                         SEQUENCE LISTING

<110>  Universite du Luxembourg
 
<120>  Means and methods for generating midbrain organoids

<130>  LUX15542PCT

<150>  92845
<151>  2015-10-08

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  5844
<212>  DNA
<213>  Homo sapiens

<400>  1
agtctggggc gggcgctcgg gctgcgcggg ctctgggcag cagcagcagc agcagcagca       60

tcctctcttc ctttacttcc cttccgcttc tttctcttcc ttctccttct ttttcccccc      120

cctccccttc ttcccctaac ccttctaccc ctctcctttt tctccggagg gcgctaagtc      180

cgtgagcggt ggcagtcgcg accgcgggtg catccagttt ctgcgcccag attttattga      240

tctaatccaa agtatcttat aacttctggc tggaattaag attcttcagc ttgtctctaa      300

ccgaggaagc attgattggg agctactcat tcagaaaatt aaaagaaaga agccagaaaa      360

tattatcaac cctttgagaa cacgacacaa cgaactttat attttaccac ttccttgaat      420

agttgcagga gaaataacaa ggcattgaag aatggcagat gaacggaaag atgaagcaaa      480

ggcacctcac tggacctcag caccgctaac agaggcatct gcacactcac atccacctga      540

gattaaggat caaggcggag caggggaagg acttgtccga agcgccaatg gattcccata      600

cagggaggat gaagagggtg cctttggaga gcatgggtca cagggcacct attcaaatac      660

caaagagaat gggatcaacg gagagctgac ctcagctgac agagaaacag cagaggaggt      720

gtctgcaagg atagttcaag tagtcactgc tgaggctgta gcagtcctga aaggtgaaca      780

agagaaagaa gctcaacata aagaccagac tgcagctctg cctttagcag ctgaagaaac      840

agctaatctg cctccttctc cacccccatc acctgcctca gaacagactg tcacagtgga      900

ggaagcagca ggtggggaat cagctctggc tcccagtgta tttaaacagg caaaggacaa      960

agtctctaat tctaccttgt caaagattcc tgctttacag ggtagcacaa agtccccaag     1020

atacagctca gcctgcccta gcacgactaa aagggctaca ttttctgaca gtttattaat     1080

acagcccacc tcagcaggct ccacagaccg tttgccatac tcaaaatcag ggaacaagga     1140

cggagtaacc aagagcccag aaaagcgctc ttctctccca agaccttcct ccattctccc     1200

tcctcggcga ggtgtgtcag gagacagaga tgagaattcc ttctctctca acagttctat     1260

ctcttcttca gcacggcgga ccaccaggtc agagccaatt cgcagagcag ggaagagtgg     1320

tacctcaaca cccactaccc ctgggtctac tgccatcact cctggcaccc caccaagtta     1380

ttcttcacgc acaccaggca ctcctggaac ccctagctat cccaggaccc ctcacacacc     1440

aggaaccccc aagtctgcca tcttggtgcc gagtgagaag aaggtcgcca tcatacgtac     1500

tcctccaaaa tctcctgcga ctcccaagca gcttcggctt attaaccaac cactgccaga     1560

cctgaagaat gtcaaatcca aaatcggatc aacagacaac atcaaatacc agcctaaagg     1620

ggggcaggtt aggattttaa acaagaagat cgattttagc aaagttcagt ccagatgtgg     1680

ttccaaggat aacatcaaac attcggctgg gggcggaaat gtacaaattg ttaccaagaa     1740

aatagaccta agccatgtga catccaaatg tggctctctg aagaacatcc gccacaggcc     1800

aggtggcgga cgtgtgaaaa ttgagagtgt aaaactagat ttcaaagaaa aggcccaagc     1860

taaagttggt tctcttgata atgctcatca tgtacctgga ggtggtaatg tcaagattga     1920

cagccaaaag ttgaacttca gagagcatgc taaagcccgt gtggaccatg gggctgagat     1980

cattacacag tccccaggca gatccagcgt ggcatcaccc cgacgactca gcaatgtctc     2040

ctcgtctgga agcatcaacc tgctcgaatc tcctcagctt gccactttgg ctgaggatgt     2100

cactgctgca ctcgctaagc agggcttgtg aatatttctc atttagcatt gaaataataa     2160

tatttaggca tgagctcttg gcaggagtgg gctctgagca gttgttatat tcattcttta     2220

taaaccataa aataaataat ctcatcccca aactgtagta attgttacaa ttttctattt     2280

aaaaaatgaa tagtacatgc agaaattgac ctgatttcca tttgcaacag gaagacactg     2340

gctttacatg ggttcaattg gacaattatt tttgctctgc tctgttttgc atggagtatt     2400

attattttaa aaattgcatt tttacctttc atgtgcctga aggctatcca ctacattctg     2460

aaggccttgt taaaatccaa gctgctcatt tcactattct gtttctgagt gagaagataa     2520

aaactgccca ttgtaactta tttcaggtta aattaaacca aggagtctga ttgcaggaag     2580

ggaagagcat gtaagaaata agttttttta aagtgttatt ttgtataaat gggaagaaag     2640

attcaattaa gttattaaca tttgggacct ggataattat atcagagtat gtcagtccaa     2700

taaattattt aactaattaa aaaatagttg caaagcattt gagctgtggt tgaggaagtg     2760

gtgtaaaagt gcatccatta ggaatgatgc actttcatta ggatggactc gtgtctgatt     2820

agaatgtcag ttgatcagct agatttgtgt ccacactacc agtttcacac cccctttcca     2880

tctgtttgat acagtattat agatataaat atatatatat ttctctgtgg ccatttgtga     2940

tacttcctca tatacttgaa tattatactt ctttattcac agtatctgtg tctcctgcac     3000

cctttggtgt tgcaatttta gatatgtgaa agtagatgtt agcagggttc tctccctatt     3060

taaaaaaaat acattaaaaa agacaaaaaa ttttagcatg aagttgcttt ctgtaacaac     3120

tcaaagccgt aaccctgttt tagtgccaga tacaagtctc tcccgtgatg ctagacaaaa     3180

aattattttt ctttgctttc accaacatgg agtttgtggg ggtgggtcca gttatacatg     3240

aaagggttta cagattgttg gtttaagatt atggatttat ctcattttta atcacaggat     3300

agtttggggt ttattcctat tattattcat gaaaccgact taagattttt tctttatttt     3360

tctttttttt tccatttgct aaagttgaaa gttgaaacta actataatag tttgaaacat     3420

gttttctcat ttttccaaat agtatctgtt tattaaattc tctaatagaa gatgtttgtc     3480

tttcttaccc aaagtaaaga tcccctgatc agaaagaaaa aatacaatac tttgggaagc     3540

tatagctata aaacacttga gacacagata tctaaatcag tttttttcca agactccaac     3600

attgcactct gtaaagtaac acactgtgat ctagtattat ttatcagtag ataatactgt     3660

tctgactgta tatacagtct agaactcaca aatcaattag ttcctctcac aaatcattca     3720

tcttagactt acaaataagg aatgaaatag tcaatggcct gattaaggca aagagctacc     3780

aggctagatg gacacttttt aaaaatttta tctgttcttt ttcttgctca gggctggtag     3840

gttggatctg aaccattaaa atcaaatggt ccactaggcg tatgatctct ttgagccaaa     3900

tcagttcctg aatataaagg aggaaatgat gaggatgtac tgaggcaacg gggaagtata     3960

gaaacatcca agacaaaagc caagggatgc aaaggcagag acacaggtgc tttttggtga     4020

cccagtggat atggcaacca gtgtaactgc catacaagaa accctaggag caaacccaca     4080

ccactcattc tcagctaaga gattttacac aggcaaacgt gtcttaaacc atctataaat     4140

cagttatttt atatgacagt caaaacctta gaaaccttag gatcattata tctattttct     4200

gcctattaat tgctgtgagg tttgatttga ccaatctggg caatttattc atcagcttcc     4260

cttgaagtgc accagaaaat agaagaaagg tgtgtggaga cttagggtat tttattacat     4320

gttttcatag tcttaaatag tgattaaatt tctctagaaa gaagttaaca gctcattaga     4380

aaagttttaa cctgtgaaat aagtattttt ctcaacattc tttaaagttt ttatataagt     4440

taacactagg taaacattct gcatactaga agtcagttta ttacaaatac atgtcaaaaa     4500

taaagattat acaaggcacc aaactactag atttggcatt aaaacaaatg tttatttcta     4560

atcacaacaa aattataatg aataaatgtt cttgctttgt atggaaatac aattctttat     4620

taaagttaac agaaaggaac tgatcgtttg taccagtaaa agagagaaac acacaggtta     4680

aatatcttct tgtggggtta aggggtagaa cctatcttgc cttcactctc aagataacga     4740

ctcaaattaa gctttttgag caccactctt gtggggacac acatacgctg atctaggaat     4800

gaaatcttcg tggtctcaat tctagatcta ctatgccagt ttctctctgg ctttagcctt     4860

tgagaacctg tataagaata cgtaagtaat ccagagctgt gaagagttta aaggccaact     4920

tctccagtga actcaacctc tgggtcactt gcaaccagaa attggatacc tcataatgat     4980

gcaggaaaga cccgagttca tgatgagttt caaaggccac gttcatttag gaaccaactc     5040

tctctggatt tacctgctga gttccagcag cgtgatgggc tgacatccca cctacaagta     5100

tgacacctgt gtaacaccag ctaggtacgg ctggagaagg ctgaagagag aatgccatta     5160

aatggaagaa tgtactgatt gtagtgacct tctccacaca cacacacaca cacacacaca     5220

cacacaccta cagtaataca gcaagcgtgg aataatcagc caatatataa cattccatca     5280

gtattttatt aaggaaataa cctgaatgtg gttgattttg acatagctgc aattacagtt     5340

ttcttctatt tttcaagcca caataaggaa aataaactac tcatggtcta aatactagag     5400

ataaagtaga ttcatggctt ggtaaggaaa ttttaagcat tccttcaaag attgacgtgc     5460

taaaataagc attgatgttt tgagtttttt tacacctagg atttttagct tgggtgtgta     5520

ggtgaaggcc aagactctct gcaggaaaaa gcttattttc aaactcagaa aataaaatgt     5580

caatcataaa aatctacttc aactttagca aaaagaaaaa aaaatcaaca aaaagtatac     5640

tctgtatgct gggattccga ggttccaaca cactgttaca aatctgtggg gggtttcttt     5700

cttctgataa ttctagagcc tgttaccata gaaaggcatt tcttcaatgg ctggttgtag     5760

