                         SEQUENCE LISTING

<110>  Fritzinger, David C
       Benjamin, Daniel E
 
<120>  Modulators of Complement Function

<130>  TPC32415

<150>  US 62/238,512
<151>  2015-10-07

<150>  US 15/288,830
<151>  2016-10-07

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1642
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn Ile Leu Arg Leu Glu 
1               5                   10                  15      


Ser Glu Glu Thr Met Val Leu Glu Ala His Asp Ala Gln Gly Asp Val 
            20                  25                  30          


Pro Val Thr Val Thr Val His Asp Phe Pro Gly Lys Lys Leu Val Leu 
        35                  40                  45              


Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr Asn His Met Gly Asn 
    50                  55                  60                  


Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe Lys Ser Glu Lys Gly 
65                  70                  75                  80  


Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe Gly Thr Gln Val Val 
                85                  90                  95      


Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly Tyr Leu Phe Ile Gln 
            100                 105                 110         


Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr Val Leu Tyr Arg Ile 
        115                 120                 125             


Phe Thr Val Asn His Lys Leu Leu Pro Val Gly Arg Thr Val Met Val 
    130                 135                 140                 


Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys Gln Asp Ser Leu Ser 
145                 150                 155                 160 


Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser Trp Asp Ile Pro Glu 
                165                 170                 175     


Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala Tyr Tyr Glu Asn Ser 
            180                 185                 190         


Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val Lys Glu Tyr Val Leu 
        195                 200                 205             


Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu Lys Phe Tyr Tyr Ile 
    210                 215                 220                 


Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr Ala Arg Phe Leu Tyr 
225                 230                 235                 240 


Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile Phe Gly Ile Gln Asp 
                245                 250                 255     


Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu Lys Arg Ile Pro Ile 
            260                 265                 270         


Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg Lys Val Leu Leu Asp 
        275                 280                 285             


Gly Val Gln Asn Leu Arg Ala Glu Asp Leu Val Gly Lys Ser Leu Tyr 
    290                 295                 300                 


Val Ser Ala Thr Val Ile Leu His Ser Gly Ser Asp Met Val Gln Ala 
305                 310                 315                 320 


Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro Tyr Gln Ile His Phe 
                325                 330                 335     


Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met Pro Phe Asp Leu Met 
            340                 345                 350         


Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala Tyr Arg Val Pro Val 
        355                 360                 365             


Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu Thr Gln Gly Asp Gly 
    370                 375                 380                 


Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser Gln Lys Pro Leu Ser 
385                 390                 395                 400 


Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser Glu Ala Glu Gln Ala 
                405                 410                 415     


Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr Val Gly Asn Ser Asn 
            420                 425                 430         


Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu Leu Arg Pro Gly Glu 
        435                 440                 445             


Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp Arg Ala His Glu Ala 
    450                 455                 460                 


Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn Lys Gly Arg Leu Leu 
465                 470                 475                 480 


Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln Asp Leu Val Val Leu 
                485                 490                 495     


Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser Phe Arg Leu Val Ala 
            500                 505                 510         


Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg Glu Val Val Ala Asp 
        515                 520                 525             


Ser Val Trp Val Asp Val Lys Asp Ser Cys Val Gly Ser Leu Val Val 
    530                 535                 540                 


Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val Pro Gly Gln Gln Met 
545                 550                 555                 560 


Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg Val Val Leu Val Ala 
                565                 570                 575     


Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys Asn Lys Leu Thr Gln 
            580                 585                 590         


Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp Ile Gly Cys Thr Pro 
        595                 600                 605             


Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser Asp Ala Gly Leu Thr 
    610                 615                 620                 


Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln Arg Ala Glu Leu Gln 
625                 630                 635                 640 


Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser Val Gln Leu Thr Glu 
                645                 650                 655     


Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys Glu Leu Arg Lys Cys 
            660                 665                 670         


Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg Phe Ser Cys Gln Arg 
        675                 680                 685             


Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys Lys Lys Val Phe Leu 
    690                 695                 700                 


Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg Gln His Ala Arg Ala 
705                 710                 715                 720 


Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp Glu Asp Ile Ile Ala 
                725                 730                 735     


Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro Glu Ser Trp Leu Trp 
            740                 745                 750         


Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn Gly Ile Ser Thr Lys 
        755                 760                 765             


Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr Thr Trp Glu Ile Leu 
    770                 775                 780                 


Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys Val Ala Asp Pro Phe 
785                 790                 795                 800 


Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp Leu Arg Leu Pro Tyr 
                805                 810                 815     


Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg Ala Val Leu Tyr Asn 
            820                 825                 830         


Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val Glu Leu Leu His Asn 
        835                 840                 845             


Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg Arg His Gln Gln Thr 
    850                 855                 860                 


Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val Pro Tyr Val Ile Val 
865                 870                 875                 880 


Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val Lys Ala Ala Val Tyr 
                885                 890                 895     


His His Phe Ile Ser Asp Gly Val Arg Lys Ser Leu Lys Val Val Pro 
            900                 905                 910         


Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val Arg Thr Leu Asp Pro 
        915                 920                 925             


Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu Asp Ile Pro Pro Ala 
    930                 935                 940                 


Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser Glu Thr Arg Ile Leu 
945                 950                 955                 960 


Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu Asp Ala Val Asp Ala 
                965                 970                 975     


Glu Arg Leu Lys His Leu Ile Val Thr Pro Ser Gly Cys Gly Glu Gln 
            980                 985                 990         


Asn Met Ile Gly Met Thr Pro Thr  Val Ile Ala Val His  Tyr Leu Asp 
        995                 1000                 1005             


Glu Thr  Glu Gln Trp Glu Lys  Phe Gly Leu Glu Lys  Arg Gln Gly 
    1010                 1015                 1020             


Ala Leu  Glu Leu Ile Lys Lys  Gly Tyr Thr Gln Gln  Leu Ala Phe 
    1025                 1030                 1035             


Arg Gln  Pro Ser Ser Ala Phe  Ala Ala Phe Val Lys  Arg Ala Pro 
    1040                 1045                 1050             


Ser Thr  Trp Leu Thr Ala Tyr  Val Val Lys Val Phe  Ser Leu Ala 
    1055                 1060                 1065             


Val Asn  Leu Ile Ala Ile Asp  Ser Gln Val Leu Cys  Gly Ala Val 
    1070                 1075                 1080             


Lys Trp  Leu Ile Leu Glu Lys  Gln Lys Pro Asp Gly  Val Phe Gln 
    1085                 1090                 1095             


Glu Asp  Ala Pro Val Ile His  Gln Glu Met Ile Gly  Gly Leu Arg 
    1100                 1105                 1110             


Asn Asn  Asn Glu Lys Asp Met  Ala Leu Thr Ala Phe  Val Leu Ile 
    1115                 1120                 1125             


Ser Leu  Gln Glu Ala Lys Asp  Ile Cys Glu Glu Gln  Val Asn Ser 
    1130                 1135                 1140             


Leu Pro  Gly Ser Ile Thr Lys  Ala Gly Asp Phe Leu  Glu Ala Asn 
    1145                 1150                 1155             


Tyr Met  Asn Leu Gln Arg Ser  Tyr Thr Val Ala Ile  Ala Gly Tyr 
    1160                 1165                 1170             


Ala Leu  Ala Gln Met Gly Arg  Leu Lys Gly Pro Leu  Leu Asn Lys 
    1175                 1180                 1185             


Phe Leu  Thr Thr Ala Lys Asp  Lys Asn Arg Trp Glu  Asp Pro Gly 
    1190                 1195                 1200             


Lys Gln  Leu Tyr Asn Val Glu  Ala Thr Ser Tyr Ala  Leu Leu Ala 
    1205                 1210                 1215             


Leu Leu  Gln Leu Lys Asp Phe  Asp Phe Val Pro Pro  Val Val Arg 
    1220                 1225                 1230             


Trp Leu  Asn Glu Gln Arg Tyr  Tyr Gly Gly Gly Tyr  Gly Ser Thr 
    1235                 1240                 1245             


Gln Ala  Thr Phe Met Val Phe  Gln Ala Leu Ala Gln  Tyr Gln Lys 
    1250                 1255                 1260             


Asp Ala  Pro Asp His Gln Glu  Leu Asn Leu Asp Val  Ser Leu Gln 
    1265                 1270                 1275             


Leu Pro  Ser Arg Ser Ser Lys  Ile Thr His Arg Ile  His Trp Glu 
    1280                 1285                 1290             


Ser Ala  Ser Leu Leu Arg Ser  Glu Glu Thr Lys Glu  Asn Glu Gly 
    1295                 1300                 1305             


