                         SEQUENCE LISTING



<110>  MAZUR, Daniel

       VANDER HORN, Peter B.

       TOZER, Eileen

       CHEN, Sihong

       LUO, Guobin

       SHIRLEY, Joshua

       HEINEMANN, Kevin

 

<120>  POLYMERASE COMPOSITIONS AND KITS, AND METHODS OF USING AND MAKING

        THE SAME



<130>  LT01102 PCT

<150> 62/235,616
<151> 2015-10-01



<160>  122



<170>  PatentIn version 3.5



<210>  1

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic: large fragment of wild type Bst DNA polymerase



<400>  1



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu His Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu His Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Asp Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Glu Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Asn Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr His Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  2

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic: large fragment Bst DNA polymerase



<400>  2



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu His Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Asp Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Asn Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  3

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  3



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu His Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Asp Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu Arg Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Asn Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala Ala 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  4

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  4



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





Arg Glu Ile Val Glu Asn Ile Leu Ala Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Asp Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu Arg Arg Arg Arg Phe Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Asn Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala Ala 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  5

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic





<220>

<221>  misc_feature

<222>  (2)..(2)

<223>  Xaa can be any naturally occurring amino acid



<220>

<221>  misc_feature

<222>  (4)..(5)

<223>  Xaa can be any naturally occurring amino acid



<400>  5



Asp Xaa Ser Xaa Xaa Glu 

1               5       





<210>  6

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic





<220>

<221>  misc_feature

<222>  (2)..(7)

<223>  Xaa can be any naturally occurring amino acid



<400>  6



Lys Xaa Xaa Xaa Xaa Xaa Xaa Tyr Gly 

1               5                   





<210>  7

<211>  4

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic



<400>  7



Val His Asp Glu 

1               





<210>  8

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic





<220>

<221>  misc_feature

<222>  (2)..(3)

<223>  Xaa can be any naturally occurring amino acid



<400>  8



Asp Xaa Xaa Ser Leu Tyr Pro Ser 

1               5               





<210>  9

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic





<220>

<221>  misc_feature

<222>  (2)..(4)

<223>  Xaa can be any naturally occurring amino acid



<220>

<221>  misc_feature

<222>  (7)..(7)

<223>  Xaa can be any naturally occurring amino acid



<400>  9



Lys Xaa Xaa Xaa Asn Ser Xaa Tyr Gly 

1               5                   





<210>  10

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic



<400>  10



Tyr Gly Asp Thr Asp Ser 

1               5       





<210>  11

<211>  6

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic





<220>

<221>  misc_feature

<222>  (2)..(5)

<223>  Xaa can be any naturally occurring amino acid



<220>

<221>  misc_feature

<222>  (6)..(6)

<223>  Xaa is Phe or Tyr



<400>  11



Asp Xaa Xaa Xaa Xaa Xaa 

1               5       





<210>  12

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic





<220>

<221>  misc_feature

<222>  (2)..(2)

<223>  Xaa can be any naturally occurring amino acid



<220>

<221>  misc_feature

<222>  (4)..(6)

<223>  Xaa can be any naturally occurring amino acid



<220>

<221>  misc_feature

<222>  (7)..(7)

<223>  Xaa is Ser or Ala



<400>  12



Phe Xaa Gly Xaa Xaa Xaa Xaa 

1               5           





<210>  13

<211>  4

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic





<220>

<221>  misc_feature

<222>  (2)..(2)

<223>  Xaa can be any naturally occurring amino acid



<400>  13



Tyr Xaa Asp Asp 

1               





<210>  14

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic





<220>

<221>  misc_feature

<222>  (2)..(8)

