               SEQUENCE LISTING

<110> FredAx AB

<120> ANTIBODY POLYPEPTIDES AND USES THEREOF

<130> FREBA/P61995PC

<160> 23

<170> BiSSAP 1.2

<210> 1
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain variable region CDRH1

<400> 1
Thr Thr Gly Met Gly Val Ser 
1               5           

<210> 2
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain variable region CDRH2

<400> 2
His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Thr Ser Leu Lys 
1               5                   10                  15  

<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain variable region CDRH3

<400> 3
Lys Gly Tyr Tyr Gly Tyr Phe Asp Tyr 
1               5                   

<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region CDRL1

<400> 4
Arg Ala Ser Gln Asn Val Asn Thr Asp Val Ala 
1               5                   10      

<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region CDRL2

<400> 5
Ser Thr Ser Tyr Leu Gln Ser 
1               5           

<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region CDRL3

<400> 6
Gln Gln Tyr Ser Asn Tyr Pro Leu Thr 
1               5                   

<210> 7
<211> 244
<212> PRT
<213> Homo sapiens

<220> 
<223> Amino acid sequence of human PSA

<400> 7
Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu Lys 
1               5                   10                  15      
His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala Val 
            20                  25                  30          
Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala His 
        35                  40                  45              
Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu Phe 
    50                  55                  60                  
His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe Pro 
65                  70                  75                  80  
His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg Pro 
                85                  90                  95      
Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro 
            100                 105                 110         
Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln Glu 
        115                 120                 125             
Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile Glu 
    130                 135                 140                 
Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu His 
145                 150                 155                 160 
Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val Thr 
                165                 170                 175     
Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr Cys 
            180                 185                 190         
Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln Gly 
        195                 200                 205             
Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro Ser 
    210                 215                 220                 
Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr Ile 
225                 230                 235                 240 
Val Ala Asn Pro 
                

<210> 8
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain variable region amino acid sequence

<400> 8
Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Thr 
            20                  25                  30          
Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Thr Ser 
    50                  55                  60                  
Leu Lys Thr Arg Leu Thr Ile Ser Glu Asp Ser Ser Lys Asn Gln Val 
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Lys Gly Tyr Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region amino acid sequence

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Asn Val Asn Thr Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              
Phe Ser Thr Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 10
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody amino acid sequence

<400> 10
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 11
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody amino acid sequence

<400> 11
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     

<210> 12
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain amino acid sequence

<400> 12
Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Thr 
            20                  25                  30          
Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Thr Ser 
    50                  55                  60                  
Leu Lys Thr Arg Leu Thr Ile Ser Glu Asp Ser Ser Lys Asn Gln Val 
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Lys Gly Tyr Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210> 13
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain amino acid sequence

<400> 13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Asn Val Asn Thr Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              
Phe Ser Thr Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 14
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..357
<223> /mol_type="unassigned DNA"
      /note="Nucleic acid sequence"
      /organism="Artificial Sequence"

<400> 14
caggtcacac tgaaggaatc tgggcctgct ttggtgaagc ccactcagac tctgacactc      60

acatgcacct tctccgggtt tagcctgtca accaccggta tgggcgtgag ttggattcgc     120

caaccaccgg gtaaagcgct tgagtggctt gcacacatct attgggacga tgacaagcgg     180

tacagtacta gcctgaaaac gagactgacc ataagcgagg actcatccaa gaatcaggtg     240

gtactgacga tgaccaacat ggatcccgtt gataccgcca catactactg tgccaggaaa     300

ggctactatg gctatttcga ctattgggga cagggaacac tcgtcactgt gtcctct        357


<210> 15
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..324
<223> /mol_type="unassigned DNA"
      /note="Nucleic acid sequence"
      /organism="Artificial Sequence"

<400> 15
gacatccaga tgacccaatc tccctctagc ttgtccgcta gtgtcggtga tagggtgaca      60

gtgacatgca gagctagcca gaatgtcaac acagacgttg cctggtatca gcagaagcca     120

ggcaaagcac ccaaagccct catcttctcc acgtcatatc tgcaaagcgg agtaccttcc     180

cggtttagtg ggtctgggtc aggcactgac ttcaccctga ccatatccag ccttcaaccg     240

gaagatttcg cgacctacta ctgtcagcag tacagcaact atcctctgac ttttggacag     300

ggcactaagg tggagattaa gcgt                                            324


<210> 16
<211> 1350
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1350
<223> /mol_type="unassigned DNA"
      /note="Nucleic acid sequence"
      /organism="Artificial Sequence"

<400> 16
caggtcacac tgaaggaatc tgggcctgct ttggtgaagc ccactcagac tctgacactc      60

acatgcacct tctccgggtt tagcctgtca accaccggta tgggcgtgag ttggattcgc     120

caaccaccgg gtaaagcgct tgagtggctt gcacacatct attgggacga tgacaagcgg     180

tacagtacta gcctgaaaac gagactgacc ataagcgagg actcatccaa gaatcaggtg     240

gtactgacga tgaccaacat ggatcccgtt gataccgcca catactactg tgccaggaaa     300

ggctactatg gctatttcga ctattgggga cagggaacac tcgtcactgt gtcctctgct     360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc     420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg     480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa     660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg     720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag     780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa    1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg    1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc    1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg    1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag    1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag    1320

aagagcctct ccctgtctcc gggtaaatga                                     1350


<210> 17
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..642
<223> /mol_type="unassigned DNA"
      /note="Nucleic acid sequence"
      /organism="Artificial Sequence"

<400> 17
gacatccaga tgacccaatc tccctctagc ttgtccgcta gtgtcggtga tagggtgaca      60

gtgacatgca gagctagcca gaatgtcaac acagacgttg cctggtatca gcagaagcca     120

ggcaaagcac ccaaagccct catcttctcc acgtcatatc tgcaaagcgg agtaccttcc     180

cggtttagtg ggtctgggtc aggcactgac ttcaccctga ccatatccag ccttcaaccg     240

gaagatttcg cgacctacta ctgtcagcag tacagcaact atcctctgac ttttggacag     300

ggcactaagg tggagattaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca     360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                        642


<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> N terminal amino acid sequence from light chain of antibody

<400> 18
Asp Ile Val Met Thr Gln Ser 
1               5           

<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> N terminal amino acid sequence from heavy chain of antibody

<400> 19
Glu Val Gln Leu Val Glu Ser Gly 
1               5               

<210> 20
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..35
<223> /mol_type="unassigned DNA"
      /note="Light chain primer 5A10-L "
      /organism="Artificial Sequence"

<400> 20
ccagccatgg ctgacattgt gatgacccag tctca                                35


<210> 21
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..34
<223> /mol_type="unassigned DNA"
      /note="Light chain primer WO252"
      /organism="Artificial Sequence"

<400> 21
gcgccgtcta gaattaacac tcattcctgt tgaa                                 34


<210> 22
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..35
<223> /mol_type="unassigned DNA"
      /note="Fd chain primer 5A10-H "
      /organism="Artificial Sequence"

<400> 22
ccagccatgg ctgaggtgca attggtggag tctgg                                35


<210> 23
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="Fd chain primer WO267"
      /organism="Artificial Sequence"

<400> 23
ctagactagt acaatccctg ggcacaattt tc                                   32