ttagttcatg tttttcaatc aaatttgcaa atgtatttgt tgctgtatag tgattgtttt     5820

gcaaaataaa attgcttgtc acct                                            5844


<210>  2
<211>  1827
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser 
1               5                   10                  15      


Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys 
            20                  25                  30          


Asp Gln Gly Gly Ala Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe 
        35                  40                  45              


Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln 
    50                  55                  60                  


Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr 
65                  70                  75                  80  


Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln 
                85                  90                  95      


Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Gly Glu Gln Glu Lys 
            100                 105                 110         


Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu 
        115                 120                 125             


Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu 
    130                 135                 140                 


Gln Thr Val Thr Val Glu Glu Asp Leu Leu Thr Ala Ser Lys Met Glu 
145                 150                 155                 160 


Phe His Asp Gln Gln Glu Leu Thr Pro Ser Thr Ala Glu Pro Ser Asp 
                165                 170                 175     


Gln Lys Glu Lys Glu Ser Glu Lys Gln Ser Lys Pro Gly Glu Asp Leu 
            180                 185                 190         


Lys His Ala Ala Leu Val Ser Gln Pro Glu Thr Thr Lys Thr Tyr Pro 
        195                 200                 205             


Asp Lys Lys Asp Met Gln Gly Thr Glu Glu Glu Lys Ala Pro Leu Ala 
    210                 215                 220                 


Leu Phe Gly His Thr Leu Val Ala Ser Leu Glu Asp Met Lys Gln Lys 
225                 230                 235                 240 


Thr Glu Pro Ser Leu Val Val Pro Gly Ile Asp Leu Pro Lys Glu Pro 
                245                 250                 255     


Pro Thr Pro Lys Glu Gln Lys Asp Trp Phe Ile Glu Met Pro Thr Glu 
            260                 265                 270         


Ala Lys Lys Asp Glu Trp Gly Leu Val Ala Pro Ile Ser Pro Gly Pro 
        275                 280                 285             


Leu Thr Pro Met Arg Glu Lys Asp Val Phe Asp Asp Ile Pro Lys Trp 
    290                 295                 300                 


Glu Gly Lys Gln Phe Asp Ser Pro Met Pro Ser Pro Phe Gln Gly Gly 
305                 310                 315                 320 


Ser Phe Thr Leu Pro Leu Asp Val Met Lys Asn Glu Ile Val Thr Glu 
                325                 330                 335     


Thr Ser Pro Phe Ala Pro Ala Phe Leu Gln Pro Asp Asp Lys Lys Ser 
            340                 345                 350         


Leu Gln Gln Thr Ser Gly Pro Ala Thr Ala Lys Asp Ser Phe Lys Ile 
        355                 360                 365             


Glu Glu Pro His Glu Ala Lys Pro Asp Lys Met Ala Glu Ala Pro Pro 
    370                 375                 380                 


Ser Glu Ala Met Thr Leu Pro Lys Asp Ala His Ile Pro Val Val Glu 
385                 390                 395                 400 


Glu His Val Met Gly Lys Val Leu Glu Glu Glu Lys Glu Ala Ile Asn 
                405                 410                 415     


Gln Glu Thr Val Gln Gln Arg Asp Thr Phe Thr Pro Ser Gly Gln Glu 
            420                 425                 430         


Pro Ile Leu Thr Glu Lys Glu Thr Glu Leu Lys Leu Glu Glu Lys Thr 
        435                 440                 445             


Thr Ile Ser Asp Lys Glu Ala Val Pro Lys Glu Ser Lys Pro Pro Lys 
    450                 455                 460                 


Pro Ala Asp Glu Glu Ile Gly Ile Ile Gln Thr Ser Thr Glu His Thr 
465                 470                 475                 480 


Phe Ser Glu Gln Lys Asp Gln Glu Pro Thr Thr Asp Met Leu Lys Gln 
                485                 490                 495     


Asp Ser Phe Pro Val Ser Leu Glu Gln Ala Val Thr Asp Ser Ala Met 
            500                 505                 510         


Thr Ser Lys Thr Leu Glu Lys Ala Met Thr Glu Pro Ser Ala Leu Ile 
        515                 520                 525             


Glu Lys Ser Ser Ile Gln Glu Leu Phe Glu Met Arg Val Asp Asp Lys 
    530                 535                 540                 


Asp Lys Ile Glu Gly Val Gly Ala Ala Thr Ser Ala Glu Leu Asp Met 
545                 550                 555                 560 


Pro Phe Tyr Glu Asp Lys Ser Gly Met Ser Lys Tyr Phe Glu Thr Ser 
                565                 570                 575     


Ala Leu Lys Glu Glu Ala Thr Lys Ser Ile Glu Pro Gly Ser Asp Tyr 
            580                 585                 590         


Tyr Glu Leu Ser Asp Thr Arg Glu Ser Val His Glu Ser Ile Asp Thr 
        595                 600                 605             


Met Ser Pro Met His Lys Asn Gly Asp Lys Glu Phe Gln Thr Gly Lys 
    610                 615                 620                 


Glu Ser Gln Pro Ser Pro Pro Ala Gln Glu Ala Gly Tyr Ser Thr Leu 
625                 630                 635                 640 


Ala Gln Ser Tyr Pro Ser Asp Leu Pro Glu Glu Pro Ser Ser Pro Gln 
                645                 650                 655     


Glu Arg Met Phe Thr Ile Asp Pro Lys Val Tyr Gly Glu Lys Arg Asp 
            660                 665                 670         


Leu His Ser Lys Asn Lys Asp Asp Leu Thr Leu Ser Arg Ser Leu Gly 
        675                 680                 685             


Leu Gly Gly Arg Ser Ala Ile Glu Gln Arg Ser Met Ser Ile Asn Leu 
    690                 695                 700                 


Pro Met Ser Cys Leu Asp Ser Ile Ala Leu Gly Phe Asn Phe Gly Arg 
705                 710                 715                 720 


Gly His Asp Leu Ser Pro Leu Ala Ser Asp Ile Leu Thr Asn Thr Ser 
                725                 730                 735     


Gly Ser Met Asp Glu Gly Asp Asp Tyr Leu Pro Ala Thr Thr Pro Ala 
            740                 745                 750         


Leu Glu Lys Ala Pro Cys Phe Pro Val Glu Ser Lys Glu Glu Glu Gln 
        755                 760                 765             


Ile Glu Lys Val Lys Ala Thr Gly Glu Glu Ser Thr Gln Ala Glu Ile 
    770                 775                 780                 


Ser Cys Glu Ser Pro Phe Leu Ala Lys Asp Phe Tyr Lys Asn Gly Thr 
785                 790                 795                 800 


Val Met Ala Pro Asp Leu Pro Glu Met Leu Asp Leu Ala Gly Thr Arg 
                805                 810                 815     


Ser Arg Leu Ala Ser Val Ser Ala Asp Ala Glu Val Ala Arg Arg Lys 
            820                 825                 830         


Ser Val Pro Ser Glu Thr Val Val Glu Asp Ser Arg Thr Gly Leu Pro 
        835                 840                 845             


Pro Val Thr Asp Glu Asn His Val Ile Val Lys Thr Asp Ser Gln Leu 
    850                 855                 860                 


Glu Asp Leu Gly Tyr Cys Val Phe Asn Lys Tyr Thr Val Pro Leu Pro 
865                 870                 875                 880 


Ser Pro Val Gln Asp Ser Glu Asn Leu Ser Gly Glu Ser Gly Thr Phe 
                885                 890                 895     


Tyr Glu Gly Thr Asp Asp Lys Val Arg Arg Asp Leu Ala Thr Asp Leu 
            900                 905                 910         


