﻿               SEQUENCE LISTING

<110> METAFORA Biosystems
      Centre National de la Recherche Scientifique
      Université de Montpellier
      Institut National de la Santé et de la Recherche Médicale
      TOUHAMI Jawida

<120> RECEPTOR-BINDING DOMAINS LIGANDS FOR THE DETECTION, DIAGNOSIS AND TREATMENT OF PANCREATIC CANCER

<130> CV - 547/PCT

<160> 55

<170> BiSSAP 1.3.6

<210> 1
<211> 189
<212> PRT
<213> Artificial Sequence


<220> 
<223> HERV-W.RBD

<400> 1
Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Val Ser Pro Ser 
1               5                   10                  15      
Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          
Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              
Ala Pro Ser Tyr Arg Ser Leu Cys Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  
His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  
His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      
Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         
Gly Met Ser Asp Gly Gly Gly Val Gln Asp Gln Ala Arg Glu Lys His 
        115                 120                 125             
Val Lys Glu Val Ile Ser Gln Leu Thr Arg Val His Gly Thr Ser Ser 
    130                 135                 140                 
Pro Tyr Lys Gly Leu Asp Leu Ser Lys Leu His Glu Thr Leu Arg Thr 
145                 150                 155                 160 
His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr Leu Thr Gly Leu His 
                165                 170                 175     
Glu Val Ser Ala Gln Asn Pro Thr Asn Cys Trp Ile Cys 
            180                 185                 

<210> 2
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> HERV-W.RBD

<400> 2
Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Leu Leu Pro Ser 
1               5                   10                  15      
Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          
Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              
Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  
His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  
His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      
Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         
Gly Met Ser Asp Gly Gly Gly Val Gln 
        115                 120     

<210> 3
<211> 363
<212> DNA
<213> Artificial Sequence


<220> 
<223> HERV-W.RBD

<400> 3
atggccctcc cttatcatat ttttctcttt actgttcttt taccctcttt cactctcact      60

gcaccccctc catgccgctg tatgaccagt agctcccctt accaagagtt tctatggaga     120

atgcagcgtc ccggaaatat tgatgcccca tcgtatagga gtctttctaa gggaaccccc     180

accttcactg cccacaccca tatgccccgc aactgctatc actctgccac tctttgcatg     240

catgcaaata ctcattattg gacaggaaaa atgattaatc ctagttgtcc tggaggactt     300

ggagtcactg tctgttggac ttacttcacc caaactggta tgtctgatgg gggtggagtt     360

caa                                                                   363


<210> 4
<211> 316
<212> PRT
<213> Artificial Sequence


<220> 
<223> Xeno.RBD

<400> 4
Met Leu Val Met Glu Gly Ser Ala Phe Ser Lys Pro Leu Lys Asp Lys 
1               5                   10                  15      
Ile Asn Pro Trp Gly Pro Leu Ile Val Met Gly Ile Leu Val Arg Ala 
            20                  25                  30          
Gly Ala Ser Val Gln Arg Asp Ser Pro His Gln Ile Phe Asn Val Thr 
        35                  40                  45              
Trp Arg Val Thr Asn Leu Met Thr Gly Gln Thr Ala Asn Ala Thr Ser 
    50                  55                  60                  
Leu Leu Gly Thr Met Thr Asp Thr Phe Pro Lys Leu Tyr Phe Asp Leu 
65                  70                  75                  80  
Cys Asp Leu Val Gly Asp Tyr Trp Asp Asp Pro Glu Pro Asp Ile Gly 
                85                  90                  95      
Asp Gly Cys Arg Thr Pro Gly Gly Arg Arg Arg Thr Arg Leu Tyr Asp 
            100                 105                 110         
Phe Tyr Val Cys Pro Gly His Thr Val Pro Ile Gly Cys Gly Gly Pro 
        115                 120                 125             
Gly Glu Gly Tyr Cys Gly Lys Trp Gly Cys Glu Thr Thr Gly Gln Ala 
    130                 135                 140                 
Tyr Trp Lys Pro Ser Ser Ser Trp Asp Leu Ile Ser Leu Lys Arg Gly 
145                 150                 155                 160 
Asn Thr Pro Lys Asp Gln Gly Pro Cys Tyr Asp Ser Ser Val Ser Ser 
                165                 170                 175     
Gly Val Gln Gly Ala Thr Pro Gly Gly Arg Cys Asn Pro Leu Val Leu 
            180                 185                 190         
Glu Phe Thr Asp Ala Gly Arg Lys Ala Ser Trp Asp Ala Pro Lys Val 
        195                 200                 205             
Trp Gly Leu Arg Leu Tyr Arg Ser Thr Gly Ala Asp Pro Val Thr Arg 
    210                 215                 220                 
Phe Ser Leu Thr Arg Gln Val Leu Asn Val Gly Pro Arg Val Pro Ile 
225                 230                 235                 240 
Gly Pro Asn Pro Val Ile Thr Asp Gln Leu Pro Pro Ser Gln Pro Val 
                245                 250                 255     
Gln Ile Met Leu Pro Arg Pro Pro His Pro Pro Pro Ser Gly Thr Val 
            260                 265                 270         
Ser Met Val Pro Gly Ala Pro Pro Pro Ser Gln Gln Pro Gly Thr Gly 
        275                 280                 285             
Asp Arg Leu Leu Asn Leu Val Glu Gly Ala Tyr Gln Ala Leu Asn Leu 
    290                 295                 300                 
Thr Ser Pro Asp Lys Thr Gln Glu Cys Trp Leu Cys 
305                 310                 315     

<210> 5
<211> 296
<212> PRT
<213> Artificial Sequence


<220> 
<223> Xeno.RBD

<400> 5
Met Leu Val Met Glu Gly Ser Ala Phe Ser Lys Pro Leu Lys Asp Lys 
1               5                   10                  15      
Ile Asn Pro Trp Gly Pro Leu Ile Val Met Gly Ile Leu Val Arg Ala 
            20                  25                  30          
Gly Ala Ser Val Gln Arg Asp Ser Pro His Gln Ile Phe Asn Val Thr 
        35                  40                  45              
Trp Arg Val Thr Asn Leu Met Thr Gly Gln Thr Ala Asn Ala Thr Ser 
    50                  55                  60                  
Leu Leu Gly Thr Met Thr Asp Thr Phe Pro Lys Leu Tyr Phe Asp Leu 
65                  70                  75                  80  
Cys Asp Leu Val Gly Asp Tyr Trp Asp Asp Pro Glu Pro Asp Ile Gly 
                85                  90                  95      
Asp Gly Cys Arg Thr Pro Gly Gly Arg Arg Arg Thr Arg Leu Tyr Asp 
            100                 105                 110         
Phe Tyr Val Cys Pro Gly His Thr Val Pro Ile Gly Cys Gly Gly Pro 
        115                 120                 125             
Gly Glu Gly Tyr Cys Gly Lys Trp Gly Cys Glu Thr Thr Gly Gln Ala 
    130                 135                 140                 
Tyr Trp Lys Pro Ser Ser Ser Trp Asp Leu Ile Ser Leu Lys Arg Gly 
145                 150                 155                 160 
Asn Thr Pro Lys Asp Gln Gly Pro Cys Tyr Asp Ser Ser Val Ser Ser 
                165                 170                 175     
Gly Val Gln Gly Ala Thr Pro Gly Gly Arg Cys Asn Pro Leu Val Leu 
            180                 185                 190         
Glu Phe Thr Asp Ala Gly Arg Lys Ala Ser Trp Asp Ala Pro Lys Val 
        195                 200                 205             
Trp Gly Leu Arg Leu Tyr Arg Ser Thr Gly Ala Asp Pro Val Thr Arg 
    210                 215                 220                 
Phe Ser Leu Thr Arg Gln Val Leu Asn Val Gly Pro Arg Val Pro Ile 
225                 230                 235                 240 
Gly Pro Asn Pro Val Ile Thr Asp Gln Leu Pro Pro Ser Gln Pro Val 
                245                 250                 255     
Gln Ile Met Leu Pro Arg Pro Pro His Pro Pro Pro Ser Gly Thr Val 
            260                 265                 270         
Ser Met Val Pro Gly Ala Pro Pro Pro Ser Gln Gln Pro Gly Thr Gly 
        275                 280                 285             
Asp Arg Leu Leu Asn Leu Val Gln 
    290                 295     

<210> 6
<211> 879
<212> DNA
<213> Artificial Sequence


<220> 
<223> Xeno.RBD

<400> 6
atggaaggtt cagcgttctc aaaacccctt aaagataaga ttaacccgtg gggcccccta      60

atagttatgg ggatcttggt gagggcagga gcctcggtac aacgtgacag ccctcaccag     120

atcttcaatg ttacttggag agttaccaac ctaatgacag gacaaacagc taacgccacc     180

tccctcctgg ggacgatgac agacaccttc cctaaactat attttgacct gtgtgattta     240

gtaggagact actgggatga cccagaaccc gatattgggg atggttgccg cactcccggg     300

ggaagaagaa ggacaagact gtatgacttc tatgtttgcc ccggtcatac tgtaccaata     360

gggtgtggag ggccgggaga gggctactgt ggcaaatggg gatgtgagac cactggacag     420

gcatactgga agccatcatc atcatgggac ctaatttccc ttaagcgagg aaacactcct     480

aaggatcagg gcccctgtta tgattcctcg gtctccagtg gcgtccaggg tgccacaccg     540

gggggtcgat gcaaccccct ggtcttagaa ttcactgacg cgggtagaaa ggccagctgg     600

gatgccccca aagtttgggg actaagactc tatcgatcca caggggccga cccggtgacc     660

cggttctctt tgacccgcca ggtcctcaat gtaggacccc gcgtccccat tgggcctaat     720

cccgtgatca ctgaccagct acccccatcc caacccgtgc agatcatgct ccccaggcct     780

cctcatcctc ctccttcagg cacggtctct atggtacctg gggctccccc gccttctcaa     840

caacctggga cgggagacag gctgctaaat ctggtagaa                            879


<210> 7
<211> 1059
<212> DNA
<213> Artificial Sequence


<220> 
<223> HERV-W.RBD fused to a mouse Fc fragment

<400> 7
atggccctcc cttatcatat ttttctcttt actgttcttt taccctcttt cactctcact      60

gcaccccctc catgccgctg tatgaccagt agctcccctt accaagagtt tctatggaga     120

atgcagcgtc ccggaaatat tgatgcccca tcgtatagga gtctttctaa gggaaccccc     180

accttcactg cccacaccca tatgccccgc aactgctatc actctgccac tctttgcatg     240

catgcaaata ctcattattg gacaggaaaa atgattaatc ctagttgtcc tggaggactt     300

ggagtcactg tctgttggac ttacttcacc caaactggta tgtctgatgg gggtggagtt     360

caaggatccg tcgacgtgcc cagggattgt ggttgtaagc cttgcatatg tacagtccca     420

gaagtatcat ctgtcttcat cttcccccca aagcccaagg atgtgctcac cattactctg     480

actcctaagg tcacgtgtgt tgtggtagac atcagcaagg atgatcccga ggtccagttc     540

agctggtttg tagatgatgt ggaggtgcac acagctcaga cgcaaccccg ggaggagcag     600

ttcaacagca ctttccgctc agtcagtgaa cttcccatca tgcaccagga ctggctcaat     660

ggcaaggagt tcaaatgcag ggtcaacagt gcagctttcc ctgcccccat cgagaaaacc     720

atctccaaaa ccaaaggcag accgaaggct ccacaggtgt acaccattcc acctcccaag     780

gagcagatgg ccaaggataa agtcagtctg acctgcatga taacagactt cttccctgaa     840

gacattactg tggagtggca gtggaatggg cagccagcgg agaactacaa gaacactcag     900

cccatcatgg acacagatgg ctcttacttc gtctacagca agctcaatgt gcagaagagc     960

aactgggagg caggaaatac tttcacctgc tctgtgttac atgagggcct gcacaaccac    1020

catactgaga agagcctctc ccactctcct ggtaaatga                           1059


<210> 8
<211> 1572
<212> DNA
<213> Artificial Sequence


<220> 
<223> Xeno.RBD fused to a rabbit Fc fragment

<400> 8
atggaaggtt cagcgttctc aaaacccctt aaagataaga ttaacccgtg gggcccccta      60

atagttatgg ggatcttggt gagggcagga gcctcggtac aacgtgacag ccctcaccag     120

atcttcaatg ttacttggag agttaccaac ctaatgacag gacaaacagc taacgccacc     180

tccctcctgg ggacgatgac agacaccttc cctaaactat attttgacct gtgtgattta     240

gtaggagact actgggatga cccagaaccc gatattgggg atggttgccg cactcccggg     300

ggaagaagaa ggacaagact gtatgacttc tatgtttgcc ccggtcatac tgtaccaata     360

gggtgtggag ggccgggaga gggctactgt ggcaaatggg gatgtgagac cactggacag     420

gcatactgga agccatcatc atcatgggac ctaatttccc ttaagcgagg aaacactcct     480

aaggatcagg gcccctgtta tgattcctcg gtctccagtg gcgtccaggg tgccacaccg     540

gggggtcgat gcaaccccct ggtcttagaa ttcactgacg cgggtagaaa ggccagctgg     600

gatgccccca aagtttgggg actaagactc tatcgatcca caggggccga cccggtgacc     660

cggttctctt tgacccgcca ggtcctcaat gtaggacccc gcgtccccat tgggcctaat     720

cccgtgatca ctgaccagct acccccatcc caacccgtgc agatcatgct ccccaggcct     780

cctcatcctc ctccttcagg cacggtctct atggtacctg gggctccccc gccttctcaa     840

caacctggga cgggagacag gctgctaaat ctggtagaag gatccgcacc ctcgacatgc     900

agcaagccca cgtgcccacc ccctgaactc ctggggggac cgtctgtctt catcttcccc     960

ccaaaaccca aggacaccct catgatctca cgcacccccg aggtcacatg cgtggtggtg    1020

gacgtgagcc aggatgaccc cgaggtgcag ttcacatggt acataaacaa cgagcaggtg    1080

cgcaccgccc ggccgccgct acgggagcag cagttcgact gcacgatccg cgtggtcagc    1140

accctcccca tcgcgcacca ggactggctg aggggcaagg agttcaagtg caaagtccac    1200

aacaaggcac tcccggcccc catcgagaaa accatctcca aagccagagg gcagcccctg    1260

gagccgaagg tctacaccat gggccctccc cgggaggagc tgagcagcag gtcggtcagc    1320

ctgacctgca tgatcaacgg cttctaccct tccgacatct cggtggagtg ggagaagaac    1380

gggaaggcag aggacaacta caagaccacg ccggccgtgc tggacagcga cggctcctac    1440

ttcctctaca gcaagctctc agtgcccacg agtgagtggc agcggggcga cgtcttcacc    1500

tgctccgtga tgcacgaggc cttgcacaac cactacacgc agaagtccat ctcccgctct    1560

ccgggtaaat ga                                                        1572


<210> 9
<211> 228
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rabbit Fc fragment

<400> 9
Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu 
1               5                   10                  15      
Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              
Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln 
    50                  55                  60                  
Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asp Cys Thr 
65                  70                  75                  80  
Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg 
                85                  90                  95      
Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys 
        115                 120                 125             
Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val 
    130                 135                 140                 
Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 
Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     
Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
            180                 185                 190         
Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg 
    210                 215                 220                 
Ser Pro Gly Lys 
225             

<210> 10
<211> 687
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rabbit Fc fragment

