
                                SEQUENCE LISTING

<110> CELGENE CORPORATION

<120> TLR MODULATORS AND METHODS OF USE
  
<130> 14247-056-228

<140> TBA
<141> On even date herewith

<150> 62/235,475          
<151> 2015-09-30

<150> 62/360,256          
<151> 2016-07-08  

<160> 158

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1281
<212> DNA
<213> Homo sapiens

<220> 
<223> human SMAD family member 7 (SMAD7) variant 1 mRNA

<400> 1
atgttcagga ccaaacgatc tgcgctcgtc cggcgtctct ggaggagccg tgcgcccggc 60
ggcgaggacg aggaggaggg cgcaggggga ggtggaggag gaggcgagct gcggggagaa 120
ggggcgacgg acagccgagc gcatggggcc ggtggcggcg gcccgggcag ggctggatgc 180
tgcctgggca aggcggtgcg aggtgccaaa ggtcaccacc atccccaccc gccagccgcg 240
ggcgccggcg cggccggggg cgccgaggcg gatctgaagg cgctcacgca ctcggtgctc 300
aagaaactga aggagcggca gctggagctg ctgctccagg ccgtggagtc ccgcggcggg 360
acgcgcaccg cgtgcctcct gctgcccggc cgcctggact gcaggctggg cccgggggcg 420
cccgccggcg cgcagcctgc gcagccgccc tcgtcctact cgctccccct cctgctgtgc 480
aaagtgttca ggtggccgga tctcaggcat tcctcggaag tcaagaggct gtgttgctgt 540
gaatcttacg ggaagatcaa ccccgagctg gtgtgctgca acccccatca ccttagccga 600
ctctgcgaac tagagtctcc cccccctcct tactccagat acccgatgga ttttctcaaa 660
ccaactgcag actgtccaga tgctgtgcct tcctccgctg aaacaggggg aacgaattat 720
ctggcccctg gggggctttc agattcccaa cttcttctgg agcctgggga tcggtcacac 780
tggtgcgtgg tggcatactg ggaggagaag acgagagtgg ggaggctcta ctgtgtccag 840
gagccctctc tggatatctt ctatgatcta cctcagggga atggcttttg cctcggacag 900
ctcaattcgg acaacaagag tcagctggtg cagaaggtgc ggagcaaaat cggctgcggc 960
atccagctga cgcgggaggt ggatggtgtg tgggtgtaca accgcagcag ttaccccatc 1020
ttcatcaagt ccgccacact ggacaacccg gactccagga cgctgttggt acacaaggtg 1080
ttccccggtt tctccatcaa ggctttcgac tacgagaagg cgtacagcct gcagcggccc 1140
aatgaccacg agtttatgca gcagccgtgg acgggcttta ccgtgcagat cagctttgtg 1200
aagggctggg gccagtgcta cacccgccag ttcatcagca gctgcccgtg ctggctagag 1260
gtcatcttca acagccggta g                                           1281

<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 2
gtcgcccctt ctccccgcag                                             20

<210> 3
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 3
gtcgcccctt ctccccgcag c                                           21

<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = 5-methyl 2'-deoxycytidine

<400> 4
gtngcccctt ctcccngcag                                             20

<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = 5-methyl 2'-deoxycytidine

<400> 5
gtngcccctt ctcccngcag c                                           21

<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = nucleoside comprising a nitrogenous base selected from
the group consisting of cytosine, 5-methylcytosine and 
2-O-methylcytosine

<220> 
<221> misc_feature   
<222> 4, 17
<223> n = nucleoside comprising a nitrogenous base selected from
the group consisting of guanine, 5-methylguanine and 
2-O-methylguanine

<400> 6
gtnncccctt ctcccnncag                                             20

<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = nucleoside comprising 5-methyl 2'-deoxycytidine

<400> 7
gtngcccctt ctcccngcag c                                           21

<210> 8
<211> 3111
<212> DNA
<213> Homo sapiens

<220> 
<223> human SMAD 7 sequence (GenBank AF0010193)