<223>  Xaa can be any naturally occurring amino acid



<400>  14



Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys 

1               5                   





<210>  15

<211>  832

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  15



Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 

1               5                   10                  15      





Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 

            20                  25                  30          





Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 

        35                  40                  45              





Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 

    50                  55                  60                  





Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 

65                  70                  75                  80  





Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 

                85                  90                  95      





Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 

            100                 105                 110         





Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 

        115                 120                 125             





Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 

    130                 135                 140                 





Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 

145                 150                 155                 160 





Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 

                165                 170                 175     





Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 

            180                 185                 190         





Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 

        195                 200                 205             





Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 

    210                 215                 220                 





Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 

225                 230                 235                 240 





Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 

                245                 250                 255     





Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 

            260                 265                 270         





Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 

        275                 280                 285             





Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 

    290                 295                 300                 





Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 

305                 310                 315                 320 





Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 

                325                 330                 335     





Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 

            340                 345                 350         





Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 

        355                 360                 365             





Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 

    370                 375                 380                 





Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 

385                 390                 395                 400 





Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 

                405                 410                 415     





Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 

            420                 425                 430         





Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 

        435                 440                 445             





Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 

    450                 455                 460                 





Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 

465                 470                 475                 480 





Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 

                485                 490                 495     





Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg 

            500                 505                 510         





Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 

        515                 520                 525             





Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 

    530                 535                 540                 





Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 

545                 550                 555                 560 





His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 

                565                 570                 575     





Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 

            580                 585                 590         





Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 

        595                 600                 605             





Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 

    610                 615                 620                 





Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 

625                 630                 635                 640 





Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 

                645                 650                 655     





Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 

            660                 665                 670         





Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 

        675                 680                 685             





Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 

    690                 695                 700                 





Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 

705                 710                 715                 720 





Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 

                725                 730                 735     





Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 

            740                 745                 750         





Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 

        755                 760                 765             





Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 

    770                 775                 780                 





Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 

785                 790                 795                 800 





Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 

                805                 810                 815     





Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 

            820                 825                 830         





<210>  16

<211>  876

<212>  PRT

<213>  Organism: Bacillus stearothermophilus



<220>

<223>  Synthetic:wild type Bst DNA polymerase



<400>  16



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu His 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  17