<400> 10
gcaccctcga catgcagcaa gcccacgtgc ccaccccctg aactcctggg gggaccgtct      60

gtcttcatct tccccccaaa acccaaggac accctcatga tctcacgcac ccccgaggtc     120

acatgcgtgg tggtggacgt gagccaggat gaccccgagg tgcagttcac atggtacata     180

aacaacgagc aggtgcgcac cgcccggccg ccgctacggg agcagcagtt caacagcacg     240

atccgcgtgg tcagcaccct ccccatcacg caccaggact ggctgagggg caaggagttc     300

aagtgcaaag tccacaacaa ggcactcccg gcccccatcg agaaaaccat ctccaaagcc     360

agagggcagc ccctggagcc gaaggtctac accatgggcc ctccccggga ggagctgagc     420

agcaggtcgg tcagcctgac ctgcatgatc aacggcttct acccttccga catctcggtg     480

gagtgggaga agaacgggaa ggcagaggac aactacaaga ccacgccggc cgtgctggac     540

agcgacggct cctacttcct ctacaacaag ctctcagtgc ccacgagtga gtggcagcgg     600

ggcgacgtct tcacctgctc cgtgatgcac gaggccttgc acaaccacta cacgcagaag     660

tccatctccc gctctccggg taaatga                                         687


<210> 11
<211> 229
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mouse Fc fragment

<400> 11
Val Asp Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
1               5                   10                  15      
Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
            20                  25                  30          
Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
        35                  40                  45              
Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
    50                  55                  60                  
Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  
Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
                85                  90                  95      
Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
            100                 105                 110         
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
        115                 120                 125             
Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
    130                 135                 140                 
Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
145                 150                 155                 160 
Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
                165                 170                 175     
Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
            180                 185                 190         
Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
        195                 200                 205             
Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
    210                 215                 220                 
His Ser Pro Gly Lys 
225                 

<210> 12
<211> 690
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mouse Fc fragment

<400> 12
gtcgacgtgc ccagggattg tggttgtaag ccttgcatat gtacagtccc agaagtatca      60

tctgtcttca tcttcccccc aaagcccaag gatgtgctca ccattactct gactcctaag     120

gtcacgtgtg ttgtggtaga catcagcaag gatgatcccg aggtccagtt cagctggttt     180

gtagatgatg tggaggtgca cacagctcag acgcaacccc gggaggagca gttcaacagc     240

actttccgct cagtcagtga acttcccatc atgcaccagg actggctcaa tggcaaggag     300

ttcaaatgca gggtcaacag tgcagctttc cctgccccca tcgagaaaac catctccaaa     360

accaaaggca gaccgaaggc tccacaggtg tacaccattc cacctcccaa ggagcagatg     420

gccaaggata aagtcagtct gacctgcatg ataacagact tcttccctga agacattact     480

gtggagtggc agtggaatgg gcagccagcg gagaactaca agaacactca gcccatcatg     540

gacacagatg gctcttactt cgtctacagc aagctcaatg tgcagaagag caactgggag     600

gcaggaaata ctttcacctg ctctgtgtta catgagggcc tgcacaacca ccatactgag     660

aagagcctct cccactctcc tggtaaatga                                      690


<210> 13
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human IL-2 peptide signal

<400> 13
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      
Val Thr Asn Ser 
            20  

<210> 14
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human albumin peptide signal

<400> 14
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      
Tyr Ser 
        

<210> 15
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human chymotrypsinogen peptide signal

<400> 15
Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      
Phe Gly 
        

<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human trypsinogen-2 peptide signal

<400> 16
Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  

<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Gaussia luciferase peptide signal

<400> 17
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      
Ala 
    

<210> 18
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mouse IgM peptide signal

<400> 18
Met Lys Phe Ser Trp Val Met Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      
Val Asn Ser Glu Phe 
            20      

<210> 19
<211> 532
<212> PRT
<213> Homo sapiens


<220> 
<223> ASCT1

<400> 19
Met Glu Lys Ser Asn Glu Thr Asn Gly Tyr Leu Asp Ser Ala Gln Ala 
1               5                   10                  15      
Gly Pro Ala Ala Gly Pro Gly Ala Pro Gly Thr Ala Ala Gly Arg Ala 
            20                  25                  30          
Arg Arg Cys Ala Gly Phe Leu Arg Arg Gln Ala Leu Val Leu Leu Thr 
        35                  40                  45              
Val Ser Gly Val Leu Ala Gly Ala Gly Leu Gly Ala Ala Leu Arg Gly 
    50                  55                  60                  
Leu Ser Leu Ser Arg Thr Gln Val Thr Tyr Leu Ala Phe Pro Gly Glu 
65                  70                  75                  80  
Met Leu Leu Arg Met Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys 
                85                  90                  95      
Ser Leu Val Ser Gly Ala Ala Ser Leu Asp Ala Ser Cys Leu Gly Arg 
            100                 105                 110         
Leu Gly Gly Ile Ala Val Ala Tyr Phe Gly Leu Thr Thr Leu Ser Ala 
        115                 120                 125             
Ser Ala Leu Ala Val Ala Leu Ala Phe Ile Ile Lys Pro Gly Ser Gly 
    130                 135                 140                 
Ala Gln Thr Leu Gln Ser Ser Asp Leu Gly Leu Glu Asp Ser Gly Pro 
145                 150                 155                 160 
Pro Pro Val Pro Lys Glu Thr Val Asp Ser Phe Leu Asp Leu Ala Arg 
                165                 170                 175     
Asn Leu Phe Pro Ser Asn Leu Val Val Ala Ala Phe Arg Thr Tyr Ala 
            180                 185                 190         
Thr Asp Tyr Lys Val Val Thr Gln Asn Ser Ser Ser Gly Asn Val Thr 
        195                 200                 205             
His Glu Lys Ile Pro Ile Gly Thr Glu Ile Glu Gly Met Asn Ile Leu 
    210                 215                 220                 
Gly Leu Val Leu Phe Ala Leu Val Leu Gly Val Ala Leu Lys Lys Leu 
225                 230                 235                 240 
Gly Ser Glu Gly Glu Asp Leu Ile Arg Phe Phe Asn Ser Leu Asn Glu 
                245                 250                 255     
Ala Thr Met Val Leu Val Ser Trp Ile Met Trp Tyr Val Pro Val Gly 
            260                 265                 270         
Ile Met Phe Leu Val Gly Ser Lys Ile Val Glu Met Lys Asp Ile Ile 
        275                 280                 285             
Val Leu Val Thr Ser Leu Gly Lys Tyr Ile Phe Ala Ser Ile Leu Gly 
    290                 295                 300                 
His Val Ile His Gly Gly Ile Val Leu Pro Leu Ile Tyr Phe Val Phe 
305                 310                 315                 320 
Thr Arg Lys Asn Pro Phe Arg Phe Leu Leu Gly Leu Leu Ala Pro Phe 
                325                 330                 335     
Ala Thr Ala Phe Ala Thr Cys Ser Ser Ser Ala Thr Leu Pro Ser Met 
            340                 345                 350         
Met Lys Cys Ile Glu Glu Asn Asn Gly Val Asp Lys Arg Ile Ser Arg 
        355                 360                 365             
Phe Ile Leu Pro Ile Gly Ala Thr Val Asn Met Asp Gly Ala Ala Ile 
    370                 375                 380                 
Phe Gln Cys Val Ala Ala Val Phe Ile Ala Gln Leu Asn Asn Val Glu 
385                 390                 395                 400 
Leu Asn Ala Gly Gln Ile Phe Thr Ile Leu Val Thr Ala Thr Ala Ser 
                405                 410                 415     
Ser Val Gly Ala Ala Gly Val Pro Ala Gly Gly Val Leu Thr Ile Ala 
            420                 425                 430         
Ile Ile Leu Glu Ala Ile Gly Leu Pro Thr His Asp Leu Pro Leu Ile 
        435                 440                 445             
Leu Ala Val Asp Trp Ile Val Asp Arg Thr Thr Thr Val Val Asn Val 
    450                 455                 460                 
Glu Gly Asp Ala Leu Gly Ala Gly Ile Leu His His Leu Asn Gln Lys 
465                 470                 475                 480 
Ala Thr Lys Lys Gly Glu Gln Glu Leu Ala Glu Val Lys Val Glu Ala 
                485                 490                 495     
Ile Pro Asn Cys Lys Ser Glu Glu Glu Thr Ser Pro Leu Val Thr His 
            500                 505                 510         
Gln Asn Pro Ala Gly Pro Val Ala Ser Ala Pro Glu Leu Glu Ser Lys 
        515                 520                 525             
Glu Ser Val Leu 
    530         

<210> 20
<211> 2102
<212> DNA
<213> Homo sapiens


<220> 
<223> ASCT1

<400> 20
cccgcactct gcgcctctcc tcgcctttct cgcacctgct cctgcgccag gcccggagac      60

ccccggggcg gcttcccaga acctgcggag cacaactggc cgaccgaccc attcattggg     120

aacccgtctt ttgccagagc ccacgtcccc tgccacctct agctcggagc ggcgtgtagc     180

gccatggaga agagcaacga gaccaacggc taccttgaca gcgctcaggc ggggcctgcg     240

gccgggcccg gagctccggg gaccgcggcg ggacgcgcac ggcgttgcgc gcgcttcctg     300

cggcgccaag cgctggtgct gctcaccgtg tccggggtgc tggcgggcgc gggcctgggc     360

gcggcgttgc gcgggctcag cctgagccgc acgcaggtca cctacctggc cttccccggc     420

gagatgctgc tccgcatgct gcgcatgatc atcctgccgc tggtggtctg cagcctggtg     480

tcgggcgccg cctcgctcga tgccagctgc ctcgggcgtc tgggcggcat ccgtgtcgcc     540

tactttggcc tcaccacact gagtgcctcg gcgctcgccg tggccttggc gttcatcatc     600

aagccaggat ccggtgcgca gacccttcag tccagcgacc tggggctgga ggactcgggg     660

cctcctcctg tccccaaaga gacggtggac tctttcctcg acctggccag aaacctgttt     720

ccctccaatc ttgtggttgc agctttccgt acgtatgcaa ccgattataa agtcgtgacc     780

cagaacagca gctctggaaa tgtaacccat gaaaagatcc ccataggcac tgagatagaa     840

gggatgaaca ttttaggatt ggtcctgttt gctctggtgt taggagtggc cttaaagaaa     900

ctaggctccg aaggagaaga cctcatccgt ttcttcaatt ccctcaacga ggcgacgatg     960

gtgctggtgt cctggattat gtggtacgta cctgtgggca tcatgttcct tgttggaagc    1020

aagatcgtgg aaatgaaaga catcatcgtg ctggtgacca gcctggggaa atacatcttc    1080

gcatctatat tgggccatgt tattcatgga ggaattgttc tgccacttat ttattttgtt    1140

ttcacacgaa aaaacccatt cagattcctc ctgggcctcc tcgccccatt tgcgacagca    1200

tttgctacct gctccagctc agcgaccctt ccctctatga tgaagtgcat tgaagagaac    1260

aatggtgtgg acaagaggat cagcaggttt attctcccca tcggggccac cgtgaacatg    1320

gacggagcag ccatcttcca gtgtgtggcc gcggtgttca ttgcgcaact caacaacata    1380

gagctcaacg caggacagat tttcaccatt ctagtgactg ccacagcgtc cagtgttgga    1440

gcagcaggcg tgccagctgg aggggtcctc accattgcca ttatcctgga ggccattggg    1500

ctgcctactc atgacctgcc tctgatcctg gctgtggact ggattgtgga ccggaccacc    1560

acggtggtga atgtggaagg ggatgccctg ggtgcaggca ttctccacca cctgaatcag    1620

aaggcaacaa agaaaggcga gcaggaactt gctgaggtga aagtggaagc catccccaac    1680

tgcaagtctg aggaggagac atcgcccctg gtgacacacc agaaccccgc tggccccgtg    1740

gccagtgccc cagaactgga atccaaggag tcggttctgt gatggggctg ggctttgggc    1800

ttgcctgcca gcagtgatgt cccaccctgt tcacccagcc gccagtcatg gacacagggc    1860

actgccttgc caacttttac cctcccaagc aatgctttgg cccagtcgct ggcctgaggc    1920

ttacctctcg gcactggcat tgggctcccc agccggaact ggttaccaag gacaaggaca    1980

ctctgacatt cggcttgatc catgtccagg tgcaactgtg tgtacaccag ggatctgttt    2040

ggaaacaacc ccttgagctg ccaggctcaa gaaatcatgg actcacaggg tcctgtgtgg    2100

tt                                                                   2102


<210> 21
<211> 631
<212> PRT
<213> Homo sapiens


<220> 
<223> XPR1

<400> 21
Met Lys Phe Ala Glu His Leu Ser Ala His Ile Thr Pro Glu Trp Arg 
1               5                   10                  15      
Lys Gln Tyr Ile Gln Tyr Glu Ala Phe Lys Asp Met Leu Tyr Ser Ala 
            20                  25                  30          
Gln Asp Gln Ala Pro Ser Val Glu Val Thr Asp Glu Asp Thr Val Lys 
        35                  40                  45              
Arg Tyr Phe Ala Lys Phe Glu Glu Lys Phe Phe Gln Thr Cys Glu Lys 
    50                  55                  60                  
Glu Leu Ala Lys Ile Asn Thr Phe Tyr Ser Glu Lys Leu Ala Glu Ala 
65                  70                  75                  80  
Gln Arg Arg Phe Ala Thr Leu Gln Asn Glu Leu Gln Ser Ser Leu Asp 
                85                  90                  95      
Ala Gln Lys Glu Ser Thr Gly Val Thr Thr Leu Arg Gln Arg Arg Lys 
            100                 105                 110         
Pro Val Phe His Leu Ser His Glu Glu Arg Val Gln His Arg Asn Ile 
        115                 120                 125             
Lys Asp Leu Lys Leu Ala Phe Ser Glu Phe Tyr Leu Ser Leu Ile Leu 
    130                 135                 140                 
Leu Gln Asn Tyr Gln Asn Leu Asn Phe Thr Gly Phe Arg Lys Ile Leu 
145                 150                 155                 160 
Lys Lys His Asp Lys Ile Leu Glu Thr Ser Arg Gly Ala Asp Trp Arg 
                165                 170                 175     
Val Ala His Val Glu Val Ala Pro Phe Tyr Thr Cys Lys Lys Ile Asn 
            180                 185                 190         
Gln Leu Ile Ser Glu Thr Glu Ala Val Val Thr Asn Glu Leu Glu Asp 
        195                 200                 205             
Gly Asp Arg Gln Lys Ala Met Lys Arg Leu Arg Val Pro Pro Leu Gly 
    210                 215                 220                 
Ala Ala Gln Pro Ala Pro Ala Trp Thr Thr Phe Arg Val Gly Leu Phe 
225                 230                 235                 240 
Cys Gly Ile Phe Ile Val Leu Asn Ile Thr Leu Val Leu Ala Ala Val 
                245                 250                 255     
Phe Lys Leu Glu Thr Asp Arg Ser Ile Trp Pro Leu Ile Arg Ile Tyr 
            260                 265                 270         
Arg Gly Gly Phe Leu Leu Ile Glu Phe Leu Phe Leu Leu Gly Ile Asn 
        275                 280                 285             
Thr Tyr Gly Trp Arg Gln Ala Gly Val Asn His Val Leu Ile Phe Glu 
    290                 295                 300                 
Leu Asn Pro Arg Ser Asn Leu Ser His Gln His Leu Phe Glu Ile Ala 
305                 310                 315                 320 
Gly Phe Leu Gly Ile Leu Trp Cys Leu Ser Leu Leu Ala Cys Phe Phe 
                325                 330                 335     
Ala Pro Ile Ser Val Ile Pro Thr Tyr Val Tyr Pro Leu Ala Leu Tyr 
            340                 345                 350         
Gly Phe Met Val Phe Phe Leu Ile Asn Pro Thr Lys Thr Phe Tyr Tyr 
        355                 360                 365             
Lys Ser Arg Phe Trp Leu Leu Lys Leu Leu Phe Arg Val Phe Thr Ala 
    370                 375                 380                 
Pro Phe His Lys Val Gly Phe Ala Asp Phe Trp Leu Ala Asp Gln Leu 
385                 390                 395                 400 
Asn Ser Leu Ser Val Ile Leu Met Asp Leu Glu Tyr Met Ile Cys Phe 
                405                 410                 415     
Tyr Ser Leu Glu Leu Lys Trp Asp Glu Ser Lys Gly Leu Leu Pro Asn 
            420                 425                 430         
Asn Ser Glu Glu Arg Gly His Ser Asp Thr Met Val Phe Phe Tyr Leu 
        435                 440                 445             
Trp Ile Val Phe Tyr Ile Ile Ser Ser Cys Tyr Thr Leu Ile Trp Asp 
    450                 455                 460                 
Leu Lys Met Asp Trp Gly Leu Phe Asp Lys Asn Ala Gly Glu Asn Thr 
465                 470                 475                 480 
Phe Leu Arg Glu Glu Ile Val Tyr Pro Gln Lys Ala Tyr Tyr Tyr Cys 
                485                 490                 495     
Ala Ile Ile Glu Asp Val Ile Leu Arg Phe Ala Trp Thr Ile Gln Ile 
            500                 505                 510         
Ser Ile Thr Ser Thr Thr Leu Leu Pro His Ser Gly Asp Ile Ile Ala 
        515                 520                 525             
Thr Val Phe Ala Pro Leu Glu Val Phe Arg Arg Phe Val Trp Asn Phe 
    530                 535                 540                 
Phe Arg Leu Glu Asn Glu His Leu Asn Asn Cys Gly Glu Phe Arg Ala 
545                 550                 555                 560 
Val Arg Asp Ile Ser Val Ala Pro Leu Asn Ala Asp Asp Gln Thr Leu 
                565                 570                 575     
Leu Glu Gln Met Met Asp Gln Asp Asp Gly Val Arg Asn Arg Gln Lys 
            580                 585                 590         
Asn Arg Ser Trp Lys Tyr Asn Gln Ser Ile Ser Leu Arg Arg Pro Arg 
        595                 600                 605             
Leu Ala Ser Gln Ser Lys Ala Arg Asp Thr Lys Val Leu Ile Glu Asp 
    610                 615                 620                 
Thr Asp Asp Glu Ala Asn Thr 
625                 630     