<400> 8
ggcacgagcg gagagccgcg cagggcgcgg gccgcgcggg gtggggcagc cggagcgcag 60
gcccccgatc cccggcgggc gcccccgggc ccccgcgcgc gccccggcct ccgggagact 120
ggcgcatgcc acggagcgcc cctcgggccg ccgccgctcc tgcccgggcc cctgctgctg 180
ctgctgtcgc ctgcgcctgc tgccccaact cggcgcccga cttcttcatg gtgtgcggag 240
gtcatgttcg ctccttagca ggcaaacgac ttttctcctc gcctcctcgc cccgcatgtt 300
caggaccaaa cgatctgcgc tcgtccggcg tctctggagg agccgtgcgc ccggcggcga 360
ggacgaggag gagggcgcag ggggaggtgg aggaggaggc gagctgcggg gagaaggggc 420
gacggacagc cgagcgcatg gggccggtgg cggcggcccg ggcagggctg gatgctgcct 480
gggcaaggcg gtgcgaggtg ccaaaggtca ccaccatccc cacccgccag ccgcgggcgc 540
cggcgcggcc gggggcgccg aggcggatct gaaggcgctc acgcactcgg tgctcaagaa 600
actgaaggag cggcagctgg agctgctgct ccaggccgtg gagtcccgcg gcgggacgcg 660
caccgcgtgc ctcctgctgc ccggccgcct ggactgcagg ctgggcccgg gggcgcccgc 720
cggcgcgcag cctgcgcagc cgccctcgtc ctactcgctc cccctcctgc tgtgcaaagt 780
gttcaggtgg ccggatctca ggcattcctc ggaagtcaag aggctgtgtt gctgtgaatc 840
ttacgggaag atcaaccccg agctggtgtg ctgcaacccc catcacctta gccgactctg 900
cgaactagag tctccccccc ctccttactc cagatacccg atggattttc tcaaaccaac 960
tgcagactgt ccagatgctg tgccttcctc cgctgaaaca gggggaacga attatctggc 1020
ccctgggggg ctttcagatt cccaacttct tctggagcct ggggatcggt cacactggtg 1080
cgtggtggca tactgggagg agaagacgag agtggggagg ctctactgtg tccaggagcc 1140
ctctctggat atcttctatg atctacctca ggggaatggc ttttgcctcg gacagctcaa 1200
ttcggacaac aagagtcagc tggtgcagaa ggtgcggagc aaaatcggct gcggcatcca 1260
gctgacgcgg gaggtggatg gtgtgtgggt gtacaaccgc agcagttacc ccatcttcat 1320
caagtccgcc acactggaca acccggactc caggacgctg ttggtacaca aggtgttccc 1380
cggtttctcc atcaaggctt tcgactacga gaaggcgtac agcctgcagc ggcccaatga 1440
ccacgagttt atgcagcagc cgtggacggg ctttaccgtg cagatcagct ttgtgaaggg 1500
ctggggtcag tgctacaccc gccagttcat cagcagctgc ccgtgctggc tagaggtcat 1560
cttcaacagc cggtagccgc gtgcggaggg gacagagcgt gagctgagca ggccacactt 1620
caaactactt tgctgctaat attttcctcc tgagtgcttg cttttcatgc aaactctttg 1680
gtcgtttttt ttttgtttgt tggttggttt tcttcttctc gtcctcgttt gtgttctgtt 1740
ttgtttcgct ctttgagaaa tagcttatga aaagaattgt tgggggtttt tttggaagaa 1800
ggggcaggta tgatcggcag gacaccctga taggaagagg ggaagcagaa atccaagcac 1860
caccaaacac agtgtatgaa ggggggcggt catcatttca cttgtcagga gtgtgtgtga 1920
gtgtgagtgt gcggctgtgt gtgcacgcgt gtgcaggagc ggcagatggg gagacaacgt 1980
gctctttgtt ttgtgtctct tatggatgtc cccagcagag aggtttgcag tcccaagcgg 2040
tgtctctcct gccccttgga cacgctcagt ggggcagagg cagtacctgg gcaagctggc 2100
ggctggggtc ccagcagctg ccaggagcac ggctctgtcc ccagcctggg aaagcccctg 2160
cccctcctct ccctcatcaa ggacacgggc ctgtccacag gcttctgagc agcgagcctg 2220
ctagtggccg aaccagaacc aattattttc atccttgtct tattcccttc ctgccagccc 2280
ctgccattgt agcgtctttc ttttttggcc atctgctcct ggatctccct gagatgggct 2340
tcccaagggc tgccggggca gccccctcac agtattgctc acccagtgcc ctctcccctc 2400
agcctctccc ctgcctgccc tggtgacatc aggtttttcc cggacttaga aaaccagctc 2460
agcactgcct gctcccatcc tgtgtgttaa gctctgctat taggccagca agcggggatg 2520
tccctgggag ggacatgctt agcagtcccc ttccctccaa gaaggatttg gtccgtcata 2580
acccaaggta ccatcctagg ctgacaccta actcttcttt catttcttct acaactcata 2640
cactcgtatg atacttcgac actgttctta gctcaatgag catgtttaga ctttaacata 2700
agctattttt ctaactacaa aggtttaaat gaacaagaga agcattctca ttggaaattt 2760
agcattgtag tgctttgaga gagaaaggac tcctgaaaaa aaacctgaga tttattaaag 2820
aaaaaaatgt attttatgtt atatataaat atattattac ttgtaaatat aaagacgttt 2880
tataagcatc attatttatg tattgtgcaa tgtgtataaa caagaaaaat aaagaaaaga 2940
tgcactttgc tttaatataa atgcaaataa caaatgccaa attaaaaaag ataaacacaa 3000
gattggtgtt ttttcctatg ggtgttatca cctagctgaa tgtttttcta aaggagttta 3060
tgttccatta aacgattttt aaaatgtaca cttgaaaaaa aaaaaaaaaa a          3111

<210> 9
<211> 3681
<212> DNA
<213> Mus musculus

<220> 
<223> mouse SMAD7 mRNA (GenBank NM_008543)