Ser Leu Ile Glu Val Lys Leu Ala Ala Ala Gly Arg Val Lys Asp Glu 
        915                 920                 925             


Phe Ser Val Asp Lys Glu Ala Ser Ala His Ile Ser Gly Asp Lys Ser 
    930                 935                 940                 


Gly Leu Ser Lys Glu Phe Asp Gln Glu Lys Lys Ala Asn Asp Arg Leu 
945                 950                 955                 960 


Asp Thr Val Leu Glu Lys Ser Glu Glu His Ala Asp Ser Lys Glu His 
                965                 970                 975     


Ala Lys Lys Thr Glu Glu Ala Gly Asp Glu Ile Glu Thr Phe Gly Leu 
            980                 985                 990         


Gly Val Thr Tyr Glu Gln Ala Leu  Ala Lys Asp Leu Ser  Ile Pro Thr 
        995                 1000                 1005             


Asp Ala  Ser Ser Glu Lys Ala  Glu Lys Gly Leu Ser  Ser Val Pro 
    1010                 1015                 1020             


Glu Ile  Ala Glu Val Glu Pro  Ser Lys Lys Val Glu  Gln Gly Leu 
    1025                 1030                 1035             


Asp Phe  Ala Val Gln Gly Gln  Leu Asp Val Lys Ile  Ser Asp Phe 
    1040                 1045                 1050             


Gly Gln  Met Ala Ser Gly Leu  Asn Ile Asp Asp Arg  Arg Ala Thr 
    1055                 1060                 1065             


Glu Leu  Lys Leu Glu Ala Thr  Gln Asp Met Thr Pro  Ser Ser Lys 
    1070                 1075                 1080             


Ala Pro  Gln Glu Ala Asp Ala  Phe Met Gly Val Glu  Ser Gly His 
    1085                 1090                 1095             


Met Lys  Glu Gly Thr Lys Val  Ser Glu Thr Glu Val  Lys Glu Lys 
    1100                 1105                 1110             


Val Ala  Lys Pro Asp Leu Val  His Gln Glu Ala Val  Asp Lys Glu 
    1115                 1120                 1125             


Glu Ser  Tyr Glu Ser Ser Gly  Glu His Glu Ser Leu  Thr Met Glu 
    1130                 1135                 1140             


Ser Leu  Lys Ala Asp Glu Gly  Lys Lys Glu Thr Ser  Pro Glu Ser 
    1145                 1150                 1155             


Ser Leu  Ile Gln Asp Glu Ile  Ala Val Lys Leu Ser  Val Glu Ile 
    1160                 1165                 1170             


Pro Cys  Pro Pro Ala Val Ser  Glu Ala Asp Leu Ala  Thr Asp Glu 
    1175                 1180                 1185             


Arg Ala  Asp Val Gln Met Glu  Phe Ile Gln Gly Pro  Lys Glu Glu 
    1190                 1195                 1200             


Ser Lys  Glu Thr Pro Asp Ile  Ser Ile Thr Pro Ser  Asp Val Ala 
    1205                 1210                 1215             


Glu Pro  Leu His Glu Thr Ile  Val Ser Glu Pro Ala  Glu Ile Gln 
    1220                 1225                 1230             


Ser Glu  Glu Glu Glu Ile Glu  Ala Gln Gly Glu Tyr  Asp Lys Leu 
    1235                 1240                 1245             


Leu Phe  Arg Ser Asp Thr Leu  Gln Ile Thr Asp Leu  Gly Val Ser 
    1250                 1255                 1260             


Gly Ala  Arg Glu Glu Phe Val  Glu Thr Cys Pro Ser  Glu His Lys 
    1265                 1270                 1275             


Gly Val  Ile Glu Ser Val Val  Thr Ile Glu Asp Asp  Phe Ile Thr 
    1280                 1285                 1290             


Val Val  Gln Thr Thr Thr Asp  Glu Gly Glu Ser Gly  Ser His Ser 
    1295                 1300                 1305             


Val Arg  Phe Ala Ala Leu Glu  Gln Pro Glu Val Glu  Arg Arg Pro 
    1310                 1315                 1320             


Ser Pro  His Asp Glu Glu Glu  Phe Glu Val Glu Glu  Ala Ala Glu 
    1325                 1330                 1335             


Ala Gln  Ala Glu Pro Lys Asp  Gly Ser Pro Glu Ala  Pro Ala Ser 
    1340                 1345                 1350             


Pro Glu  Arg Glu Glu Val Ala  Leu Ser Glu Tyr Lys  Thr Glu Thr 
    1355                 1360                 1365             


Tyr Asp  Asp Tyr Lys Asp Glu  Thr Thr Ile Asp Asp  Ser Ile Met 
    1370                 1375                 1380             


Asp Ala  Asp Ser Leu Trp Val  Asp Thr Gln Asp Asp  Asp Arg Ser 
    1385                 1390                 1395             


Ile Met  Thr Glu Gln Leu Glu  Thr Ile Pro Lys Glu  Glu Lys Ala 
    1400                 1405                 1410             


Glu Lys  Glu Ala Arg Arg Ser  Ser Leu Glu Lys His  Arg Lys Glu 
    1415                 1420                 1425             


Lys Pro  Phe Lys Thr Gly Arg  Gly Arg Ile Ser Thr  Pro Glu Arg 
    1430                 1435                 1440             


Lys Val  Ala Lys Lys Glu Pro  Ser Thr Val Ser Arg  Asp Glu Val 
    1445                 1450                 1455             


Arg Arg  Lys Lys Ala Val Tyr  Lys Lys Ala Glu Leu  Ala Lys Lys 
    1460                 1465                 1470             


Thr Glu  Val Gln Ala His Ser  Pro Ser Arg Lys Phe  Ile Leu Lys 
    1475                 1480                 1485             


Pro Ala  Ile Lys Tyr Thr Arg  Pro Thr His Leu Ser  Cys Val Lys 
    1490                 1495                 1500             


Arg Lys  Thr Thr Ala Ala Gly  Gly Glu Ser Ala Leu  Ala Pro Ser 
    1505                 1510                 1515             


Val Phe  Lys Gln Ala Lys Asp  Lys Val Ser Asp Gly  Val Thr Lys 
    1520                 1525                 1530             


Ser Pro  Glu Lys Arg Ser Ser  Leu Pro Arg Pro Ser  Ser Ile Leu 
    1535                 1540                 1545             


Pro Pro  Arg Arg Gly Val Ser  Gly Asp Arg Asp Glu  Asn Ser Phe 
    1550                 1555                 1560             


Ser Leu  Asn Ser Ser Ile Ser  Ser Ser Ala Arg Arg  Thr Thr Arg 
    1565                 1570                 1575             


Ser Glu  Pro Ile Arg Arg Ala  Gly Lys Ser Gly Thr  Ser Thr Pro 
    1580                 1585                 1590             


Thr Thr  Pro Gly Ser Thr Ala  Ile Thr Pro Gly Thr  Pro Pro Ser 
    1595                 1600                 1605             


Tyr Ser  Ser Arg Thr Pro Gly  Thr Pro Gly Thr Pro  Ser Tyr Pro 
    1610                 1615                 1620             


Arg Thr  Pro His Thr Pro Gly  Thr Pro Lys Ser Ala  Ile Leu Val 
    1625                 1630                 1635             


Pro Ser  Glu Lys Lys Val Ala  Ile Ile Arg Thr Pro  Pro Lys Ser 
    1640                 1645                 1650             


Pro Ala  Thr Pro Lys Gln Leu  Arg Leu Ile Asn Gln  Pro Leu Pro 
    1655                 1660                 1665             


Asp Leu  Lys Asn Val Lys Ser  Lys Ile Gly Ser Thr  Asp Asn Ile 
    1670                 1675                 1680             


Lys Tyr  Gln Pro Lys Gly Gly  Gln Val Gln Ile Val  Thr Lys Lys 
    1685                 1690                 1695             


Ile Asp  Leu Ser His Val Thr  Ser Lys Cys Gly Ser  Leu Lys Asn 
    1700                 1705                 1710             


Ile Arg  His Arg Pro Gly Gly  Gly Arg Val Lys Ile  Glu Ser Val 
    1715                 1720                 1725             


Lys Leu  Asp Phe Lys Glu Lys  Ala Gln Ala Lys Val  Gly Ser Leu 
    1730                 1735                 1740             


Asp Asn  Ala His His Val Pro  Gly Gly Gly Asn Val  Lys Ile Asp 
    1745                 1750                 1755             


Ser Gln  Lys Leu Asn Phe Arg  Glu His Ala Lys Ala  Arg Val Asp 
    1760                 1765                 1770             


His Gly  Ala Glu Ile Ile Thr  Gln Ser Pro Gly Arg  Ser Ser Val 
    1775                 1780                 1785             


Ala Ser  Pro Arg Arg Leu Ser  Asn Val Ser Ser Ser  Gly Ser Ile 
    1790                 1795                 1800             


Asn Leu  Leu Glu Ser Pro Gln  Leu Ala Thr Leu Ala  Glu Asp Val 
    1805                 1810                 1815             