<210> 22
<211> 4154
<212> DNA
<213> Homo sapiens


<220> 
<223> XPR1

<400> 22
ggaggaagat ggcgggcggg ctgctctgaa gagacctcgg cggcggcgga ggaggagaga       60

agcgcagcgc cgcgccgcgc cggggcccat gtggggagga gtcggagtcg ctgttgccgc      120

cgccgcctgt agctgctgga cccgagtggg agtgaggggg aaacggcagg atgaagttcg      180

ccgagcacct ctccgcgcac atcactcccg agtggaggaa gcaatacatc cagtatgagg      240

ctttcaagga tatgctgtat tcagctcagg accaggcacc ttctgtggaa gttacagatg      300

aggacacagt aaagaggtat tttgccaagt ttgaagagaa gtttttccaa acctgtgaaa      360

aagaacttgc caaaatcaac acattttatt cagagaagct cgcagaggct cagcgcaggt      420

ttgctacact tcagaatgag cttcagtcat cactggatgc acagaaagaa agcactggtg      480

ttactacgct gcgacaacgc agaaagccag tcttccactt gtcccatgag gaacgtgtcc      540

aacatagaaa tattaaagac cttaaactgg ccttcagtga gttctacctc agtctaatcc      600

tgctgcagaa ctatcagaat ctgaatttta cagggtttcg aaaaatcctg aaaaagcatg      660

acaagatcct ggaaacatct cgtggagcag attggcgagt ggctcacgta gaggtggccc      720

cattttatac atgcaagaaa atcaaccagc ttatctctga aactgaggct gtagtgacca      780

atgaacttga agatggtgac agacaaaagg ctatgaagcg tttacgtgtc ccccctttgg      840

gagctgctca gcctgcacca gcatggacta cttttagagt tggcctattt tgtggaatat      900

tcattgtact gaatattacc cttgtgcttg ccgctgtatt taaacttgaa acagatagaa      960

gtatatggcc cttgataaga atctatcggg gtggctttct tctgattgaa ttcctttttc     1020

tactgggcat caacacgtat ggttggagac aggctggagt aaaccatgta ctcatctttg     1080

aacttaatcc gagaagcaat ttgtctcatc aacatctctt tgagattgct ggattcctcg     1140

ggatattgtg gtgcctgagc cttctggcat gcttctttgc tccaattagt gtcatcccca     1200

catatgtgta tccacttgcc ctttatggat ttatggtttt cttccttatc aaccccacca     1260

aaactttcta ctataaatcc cggttttggc tgcttaaact gctgtttcga gtatttacag     1320

cccccttcca taaggtaggc tttgctgatt tctggctggc ggatcagctg aacagcctgt     1380

cagtgatact gatggacctg gaatatatga tctgcttcta cagtttggag ctcaaatggg     1440

atgaaagtaa gggcctgttg ccaaataatt cagaagaacg aggtcactcg gacactatgg     1500

tgttctttta cctgtggatt gtcttttata tcatcagttc ctgctatacc ctcatctggg     1560

atctcaagat ggactggggt ctcttcgata agaatgctgg agagaacact ttcctccggg     1620

aagagattgt atacccccaa aaagcctact actactgtgc cataatagag gatgtgattc     1680

tgcgctttgc ttggactatc caaatctcga ttacctctac aactttgttg cctcattctg     1740

gggacatcat tgctactgtc tttgccccac ttgaggtttt ccggcgattt gtgtggaact     1800

tcttccgcct ggagaatgaa catctgaata actgtggtga attccgtgct gtgcgggaca     1860

tctctgtggc ccccctgaac gcagatgatc agactctcct agaacagatg atggaccagg     1920

atgatggggt acgaaaccgc cagaagaatc ggtcatggaa gtacaaccag agcatatccc     1980

tgcgccggcc tcgcctcgct tctcaatcca aggctcgtga cactaaggta ttgatagaag     2040

acacagatga tgaagctaac acttgaattt tctgaagtct agcttaacat ctttggtttt     2100

cctactctac aatcctttcc tcgaccaacg caacctctag tacctttcca gccgaaaaca     2160

ggagaaaaca cataacacat tttccgagct cttccggatc ggatcctatg gactccaaac     2220

aagctcactg tgtttctttt cttttcttct ggtttaattt taattttcta ttttcaaaac     2280

aaatatttac ttcatttgcc aatcagagga tgttttaaga aacaaaacat agtatcttat     2340

ggattgttta caatcacaag gacatagata cctatcagga tgaagaacag gcattgcaag     2400

gaccctctga tgggacggta ctgagatatc tcggcttccg ctcagcccgg ttttgactgg     2460

ttgaaaccgg acattggttt ttaaattttt tgtcagttta tgtggagaat ttttttcttt     2520

ccttcatacc cagcgcaaag gcactggccg cacttgcagg aaaagtgcaa cttaaagcag     2580

taccttcatt catgaagcta ctttttaatt tgatgtaact tttcttattt tgggaagggt     2640

tgctgggtgg gtgggaaata tgatgtattt gttacacata gttttctcat tatttatgaa     2700

acttaaccat acagaatgat ataactcctg tgcaatgaag gtgataacag taaaagaagg     2760

caggggaaac ttacgttgga tgacatttat gagggtcagt cccacatacc tctttcagga     2820

gacaacttgc accagtttga ccttttcttt tctttgtttt tattttaagc caaagtttca     2880

ttgctaactt cttaagttgc tgctgcttta gagtcctgag catatctctc gtaacaagga     2940

atcccacact tcacaccacc ggctgaattt catggaagag gttctgataa tttttttaac     3000

tttttaagga acagatgtgg aatacactgg cccatatttc aaccttaaca gctgaagcta     3060

tgccttatta tgcatccaca tgtatggtcc ctgtagcgtg acctttacta gctctgaatc     3120

agaagacaga gctatttcag aggctctgtg tgccctcact agatagtttt tcttctgggt     3180

tcaaccactt tagccagaat ttgatcaaat taaaagtctg tcatggggaa actatatttt     3240

tgagcacatg gaacaaatta tacttcctca ttcatattat gttgatacaa aagaccttgg     3300

cagccatttc tcccagcagt tttaaaggat gaacattgga tttcatgcca tcccatagaa     3360

aacctgtttt aaaattttag ggatctttac ttggtcatac atgaaaagta cactgcttag     3420

aaattataga ctattatgat ctgtccacag tgcccattgt cacttctttg tctcatttct     3480

tccctttgtt ccttagtcat ccaaataagc ctgaaaacca taagagatat tactttattg     3540

aatatggttg gcattaaatt tagcatttca ttatctaaca aaattaatat aaattccagg     3600

acatggtaaa atgtgtttta ataaccccca gacccaaatg aaaatttcaa agtcaatacc     3660

agcagattca tgaaagtaaa tttagtccta taattttcag cttaattata aacaaaggaa     3720

caaataagtg gaagggcagc tattaccatt cgcttagtca aaacattcgg ttactgccct     3780

ttaatacact cctatcatca gcacttccac catgtattac aagtcttgac ccatccctgt     3840

cgtaactcca gtaaaagtta ctgttactag aaaattttta tcaattaact gacaaatagt     3900

ttctttttaa agtagtttct tccatcttta ttctgactag cttccaaaat gtgttccctt     3960

tttgaatcga ggtttttttg ttttgttttg ttttctgaaa aaatcataca actttgtgct     4020

tctattgctt ttttgtgttt tgttaagcat gtcccttggc ccaaatggaa gaggaaatgt     4080

ttaattaatg ctttttagtt taaataaatt gaatcattta taataaaaaa aaaaaaaaaa     4140

aaaaaaaaaa aaaa                                                       4154


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> XPR1 PCR forward primer

<400> 23
agagcttggg agacaaagca                                                20


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> XPR1 PCR reverse primer

<400> 24
gtggacacaa cattcgcaac                                                20


<210> 25
<211> 17
<212> DNA
<213> Artificial Sequence


<220> 
<223> ASCT2 PCR forward primer

<400> 25
atcgtggaga tggagga                                                   17


<210> 26
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> ASCT2 PCR reverse primer

<400> 26
aagaggtccc aaaggcag                                                  18


<210> 27
<211> 693
<212> DNA
<213> Artificial Sequence


<220> 
<223> Human IgG2 Fc fragment

<400> 27
atatcggcca tggttagatc tgtggagtgc ccaccgtgcc cagcaccacc tgtggcagga      60

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     120

gaggtcacgt gcgtggtggt ggacgtgagc cacgaagacc ccgaggtcca gttcaactgg     180

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cacgggagga gcagttcaac     240

agcacgttcc gtgtggtcag cgtcctcacc gttgtgcacc aggactggct gaacggcaag     300

gagtacaagt gcaaggtctc caacaaaggc ctcccagccc ccatcgagaa aaccatctcc     360

aaaaccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     420

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc     480

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac acctcccatg     540

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     600

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     660

cagaagagcc tctccctgtc tccgggtaaa tga                                  693


<210> 28
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> RD114.RBD

<400> 28
Met Lys Leu Pro Thr Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      
Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          
Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              
Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  
Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Ile Ser 
65                  70                  75                  80  
Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln Asp 
                85                  90                  95      
Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Arg Ile 
            100                 105                 110         
Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly Ser 
        115                 120                 125             
Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln Ser 
    130                 135                 140                 
Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr Ala 
145                 150                 155                 160 
Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg Val 
                165                 170                 175     
Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met Thr Pro 
            180                 185                 190         
Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp Leu 
        195                 200                 205             
Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe Arg Leu 
    210                 215                 220                 
Leu Gln Met Ser Asn Phe Ser Leu Ala Gln Asp Cys Trp Leu Cys 
225                 230                 235                 

<210> 29
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> RD114.RBD

<400> 29
Met Lys Leu Pro Thr Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      
Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          
Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              
Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  
Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Ile Ser 
65                  70                  75                  80  
Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln Asp 
                85                  90                  95      
Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Arg Ile 
            100                 105                 110         
Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly Ser 
        115                 120                 125             
Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln Ser 
    130                 135                 140                 
Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr Ala 
145                 150                 155                 160 
Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg Val 
                165                 170                 175     
Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met Thr Pro 
            180                 185                 190         
Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp Leu 
        195                 200                 205             
Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe 
    210                 215                 220         

<210> 30
<211> 669
<212> DNA
<213> Artificial Sequence


<220> 
<223> RD114.RBD

<400> 30
atgaaactcc cagcaggaat ggtcatttta tgtagcctaa taatagttcg ggcagggttt      60

gacgaccccc gcaaggctat cgcattagta caaaaacaac atggtaaacc atgcgaatgc     120

agcggagggc aggtatccga ggccccaccg aactccatcc aacaggtaac ttgcccaggc     180

aagacggcct acttaatgac caaccaaaaa tggaaatgca gagtcactcc aaaaaatctc     240

acccctagcg ggggagaact ccagaactgc ccctgtaaca ctttccagga ctcgatgcac     300

agttcttgtt atactgaata ccggcaatgc agggcgaata ataagacata ctacacggcc     360

accttgctta aaatacggtc tgggagcctc aacgaggtac agatattaca aaaccccaat     420

cagctcctac agtccccttg taggggctct ataaatcagc ccgtttgctg gagtgccaca     480

gcccccatcc atatctccga tggtggagga cccctcgata ctaagagagt gtggacagtc     540

caaaaaaggc tagaacaaat tcataaggct atgcatcctg aacttcaata ccacccctta     600

gccctgccca aagtcagaga tgaccttagc cttgatgcac ggacttttga tatcctgaat     660

accactttt                                                             669


<210> 31
<211> 1365
<212> DNA
<213> Artificial Sequence


<220> 
<223> RD114.RBD fused to a mouse Fc fragment

<400> 31
atgaaactcc cagcaggaat ggtcatttta tgtagcctaa taatagttcg ggcagggttt      60

gacgaccccc gcaaggctat cgcattagta caaaaacaac atggtaaacc atgcgaatgc     120

agcggagggc aggtatccga ggccccaccg aactccatcc aacaggtaac ttgcccaggc     180

aagacggcct acttaatgac caaccaaaaa tggaaatgca gagtcactcc aaaaaatctc     240

acccctagcg ggggagaact ccagaactgc ccctgtaaca ctttccagga ctcgatgcac     300

agttcttgtt atactgaata ccggcaatgc agggcgaata ataagacata ctacacggcc     360

accttgctta aaatacggtc tgggagcctc aacgaggtac agatattaca aaaccccaat     420

cagctcctac agtccccttg taggggctct ataaatcagc ccgtttgctg gagtgccaca     480

gcccccatcc atatctccga tggtggagga cccctcgata ctaagagagt gtggacagtc     540

caaaaaaggc tagaacaaat tcataaggct atgcatcctg aacttcaata ccacccctta     600

gccctgccca aagtcagaga tgaccttagc cttgatgcac ggacttttga tatcctgaat     660

accacttttg gatccgtcga cgtgcccagg gattgtggtt gtaagccttg catatgtaca     720

gtcccagaag tatcatctgt cttcatcttc cccccaaagc ccaaggatgt gctcaccatt     780

actctgactc ctaaggtcac gtgtgttgtg gtagacatca gcaaggatga tcccgaggtc     840

cagttcagct ggtttgtaga tgatgtggag gtgcacacag ctcagacgca accccgggag     900

gagcagttca acagcacttt ccgctcagtc agtgaacttc ccatcatgca ccaggactgg     960

ctcaatggca aggagttcaa atgcagggtc aacagtgcag ctttccctgc ccccatcgag    1020

aaaaccatct ccaaaaccaa aggcagaccg aaggctccac aggtgtacac cattccacct    1080

cccaaggagc agatggccaa ggataaagtc agtctgacct gcatgataac agacttcttc    1140

cctgaagaca ttactgtgga gtggcagtgg aatgggcagc cagcggagaa ctacaagaac    1200

actcagccca tcatggacac agatggctct tacttcgtct acagcaagct caatgtgcag    1260

aagagcaact gggaggcagg aaatactttc acctgctctg tgttacatga gggcctgcac    1320

aaccaccata ctgagaagag cctctcccac tctcctggta aatga                    1365


<210> 32
<211> 224
<212> PRT
<213> Artificial Sequence


<220> 
<223> H2.RBD

<400> 32
Met Gly Asn Val Phe Phe Leu Leu Leu Phe Ser Leu Thr His Phe Pro 
1               5                   10                  15      
Leu Ala Gln Gln Ser Arg Cys Thr Leu Thr Val Gly Ile Ser Ser Tyr 
            20                  25                  30          
His Ser Ser Pro Cys Ser Pro Thr Gln Pro Val Cys Thr Trp Asn Leu 
        35                  40                  45              
Asp Leu Asn Ser Leu Thr Thr Asp Gln Arg Leu His Pro Pro Cys Pro 
    50                  55                  60                  
Asn Leu Ile Thr Tyr Ser Gly Phe His Lys Thr Tyr Ser Leu Tyr Leu 
65                  70                  75                  80  
Phe Pro His Trp Ile Lys Lys Pro Asn Arg Gln Gly Leu Gly Tyr Tyr 
                85                  90                  95      
Ser Pro Ser Tyr Asn Asp Pro Cys Ser Leu Gln Cys Pro Tyr Leu Gly 
            100                 105                 110         
Cys Gln Ser Trp Thr Cys Pro Tyr Thr Gly Pro Val Ser Ser Pro Ser 
        115                 120                 125             
Trp Lys Phe His Ser Asp Val Asn Phe Thr Gln Glu Val Ser Gln Val 
    130                 135                 140                 
Ser Leu Arg Leu His Phe Ser Lys Cys Gly Ser Ser Met Thr Leu Leu 
145                 150                 155                 160 
Val Asp Ala Pro Gly Tyr Asp Pro Leu Trp Phe Ile Thr Ser Glu Pro 
                165                 170                 175     
Thr Gln Pro Pro Pro Thr Ser Pro Pro Leu Val His Asp Ser Asp Leu 
            180                 185                 190         
Glu His Val Leu Thr Pro Ser Thr Ser Trp Thr Thr Lys Ile Leu Lys 
        195                 200                 205             
Phe Ile Gln Leu Thr Leu Gln Ser Thr Asn Tyr Ser Cys Met Val Cys 
    210                 215                 220                 



