                         SEQUENCE LISTING

<110>  Genefron Ltd.
 
<120>  METHODS AND KITS FOR PREDICTION AND DIAGNOSIS OF HUMAN 
       CYTOMEGALOVIRUS CONGENITAL (hCMV) TRANSMISSION

<130>  2446870

<150>  US 62/239,609
<151>  2015-10-09

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  685
<212>  DNA
<213>  Homo sapiens

<400>  1
ataatagggc cggtgctgcc tgccgaagcc ggcggctgag aggcagcgaa ctcatctttg       60

ccagtacagg agcttgtgcc gtggcccaca gcccacagcc cacagccatg ggctgggacc      120

tgacggtgaa gatgctggcg ggcaacgaat tccaggtgtc cctgagcagc tccatgtcgg      180

tgtcagagct gaaggcgcag atcacccaga agatcggcgt gcacgccttc cagcagcgtc      240

tggctgtcca cccgagcggt gtggcgctgc aggacagggt cccccttgcc agccagggcc      300

tgggccccgg cagcacggtc ctgctggtgg tggacaaatg cgacgaacct ctgagcatcc      360

tggtgaggaa taacaagggc cgcagcagca cctacgaggt acggctgacg cagaccgtgg      420

cccacctgaa gcagcaagtg agcgggctgg agggtgtgca ggacgacctg ttctggctga      480

ccttcgaggg gaagcccctg gaggaccagc tcccgctggg ggagtacggc ctcaagcccc      540

tgagcaccgt gttcatgaat ctgcgcctgc ggggaggcgg cacagagcct ggcgggcgga      600

gctaagggcc tccaccagca tccgagcagg atcaagggcc ggaaataaag gctgttgtaa      660

agagaaaaaa aaaaaaaaaa aaaaa                                            685


<210>  2
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Trp Asp Leu Thr Val Lys Met Leu Ala Gly Asn Glu Phe Gln 
1               5                   10                  15      


Val Ser Leu Ser Ser Ser Met Ser Val Ser Glu Leu Lys Ala Gln Ile 
            20                  25                  30          


Thr Gln Lys Ile Gly Val His Ala Phe Gln Gln Arg Leu Ala Val His 
        35                  40                  45              


Pro Ser Gly Val Ala Leu Gln Asp Arg Val Pro Leu Ala Ser Gln Gly 
    50                  55                  60                  


Leu Gly Pro Gly Ser Thr Val Leu Leu Val Val Asp Lys Cys Asp Glu 
65                  70                  75                  80  


Pro Leu Ser Ile Leu Val Arg Asn Asn Lys Gly Arg Ser Ser Thr Tyr 
                85                  90                  95      


Glu Val Arg Leu Thr Gln Thr Val Ala His Leu Lys Gln Gln Val Ser 
            100                 105                 110         


Gly Leu Glu Gly Val Gln Asp Asp Leu Phe Trp Leu Thr Phe Glu Gly 
        115                 120                 125             


Lys Pro Leu Glu Asp Gln Leu Pro Leu Gly Glu Tyr Gly Leu Lys Pro 
    130                 135                 140                 


Leu Ser Thr Val Phe Met Asn Leu Arg Leu Arg Gly Gly Gly Thr Glu 
145                 150                 155                 160 


Pro Gly Gly Arg Ser 
                165 


<210>  3
<211>  2464
<212>  DNA
<213>  Homo sapiens

<400>  3
actttccttt cccctttcat aaaagcacag acctaacagc accctgggtg gaaacctctt       60

cagcatttgc ttggaatcag taagctaaaa acaaaatcaa ccgggacccc agcttttcag      120

aactgcaggg aaacagccat catgagtgag gtcaccaaga attccctgga gaaaatcctt      180

ccacagctga aatgccattt cacctggaac ttattcaagg aagacagtgt ctcaagggat      240

ctagaagata gagtgtgtaa ccagattgaa tttttaaaca ctgagttcaa agctacaatg      300

tacaacttgt tggcctacat aaaacaccta gatggtaaca acgaggcagc cctggaatgc      360

ttacggcaag ctgaagagtt aatccagcaa gaacatgctg accaagcaga aatcagaagt      420

ctagtcactt ggggaaacta cgcctgggtc tactatcact tgggcagact ctcagatgct      480

cagatttatg tagataaggt gaaacaaacc tgcaagaaat tttcaaatcc atacagtatt      540

gagtattctg aacttgactg tgaggaaggg tggacacaac tgaagtgtgg aagaaatgaa      600

agggcgaagg tgtgttttga gaaggctctg gaagaaaagc ccaacaaccc agaattctcc      660

tctggactgg caattgcgat gtaccatctg gataatcacc cagagaaaca gttctctact      720

gatgttttga agcaggccat tgagctgagt cctgataacc aatacgtcaa ggttctcttg      780

ggcctgaaac tgcagaagat gaataaagaa gctgaaggag agcagtttgt tgaagaagcc      840

ttggaaaagt ctccttgcca aacagatgtc ctccgcagtg cagccaaatt ttacagaaga      900

aaaggtgacc tagacaaagc tattgaactg tttcaacggg tgttggaatc cacaccaaac      960

aatggctacc tctatcacca gattgggtgc tgctacaagg caaaagtaag acaaatgcag     1020

aatacaggag aatctgaagc tagtggaaat aaagagatga ttgaagcact aaagcaatat     1080

gctatggact attcgaataa agctcttgag aagggactga atcctctgaa tgcatactcc     1140

gatctcgctg agttcctgga gacggaatgt tatcagacac cattcaataa ggaagtccct     1200

gatgctgaaa agcaacaatc ccatcagcgc tactgcaacc ttcagaaata taatgggaag     1260

tctgaagaca ctgctgtgca acatggttta gagggtttgt ccataagcaa aaaatcaact     1320

gacaaggaag agatcaaaga ccaaccacag aatgtatctg aaaatctgct tccacaaaat     1380

gcaccaaatt attggtatct tcaaggatta attcataagc agaatggaga tctgctgcaa     1440

gcagccaaat gttatgagaa ggaactgggc cgcctgctaa gggatgcccc ttcaggcata     1500

ggcagtattt tcctgtcagc atctgagctt gaggatggta gtgaggaaat gggccagggc     1560

gcagtcagct ccagtcccag agagctcctc tctaactcag agcaactgaa ctgagacaga     1620

ggaggaaaac agagcatcag aagcctgcag tggtggttgt gacgggtagg acgataggaa     1680

gacagggggc cccaacctgg gattgctgag cagggaagct ttgcatgttg ctctaaggta     1740

catttttaaa gagttgtttt ttggccgggc gcagtggctc atgcctgtaa tcccagcact     1800

ttgggaggcc gaggtgggcg gatcacgagg tctggagttt gagaccatcc tggctaacac     1860

agtgaaatcc cgtctctact aaaaatacaa aaaattagcc aggcgtggtg gctggcacct     1920

gtagtcccag ctacttggga ggctgaggca ggagaatggc gtgaacctgg aaggaagagg     1980

ttgcagtgag ccaagattgc gcccctgcac tccagcctgg gcaacagagc aagactccat     2040

ctcaaaaaaa aaaaaaaaaa aaaaaaagag ttgttttctc atgttcatta tagttcatta     2100

cagttacata gtccgaaggt cttacaacta atcactggta gcaataaatg cttcaggccc     2160

acatgatgct gattagttct cagttttcat tcagttcaca atataaccac cattcctgcc     2220

ctccctgcca agggtcataa atggtgactg cctaacaaca aaatttgcag tctcatctca     2280

ttttcatcca gacttctgga actcaaagat taacttttga ctaaccctgg aatatctctt     2340

atctcactta tagcttcagg catgtattta tatgtattct tgatagcaat accataatca     2400

atgtgtattc ctgatagtaa tgctacaata aatccaaaca tttcaactct gttaaaaaaa     2460

aaaa                                                                  2464


<210>  4
<211>  2552
<212>  DNA
<213>  Homo sapiens

<400>  4
attttcctcc tcccaacgat tttaaattag tttcactttc cagtttcctc ttccttcccc       60