<400> 9
cgagtgcggc gcggcgagcc cccagcggcg gcagaaggac tcgagcgcca ggagagggcg 60
gacgggggac gaggaggctc cggggcgcga cgaagagagt ctccgaggaa gaggctgcga 120
gaggacaccc gggcctcctg ccgccactgt cgggtcgggg ccagcagctc atgagagcag 180
ccccggcggc cacccgcggc caggagaagg agcaccggag gcccccacac tagcctgtgc 240
cctcgggggc gagagcttgc gacccgccgg agcccgccgc cgcgccgccc tcccccgcgc 300
tgacagcccc ccggggcgca gccgccgccg cagcatcttc tgtccctgct tccccagcgc 360
ggaggaagtc cccgccgagg acctgagccc ccgggaacgc aggaggaaag accagagact 420
ctaaaacacc cagatacgca agattgaagc agcctagcca gacctttctg tggattaaaa 480
gaaatacgat tttttttttt tttttttggc agaagaaaag gaaaggaaga ccggctgggt 540
tcagcaagga aaaaaagggg gatgtaactc gtggatacgg tttttttccc ccacccttcc 600
aacatcttgt tttattttgt aaacattttc tcttttaaac ccgggctcca tccggtgccc 660
tccagacctc cgaggtgcga ggaggtggtg tgttttttca ttgggggctt tgcatatttt 720
ggttttgggg gttttgagag accctccaga catctcacga ggggtgaagt ctactcggtc 780
ccctcccgca agtcttcgcg tgcacagaat tcgaggagat ccggttacta aggatataga 840
agaaaaaaaa taaatcgtgc ctgccttttt tttttaattg cctgcttctc cccaccccca 900
aattaagttg cttagcaagg gggaaagagg ctttttcctc cctttagtag ctcagcctaa 960
cgtctttcgt tttttttttt tttttttttt ttttgccccc gaggatcttc catgtaggaa 1020
gccgaggctg gcgagcccga cactcgggag ccactgtagg ggggcctttt ttgggggagg 1080
cgtctaccgg ggttgcctcg gccgccccca gggaagcggc ggccgcgttc ctccagggca 1140
cgccggggcc cgaaagccgc gcagggcgcg ggccgcgccg ggtggggcag ccgaagcgca 1200
gccccccgat ccccggcagg cgcccctggg cccccgcgcg cgccccggcc tctgggagac 1260
tggcgcatgc cacggagcgc ccctcgggcc gccgccgctt ctgcccgggc ccctgctgtt 1320
gctgctgtcg cctgcgcctg ctgccccaac tcggcgcccg acttcttcat ggtgtgcgga 1380
ggtcatgttc gctccttagc cggcaaacga cttttctcct cgcctcctcg ccccgcatgt 1440
tcaggaccaa acgatctgcg ctcgtccggc gtctctggag gagccgtgcg cccggcggcg 1500
aggacgagga ggagggcgtg gggggtggcg gcggaggagg cgagctgcgg ggagaagggg 1560
cgacggacgg ccgggcttat ggggctggtg gcggcggtgc gggcagggct ggctgctgcc 1620
tgggcaaggc agtccgaggt gccaaaggtc accaccatcc ccatccccca acctcgggtg 1680
ccggggcggc cgggggcgcc gaggcggatc tgaaggcgct cacgcactcg gtgctcaaga 1740
aactcaagga gcggcagctg gagctgctgc ttcaggccgt ggagtcccgc ggcggtacgc 1800
gcaccgcgtg cctcctgctg cccggccgcc tggactgcag gctgggcccg ggggcgcccg 1860
ccagcgcgca gcccgcgcag ccgccctcgt cctactcgct ccccctcctg ctgtgcaaag 1920
tgttcaggtg gccggatctc aggcattcct cggaagtcaa gaggctgtgt tgctgtgaat 1980
cttacgggaa gatcaacccc gagctggtgt gctgcaaccc ccatcacctt agtcgactct 2040
gtgaactaga gtctccccct cctccttact ccagataccc aatggatttt ctcaaaccaa 2100
ctgcaggctg tccagatgct gtaccttcct ccgcggaaac cgggggaacg aattatctgg 2160
cccctggggg gctttcagat tcccaacttc ttctggagcc tggggatcgg tcacactggt 2220
gcgtggtggc atactgggag gagaagactc gcgtggggag gctctactgt gtccaagagc 2280
cctccctgga tatcttctat gatctacctc aggggaatgg cttttgcctc ggacagctca 2340
attcggacaa caagagtcag ctggtacaga aagtgcggag caagatcggc tgtggcatcc 2400
agctgacgcg ggaagtggat ggcgtgtggg tttacaaccg cagcagttac cccatcttca 2460
tcaagtccgc cacactggac aacccggact ccaggacgct gttggtgcac aaagtgttcc 2520
ctggtttctc catcaaggct tttgactatg agaaagccta cagcctgcag cggcccaatg 2580
accacgagtt catgcagcaa ccatggacgg gtttcaccgt gcagatcagc tttgtgaagg 2640
gctggggcca gtgctacacc cgccagttca tcagcagctg cccgtgctgg ctggaggtca 2700
tcttcaacag ccggtagtcg gtcgtgtggt ggggagaaga ggacagggcg gatcgtgagc 2760
cgagcaggcc accgttcaaa ctacttgctg ctaatctttc ccgagtgatt gcttttcatg 2820
caaactcttt ggttggtgtt gttattgcca ttcattgttg gttttgtttt gttctgttct 2880
ggtttgtttt tttttttttt cctccccaag ggctgccggg acagccccag tcacagtatt 2940
gctaccccag taccctctca ggcccttcca ccgggtccca gccgtggtgg ttttttcatc 3000
aggtttctcc cagatgtgga aagtcagctc agcatcccat cccccatcct gtgtgctgag 3060
ctctgtagac cagcgagggg catcagggag ggacctgcgc agtgcccccc cttcctgctg 3120
agaagggtgt agccccgtca caacaaaggt accatccctt ggctggctcc cagcccttct 3180
ctcagctcat acgctcgctc gtatgatact ttgacactgt tcttagctca atgagcatgt 3240
ttagaattta acataagcta tttttctaac tacaaaggtt taaatgaaca agagaagcat 3300
tctcattgga aatttagcat tgtagtgctt tgagagagga aaggactcct taaaagaaaa 3360
aaaaagctga gatttattaa agaaaaatgt attttatgtt atatataaat atattattac 3420
ttgtaaatat aaagacgttt tataagcatc attatttatg tattgtgcaa tgtgtataaa 3480
cgagaagaat aaagaaaaga tgcactttgc tttaatataa atgtaaataa catgccaaat 3540
taaaaaaaaa aagataaaca caagattggt gtttttttct atgggtgtta tcacctagct 3600
gaatgttttt ctaaaggagt ttatgttcca ttaaacaatt tttaaaatgt taaaaaaaaa 3660
aaaaaaaaaa aaaaaaaaaa a                                           3681

<210> 10
<211> 4311
<212> DNA
<213> Rattus norvegicus

<220> 
<223> rat SMAD7 mRNA (GenBank NM_030858)

