                         SEQUENCE LISTING

<110>  UNIVERSITE DE GENEVE
 
<120>  PERIOSTIN FRAGMENTS AND USE THEREOF

<130>  P1971PC00

<150>  US 62/238,901
<151>  2015-10-08

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 1

<400>  2

Gly Ser Leu Gln Pro Ile Ile Lys 
1               5               


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 2

<400>  3

Glu Glu Ile Glu Gly Lys Gly Ser Phe Thr 
1               5                   10  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 3

<400>  4

Thr Thr Gln Gly Ser Lys Ile Phe 
1               5               


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 4

<400>  5

Asn Glu Ala Phe Glu Lys Leu Pro Arg 
1               5                   


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 5

<400>  6

Gly Ser Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr 
1               5                   10              


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 6

<400>  7

Ser Glu Glu Lys Glu Ile Leu Ile Arg 
1               5                   


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 7

<400>  8

Ala Ala Asp Leu Lys Glu Leu Leu 
1               5               


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 8

<400>  9

Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
1               5                   10      


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 9

<400>  10

Thr Thr Gln Gly Ser Lys Ile Phe Leu 
1               5                   


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 10

<400>  11

Ser Ala Leu Arg Pro Asp Gly Glu Tyr Thr Leu Leu 
1               5                   10          


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 11

<400>  12

Glu Gly Glu Thr Ile Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys 
1               5                   10                  15      


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 12

<400>  13

Tyr Glu Cys Cys Pro Gly Tyr Met Arg 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 13

<400>  14

Ala Ala Asp Leu Lys Glu Leu Leu Thr 
1               5                   


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 14

<400>  15

Ile Gly Cys Asp Gly Asp Ser Ile Thr Val Asn Gly Ile Lys 
1               5                   10                  


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 15

<400>  16

Asn Asp Ala Phe Lys Gly Met Thr 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 16

<400>  17

Ala Glu Asp Asp Leu Ser Ser Phe Arg 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 17

<400>  18

Asp Thr Leu Leu Val Asn Glu Leu Lys 
1               5                   


<210>  19
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens CatK

<400>  19

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
1               5                   10                  15      


Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr 
            20                  25                  30          


His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu 
        35                  40                  45              


Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala 
    50                  55                  60                  


Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp 
65                  70                  75                  80  


Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val Pro 
                85                  90                  95      


Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp Glu 
            100                 105                 110         


Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr 
        115                 120                 125             


Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
    130                 135                 140                 


Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu 
145                 150                 155                 160 


Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly 
                165                 170                 175     


Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn 
            180                 185                 190         


Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu 
        195                 200                 205             


Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr 
    210                 215                 220                 


Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
225                 230                 235                 240 


Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe 
                245                 250                 255     


Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp 
            260                 265                 270         


Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly 
        275                 280                 285             


Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn 
    290                 295                 300                 


Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
305                 310                 315                 320 


Ala Asn Leu Ala Ser Phe Pro Lys Met 
                325                 


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control Peptide 1

<400>  20

Gly Ser Leu Gln Pro Ile Ile Lys Thr 
1               5                   


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control Peptide 2

<400>  21

Gly Ser Leu Gln Pro Ile Ile 
1               5           


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 18

<400>  22

Thr Asn Gly Val Val His Val Ile Asp Arg Val Leu Thr 
1               5                   10              


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 19

<400>  23

Thr Ser Ile Gln Asp Phe Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe 
1               5                   10                  15      


Arg 
    


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 20

<400>  24

Ala Thr Thr Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg 
1               5                   10                  


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Periostin fragment 21

<400>  25

Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg 
1               5                   10          