<210> 33
<211> 541
<212> PRT
<213> Homo sapiens


<220> 
<223> ASCT2

<400> 33
Met Val Ala Asp Pro Pro Arg Asp Ser Lys Gly Leu Ala Ala Ala Glu 
1               5                   10                  15      
Pro Thr Ala Asn Gly Gly Leu Ala Leu Ala Ser Ile Glu Asp Gln Gly 
            20                  25                  30          
Ala Ala Ala Gly Gly Tyr Cys Gly Ser Arg Asp Gln Val Arg Arg Cys 
        35                  40                  45              
Leu Arg Ala Asn Leu Leu Val Leu Leu Thr Val Val Ala Val Val Ala 
    50                  55                  60                  
Gly Val Ala Leu Gly Leu Gly Val Ser Gly Ala Gly Gly Ala Leu Ala 
65                  70                  75                  80  
Leu Gly Pro Glu Arg Leu Ser Ala Phe Val Phe Pro Gly Glu Leu Leu 
                85                  90                  95      
Leu Arg Leu Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys Ser Leu 
            100                 105                 110         
Ile Gly Gly Ala Ala Ser Leu Asp Pro Gly Ala Leu Gly Arg Leu Gly 
        115                 120                 125             
Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser Ala 
    130                 135                 140                 
Leu Gly Val Gly Leu Ala Leu Ala Leu Gln Pro Gly Ala Ala Ser Ala 
145                 150                 155                 160 
Ala Ile Asn Ala Ser Val Gly Ala Ala Gly Ser Ala Glu Asn Ala Pro 
                165                 170                 175     
Ser Lys Glu Val Leu Asp Ser Phe Leu Asp Leu Ala Arg Asn Ile Phe 
            180                 185                 190         
Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Tyr Ser Thr Thr Tyr 
        195                 200                 205             
Glu Glu Arg Asn Ile Thr Gly Thr Arg Val Lys Val Pro Val Gly Gln 
    210                 215                 220                 
Glu Val Glu Gly Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val 
225                 230                 235                 240 
Phe Gly Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile 
                245                 250                 255     
Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp 
            260                 265                 270         
Ile Met Trp Tyr Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys 
        275                 280                 285             
Ile Val Glu Met Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys 
    290                 295                 300                 
Tyr Ile Leu Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val 
305                 310                 315                 320 
Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe 
                325                 330                 335     
Leu Trp Gly Ile Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser 
            340                 345                 350         
Ser Ser Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn 
        355                 360                 365             
Gly Val Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr 
    370                 375                 380                 
Val Asn Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe 
385                 390                 395                 400 
Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr 
                405                 410                 415     
Ile Leu Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro 
            420                 425                 430         
Ala Gly Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu 
        435                 440                 445             
Pro Val Asp His Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp 
    450                 455                 460                 
Arg Ser Cys Thr Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly 
465                 470                 475                 480 
Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro 
                485                 490                 495     
Glu Leu Ile Gln Val Lys Ser Glu Leu Pro Leu Asp Pro Leu Pro Val 
            500                 505                 510         
Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala 
        515                 520                 525             
Gly Asp Ala Thr Val Ala Ser Glu Lys Glu Ser Val Met 
    530                 535                 540     

<210> 34
<211> 1626
<212> DNA
<213> Homo sapiens


<220> 
<223> ASCT2

<400> 34
atggtggccg atcctcctcg agactccaag gggctcgcag cggcggagcc caccgccaac      60

gggggcctgg cgctggcctc catcgaggac caaggcgcgg cagcaggcgg ctactgcggt     120

tcccgggacc aggtgcgccg ctgccttcga gccaacctgc ttgtgctgct gacagtggtg     180

gccgtggtgg ccggcgtggc gctgggactg ggggtgtcgg gggccggggg tgcgctggcg     240

ttgggcccgg agcgcttgag cgccttcgtc ttcccgggcg agctgctgct gcgtctgctg     300

cggatgatca tcttgccgct ggtggtgtgc agcttgatcg gcggcgccgc cagcctggac     360

cccggcgcgc tcggccgtct gggcgcctgg gcgctgctct ttttcctggt caccacgctg     420

ctggcgtcgg cgctcggagt gggcttggcg ctggctctgc agccgggcgc cgcctccgcc     480

gccatcaacg cctccgtggg agccgcgggc agtgccgaaa atgcccccag caaggaggtg     540

ctcgattcgt tcctggatct tgcgagaaat atcttccctt ccaacctggt gtcagcagcc     600

tttcgctcat actctaccac ctatgaagag aggaatatca ccggaaccag ggtgaaggtg     660

cccgtggggc aggaggtgga ggggatgaac atcctgggct tggtagtgtt tgccatcgtc     720

tttggtgtgg cgctgcggaa gctggggcct gaaggggagc tgcttatccg cttcttcaac     780

tccttcaatg aggccaccat ggttctggtc tcctggatca tgtggtatgc ccctgtgggc     840

atcatgttcc tggtggctgg caagatcgtg gagatggagg atgtgggttt actctttgcc     900

cgccttggca agtacattct gtgctgcctg ctgggtcacg ccatccatgg gctcctggta     960

ctgcccctca tctacttcct cttcacccgc aaaaacccct accgcttcct gtggggcatc    1020

gtgacgccgc tggccactgc ctttgggacc tcttccagtt ccgccacgct gccgctgatg    1080

atgaagtgcg tggaggagaa taatggcgtg gccaagcaca tcagccgttt catcctgccc    1140

atcggcgcca ccgtcaacat ggacggtgcc gcgctcttcc agtgcgtggc cgcagtgttc    1200

attgcacagc tcagccagca gtccttggac ttcgtaaaga tcatcaccat cctggtcacg    1260

gccacagcgt ccagcgtggg ggcagcgggc atccctgctg gaggtgtcct cactctggcc    1320

atcatcctcg aagcagtcaa cctcccggtc gaccatatct ccttgatcct ggctgtggac    1380

tggctagtcg accggtcctg taccgtcctc aatgtagaag gtgacgctct gggggcagga    1440

ctcctccaaa attacgtgga ccgtacggag tcgagaagca cagagcctga gttgatacaa    1500

gtgaagagtg agctgcccct ggatccgctg ccagtcccca ctgaggaagg aaaccccctc    1560

ctcaaacact atcgggggcc cgcaggggat gccacggtcg cctctgagaa ggaatcagtc    1620

atgtaa                                                               1626


<210> 35
<211> 331
<212> PRT
<213> Artificial Sequence


<220> 
<223> RD114.RBD

<400> 35
Met Lys Pro Pro Ala Gly Met Val Phe Leu Trp Val Leu Thr Ser Leu 
1               5                   10                  15      
Gly Ala Gly Ile Gly Ala Lys Ile Val Lys Glu Gly Asn Pro His Gln 
            20                  25                  30          
Val Tyr Thr Leu Thr Trp Gln Ile Tyr Ser Gln Ser Gly Glu Val Val 
        35                  40                  45              
Trp Glu Val Gln Gly Asn His Ala Leu Asn Thr Trp Trp Pro Pro Leu 
    50                  55                  60                  
Thr Pro Asp Phe Cys Gln Leu Ala Ala Gly Leu Asp Thr Trp Asp Ile 
65                  70                  75                  80  
Pro Ala Arg Ser Pro Lys Asn Leu Gln Ser Tyr Met Gly Glu Arg Ile 
                85                  90                  95      
Gln Gln Met Thr Ala His Gly Cys Ser Ser Pro Thr Ala Arg Cys Arg 
            100                 105                 110         
Leu Ala Gln Ala Glu Phe Tyr Val Cys Pro Arg Asp Asn Arg Asp Arg 
        115                 120                 125             
Ala Thr Ala His Arg Cys Gly Gly Tyr Glu Glu Tyr Phe Cys Ser Ala 
    130                 135                 140                 
Trp Gly Cys Glu Thr Thr Gly Asp Ala Tyr Trp Gln Pro Thr Ser Ser 
145                 150                 155                 160 
Trp Asp Leu Ile Thr Ile Thr Arg Gly Tyr Thr Lys Pro Asp Pro Asp 
                165                 170                 175     
Gly His Thr Cys Tyr Tyr Lys Lys Gly Thr Glu Gly Tyr His His Trp 
            180                 185                 190         
Ile Ser Pro Leu Ser Leu Pro Leu Lys Ile Thr Phe Thr Asp Ser Gly 
        195                 200                 205             
Lys Arg Ala Leu Gly Trp Gln Thr Gly Tyr Thr Trp Gly Leu Arg Trp 
    210                 215                 220                 
Tyr Leu Pro Gly Lys Asp Arg Gly Ile Val Leu Lys Ile Lys Leu Lys 
225                 230                 235                 240 
Ile Asp Thr Ile Thr Gln Thr Val Gly Pro Asn Leu Val Leu Ala Asp 
                245                 250                 255     
Gln Lys Ala Pro Val Gln Leu Ala Ile Pro Val Gln Pro Pro Arg Ala 
            260                 265                 270         
Pro Thr Gln Thr Pro Gly Ile Asn Pro Val Asn Ser Thr Leu Ser Pro 
        275                 280                 285             
Ser Leu Gly Tyr Pro Thr Pro Pro Leu Asp Arg Ala Gln Gly Asp Arg 
    290                 295                 300                 
Leu Leu Asn Leu Val Gln Gly Val Tyr Leu Thr Leu Asn Leu Thr Ala 
305                 310                 315                 320 
Pro Asn Gln Thr Gln Asp Cys Trp Leu Cys Leu 
                325                 330     

<210> 36
<211> 2775
<212> DNA
<213> Artificial Sequence


<220> 
<223> RD114.RBD

<400> 36
cttcttaccc cgcccaaccg tttcgggctc accccgtatg aaatccttta tgggggaccc      60

ccccctttgt caaccttgct caattccttc tccccctccg atcctaagac tgatttacaa     120

gcccgactaa aagggctgca agcggtgcag gcccaaatct ggacacccct ggccgaactg     180

taccggccag gacatccaca aactagccac ccatttcagg taggagactc cgtgtacgtc     240

cagcggcacc gctctcaagg attggagcct cgttggaagg gaccttacat cgtcctgctg     300

accacgccca ccgccataaa ggttgacggg atcgccgcct ggattcacgc atcgcacgcc     360

aaggcagccc caagaacccc tggaccgaaa gctcccaaaa cctggaagct ccaccgttcg     420

gagaaccctc ttaagataag actctcccgt gtctgactgt taatccaccc tgtccctgca     480

caaacccaaa atgaaacccc cagcgggaat ggtctttctg tgggtcctca caagcttggg     540

ggcgggaatt ggagctaaaa ttgtcaaaga ggggaaccca catcaggttt ataccttgac     600

ttggcaaatc tactcccaga gcggggaagt tgtctgggag gtccaaggta accatgcgct     660

taatacttgg tggcccccac ttacccctga tttttgccag ctggcagctg gattagacac     720

ttgggatatc ccagctagaa gccccaagaa cctgcagtcc tacatggggg aaagaatcca     780

gcagatgact gcccatggat gcagtagtcc cactgccaga tgtagattag cccaggcaga     840

gttctatgtc tgtcctcgag acaataggga tagggccact gcccaccgat gtgggggata     900

tgaagaatat ttctgctcgg catggggctg cgaaactact ggcgatgcct actggcaacc     960

tacctcttcc tgggacttaa tcaccattac aagaggttac accaaacctg accccgatgg    1020

acacacttgc tactataaaa agggcacaga agggtatcat cattggataa gtcccctgtc    1080

tctacctctt aagattacct ttacagattc aggaaaacgg gctctcggat ggcagacggg    1140

ctatacatgg ggactccgat ggtacctacc gggaaaagat agggggattg ttctaaaaat    1200

caaattaaaa atagatacaa tcacccaaac cgtaggtccc aacctagtat tggccgatca    1260

aaaagctccg gtccagctag ccatcccagt ccagccacca agggccccaa ctcagacacc    1320

gggaattaac cctgttaatt ccactctaag ccccagtcta ggatacccga ccccccctct    1380

cgaccgggca caaggagata ggctcctaaa ccttgtacaa ggggtatact taactctcaa    1440

ccttacggcc ccaaatcaaa ctcaggactg ttggctctgc ctaacggcta aaccccctta    1500

ctatcaggga gttgctataa ttgggaactt tactaaccat acgaatgccc cactgagatg    1560

tagcactaca cctcgacatg gcctcacttt aactgaagtc accggtcatg gcctatgtat    1620

tgggaaaatt ccaccctcac accagaatct ctgtagtcag accataccat ctgtcgggca    1680

gggtccctat tatttgaccg ctcccaacgg aacgtactgg gtctgtaaca ccggactcac    1740

gccatgcatc tcgctccagg tactcaataa tactgccgac tattgcatcc taattgaact    1800

ttggccaaaa atcttctacc atgactcaga atatatttat ggccactacg aacccggcgg    1860

cagattccgg agagaaccag tttccctcac cgtagcactg ctcctagggg gattaactat    1920

gggaagttta gcagctggca tagggacagg caccgcagct ctcatagaaa ctaatcagtt    1980

caagcagtta caaatcgcta tgcattctga catacaggca ctagaagaat ccatctcggc    2040

actagaaaga tccctaacct ccctctcaga agtggtttta caaaatcgga ggggacttga    2100

cctgttgttc ttacaagaag gcgggttatg tgctgccctc aaagaagagt gctgcttcta    2160

tgctgatcac acaggaatag tgagagacag catggccaag ctgagggaga gactcaaaca    2220

aagacaaaag ctgttcgaat ctcagcaagg ctggtttgag gggtggtata acaaatcccc    2280

ctggtttacc actctagtct cctccctcat gggcccttta atactcctac tattaatact    2340

gatgttcgga ccttgcatcc tcaaccgctt ggtacaattc ataagagaaa gactctctgt    2400

catccaggcc ttggtcctaa ctcaacagta ccaccaacta agacaatttg acgcagaaag    2460

gccagataca atcgaatgaa aggtttcatt cgacgccaaa agaaaatggg ggaatgaaag    2520

acccctgctt agcttaataa cacaccccca ccctatcttc agttccgtaa cgcctcactt    2580

gcagggcttg cacttccacc agttgacaaa caggatatct gcagttagac atccgtaccc    2640

tgggagagct gtacccccac ctttccctac gcaagacagg aacaggttgt cacataaata    2700

acgatgaccg ctttcatctc gcttctgtaa acctgcttac gctcccaaac cggaggtccc    2760

ctgccgcttc gcacc                                                     2775


<210> 37
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> RD114.RBD

<400> 37
Met Lys Leu Pro Thr Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      
Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          
Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              
Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  
Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Ile Ser 
65                  70                  75                  80  
Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln Asp 
                85                  90                  95      
Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Arg Ile 
            100                 105                 110         
Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly Ser 
        115                 120                 125             
Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln Ser 
    130                 135                 140                 
Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr Ala 
145                 150                 155                 160 
Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg Val 
                165                 170                 175     
Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met Thr Pro 
            180                 185                 190         
Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp Leu 
        195                 200                 205             
Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe 
    210                 215                 220         