taaaagcaat tactcaaaaa cggagaaaac atcagctgat gcgtgcccta ctctcccacc      120

cctttatata gttccttcag tatttacttg aggcagacag gaagacttct gaagaacaaa      180

tcagcctggt caccagcttt tcggaacagc agagacacag agggcagtca tgagtgaggt      240

caccaagaat tccctggaga aaatccttcc acagctgaaa tgccatttca cctggaactt      300

attcaaggaa gacagtgtct caagggatct agaagataga gtgtgtaacc agattgaatt      360

tttaaacact gagttcaaag ctacaatgta caacttgttg gcctacataa aacacctaga      420

tggtaacaac gaggcagccc tggaatgctt acggcaagct gaagagttaa tccagcaaga      480

acatgctgac caagcagaaa tcagaagtct agtcacttgg ggaaactacg cctgggtcta      540

ctatcacttg ggcagactct cagatgctca gatttatgta gataaggtga aacaaacctg      600

caagaaattt tcaaatccat acagtattga gtattctgaa cttgactgtg aggaagggtg      660

gacacaactg aagtgtggaa gaaatgaaag ggcgaaggtg tgttttgaga aggctctgga      720

agaaaagccc aacaacccag aattctcctc tggactggca attgcgatgt accatctgga      780

taatcaccca gagaaacagt tctctactga tgttttgaag caggccattg agctgagtcc      840

tgataaccaa tacgtcaagg ttctcttggg cctgaaactg cagaagatga ataaagaagc      900

tgaaggagag cagtttgttg aagaagcctt ggaaaagtct ccttgccaaa cagatgtcct      960

ccgcagtgca gccaaatttt acagaagaaa aggtgaccta gacaaagcta ttgaactgtt     1020

tcaacgggtg ttggaatcca caccaaacaa tggctacctc tatcaccaga ttgggtgctg     1080

ctacaaggca aaagtaagac aaatgcagaa tacaggagaa tctgaagcta gtggaaataa     1140

agagatgatt gaagcactaa agcaatatgc tatggactat tcgaataaag ctcttgagaa     1200

gggactgaat cctctgaatg catactccga tctcgctgag ttcctggaga cggaatgtta     1260

tcagacacca ttcaataagg aagtccctga tgctgaaaag caacaatccc atcagcgcta     1320

ctgcaacctt cagaaatata atgggaagtc tgaagacact gctgtgcaac atggtttaga     1380

gggtttgtcc ataagcaaaa aatcaactga caaggaagag atcaaagacc aaccacagaa     1440

tgtatctgaa aatctgcttc cacaaaatgc accaaattat tggtatcttc aaggattaat     1500

tcataagcag aatggagatc tgctgcaagc agccaaatgt tatgagaagg aactgggccg     1560

cctgctaagg gatgcccctt caggcatagg cagtattttc ctgtcagcat ctgagcttga     1620

ggatggtagt gaggaaatgg gccagggcgc agtcagctcc agtcccagag agctcctctc     1680

taactcagag caactgaact gagacagagg aggaaaacag agcatcagaa gcctgcagtg     1740

gtggttgtga cgggtaggac gataggaaga cagggggccc caacctggga ttgctgagca     1800

gggaagcttt gcatgttgct ctaaggtaca tttttaaaga gttgtttttt ggccgggcgc     1860

agtggctcat gcctgtaatc ccagcacttt gggaggccga ggtgggcgga tcacgaggtc     1920

tggagtttga gaccatcctg gctaacacag tgaaatcccg tctctactaa aaatacaaaa     1980

aattagccag gcgtggtggc tggcacctgt agtcccagct acttgggagg ctgaggcagg     2040

agaatggcgt gaacctggaa ggaagaggtt gcagtgagcc aagattgcgc ccctgcactc     2100

cagcctgggc aacagagcaa gactccatct caaaaaaaaa aaaaaaaaaa aaaaagagtt     2160

gttttctcat gttcattata gttcattaca gttacatagt ccgaaggtct tacaactaat     2220

cactggtagc aataaatgct tcaggcccac atgatgctga ttagttctca gttttcattc     2280

agttcacaat ataaccacca ttcctgccct ccctgccaag ggtcataaat ggtgactgcc     2340

taacaacaaa atttgcagtc tcatctcatt ttcatccaga cttctggaac tcaaagatta     2400

acttttgact aaccctggaa tatctcttat ctcacttata gcttcaggca tgtatttata     2460

tgtattcttg atagcaatac cataatcaat gtgtattcct gatagtaatg ctacaataaa     2520

tccaaacatt tcaactctgt taaaaaaaaa aa                                   2552


<210>  5
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210>  6
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210>  7
<211>  2037
<212>  DNA
<213>  Homo sapiens

<400>  7
gggaagctcg ggccggcagg gtttccccgc acgctggcgc ccagctcccg gcgcggaggc       60

cgctgtaagt ttcgctttcc attcagtgga aaacgaaagc tgggcggggt gccacgagcg      120

cggggccaga ccaaggcggg cccggagcgg aacttcggtc ccagctcggt ccccggctca      180

gtcccgacgt ggaactcagc agcggaggct ggacgcttgc atggcgcttg agagattcca      240

tcgtgcctgg ctcacataag cgcttcctgg aagtgaagtc gtgctgtcct gaacgcgggc      300

caggcagctg cggcctgggg gttttggagt gatcacgaat gagcaaggcg tttgggctcc      360

tgaggcaaat ctgtcagtcc atcctggctg agtcctcgca gtccccggca gatcttgaag      420

aaaagaagga agaagacagc aacatgaaga gagagcagcc cagagagcgt cccagggcct      480

gggactaccc tcatggcctg gttggtttac acaacattgg acagacctgc tgccttaact      540

ccttgattca ggtgttcgta atgaatgtgg acttcaccag gatattgaag aggatcacgg      600

tgcccagggg agctgacgag cagaggagaa gcgtcccttt ccagatgctt ctgctgctgg      660

agaagatgca ggacagccgg cagaaagcag tgcggcccct ggagctggcc tactgcctgc      720

agaagtgcaa cgtgcccttg tttgtccaac atgatgctgc ccaactgtac ctcaaactct      780

ggaacctgat taaggaccag atcactgatg tgcacttggt ggagagactg caggccctgt      840

atacgatccg ggtgaaggac tccttgattt gcgttgactg tgccatggag agtagcagaa      900

acagcagcat gctcaccctc ccactttctc tttttgatgt ggactcaaag cccctgaaga      960

cactggagga cgccctgcac tgcttcttcc agcccaggga gttatcaagc aaaagcaagt     1020

gcttctgtga gaactgtggg aagaagaccc gtgggaaaca ggtcttgaag ctgacccatt     1080

tgccccagac cctgacaatc cacctcatgc gattctccat caggaattca cagacgagaa     1140

agatctgcca ctccctgtac ttcccccaga gcttggattt cagccagatc cttccaatga     1200

agcgagagtc ttgtgatgct gaggagcagt ctggagggca gtatgagctt tttgctgtga     1260

ttgcgcacgt gggaatggca gactccggtc attactgtgt ctacatccgg aatgctgtgg     1320

atggaaaatg gttctgcttc aatgactcca atatttgctt ggtgtcctgg gaagacatcc     1380

agtgtaccta cggaaatcct aactaccact ggcaggaaac tgcatatctt ctggtttaca     1440

tgaagatgga gtgctaatgg aaatgcccaa aaccttcaga gattgacacg ctgtcatttt     1500

ccatttccgt tcctggatct acggagtctt ctaagagatt ttgcaatgag gagaagcatt     1560

gttttcaaac tatataactg agccttattt ataattaggg atattatcaa aatatgtaac     1620

catgaggccc ctcaggtcct gatcagtcag aatggatgct ttcaccagca gacccggcca     1680

tgtggctgct cggtcctggg tgctcgctgc tgtgcaagac attagccctt tagttatgag     1740

cctgtgggaa cttcaggggt tcccagtggg gagagcagtg gcagtgggag gcatctgggg     1800

gccaaaggtc agtggcaggg ggtatttcag tattatacaa ctgctgtgac cagacttgta     1860

tactggctga atatcagtgc tgtttgtaat ttttcacttt gagaaccaac attaattcca     1920

tatgaatcaa gtgttttgta actgctattc atttattcag caaatattta ttgatcatct     1980

cttctccata agatagtgtg ataaacacag tcatgaataa agttattttc cacaaaa        2037


<210>  8
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Lys Ala Phe Gly Leu Leu Arg Gln Ile Cys Gln Ser Ile Leu 
1               5                   10                  15      


Ala Glu Ser Ser Gln Ser Pro Ala Asp Leu Glu Glu Lys Lys Glu Glu 
            20                  25                  30          


Asp Ser Asn Met Lys Arg Glu Gln Pro Arg Glu Arg Pro Arg Ala Trp 
        35                  40                  45              


Asp Tyr Pro His Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Thr 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Arg Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Cys Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Thr Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Thr Ile Arg Val Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Val Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Pro Leu Ser Leu Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp Gln Glu Thr Ala Tyr Leu Leu Val Tyr Met 
        355                 360                 365             


Lys Met Glu Cys 
    370         


<210>  9
<211>  4127
<212>  DNA
<213>  Homo sapiens

<400>  9
agcagacgag ggcttgtgcg agagggggcc gggcggctgc agggaaggcg gagtccaagg       60