<211>  1746

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  17

atggcaaaaa tggcatttac cctggcagat cgtgttaccg aagaaatgct ggcagataaa       60



gcagcactgg ttgttgaagt tgtggaagaa aactatcatg atgcaccgat tgttggtatt      120



gccgttgtta atgaacgcgg tcgttttttt ctgcgtccgg aaaccgcact ggcagatccg      180



cagtttgttg catggctggg tgatgaaacc aaaaagaaaa gcatgttcga cagcaaacgt      240



gcagcagttg cactgaaatg gaaaggtatt gaactgtgcg gtgtgtcatt tgatctgctg      300



ctggcagcat atctgctgga tccggcacag ggtgttgatg atgttgcagc agcagcaaaa      360



atgaaacagt atgaagcagt tcgtccggat gaagcagttt atggtaaagg tgcaaaacgt      420



gcagttccgg atgaaccggt tctggcagaa catctggttc gtaaagcagc agcaatttgg      480



gaactggaac gtccgtttct ggatgaactg cgtcgtaatg aacaggatcg tctgctggtt      540



gaactggaac agccgctgag cagcattctg gcagaaatgg aatttgccgg tgttaaagtt      600



gataccaaac gtctggaaca aatgggtaaa gaactggccg aacaactggg caccgttgaa      660



cagcgtattt atgaactggc aggccaagaa tttaacatta atagcccgaa acagctgggc      720



gttatcctgt ttgaaaaact gcagctgccg gttctgaaaa aaaccaaaac cggttatagc      780



accagcgcag atgttctgga aaaactggca ccgtatcatg aaattgtgga aaacattctg      840



cactatcgtc agctgggtaa actgcagagc acctatattg aaggtctgct gaaagttgtg      900



cgtccggata ccaaaaaagt gcataccatt tttaaccagg cactgaccca gaccggtcgt      960



ctgagcagca ccgaaccgaa tctgcagaat attccgattc gtctggaaga aggtcgtaaa     1020



attcgtcagg catttgttcc gagcgaaagc gattggctga tttttgcagc agattatagc     1080



cagattgaac tgcgtgttct ggcacatatt gccgaagatg ataatctgat ggaagcattt     1140



cgtcgcgatc tggatattca taccaaaacc gccatggata tttttcaggt tagcgaagat     1200



gaagtgaccc cgaatatgcg tcgtcaggca aaagcagtta attttggtat tgtgtatggc     1260



atcagcgatt atggtctggc acagaatctg aatattagcc gtaaagaagc agccgaattt     1320



atcgaacgtt actttcagag ctttccgggt gttaaacgct atatggaaaa cattgtccaa     1380



gaagccaaac agaaaggtta tgttaccacc ctgctgcatc gtcgtcgtta tctgccgcgt     1440



attaccagcc gtaactttaa tgttcgtagc tttgcagaac gcatggcaat gaataccccg     1500



attcagggta gcgcagcaga tattatcaaa aaagccatga tcgatctgaa cgcacgtctg     1560



aaagaagaac gtctgcaggc acatttactg ctgcaggttc atgatgaact gattctggaa     1620



gcaccgaaag aagaaatgga acgtctttgt cgtctggttc cggaagttat ggaacaggca     1680



gttaccctgc gtgttccgct gaaagttgat tatcgttatg gtagcacctg gtatgatgcc     1740



aaataa                                                                1746





<210>  18

<211>  606

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  18



Met Val Ile Ser Tyr Asp Asn Tyr Val Thr Ile Leu Asp Glu Glu Thr 

1               5                   10                  15      





Leu Lys Ala Trp Ile Ala Lys Leu Glu Lys Ala Pro Val Phe Ala Phe 

            20                  25                  30          





Asp Thr Glu Thr Asp Ser Leu Asp Asn Ile Ser Ala Asn Leu Val Gly 

        35                  40                  45              





Leu Ser Phe Ala Ile Glu Pro Gly Val Ala Ala Tyr Ile Pro Val Ala 

    50                  55                  60                  





His Asp Tyr Leu Asp Ala Pro Asp Gln Ile Ser Arg Glu Arg Ala Leu 

65                  70                  75                  80  





Glu Leu Leu Lys Pro Leu Leu Glu Asp Glu Lys Ala Leu Lys Val Gly 

                85                  90                  95      





Gln Asn Leu Lys Tyr Asp Arg Gly Ile Leu Ala Asn Tyr Gly Ile Glu 

            100                 105                 110         





Leu Arg Gly Ile Ala Phe Asp Thr Met Leu Glu Ser Tyr Ile Leu Asn 

        115                 120                 125             





Ser Val Ala Gly Arg His Asp Met Asp Ser Leu Ala Glu Arg Trp Leu 

    130                 135                 140                 





Lys His Lys Thr Ile Thr Phe Glu Glu Ile Ala Gly Lys Gly Lys Asn 

145                 150                 155                 160 





Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu Glu Ala Gly Arg Tyr Ala 

                165                 170                 175     





Ala Glu Asp Ala Asp Val Thr Leu Gln Leu His Leu Lys Met Trp Pro 

            180                 185                 190         





Asp Leu Gln Lys His Lys Gly Pro Leu Asn Val Phe Glu Asn Ile Glu 

        195                 200                 205             