Thr Ala  Ala Leu Ala Lys Gln  Gly Leu 
    1820                 1825         


<210>  3
<211>  1817
<212>  DNA
<213>  Homo sapiens

<400>  3
cggacctcca cactgagcca tgcccacccc cgacgccacc acgccacagg ccaagggctt       60

ccgcagggcc gtgtctgagc tggacgccaa gcaggcagag gccatcatgt ccccgcggtt      120

cattgggcgc aggcagagcc tcatcgagga cgcccgcaag gagcgggagg cggcggtggc      180

agcagcggcc gctgcagtcc cctcggagcc cggggacccc ctggaggctg tggcctttga      240

ggagaaggag gggaaggccg tgctaaacct gctcttctcc ccgagggcca ccaagccctc      300

ggcgctgtcc cgagctgtga aggtgtttga gacgtttgaa gccaaaatcc accatctaga      360

gacccggccc gcccagaggc cgcgagctgg gggcccccac ctggagtact tcgtgcgcct      420

cgaggtgcgc cgaggggacc tggccgccct gctcagtggt gtgcgccagg tgtcagagga      480

cgtgcgcagc cccgcggggc ccaaggtccc ctggttccca agaaaagtgt cagagctgga      540

caagtgtcat cacctggtca ccaagttcga ccctgacctg gacttggacc acccgggctt      600

ctcggaccag gtgtaccgcc agcgcaggaa gctgattgct gagatcgcct tccagtacag      660

gcacggcgac ccgattcccc gtgtggagta caccgccgag gagattgcca cctggaagga      720

ggtctacacc acgctgaagg gcctctacgc cacgcacgcc tgcggggagc acctggaggc      780

ctttgctttg ctggagcgct tcagcggcta ccgggaagac aatatccccc agctggagga      840

cgtctcccgc ttcctgaagg agcgcacggg cttccagctg cggcctgtgg ccggcctgct      900

gtccgcccgg gacttcctgg ccagcctggc cttccgcgtg ttccagtgca cccagtatat      960

ccgccacgcg tcctcgccca tgcactcccc tgagccggac tgctgccacg agctgctggg     1020

gcacgtgccc atgctggccg accgcacctt cgcgcagttc tcgcaggaca ttggcctggc     1080

gtccctgggg gcctcggatg aggaaattga gaagctgtcc acgctgtact ggttcacggt     1140

ggagttcggg ctgtgtaagc agaacgggga ggtgaaggcc tatggtgccg ggctgctgtc     1200

ctcctacggg gagctcctgc actgcctgtc tgaggagcct gagattcggg ccttcgaccc     1260

tgaggctgcg gccgtgcagc cctaccaaga ccagacgtac cagtcagtct acttcgtgtc     1320

tgagagcttc agtgacgcca aggacaagct caggagctat gcctcacgca tccagcgccc     1380

cttctccgtg aagttcgacc cgtacacgct ggccatcgac gtgctggaca gcccccaggc     1440

cgtgcggcgc tccctggagg gtgtccagga tgagctggac acccttgccc atgcgctgag     1500

tgccattggc taggtgcacg gcgtccctga gggcccttcc caacctcccc tggtcctgca     1560

ctgtcccgga gctcaggccc tggtgagggg ctgggtcccg ggtgcccccc atgccctccc     1620

tgctgccagg ctcccactgc ccctgcacct gcttctcagc gcaacagctg tgtgtgcccg     1680

tggtgaggtt gtgctgcctg tggtgaggtc ctgtcctggc tcccagggtc ctgggggctg     1740

ctgcactgcc ctccgccctt ccctgacact gtctgctgcc ccaatcaccg tcacaataaa     1800

agaaactgtg gtctcta                                                    1817


<210>  4
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15      


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Val Arg 
            20                  25                  30          


Gly Gln Gly Ala Pro Gly Pro Ser Leu Thr Gly Ser Pro Trp Pro Gly 
        35                  40                  45              


Thr Ala Ala Pro Ala Ala Ser Tyr Thr Pro Thr Pro Arg Ser Pro Arg 
    50                  55                  60                  


Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu Arg 
65                  70                  75                  80  


Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro Gly 
                85                  90                  95      


Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala Val 
            100                 105                 110         


Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu Ser 
        115                 120                 125             


Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His Leu 
    130                 135                 140                 


Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu Glu 
145                 150                 155                 160 


Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu Leu 
                165                 170                 175     


Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly Pro 
            180                 185                 190         


Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys His 
        195                 200                 205             


His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro Gly 
    210                 215                 220                 


Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu Ile 
225                 230                 235                 240 


Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr Thr 
                245                 250                 255     


Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys Gly 
            260                 265                 270         


Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala Leu 
        275                 280                 285             


Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu 
    290                 295                 300                 


Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg Pro 
305                 310                 315                 320 


Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala Phe 
                325                 330                 335     


Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro Met 
            340                 345                 350         


His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val Pro 
        355                 360                 365             


Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly Leu 
    370                 375                 380                 


Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr Leu 
385                 390                 395                 400 


Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu Val 
                405                 410                 415     


Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu His 
            420                 425                 430         


Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala Ala 
        435                 440                 445             


Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe Val 
    450                 455                 460                 


Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala Ser 
465                 470                 475                 480 


Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu Ala 
                485                 490                 495     


Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu Gly 
            500                 505                 510         


Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile Gly 
        515                 520                 525             


<210>  5
<211>  1794
<212>  DNA
<213>  Homo sapiens

<400>  5
gacatcagcc gatgcgaagg gcggggccgc ggctataaga gcgcgcggcc gcggtccccg       60

accctcagca gccagcccgg cccgcccgcg cccgtccgca gccgcccgcc agacgcgccc      120

agtatgaggg agatcgtgca catccaggcc ggccagtgcg gcaaccagat cggggccaag      180

ttctgggaag tcatcagtga tgagcatggc atcgacccca gcggcaacta cgtgggcgac      240

tcggacttgc agctggagcg gatcagcgtc tactacaacg aggcctcttc tcacaagtac      300

gtgcctcgag ccattctggt ggacctggaa cccggaacca tggacagtgt ccgctcaggg      360

gcctttggac atctcttcag gcctgacaat ttcatctttg gtcagagtgg ggccggcaac      420

aactgggcca agggtcacta cacggagggg gcggagctgg tggattcggt cctggatgtg      480

gtgcggaagg agtgtgaaaa ctgcgactgc ctgcagggct tccagctgac ccactcgctg      540

gggggcggca cgggctccgg catgggcacg ttgctcatca gcaaggtgcg tgaggagtat      600

cccgaccgca tcatgaacac cttcagcgtc gtgccctcac ccaaggtgtc agacacggtg      660

gtggagccct acaacgccac gctgtccatc caccagctgg tggagaacac ggatgagacc      720

tactgcatcg acaacgaggc gctctacgac atctgcttcc gcaccctcaa gctggccacg      780

cccacctacg gggacctcaa ccacctggta tcggccacca tgagcggagt caccacctcc      840

ttgcgcttcc cgggccagct caacgctgac ctgcgcaagc tggccgtcaa catggtgccc      900

ttcccgcgcc tgcacttctt catgcccggc ttcgcccccc tcacagcccg gggcagccag      960

cagtaccggg ccctgaccgt gcccgagctc acccagcaga tgttcgatgc caagaacatg     1020

atggccgcct gcgacccgcg ccacggccgc tacctgacgg tggccaccgt gttccggggc     1080

cgcatgtcca tgaaggaggt ggacgagcag atgctggcca tccagagcaa gaacagcagc     1140

tacttcgtgg agtggatccc caacaacgtg aaggtggccg tgtgtgacat cccgccccgc     1200

ggcctcaaga tgtcctccac cttcatcggg aacagcacgg ccatccagga gctgttcaag     1260

cgcatctccg agcagttcac ggccatgttc cggcgcaagg ccttcctgca ctggtacacg     1320

ggcgagggca tggacgagat ggagttcacc gaggccgaga gcaacatgaa cgacctggtg     1380

tccgagtacc agcagtacca ggacgccacg gccgaggaag agggcgagat gtacgaagac     1440

gacgaggagg agtcggaggc ccagggcccc aagtgaagct gctcgcagct ggagtgagag     1500

gcaggtggcg gccggggccg aagccagcag tgtctaaacc cccggagcca tcttgctgcc     1560

gacaccctgc tttcccctcg ccctagggct cccttgccgc cctcctgcag tatttatggc     1620

ctcgtcctcc ccacctaggc cacgtgtgag ctgctcctgt ctctgtctta ttgcagctcc     1680

aggcctgacg ttttacggtt ttgtttttta ctggtttgtg tttatatttt cggggatact     1740

taataaatct attgctgtca gataccctta aaaaaaaaaa aaaaaaaaaa aaaa           1794


<210>  6
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ser Gly Asn Tyr Val Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ser Ser His Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Ala 
65                  70                  75                  80  


Phe Gly His Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Cys Glu Asn Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Val Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Ile His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Ala Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ala Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ser Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Met Tyr Glu Asp Asp Glu Glu Glu Ser Glu Ala Gln Gly 
        435                 440                 445             