ggaaaacgaa actgagaacc agctctcccg aagccgcggg tctccggccg gcggcggcgg      120

cggcggcggc ggcggcgcag tttctggagc aaattcagtt tgccttcctg gatttgtaaa      180

ttgtaatgac ctcaaaactt tagcagttct tccatctgac tcaggtttgc ttctctggcg      240

gtcttcagaa tcaacatcca cacttccgtg attatctgcg tgcattttgg acaaagcttc      300

caaccaggat acgggaagaa gaaatggctg gtgatctttc agcaggtttc ttcatggagg      360

aacttaatac ataccgtcag aagcagggag tagtacttaa atatcaagaa ctgcctaatt      420

caggacctcc acatgatagg aggtttacat ttcaagttat aatagatgga agagaatttc      480

cagaaggtga aggtagatca aagaaggaag caaaaaatgc cgcagccaaa ttagctgttg      540

agatacttaa taaggaaaag aaggcagtta gtcctttatt attgacaaca acgaattctt      600

cagaaggatt atccatgggg aattacatag gccttatcaa tagaattgcc cagaagaaaa      660

gactaactgt aaattatgaa cagtgtgcat cgggggtgca tgggccagaa ggatttcatt      720

ataaatgcaa aatgggacag aaagaatata gtattggtac aggttctact aaacaggaag      780

caaaacaatt ggccgctaaa cttgcatatc ttcagatatt atcagaagaa acctcagtga      840

aatctgacta cctgtcctct ggttcttttg ctactacgtg tgagtcccaa agcaactctt      900

tagtgaccag cacactcgct tctgaatcat catctgaagg tgacttctca gcagatacat      960

cagagataaa ttctaacagt gacagtttaa acagttcttc gttgcttatg aatggtctca     1020

gaaataatca aaggaaggca aaaagatctt tggcacccag atttgacctt cctgacatga     1080

aagaaacaaa gtatactgtg gacaagaggt ttggcatgga ttttaaagaa atagaattaa     1140

ttggctcagg tggatttggc caagttttca aagcaaaaca cagaattgac ggaaagactt     1200

acgttattaa acgtgttaaa tataataacg agaaggcgga gcgtgaagta aaagcattgg     1260

caaaacttga tcatgtaaat attgttcact acaatggctg ttgggatgga tttgattatg     1320

atcctgagac cagtgatgat tctcttgaga gcagtgatta tgatcctgag aacagcaaaa     1380

atagttcaag gtcaaagact aagtgccttt tcatccaaat ggaattctgt gataaaggga     1440

ccttggaaca atggattgaa aaaagaagag gcgagaaact agacaaagtt ttggctttgg     1500

aactctttga acaaataaca aaaggggtgg attatataca ttcaaaaaaa ttaattcata     1560

gagatcttaa gccaagtaat atattcttag tagatacaaa acaagtaaag attggagact     1620

ttggacttgt aacatctctg aaaaatgatg gaaagcgaac aaggagtaag ggaactttgc     1680

gatacatgag cccagaacag atttcttcgc aagactatgg aaaggaagtg gacctctacg     1740

ctttggggct aattcttgct gaacttcttc atgtatgtga cactgctttt gaaacatcaa     1800

agtttttcac agacctacgg gatggcatca tctcagatat atttgataaa aaagaaaaaa     1860

ctcttctaca gaaattactc tcaaagaaac ctgaggatcg acctaacaca tctgaaatac     1920

taaggacctt gactgtgtgg aagaaaagcc cagagaaaaa tgaacgacac acatgttaga     1980

gcccttctga aaaagtatcc tgcttctgat atgcagtttt ccttaaatta tctaaaatct     2040

gctagggaat atcaatagat atttaccttt tattttaatg tttcctttaa ttttttacta     2100

tttttactaa tctttctgca gaaacagaaa ggttttcttc tttttgcttc aaaaacattc     2160

ttacatttta ctttttcctg gctcatctct ttattctttt ttttttttta aagacagagt     2220

ctcgctctgt tgcccaggct ggagtgcaat gacacagtct tggctcactg caacttctgc     2280

ctcttgggtt caagtgattc tcctgcctca gcctcctgag tagctggatt acaggcatgt     2340

gccacccacc caactaattt ttgtgttttt aataaagaca gggtttcacc atgttggcca     2400

ggctggtctc aaactcctga cctcaagtaa tccacctgcc tcggcctccc aaagtgctgg     2460

gattacaggg atgagccacc gcgcccagcc tcatctcttt gttctaaaga tggaaaaacc     2520

acccccaaat tttcttttta tactattaat gaatcaatca attcatatct atttattaaa     2580

tttctaccgc ttttaggcca aaaaaatgta agatcgttct ctgcctcaca tagcttacaa     2640

gccagctgga gaaatatggt actcattaaa aaaaaaaaaa aaagtgatgt acaaccactt     2700

cggaaaacaa tttggcatta tctagtaaag ttgaatccat gtatacccac atagctatca     2760

attctattcc tacatacgtg cttacaagaa tgtccataaa accctgttta taatagccaa     2820

aagaacaggg aacaaccata atgcacatca aaagaagaat ggattaaaaa aattatattc     2880

acacacagga gtactatata gtattgaaaa caattgaagt acagctaaat gtaataacgt     2940

aacacaatac aactctcaga aacataatgt taagcgaaca aagcaggttt tcagaaaata     3000

tatgcagaat aattccattt atataaagtt ccagagcatg caaaactaaa tcattttgta     3060

taaaaaaccc aacaaatgtg atgagacaat aatgggaagg aagggaatga gaaatattaa     3120

attctggatg gtggttatct ttgagggagg ggaatgatgt gattggggaa atggactttc     3180

aaaggtaatg gtaacttcct taagctggat ggtaggtcca ctagtgtttg ctgcatagtt     3240

atacctttta tcttaaatac attttgtatc tattgtaaca accactttaa agacaaccgt     3300

gctgtaaggc agtagctaaa aacagaaaat agtccatcgg gaagggtaag atggctttct     3360

gctgagcaca gggctagaag tgacagccca gtgggccttc caactatatg ccagggtgtt     3420

agatgagtag agaggagacc acccaggaag tctggacaag gggtctggca tgagctctgg     3480

agaagatata tttgaggaac atggggtatg ctagtttgtt gtcctgaatt gctgtagaga     3540

agataattta aattgcatct tagaagacga ccctgagggt gaatttcaac ttagggcaat     3600

tgttttagtt tgtttcttat tggtttaaat ggatacttga agctggataa tttataagga     3660

aaagagattt atatgactta cagttctgca ggctgtacaa gaaacatggc accagcatct     3720

gcttcttccc cggctgcttc cactcatggt ggaaggtgaa ggggagccgg atgtgcagag     3780

atcatatggc aagagaggaa gcaagagagc gagggagaag gtgccaggct ctttttaaat     3840

aaccggctct tgagggaact aatagattga gaactccttg cttctcctcc ccagcacacc     3900

ccacccccag ggacggcatt aatgtattca tgaggggtct tcccccatga cccaaacacc     3960

tcccatcagg ccccacctcc aacactggga tcaaatttca acatgagatt ttgggggaca     4020

aacatgcaaa ctatagcagc aaccagctac cattctaaaa ctgccatatg attttaggat     4080

ttttaaaaag ggccaaattt aggttaagca aaaaaaaaaa aaaaaaa                   4127


<210>  10
<211>  3697
<212>  DNA
<213>  Homo sapiens

<400>  10
gatacgggaa gaagaaatgg ctggtgatct ttcagcaggt ttcttcatgg aggaacttaa       60

tacataccgt cagaagcagg gagtagtact taaatatcaa gaactgccta attcaggacc      120

tccacatgat aggaggttta catttcaagt tataatagat ggaagagaat ttccagaagg      180

tgaaggtaga tcaaagaagg aagcaaaaaa tgccgcagcc aaattagctg ttgagatact      240

taataaggaa aagaaggcag ttagtccttt attattgaca acaacgaatt cttcagaagg      300

attatccatg gggaattaca taggccttat caatagaatt gcccagaaga aaagactaac      360

tgtaaattat gaacagtgtg catcgggggt gcatgggcca gaaggatttc attataaatg      420

caaaatggga cagaaagaat atagtattgg tacaggttct actaaacagg aagcaaaaca      480

attggccgct aaacttgcat atcttcagat attatcagaa gaaacctcag tgaaatctga      540

ctacctgtcc tctggttctt ttgctactac gtgtgagtcc caaagcaact ctttagtgac      600

cagcacactc gcttctgaat catcatctga aggtgacttc tcagcagata catcagagat      660

aaattctaac agtgacagtt taaacagttc ttcgttgctt atgaatggtc tcagaaataa      720

tcaaaggaag gcaaaaagat ctttggcacc cagatttgac cttcctgaca tgaaagaaac      780

aaagtatact gtggacaaga ggaaggcgga gcgtgaagta aaagcattgg caaaacttga      840

tcatgtaaat attgttcact acaatggctg ttgggatgga tttgattatg atcctgagac      900

cagtgatgat tctcttgaga gcagtgatta tgatcctgag aacagcaaaa atagttcaag      960

gtcaaagact aagtgccttt tcatccaaat ggaattctgt gataaaggga ccttggaaca     1020

atggattgaa aaaagaagag gcgagaaact agacaaagtt ttggctttgg aactctttga     1080

acaaataaca aaaggggtgg attatataca ttcaaaaaaa ttaattcata gagatcttaa     1140

gccaagtaat atattcttag tagatacaaa acaagtaaag attggagact ttggacttgt     1200

aacatctctg aaaaatgatg gaaagcgaac aaggagtaag ggaactttgc gatacatgag     1260

cccagaacag atttcttcgc aagactatgg aaaggaagtg gacctctacg ctttggggct     1320

aattcttgct gaacttcttc atgtatgtga cactgctttt gaaacatcaa agtttttcac     1380

agacctacgg gatggcatca tctcagatat atttgataaa aaagaaaaaa ctcttctaca     1440

gaaattactc tcaaagaaac ctgaggatcg acctaacaca tctgaaatac taaggacctt     1500

gactgtgtgg aagaaaagcc cagagaaaaa tgaacgacac acatgttaga gcccttctga     1560

aaaagtatcc tgcttctgat atgcagtttt ccttaaatta tctaaaatct gctagggaat     1620

atcaatagat atttaccttt tattttaatg tttcctttaa ttttttacta tttttactaa     1680

tctttctgca gaaacagaaa ggttttcttc tttttgcttc aaaaacattc ttacatttta     1740

ctttttcctg gctcatctct ttattctttt ttttttttta aagacagagt ctcgctctgt     1800

tgcccaggct ggagtgcaat gacacagtct tggctcactg caacttctgc ctcttgggtt     1860

caagtgattc tcctgcctca gcctcctgag tagctggatt acaggcatgt gccacccacc     1920

caactaattt ttgtgttttt aataaagaca gggtttcacc atgttggcca ggctggtctc     1980

aaactcctga cctcaagtaa tccacctgcc tcggcctccc aaagtgctgg gattacaggg     2040

atgagccacc gcgcccagcc tcatctcttt gttctaaaga tggaaaaacc acccccaaat     2100

tttcttttta tactattaat gaatcaatca attcatatct atttattaaa tttctaccgc     2160

ttttaggcca aaaaaatgta agatcgttct ctgcctcaca tagcttacaa gccagctgga     2220

gaaatatggt actcattaaa aaaaaaaaaa aaagtgatgt acaaccactt cggaaaacaa     2280

tttggcatta tctagtaaag ttgaatccat gtatacccac atagctatca attctattcc     2340

tacatacgtg cttacaagaa tgtccataaa accctgttta taatagccaa aagaacaggg     2400

aacaaccata atgcacatca aaagaagaat ggattaaaaa aattatattc acacacagga     2460

gtactatata gtattgaaaa caattgaagt acagctaaat gtaataacgt aacacaatac     2520

aactctcaga aacataatgt taagcgaaca aagcaggttt tcagaaaata tatgcagaat     2580

aattccattt atataaagtt ccagagcatg caaaactaaa tcattttgta taaaaaaccc     2640

aacaaatgtg atgagacaat aatgggaagg aagggaatga gaaatattaa attctggatg     2700

gtggttatct ttgagggagg ggaatgatgt gattggggaa atggactttc aaaggtaatg     2760

gtaacttcct taagctggat ggtaggtcca ctagtgtttg ctgcatagtt atacctttta     2820

tcttaaatac attttgtatc tattgtaaca accactttaa agacaaccgt gctgtaaggc     2880

agtagctaaa aacagaaaat agtccatcgg gaagggtaag atggctttct gctgagcaca     2940

gggctagaag tgacagccca gtgggccttc caactatatg ccagggtgtt agatgagtag     3000

agaggagacc acccaggaag tctggacaag gggtctggca tgagctctgg agaagatata     3060

tttgaggaac atggggtatg ctagtttgtt gtcctgaatt gctgtagaga agataattta     3120

aattgcatct tagaagacga ccctgagggt gaatttcaac ttagggcaat tgttttagtt     3180

tgtttcttat tggtttaaat ggatacttga agctggataa tttataagga aaagagattt     3240

atatgactta cagttctgca ggctgtacaa gaaacatggc accagcatct gcttcttccc     3300

cggctgcttc cactcatggt ggaaggtgaa ggggagccgg atgtgcagag atcatatggc     3360

aagagaggaa gcaagagagc gagggagaag gtgccaggct ctttttaaat aaccggctct     3420

tgagggaact aatagattga gaactccttg cttctcctcc ccagcacacc ccacccccag     3480

ggacggcatt aatgtattca tgaggggtct tcccccatga cccaaacacc tcccatcagg     3540

ccccacctcc aacactggga tcaaatttca acatgagatt ttgggggaca aacatgcaaa     3600

ctatagcagc aaccagctac cattctaaaa ctgccatatg attttaggat ttttaaaaag     3660

ggccaaattt aggttaagca aaaaaaaaaa aaaaaaa                              3697


<210>  11
<211>  4361
<212>  DNA
<213>  Homo sapiens

<400>  11
agcagacgag ggcttgtgcg agagggggcc gggcggctgc agggaaggcg gagtccaagg       60