Phe Thr  Val Thr Ala Glu Gly  Lys Gly Gln Gly Thr  Leu Ser Val 
    1310                 1315                 1320             


Val Thr  Met Tyr His Ala Lys  Ala Lys Asp Gln Leu  Thr Cys Asn 
    1325                 1330                 1335             


Lys Phe  Asp Leu Lys Val Thr  Ile Lys Pro Ala Pro  Glu Thr Glu 
    1340                 1345                 1350             


Lys Arg  Pro Gln Asp Ala Lys  Asn Thr Met Ile Leu  Glu Ile Cys 
    1355                 1360                 1365             


Thr Arg  Tyr Arg Gly Asp Gln  Asp Ala Thr Met Ser  Ile Leu Asp 
    1370                 1375                 1380             


Ile Ser  Met Met Thr Gly Phe  Ala Pro Asp Thr Asp  Asp Leu Lys 
    1385                 1390                 1395             


Gln Leu  Ala Asn Gly Val Asp  Arg Tyr Ile Ser Lys  Tyr Glu Leu 
    1400                 1405                 1410             


Asp Lys  Ala Phe Ser Asp Arg  Asn Thr Leu Ile Ile  Tyr Leu Asp 
    1415                 1420                 1425             


Lys Val  Ser His Ser Glu Asp  Asp Cys Leu Ala Phe  Lys Val His 
    1430                 1435                 1440             


Gln Tyr  Phe Asn Val Glu Leu  Ile Gln Pro Gly Ala  Val Lys Val 
    1445                 1450                 1455             


Tyr Ala  Tyr Tyr Asn Leu Glu  Glu Ser Cys Thr Arg  Phe Tyr His 
    1460                 1465                 1470             


Pro Glu  Lys Glu Asp Gly Lys  Leu Asn Lys Leu Cys  Arg Asp Glu 
    1475                 1480                 1485             


Leu Cys  Arg Cys Ala Glu Glu  Asn Cys Phe Ile Gln  Lys Ser Asp 
    1490                 1495                 1500             


Asp Lys  Val Thr Leu Glu Glu  Arg Leu Asp Lys Ala  Cys Glu Pro 
    1505                 1510                 1515             


Gly Val  Asp Tyr Val Tyr Lys  Thr Arg Leu Val Lys  Val Gln Leu 
    1520                 1525                 1530             


Ser Asn  Asp Phe Asp Glu Tyr  Ile Met Ala Ile Glu  Gln Thr Ile 
    1535                 1540                 1545             


Lys Ser  Gly Ser Asp Glu Val  Gln Val Gly Gln Gln  Arg Thr Phe 
    1550                 1555                 1560             


Ile Ser  Pro Ile Lys Cys Arg  Glu Ala Leu Lys Leu  Glu Glu Lys 
    1565                 1570                 1575             


Lys His  Tyr Leu Met Trp Gly  Leu Ser Ser Asp Phe  Trp Gly Glu 
    1580                 1585                 1590             


Lys Pro  Asn Leu Ser Tyr Ile  Ile Gly Lys Asp Thr  Trp Val Glu 
    1595                 1600                 1605             


His Trp  Pro Glu Glu Asp Glu  Cys Gln Asp Glu Glu  Asn Gln Lys 
    1610                 1615                 1620             


Gln Cys  Gln Asp Leu Gly Ala  Phe Thr Glu Ser Met  Val Val Phe 
    1625                 1630                 1635             


Gly Cys  Pro Asn 
    1640         


<210>  2
<211>  4926
<212>  DNA
<213>  Homo sapiens

<400>  2
agtcccatgt actctatcat cacccccaac atcttgcggc tggagagcga ggagaccatg       60