<400> 10
tgagtgcggc gcggcgagcc cccagcggcg gcagaaggac tcgagcgcca ggagagggcg 60
gacgggggac gaggaggctc ccgggcgcga cgaagagagt ctcggaggaa gaggctgcga 120
gaggacaccc gggcctcctg ccgccactgt cgggtcgggg ccagcagctt atgcgagcag 180
ccccagcgac caccctcggc caggagaagg ggcaccggca gcccccacgc tagctagcct 240
gccgcctgtg ccctcggggg cgagagcttg cgacccgccg gagcccgccg ccgcgccgcc 300
ctcccccgcg ctgacagccc cccggggcgc agccgccgcc gcagcatctt ctgtccctgc 360
ttccccagcg cggaggaagt ccccgccgag gacctgggcc cccgggagcg caggaggaaa 420
gaccagagac tctaaaacac ccagatacgc aagattgaag cagcctaacc agacctttct 480
gtggattaaa agaaatacga tttttttttt gacagaagaa aaggaaagga agaccggcgg 540
ggttcagcaa ggaaaaaaag gggatgtaac tcgtggatac ggtttttccc cccacccttc 600
caacatcttg ttctactttg taaacatttt ctctttttaa accccggctc catccggtgc 660
cctccagacc tccgaggtgc gagaaggtgg tgtgtttttt cactgggggc tttgcatatt 720
tggttttggg gtttttgaga gaccctccag acatctcacg aggggtgaag tctactcggc 780
cccctccctc aagtcttcgc gtgcacagaa ttcgaggaga tccggttact aaggatatag 840
aagaaaaaaa taaatcgtgt gcctgccttt ttttttttta attgcctgct tctccccacc 900
cccaaattaa gttgcttagc aagggggaaa gaggcttttt cctcccttca gtagctcagc 960
ctaacgtctt tcgttttttg cccctgagga tcttccatgt aggaagccga ggctggcgag 1020
cccgacactc gggagccact gtaggggggc ctttttgggg agaggcgtcg accggggctg 1080
cctcggccgc ccccagggaa gcggcggccg cgttcctcag gggcacgccg gggcccgaga 1140
gccgcgcagg gcgcgggccg cgccgggtgg ggcagccgaa gcgcaggccc ccgatccccg 1200
gcgggcgccc ctgggccccc gcgcgcgccc cggcctccgg gagactggcg catgccacgg 1260
agcgcccctc gggccgccgc cgcttctgcc cgggcccctg ctgttgttgc tgtcgcctgc 1320
gcctgctgcc ccaactcggc gcccgacttc ttcatggtgt gcggaggtca tgttcgctcc 1380
ttagccggca aacgactttt ctcctcgcct cctcgccccg catgttcagg accaaacgat 1440
ctgcgctcgt ccggcgtctc tggaggagcc gtgcgcccgg cggcgaggac gaggaggagg 1500
gcgtgggggg tggcggcggc ggaggcgacc tgcggggaga aggggcgacg gacggccggg 1560
cttatggggc tggtggcggc ggtgcgggca gggctggctg ctgcctgggt aaggcagtcc 1620
gaggtgccaa aggtcaccac catccccatc ccccatcctc gggtgccggg gcggccgggg 1680
gcgccgaggc ggatctgaag gcgctcacgc actcggtgct caagaaactc aaggagcggc 1740
agctggagct gctgcttcag gccgtggagt cccgcggcgg tacgcgcacc gcgtgcctcc 1800
tgctgcccgg ccgcctggac tgcaggctgg gcccgggggc gcccgccagc gcgcagcccg 1860
cgcagccgcc ctcgtcctac tcgctccccc tcctgctgtg caaagtgttc aggtggccgg 1920
atctcaggca ttcctcggaa gtcaagaggc tgtgttgctg tgaatcttac gggaagatca 1980
accccgagct ggtgtgctgc aacccccatc accttagtcg actctgtgaa ctagagtctc 2040
cccctcctcc ttactccaga tacccgatgg attttctcaa accaactgca gactgtccag 2100
acgctgtacc ttcctccgat gaaaccgggg gaacgaatta tctggcccct ggggggcttt 2160
cagattccca acttcttctg gagcctgggg atcggtcaca ctggtgcgtg gtggcatact 2220
gggaggagaa gactcgagtg gggaggctct actgtgtcca agagccctcc ctggatatct 2280
tctatgatct acctcagggg aatggctttt gcctcggaca gctcaattcg gacaacaaga 2340
gtcagctggt acagaaagtg aggagcaaga tcggctgtgg catccagctg acaagggaag 2400
tggatggcgt gtgggtttac aaccgcagca gttaccccat cttcatcaag tccgccacac 2460
tggacaaccc ggactccagg acgctgttgg tgcacaaagt gttccctggt ttctccatca 2520
aggcttttga ctatgaaaag gcctacagcc tgcagcggcc caatgaccac gagttcatgc 2580
agcagccatg gacgggcttc accgtgcaga ttagcttcgt gaagggctgg ggccagtgct 2640
acacccgcca gttcatcagc agttgcccgt gctggctgga ggtcatcttc aacagccggt 2700
agtctcccgg tgtggggaga agaggacagg acggaggggt gagccgagca ggccaccgtt 2760
caaactactt gctgctaatc tttcatgcaa aactctttcg gtcggttttg ttgtttgcca 2820
ttcattgttg gttctgtttt gttttgtttt cctttttttt ttttcttcct tcttcttttt 2880
cctcctttct tgtcactctt gtgtcctgtg tgtctcgttc tttgagaaaa tatgatgcgg 2940
atttttggtt gtgtgttttt ttttttcgtt tgtttgtttg ttgttgttgt ttgtgttttg 3000
aggtggtggt gggtgcggtt ggcaggacac cccgatacaa aaacgggaag caagagtcag 3060
cactgccaag cgtggtgtgc gaaagtgggt accaccttcc cctttggatc agcatttcag 3120
ttgtcagtgt gtgtgtgtga ggggggtgta cgtgaatgac agatggggga atggcgtgct 3180
ttttttgtgt tctttatgga tgtccccagc tgagaggctt gcagttccaa gctgtgtgtc 3240
tctcactgtg tgtctctctc atgagccttt cggacatgct cggtggggca gaggctgtac 3300
ctgggcagac tggcagcagg tgtcccagca ggtgccgagc tctgctccgc tgaagctccc 3360
ccgcccccgc ccccttcccc acaggacacg ggcctatcca caggcttctg agaagccagc 3420
ctgctagaag gctgaaccag aaccaattgt tttcatccct gtcttactgc ctcctgtcac 3480
ccgctgccat tgtcgaaggc tgtctttttt ggccatctgc tcctggatct ctcttgagat 3540
gggcttccca agggctgccg ggacagcccc agtcacagta ttgctacccc agtaccttct 3600
caggcccttc caccggtccc agccgtggtt ttttcatcag gtttctccca gatctggaaa 3660
gtcagctcag caccccatcc cccagcctgt gtgctgagct ctgtagacca gcgaggggca 3720
tcagggaggg acctgctcag tgcccaccca cccccccttc ccgctgagaa gggtgtagcc 3780
ccgtcataac aaaggtacca tcgtaggctg gctcccagcc cttctctcgg ctcatacact 3840
cgtatgatac tctgacactg ttcttggctc aatgagcatg ctcacacttt aatataagct 3900
atttttctaa ctacaaaggt ttaaatgaac aagagaggcg ttctcatcgg aaatttagca 3960
tcgtagtgct ttgagagagg aaaggactcc ttaaaagaga aaaaaaaaag ctgagattta 4020
ttaaagaaaa aaatgtattt tatgttatat ataaatatat tattacttgt aaatataaag 4080
acgttttata agcatcatta tttatgtatt gtgcaatgtg tataaacgag aataaagaaa 4140
agatgcactt tgctttaata taaacgcaaa taacatgcca aattaaaaaa aaaaaagata 4200
aacacaagat tggtgttttt ttctatgggt gttatcacct agctgaatgt ttttctaaag 4260
gagtttatgt tccattaaac aatttttaaa atgtataaaa aaaaaaaaaa a          4311