ggaaaacgaa actgagaacc agctctcccg aagccgcggg tctccggccg gcggcggcgg      120

cggcggcggc ggcggcgcag tttgctcata ctttgtgact tgcggtcaca gtggcattca      180

gctccacact tggtagaacc acaggcacga caagcataga aacatcctaa acaatcttca      240

tcgaggcatc gaggtccatc ccaataaaaa tcaggagacc ctggctatca tagaccttag      300

tcttcgctgg tatcactcgt ctgtctgaac cagcggttgc atttttttaa gccttctttt      360

ttctctttta ccagtttctg gagcaaattc agtttgcctt cctggatttg taaattgtaa      420

tgacctcaaa actttagcag ttcttccatc tgactcaggt ttgcttctct ggcggtcttc      480

agaatcaaca tccacacttc cgtgattatc tgcgtgcatt ttggacaaag cttccaacca      540

ggatacggga agaagaaatg gctggtgatc tttcagcagg tttcttcatg gaggaactta      600

atacataccg tcagaagcag ggagtagtac ttaaatatca agaactgcct aattcaggac      660

ctccacatga taggaggttt acatttcaag ttataataga tggaagagaa tttccagaag      720

gtgaaggtag atcaaagaag gaagcaaaaa atgccgcagc caaattagct gttgagatac      780

ttaataagga aaagaaggca gttagtcctt tattattgac aacaacgaat tcttcagaag      840

gattatccat ggggaattac ataggcctta tcaatagaat tgcccagaag aaaagactaa      900

ctgtaaatta tgaacagtgt gcatcggggg tgcatgggcc agaaggattt cattataaat      960

gcaaaatggg acagaaagaa tatagtattg gtacaggttc tactaaacag gaagcaaaac     1020

aattggccgc taaacttgca tatcttcaga tattatcaga agaaacctca gtgaaatctg     1080

actacctgtc ctctggttct tttgctacta cgtgtgagtc ccaaagcaac tctttagtga     1140

ccagcacact cgcttctgaa tcatcatctg aaggtgactt ctcagcagat acatcagaga     1200

taaattctaa cagtgacagt ttaaacagtt cttcgttgct tatgaatggt ctcagaaata     1260

atcaaaggaa ggcaaaaaga tctttggcac ccagatttga ccttcctgac atgaaagaaa     1320

caaagtatac tgtggacaag aggtttggca tggattttaa agaaatagaa ttaattggct     1380

caggtggatt tggccaagtt ttcaaagcaa aacacagaat tgacggaaag acttacgtta     1440

ttaaacgtgt taaatataat aacgagaagg cggagcgtga agtaaaagca ttggcaaaac     1500

ttgatcatgt aaatattgtt cactacaatg gctgttggga tggatttgat tatgatcctg     1560

agaccagtga tgattctctt gagagcagtg attatgatcc tgagaacagc aaaaatagtt     1620

caaggtcaaa gactaagtgc cttttcatcc aaatggaatt ctgtgataaa gggaccttgg     1680

aacaatggat tgaaaaaaga agaggcgaga aactagacaa agttttggct ttggaactct     1740

ttgaacaaat aacaaaaggg gtggattata tacattcaaa aaaattaatt catagagatc     1800

ttaagccaag taatatattc ttagtagata caaaacaagt aaagattgga gactttggac     1860

ttgtaacatc tctgaaaaat gatggaaagc gaacaaggag taagggaact ttgcgataca     1920

tgagcccaga acagatttct tcgcaagact atggaaagga agtggacctc tacgctttgg     1980

ggctaattct tgctgaactt cttcatgtat gtgacactgc ttttgaaaca tcaaagtttt     2040

tcacagacct acgggatggc atcatctcag atatatttga taaaaaagaa aaaactcttc     2100

tacagaaatt actctcaaag aaacctgagg atcgacctaa cacatctgaa atactaagga     2160

ccttgactgt gtggaagaaa agcccagaga aaaatgaacg acacacatgt tagagccctt     2220

ctgaaaaagt atcctgcttc tgatatgcag ttttccttaa attatctaaa atctgctagg     2280

gaatatcaat agatatttac cttttatttt aatgtttcct ttaatttttt actattttta     2340

ctaatctttc tgcagaaaca gaaaggtttt cttctttttg cttcaaaaac attcttacat     2400

tttacttttt cctggctcat ctctttattc tttttttttt tttaaagaca gagtctcgct     2460

ctgttgccca ggctggagtg caatgacaca gtcttggctc actgcaactt ctgcctcttg     2520

ggttcaagtg attctcctgc ctcagcctcc tgagtagctg gattacaggc atgtgccacc     2580

cacccaacta atttttgtgt ttttaataaa gacagggttt caccatgttg gccaggctgg     2640

tctcaaactc ctgacctcaa gtaatccacc tgcctcggcc tcccaaagtg ctgggattac     2700

agggatgagc caccgcgccc agcctcatct ctttgttcta aagatggaaa aaccaccccc     2760

aaattttctt tttatactat taatgaatca atcaattcat atctatttat taaatttcta     2820

ccgcttttag gccaaaaaaa tgtaagatcg ttctctgcct cacatagctt acaagccagc     2880

tggagaaata tggtactcat taaaaaaaaa aaaaaaagtg atgtacaacc acttcggaaa     2940

acaatttggc attatctagt aaagttgaat ccatgtatac ccacatagct atcaattcta     3000

ttcctacata cgtgcttaca agaatgtcca taaaaccctg tttataatag ccaaaagaac     3060

agggaacaac cataatgcac atcaaaagaa gaatggatta aaaaaattat attcacacac     3120

aggagtacta tatagtattg aaaacaattg aagtacagct aaatgtaata acgtaacaca     3180

atacaactct cagaaacata atgttaagcg aacaaagcag gttttcagaa aatatatgca     3240

gaataattcc atttatataa agttccagag catgcaaaac taaatcattt tgtataaaaa     3300

acccaacaaa tgtgatgaga caataatggg aaggaaggga atgagaaata ttaaattctg     3360

gatggtggtt atctttgagg gaggggaatg atgtgattgg ggaaatggac tttcaaaggt     3420

aatggtaact tccttaagct ggatggtagg tccactagtg tttgctgcat agttatacct     3480

tttatcttaa atacattttg tatctattgt aacaaccact ttaaagacaa ccgtgctgta     3540

aggcagtagc taaaaacaga aaatagtcca tcgggaaggg taagatggct ttctgctgag     3600

cacagggcta gaagtgacag cccagtgggc cttccaacta tatgccaggg tgttagatga     3660

gtagagagga gaccacccag gaagtctgga caaggggtct ggcatgagct ctggagaaga     3720

tatatttgag gaacatgggg tatgctagtt tgttgtcctg aattgctgta gagaagataa     3780

tttaaattgc atcttagaag acgaccctga gggtgaattt caacttaggg caattgtttt     3840

agtttgtttc ttattggttt aaatggatac ttgaagctgg ataatttata aggaaaagag     3900

atttatatga cttacagttc tgcaggctgt acaagaaaca tggcaccagc atctgcttct     3960

tccccggctg cttccactca tggtggaagg tgaaggggag ccggatgtgc agagatcata     4020

tggcaagaga ggaagcaaga gagcgaggga gaaggtgcca ggctcttttt aaataaccgg     4080

ctcttgaggg aactaataga ttgagaactc cttgcttctc ctccccagca caccccaccc     4140

ccagggacgg cattaatgta ttcatgaggg gtcttccccc atgacccaaa cacctcccat     4200

caggccccac ctccaacact gggatcaaat ttcaacatga gattttgggg gacaaacatg     4260

caaactatag cagcaaccag ctaccattct aaaactgcca tatgatttta ggatttttaa     4320

aaagggccaa atttaggtta agcaaaaaaa aaaaaaaaaa a                         4361


<210>  12
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
            260                 265                 270         


Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
        275                 280                 285             


Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
    290                 295                 300                 


Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
305                 310                 315                 320 


Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                325                 330                 335     


Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
            340                 345                 350         


Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
        355                 360                 365             


Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
    370                 375                 380                 


Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
385                 390                 395                 400 


Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                405                 410                 415     


Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
            420                 425                 430         


Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
        435                 440                 445             


Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
    450                 455                 460                 


Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
465                 470                 475                 480 


Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                485                 490                 495     


Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
            500                 505                 510         


Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
        515                 520                 525             


Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
    530                 535                 540                 


Lys Asn Glu Arg His Thr Cys 
545                 550     


<210>  13
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Lys Ala Glu Arg Glu Val Lys Ala Leu Ala 
            260                 265                 270         


Lys Leu Asp His Val Asn Ile Val His Tyr Asn Gly Cys Trp Asp Gly 
        275                 280                 285             


Phe Asp Tyr Asp Pro Glu Thr Ser Asp Asp Ser Leu Glu Ser Ser Asp 
    290                 295                 300                 


Tyr Asp Pro Glu Asn Ser Lys Asn Ser Ser Arg Ser Lys Thr Lys Cys 
305                 310                 315                 320 


Leu Phe Ile Gln Met Glu Phe Cys Asp Lys Gly Thr Leu Glu Gln Trp 
                325                 330                 335     


Ile Glu Lys Arg Arg Gly Glu Lys Leu Asp Lys Val Leu Ala Leu Glu 
            340                 345                 350         


Leu Phe Glu Gln Ile Thr Lys Gly Val Asp Tyr Ile His Ser Lys Lys 
        355                 360                 365             


Leu Ile His Arg Asp Leu Lys Pro Ser Asn Ile Phe Leu Val Asp Thr 
    370                 375                 380                 