<210> 38
<211> 181
<212> PRT
<213> Artificial Sequence


<220> 
<223> HERV-W.RBD

<400> 38
Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Leu Leu Pro Ser 
1               5                   10                  15      
Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          
Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              
Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  
His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  
His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      
Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         
Gly Met Ser Asp Gly Gly Gly Val Gln Asp Gln Ala Arg Glu Lys His 
        115                 120                 125             
Val Lys Glu Val Ile Ser Gln Leu Thr Arg Val His Gly Thr Ser Ser 
    130                 135                 140                 
Pro Tyr Lys Gly Leu Asp Leu Ser Lys Leu His Glu Thr Leu Arg Thr 
145                 150                 155                 160 
His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr Leu Thr Gly Leu His 
                165                 170                 175     
Glu Val Ser Ala Gln 
            180     

<210> 39
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> BaEV.RBD

<400> 39
Met Gly Phe Thr Thr Lys Ile Ile Phe Leu Tyr Asn Leu Val Leu Val 
1               5                   10                  15      
Tyr Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Glu Leu Val Gln Lys 
            20                  25                  30          
Arg Tyr Gly Arg Pro Cys Asp Cys Ser Gly Gly Gln Val Ser Glu Pro 
        35                  40                  45              
Pro Ser Asp Arg Val Ser Gln Val Thr Cys Ser Gly Lys Thr Ala Tyr 
    50                  55                  60                  
Leu Met Pro Asp Gln Arg Trp Lys Cys Lys Ser Ile Pro Lys Asp Thr 
65                  70                  75                  80  
Ser Pro Ser Gly Pro Leu Gln Glu Cys Pro Cys Asn Ser Tyr Gln Ser 
                85                  90                  95      
Ser Val His Ser Ser Cys Tyr Thr Ser Tyr Gln Gln Cys Arg Ser Gly 
            100                 105                 110         
Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Thr Gln Thr Gly Gly 
        115                 120                 125             
Thr Ser Asp Val Gln Val Leu Gly Ser Thr Asn Lys Leu Ile Gln Ser 
    130                 135                 140                 
Pro Cys Asn Gly Ile Lys Gly Gln Ser Ile Cys Trp Ser Thr Thr Ala 
145                 150                 155                 160 
Pro Ile His Val Ser Asp Gly Gly Gly Pro Leu Asp Thr Thr Arg Ile 
                165                 170                 175     
Lys Ser Val Gln Arg Lys Leu Glu Glu Ile His Lys Ala Leu Tyr Pro 
            180                 185                 190         
Glu Leu Gln Tyr His Pro Leu Ala Ile Pro Lys Val Arg Asp Asn Leu 
        195                 200                 205             
Met Val Asp Ala Gln Thr Leu Asn Ile Leu Asn Ala Thr Tyr Asn Leu 
    210                 215                 220                 
Leu Leu Met Ser Asn Thr Ser Leu Val Asp Asp Cys Trp Leu Cys 
225                 230                 235                 

<210> 40
<211> 251
<212> PRT
<213> Artificial Sequence


<220> 
<223> SRV.RBD

<400> 40
Met Asn Phe Asn His His Phe Thr Trp Ser Leu Val Ile Ile Ser Gln 
1               5                   10                  15      
Ile Phe Gln Val Gln Ala Gly Phe Gly Asp Pro Arg Glu Ala Leu Leu 
            20                  25                  30          
Glu Ile Gln Gln Lys His Gly Lys Pro Cys Asp Cys Ala Gly Gly Tyr 
        35                  40                  45              
Val Ser Ser Pro Pro Thr Asn Ser Leu Thr Thr Val Ser Cys Ser Thr 
    50                  55                  60                  
Tyr Thr Ala Tyr Ser Val Thr Asn Ser Leu Lys Trp Gln Cys Val Ser 
65                  70                  75                  80  
Thr Pro Thr Thr Ala Ser Pro Thr His Ile Gly Ser Cys Pro Ser Gln 
                85                  90                  95      
Cys Asn Ser Gln Ser Tyr Asp Ser Val His Ala Thr Cys Tyr Asn His 
            100                 105                 110         
Tyr Gln Gln Cys Thr Ile Gly Asn Lys Thr Tyr Leu Thr Ala Thr Met 
        115                 120                 125             
Ile Arg Asp Lys Ser Pro Ser Ser Gly Asp Gly Asn Val Pro Thr Ile 
    130                 135                 140                 
Leu Gly Asn Asn Gln Asn Leu Ile Ile Ala Gly Cys Pro Glu Asn Lys 
145                 150                 155                 160 
Lys Gly Gln Val Val Cys Trp Asn Ser Gln Pro Ser Val His Met Ser 
                165                 170                 175     
Asp Gly Gly Gly Pro Gln Asp Lys Val Arg Glu Ile Ile Val Asn Lys 
            180                 185                 190         
Lys Phe Glu Glu Leu His Lys Ser Leu Phe Pro Glu Leu Ser Tyr His 
        195                 200                 205             
Pro Leu Ala Leu Pro Glu Ala Arg Gly Lys Glu Lys Ile Asp Ala His 
    210                 215                 220                 
Thr Phe Asp Leu Leu Ala Thr Val His Ser Leu Leu Asn Val Ser Ser 
225                 230                 235                 240 
Gln Arg Gln Leu Ala Glu Asp Cys Trp Leu Cys 
                245                 250     

<210> 41
<211> 8173
<212> DNA
<213> Artificial Sequence


<220> 
<223> SRV.RBD

<400> 41
cctgtccgga gccgtgctgc ccggatgatg tcttggcctc tgtttgctct agctctacgc       60