<210> 11
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 11
cttcggctgc cccacccg                                               18

<210> 12
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 12
atcgtttggt cctgaacat                                              19

<210> 13
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 13
ccctcctcct cgtcctcg                                               18

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 14
gtcgcccctt ctccccgcag                                             20

<210> 15
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 15
gccgtccgtc gccccttc                                               18

<210> 16
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 16
agcaccgagt gcgtgagc                                               18

<210> 17
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 17
agttcacaga gtcgacta                                               18

<210> 18
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 18
ggcaaaagcc attcccct                                               18

<210> 19
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 19
gccgatcttg ctccgcac                                               18

<210> 20
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 20
ctccggctgc cccacccc                                               18

<210> 21
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 21
cgaacatgac ctccgcac                                               18

<210> 22
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 22
atcgtttggt cctgaacat                                              19

<210> 23
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 23
ccctcctcct cgtcctcg                                               18

<210> 24
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 24
gctgtccgtc gccccttc                                               18

<210> 25
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 25
agcaccgagt gcgtgagc                                               18

<210> 26
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 26
agttcgcaga gtcggcta                                               18

<210> 27
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 27
ggcaaaagcc attcccct                                               18

<210> 28
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 28
gccgattttg ctccgcac                                               18

<210> 29
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 29
ctgccccttc ttccaaaa                                               18

<210> 30
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 30
actcacacac actcctga                                               18

<210> 31
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 31
tgcccaggta ctgcctct                                               18

<210> 32
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 32
gagatccagg agcagatg                                               18

<210> 33
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 33
cttcggctgc cccacccg                                               18

<210> 34
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 34
atcgtttggt cctgaacat                                              19

<210> 35
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 35
ccctcctcct cgtcctcg                                               18

<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 36
gtcgcccctt ctccccgcag                                             20

<210> 37
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 37
gccgtccgtc gccccttc                                               18

<210> 38
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 38
agcaccgagt gcgtgagc                                               18

<210> 39
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 39
agttcacaga gtcgacta                                               18

<210> 40
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 40
ggcaaaagcc attcccct                                               18

<210> 41
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 41
gccgatcttg ctcctcac                                               18

<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 42
gtcgcccctt ctcccccgca g                                           21

<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 43
gtcgcaccgt ctcacagcag                                             20

<210> 44
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 44
atggacaata tgtct                                                  15

<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 45
ctgcggggag aaggggcgac                                             20

<210> 46
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 46
guucaggacc aaacgaucug c                                           21

<210> 47
<211> 23
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 47
gcagaucguu ugguccugaa cau                                         23

<210> 48
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 48
cucacgcacu cggugcucaa g                                           21

<210> 49
<211> 23
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 49
cuugagcacc gagugcguga gcg                                         23

<210> 50
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 50
cucggcgccc gacuucuucu u                                           21

<210> 51
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 51
gaagaagucg ggcgccgagu u                                           21

<210> 52
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 52
acgacuuuuc uccucgccuu u                                           21

<210> 53
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 53
aggcgaggag aaaagucguu u                                           21

<210> 54
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 54
acgaucugcg cucguccggu u                                           21

<210> 55
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 55
ccggacgagc gcagaucguu u                                           21

<210> 56
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 56
ggcgcucacg cacucggugu u                                           21

<210> 57
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 57
caccgagugc gugagcgccu u                                           21

<210> 58
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 58
ggagcggcag cuggagcugu u                                           21

<210> 59
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 59
cagcuccagc ugccgcuccu u                                           21

<210> 60
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 60
aguguucagg uggccggauu u                                           21

<210> 61
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 61
auccggccac cugaacacuu u                                           21

<210> 62
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 62
gucaagaggc uguguugcuu u                                           21

<210> 63
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 63
agcaacacag ccucuugacu u                                           21

<210> 64
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 64
gaggcugugu ugcugugaau u                                           21

<210> 65
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 65
uucacagaca cacagccucu u                                           21

<210> 66
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 66
ucuuacggga agaucaaccu u                                           21

<210> 67
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 67
gguugaucuu cccguaagau u                                           21

<210> 68
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 68
gaucaacccc gagcuggugu u                                           21

<210> 69
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 69
caccagcucg ggguugaucu u                                           21

<210> 70
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 70
ccccgagcug gugugcugcu u                                           21

<210> 71
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 71
gcagcacacc agcucggggu u                                           21

<210> 72
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 72
cgaauuaucu ggccccuggu u                                           21

<210> 73
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 73
ccaggggcca gauaauucgu u                                           21

<210> 74
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 74
cuucuucugg agccuggggu u                                           21

<210> 75
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 75
ccccaggcuc cagaagaagu u                                           21