Met Pro Leu Val Pro Val Leu Ser Arg Ile Glu Arg Asn Gly Val Lys 

    210                 215                 220                 





Ile Asp Pro Lys Val Leu His Asn His Ser Glu Glu Leu Thr Leu Arg 

225                 230                 235                 240 





Leu Ala Glu Leu Glu Lys Lys Ala His Glu Ile Ala Gly Glu Glu Phe 

                245                 250                 255     





Asn Leu Ser Ser Thr Lys Gln Leu Gln Thr Ile Leu Phe Glu Lys Gln 

            260                 265                 270         





Gly Ile Lys Pro Leu Lys Lys Thr Pro Gly Gly Ala Pro Ser Thr Ser 

        275                 280                 285             





Glu Glu Val Leu Glu Glu Leu Ala Leu Asp Tyr Pro Leu Pro Lys Val 

    290                 295                 300                 





Ile Leu Glu Tyr Arg Gly Leu Ala Lys Leu Lys Ser Thr Tyr Thr Asp 

305                 310                 315                 320 





Lys Leu Pro Leu Met Ile Asn Pro Lys Thr Gly Arg Val His Thr Ser 

                325                 330                 335     





Tyr His Gln Ala Val Thr Ala Thr Gly Arg Leu Ser Ser Thr Asp Pro 

            340                 345                 350         





Asn Leu Gln Asn Ile Pro Val Arg Asn Glu Glu Gly Arg Arg Ile Arg 

        355                 360                 365             





Gln Ala Phe Ile Ala Pro Glu Asp Tyr Val Ile Val Ser Ala Asp Tyr 

    370                 375                 380                 





Ser Gln Ile Glu Leu Arg Ile Met Ala His Leu Ser Arg Asp Lys Gly 

385                 390                 395                 400 





Leu Leu Thr Ala Phe Ala Glu Gly Lys Asp Ile His Arg Ala Thr Ala 

                405                 410                 415     





Ala Glu Val Phe Gly Leu Pro Leu Glu Thr Val Thr Ser Glu Gln Arg 

            420                 425                 430         





Arg Ser Ala Lys Ala Ile Asn Phe Gly Leu Ile Tyr Gly Met Ser Ala 

        435                 440                 445             





Phe Gly Leu Ala Arg Gln Leu Asn Ile Pro Arg Lys Glu Ala Gln Lys 

    450                 455                 460                 





Tyr Met Asp Leu Tyr Phe Glu Arg Tyr Pro Gly Val Leu Glu Tyr Met 

465                 470                 475                 480 





Glu Arg Thr Arg Ala Gln Ala Lys Glu Gln Gly Tyr Val Glu Thr Leu 

                485                 490                 495     





Asp Gly Arg Arg Leu Tyr Leu Pro Asp Ile Lys Ser Ser Asn Gly Ala 

            500                 505                 510         





Arg Arg Ala Ala Ala Glu Arg Ala Ala Ile Asn Ala Pro Met Gln Gly 

        515                 520                 525             





Thr Ala Ala Asp Ile Ile Lys Arg Ala Met Ile Ala Val Asp Ala Trp 

    530                 535                 540                 





Leu Gln Ala Glu Gln Pro Arg Val Arg Met Ile Met Gln Val His Asp 

545                 550                 555                 560 





Glu Leu Val Phe Glu Val His Lys Asp Asp Val Asp Ala Val Ala Lys 

                565                 570                 575     





Gln Ile His Gln Leu Met Glu Asn Cys Thr Arg Leu Asp Val Pro Leu 

            580                 585                 590         





Leu Val Glu Val Gly Ser Gly Glu Asn Trp Asp Gln Ala His 

        595                 600                 605     





<210>  19

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  19



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Lys Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Arg Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu His Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Asn Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  20

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  20



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Lys Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Arg Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu His Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu Arg Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Asn Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala Ala 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  21

<211>  36

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic: Oligo 221





<220>

<221>  misc_feature

<222>  (34)..(34)