ttaagattca agatggcgaa cttcctggtt cttctctgtg ttgctttccc gccggcgcga      120

atgtttcccg ctcttaggct tacgtggctt tcccagttct gcagttgagc atgcgcccag      180

tacttctccc ctcccactta ctgcctgtgt atataagaca acgcattgcc accattaaac      240

gagacttgat cagaacactg tcttgtctcc atttcttgtg tctcttgtcc catccaattc      300

ccactccctc ctccaggttt cctactgttg gtcccgcggg acgggacatt tggcgcccaa      360

cgtggcgttg gatacgaggg aatttcgtga ggaagacgac gcggtttgcc ggcccggatt      420

aaaagagaaa cgaaagtaaa ctttcttcgg ccgccgcggg agcctgccgc gtaggacctg      480

aaagtaagtg gtgcgctcgg atatggggca ggaattaagc cagcacgaac gttatgtgga      540

acaattaaaa caggctttaa agacacgggg agtaaaggtt aaatatgctg atctcttaaa      600

gttttttgat tttgtaaagg atacttgtcc ttggtttccg caagagggaa ccatagatat      660

caaaaggtgg cgtagagtag gcgattgttt ccaagattat tataatactt ttggccctga      720

gaaagtccca gtaactgcct tctcatactg gaatttaatt aaagaattga tagataagaa      780

agaagttaac ccacaagtaa tggctgccgt ggctcaaact gaagaaatct taaaaactag      840

ttctcataca gagcttacaa caaagccctc ccaaaatcca gacttggacc ttatttctct      900

tgatagtgac gatgaaggag ctaaaggttc ctccctaaaa gataaaaatt tatcatgtac      960

taaaaagcca aaaagattcc cagttctatt aacagcacaa actagtgcgg accctgagga     1020

ccccaacccc tcagaggtag actgggacgg attagaggat gaggcagcaa aatatcataa     1080

tcccgattgg cctcccttcc taacccgtcc acctccttat aataaagcca ctccttccgc     1140

acccactgta atggcggttg ttaatccaaa agaggaatta aaagagaaga ttgctcaatt     1200

agaggaacag attaaattag aagagttaca tcaagcactc atttccaagt tacaaaaact     1260

aaaaacagga aatgaaactg tcactagtcc agaaactgca gggggctttt ctcgcacacc     1320

tcactggccg gggcaacata tccctaaagg aaaatgctgc gccagtcgag aaaaggaaga     1380

acaaacccca aaagatattt tcccagtaac tgaaactgtc gatgggcagg gtcaagcctg     1440

gaggcaccat aatggttttg attttaccgt cataaaagaa ttaaaaacgg ctgcctctca     1500

atatggggct actgccccat acacattagc catagtagaa tctgtagcgg acaattggct     1560

tacccctaca gattggaata cacttgttag ggcagtcctc tcaggaggag atcatttact     1620

atggaaatct gagttttttg aaaattgtag agaaacggct aaaagaaatc aacaagccgg     1680

taatggttgg gattttgata tgttaacagg ctcaggtaac tattctagca ctgatgcaca     1740

aatgcaatat gatccgggat tgtttgctca aattcaagcg gctgctacaa aagcctggag     1800

aaaacttccc gttaagggag acccaggagc ttcccttaca ggagtcaaac aaggacccga     1860

tgagccattt gcagattttg tacacagact tataacaact gctgggagaa tttttggaag     1920

tgctgaggct ggtgtagact atgtaaaaca actagcatat gaaaacgcta atccagcctg     1980

tcaggcagcc atccgcccct atagaaagaa aacagattta actggctaca tccgcctttg     2040

ttcggacatt gggccttctt atcaacaggg cttagccatg gccgccgcct ttagcggaca     2100

aactgtcaaa gattttctta acaacaaaaa taaagaaaaa ggagggtgtt gttttaaatg     2160

cgggaggaaa ggacattttg caaaaaattg tcatgaacat atacataaca attctgaaac     2220

aaaggctcct ggactctgtc ccaggtgtaa aagagggaaa cattgggcca atgaatgcaa     2280

atccaaaact gatagtcaag gaaacccact accaccccat cagggaaacg gactgagggg     2340

ccagccccag gccccgaaac aagcttatgg ggcggtcagc tttgttccag ccaacaaaaa     2400

caacccattt caaagcttac cagagccacc ccaggaagtg caggattgga cctcagttcc     2460

acctcccaca cagtattaac accggaaatg gggccccaag cgttaagcac tggaatatat     2520

gggcccctac ctcccaacac ttttggatta atcttaggca gaagtagcat tactataaaa     2580

ggtctacaag tttatccagg agtaattgat aatgactata ctggggaaat taaaataatg     2640

gcaaaggctg tcaacaatat tgttactgtt cctcaaggca acaggatagc tcaattaatc     2700

ctcctacctc taattgagac agacaataaa gtacaacaac cctatagagg acaaggaagt     2760

tttggatcct cagacatata ttgggtccaa cctattacct gtcagaagcc ctccttaaca     2820

ttatggttag atgataaaat gttcacagga ttaatcgata cgggagctga tgtcactatc     2880

atcaagctag aggactggcc tcctaattgg cctataacag ataccttaac caatttaaga     2940

ggtataggac aaagcaacaa ccctaagcaa agttctaaat atcttacttg gagagataaa     3000

gaaaataatt ctggtctcat taaaccgttt gttattccta atttacctgt caacctttgg     3060

ggcagagatc tcctttctca aatgaaaatt atgatgtgta gtcctagtga catagtcact     3120

gcccaaatgt tagcccaagg ctacagcccc ggaaaaggat taggaaaaaa cgaaaatggc     3180

attctacatc ctatcccaaa tcaaggacaa tttgacaaaa agggatttgg aaatttttaa     3240

ctgcggccat tgacatgctt gcaccccaac agtgtgctga acccatcacg tggaaatcag     3300

acgaacctgt ctgggttgat cagtggccat taaccagtga aaaacttgct gctgcccaac     3360

agttagtgca agaacagtta gaggcaggac atattactga aagtaattcc ccttggaaca     3420

ctcccatatt tgttataaaa aagaaatctg gtaaatggag gctcttacaa gatttacgag     3480

ccgttaatgc cactatggta ttaatgggag ctttacaacc tggattgccc tctccggtgg     3540

ctatcccaca agggtatctt aaaataatta ttgatctcaa agattgtttc ttttctattc     3600

cccttcatcc tagtgatcaa aaaaggtttg cattcagcct accttccaca aattttaagg     3660

aacctatgca acgttttcag tggaaagttt taccgcaacg tatggccaac agccctacct     3720

tatgccaaaa atatgtggcc acagccatac ataaagttag acatgcctgg aaacaaatgt     3780

atattataca ttacatggat gatatcctca tagctggtaa agatggacaa caagttttac     3840

aatgctttga tcagctcaaa caagaattga ctatagccgg gttacatata gccccagaaa     3900

aaattcaact acaagacccc tacacgtatt taggatttga acttaatggt ccaaaaatca     3960

ctaatcaaaa ggcagttatt cgtaaagata agttgcaaac tcttaatgac tttcaaaagc     4020

ttttaggaga catcaattgg ctccgaccat acctgaaact cactactgca gatttaaaac     4080

ctttattcga cacccttaaa ggagactcta atcccaattc tcatagatct ttatcaaaag     4140

aagctcttgc cttacttgat aaagtagaaa cagccattgc agaacaattt gttactcaca     4200

taaattattc attaccatta atgtttctca tatttaacac agccctgacg cccactggtt     4260

tattttggca gaataatcct attatgtggg tccacctgcc tgcatcccct aaaaaggtat     4320

tactccccta ttacgacgct atagcagatt taatcatact aggaagagac catagtaaaa     4380

aatactttgg aattgaaccc tccgtaatca tacagccata ctctaagtct caaattgatt     4440

ggctgatgca aaacactgaa atgtggccaa ttgcctgtgc ctcttatgtt ggcatcctag     4500

ataaccatta cccacctaac aagcttatcc aattctgcaa attacatgcc tttattttcc     4560

ctcaaatcat tagtaaaacg cccttaaaca atgctttatt agtttttact gatggctctt     4620

ccactggaat ggccgcatat actcttgctg atactaccat caaatttcaa actaatctta     4680

attcggctca actagtagaa ttacaagcct taattgcagt cctatcagct ttccccaacc     4740

aacctcttaa catttatact gacagtgctt acttagccca ctcaataccc ctgcttgaaa     4800

ctgtagcaca aattaaacac atatcagaaa cagcaaagct attcctacag tgccaacagc     4860

ttatatacaa tagatccata cctttttaca tcggacatgt cagggcccat tctggcctac     4920

ctggacctat agcccacggc aaccaaaagg ctgacttggc aactaaaacc gtggctagca     4980

acataaacac aaacctcgaa tcggctcaaa atgctcatac cttacatcat ctcaatgccc     5040

aaactttaaa actaatgttt aacattccga gagaacaagc tagacaaatt gtcagacaat     5100

gcccaatatg tgcaacctat ctaccagtcc ctcatttagg agttaatcct agaggattgt     5160

tgcccaacat gatttggcaa atggacgtta cacattactc cgaatttggt aatttaaaat     5220

atatacatgt ttctatagat accttcagtg gattcctatt agccactcta cagacaggag     5280

aaacaacaaa acatgtcata acccatttac ttcattgctt ctctattatt ggactcccta     5340

aacaaataaa aacagataac ggtcctggat acacctccaa aaattttcaa gaattctgct     5400

ccacacttca aattaaacat gttactggaa tcccctataa tccccaaggc caaggaatag     5460

ttgaaagagc ccacttatct cttaaaacca ccattgaaaa aataaaaaag ggggaatggt     5520

accctacgaa gggtaccccc aggaacattc tcaatcatgc actctttatt ctaaattttt     5580

taaatttgga tgatcaaaac cactcagcag ctgatcgttt ttggcatagc aaccccagaa     5640

aacaatttgc catggtaaaa tggaaagatc cactagacaa tacgtggcca tggcctgatc     5700

cagtgataat ttggggcaga ggttcagtct gtgtttactc tcaaacccat gatgccgcta     5760

gatggctacc agaacgacta gtaaaacaaa tacctaacaa taaccaatcc agggagtgat     5820

tctctccctg agattgcctt ttcctttgct cacagagatg aacttcaatc atcatttcac     5880

ctggagctta gtgataatat ctcaaatatt ccaagttcaa gccggttttg gagatccgcg     5940

cgaggccctc ctagagatac aacaaaaaca tggtaagcct tgtgactgtg ctggaggata     6000

tgtttccagt ccacctacta attcccttac aactgtctca tgctctactt atactgctta     6060

ttcagtaacc aactccctaa agtggcagtg tgtgtctact cccactacag ccagccccac     6120

acatatagga tcttgtccca gtcaatgtaa ctcacaatca tatgactctg tacatgccac     6180

ctgctataac cactatcaac aatgtactat tggtaataag acatatctca ctgctactat     6240

gattagagac aaatctccct ccagtggtga cgggaacgtc cctacaatat tagggaataa     6300

tcaaaacctc attatagcag gctgtcccga aaataaaaag ggccaagtgg tttgctggaa     6360

tagccaaccc tctgttcaca tgtctgatgg aggagggcct caagataagg tccgtgagat     6420

tatagtaaat aaaaagtttg aagaattgca taaatcgctg ttcccagaac tttcttacca     6480

ccctctggct ttgcccgaag cccgtggtaa agaaaaaatt gatgcacaca cttttgatct     6540

ccttgccact gtgcatagtt tactcaatgt ttcctcccaa cgccaattag ccgaagattg     6600

ctggctgtgc ttgcggtcag gtgatcccgt tcctctcgcc ctgccttatg ataacacatc     6660

ctgctctaac tcaacctttt tctttaattg ctctaattgc tcttgcctta tcaccccccc     6720

tttcttagta cagcccttta acttcactca ttctgtttgc ctttacgctg attatcaaaa     6780

caactcattt gacatagatg taggtctagc tggcttcact aattgctcta gttatattaa     6840

tatttctaaa ccctccagtc ccttatgcgc cccaaatagc tcagtttttg tatgcggtaa     6900

taacaaggca tacacttatc tacccacaaa ttggacggga agctgtgtac ttgctactct     6960

tttacccgat atagacatta ttccaggtag tgaacctgtc cccattccag ctatagatca     7020

ttttttaggt agacccaaaa gagcaatcca gtttattccc ctagtcatag gattaggtat     7080

aactactgca gtatctaccg ggactgctgg tctgggggtt tccctcactc aatacacaaa     7140

attgtctcac caactaatat cagatgtaca agctatttct agtactatac aagatctcca     7200

agatcaagta gactctctag cagaagtagt actacaaaac agaagaggat tagatctgct     7260

gacagcagag cagggaggca tctgcttagc tttacaggaa aaatgctgtt tctacgccaa     7320

caaatctgga atcgtcagag acaagattaa aaacctacaa gatgacttag aaaaacgccg     7380

aaaacaactg atcgacaacc ccttttggac tggctttcat ggactcctcc cttatgttat     7440

gcctctatta ggccctttac tttgcttact gcttgtgtta tctttcggac caattatctt     7500

caataagctt atgactttta ttaaacatca aatcgagagc attcaagcca aacctataca     7560

ggtccattat catcgccttg aacaagaaga ccatggtggc tcatatttaa acttaacata     7620

gaccacctcc cctgcgagct aagctggaca gccaatgacg ggtaagagag tgacattttt     7680

cactaaccta agacaggagg gccgtcagag ctactgccta atccaaagac gggtaaaagt     7740

gataaaaatg tatcactcca acctaagaca ggcgcagctt ccgagggatt tgtcgtctgt     7800

tttatatata tttaaaaggg tgacctgtcc ggagccgtgc tgcccggatg atgtcttggc     7860

ctctgtttgc tctagctcta cgcttaagat tcaagatggc gaacttcctg gttcttctct     7920

gtgttgcttt cccgccggcg cgaatgtttc ccgctcttag gcttacgtgg ctttcccagt     7980

tctgcagttg agcatgcgcc cagtacttct cccctcccac ttactgcctg tgtatataag     8040

acaacgcatt gccaccatta aacgagactt gatcagaaca ctgtcttgtc tccatttctt     8100

gtgtctcttg tcccatccaa ttcccactcc ctcctccagg tttcctactg ttggtcccgc     8160

gggacgggac att                                                        8173


<210> 42
<211> 258
<212> PRT
<213> Artificial Sequence


<220> 
<223> SNV.RBD

<400> 42
Met Asp Cys Leu Thr Asn Leu Arg Ser Ala Glu Gly Lys Val Asp Gln 
1               5                   10                  15      
Ala Ser Lys Ile Leu Ile Leu Leu Val Ala Trp Trp Gly Phe Gly Thr 
            20                  25                  30          
Thr Ala Glu Gly Tyr Pro Leu Gln Gln Leu Trp Glu Leu Pro Cys Asp 
        35                  40                  45              
Cys Ser Gly Gly Tyr Val Ser Ser Ile Pro Thr Tyr Tyr Thr Tyr Ser 
    50                  55                  60                  
Leu Asp Cys Gly Gly Ser Thr Ala Tyr Leu Thr Tyr Gly Ser Gly Thr 
65                  70                  75                  80  
Gly Ser Trp Ser Trp Gly Gly Gly Phe Lys Gln Gln Trp Glu Cys Val 
                85                  90                  95      
Phe Lys Pro Lys Ile Ile Pro Ser Val Gln Gly Gln Pro Gly Pro Cys 
            100                 105                 110         
Pro Ser Glu Cys Leu Gln Ile Ala Thr Gln Met His Ser Thr Cys Tyr 
        115                 120                 125             
Glu Lys Thr Gln Glu Cys Thr Leu Leu Gly Lys Thr Tyr Phe Thr Ala 
    130                 135                 140                 
Ile Leu Gln Lys Thr Lys Leu Gly Ser Tyr Glu Asp Gly Pro Asn Lys 
145                 150                 155                 160 
Leu Ile Gln Ala Ser Cys Thr Gly Thr Val Gly Lys Pro Val Cys Trp 
                165                 170                 175     
Asp Pro Val Ala Pro Val Tyr Val Ser Asp Gly Gly Gly Pro Thr Asp 
            180                 185                 190         
Met Ile Arg Glu Glu Ser Val Arg Glu Arg Leu Glu Glu Ile Ile Arg 
        195                 200                 205             
His Ser Tyr Pro Ser Val Gln Tyr His Pro Leu Ala Leu Pro Arg Ser 
    210                 215                 220                 
Arg Gly Val Asp Leu Asp Pro Gln Thr Ser Asp Ile Leu Glu Ala Thr 
225                 230                 235                 240 
His Gln Val Leu Asn Ala Thr Asn Pro Gln Leu Ala Glu Asn Cys Trp 
                245                 250                 255     
Leu Cys 
        

<210> 43
<211> 567
<212> PRT
<213> Artificial Sequence


<220> 
<223> SNV.RBD

<400> 43
Met Asp Cys Leu Thr Asn Leu Arg Ser Ala Glu Gly Lys Val Asp Gln 
1               5                   10                  15      
Ala Ser Lys Ile Leu Ile Leu Leu Val Ala Trp Trp Gly Phe Gly Thr 
            20                  25                  30          
Thr Ala Glu Gly Tyr Pro Leu Gln Gln Leu Trp Glu Leu Pro Cys Asp 
        35                  40                  45              
Cys Ser Gly Gly Tyr Val Ser Ser Ile Pro Thr Tyr Tyr Thr Tyr Ser 
    50                  55                  60                  
Leu Asp Cys Gly Gly Ser Thr Ala Tyr Leu Thr Tyr Gly Ser Gly Thr 
65                  70                  75                  80  
Gly Ser Trp Ser Trp Gly Gly Gly Phe Lys Gln Gln Trp Glu Cys Val 
                85                  90                  95      
Phe Lys Pro Lys Ile Ile Pro Ser Val Gln Gly Gln Pro Gly Pro Cys 
            100                 105                 110         
Pro Ser Glu Cys Leu Gln Ile Ala Thr Gln Met His Ser Thr Cys Tyr 
        115                 120                 125             
Glu Lys Thr Gln Glu Cys Thr Leu Leu Gly Lys Thr Tyr Phe Thr Ala 
    130                 135                 140                 
Ile Leu Gln Lys Thr Lys Leu Gly Ser Tyr Glu Asp Gly Pro Asn Lys 
145                 150                 155                 160 
Leu Ile Gln Ala Ser Cys Thr Gly Thr Val Gly Lys Pro Val Cys Trp 
                165                 170                 175     
Asp Pro Val Ala Pro Val Tyr Val Ser Asp Gly Gly Gly Pro Thr Asp 
            180                 185                 190         
Met Ile Arg Glu Glu Ser Val Arg Glu Arg Leu Glu Glu Ile Ile Arg 
        195                 200                 205             
His Ser Tyr Pro Ser Val Gln Tyr His Pro Leu Ala Leu Pro Arg Ser 
    210                 215                 220                 
Arg Gly Val Asp Leu Asp Pro Gln Thr Ser Asp Ile Leu Glu Ala Thr 
225                 230                 235                 240 
His Gln Val Leu Asn Ala Thr Asn Pro Lys Leu Ala Glu Asn Cys Trp 
                245                 250                 255     
Leu Cys Met Thr Leu Gly Thr Pro Ile Pro Ala Ala Ile Pro Thr Asn 
            260                 265                 270         
Gly Asn Val Thr Leu Asp Gly Asn Cys Ser Leu Ser Leu Pro Phe Gly 
        275                 280                 285             
Cys Asn Pro Pro Gly Ser Ile Asp Val Ser Cys Tyr Ala Gly Glu Ala 
    290                 295                 300                 
Asp Asn Arg Thr Gly Ile Pro Val Gly Tyr Val His Phe Thr Asn Cys 
305                 310                 315                 320 
Thr Ser Ile Gln Glu Val Thr Asn Glu Thr Ser Gln Met Gly Asn Leu 
                325                 330                 335     
Thr Arg Leu Cys Pro Pro Pro Gly His Val Phe Val Cys Gly Asn Asn 
            340                 345                 350         
Met Ala Tyr Thr Ala Leu Pro Asn Lys Trp Ile Gly Leu Cys Ile Leu 
        355                 360                 365             
Ala Ser Ile Val Pro Asp Ile Ser Ile Ile Ser Gly Glu Glu Pro Ile 
    370                 375                 380                 
Pro Leu Pro Ser Ile Glu Tyr Thr Ala Arg Arg His Lys Arg Ala Val 
385                 390                 395                 400 
Gln Phe Ile Pro Leu Leu Val Gly Leu Gly Ile Ser Gly Ala Thr Leu 
                405                 410                 415     
Ala Gly Gly Thr Gly Leu Gly Val Ser Val His Thr Tyr His Lys Leu 
            420                 425                 430         
Ser Asn Gln Leu Ile Glu Asp Val Gln Ala Leu Ser Gly Thr Ile Asn 
        435                 440                 445             
Asp Leu Gln Asp Gln Ile Asp Ser Leu Ala Glu Val Val Leu Gln Asn 
    450                 455                 460                 
Arg Arg Gly Leu Asp Leu Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu 
465                 470                 475                 480 
Ala Leu Gln Glu Lys Cys Cys Phe Tyr Ala Asn Lys Ser Gly Ile Val 
                485                 490                 495     
Arg Asp Lys Ile Arg Lys Leu Gln Glu Asp Leu Ile Glu Arg Lys Arg 
            500                 505                 510         
Ala Leu Tyr Asp Asn Pro Leu Trp Ser Gly Leu Asn Gly Phe Leu Pro 
        515                 520                 525             
Tyr Leu Leu Pro Leu Leu Gly Pro Leu Phe Gly Leu Ile Leu Phe Leu 
    530                 535                 540                 
Thr Leu Gly Pro Cys Ile Met Lys Thr Leu Thr Arg Ile Ile His Asp 
545                 550                 555                 560 
Lys Ile Gln Ala Val Lys Ser 
                565         

<210> 44
<211> 250
<212> PRT
<213> Artificial Sequence


<220> 
<223> MPMV.RBD

<400> 44
Met Asn Phe Asn Tyr His Phe Ile Trp Ser Leu Val Ile Leu Ser Gln 
1               5                   10                  15      
Ile Ser Gln Val Gln Ala Gly Phe Gly Asp Pro Arg Glu Ala Leu Ala 
            20                  25                  30          
Glu Ile Gln Gln Lys His Gly Lys Pro Cys Asp Cys Ala Gly Gly Tyr 
        35                  40                  45              
Val Ser Ser Pro Pro Ile Asn Ser Leu Thr Thr Val Ser Cys Ser Thr 
    50                  55                  60                  
His Thr Ala Tyr Ser Val Thr Asn Ser Leu Lys Trp Gln Cys Val Ser 
65                  70                  75                  80  
Thr Pro Thr Thr Pro Ser Asn Thr His Ile Gly Ser Cys Pro Gly Glu 
                85                  90                  95      
Cys Asn Thr Ile Ser Tyr Asp Ser Val His Ala Ser Cys Tyr Asn His 
            100                 105                 110         
Tyr Gln Gln Cys Asn Ile Gly Asn Lys Thr Tyr Leu Thr Ala Thr Ile 
        115                 120                 125             
Thr Gly Asp Arg Thr Pro Ala Ile Gly Asp Gly Asn Val Pro Thr Val 
    130                 135                 140                 
Leu Gly Thr Ser His Asn Leu Ile Thr Ala Gly Cys Pro Asn Gly Lys 
145                 150                 155                 160 
Lys Gly Gln Val Val Cys Trp Asn Ser Arg Pro Ser Val His Ile Ser 
                165                 170                 175     
Asp Gly Gly Gly Pro Gln Asp Lys Ala Arg Asp Ile Ile Val Asn Lys 
            180                 185                 190         
Lys Phe Glu Glu Leu His Arg Ser Leu Phe Pro Glu Leu Ser Tyr His 
        195                 200                 205             
Pro Leu Ala Leu Pro Glu Ala Arg Gly Lys Glu Lys Ile Asp Ala His 
    210                 215                 220                 
Thr Leu Asp Leu Leu Ala Thr Val His Ser Leu Leu Asn Ala Ser Gln 
225                 230                 235                 240 
Pro Ser Leu Ala Glu Asp Cys Trp Leu Cys 
                245                 250 