<210> 76
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 76
uggcuuuugc cucggacagu u                                           21

<210> 77
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 77
cuguccgagg caaaagccau u                                           21

<210> 78
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 78
uucggacaac aagagucagu u                                           21

<210> 79
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 79
cugacucuug uuguccgaau u                                           21

<210> 80
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 80
ccgcagcagu uaccccaucu u                                           21

<210> 81
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 81
gaugggguaa cugcugcggu u                                           21

<210> 82
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 82
guccgccaca cuggacaacu u                                           21

<210> 83
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 83
guuguccagu guggcggacu u                                           21

<210> 84
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 84
cccggacucc aggacgcugu u                                           21

<210> 85
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 85
cagcguccug gaguccgggu u                                           21

<210> 86
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 86
atgttcagga ccaaacgatc tgcg                                        24

<210> 87
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 87
agctgccgct ccttcagttt ctt                                         23

<210> 88
<211> 1282
<212> DNA
<213> Homo sapiens 

<220> 
<223> human SMAD7 mRNA (GenBank XM_033746)

<400> 88
atgttcagga ccaaacgatc tgcgctcgtc cggcgtctct ggaggagccg tgcgcccggc 60
ggcgaggacg aggaggaggg cgcaggggga ggtggaggag gaggcgagct gcggggagaa 120
ggggcgacgg acagccgagc gcatggggcc ggtggcggcg gcccgggcag ggctggatgc 180
tgcctgggca aggcggtgcg aggtgccaaa ggtcaccacc atccccaccc gccagccgcg 240
ggcgccggcg cggccggggg cgccgaggcg gatctgaagg cgctcacgca ctcggtgctc 300
aagaaactga aggagcggca gctggagctg ctgctccagg ccgtggagtc ccgcggcggg 360
acgcgcaccg cgtgcctcct gctgcccggc cgcctggact gcaggctggg cccgggggcg 420
cccgccggcg cgcagcctgc gcagccgccc tcgtcctact cgctccccct cctgctgtgc 480
aaagtgttca ggtggccgga tctcaggcat tcctcggaag tcaagaggct gtgttgctgt 540
gaatcttacg ggaagatcaa ccccgagctg gtgtgctgca acccccatca ccttagccga 600
ctctgcgaac tagagtctcc cccccctcct tactccagat acccgatgga ttttctcaaa 660
ccaactgcag actgtccaga tgctgtgcct tcctccgctg aaacaggggg aacgaattat 720
ctggcccctg gggggctttc aggattccca acttcttctg gagcctgggg atcggtcaca 780
ctggtgcgtg gtggcatact gggaggagaa gacgagagtg gggaggctct actgtgtcca 840
ggagccctct ctggatatct tctatgatct acctcagggg aatggctttt gcctcggaca 900
gctcaattcg gacaacaaga gtcagctggt gcagaaggtg cggagcaaaa tcggctgcgg 960
catccagctg acgcgggagg tggatggtgt gtgggtgtac aaccgcagca gttaccccat 1020
cttcatcaag tccgccacac tggacaaccc ggactccagg acgctgttgg tacacaaggt 1080
gttccccggt ttctccatca aggctttcga ctacgagaag gcgtacagcc tgcagcggcc 1140
caatgaccac gagtttatgc agcagccgtg gacgggcttt accgtgcaga tcagctttgt 1200
gaagggctgg ggccagtgct acacccgcca gttcatcagc agctgcccgt gctggctaga 1260
ggtcatcttc aacagccggt ag                                          1282

<210> 89
<211> 3087
<212> DNA
<213> Homo sapiens

<220> 
<223> human SMAD7 mRNA (GenBank XM_008803)