<223>  n is flourescein-dT



<400>  21

tttttttgca ggtgacaggt ttttcctgtc accngc                                 36





<210>  22

<211>  44

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic: Hairpin oligo



<400>  22

tttttttccc tttcctttcg ggtgacaggt ttttcctgtc accc                        44





<210>  23

<211>  1740

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  23

atggctaaaa tggcttttac tcttgctgat cgtgttactg aagaaatgct tgctgataaa       60



gctgctcttg ttgttgaagt tgttgaagaa aattatcatg atgctcctat tgttggtatt      120



gctgttgtta atgaacgtgg tcgttttttt cttcgtcctg aaactgctct tgctgatcct      180



caatttgttg cttggcttgg tgatgaaact aaaaaaaaat ctatgtttga ttctaaacgt      240



gctgctgttg ctcttaaatg gaaaggtatt gaactttgtg gtgtttcttt tgatcttctt      300



cttgctgctt atcttcttga tcctgctcaa ggtgttgatg atgttgctgc tgctgctaaa      360



atgaaacaat atgaagctgt tcgtcctgat gaagctgttt atggtaaagg tgctaaacgt      420



gctgttcctg atgaacctgt tcttgctgaa catcttgttc gtaaagctgc tgctatttgg      480



gaacttgaac gtccttttct tgatgaactt cgtcgtaatg aacaagatcg tcttcttgtt      540



gaacttgaac aacctctttc ttctattctt gctgaaatgg aatttgctgg tgttaaagtt      600



gatactaaac gtcttgaaca aatgggtaaa gaacttgctg aacaacttgg tactgttaaa      660



caacgtattt atgaacttgc tggtcaagaa tttaatattc gttctcctaa acaacttggt      720



gttattcttt ttgaaaaact tcaacttcct gttcttaaaa aaactaaaac tggttattct      780



acttctgctg atgttcttga aaaacttgct ccttatcatg aaattgttga aaatattctt      840



cattatcgtc aacttggtaa acttcaatct acttatattg aaggtcttct taaagttgtt      900



cgtcctgata ctaaaaaagt tcatactatt tttaatcaag ctcttactca aactggtcgt      960



ctttcttcta ctgaacctaa tcttcaaaat attcctattc gtcttgaaga aggtcgtaaa     1020



attcgtcaag cttttgttcc ttctgaatct gattggctta tttttgctgc tgattattct     1080



caaattgaac ttcgtgttct tgctcatatt gctgaagatg ataatcttat ggaagctttt     1140



cgtcgtgatc ttgatattca tactaaaact gctatggata tttttcaagt ttctgaagat     1200



gaagttactc ctaatatgcg tcgtcaagct aaagctgtta attttggtat tgtttatggt     1260



atttctaaat atggtcttgc tcaaaatctt aatatttctc gtaaagaagc tgctgaattt     1320



attgaacgtt attttcaatc ttttcctggt gttaaacgtt atatggaaaa tattgttcaa     1380



gaagctaaac aaaaaggtta tgttactact cttcttcatc gtcgtcgtta tcttcctgat     1440



attacttctc gtaattttaa tgttcgttct tttgctgaac gtatggctat gaatactcct     1500



attcaaggtt ctgctgctga tattattaaa aaagctatga ttgatcttaa tgctcgtctt     1560



aaagaagaac gtcttcaagc tcatcttctt cttcaagttc atgatgaact tattcttgaa     1620



gctcctaaag aagaaatgga acgtctttgt cgtcttgttc ctgaagttat ggaacaagct     1680



gttactcttc gtgttcctct taaagttgat tatcgttatg gttctacttg gtatgatgct     1740





<210>  24

<211>  832

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  24



Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 

1               5                   10                  15      





Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 

            20                  25                  30          





Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 

        35                  40                  45              





Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 

    50                  55                  60                  





Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 

65                  70                  75                  80  





Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 

                85                  90                  95      





Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 

            100                 105                 110         





Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 

        115                 120                 125             





Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 

    130                 135                 140                 





Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 

145                 150                 155                 160 





Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 

                165                 170                 175     





Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 

            180                 185                 190         





Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 

        195                 200                 205             





Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 

    210                 215                 220                 





Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 

225                 230                 235                 240 





Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 

                245                 250                 255     





Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 

            260                 265                 270         





Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 

        275                 280                 285             





Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 

    290                 295                 300                 





Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 

305                 310                 315                 320 





Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 

                325                 330                 335     





Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 

            340                 345                 350         





Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 

        355                 360                 365             





Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 

    370                 375                 380                 





Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 

385                 390                 395                 400 





Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 

                405                 410                 415     





Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 

            420                 425                 430         





Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 

        435                 440                 445             





Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 

    450                 455                 460                 





Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 

465                 470                 475                 480 





Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 

                485                 490                 495     





Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg 

            500                 505                 510         





Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 

        515                 520                 525             





Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 

    530                 535                 540                 





Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 

545                 550                 555                 560 





His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 

                565                 570                 575     





Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 

            580                 585                 590         





Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 

        595                 600                 605             





Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 

    610                 615                 620                 





Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 

625                 630                 635                 640 





Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 

                645                 650                 655     





Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 

            660                 665                 670         





Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 

        675                 680                 685             





Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 

    690                 695                 700                 





Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 

705                 710                 715                 720 





Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Arg Leu Glu Ala Arg 

                725                 730                 735     





Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 

            740                 745                 750         





Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 

        755                 760                 765             





Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 

    770                 775                 780                 





Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 

785                 790                 795                 800 





Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 

                805                 810                 815     





Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 

            820                 825                 830         





<210>  25

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  25



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu His 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  26

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  26



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu His 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  27

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  27



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr Asn Glu Ile Val Glu Asn Ile Leu His 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  28

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  28



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  29

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  29



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu His 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala Ser Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  30

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  30



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu His 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  31

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  31



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  32

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  32



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Ala Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr Asn Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Arg Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  33

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  33



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu His Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Asn Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  34

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  34



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Ala Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





Asn Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Asp Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Arg Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  35

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  35



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  36

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  36



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu His Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  37

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  37



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Asp Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  38

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  38



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Lys Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  39

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  39



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gln Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  40

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  40



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Lys Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  41

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  41



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Arg Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  42

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  42



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Ile Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  43

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  43



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Arg Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  44

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  44



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val His Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  45

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  45



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Lys Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  46

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  46



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Thr Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  47

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  47



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Lys Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  48

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  48



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Arg Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  49

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  49



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Met Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  50

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  50



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Lys Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  51

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  51



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Arg Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  52

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  52



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Thr Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  53

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  53



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Lys Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  54

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  54



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Arg Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  55

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  55



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Gly Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  56

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  56



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Arg Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  57

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  57



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Arg Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  58

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  58



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Tyr Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  59

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  59



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Cys Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  60

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  60



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Arg Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  61

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  61



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Lys Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  62