Pro Lys 
    450 


<210>  7
<211>  1839
<212>  DNA
<213>  Homo sapiens

<400>  7
atcgccagtc tagcccactc cttcataaag ccctcgcatc ccaggagcga gcagagccag       60

agcaggatgg agaggagacg catcacctcc gctgctcgcc gctcctacgt ctcctcaggg      120

gagatgatgg tggggggcct ggctcctggc cgccgtctgg gtcctggcac ccgcctctcc      180

ctggctcgaa tgccccctcc actcccgacc cgggtggatt tctccctggc tggggcactc      240

aatgctggct tcaaggagac ccgggccagt gagcgggcag agatgatgga gctcaatgac      300

cgctttgcca gctacatcga gaaggttcgc ttcctggaac agcaaaacaa ggcgctggct      360

gctgagctga accagctgcg ggccaaggag cccaccaagc tggcagacgt ctaccaggct      420

gagctgcgag agctgcggct gcggctcgat caactcaccg ccaacagcgc ccggctggag      480

gttgagaggg acaatctggc acaggacctg gccactgtga ggcagaagct ccaggatgaa      540

accaacctga ggctggaagc cgagaacaac ctggctgcct atagacagga agcagatgaa      600

gccaccctgg cccgtctgga tctggagagg aagattgagt cgctggagga ggagatccgg      660

ttcttgagga agatccacga ggaggaggtt cgggaactcc aggagcagct ggcccgacag      720

caggtccatg tggagcttga cgtggccaag ccagacctca ccgcagccct gaaagagatc      780

cgcacgcagt atgaggcaat ggcgtccagc aacatgcatg aagccgaaga gtggtaccgc      840

tccaagtttg cagacctgac agacgctgct gcccgcaacg cggagctgct ccgccaggcc      900

aagcacgaag ccaacgacta ccggcgccag ttgcagtcct tgacctgcga cctggagtct      960

ctgcgcggca cgaacgagtc cctggagagg cagatgcgcg agcaggagga gcggcacgtg     1020

cgggaggcgg ccagttatca ggaggcgctg gcgcggctgg aggaagaggg gcagagcctc     1080

aaggacgaga tggcccgcca cttgcaggag taccaggacc tgctcaatgt caagctggcc     1140

ctggacatcg agatcgccac ctacaggaag ctgctagagg gcgaggagaa ccggatcacc     1200

attcccgtgc agaccttctc caacctgcag attcgagggg gcaaaagcac caaagacggg     1260

gaaaatcaca aggtcacaag atatctcaaa agcctcacaa tacgagttat accaatacag     1320

gctcaccaga ttgtaaatgg aacgccgccg gctcgcggtt agctgcctgc ctctcagaca     1380

cggcgctttg cccagcttga cagggagtga gcctcaccca ccccatcctc ccaatccccc     1440

tgagttccct cttcccaggc ttcccctaaa gggcctggac tgcgtcattt tcccaggaac     1500

tgcagtgccc agcccaggac gtggtacaga gtaactgtac attaaactgg cagagcttgt     1560

tagtggtaaa ggtggtgagt ccttgggtgc gcagtggagc tgctctgggg cctctgagca     1620

agcagcagcc tctgtctcac ctcttcctgt cactgggagg gccccttggg tctcgctgtg     1680

cctggacgcc aggctctctg ctttattctt tcatccctga ggctccatcg ctcagctcag     1740

tgctgactca gttcagagga ttcttccctc aggaccgcag ctcttgcagt gaataaagtt     1800

ttatgttccc tgctcttaat gttaaatatt aaaaaaaaa                            1839


<210>  8
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser 
385                 390                 395                 400 


Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg 
                405                 410                 415     


Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430         


<210>  9
<211>  1135
<212>  DNA
<213>  Homo sapiens

<400>  9
gggcagaggg aataagaggc tgcctctgcc caccagtcct gccgcccagg acccgcagca       60

gagacgacgc ctgcagcaag gagaccagga aggggtgaga caaggaagag gatgtctgag      120

ctggagaagg ccatggtggc cctcatcgac gttttccacc aatattctgg aagggaggga      180

gacaagcaca agctgaagaa atccgaactg aaggagctca tcaacaatga gctttcccat      240

ttcttagagg aaatcaaaga gcaggaggtt gtggacaaag tcatggaaac actggacaat      300

gatggagacg gcgaatgtga cttccaggaa ttcatggcct ttgttgccat ggttactact      360

gcctgccacg agttctttga acatgagtga gattagaaag cagccaaacc tttcctgtaa      420

cagagacggt catgcaagaa agcagacagc aagggcttgc agcctagtag gagctgagct      480

ttccagccgt gttgtagcta attaggaagc ttgatttgct ttgtgattga aaaattgaaa      540

acctctttcc aaaggctgtt ttaacggcct gcatcattct ttctgctata ttaggcctgt      600

gtgtaagctg actggcccca gggactcttg ttaacagtaa cttaggagtc aggtctcagt      660

gataaagcgt gcaccgtgca gcccgccatg gccgtgtaga ccctaacccg gagggaaccc      720

tgactacaga aattaccccg gggcaccctt aaaacttcca ctacctttaa aaaacaaagc      780

cttatccagc attatttgaa aacactgctg ttctttaaat gcgttcctca tccatgcaga      840

taacagctgg ttggccggtg tggccctgca agggcgtggt ggcttcggcc tgcttcccgg      900

gatgcgcctg atcaccaggt gaacgctcag cgctggcagc gctcctggaa aaagcaactc      960

catcagaact cgcaatccga gccagctctg ggggctccag cgtggcctcc gtgacccatg     1020

cgattcaagt cgcggctgca ggatccttgc ctccaacgtg cctccagcac atgcggcttc     1080

cgagggcact accgggggct ctgagccacc gcgagggcct gcgttcaata aaaag          1135


<210>  10
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His 
1               5                   10                  15      


Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu 
            20                  25                  30          


Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile 
        35                  40                  45              


Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp 
    50                  55                  60                  


Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met 
65                  70                  75                  80  


Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu 
                85                  90          


<210>  11
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210>  12
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Tyr Ser Met Met Met Glu Thr Asp Leu His Ser Pro Gly Gly Ala 
1               5                   10                  15      


Gln Ala Pro Thr Asn Leu Ser Gly Pro Ala Gly Ala Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Lys Ala Asn Gln 
        35                  40                  45              


Asp Arg Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Arg Gly 
    50                  55                  60                  


Gln Arg Arg Lys Met Ala Gln Glu Asn Pro Lys Met His Asn Ser Glu 
65                  70                  75                  80  


Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys Val Met Ser Glu Ala Glu 
                85                  90                  95      


Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg Leu Arg Ala Leu His Met 
            100                 105                 110         


Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Thr Lys Thr 
        115                 120                 125             


Leu Leu Lys Lys Asp Lys Tyr Ser Leu Ala Gly Gly Leu Leu Ala Ala 
    130                 135                 140                 


Gly Ala Gly Gly Gly Gly Ala Ala Val Ala Met Gly Val Gly Val Gly 
145                 150                 155                 160 


Val Gly Ala Ala Ala Val Gly Gln Arg Leu Glu Ser Pro Gly Gly Ala 
                165                 170                 175     


Ala Gly Gly Gly Tyr Ala His Val Asn Gly Trp Ala Asn Gly Ala Tyr 
            180                 185                 190         


Pro Gly Ser Val Ala Ala Ala Ala Ala Ala Ala Ala Met Met Gln Glu 
        195                 200                 205             


Ala Gln Leu Ala Tyr Gly Gln His Pro Gly Ala Gly Gly Ala His Pro 
    210                 215                 220                 


His Ala His Pro Ala His Pro His Pro His His Pro His Ala His Pro 
225                 230                 235                 240 


His Asn Pro Gln Pro Met His Arg Tyr Asp Met Gly Ala Leu Gln Tyr 
                245                 250                 255     


Ser Pro Ile Ser Asn Ser Gln Gly Tyr Met Ser Ala Ser Pro Ser Gly 
            260                 265                 270         


Tyr Gly Gly Leu Pro Tyr Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Gly Gly Ala His Gln Asn Ser Ala Val Ala Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ser Ser Gly Ala Leu Gly Ala Leu Gly Ser Leu Val Lys Ser 
305                 310                 315                 320 


Glu Pro Ser Gly Ser Pro Pro Ala Pro Ala His Ser Arg Ala Pro Cys 
                325                 330                 335     


Pro Gly Asp Leu Arg Glu Met Ile Ser Met Tyr Leu Pro Ala Gly Glu 
            340                 345                 350         


Gly Gly Asp Pro Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Arg Leu 
        355                 360                 365             


His Ser Leu Pro Gln His Tyr Gln Gly Ala Gly Ala Gly Val Asn Gly 
    370                 375                 380                 


Thr Val Pro Leu Thr His Ile 
385                 390     


<210>  13
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  14
<211>  1621
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Gly Cys Met Gly Glu Glu Ser Phe Gln Met Trp Glu Leu Asn 
1               5                   10                  15      