Lys Gln Val Lys Ile Gly Asp Phe Gly Leu Val Thr Ser Leu Lys Asn 
385                 390                 395                 400 


Asp Gly Lys Arg Thr Arg Ser Lys Gly Thr Leu Arg Tyr Met Ser Pro 
                405                 410                 415     


Glu Gln Ile Ser Ser Gln Asp Tyr Gly Lys Glu Val Asp Leu Tyr Ala 
            420                 425                 430         


Leu Gly Leu Ile Leu Ala Glu Leu Leu His Val Cys Asp Thr Ala Phe 
        435                 440                 445             


Glu Thr Ser Lys Phe Phe Thr Asp Leu Arg Asp Gly Ile Ile Ser Asp 
    450                 455                 460                 


Ile Phe Asp Lys Lys Glu Lys Thr Leu Leu Gln Lys Leu Leu Ser Lys 
465                 470                 475                 480 


Lys Pro Glu Asp Arg Pro Asn Thr Ser Glu Ile Leu Arg Thr Leu Thr 
                485                 490                 495     


Val Trp Lys Lys Ser Pro Glu Lys Asn Glu Arg His Thr Cys 
            500                 505                 510 


<210>  14
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
            260                 265                 270         


Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
        275                 280                 285             


Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
    290                 295                 300                 


Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
305                 310                 315                 320 


Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                325                 330                 335     


Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
            340                 345                 350         


Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
        355                 360                 365             


Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
    370                 375                 380                 


Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
385                 390                 395                 400 


Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                405                 410                 415     


Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
            420                 425                 430         


Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
        435                 440                 445             


Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
    450                 455                 460                 


Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
465                 470                 475                 480 


Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                485                 490                 495     


Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
            500                 505                 510         


Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
        515                 520                 525             


Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
    530                 535                 540                 


Lys Asn Glu Arg His Thr Cys 
545                 550     


<210>  15
<211>  3520
<212>  DNA
<213>  Homo sapiens

<400>  15
tcagtagctg aggctgcggt tccccgacgc cacgcagctg cgcgcagctg gttcccgctc       60

tgcagcgcaa cgcctgaggc agtgggcgcg ctcagtcccg ggaccaggcg ttctctcctc      120

tcgcctctgg gcctgggacc ccgcaaagcg gcgatggagc ggaggtcgcg gaggaagtcg      180

cggcgcaacg ggcgctcgac cgcgggcaag gccgccgcga cccagcccgc gaagtctccg      240

ggcgcacagc tctggctctt tcccagcgcc gcgggcctcc accgcgcgct gctccggagg      300

gtggaggtga cgcgccaact ctgctgctcg ccggggcgcc tcgcggtctt ggaacgcggc      360

ggggcgggcg tccaggttca ccagctgctc gccgggagcg gcggcgcccg gacgccgaaa      420

tgcattaaat taggaaaaaa catgaagata cattccgtgg accaaggagc agagcacatg      480

ctgattctct catcagatgg aaaaccattt gagtatgaca actatagcat gaaacatcta      540

aggtttgaaa gcattttaca agaaaaaaaa ataattcaga tcacatgtgg agattaccat      600

tctcttgcac tctcaaaagg tggtgagctt tttgcctggg gacagaacct gcatgggcag      660

cttggagttg gaaggaaatt tccctcaacc accacaccac agattgtgga gcacctcgca      720

ggagtaccct tggctcagat ttctgccgga gaagcccaca gcatggcctt atccatgtct      780

ggcaacattt attcatgggg aaaaaatgaa tgtggacaac taggcctggg ccacactgag      840

agtaaagatg atccatccct tattgaagga ctagacaatc agaaagttga atttgtcgct      900

tgtggtggct ctcacagtgc cctactcaca caggatgggc tgctgtttac tttcggtgct      960

ggaaaacatg ggcaacttgg tcataattca acacagaatg agctaagacc ctgtttggtg     1020

gctgagcttg ttgggtatag agtgactcag atagcatgtg gaaggtggca cacacttgcc     1080

tatgtttctg atttgggaaa ggtcttttcc tttggttctg gaaaagatgg acaactggga     1140

aatggtggaa cacgtgacca gctgatgccg cttccagtga aagtatcatc aagtgaagaa     1200

ctcaaacttg aaagccatac ctcagaaaag gagttaataa tgattgctgg agggaatcaa     1260

agcattttgc tctggataaa gaaagagaat tcatatgtta atctgaagag gacaattcct     1320

actctgaatg aagggactgt aaagagatgg attgctgatg tggagactaa acggtggcag     1380

agcacaaaaa gggaaatcca agagatattt tcatctcctg cttgtctaac tggaagtttt     1440

ttaaggaaaa gaagaactac agaaatgatg cctgtttatt tggacttaaa taaagcaaga     1500

aacatcttca aggagttaac ccaaaaggac tggattacta acatgataac cacctgcctc     1560

aaagataatc tgctcaaaag acttccattt cattctccac cccaagaagc tttagaaatt     1620

ttcttccttc tcccagaatg tcctatgatg catatttcca acaactggga gagccttgtg     1680

gttccatttg caaaggttgt ttgtaaaatg agtgaccagt cttcactggt tctggaagag     1740

tattgggcaa ctctgcaaga atccactttc agcaaactgg tccagatgtt taaaacagcc     1800

gtcatatgcc agttggatta ctgggatgaa agtgctgagg agaatggtaa tgttcaagct     1860

ctcctagaaa tgttgaagaa gctgcacagg gtaaaccagg tgaaatgtca actacctgaa     1920

agtattttcc aagtagacga actcttgcac cgtctcaatt tttttgtaga agtatgcaga     1980

aggtacttgt ggaaaatgac tgtggacgct tcagaaaatg tacaatgctg cgtcatattc     2040

agtcactttc catttatctt taataatctg tcgaaaatta aactactaca tacagacaca     2100

cttttaaaaa tagagagtaa aaaacataaa gcttatctta ggtcggcagc aattgaggaa     2160

gaaagagagt ctgaattcgc tttgaggccc acgtttgatc taacagtcag aaggaatcac     2220

ttgattgagg atgttttgaa tcagctaagt caatttgaga atgaagacct gaggaaagag     2280

ttatgggttt catttagtgg agaaattggg tatgacctcg gaggagtcaa gaaagagttc     2340

ttctactgtc tgtttgcaga gatgatccag ccggaatatg ggatgttcat gtatcctgaa     2400

ggggcttcct gcatgtggtt tcctgtcaag cctaaatttg agaagaaaag atacttcttt     2460

tttggggttc tatgtggact ttccctgttc aattgcaatg ttgccaacct tcctttccca     2520

ctggcactgt ttaagaaact tttggaccaa atgccatcat tggaagactt gaaagaactc     2580

agtcctgatt tgggaaagaa tttgcaaaca cttctggatg atgaaggtga taactttgag     2640

gaagtatttt acatccattt taatgtgcac tgggacagaa acgacacaaa cttaattcct     2700

aatggaagta gcataactgt caaccagact aacaagagag actatgtttc taagtatatc     2760

aattacattt tcaacgactc tgtaaaggcg gtttatgaag aatttcggag aggattttat     2820

aaaatgtgcg acgaagacat tatcaaatta ttccaccccg aagaactgaa ggatgtgatt     2880

gttggaaata cagattatga ttggaaaaca tttgaaaaga atgcacgtta tgaaccagga     2940

tataacagtt cacatcccac catagtgatg ttttggaagg ctttccacaa attgactctg     3000

gaagaaaaga aaaaattcct tgtatttctt acaggaactg acagactaca aatgaaagat     3060

ttaaataata tgaaaataac attttgctgt cctgaaagtt ggaatgaaag agaccctata     3120

agagcactga catgtttcag tgtcctcttc ctccctaaat attctacaat ggaaacagtt     3180

gaagaagcgc ttcaagaagc catcaacaac aacagaggat ttggctgacc agcttgcttg     3240

tccaacagcc ttattttgtt gttgttatcg ttgttgttgt tgttgttgtt gttgtttctc     3300

tactttgttt tgttttaggc ttttagcagc ctgaagccat ggtttttcat ttctgtctct     3360

agtgataagc aggaaagagg gatgaagaag agggtttact ggccggttag aacccgtgac     3420

tgtattctct cccttggata cccctatgcc tacatcatat tccttacctc ttttgggaaa     3480

tatttttcaa aaataaaata accgaaaaat taacataaaa                           3520


<210>  16
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Arg Arg Ser Arg Arg Lys Ser Arg Arg Asn Gly Arg Ser Thr 
1               5                   10                  15      


Ala Gly Lys Ala Ala Ala Thr Gln Pro Ala Lys Ser Pro Gly Ala Gln 
            20                  25                  30          


Leu Trp Leu Phe Pro Ser Ala Ala Gly Leu His Arg Ala Leu Leu Arg 
        35                  40                  45              


Arg Val Glu Val Thr Arg Gln Leu Cys Cys Ser Pro Gly Arg Leu Ala 
    50                  55                  60                  


Val Leu Glu Arg Gly Gly Ala Gly Val Gln Val His Gln Leu Leu Ala 
65                  70                  75                  80  


Gly Ser Gly Gly Ala Arg Thr Pro Lys Cys Ile Lys Leu Gly Lys Asn 
                85                  90                  95      


Met Lys Ile His Ser Val Asp Gln Gly Ala Glu His Met Leu Ile Leu 
            100                 105                 110         


Ser Ser Asp Gly Lys Pro Phe Glu Tyr Asp Asn Tyr Ser Met Lys His 
        115                 120                 125             


Leu Arg Phe Glu Ser Ile Leu Gln Glu Lys Lys Ile Ile Gln Ile Thr 
    130                 135                 140                 


Cys Gly Asp Tyr His Ser Leu Ala Leu Ser Lys Gly Gly Glu Leu Phe 
145                 150                 155                 160 


Ala Trp Gly Gln Asn Leu His Gly Gln Leu Gly Val Gly Arg Lys Phe 
                165                 170                 175     


Pro Ser Thr Thr Thr Pro Gln Ile Val Glu His Leu Ala Gly Val Pro 
            180                 185                 190         


Leu Ala Gln Ile Ser Ala Gly Glu Ala His Ser Met Ala Leu Ser Met 
        195                 200                 205             


Ser Gly Asn Ile Tyr Ser Trp Gly Lys Asn Glu Cys Gly Gln Leu Gly 
    210                 215                 220                 