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  62



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Leu Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  63

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  63



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Arg Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  64

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  64



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Tyr Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  65

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  65



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Arg Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  66

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  66



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Lys Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  67

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  67



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Cys Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  68

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  68



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Lys Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  69

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  69



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Arg Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  70

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  70



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Arg Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  71

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  71



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  72

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  72



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Lys Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  73

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  73



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Met Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  74

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  74



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala Thr Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  75

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  75



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu Gly 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  76

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  76



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Arg Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  77

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  77



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Arg Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala Thr Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  78

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  78



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu His Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Arg Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Glu Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu Gly 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala Thr Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr His Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     





<210>  79

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  79



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Lys Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  80

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  80



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gln Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  81

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  81



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Lys Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  82

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  82



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Arg Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  83

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  83



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Ile Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  84

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  84



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Arg Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  85

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  85



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val His Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  86

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  86



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Lys Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  87

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  87



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Thr Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  88

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  88



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Lys Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  89

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  89



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Arg Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  90

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  90



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Met Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  91

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  91



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Lys Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  92

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  92



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Arg Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  93

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  93



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Thr Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  94

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  94



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Lys Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  95

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  95



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Arg Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  96

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  96



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Gly Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  97

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  97



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Arg Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  98

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  98



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Arg Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  99

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  99



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Tyr Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  100

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  100



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Cys Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  101

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  101



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Arg Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  102

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  102



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Lys Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  103

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  103



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Leu 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  104

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  104



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Arg 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  105

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  105



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Tyr Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  106

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  106



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Arg Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  107

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  107



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Lys Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  108

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  108



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Cys Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  109

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  109



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Lys Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  110

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  110



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Arg Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  111

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  111



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Arg Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  112

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  112



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Cys Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  113

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  113



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Lys Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  114

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  114



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Met Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  115

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  115



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala Thr 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  116

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  116



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Leu Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu Gly Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  117

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  117



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Arg Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala His 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  118

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  118



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Arg Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu His Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala Thr 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  119