Arg Arg Leu Glu Ala Tyr Leu Ala Arg Val Lys Ala Leu Glu Glu Gln 
            20                  25                  30          


Asn Glu Leu Leu Ser Ala Glu Leu Gly Gly Leu Arg Ala Gln Ser Ala 
        35                  40                  45              


Asp Thr Ser Trp Arg Ala His Ala Asp Asp Glu Leu Ala Ala Leu Arg 
    50                  55                  60                  


Ala Leu Val Asp Gln Arg Trp Arg Glu Lys His Ala Ala Glu Val Ala 
65                  70                  75                  80  


Arg Asp Asn Leu Ala Glu Glu Leu Glu Gly Val Ala Gly Arg Cys Gln 
                85                  90                  95      


Gln Leu Arg Leu Ala Arg Glu Arg Thr Thr Glu Glu Val Ala Arg Asn 
            100                 105                 110         


Arg Arg Ala Val Glu Ala Glu Lys Cys Ala Arg Ala Trp Leu Ser Ser 
        115                 120                 125             


Gln Val Ala Glu Leu Glu Arg Glu Leu Glu Ala Leu Arg Val Ala His 
    130                 135                 140                 


Glu Glu Glu Arg Val Gly Leu Asn Ala Gln Ala Ala Cys Ala Pro Arg 
145                 150                 155                 160 


Cys Pro Ala Pro Pro Arg Gly Pro Pro Ala Pro Ala Pro Glu Val Glu 
                165                 170                 175     


Glu Leu Ala Arg Arg Leu Gly Glu Ala Trp Arg Gly Ala Val Arg Gly 
            180                 185                 190         


Tyr Gln Glu Arg Val Ala His Met Glu Thr Ser Leu Gly Gln Ala Arg 
        195                 200                 205             


Glu Arg Leu Gly Arg Ala Val Gln Gly Ala Arg Glu Gly Arg Leu Glu 
    210                 215                 220                 


Leu Gln Gln Leu Gln Ala Glu Arg Gly Gly Leu Leu Glu Arg Arg Ala 
225                 230                 235                 240 


Ala Leu Glu Gln Arg Leu Glu Gly Arg Trp Gln Glu Arg Leu Arg Ala 
                245                 250                 255     


Thr Glu Lys Phe Gln Leu Ala Val Glu Ala Leu Glu Gln Glu Lys Gln 
            260                 265                 270         


Gly Leu Gln Ser Gln Ile Ala Gln Val Leu Glu Gly Arg Gln Gln Leu 
        275                 280                 285             


Ala His Leu Lys Met Ser Leu Ser Leu Glu Val Ala Thr Tyr Arg Thr 
    290                 295                 300                 


Leu Leu Glu Ala Glu Asn Ser Arg Leu Gln Thr Pro Gly Gly Gly Ser 
305                 310                 315                 320 


Lys Thr Ser Leu Ser Phe Gln Asp Pro Lys Leu Glu Leu Gln Phe Pro 
                325                 330                 335     


Arg Thr Pro Glu Gly Arg Arg Leu Gly Ser Leu Leu Pro Val Leu Ser 
            340                 345                 350         


Pro Thr Ser Leu Pro Ser Pro Leu Pro Ala Thr Leu Glu Thr Pro Val 
        355                 360                 365             


Pro Ala Phe Leu Lys Asn Gln Glu Phe Leu Gln Ala Arg Thr Pro Thr 
    370                 375                 380                 


Leu Ala Ser Thr Pro Ile Pro Pro Thr Pro Gln Ala Pro Ser Pro Ala 
385                 390                 395                 400 


Val Asp Ala Glu Ile Arg Ala Gln Asp Ala Pro Leu Ser Leu Leu Gln 
                405                 410                 415     


Thr Gln Gly Gly Arg Lys Gln Ala Pro Glu Pro Leu Arg Ala Glu Ala 
            420                 425                 430         


Arg Val Ala Ile Pro Ala Ser Val Leu Pro Gly Pro Glu Glu Pro Gly 
        435                 440                 445             


Gly Gln Arg Gln Glu Ala Ser Thr Gly Gln Ser Pro Glu Asp His Ala 
    450                 455                 460                 


Ser Leu Ala Pro Pro Leu Ser Pro Asp His Ser Ser Leu Glu Ala Lys 
465                 470                 475                 480 


Asp Gly Glu Ser Gly Gly Ser Arg Val Phe Ser Ile Cys Arg Gly Glu 
                485                 490                 495     


Gly Glu Gly Gln Ile Trp Gly Leu Val Glu Lys Glu Thr Ala Ile Glu 
            500                 505                 510         


Gly Lys Val Val Ser Ser Leu Gln Gln Glu Ile Trp Glu Glu Glu Asp 
        515                 520                 525             


Leu Asn Arg Lys Glu Ile Gln Asp Ser Gln Val Pro Leu Glu Lys Glu 
    530                 535                 540                 


Thr Leu Lys Ser Leu Gly Glu Glu Ile Gln Glu Ser Leu Lys Thr Leu 
545                 550                 555                 560 


Glu Asn Gln Ser His Glu Thr Leu Glu Arg Glu Asn Gln Glu Cys Pro 
                565                 570                 575     


Arg Ser Leu Glu Glu Asp Leu Glu Thr Leu Lys Ser Leu Glu Lys Glu 
            580                 585                 590         


Asn Lys Glu Leu Leu Lys Asp Val Glu Val Val Arg Pro Leu Glu Lys 
        595                 600                 605             


Glu Ala Val Gly Gln Leu Lys Pro Thr Gly Lys Glu Asp Thr Gln Thr 
    610                 615                 620                 


Leu Gln Ser Leu Gln Lys Glu Asn Gln Glu Leu Met Lys Ser Leu Glu 
625                 630                 635                 640 


Gly Asn Leu Glu Thr Phe Leu Phe Pro Gly Thr Glu Asn Gln Glu Leu 
                645                 650                 655     


Val Ser Ser Leu Gln Glu Asn Leu Glu Ser Leu Thr Ala Leu Glu Lys 
            660                 665                 670         


Glu Asn Gln Glu Pro Leu Arg Ser Pro Glu Val Gly Asp Glu Glu Ala 
        675                 680                 685             


Leu Arg Pro Leu Thr Lys Glu Asn Gln Glu Pro Leu Arg Ser Leu Glu 
    690                 695                 700                 


Asp Glu Asn Lys Glu Ala Phe Arg Ser Leu Glu Lys Glu Asn Gln Glu 
705                 710                 715                 720 


Pro Leu Lys Thr Leu Glu Glu Glu Asp Gln Ser Ile Val Arg Pro Leu 
                725                 730                 735     


Glu Thr Glu Asn His Lys Ser Leu Arg Ser Leu Glu Glu Gln Asp Gln 
            740                 745                 750         


Glu Thr Leu Arg Thr Leu Glu Lys Glu Thr Gln Gln Arg Arg Arg Ser 
        755                 760                 765             


Leu Gly Glu Gln Asp Gln Met Thr Leu Arg Pro Pro Glu Lys Val Asp 
    770                 775                 780                 


Leu Glu Pro Leu Lys Ser Leu Asp Gln Glu Ile Ala Arg Pro Leu Glu 
785                 790                 795                 800 


Asn Glu Asn Gln Glu Phe Leu Lys Ser Leu Lys Glu Glu Ser Val Glu 
                805                 810                 815     


Ala Val Lys Ser Leu Glu Thr Glu Ile Leu Glu Ser Leu Lys Ser Ala 
            820                 825                 830         


Gly Gln Glu Asn Leu Glu Thr Leu Lys Ser Pro Glu Thr Gln Ala Pro 
        835                 840                 845             


Leu Trp Thr Pro Glu Glu Ile Asn Gln Gly Ala Met Asn Pro Leu Glu 
    850                 855                 860                 


Lys Glu Ile Gln Glu Pro Leu Glu Ser Val Glu Val Asn Gln Glu Thr 
865                 870                 875                 880 


Phe Arg Leu Leu Glu Glu Glu Asn Gln Glu Ser Leu Arg Ser Leu Gly 
                885                 890                 895     


Ala Trp Asn Leu Glu Asn Leu Arg Ser Pro Glu Glu Val Asp Lys Glu 
            900                 905                 910         


Ser Gln Arg Asn Leu Glu Glu Glu Glu Asn Leu Gly Lys Gly Glu Tyr 
        915                 920                 925             


Gln Glu Ser Leu Arg Ser Leu Glu Glu Glu Gly Gln Glu Leu Pro Gln 
    930                 935                 940                 


Ser Ala Asp Val Gln Arg Trp Glu Asp Thr Val Glu Lys Asp Gln Glu 
945                 950                 955                 960 


Leu Ala Gln Glu Ser Pro Pro Gly Met Ala Gly Val Glu Asn Glu Asp 
                965                 970                 975     


Glu Ala Glu Leu Asn Leu Arg Glu Gln Asp Gly Phe Thr Gly Lys Glu 
            980                 985                 990         


Glu Val Val Glu Gln Gly Glu Leu  Asn Ala Thr Glu Glu  Val Trp Ile 
        995                 1000                 1005             