<210> 45
<211> 8557
<212> DNA
<213> Artificial Sequence


<220> 
<223> MPMV.RBD

<400> 45
gccaccatta aatgagactt gatcagaaca ctgtcttgtc tccatttctt gtgtctcttg       60

ttcccttcaa ttcccactcc ctcctccagg ttcctactgt tgatcccgcg ggtcgggaca      120

gttggcgccc aacgtggggc tggatacgag ggaatttcgt gaggaagacg acgcgttcgc      180

cggccggcga ttaaaagtga aagtaaactc tcttggccgc cgcgggaacc tgccgcgttg      240

gacctgaaag taagtgttgc gctcggatat ggggcaagaa ttaagccagc atgaacgtta      300

tgtagaacaa ttgaagcagg ctttaaagac acggggagta aaggttaaat atgctgatct      360

tttgaaattt tttgattttg tgaaggatac ttgtccttgg tttccgcaag agggaaccat      420

agatattaaa cggtggcgta gagtaggcga ctgtttccaa gactattaca atacttttgg      480

cccggagaaa gtcccagtaa ctgcattctc ttactggaac ttaattaaag aattgataga      540

taagaaagaa gttaacccac aagtaatggc tgccgtagcc caaactgaag aaattttaaa      600

aagtaattct caaacagacc tcacaaagac ctctcaaaac ccagacttgg accttatttc      660

ccttgatagc gacgatgaag gagctaaaag ttcctctcta caagataaag gtttatcaag      720

tactaaaaaa ccaaaaagat tcccagttct gttaacagca caaactagta aagaccctga      780

agaccccaac ccctcagagg tagactggga cggcttggaa gatgaggcag cgaaatatca      840

taatcccgat tggcctccct tcctaacccg tccacctcct tacaataaag ctactccttc      900

cgcacccact gtaatggcgg ttgttaatcc aaaagaggag ctcaaagaaa aaattgctca      960

attagaggaa cagattaaat tagaagagtt acaccaggca ctaatttcca aattacaaaa     1020

actaaaaaca gggaatgaaa ctgtaactca cccagacaca gcaggaggcc tttctcgcac     1080

gcctcactgg ccagggcaac atatccctaa aggaaaatgt tgcgccagtc gagaaaagga     1140

agaacaaatc ccaaaagata ttttcccagt gactgaaacc gttgatgggc aaggtcaagc     1200

ctggagacac cataatggtt ttgattttgc cgtcataaaa gaattaaaaa cagctgcttc     1260

ccaatatggg gctactgccc catacacatt agccatagtg gaatctgtag cggacaattg     1320

gcttacccct acagattgga atacgcttgt tagggcagtc ctctcaggag gagatcactt     1380

actgtggaaa tctgagtttt ttgaaaattg cagagatacg gctaaaagaa accaacaagc     1440

cggtaatggc tgggattttg acatgttaac aggttcgggt aattattcca gcaccgatgc     1500

acaaatgcag tatgatccag gattgtttgc tcaaattcaa gcggctgcta caaaagcctg     1560

gagaaaactt cccgttaagg gagacccagg agcctccctt acaggagtca aacaaggacc     1620

cgatgagcca tttgcagatt tcgtacacag acttataaca actgctggga gaatctttgg     1680

aagtgctgag gccggtgtag actatgtaaa acaactagca tatgaaaatg ctaatccagc     1740

ttgtcaggca gccattcgcc cctatagaaa gaagacagat ttaactggct atatccgtct     1800

ttgctcggat attgggccct cttatcagca aggcctggcc atggccgccg cctttagcgg     1860

gcagactgta aaagattttc ttaacaacaa aaataaagag aaaggagggt gttgctttaa     1920

atgcggtaaa aaaggacact ttgcaaaaaa ttgtcatgaa catgcacata acaatgctga     1980

accaaaagtt cccggactct gccctagatg taaaagaggg aaacattggg ccaatgaatg     2040

caaatccaaa actgataatc aaggaaaccc aataccaccc catcagggaa acgggtggag     2100

gggccagccc caggccccga aacaagctta tggggcagtc agctttgttc cagccaacaa     2160

aaacaaccca tttcaaagct taccagagcc accccaggaa gtgcaggatt ggacctctgt     2220

tccacctccc acacagtatt aacgcctgaa atggggcccc aagcgttaag cactggaata     2280

tatggaccac tgcctcccaa cacttttgga ttaatcctag gccgaagtag cattactatg     2340

aagggtctac aagtttatcc aggagtaatt gataatgact ataccggaga aattaaaatt     2400

atggcaaaag ctgttaacaa tattgttact gtctctcaag gcaacagaat agctcaatta     2460

atcctcctgc ctctgatcga gacagacaat aaggtacaac aaccttatag aggacaagga     2520

agttttggat cctcagacat atattgggtc caacctatta cttgtcaaaa accttcctta     2580

acattatggt tagatgacaa aatgttcaca ggcttaatag atacgggggc tgatgtcaca     2640

attatcaagc tggaggactg gcctcctaat tggcctataa cagatacctt aaccaattta     2700

agaggaatag gacaaagtaa caaccctaaa caaagttcta aatatcttac ttggagagat     2760

aaagaaaaca attctggtct catcaaaccg tttgttattc ctaacttacc tgtcaatctt     2820

tggggccgag atttactttc tcaaatgaaa attatgatgt gtagccccaa tgacatagta     2880

actgctcaaa tgttagccca gggctacagc ccaggaaaag ggttaggaaa aaaggaaaat     2940

ggcattctac atcctatccc aaatcaagga caatctaaca aaaaaggttt tggaaatttt     3000

taactgcggc cattgacata cttgcacccc aacagtgcgc tgaacccatc acgtggaaat     3060

cagacgaacc tgtctgggtt gatcagtggc cattaaccaa tgacaaactt gctgctgccc     3120

aacagttagt gcaagaacag ttagaggcag gacatattac tgaaagtagt tctccctgga     3180

acactcccat atttgttata aaaaagaaat ctggtaaatg gaggctctta caagatttac     3240

gagccgttaa tgccactatg gtattaatgg gagctttaca acctggatta ccctccccgg     3300

tggctatccc acaagggtat cttaaaataa ttattgatct caaggattgt ttcttttcta     3360

ttccccttca tcctagtgac caaaaaagat ttgccttcag cctaccatcc acaaatttta     3420

aagaacctat gcaacgtttt cagtggaagg ttttaccaca aggtatggcc aacagtccta     3480

ccttatgtca aaaatatgtg gccacagcca tacataaggt tagacatgcc tggaaacaaa     3540

tgtatattat acattacatg gatgacatcc taatagctgg taaagatgga caacaagttt     3600

tgcaatgctt tgatcaactc aaacaagagt tgactgcagc tgggttacat atagccccag     3660

aaaaagttca attacaagat ccctacacat atttaggatt tgaacttaat ggtcctaaaa     3720

tcactaatca aaaagcagtc attcgtaaag ataaattaca gactcttaat gatttccaaa     3780

aacttttagg agacatcaat tggctcagac catatctaaa actcactact ggagacttaa     3840

aacccttatt cgacaccctt aaaggagact ctgaccccaa ttcccataga tccttatcaa     3900

aagaagctct tgcctcactt gaaaaggtag agacagccat tgcagaacaa ttcgttactc     3960

acataaatta ttcactacca ttaattttcc tcatattcaa cacagccctg acacctactg     4020

gtttgttttg gcaagacaat cctattatgt ggatccacct gcctgcatcc cctaaaaagg     4080

tgttacttcc ctactacgac gctatagcag atttaatcat actagggaga gaccatagta     4140

aaaaatattt tggaattgaa ccctctacaa tcatacaacc atattctaag tctcagattg     4200

attggttaat gcaaaacact gaaatgtggc caattgcctg tgcctccttt gttggcatcc     4260

tagataacca ttatccacca aataaactta tccagttctg taaactacat acctttgttt     4320

tccctcaaat cattagtaaa acacccttaa acaatgcctt attagttttt actgatggct     4380

cttccactgg gatggccgca tatactctta ctgataccac catcaaattc caaactaatc     4440

ttaattcggc tcaactagta gaactacaag ctttaattgc agtcttatca gccttcccta     4500

atcaacctct taatatttac actgacagtg cttacttagc ccactcaata cccctacttg     4560

aaactgtcgc acaaattaaa cacatatcag aaacagctaa actgttccta cagtgccagc     4620

aactcatata caatagatcc ataccttttt atattggaca tgtcagggcc cattctggac     4680

tacctggacc catagctcaa ggcaaccaac gagctgactt ggcaactaaa atcgtggcta     4740

gtaacataaa cacaaacctc gaatcagctc aaaatgctca taccttacat cacctcaatg     4800

cccagacttt aagacttatg tttaacattc ctagagaaca agctagacaa attgttaagc     4860

aatgtcctat atgtgtaact tatctaccag tccctcattt aggagttaat cctaggggat     4920

tatttcccaa catgatttgg caaatggatg ttacacacta ctcagaattt ggcaatttaa     4980

aatatattca tgtatctata gatacattca gtggattcct actggccact ctacaaacag     5040

gagaaactac aaaacatgtc ataacccatt tactccattg cttctctatt attggactcc     5100

ctaaacaaat taaaacggat aacggtcctg gatacacctc taaaaatttt caagaatttt     5160

gctccacact tcaaattaaa catattactg gaatccccta taacccccaa ggccaaggaa     5220

tagttgaaag agcccactta tctcttaaaa ccaccattga aaagataaaa aagggggaat     5280

ggtaccctag gaagggtacc cccaggaaca tcctcaatca tgcactcttt attctaaatt     5340

ttttaaattt agatgatcaa aataaatcag cagctgatcg tttttggcat aataacccca     5400

aaaaacaatt tgccatggta aaatggaaag atccattaga taatacatgg catggccccg     5460

atccagtgtt aatttggggc agaggttcag tctgtgttta ctctcaaacc tatgatgccg     5520

ctagatggct accagaacgg ttagtaagac aggtgtctaa caataaccaa tccagggagt     5580

gattctctcc ctgagatcgc tctttccctt gttcacagat atgaacttca attatcattt     5640

catctggagc ttagtgatac tatctcaaat atctcaagtt caagccggtt ttggagatcc     5700

gcgtgaagcc ctggcagaaa tacaacaaaa acatggtaaa ccttgtgact gtgctggagg     5760

atatgtttcc tccccaccga ttaactctct tacaactgtt tcttgctcta ctcatactgc     5820

ttattcagtg acaaactccc taaaatggca gtgtgtgtca actcccacta cccctagcaa     5880

tacacatata ggaagttgtc ccggtgaatg caacacgatc tcatatgatt ctgtacatgc     5940

ctcttgctat aaccactatc aacaatgtaa cattggtaat aaaacatatc tcactgccac     6000

tataactgga gatagaactc ctgccattgg tgacgggaat gtccctacag tactagggac     6060

tagtcacaac ctcattacag caggctgtcc caatggtaaa aagggccaag tggtctgttg     6120

gaatagccga ccttctgttc atatatctga tggaggaggg cctcaagata aggcccgcga     6180

cattatagta aataaaaagt ttgaggaatt gcacaggtcg ctgttcccag aactttctta     6240

ccatcctctg gccttgcccg aagcccgtgg taaagaaaaa attgacgcac acactcttga     6300

tctccttgcc actgtacata gtttactcaa tgcttcccaa cccagtttag ccgaagattg     6360

ctggctgtgc ttacagtcag gagatcccgt tcctcttgcc ctgccctata atgatacact     6420

ctgctctaac tttgcctgtt tatctaatca ctcctgccct ttaacccccc cttttttagt     6480

acagcccttt aacttcactg attccaattg cctttacgct cattatcaaa acaactcatt     6540

tgacatagat gtaggtctag ctagctttac taattgctct agctattata acgtttctac     6600

agcctccaaa ccctctaatt ccctatgcgc cccaaacagc tcggtttttg tatgcggtaa     6660

caataaggca tacacttatc tacccacaaa ttggacggga agttgtgtac ttgctactct     6720

tttgcccgat atagacatca ttccaggtag tgagcctgtc cccattccag ctattgatca     6780

ttttttaggc aaagccaaaa gagcaatcca acttatcccc ctgttcgtag ggttaggtat     6840

aactactgca gtatctactg gggctgctgg tctaggggtt tccatcactc aatatacaaa     6900

attatctcat caactaatat cagatgttca agctatttct agcactatac aagatctcca     6960

agatcaggta gactctctag cagaagtagt actgcaaaac agaagaggat tagatctact     7020

tacagcagag cagggaggta tctgcttagc cttacaggaa aaatgttgtt tctacgccaa     7080

taaatctgga atcgtcagag acaagattaa aaacctacaa gacgacttag aaagacgccg     7140

aagacaactg atcgacaacc cattttggac cagttttcat ggattcctcc cttatgttat     7200

gcccctatta ggccctttgc tttgcttatt gcttgtgtta tctttcggtc caattatttt     7260

caacaagctt atgaccttta ttaaacatca aattgagagc atccaggcca aacctataca     7320

agtccattat catcgccttg aacaagaaga cagtggtggc tcatatttga ccttaacata     7380

ggccacctcc cctgtgagct agactggaca gccaatgacg ggtaagagag tgacatttct     7440

cactaaccta agacaggagg gccgtcaaag ctactgccta atccaatgac gggtaatagt     7500

gacaagaaat gtatcactcc aacctaagac aggcgcagcc tccgagggat gtgtcttttg     7560

ttttttataa ttaaaaaggg tgacatgtcc ggagccgtgc tgcccggatg atgtcttggc     7620

ctctgtttgc tctagctcca tgttatgaat ttaagatggc gtatttcctg gttcttctcc     7680

gtcttacttt cccgccggcg cgaatgtttc ccgctcttgg gcttacgtgg ctttccttgc     7740

tctgctactg agcatgcgcc cagtatcttt cccctcccac ttgctgcctg tgtatataag     7800

gcaacacatt gccaccatta aatgagactt gatcagaaca ctgtcttgtc tccatttctt     7860

gtgtctcttg ttcccttcaa ttcccactcc ctcctccagg ttcctactgt tgatcccgcg     7920

ggtcgggaca gttttcgttt tctgtccgga gccgtgctgc ccggatgatg tcttggcctc     7980

tgtttgctct agctccatgt tatgaattta agatggcgta tttcctggtt cttctccgtc     8040

ttactttccc gccggcgcga atgtttcccg ctcttgggct tacgtggctt tccttgctct     8100

gctactgagc atgcgcccag tatctttccc ctcccacttg ctgcctgtgt atataaggca     8160

acacattgcc accattaaat gagacttgat cagaacactg tcttgtctcc atttcttgtg     8220

tctcttgttc ccttcaattc ccactccctc ctccaggttc ctactgttga tcccgcgggt     8280

cgggacagtt ggcgcccaac gtggggcacg aacccacgac cctgggatta agagtcccat     8340

gctctaccga ctggatgatg tcttggcctc tgtttgctct agctccatgt tatgaattta     8400

agatggcgta tttcctggtt cttctccgtc ttactttccc gccggcgcga atgtttcccg     8460

ctcttgggct tacgtggctt tccttgctct gctactgagc atgcgcccag tatctttccc     8520

ctcccacttg ctgcctgtgt atataaggca acacatt                              8557


<210> 46
<211> 189
<212> PRT
<213> Artificial Sequence


<220> 
<223> HERV-W.RBD

<400> 46
Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Leu Leu Pro Ser 
1               5                   10                  15      
Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          
Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              
Ala Pro Ser Tyr Arg Ser Leu Cys Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  
His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  
His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      
Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         
Gly Met Ser Asp Gly Gly Gly Val Gln Asp Gln Ala Arg Glu Lys His 
        115                 120                 125             
Val Lys Glu Val Ile Ser Gln Leu Thr Arg Val His Gly Thr Ser Ser 
    130                 135                 140                 
Pro Tyr Lys Gly Leu Asp Leu Ser Lys Leu His Glu Thr Leu Arg Thr 
145                 150                 155                 160 
His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr Leu Thr Gly Leu His 
                165                 170                 175     
Glu Val Ser Ala Gln Asn Pro Thr Asn Cys Trp Ile Cys 
            180                 185                 