<400> 89
cggagagccg cgcagggcgc gggccgcgcg gggtggggca gccggagcgc aggcccccga 60
tccccggcgg gcgcccccgg gcccccgcgc gcgccccggc ctccgggaga ctggcgcatg 120
ccacggagcg cccctcgggc cgccgccgct cctgcccggg cccctgctgc tgctgctgtc 180
gcctgcgcct gctgccccaa ctcggcgccc gacttcttca tggtgtgcgg aggtcatgtt 240
cgctccttag caggcaaacg acttttctcc tcgcctcctc gccccgcatg ttcaggacca 300
aacgatctgc gctcgtccgg cgtctctgga ggagccgtgc gcccggcggc gaggacgagg 360
aggagggcgc agggggaggt ggaggaggag gcgagctgcg gggagaaggg gcgacggaca 420
gccgagcgca tggggccggt ggcggcggcc cgggcagggc tggatgctgc ctgggcaagg 480
cggtgcgagg tgccaaaggt caccaccatc cccacccgcc agccgcgggc gccggcgcgg 540
ccgggggcgc cgaggcggat ctgaaggcgc tcacgcactc ggtgctcaag aaactgaagg 600
agcggcagct ggagctgctg ctccaggccg tggagtcccg cggcgggacg cgcaccgcgt 660
gcctcctgct gcccggccgc ctggactgca ggctgggccc gggggcgccc gccggcgcgc 720
agcctgcgca gccgccctcg tcctactcgc tccccctcct gctgtgcaaa gtgttcaggt 780
ggccggatct caggcattcc tcggaagtca agaggctgtg ttgctgtgaa tcttacggga 840
agatcaaccc cgagctggtg tgctgcaacc cccatcacct tagccgactc tgcgaactag 900
agtctccccc ccctccttac tccagatacc cgatggattt tctcaaacca actgcagact 960
gtccagatgc tgtgccttcc tccgctgaaa cagggggaac gaattatctg gcccctgggg 1020
ggctttcagg attcccaact tcttctggag cctggggatc ggtcacactg gtgcgtggtg 1080
gcatactggg aggagaagac gagagtgggg aggctctact gtgtccagga gccctctctg 1140
gatatcttct atgatctacc tcaggggaat ggcttttgcc tcggacagct caattcggac 1200
aacaagagtc agctggtgca gaaggtgcgg agcaaaatcg gctgcggcat ccagctgacg 1260
cgggaggtgg atggtgtgtg ggtgtacaac cgcagcagtt accccatctt catcaagtcc 1320
gccacactgg acaacccgga ctccaggacg ctgttggtac acaaggtgtt ccccggtttc 1380
tccatcaagg ctttcgacta cgagaaggcg tacagcctgc agcggcccaa tgaccacgag 1440
tttatgcagc agccgtggac gggctttacc gtgcagatca gctttgtgaa gggctggggc 1500
cagtgctaca cccgccagtt catcagcagc tgcccgtgct ggctagaggt catcttcaac 1560
agccggtagc cgcgtgcgga ggggacagag cgtgagctga gcaggccaca cttcaaacta 1620
ctttgctgct aatattttcc tcctgagtgc ttgcttttca tgcaaactct ttggtcgttt 1680
tttttttgtt tgttggttgg ttttcttctt ctcgtcctcg tttgtgttct gttttgtttc 1740
gctctttgag aaatagctta tgaaaagaat tgttgggggt ttttttggaa gaaggggcag 1800
gtatgatcgg caggacaccc tgataggaag aggggaagca gaaatccaag caccaccaaa 1860
cacagtgtat gaaggggggc ggtcatcatt tcacttgtca ggagtgtgtg tgagtgtgag 1920
tgtgcggctg tgtgtgcacg cgtgtgcagg agcggcagat ggggagacaa cgtgctcttt 1980
gttttgtgtc tcttatggat gtccccagca gagaggtttg cagtcccaag cggtgtctct 2040
cctgcccctt ggacacgctc agtggggcag aggcagtacc tgggcaagct ggcggctggg 2100
gtcccagcag ctgccaggag cacggctctg tccccagcct gggaaagccc ctgcccctcc 2160
tctccctcat caaggacacg ggcctgtcca caggcttctg agcagcgagc ctgctagtgg 2220
ccgaaccaga accaattatt ttcatccttg tcttattccc ttcctgccag cccctgccat 2280
tgtagcgtct ttcttttttg gccatctgct cctggatctc cctgagatgg gcttcccaag 2340
ggctgccggg gcagccccct cacagtattg ctcacccagt gccctctccc ctcagcctct 2400
cccctgcctg ccctggtgac atcaggtttt tcccggactt agaaaaccag ctcagcactg 2460
cctgctccca gcctgtgtgt taagctctgc tattaggcca gcaagcgggg atgtccctgg 2520
gagggacatg cttagcagtc cccttccctc caagaaggat ttggtccgtc ataacccaag 2580
gtaccatcct aggctgacac ctaactcttc tttcatttct tctacaactc atacactcgt 2640
atgatacttc gacactgttc ttagctcaat gagcatgttt agactttaac ataagctatt 2700
tttctaacta caaaggttta aatgaacaag agaagcattc tcattggaaa tttagcattg 2760
tagtgctttg agagagaaag gactcctgaa aaaaaacctg agatttatta aagaaaaaaa 2820
tgtattttat gttatatata aatatattat tacttgtaaa tataaagacg ttttataagc 2880
atcattattt atgtattgtg caatgtgtat aaacaagaaa aataaagaaa agatgcactt 2940
tgctttaata taaatgcaaa taacaaatgc caaattaaaa aagataaaca caagattggt 3000
gtttttttct atgggtgtta tcacctagct gaatgttttt ctaaaggagt ttatgttcca 3060
ttaaacgatt tttaaaatgt acacttg                                     3087

<210> 90
<211> 1281
<212> DNA
<213> Homo sapiens

<220> 
<223> human SMAD7 mRNA (GenBank AF015261)

<400> 90
atgttcagga ccaaacgatc tgcgctcgtc cggcgtctct ggaggagccg tgcgcccggc 60
ggcgaggacg aggaggaggg cgcaggggga ggtggaggag gaggcgagct gcggggagaa 120
ggggcgacgg acagccgagc gcatggggcc ggtggcggcg gcccgggcag ggctggatgc 180
tgcctgggca aggcggtgcg aggtgccaaa tgtcaccacc atccccaccc gccagccgcg 240
ggcgccggcg cggccggggg cgccgaggcg gatctgaagg cgctcacgca ctcggtgctc 300
aagaaactga aggagcggca gctggagctg ctgctccagg ccgtggagtc ccgcggcggg 360
acgcgcaccg cgtgcctcct gctgcccggc cgcctggact gcaggctggg cccgggggcg 420
cccgccggcg cgcagcctgc gcagccgccc tcgtcctact cgctccccct cctgctgtgc 480
aaagtgttca ggtggccgga tctcaggcat tcctcggaag tcaagaggct gtgttgctgt 540
gaatcttacg ggaagatcaa ccccgagctg gtgtgctgca acccccatca ccttagccga 600
ctctgcgaac tagagtctcc cccccctcct tactccagat acccgatgga ttttctcaaa 660
ccaactgcag actgtccaga tgctgtgcct tcctccgctg aaacaggggg aacgaattat 720
ctggcccctg gggggctttc agattcccaa cttcttctgg agcctgggga tcggtcacac 780
tggtgcgtgg tggcatactg ggaggagaag acgagagtgg ggaggctcta ctgtgtccag 840
gagccctctc tggatatctt ctatgatcta cctcagggga atggcttttg cctcggacag 900
ctcaattcgg acaacaagag tcagctggtg cagaaggtgc ggagcaaaat cggctgcggc 960
atccagctga cgcgggaggt ggatggtgtg tgggtgtaca accgcagcag ttaccccatc 1020
ttcatcaagt ccgccacact ggacaacccg gactccagga cgctgttggt acacaaggtg 1080
ttccccggtt tctccatcaa ggctttcgac tacgagaagg cgtacagcct gcagcggccc 1140
aatgaccacg agtttatgca gcagccgtgg acgggcttta ccgtgcagat cagctttgtg 1200
aagggctggg gccagtgcta cacccgccag ttcatcagca gctgcccgtg ctggctagag 1260
gtcatcttca acagccggta g                                           1281