gtgctggagg cccacgacgc gcaaggggat gttccagtca ctgttactgt ccacgacttc      120

ccaggcaaaa aactagtgct gtccagtgag aagactgtgc tgacccctgc caccaaccac      180

atgggcaacg tcaccttcac gatcccagcc aacagggagt tcaagtcaga aaaggggcgc      240

aacaagttcg tgaccgtgca ggccaccttc gggacccaag tggtggagaa ggtggtgctg      300

gtcagcctgc agagcgggta cctcttcatc cagacagaca agaccatcta cacccctggc      360

tccacagttc tctatcggat cttcaccgtc aaccacaagc tgctacccgt gggccggacg      420

gtcatggtca acattgagaa cccggaaggc atcccggtca agcaggactc cttgtcttct      480

cagaaccagc ttggcgtctt gcccttgtct tgggacattc cggaactcgt caacatgggc      540

cagtggaaga tccgagccta ctatgaaaac tcaccacagc aggtcttctc cactgagttt      600

gaggtgaagg agtacgtgct gcccagtttc gaggtcatag tggagcctac agagaaattc      660

tactacatct ataacgagaa gggcctggag gtcaccatca ccgccaggtt cctctacggg      720

aagaaagtgg agggaactgc ctttgtcatc ttcgggatcc aggatggcga acagaggatt      780

tccctgcctg aatccctcaa gcgcattccg attgaggatg gctcggggga ggttgtgctg      840

agccggaagg tactgctgga cggggtgcag aacctccgag cagaagacct ggtggggaag      900

tctttgtacg tgtctgccac cgtcatcttg cactcaggca gtgacatggt gcaggcagag      960

cgcagcggga tccccatcgt gacctctccc taccagatcc acttcaccaa gacacccaag     1020

tacttcaaac caggaatgcc ctttgacctc atggtgttcg tgacgaaccc tgatggctct     1080

ccagcctacc gagtccccgt ggcagtccag ggcgaggaca ctgtgcagtc tctaacccag     1140

ggagatggcg tggccaaact cagcatcaac acacacccca gccagaagcc cttgagcatc     1200

acggtgcgca cgaagaagca ggagctctcg gaggcagagc aggctaccag gaccatgcag     1260

gctctgccct acagcaccgt gggcaactcc aacaattacc tgcatctctc agtgctacgt     1320

acagagctca gacccgggga gaccctcaac gtcaacttcc tcctgcgaat ggaccgcgcc     1380

cacgaggcca agatccgcta ctacacctac ctgatcatga acaagggcag gctgttgaag     1440

gcgggacgcc aggtgcgaga gcccggccag gacctggtgg tgctgcccct gtccatcacc     1500

accgacttca tcccttcctt ccgcctggtg gcgtactaca cgctgatcgg tgccagcggc     1560

cagagggagg tggtggccga ctccgtgtgg gtggacgtca aggactcctg cgtgggctcg     1620

ctggtggtaa aaagcggcca gtcagaagac cggcagcctg tacctgggca gcagatgacc     1680

ctgaagatag agggtgacca cggggcccgg gtggtactgg tggccgtgga caagggcgtg     1740

ttcgtgctga ataagaagaa caaactgacg cagagtaaga tctgggacgt ggtggagaag     1800

gcagacatcg gctgcacccc gggcagtggg aaggattacg ccggtgtctt ctccgacgca     1860

gggctgacct tcacgagcag cagtggccag cagaccgccc agagggcaga acttcagtgc     1920

ccgcagccag ccgcccgccg acgccgttcc gtgcagctca cggagaagcg aatggacaaa     1980

gtcggcaagt accccaagga gctgcgcaag tgctgcgagg acggcatgcg ggagaacccc     2040

atgaggttct cgtgccagcg ccggacccgt ttcatctccc tgggcgaggc gtgcaagaag     2100

gtcttcctgg actgctgcaa ctacatcaca gagctgcggc ggcagcacgc gcgggccagc     2160

cacctgggcc tggccaggag taacctggat gaggacatca ttgcagaaga gaacatcgtt     2220

tcccgaagtg agttcccaga gagctggctg tggaacgttg aggacttgaa agagccaccg     2280

aaaaatggaa tctctacgaa gctcatgaat atatttttga aagactccat caccacgtgg     2340

gagattctgg ctgtcagcat gtcggacaag aaagggatct gtgtggcaga ccccttcgag     2400

gtcacagtaa tgcaggactt cttcatcgac ctgcggctac cctactctgt tgttcgaaac     2460

gagcaggtgg aaatccgagc cgttctctac aattaccggc agaaccaaga gctcaaggtg     2520