Pro Gly  Glu Gly His Pro Glu  Ser Pro Glu Pro Lys  Glu Gln Arg 
    1010                 1015                 1020             


Gly Leu  Val Glu Gly Ala Ser  Val Lys Gly Gly Ala  Glu Gly Leu 
    1025                 1030                 1035             


Gln Asp  Pro Glu Gly Gln Ser  Gln Gln Val Gly Ala  Pro Gly Leu 
    1040                 1045                 1050             


Gln Ala  Pro Gln Gly Leu Pro  Glu Ala Ile Glu Pro  Leu Val Glu 
    1055                 1060                 1065             


Asp Asp  Val Ala Pro Gly Gly  Asp Gln Ala Ser Pro  Glu Val Met 
    1070                 1075                 1080             


Leu Gly  Ser Glu Pro Ala Met  Gly Glu Ser Ala Ala  Gly Ala Glu 
    1085                 1090                 1095             


Pro Gly  Pro Gly Gln Gly Val  Gly Gly Leu Gly Asp  Pro Gly His 
    1100                 1105                 1110             


Leu Thr  Arg Glu Glu Val Met  Glu Pro Pro Leu Glu  Glu Glu Ser 
    1115                 1120                 1125             


Leu Glu  Ala Lys Arg Val Gln  Gly Leu Glu Gly Pro  Arg Lys Asp 
    1130                 1135                 1140             


Leu Glu  Glu Ala Gly Gly Leu  Gly Thr Glu Phe Ser  Glu Leu Pro 
    1145                 1150                 1155             


Gly Lys  Ser Arg Asp Pro Trp  Glu Pro Pro Arg Glu  Gly Arg Glu 
    1160                 1165                 1170             


Glu Ser  Glu Ala Glu Ala Pro  Arg Gly Ala Glu Glu  Ala Phe Pro 
    1175                 1180                 1185             


Ala Glu  Thr Leu Gly His Thr  Gly Ser Asp Ala Pro  Ser Pro Trp 
    1190                 1195                 1200             


Pro Leu  Gly Ser Glu Glu Ala  Glu Glu Asp Val Pro  Pro Val Leu 
    1205                 1210                 1215             


Val Ser  Pro Ser Pro Thr Tyr  Thr Pro Ile Leu Glu  Asp Ala Pro 
    1220                 1225                 1230             


Gly Pro  Gln Pro Gln Ala Glu  Gly Ser Gln Glu Ala  Ser Trp Gly 
    1235                 1240                 1245             


Val Gln  Gly Arg Ala Glu Ala  Leu Gly Lys Val Glu  Ser Glu Gln 
    1250                 1255                 1260             


Glu Glu  Leu Gly Ser Gly Glu  Ile Pro Glu Gly Pro  Gln Glu Glu 
    1265                 1270                 1275             


Gly Glu  Glu Ser Arg Glu Glu  Ser Glu Glu Asp Glu  Leu Gly Glu 
    1280                 1285                 1290             


Thr Leu  Pro Asp Ser Thr Pro  Leu Gly Phe Tyr Leu  Arg Ser Pro 
    1295                 1300                 1305             


Thr Ser  Pro Arg Trp Asp Pro  Thr Gly Glu Gln Arg  Pro Pro Pro 
    1310                 1315                 1320             


Gln Gly  Glu Thr Gly Lys Glu  Gly Trp Asp Pro Ala  Val Leu Ala 
    1325                 1330                 1335             


Ser Glu  Gly Leu Glu Ala Pro  Pro Ser Glu Lys Glu  Glu Gly Glu 
    1340                 1345                 1350             


Glu Gly  Glu Glu Glu Cys Gly  Arg Asp Ser Asp Leu  Ser Glu Glu 
    1355                 1360                 1365             


Phe Glu  Asp Leu Gly Thr Glu  Ala Pro Phe Leu Pro  Gly Val Pro 
    1370                 1375                 1380             


Gly Glu  Val Ala Glu Pro Leu  Gly Gln Val Pro Gln  Leu Leu Leu 
    1385                 1390                 1395             


Asp Pro  Ala Ala Trp Asp Arg  Asp Gly Glu Ser Asp  Gly Phe Ala 
    1400                 1405                 1410             


Asp Glu  Glu Glu Ser Gly Glu  Glu Gly Glu Glu Asp  Gln Glu Glu 
    1415                 1420                 1425             


Gly Arg  Glu Pro Gly Ala Gly  Arg Trp Gly Pro Gly  Ser Ser Val 
    1430                 1435                 1440             


Gly Ser  Leu Gln Ala Leu Ser  Ser Ser Gln Arg Gly  Glu Phe Leu 
    1445                 1450                 1455             


Glu Ser  Asp Ser Val Ser Val  Ser Val Pro Trp Asp  Asp Ser Leu 
    1460                 1465                 1470             


Arg Gly  Ala Val Ala Gly Ala  Pro Lys Thr Ala Leu  Glu Thr Glu 
    1475                 1480                 1485             


Ser Gln  Asp Ser Ala Glu Pro  Ser Gly Ser Glu Glu  Glu Ser Asp 
    1490                 1495                 1500             


Pro Val  Ser Leu Glu Arg Glu  Asp Lys Val Pro Gly  Pro Leu Glu 
    1505                 1510                 1515             


Ile Pro  Ser Gly Met Glu Asp  Ala Gly Pro Gly Ala  Asp Ile Ile 
    1520                 1525                 1530             


Gly Val  Asn Gly Gln Gly Pro  Asn Leu Glu Gly Lys  Ser Gln His 
    1535                 1540                 1545             


Val Asn  Gly Gly Val Met Asn  Gly Leu Glu Gln Ser  Glu Glu Val 
    1550                 1555                 1560             


Gly Gln  Gly Met Pro Leu Val  Ser Glu Gly Asp Arg  Gly Ser Pro 
    1565                 1570                 1575             


Phe Gln  Glu Glu Glu Gly Ser  Ala Leu Lys Thr Ser  Trp Ala Gly 
    1580                 1585                 1590             


Ala Pro  Val His Leu Gly Gln  Gly Gln Phe Leu Lys  Phe Thr Gln 
    1595                 1600                 1605             


Arg Glu  Gly Asp Arg Glu Ser  Trp Ser Ser Gly Glu  Asp 
    1610                 1615                 1620     


<210>  15
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Leu Asp Gly Leu Lys Met Glu Glu Asn Phe Gln Ser Ala Ile Asp 
1               5                   10                  15      


Thr Ser Ala Ser Phe Ser Ser Leu Leu Gly Arg Ala Val Ser Pro Lys 
            20                  25                  30          


Ser Val Cys Glu Gly Cys Gln Arg Val Ile Leu Asp Arg Phe Leu Leu 
        35                  40                  45              


Arg Leu Asn Asp Ser Phe Trp His Glu Gln Cys Val Gln Cys Ala Ser 
    50                  55                  60                  


Cys Lys Glu Pro Leu Glu Thr Thr Cys Phe Tyr Arg Asp Lys Lys Leu 
65                  70                  75                  80  


Tyr Cys Lys Tyr Asp Tyr Glu Lys Leu Phe Ala Val Lys Cys Gly Gly 
                85                  90                  95      


Cys Phe Glu Ala Ile Ala Pro Asn Glu Phe Val Met Arg Ala Gln Lys 
            100                 105                 110         


Ser Val Tyr His Leu Ser Cys Phe Cys Cys Cys Val Cys Glu Arg Gln 
        115                 120                 125             


Leu Gln Lys Gly Asp Glu Phe Val Leu Lys Glu Gly Gln Leu Leu Cys 
    130                 135                 140                 


Lys Gly Asp Tyr Glu Lys Glu Arg Glu Leu Leu Ser Leu Val Ser Pro 
145                 150                 155                 160 


Ala Ala Ser Asp Ser Gly Lys Ser Asp Asp Glu Glu Ser Leu Cys Lys 
                165                 170                 175     


Ser Ala His Gly Ala Gly Lys Gly Thr Ala Glu Glu Gly Lys Asp His 
            180                 185                 190         


Lys Arg Pro Lys Arg Pro Arg Thr Ile Leu Thr Thr Gln Gln Arg Arg 
        195                 200                 205             


Ala Phe Lys Ala Ser Phe Glu Val Ser Ser Lys Pro Cys Arg Lys Val 
    210                 215                 220                 


Arg Glu Thr Leu Ala Ala Glu Thr Gly Leu Ser Val Arg Val Val Gln 
225                 230                 235                 240 


Val Trp Phe Gln Asn Gln Arg Ala Lys Met Lys Lys Leu Ala Arg Arg 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Asp Gln Gln Asn Thr Gln Arg Leu Ser Ser 
            260                 265                 270         


Ala Gln Thr Asn Gly Gly Gly Ser Ala Gly Met Glu Gly Ile Met Asn 
        275                 280                 285             


Pro Tyr Thr Ala Leu Pro Thr Pro Gln Gln Leu Leu Ala Ile Glu Gln 
    290                 295                 300                 


Ser Val Tyr Ser Ser Asp Pro Phe Arg Gln Gly Leu Thr Pro Pro Gln 
305                 310                 315                 320 