Leu Gly His Thr Glu Ser Lys Asp Asp Pro Ser Leu Ile Glu Gly Leu 
225                 230                 235                 240 


Asp Asn Gln Lys Val Glu Phe Val Ala Cys Gly Gly Ser His Ser Ala 
                245                 250                 255     


Leu Leu Thr Gln Asp Gly Leu Leu Phe Thr Phe Gly Ala Gly Lys His 
            260                 265                 270         


Gly Gln Leu Gly His Asn Ser Thr Gln Asn Glu Leu Arg Pro Cys Leu 
        275                 280                 285             


Val Ala Glu Leu Val Gly Tyr Arg Val Thr Gln Ile Ala Cys Gly Arg 
    290                 295                 300                 


Trp His Thr Leu Ala Tyr Val Ser Asp Leu Gly Lys Val Phe Ser Phe 
305                 310                 315                 320 


Gly Ser Gly Lys Asp Gly Gln Leu Gly Asn Gly Gly Thr Arg Asp Gln 
                325                 330                 335     


Leu Met Pro Leu Pro Val Lys Val Ser Ser Ser Glu Glu Leu Lys Leu 
            340                 345                 350         


Glu Ser His Thr Ser Glu Lys Glu Leu Ile Met Ile Ala Gly Gly Asn 
        355                 360                 365             


Gln Ser Ile Leu Leu Trp Ile Lys Lys Glu Asn Ser Tyr Val Asn Leu 
    370                 375                 380                 


Lys Arg Thr Ile Pro Thr Leu Asn Glu Gly Thr Val Lys Arg Trp Ile 
385                 390                 395                 400 


Ala Asp Val Glu Thr Lys Arg Trp Gln Ser Thr Lys Arg Glu Ile Gln 
                405                 410                 415     


Glu Ile Phe Ser Ser Pro Ala Cys Leu Thr Gly Ser Phe Leu Arg Lys 
            420                 425                 430         


Arg Arg Thr Thr Glu Met Met Pro Val Tyr Leu Asp Leu Asn Lys Ala 
        435                 440                 445             


Arg Asn Ile Phe Lys Glu Leu Thr Gln Lys Asp Trp Ile Thr Asn Met 
    450                 455                 460                 


Ile Thr Thr Cys Leu Lys Asp Asn Leu Leu Lys Arg Leu Pro Phe His 
465                 470                 475                 480 


Ser Pro Pro Gln Glu Ala Leu Glu Ile Phe Phe Leu Leu Pro Glu Cys 
                485                 490                 495     


Pro Met Met His Ile Ser Asn Asn Trp Glu Ser Leu Val Val Pro Phe 
            500                 505                 510         


Ala Lys Val Val Cys Lys Met Ser Asp Gln Ser Ser Leu Val Leu Glu 
        515                 520                 525             


Glu Tyr Trp Ala Thr Leu Gln Glu Ser Thr Phe Ser Lys Leu Val Gln 
    530                 535                 540                 


Met Phe Lys Thr Ala Val Ile Cys Gln Leu Asp Tyr Trp Asp Glu Ser 
545                 550                 555                 560 


Ala Glu Glu Asn Gly Asn Val Gln Ala Leu Leu Glu Met Leu Lys Lys 
                565                 570                 575     


Leu His Arg Val Asn Gln Val Lys Cys Gln Leu Pro Glu Ser Ile Phe 
            580                 585                 590         


Gln Val Asp Glu Leu Leu His Arg Leu Asn Phe Phe Val Glu Val Cys 
        595                 600                 605             


Arg Arg Tyr Leu Trp Lys Met Thr Val Asp Ala Ser Glu Asn Val Gln 
    610                 615                 620                 


Cys Cys Val Ile Phe Ser His Phe Pro Phe Ile Phe Asn Asn Leu Ser 
625                 630                 635                 640 


Lys Ile Lys Leu Leu His Thr Asp Thr Leu Leu Lys Ile Glu Ser Lys 
                645                 650                 655     


Lys His Lys Ala Tyr Leu Arg Ser Ala Ala Ile Glu Glu Glu Arg Glu 
            660                 665                 670         


Ser Glu Phe Ala Leu Arg Pro Thr Phe Asp Leu Thr Val Arg Arg Asn 
        675                 680                 685             


His Leu Ile Glu Asp Val Leu Asn Gln Leu Ser Gln Phe Glu Asn Glu 
    690                 695                 700                 


Asp Leu Arg Lys Glu Leu Trp Val Ser Phe Ser Gly Glu Ile Gly Tyr 
705                 710                 715                 720 


Asp Leu Gly Gly Val Lys Lys Glu Phe Phe Tyr Cys Leu Phe Ala Glu 
                725                 730                 735     


Met Ile Gln Pro Glu Tyr Gly Met Phe Met Tyr Pro Glu Gly Ala Ser 
            740                 745                 750         


Cys Met Trp Phe Pro Val Lys Pro Lys Phe Glu Lys Lys Arg Tyr Phe 
        755                 760                 765             


Phe Phe Gly Val Leu Cys Gly Leu Ser Leu Phe Asn Cys Asn Val Ala 
    770                 775                 780                 


Asn Leu Pro Phe Pro Leu Ala Leu Phe Lys Lys Leu Leu Asp Gln Met 
785                 790                 795                 800 


Pro Ser Leu Glu Asp Leu Lys Glu Leu Ser Pro Asp Leu Gly Lys Asn 
                805                 810                 815     


Leu Gln Thr Leu Leu Asp Asp Glu Gly Asp Asn Phe Glu Glu Val Phe 
            820                 825                 830         


Tyr Ile His Phe Asn Val His Trp Asp Arg Asn Asp Thr Asn Leu Ile 
        835                 840                 845             


Pro Asn Gly Ser Ser Ile Thr Val Asn Gln Thr Asn Lys Arg Asp Tyr 
    850                 855                 860                 


Val Ser Lys Tyr Ile Asn Tyr Ile Phe Asn Asp Ser Val Lys Ala Val 
865                 870                 875                 880 


Tyr Glu Glu Phe Arg Arg Gly Phe Tyr Lys Met Cys Asp Glu Asp Ile 
                885                 890                 895     


Ile Lys Leu Phe His Pro Glu Glu Leu Lys Asp Val Ile Val Gly Asn 
            900                 905                 910         


Thr Asp Tyr Asp Trp Lys Thr Phe Glu Lys Asn Ala Arg Tyr Glu Pro 
        915                 920                 925             


Gly Tyr Asn Ser Ser His Pro Thr Ile Val Met Phe Trp Lys Ala Phe 
    930                 935                 940                 


His Lys Leu Thr Leu Glu Glu Lys Lys Lys Phe Leu Val Phe Leu Thr 
945                 950                 955                 960 


Gly Thr Asp Arg Leu Gln Met Lys Asp Leu Asn Asn Met Lys Ile Thr 
                965                 970                 975     


Phe Cys Cys Pro Glu Ser Trp Asn Glu Arg Asp Pro Ile Arg Ala Leu 
            980                 985                 990         


Thr Cys Phe Ser Val Leu Phe Leu  Pro Lys Tyr Ser Thr  Met Glu Thr 
        995                 1000                 1005             


Val Glu  Glu Ala Leu Gln Glu  Ala Ile Asn Asn Asn  Arg Gly Phe 
    1010                 1015                 1020             


Gly 
    


<210>  17
<211>  3512
<212>  DNA
<213>  Homo sapiens

<400>  17
aactcagctg agtgttagtc aaagaaggtg tgtcctgctc cccaatgaca ggttgctcag       60