<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = cytosine, 5-methylcytosine, or 2-O-methylcytosine

<220> 
<221> misc_feature   
<222> 4, 17
<223> n = guanine, 5-methylguanine, or 2-O-methylguanine


<400> 91
gtnncccctt ctcccnncag                                             20

<210> 92
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = 5-methyl 2'-deoxycytidine 5'-monophosphate

<400> 92
gtngcccctt ctcccngcag                                             20

<210> 93
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 1, 20
<223> n = 2'-deoxyguanosine methylphosphonate

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = 5-methyl-2'-deoxycytidine-5'-monophosphate

<400> 93
ntngcccctt ctcccngcan                                             20

<210> 94
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 94
gtttggtcct gaacatgc                                               18

<210> 95
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 95
gtttggtcct gaacat                                                 16

<210> 96
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 96
gtttggtcct gaacatg                                                17

<210> 97
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 97
agcaccgagt gcgtgagc                                               18

<210> 98
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 1, 18
<223> n = 2'-deoxyadenosine methylphosphonate

<220> 
<221> misc_feature   
<222> 6, 12
<223> n = 5-methyl-2'-deoxycytidine-5'-monophosphate

<400> 98
ngcacngagt gngtgagn                                               18

<210> 99
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 99
cgaacatgac ctccgcac                                               18

<210> 100
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 1, 14
<223> n = 5-methyl-2'-deoxycytidine-5'-monophosphate

<400> 100
ngaacatgac ctcngcac                                               18

<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = 5-methyl-2'-deoxycytidine-5'-monophosphate

<400> 101
gtngcccctt ctcccngcag                                             20

<210> 102
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 102
gatcgtttgg tcctgaa                                                17

<210> 103
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 103
atcgtttggt cctgaac                                                17

<210> 104
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 1, 20
<223> n = 2'-deoxyadenosine methylphosphonate

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = 5-methyl-2'-deoxycytidine-5'-monophosphate

<400> 104
ntngcccctt ctcccngcan c                                           21

<210> 105
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = 5-methyl-2'-deoxycytidine-5'-monophosphate

<400> 105
gtngcccctt ctcccngcag c                                           21

<210> 106
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified SMAD7 ODN

<220> 
<221> misc_feature   
<222> 3, 16
<223> n = chemically modified nucleoside

<400> 106
gtngcccctt ctcccngcag                                             20

<210> 107
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 107
tccgtcatcg ctcctcaggg                                             20

<210> 108
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 108
atgcattctg cccccaagga                                             20

<210> 109
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 109
tgtgaatctt acgggaagat caac                                        24

<210> 110
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 110
agttcgcaga gtcggctaag g                                           21

<210> 111
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 111
ccgagctggt gtgctgcaac cc                                          22

<210> 112
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 112
gaaggtgaag gtcggagtc                                              19

<210> 113
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 113
gaagatggtg atgggatttc                                             20

<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 114
caagcttccc gttctcagcc                                             20

<210> 115
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 115
cgacagcagc agcagcag                                               18

<210> 116
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 116
aggaggcgag gagaaaag                                               18

<210> 117
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 117
gctgtccgtc gccccttc                                               18

<210> 118
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 118
aggcggccgg gcagcagg                                               18

<210> 119
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 119
agcctcttga cttccgag                                               18

<210> 120
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 120
agtctgcagt tggtttga                                               18

<210> 121
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 121
agaagttggg aatctgaa                                               18

<210> 122
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 122
gtatgccacc acgcacca                                               18

<210> 123
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 123
tggacacagt agagcctc                                               18

<210> 124
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 124
gccgattttg ctccgcac                                               18

<210> 125
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 125
ggacttgatg aagatggg                                               18

<210> 126
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 126
accttgtgta ccaacagc                                               18

<210> 127
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 127
ctgatctgca cggtaaag                                               18

<210> 128
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 128
ggcagctgct gatgaact                                               18

<210> 129
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 129
gctcagctca cgctctgt                                               18

<210> 130
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 130
tgcatgaaaa gcaagcac                                               18

<210> 131
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 131
aaaacagaac acaaacga                                               18

<210> 132
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 132
tgcttggatt tctgcttc                                               18

<210> 133
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 133
gttgtctccc catctgcc                                               18

<210> 134
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 134
ttgggactgc aaacctct                                               18

<210> 135
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 135
aattggttct ggttcggc                                               18

<210> 136
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 136
aaaacctgat gtcaccag                                               18

<210> 137
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 137
acacacagga tgggagca                                               18

<210> 138
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 138
ggacatcccc gcttgctg                                               18

<210> 139
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 139
gatggtacct tgggttat                                               18

<210> 140
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 140
gtagaagaaa tgaaagaa                                               18

<210> 141
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 141
aacctttgta gttagaaa                                               18

<210> 142
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 142
atttccaatg agaatgct                                               18

<210> 143
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 143
caatcttgtg tttatctt                                               18

<210> 144
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 144
attcagctag gtgataac                                               18

<210> 145
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 145
ggaacagttc gtccatggc                                              19

<210> 146
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 146
ggaacagtta gtccatggc                                              19

<210> 147
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 147
ctgccacgtt ctcctgcacc                                             20

<210> 148
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 148
ctgccaagtt cacctgcacc                                             20

<210> 149
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 149
gtcgcccctt ctccccgcag c                                           21

<210> 150
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 150
gtagccccat cacccagcag c                                           21

<210> 151
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 151
gtcgctcttc tcctccgcca g                                           21

<210> 152
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 152
tcgtcgtttt gtcgttttgt cgtt                                        24

<210> 153
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 153
tgctgctttt gtgcttttgt gctt                                        24

<210> 154
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 154
gggggacgat cgtcgggggg                                             20

<210> 155
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 155
tccatgacgt tcctgacgtt                                             20

<210> 156
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 156
tccatgagct tcctgagctt                                             20

<210> 157
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 157
tgctgctttt gtgcttttgt gctt                                        24

<210> 158
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SMAD7 ODN

<400> 158
gggggacgat cgtcgggggg                                             20