<211>  581

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic polypeptide sequence



<400>  119



Met Ala Lys Met Ala Phe Thr Leu Ala Asp Arg Val Thr Glu Glu Met 

1               5                   10                  15      





Leu Ala Asp Lys Ala Ala Leu Val Val Glu Val Val Glu Glu Asn Tyr 

            20                  25                  30          





His Asp Ala Pro Ile Val Gly Ile Ala Val Val Asn Glu Arg Gly Arg 

        35                  40                  45              





Phe Phe Leu Arg Pro Glu Thr Ala Leu Ala Asp Pro Gln Phe Val Ala 

    50                  55                  60                  





Trp Leu Gly Asp Glu Thr Lys Lys Lys Ser Met Phe Asp Ser Lys Arg 

65                  70                  75                  80  





Ala Ala Val Ala Leu Lys Trp Lys Gly Ile Glu Leu Cys Gly Val Ser 

                85                  90                  95      





Phe Asp Leu Leu Leu Ala Ala Tyr Leu Leu Asp Pro Ala Gln Gly Val 

            100                 105                 110         





Asp Asp Val Ala Ala Ala Ala Lys Met Lys Gln Tyr Glu Ala Val Arg 

        115                 120                 125             





Pro Asp Glu Ala Val Tyr Gly Lys Gly Ala Lys Arg Ala Val Pro Asp 

    130                 135                 140                 





Glu Pro Val Leu Ala Glu His Leu Val Arg Lys Ala Ala Ala Ile Trp 

145                 150                 155                 160 





Glu Leu Glu Arg Pro Phe Leu Asp Glu Leu Arg Arg Asn Glu Gln Asp 

                165                 170                 175     





Arg Leu Leu Val Glu Leu Glu Gln Pro Leu Ser Ser Ile Leu Ala Glu 

            180                 185                 190         





Met Glu Phe Ala Gly Val Lys Val Asp Thr Lys Arg Leu Glu Gln Met 

        195                 200                 205             





Gly Lys Glu Leu Ala Glu Gln Leu Gly Thr Val Glu Gln Arg Ile Tyr 

    210                 215                 220                 





Glu Leu Ala Gly Gln Glu Phe Asn Ile Asn Ser Pro Lys Gln Leu Gly 

225                 230                 235                 240 





Val Ile Leu Phe Glu Lys Leu Gln Leu Pro Val Arg Lys Lys Thr Lys 

                245                 250                 255     





Thr Gly Tyr Ser Thr Ser Ala Asp Val Leu Glu Lys Leu Ala Pro Tyr 

            260                 265                 270         





His Glu Ile Val Glu Asn Ile Leu Met Tyr Arg Gln Leu Gly Lys Leu 

        275                 280                 285             





Gln Ser Thr Tyr Ile Glu Gly Leu Leu Lys Val Val Arg Pro Asp Thr 

    290                 295                 300                 





Lys Lys Val His Thr Ile Phe Asn Gln Ala Leu Thr Gln Thr Gly Arg 

305                 310                 315                 320 





Leu Ser Ser Thr Glu Pro Asn Leu Gln Asn Ile Pro Ile Arg Leu Glu 

                325                 330                 335     





Glu Gly Arg Lys Ile Arg Gln Ala Phe Val Pro Ser Glu Ser Asp Trp 

            340                 345                 350         





Leu Ile Phe Ala Ala Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 

        355                 360                 365             





His Ile Ala Glu Asp Asp Asn Leu Met Glu Ala Phe Arg Arg Asp Leu 

    370                 375                 380                 





Asp Ile His Thr Lys Thr Ala Met Asp Ile Phe Gln Val Ser Glu Asp 

385                 390                 395                 400 





Glu Val Thr Pro Asn Met Arg Arg Gln Ala Lys Ala Val Asn Phe Gly 

                405                 410                 415     





Ile Val Tyr Gly Ile Ser Lys Tyr Gly Leu Ala Gln Asn Leu Asn Ile 

            420                 425                 430         





Ser Arg Lys Glu Ala Ala Glu Phe Ile Glu Arg Tyr Phe Gln Ser Phe 

        435                 440                 445             





Pro Gly Val Lys Arg Tyr Met Glu Asn Ile Val Gln Glu Ala Lys Gln 

    450                 455                 460                 





Lys Gly Tyr Val Thr Thr Leu Leu Gly Arg Arg Arg Tyr Leu Pro Asp 

465                 470                 475                 480 





Ile Thr Ser Arg Asn Phe Arg Val Arg Ser Phe Ala Glu Arg Met Ala 

                485                 490                 495     





Met Asn Thr Pro Ile Gln Gly Ser Ala Ala Asp Ile Ile Lys Lys Ala 

            500                 505                 510         





Met Ile Asp Leu Asn Ala Arg Leu Lys Glu Glu Arg Leu Gln Ala Thr 

        515                 520                 525             





Leu Leu Leu Gln Val His Asp Glu Leu Ile Leu Glu Ala Pro Lys Glu 

    530                 535                 540                 





Glu Met Glu Arg Leu Cys Arg Leu Val Pro Glu Val Met Glu Gln Ala 

545                 550                 555                 560 





Val Thr Leu Arg Val Pro Leu Lys Val Asp Tyr Arg Tyr Gly Ser Thr 

                565                 570                 575     





Trp Tyr Asp Ala Lys 

            580     





<210>  120

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  120



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu Arg Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Gln Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr Arg Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     







<210>  121

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  121



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu Arg Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Arg Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu Met 

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Lys Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Gln Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu Gly 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Arg Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala Thr Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr Arg Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     




<210>  122

<211>  876

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Synthetic:



<400>  122



Met Lys Lys Lys Leu Val Leu Ile Asp Gly Ser Ser Val Ala Tyr Arg 

1               5                   10                  15      





Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 

            20                  25                  30          





Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 

        35                  40                  45              





Glu Glu Pro Thr His Met Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 

    50                  55                  60                  





Phe Arg His Glu Ala Phe Gln Glu Tyr Lys Gly Gly Arg Gln Gln Thr 

65                  70                  75                  80  





Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Arg 

                85                  90                  95      





Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Glu Asn Tyr Glu Ala Asp Asp 

            100                 105                 110         





Ile Ile Gly Thr Leu Ala Ala Arg Ala Glu Gln Glu Gly Phe Glu Val 

        115                 120                 125             





Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro His 

    130                 135                 140                 





Val Thr Val Asp Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Pro Tyr 

145                 150                 155                 160 





Thr Pro Glu Thr Val Arg Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 

                165                 170                 175     





Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 

            180                 185                 190         





Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Arg Gln Phe 

        195                 200                 205             





Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 

    210                 215                 220                 





Lys Leu Lys Glu Thr Leu Arg Gln His Arg Glu Met Ala Leu Leu Ser 

225                 230                 235                 240 





Lys Lys Leu Ala Ala Ile Arg Arg Asp Ala Pro Val Glu Leu Ser Leu 

                245                 250                 255     





Asp Asp Ile Ala Tyr Gln Gly Glu Asp Arg Glu Lys Val Val Ala Leu 

            260                 265                 270         





Phe Lys Glu Leu Gly Phe Gln Ser Phe Leu Glu Lys Met Glu Ser Pro 

        275                 280                 285             





Ser Ser Glu Glu Glu Lys Pro Leu Ala Lys Met Ala Phe Thr Leu Ala 

    290                 295                 300                 





Asp Arg Val Thr Glu Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 

305                 310                 315                 320 





Glu Val Val Glu Glu Asn Tyr His Asp Ala Pro Ile Val Gly Ile Ala 

                325                 330                 335     





Val Val Asn Glu Arg Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 

            340                 345                 350         





Ala Asp Pro Gln Phe Val Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 

        355                 360                 365             





Ser Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 

    370                 375                 380                 





Ile Glu Leu Cys Gly Val Ser Phe Asp Leu Leu Leu Ala Ala Tyr Leu 

385                 390                 395                 400 





Leu Asp Pro Ala Gln Gly Val Asp Asp Val Ala Ala Ala Ala Lys Met 

                405                 410                 415     





Lys Gln Tyr Glu Ala Val Arg Pro Asp Glu Ala Val Tyr Gly Lys Gly 

            420                 425                 430         





Ala Lys Arg Ala Val Pro Asp Glu Pro Val Leu Ala Glu His Leu Val 

        435                 440                 445             





Arg Lys Ala Ala Ala Ile Trp Glu Leu Glu Arg Pro Phe Leu Asp Glu 

    450                 455                 460                 





Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Val Glu Leu Glu Gln Pro 

465                 470                 475                 480 





Leu Ser Ser Ile Leu Ala Glu Met Glu Phe Ala Gly Val Lys Val Asp 

                485                 490                 495     





Thr Lys Arg Leu Glu Gln Met Gly Lys Glu Leu Ala Glu Gln Leu Gly 

            500                 505                 510         





Thr Val Glu Gln Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 

        515                 520                 525             





Asn Ser Pro Lys Gln Leu Gly Val Ile Leu Phe Glu Lys Leu Gln Leu 

    530                 535                 540                 





Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 

545                 550                 555                 560 





Leu Glu Lys Leu Ala Pro Tyr His Glu Ile Val Glu Asn Ile Leu His

                565                 570                 575     





Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 

            580                 585                 590         





Lys Val Val Arg Pro Asp Thr Lys Lys Val His Thr Ile Phe Asn Gln 

        595                 600                 605             





Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Thr Glu Pro Asn Leu Gln 

    610                 615                 620                 





Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 

625                 630                 635                 640 





Val Pro Ser Glu Ser Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 

                645                 650                 655     





Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Met 

            660                 665                 670         





Glu Ala Phe Arg Arg Asp Leu Asp Ile His Thr Lys Thr Ala Met Asp 

        675                 680                 685             





Ile Phe Gln Val Ser Glu Asp Glu Val Thr Pro Asn Met Arg Arg Gln 

    690                 695                 700                 





Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 

705                 710                 715                 720 





Leu Ala Gln Asn Leu Asn Ile Ser Arg Lys Glu Ala Ala Glu Phe Ile 

                725                 730                 735     





Glu Arg Tyr Phe Gln Ser Phe Pro Gly Val Lys Arg Tyr Met Glu Asn 

            740                 745                 750         





Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 

        755                 760                 765             





Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 

    770                 775                 780                 





Ser Phe Ala Glu Arg Met Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 

785                 790                 795                 800 





Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Asn Ala Arg Leu Lys 

                805                 810                 815     





Glu Glu Arg Leu Gln Ala His Leu Leu Leu Gln Val His Asp Glu Leu 

            820                 825                 830         





Ile Leu Glu Ala Pro Lys Glu Glu Met Glu Arg Leu Cys Arg Leu Val 

        835                 840                 845             





Pro Glu Val Met Glu Gln Ala Val Thr Leu Arg Val Pro Leu Lys Val 

    850                 855                 860                 





Asp Tyr Arg Tyr Gly Ser Thr Trp Tyr Asp Ala Lys 

865                 870                 875     