agactgctga tttccatccc tatataaaga gagtccctgg catacagaga ctgctctgct      120

ccaggcatct gccacaatgt gggtgcttac acctgctgct tttgctggga agctcttgag      180

tgtgttcagg caacctctga gctctctgtg gaggagcctg gtcccgctgt tctgctggct      240

gagggcaacc ttctggctgc tagctaccaa gaggagaaag cagcagctgg tcctgagagg      300

gccagatgag accaaagagg aggaagagga ccctcctctg cccaccaccc caaccagcgt      360

caactatcac ttcactcgcc agtgcaacta caaatgcggc ttctgtttcc acacagccaa      420

aacatccttt gtgctgcccc ttgaggaagc aaagagagga ttgcttttgc ttaaggaagc      480

tggtatggag aagatcaact tttcaggtgg agagccattt cttcaagacc ggggagaata      540

cctgggcaag ttggtgaggt tctgcaaagt agagttgcgg ctgcccagcg tgagcatcgt      600

gagcaatgga agcctgatcc gggagaggtg gttccagaat tatggtgagt atttggacat      660

tctcgctatc tcctgtgaca gctttgacga ggaagtcaat gtccttattg gccgtggcca      720

aggaaagaag aaccatgtgg aaaaccttca aaagctgagg aggtggtgta gggattatag      780

agtcgctttc aagataaatt ctgtcattaa tcgtttcaac gtggaagagg acatgacgga      840

acagatcaaa gcactaaacc ctgtccgctg gaaagtgttc cagtgcctct taattgaggg      900

tgagaattgt ggagaagatg ctctaagaga agcagaaaga tttgttattg gtgatgaaga      960

atttgaaaga ttcttggagc gccacaaaga agtgtcctgc ttggtgcctg aatctaacca     1020

gaagatgaaa gactcctacc ttattctgga tgaatatatg cgctttctga actgtagaaa     1080

gggacggaag gacccttcca agtccatcct ggatgttggt gtagaagaag ctataaaatt     1140

cagtggattt gatgaaaaga tgtttctgaa gcgaggagga aaatacatat ggagtaaggc     1200

tgatctgaag ctggattggt agagcggaaa gtggaacgag acttcaacac accagtggga     1260

aaactcctag agtaactgcc attgtctgca atactatccc gttggtattt cccagtggct     1320

gaaaacctga ttttctgctg cacgtggcat ctgattacct gtggtcactg aacacacgaa     1380

taacttggat agcaaatcct gagacaatgg aaaaccatta actttacttc attggcttat     1440

aaccttgttg ttattgaaac agcacttctg tttttgagtt tgttttagct aaaaagaagg     1500

aatacacaca ggaataatga ccccaaaaat gcttagataa ggcccctata cacaggacct     1560

gacatttagc tcaatgatgc gtttgtaaga aataagctct agtgatatct gtgggggcaa     1620

aatttaattt ggatttgatt ttttaaaaca atgtttactg cgatttctat atttccattt     1680

tgaaactatt tcttgttcca ggtttgttca tttgacagag tcagtatttt ttgccaaata     1740

tccagataac cagttttcac atctgagaca ttacaaagta tctgcctcaa ttatttctgc     1800

tggttataat gctttttttt ttttgccttt atgccattgc agtcttgtac tttttactgt     1860

gatgtacaga aatagtcaac agatgtttcc aagaacatat gatatgataa tcctaccaat     1920

tttcaagaag tctctagaaa gagataacac atggaaagac ggtgtggtgc agcccagccc     1980

acggtggctg ttccatgaat gctggctacc tatgtgtgtg gtacctgttg tgtccctttc     2040

tcttcaaaga tcctgagcaa aacaaagata cgctttccat ttgatgatgg agttgacatg     2100

gaggcagtgc ttgcattgct ttgttcgcct atcatctggc cacatgaggc tgtcaagcaa     2160

aagaatagga gtgtagttga gtagctggtt ggccctacat ctctgagaag tgacggcaca     2220

ctgggttggc ataagatatc ctaaaatcac gctggaacct tgggcaagga agaatgtgag     2280

caagagtaga gagagtgcct ggatttcatg tcagtgaagc caagtcacca tatcatattt     2340

ttgaatgaac tctgagtcag ttgaaatagg gtaccatcta ggtcagttta agaagagtca     2400

gctcagagaa agcaagcata agggaaaatg tcacgtaaac tagatcaggg aacaaaatcc     2460

tctccttgtg gaaatatccc atgcagtttg ttgatacaac ttagtatctt attgcctaaa     2520

aaaaaatttc ttatcattgt ttcaaaaaag caaaatcatg gaaaattttt gttgtccagg     2580

caaataaaag gtcattttaa tttagctgca atttcagtgt tcctcactag gtggcattta     2640

aatgtcgcct gatgtcatta agcaccatcc aaaaagtctg cttcataatc tattttcaag     2700

acttggtgat tctgaaagtt ttggtttttg tgactttgtt tctcaggaaa aaaaatattc     2760

ctacttaaat tttaagtcta taattcaatt taaatatgtg tgtgtctcat ccaggatagg     2820

ataggttgtc ttctattttc cattttacct atttactttt tttgtaagaa aagagaaaaa     2880

tgaattctaa agatgttccc catgggtttt gattgtgtct aagctatgat gaccttcata     2940

taatcagcat aaacataaaa caaatttttt acttaacatg agtgcacttt actaatcctc     3000

atggcacagt ggctcacgcc tgtaatccca gcacttggga ggacaatgtg ggtggatcac     3060

gaggtcagga gttcgagaac agcctggcca acatggtgaa accccgtctc cactaaaaat     3120

acaaaaatta gccaggcatg gtggcgtaca cttgtaattc cagctactca agaggctgag     3180

gcaggaggat tgcttgaacc ctgaaggcag aggttacaga gccaagatag cgccactgca     3240

ctccagcctg gatgacagag caagactccg tctcaaaaaa aaaaaaaaaa aaaagcaaga     3300

gagttcaact aagaaaggtc acatatgtga aagcccaagg acactgtttg atatacagca     3360

ggtattcaat cagtgttatt tgaaaccaaa tctgaatttg aagtttgaat cttctgagtt     3420

ggaatgaatt tttttctagc tgagggaaac tgtatttttc tttccccaaa gaggaatgta     3480

atgtaaagtg aaataaaact ataagctatg tt                                   3512


<210>  18
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  19
<211>  2983
<212>  DNA
<213>  Homo sapiens

<400>  19
gttcgggccc gagaacctgc gtctcccgcg agttcccgcg aggcaagtgc tgcaggtgcg       60

gggccaggag ctaggtttcg tttctgcgcc cggagccgcc ctcagcacag ggtctgtgag      120

tttcatttct tcgcggcgcg gggcggggct gggcgcgggg tgaaagaggc gaagcgagag      180

cggaggccgc actccagcac tgcgcaggga ccgccttgga ccgcagttgc cggccaggaa      240

tcccagtgtc acggtggaca cgcctccctc gcgcccttgc cgcccacctg ctcacccagc      300

tcaggggctt tggaattctg tggccacact gcgaggagat cggttctggg tcggaggcta      360

caggaagact cccactccct gaaatctgga gtgaagaacg ccgccatcca gccaccattc      420

caaggaggtg caggagaaca gctctgtgat accatttaac ttgttgacat tacttttatt      480

tgaaggaacg tatattagag cttactttgc aaagaaggaa gatggttgtt tccgaagtgg      540

acatcgcaaa agctgatcca gctgctgcat cccaccctct attactgaat ggagatgcta      600

ctgtggccca gaaaaatcca ggctcggtgg ctgagaacaa cctgtgcagc cagtatgagg      660

agaaggtgcg cccctgcatc gacctcattg actccctgcg ggctctaggt gtggagcagg      720

acctggccct gccagccatc gccgtcatcg gggaccagag ctcgggcaag agctccgtgt      780

tggaggcact gtcaggagtt gcccttccca gaggcagcgg gatcgtgacc agatgcccgc      840

tggtgctgaa actgaagaaa cttgtgaacg aagataagtg gagaggcaag gtcagttacc      900

aggactacga gattgagatt tcggatgctt cagaggtaga aaaggaaatt aataaagccc      960

agaatgccat cgccggggaa ggaatgggaa tcagtcatga gctaatcacc ctggagatca     1020

gctcccgaga tgtcccggat ctgactctaa tagaccttcc tggcataacc agagtggctg     1080

tgggcaatca gcctgctgac attgggtata agatcaagac actcatcaag aagtacatcc     1140

agaggcagga gacaatcagc ctggtggtgg tccccagtaa tgtggacatc gccaccacag     1200

aggctctcag catggcccag gaggtggacc ccgagggaga caggaccatc ggaatcttga     1260

cgaagcctga tctggtggac aaaggaactg aagacaaggt tgtggacgtg gtgcggaacc     1320

tcgtgttcca cctgaagaag ggttacatga ttgtcaagtg ccggggccag caggagatcc     1380

aggaccagct gagcctgtcc gaagccctgc agagagagaa gatcttcttt gagaaccacc     1440

catatttcag ggatctgctg gaggaaggaa aggccacggt tccctgcctg gcagaaaaac     1500

ttaccagcga gctcatcaca catatctgta aatctctgcc cctgttagaa aatcaaatca     1560

aggagactca ccagagaata acagaggagc tacaaaagta tggtgtcgac ataccggaag     1620

acgaaaatga aaaaatgttc ttcctgatag ataaagttaa tgcctttaat caggacatca     1680

ctgctctcat gcaaggagag gaaactgtag gggaggaaga cattcggctg tttaccagac     1740

tccgacacga gttccacaaa tggagtacaa taattgaaaa caattttcaa gaaggccata     1800

aaattttgag tagaaaaatc cagaaatttg aaaatcagta tcgtggtaga gagctgccag     1860

gctttgtgaa ttacaggaca tttgagacaa tcgtgaaaca gcaaatcaag gcactggaag     1920

agccggctgt ggatatgcta cacaccgtga cggatatggt ccggcttgct ttcacagatg     1980

tttcgataaa aaattttgaa gagtttttta acctccacag aaccgccaag tccaaaattg     2040

aagacattag agcagaacaa gagagagaag gtgagaagct gatccgcctc cacttccaga     2100

tggaacagat tgtctactgc caggaccagg tatacagggg tgcattgcag aaggtcagag     2160

agaaggagct ggaagaagaa aagaagaaga aatcctggga ttttggggct ttccagtcca     2220

gctcggcaac agactcttcc atggaggaga tctttcagca cctgatggcc tatcaccagg     2280

aggccagcaa gcgcatctcc agccacatcc ctttgatcat ccagttcttc atgctccaga     2340

cgtacggcca gcagcttcag aaggccatgc tgcagctcct gcaggacaag gacacctaca     2400

gctggctcct gaaggagcgg agcgacacca gcgacaagcg gaagttcctg aaggagcggc     2460

ttgcacggct gacgcaggct cggcgccggc ttgcccagtt ccccggttaa ccacactctg     2520

tccagccccg tagacgtgca cgcacactgt ctgcccccgt tcccgggtag ccactggact     2580

gacgacttga gtgctcagta gtcagactgg atagtccgtc tctgcttatc cgttagccgt     2640

ggtgatttag caggaagctg tgagagcagt ttggtttcta gcatgaagac agagccccac     2700

cctcagatgc acatgagctg gcgggattga aggatgctgt cttcgtactg ggaaagggat     2760

tttcagccct cagaatcgct ccaccttgca gctctcccct tctctgtatt cctagaaact     2820

gacacatgct gaacatcaca gcttatttcc tcatttttat aatgtccctt cacaaaccca     2880

gtgttttagg agcatgagtg ccgtgtgtgt gcgtcctgtc ggagccctgt ctcctctctc     2940

tgtaataaac tcatttctag cagacaaaaa aaaaaaaaaa aaa                       2983


<210>  20
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Val Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


