu Ser Lys 
1               5                   10                  15      


<210> 115
<211> 10
<212> PRT
<213> Bos taurus

<400> 115
Thr Thr Pro Pro Gln Leu Asp Ala Asp Arg 
1               5                   10  


<210> 116
<211> 12
<212> PRT
<213> Bos taurus

<400> 116
Glu Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
1               5                   10          


<210> 117
<211> 16
<212> PRT
<213> Bos taurus

<400> 117
Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Thr Gly Gly Lys 
1               5                   10                  15      


<210> 118
<211> 20
<212> PRT
<213> Bos taurus

<400> 118
Gly Asp Thr Tyr Thr Cys Val Val Met His Glu Ala Leu His Asn His 
1               5                   10                  15      


Tyr Met Gln Lys 
            20  