agggtggaac tactccacaa tccagccttc tgcagcctgg ccaccaccaa gaggcgtcac     2580

cagcagaccg taaccatccc ccccaagtcc tcgttgtccg ttccatatgt catcgtgccg     2640

ctaaagaccg gcctgcagga agtggaagtc aaggctgccg tctaccatca tttcatcagt     2700

gacggtgtca ggaagtccct gaaggtcgtg ccggaaggaa tcagaatgaa caaaactgtg     2760

gctgttcgca ccctggatcc agaacgcctg ggccgtgaag gagtgcagaa agaggacatc     2820

ccacctgcag acctcagtga ccaagtcccg gacaccgagt ctgagaccag aattctcctg     2880

caagggaccc cagtggccca gatgacagag gatgccgtcg acgcggaacg gctgaagcac     2940

ctcattgtga ccccctcggg ctgcggggaa cagaacatga tcggcatgac gcccacggtc     3000

atcgctgtgc attacctgga tgaaacggag cagtgggaga agttcggcct agagaagcgg     3060

cagggggcct tggagctcat caagaagggg tacacccagc agctggcctt cagacaaccc     3120

agctctgcct ttgcggcctt cgtgaaacgg gcacccagca cctggctgac cgcctacgtg     3180

gtcaaggtct tctctctggc tgtcaacctc atcgccatcg actcccaagt cctctgcggg     3240

gctgttaaat ggctgatcct ggagaagcag aagcccgacg gggtcttcca ggaggatgcg     3300

cccgtgatac accaagaaat gattggtgga ttacggaaca acaacgagaa agacatggcc     3360

ctcacggcct ttgttctcat ctcgctgcag gaggctaaag atatttgcga ggagcaggtc     3420

aacagcctgc caggcagcat cactaaagca ggagacttcc ttgaagccaa ctacatgaac     3480

ctacagagat cctacactgt ggccattgct ggctatgctc tggcccagat gggcaggctg     3540

aaggggcctc ttcttaacaa atttctgacc acagccaaag ataagaaccg ctgggaggac     3600

cctggtaagc agctctacaa cgtggaggcc acatcctatg ccctcttggc cctactgcag     3660

ctaaaagact ttgactttgt gcctcccgtc gtgcgttggc tcaatgaaca gagatactac     3720

ggtggtggct atggctctac ccaggccacc ttcatggtgt tccaagcctt ggctcaatac     3780

caaaaggacg cccctgacca ccaggaactg aaccttgatg tgtccctcca actgcccagc     3840

cgcagctcca agatcaccca ccgtatccac tgggaatctg ccagcctcct gcgatcagaa     3900

gagaccaagg aaaatgaggg tttcacagtc acagctgaag gaaaaggcca aggcaccttg     3960

tcggtggtga caatgtacca tgctaaggcc aaagatcaac tcacctgtaa taaattcgac     4020

ctcaaggtca ccataaaacc agcaccggaa acagaaaaga ggcctcagga tgccaagaac     4080

actatgatcc ttgagatctg taccaggtac cggggagacc aggatgccac tatgtctata     4140

ttggacatat ccatgatgac tggctttgct ccagacacag atgacctgaa gcagctggcc     4200

aatggtgttg acagatacat ctccaagtat gagctggaca aagccttctc cgataggaac     4260

accctcatca tctacctgga caaggtctca cactctgagg atgactgtct agctttcaaa     4320

gttcaccaat actttaatgt agagcttatc cagcctggag cagtcaaggt ctacgcctat     4380

tacaacctgg aggaaagctg tacccggttc taccatccgg aaaaggagga tggaaagctg     4440

aacaagctct gccgtgatga actgtgccgc tgtgctgagg agaattgctt catacaaaag     4500

tcggatgaca aggtcaccct ggaagaacgg ctggacaagg cctgtgagcc aggagtggac     4560

tatgtgtaca agacccgact ggtcaaggtt cagctgtcca atgactttga cgagtacatc     4620

atggccattg agcagaccat caagtcaggc tcggatgagg tgcaggttgg acagcagcgc     4680

acgttcatca gccccatcaa gtgcagagaa gccctgaagc tggaggagaa gaaacactac     4740

ctcatgtggg gtctctcctc cgatttctgg ggagagaagc ccaacctcag ctacatcatc     4800

gggaaggaca cttgggtgga gcactggcct gaggaggacg aatgccaaga cgaagagaac     4860

cagaaacaat gccaggacct cggcgccttc accgagagca tggttgtctt tgggtgcccc     4920

aactga                                                                4926