<210>  21
<211>  2683
<212>  DNA
<213>  Homo sapiens

<400>  21
tttcttcgcg gcgcggggcg gggctgggcg cggggtgaaa gaggcgaagc gagagcggag       60

gccgcactcc agcactgcgc agggaccgga attctgtggc cacactgcga ggagatcggt      120

tctgggtcgg aggctacagg aagactccca ctccctgaaa tctggagtga agaacgccgc      180

catccagcca ccattccaag cttactttgc aaagaaggaa gatggttgtt tccgaagtgg      240

acatcgcaaa agctgatcca gctgctgcat cccaccctct attactgaat ggagatgcta      300

ctgtggccca gaaaaatcca ggctcggtgg ctgagaacaa cctgtgcagc cagtatgagg      360

agaaggtgcg cccctgcatc gacctcattg actccctgcg ggctctaggt gtggagcagg      420

acctggccct gccagccatc gccgtcatcg gggaccagag ctcgggcaag agctccgtgt      480

tggaggcact gtcaggagtt gcccttccca gaggcagcgg gatcgtgacc agatgcccgc      540

tggtgctgaa actgaagaaa cttgtgaacg aagataagtg gagaggcaag gtcagttacc      600

aggactacga gattgagatt tcggatgctt cagaggtaga aaaggaaatt aataaagccc      660

agaatgccat cgccggggaa ggaatgggaa tcagtcatga gctaatcacc ctggagatca      720

gctcccgaga tgtcccggat ctgactctaa tagaccttcc tggcataacc agagtggctg      780

tgggcaatca gcctgctgac attgggtata agatcaagac actcatcaag aagtacatcc      840

agaggcagga gacaatcagc ctggtggtgg tccccagtaa tgtggacatc gccaccacag      900

aggctctcag catggcccag gaggtggacc ccgagggaga caggaccatc ggaatcttga      960

cgaagcctga tctggtggac aaaggaactg aagacaaggt tgtggacgtg gtgcggaacc     1020

tcgtgttcca cctgaagaag ggttacatga ttgtcaagtg ccggggccag caggagatcc     1080

aggaccagct gagcctgtcc gaagccctgc agagagagaa gatcttcttt gagaaccacc     1140

catatttcag ggatctgctg gaggaaggaa aggccacggt tccctgcctg gcagaaaaac     1200

ttaccagcga gctcatcaca catatctgta aatctctgcc cctgttagaa aatcaaatca     1260

aggagactca ccagagaata acagaggagc tacaaaagta tggtgtcgac ataccggaag     1320

acgaaaatga aaaaatgttc ttcctgatag ataaagttaa tgcctttaat caggacatca     1380

ctgctctcat gcaaggagag gaaactgtag gggaggaaga cattcggctg tttaccagac     1440

tccgacacga gttccacaaa tggagtacaa taattgaaaa caattttcaa gaaggccata     1500

aaattttgag tagaaaaatc cagaaatttg aaaatcagta tcgtggtaga gagctgccag     1560

gctttgtgaa ttacaggaca tttgagacaa tcgtgaaaca gcaaatcaag gcactggaag     1620

agccggctgt ggatatgcta cacaccgtga cggatatggt ccggcttgct ttcacagatg     1680

tttcgataaa aaattttgaa gagtttttta acctccacag aaccgccaag tccaaaattg     1740

aagacattag agcagaacaa gagagagaag gtgagaagct gatccgcctc cacttccaga     1800

tggaacagat tgtctactgc caggaccagg tatacagggg tgcattgcag aaggtcagag     1860

agaaggagct ggaagaagaa aagaagaaga aatcctggga ttttggggct ttccagtcca     1920

gctcggcaac agactcttcc atggaggaga tctttcagca cctgatggcc tatcaccagg     1980

aggccagcaa gcgcatctcc agccacatcc ctttgatcat ccagttcttc atgctccaga     2040

cgtacggcca gcagcttcag aaggccatgc tgcagctcct gcaggacaag gacacctaca     2100

gctggctcct gaaggagcgg agcgacacca gcgacaagcg gaagttcctg aaggagcggc     2160

ttgcacggct gacgcaggct cggcgccggc ttgcccagtt ccccggttaa ccacactctg     2220

tccagccccg tagacgtgca cgcacactgt ctgcccccgt tcccgggtag ccactggact     2280

gacgacttga gtgctcagta gtcagactgg atagtccgtc tctgcttatc cgttagccgt     2340

ggtgatttag caggaagctg tgagagcagt ttggtttcta gcatgaagac agagccccac     2400

cctcagatgc acatgagctg gcgggattga aggatgctgt cttcgtactg ggaaagggat     2460

tttcagccct cagaatcgct ccaccttgca gctctcccct tctctgtatt cctagaaact     2520

gacacatgct gaacatcaca gcttatttcc tcatttttat aatgtccctt cacaaaccca     2580

gtgttttagg agcatgagtg ccgtgtgtgt gcgtcctgtc ggagccctgt ctcctctctc     2640

tgtaataaac tcatttctag cagacaaaaa aaaaaaaaaa aaa                       2683


<210>  22
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Val Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


<210>  23
<211>  3409
<212>  DNA
<213>  Homo sapiens

<400>  23
aaattcgcgg tgggggcgga gagcgcaggg agaagtaagc ccagtgcagg atcctgaggc       60

ccgtgtttgc aggaccaggg ccggccttcc gattccccat tcattccaga agcaccgaac      120

cacgctgtgc ccggatccca agtgcagcgg cacccagcgt gggcctgggg ttgccggttg      180

acccggtcct cagcctggta gcagaggcca ggccagtgcc acaaggcacc taagtccacc      240

tgggcctgga gcaggacagg ttgcaaaaga aaatatctcg ggacccccaa actccttatg      300

ctaagggaaa catcgagcct gggaactgag ccatcaacgc tgccattctt tttcccaaac      360

agaaccctgt tgtcagaggt acacccagag caactccaca ccgggtgcat gccacagcaa      420

ctccatctta aataggagct ggtaaaacga ggctgatacc tactgggctg cattcccaga      480

cggcatagcg aggaggtgct gaagagcgca ggtttggaga atgatcacct ggattggaac      540

catagctcta ccaatatgga acccagctcc ttaggcctcg gtcttctcat ggagaacatg      600

gtgtgataat cctactcctc tgggagggtg gctgttaagc cttggaccgc agttgccggc      660

caggaatccc agtgtcacgg tggacacgcc tccctcgcgc ccttgccgcc cacctgctca      720

cccagctcag gggctttgga attctgtggc cacactgcga ggagatcggt tctgggtcgg      780

aggctacagg aagactccca ctccctgaaa tctggagtga agaacgccgc catccagcca      840

ccattccaag gaggtgcagg agaacagctc tgtgatacca tttaacttgt tgacattact      900

tttatttgaa ggaacgtata ttagagctta ctttgcaaag aaggaagatg gttgtttccg      960

aagtggacat cgcaaaagct gatccagctg ctgcatccca ccctctatta ctgaatggag     1020

atgctactgt ggcccagaaa aatccaggct cggtggctga gaacaacctg tgcagccagt     1080

atgaggagaa ggtgcgcccc tgcatcgacc tcattgactc cctgcgggct ctaggtgtgg     1140

agcaggacct ggccctgcca gccatcgccg tcatcgggga ccagagctcg ggcaagagct     1200

ccgtgttgga ggcactgtca ggagttgccc ttcccagagg cagcgggatc gtgaccagat     1260

gcccgctggt gctgaaactg aagaaacttg tgaacgaaga taagtggaga ggcaaggtca     1320

gttaccagga ctacgagatt gagatttcgg atgcttcaga ggtagaaaag gaaattaata     1380

aagcccagaa tgccatcgcc ggggaaggaa tgggaatcag tcatgagcta atcaccctgg     1440

agatcagctc ccgagatgtc ccggatctga ctctaataga ccttcctggc ataaccagag     1500

tggctgtggg caatcagcct gctgacattg ggtataagat caagacactc atcaagaagt     1560

acatccagag gcaggagaca atcagcctgg tggtggtccc cagtaatgtg gacatcgcca     1620

ccacagaggc tctcagcatg gcccaggagg tggaccccga gggagacagg accatcggaa     1680

tcttgacgaa gcctgatctg gtggacaaag gaactgaaga caaggttgtg gacgtggtgc     1740

ggaacctcgt gttccacctg aagaagggtt acatgattgt caagtgccgg ggccagcagg     1800

agatccagga ccagctgagc ctgtccgaag ccctgcagag agagaagatc ttctttgaga     1860

accacccata tttcagggat ctgctggagg aaggaaaggc cacggttccc tgcctggcag     1920

aaaaacttac cagcgagctc atcacacata tctgtaaatc tctgcccctg ttagaaaatc     1980

aaatcaagga gactcaccag agaataacag aggagctaca aaagtatggt gtcgacatac     2040

cggaagacga aaatgaaaaa atgttcttcc tgatagataa agttaatgcc tttaatcagg     2100

acatcactgc tctcatgcaa ggagaggaaa ctgtagggga ggaagacatt cggctgttta     2160

ccagactccg acacgagttc cacaaatgga gtacaataat tgaaaacaat tttcaagaag     2220

gccataaaat tttgagtaga aaaatccaga aatttgaaaa tcagtatcgt ggtagagagc     2280

tgccaggctt tgtgaattac aggacatttg agacaatcgt gaaacagcaa atcaaggcac     2340

tggaagagcc ggctgtggat atgctacaca ccgtgacgga tatggtccgg cttgctttca     2400

cagatgtttc gataaaaaat tttgaagagt tttttaacct ccacagaacc gccaagtcca     2460

aaattgaaga cattagagca gaacaagaga gagaaggtga gaagctgatc cgcctccact     2520

tccagatgga acagattgtc tactgccagg accaggtata caggggtgca ttgcagaagg     2580

tcagagagaa ggagctggaa gaagaaaaga agaagaaatc ctgggatttt ggggctttcc     2640

agtccagctc ggcaacagac tcttccatgg aggagatctt tcagcacctg atggcctatc     2700

accaggaggc cagcaagcgc atctccagcc acatcccttt gatcatccag ttcttcatgc     2760

tccagacgta cggccagcag cttcagaagg ccatgctgca gctcctgcag gacaaggaca     2820

cctacagctg gctcctgaag gagcggagcg acaccagcga caagcggaag ttcctgaagg     2880

agcggcttgc acggctgacg caggctcggc gccggcttgc ccagttcccc ggttaaccac     2940

actctgtcca gccccgtaga cgtgcacgca cactgtctgc ccccgttccc gggtagccac     3000

tggactgacg acttgagtgc tcagtagtca gactggatag tccgtctctg cttatccgtt     3060

agccgtggtg atttagcagg aagctgtgag agcagtttgg tttctagcat gaagacagag     3120

ccccaccctc agatgcacat gagctggcgg gattgaagga tgctgtcttc gtactgggaa     3180

agggattttc agccctcaga atcgctccac cttgcagctc tccccttctc tgtattccta     3240

gaaactgaca catgctgaac atcacagctt atttcctcat ttttataatg tcccttcaca     3300

aacccagtgt tttaggagca tgagtgccgt gtgtgtgcgt cctgtcggag ccctgtctcc     3360

tctctctgta ataaactcat ttctagcaga caaaaaaaaa aaaaaaaaa                 3409


<210>  24
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Val Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