<210> 47
<211> 293
<212> PRT
<213> Artificial Sequence


<220> 
<223> Xeno.RBD

<400> 47
Met Glu Gly Ser Ala Phe Ser Lys Pro Leu Lys Asp Lys Ile Asn Pro 
1               5                   10                  15      
Trp Gly Pro Leu Ile Val Met Gly Ile Leu Val Arg Ala Gly Ala Ser 
            20                  25                  30          
Val Gln Arg Asp Ser Pro His Gln Ile Phe Asn Val Thr Trp Arg Val 
        35                  40                  45              
Thr Asn Leu Met Thr Gly Gln Thr Ala Asn Ala Thr Ser Leu Leu Gly 
    50                  55                  60                  
Thr Met Thr Asp Thr Phe Pro Lys Leu Tyr Phe Asp Leu Cys Asp Leu 
65                  70                  75                  80  
Val Gly Asp Tyr Trp Asp Asp Pro Glu Pro Asp Ile Gly Asp Gly Cys 
                85                  90                  95      
Arg Thr Pro Gly Gly Arg Arg Arg Thr Arg Leu Tyr Asp Phe Tyr Val 
            100                 105                 110         
Cys Pro Gly His Thr Val Pro Ile Gly Cys Gly Gly Pro Gly Glu Gly 
        115                 120                 125             
Tyr Cys Gly Lys Trp Gly Cys Glu Thr Thr Gly Gln Ala Tyr Trp Lys 
    130                 135                 140                 
Pro Ser Ser Ser Trp Asp Leu Ile Ser Leu Lys Arg Gly Asn Thr Pro 
145                 150                 155                 160 
Lys Asp Gln Gly Pro Cys Tyr Asp Ser Ser Val Ser Ser Gly Val Gln 
                165                 170                 175     
Gly Ala Thr Pro Gly Gly Arg Cys Asn Pro Leu Val Leu Glu Phe Thr 
            180                 185                 190         
Asp Ala Gly Arg Lys Ala Ser Trp Asp Ala Pro Lys Val Trp Gly Leu 
        195                 200                 205             
Arg Leu Tyr Arg Ser Thr Gly Ala Asp Pro Val Thr Arg Phe Ser Leu 
    210                 215                 220                 
Thr Arg Gln Val Leu Asn Val Gly Pro Arg Val Pro Ile Gly Pro Asn 
225                 230                 235                 240 
Pro Val Ile Thr Asp Gln Leu Pro Pro Ser Gln Pro Val Gln Ile Met 
                245                 250                 255     
Leu Pro Arg Pro Pro His Pro Pro Pro Ser Gly Thr Val Ser Met Val 
            260                 265                 270         
Pro Gly Ala Pro Pro Pro Ser Gln Gln Pro Gly Thr Gly Asp Arg Leu 
        275                 280                 285             
Leu Asn Leu Val Glu 
    290             

<210> 48
<211> 238
<212> PRT
<213> Artificial Sequence


<220> 
<223> Xeno.RBD

<400> 48
Met Glu Gly Ser Ala Phe Ser Lys Pro Leu Lys Asp Lys Ile Asn Pro 
1               5                   10                  15      
Trp Gly Pro Leu Ile Val Met Gly Ile Leu Val Arg Ala Gly Ala Ser 
            20                  25                  30          
Val Gln Arg Asp Ser Pro His Gln Ile Phe Asn Val Thr Trp Arg Val 
        35                  40                  45              
Thr Asn Leu Met Thr Gly Gln Thr Ala Asn Ala Thr Ser Leu Leu Gly 
    50                  55                  60                  
Thr Met Thr Asp Thr Phe Pro Lys Leu Tyr Phe Asp Leu Cys Asp Leu 
65                  70                  75                  80  
Val Gly Asp Tyr Trp Asp Asp Pro Glu Pro Asp Ile Gly Asp Gly Cys 
                85                  90                  95      
Arg Thr Pro Gly Gly Arg Arg Arg Thr Arg Leu Tyr Asp Phe Tyr Val 
            100                 105                 110         
Cys Pro Gly His Thr Val Pro Ile Gly Cys Gly Gly Pro Gly Glu Gly 
        115                 120                 125             
Tyr Cys Gly Lys Trp Gly Cys Glu Thr Thr Gly Gln Ala Tyr Trp Lys 
    130                 135                 140                 
Pro Ser Ser Ser Trp Asp Leu Ile Ser Leu Lys Arg Gly Asn Thr Pro 
145                 150                 155                 160 
Lys Asp Gln Gly Pro Cys Tyr Asp Ser Ser Val Ser Ser Gly Val Gln 
                165                 170                 175     
Gly Ala Thr Pro Gly Gly Arg Cys Asn Pro Leu Val Leu Glu Phe Thr 
            180                 185                 190         
Asp Ala Gly Arg Lys Ala Ser Trp Asp Ala Pro Lys Val Trp Gly Leu 
        195                 200                 205             
Arg Leu Tyr Arg Ser Thr Gly Ala Asp Pro Val Thr Arg Phe Ser Leu 
    210                 215                 220                 
Thr Arg Gln Val Leu Asn Val Gly Pro Arg Val Pro Ile Gly 
225                 230                 235             

<210> 49
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> RD114.RBD

<400> 49
Met Lys Leu Pro Ala Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      
Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          
Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              
Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  
Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Asn Leu 
65                  70                  75                  80  
Thr Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln 
                85                  90                  95      
Asp Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Ala 
            100                 105                 110         
Asn Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly 
        115                 120                 125             
Ser Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln 
    130                 135                 140                 
Ser Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr 
145                 150                 155                 160 
Ala Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg 
                165                 170                 175     
Val Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met His 
            180                 185                 190         
Pro Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp 
        195                 200                 205             
Leu Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe 
    210                 215                 220             

<210> 50
<211> 993
<212> DNA
<213> Artificial Sequence


<220> 
<223> RD114.RBD

<400> 50
atgaaacccc cagcgggaat ggtctttctg tgggtcctca caagcttggg ggcgggaatt      60

ggagctaaaa ttgtcaaaga ggggaaccca catcaggttt ataccttgac ttggcaaatc     120

tactcccaga gcggggaagt tgtctgggag gtccaaggta accatgcgct taatacttgg     180

tggcccccac ttacccctga tttttgccag ctggcagctg gattagacac ttgggatatc     240

ccagctagaa gccccaagaa cctgcagtcc tacatggggg aaagaatcca gcagatgact     300

gcccatggat gcagtagtcc cactgccaga tgtagattag cccaggcaga gttctatgtc     360

tgtcctcgag acaataggga tagggccact gcccaccgat gtgggggata tgaagaatat     420

ttctgctcgg catggggctg cgaaactact ggcgatgcct actggcaacc tacctcttcc     480

tgggacttaa tcaccattac aagaggttac accaaacctg accccgatgg acacacttgc     540

tactataaaa agggcacaga agggtatcat cattggataa gtcccctgtc tctacctctt     600

aagattacct ttacagattc aggaaaacgg gctctcggat ggcagacggg ctatacatgg     660

ggactccgat ggtacctacc gggaaaagat agggggattg ttctaaaaat caaattaaaa     720

atagatacaa tcacccaaac cgtaggtccc aacctagtat tggccgatca aaaagctccg     780

gtccagctag ccatcccagt ccagccacca agggccccaa ctcagacacc gggaattaac     840

cctgttaatt ccactctaag ccccagtcta ggatacccga ccccccctct cgaccgggca     900

caaggagata ggctcctaaa ccttgtacaa ggggtatact taactctcaa ccttacggcc     960

ccaaatcaaa ctcaggactg ttggctctgc cta                                  993


<210> 51
<211> 352
<212> PRT
<213> Artificial Sequence


<220> 
<223> HERV-W.RBD fused to a mouse Fc fragment

<400> 51
Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Leu Leu Pro Ser 
1               5                   10                  15      
Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          
Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              
Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  
His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  
His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      
Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         
Gly Met Ser Asp Gly Gly Gly Val Gln Gly Ser Val Asp Val Pro Arg 
        115                 120                 125             
Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
    130                 135                 140                 
Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
145                 150                 155                 160 
Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
                165                 170                 175     
Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
            180                 185                 190         
Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
        195                 200                 205             
Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
    210                 215                 220                 
Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 
Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
                245                 250                 255     
Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
            260                 265                 270         
Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
        275                 280                 285             
Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
    290                 295                 300                 
Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
305                 310                 315                 320 
Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
                325                 330                 335     
Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
            340                 345                 350         



<210> 52
<211> 470
<212> PRT
<213> Artificial Sequence


<220> 
<223> Xeno.RBD fused to a rabbit Fc fragment

<400> 52
Met Leu Val Met Glu Gly Ser Ala Phe Ser Lys Pro Leu Lys Asp Lys 
1               5                   10                  15      
Ile Asn Pro Trp Gly Pro Leu Ile Val Met Gly Ile Leu Val Arg Ala 
            20                  25                  30          
Gly Ala Ser Val Gln Arg Asp Ser Pro His Gln Ile Phe Asn Val Thr 
        35                  40                  45              
Trp Arg Val Thr Asn Leu Met Thr Gly Gln Thr Ala Asn Ala Thr Ser 
    50                  55                  60                  
Leu Leu Gly Thr Met Thr Asp Thr Phe Pro Lys Leu Tyr Phe Asp Leu 
65                  70                  75                  80  
Cys Asp Leu Val Gly Asp Tyr Trp Asp Asp Pro Glu Pro Asp Ile Gly 
                85                  90                  95      
Asp Gly Cys Arg Thr Pro Gly Gly Arg Arg Arg Thr Arg Leu Tyr Asp 
            100                 105                 110         
Phe Tyr Val Cys Pro Gly His Thr Val Pro Ile Gly Cys Gly Gly Pro 
        115                 120                 125             
Gly Glu Gly Tyr Cys Gly Lys Trp Gly Cys Glu Thr Thr Gly Gln Ala 
    130                 135                 140                 
Tyr Trp Lys Pro Ser Ser Ser Trp Asp Leu Ile Ser Leu Lys Arg Gly 
145                 150                 155                 160 
Asn Thr Pro Lys Asp Gln Gly Pro Cys Tyr Asp Ser Ser Val Ser Ser 
                165                 170                 175     
Gly Val Gln Gly Ala Thr Pro Gly Gly Arg Cys Asn Pro Leu Val Leu 
            180                 185                 190         
Glu Phe Thr Asp Ala Gly Arg Lys Ala Ser Trp Asp Ala Pro Lys Val 
        195                 200                 205             
Trp Gly Leu Arg Leu Tyr Arg Ser Thr Gly Ala Asp Pro Val Thr Arg 
    210                 215                 220                 
Phe Ser Leu Thr Arg Gln Val Leu Asn Val Gly Pro Arg Val Pro Ile 
225                 230                 235                 240 
Gly Ser Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu 
                245                 250                 255     
Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             
Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn 
    290                 295                 300                 
Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn 
305                 310                 315                 320 
Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Thr His Gln Asp Trp 
                325                 330                 335     
Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro 
            340                 345                 350         
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu 
        355                 360                 365             
Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg 
    370                 375                 380                 
Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 
Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr 
                405                 410                 415     
Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Asn Lys 
            420                 425                 430         
Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys 
        435                 440                 445             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile 
    450                 455                 460                 
Ser Arg Ser Pro Gly Lys 
465                 470 

<210> 53
<211> 523
<212> PRT
<213> Artificial Sequence


<220> 
<223> Xeno.RBD fused to a rabbit Fc fragment

<400> 53
Met Glu Gly Ser Ala Phe Ser Lys Pro Leu Lys Asp Lys Ile Asn Pro 
1               5                   10                  15      
Trp Gly Pro Leu Ile Val Met Gly Ile Leu Val Arg Ala Gly Ala Ser 
            20                  25                  30          
Val Gln Arg Asp Ser Pro His Gln Ile Phe Asn Val Thr Trp Arg Val 
        35                  40                  45              
Thr Asn Leu Met Thr Gly Gln Thr Ala Asn Ala Thr Ser Leu Leu Gly 
    50                  55                  60                  
Thr Met Thr Asp Thr Phe Pro Lys Leu Tyr Phe Asp Leu Cys Asp Leu 
65                  70                  75                  80  
Val Gly Asp Tyr Trp Asp Asp Pro Glu Pro Asp Ile Gly Asp Gly Cys 
                85                  90                  95      
Arg Thr Pro Gly Gly Arg Arg Arg Thr Arg Leu Tyr Asp Phe Tyr Val 
            100                 105                 110         
Cys Pro Gly His Thr Val Pro Ile Gly Cys Gly Gly Pro Gly Glu Gly 
        115                 120                 125             
Tyr Cys Gly Lys Trp Gly Cys Glu Thr Thr Gly Gln Ala Tyr Trp Lys 
    130                 135                 140                 
Pro Ser Ser Ser Trp Asp Leu Ile Ser Leu Lys Arg Gly Asn Thr Pro 
145                 150                 155                 160 
Lys Asp Gln Gly Pro Cys Tyr Asp Ser Ser Val Ser Ser Gly Val Gln 
                165                 170                 175     
Gly Ala Thr Pro Gly Gly Arg Cys Asn Pro Leu Val Leu Glu Phe Thr 
            180                 185                 190         
Asp Ala Gly Arg Lys Ala Ser Trp Asp Ala Pro Lys Val Trp Gly Leu 
        195                 200                 205             
Arg Leu Tyr Arg Ser Thr Gly Ala Asp Pro Val Thr Arg Phe Ser Leu 
    210                 215                 220                 
Thr Arg Gln Val Leu Asn Val Gly Pro Arg Val Pro Ile Gly Pro Asn 
225                 230                 235                 240 
Pro Val Ile Thr Asp Gln Leu Pro Pro Ser Gln Pro Val Gln Ile Met 
                245                 250                 255     
Leu Pro Arg Pro Pro His Pro Pro Pro Ser Gly Thr Val Ser Met Val 
            260                 265                 270         
Pro Gly Ala Pro Pro Pro Ser Gln Gln Pro Gly Thr Gly Asp Arg Leu 
        275                 280                 285             
Leu Asn Leu Val Glu Gly Ser Ala Pro Ser Thr Cys Ser Lys Pro Thr 
    290                 295                 300                 
Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
305                 310                 315                 320 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                325                 330                 335     
Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr 
            340                 345                 350         
Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg 
        355                 360                 365             
Glu Gln Gln Phe Asp Cys Thr Ile Arg Val Val Ser Thr Leu Pro Ile 
    370                 375                 380                 
Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His 
385                 390                 395                 400 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg 
                405                 410                 415     
Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu 
            420                 425                 430         
Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe 
        435                 440                 445             
Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu 
    450                 455                 460                 
Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr 
465                 470                 475                 480 
Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly 
                485                 490                 495     
Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         
Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
        515                 520             

<210> 54
<211> 453
<212> PRT
<213> Artificial Sequence


<220> 
<223> RD114.RBD fused to a mouse Fc fragment

<400> 54
Met Lys Leu Pro Thr Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      
Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          
Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              
Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  
Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Ile Ser 
65                  70                  75                  80  
Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln Asp 
                85                  90                  95      
Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Arg Ile 
            100                 105                 110         
Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly Ser 
        115                 120                 125             
Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln Ser 
    130                 135                 140                 
Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr Ala 
145                 150                 155                 160 
Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg Val 
                165                 170                 175     
Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met Thr Pro 
            180                 185                 190         
Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp Leu 
        195                 200                 205             
Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe Gly Ser 
    210                 215                 220                 
Val Asp Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
225                 230                 235                 240 
Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
                245                 250                 255     
Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
            260                 265                 270         
Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
        275                 280                 285             
Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 
Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
305                 310                 315                 320 
Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
            340                 345                 350         
Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
        355                 360                 365             
Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
    370                 375                 380                 
Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
385                 390                 395                 400 
Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
                405                 410                 415     
Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
            420                 425                 430         
Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
        435                 440                 445             
His Ser Pro Gly Lys 
    450             

<210> 55
<211> 454
<212> PRT
<213> Artificial Sequence


<220> 
<223> RD114.RBD fused to a mouse Fc fragment

<400> 55
Met Lys Leu Pro Ala Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      
Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          
Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              
Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  
Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Asn Leu 
65                  70                  75                  80  
Thr Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln 
                85                  90                  95      
Asp Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Ala 
            100                 105                 110         
Asn Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly 
        115                 120                 125             
Ser Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln 
    130                 135                 140                 
Ser Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr 
145                 150                 155                 160 
Ala Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg 
                165                 170                 175     
Val Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met His 
            180                 185                 190         
Pro Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp 
        195                 200                 205             
Leu Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe Gly 
    210                 215                 220                 
Ser Val Asp Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
225                 230                 235                 240 
Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     
Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
            260                 265                 270         
Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
        275                 280                 285             
Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 
Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
305                 310                 315                 320 
Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
            340                 345                 350         
Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
        355                 360                 365             
Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
    370                 375                 380                 
Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
385                 390                 395                 400 
Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
                405                 410                 415     
Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
            420                 425                 430         
Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
        435                 440                 445             
Ser His Ser Pro Gly Lys 
    450                 