Met Pro Gly Asp His Met His Pro Tyr Gly Ala Glu Pro Leu Phe His 
                325                 330                 335     


Asp Leu Asp Ser Asp Asp Thr Ser Leu Ser Asn Leu Gly Asp Cys Phe 
            340                 345                 350         


Leu Ala Thr Ser Glu Ala Gly Pro Leu Gln Ser Arg Val Gly Asn Pro 
        355                 360                 365             


Ile Asp His Leu Tyr Ser Met Gln Asn Ser Tyr Phe Thr Ser 
    370                 375                 380         


<210>  16
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      


Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          


Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              


Ala Ala Met Gly Ser Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  


Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  


Ser Pro Gly Ala Gly Ala Met Ala Gly Met Gly Gly Ser Ala Gly Ala 
                85                  90                  95      


Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         


Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             


Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 


Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 


Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     


Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         


Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             


His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro 
    210                 215                 220                 


Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly 
225                 230                 235                 240 


Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys 
                245                 250                 255     


Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Gly Ser 
            260                 265                 270         


Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala Ser Gln Ala Gln Leu Gly 
        275                 280                 285             


Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser Pro 
    290                 295                 300                 


His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu Gly 
305                 310                 315                 320 


Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu Ser Pro Pro Glu Pro Ala 
                325                 330                 335     


Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly Pro 
            340                 345                 350         


Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu His 
        355                 360                 365             


His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser Ser 
    370                 375                 380                 


Glu Gln Gln His His His Ser His His His His Gln Pro His Lys Met 
385                 390                 395                 400 


Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Tyr Gly Ser 
                405                 410                 415     


Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys Thr Gly 
            420                 425                 430         


Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln Gly Val 
        435                 440                 445             


Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455         


<210>  17
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asp Ile Ala Thr Gly Pro Glu Ser Leu Glu Arg Cys Phe Pro Arg 
1               5                   10                  15      


Gly Gln Thr Asp Cys Ala Lys Met Leu Asp Gly Ile Lys Met Glu Glu 
            20                  25                  30          


His Ala Leu Arg Pro Gly Pro Ala Thr Leu Gly Val Leu Leu Gly Ser 
        35                  40                  45              


Asp Cys Pro His Pro Ala Val Cys Glu Gly Cys Gln Arg Pro Ile Ser 
    50                  55                  60                  


Asp Arg Phe Leu Met Arg Val Asn Glu Ser Ser Trp His Glu Glu Cys 
65                  70                  75                  80  


Leu Gln Cys Ala Ala Cys Gln Gln Ala Leu Thr Thr Ser Cys Tyr Phe 
                85                  90                  95      


Arg Asp Arg Lys Leu Tyr Cys Lys Gln Asp Tyr Gln Gln Leu Phe Ala 
            100                 105                 110         


Ala Lys Cys Ser Gly Cys Met Glu Lys Ile Ala Pro Thr Glu Phe Val 
        115                 120                 125             


Met Arg Ala Leu Glu Cys Val Tyr His Leu Gly Cys Phe Cys Cys Cys 
    130                 135                 140                 


Val Cys Glu Arg Gln Leu Arg Lys Gly Asp Glu Phe Val Leu Lys Glu 
145                 150                 155                 160 


Gly Gln Leu Leu Cys Lys Gly Asp Tyr Glu Lys Glu Lys Asp Leu Leu 
                165                 170                 175     


Ser Ser Val Ser Pro Asp Glu Ser Asp Ser Val Lys Ser Glu Asp Glu 
            180                 185                 190         


Asp Gly Asp Met Lys Pro Ala Lys Gly Gln Gly Ser Gln Ser Lys Gly 
        195                 200                 205             


Ser Gly Asp Asp Gly Lys Asp Pro Arg Arg Pro Lys Arg Pro Arg Thr 
    210                 215                 220                 


Ile Leu Thr Thr Gln Gln Arg Arg Ala Phe Lys Ala Ser Phe Glu Val 
225                 230                 235                 240 


Ser Ser Lys Pro Cys Arg Lys Val Arg Glu Thr Leu Ala Ala Glu Thr 
                245                 250                 255     


Gly Leu Ser Val Arg Val Val Gln Val Trp Phe Gln Asn Gln Arg Ala 
            260                 265                 270         


Lys Met Lys Lys Leu Ala Arg Arg His Gln Gln Gln Gln Glu Gln Gln 
        275                 280                 285             


Asn Ser Gln Arg Leu Gly Gln Glu Val Leu Ser Ser Arg Met Glu Gly 
    290                 295                 300                 


Met Met Ala Ser Tyr Thr Pro Leu Ala Pro Pro Gln Gln Gln Ile Val 
305                 310                 315                 320 


Ala Met Glu Gln Ser Pro Tyr Gly Ser Ser Asp Pro Phe Gln Gln Gly 
                325                 330                 335     


Leu Thr Pro Pro Gln Met Pro Gly Asp His Met Asn Pro Tyr Gly Asn 
            340                 345                 350         


Asp Ser Ile Phe His Asp Ile Asp Ser Asp Thr Ser Leu Thr Ser Leu 
        355                 360                 365             


Ser Asp Cys Phe Leu Gly Ser Ser Asp Val Gly Ser Leu Gln Ala Arg 
    370                 375                 380                 


Val Gly Asn Pro Ile Asp Arg Leu Tyr Ser Met Gln Ser Ser Tyr Phe 
385                 390                 395                 400 


Ala Ser 
        


<210>  18
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Thr Thr Pro Gly Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Glu Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


<210>  19
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Met Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
305                 310                 315                 320 


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
                325                 330                 335     


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
        355                 360                 365             


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
    370                 375                 380                 


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
385                 390                 395                 400 


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
                405                 410                 415     


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
            420                 425                 430         


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
        435                 440                 445             


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
    450                 455                 460                 


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
465                 470                 475                 480 


<210>  20
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Glu Gln Gln Pro Glu Pro Lys Ser Gln Arg Asp Ser Ala Leu 
1               5                   10                  15      


Gly Ala Ala Ala Ala Ala Thr Pro Gly Gly Leu Ser Leu Ser Leu Ser 
            20                  25                  30          


Pro Gly Ala Ser Gly Ser Ser Gly Ser Gly Ser Asp Gly Asp Ser Val 
        35                  40                  45              


Pro Val Ser Pro Gln Pro Ala Pro Pro Ser Pro Pro Ala Ala Pro Cys 
    50                  55                  60                  


Leu Pro Pro Leu Ala His His Pro His Leu Pro Pro His Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Gln His Leu Ala Ala Pro Ala His Gln Pro Gln Pro Ala 
                85                  90                  95      


Ala Gln Leu His Arg Thr Thr Asn Phe Phe Ile Asp Asn Ile Leu Arg 
            100                 105                 110         


Pro Asp Phe Gly Cys Lys Lys Glu Gln Pro Pro Pro Gln Leu Leu Val 
        115                 120                 125             


Ala Ala Ala Ala Arg Gly Gly Ala Gly Gly Gly Gly Arg Val Glu Arg 
    130                 135                 140                 


Asp Arg Gly Gln Thr Ala Ala Gly Arg Asp Pro Val His Pro Leu Gly 
145                 150                 155                 160 


Thr Arg Ala Pro Gly Ala Ala Ser Leu Leu Cys Ala Pro Asp Ala Asn 
                165                 170                 175     


Cys Gly Pro Pro Asp Gly Ser Gln Pro Ala Ala Ala Gly Ala Gly Ala 
            180                 185                 190         


Ser Lys Ala Gly Asn Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Pro Ser Asp Thr Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Ala Gly Ser Pro Gly Ala Gln Gly Thr 
225                 230                 235                 240 


Lys Tyr Pro Glu His Gly Asn Pro Ala Ile Leu Leu Met Gly Ser Ala 
                245                 250                 255     


Asn Gly Gly Pro Val Val Lys Thr Asp Ser Gln Gln Pro Leu Val Trp 
            260                 265                 270         


Pro Ala Trp Val Tyr Cys Thr Arg Tyr Ser Asp Arg Pro Ser Ser Gly 
        275                 280                 285             


Pro Arg Thr Arg Lys Leu Lys Lys Lys Lys Asn Glu Lys Glu Asp Lys 
    290                 295                 300                 


Arg Pro Arg Thr Ala Phe Thr Ala Glu Gln Leu Gln Arg Leu Lys Ala 
305                 310                 315                 320 


Glu Phe Gln Ala Asn Arg Tyr Ile Thr Glu Gln Arg Arg Gln Thr Leu 
                325                 330                 335     


Ala Gln Glu Leu Ser Leu Asn Glu Ser Gln Ile Lys Ile Trp Phe Gln 
            340                 345                 350         


Asn Lys Arg Ala Lys Ile Lys Lys Ala Thr Gly Ile Lys Asn Gly Leu 
        355                 360                 365             


Ala Leu His Leu Met Ala Gln Gly Leu Tyr Asn His Ser Thr Thr Thr 
    370                 375                 380                 


Val Gln Asp Lys Asp Glu Ser Glu 
385                 390         


