                         SEQUENCE LISTING

<110>  THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
 
<120>  Genetically-Edited Swine

<130>  P227228WO

<150>  GB 1517227.3
<151>  2015-09-29

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  41
<212>  DNA
<213>  Sus scrofa

<400>  1
agaggccctg ctgcagctgc agtttgatac tgatgaggac c                           41


<210>  2
<211>  41
<212>  DNA
<213>  Sus scrofa

<400>  2
tctccgggac gacgtcgacg tcaaactatg actactcctg g                           41


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  3

Asp Arg Ser Asp Leu Ser Arg 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  4

Arg Ser Asp Asn Leu Thr Arg 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  5

Thr Ser Gly Asn Leu Thr Arg 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  6

Leu Arg Gln Asp Leu Asn Lys 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  7

Thr Ser Ser Asn Leu Ser Arg 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  8

Ala Met Gln Thr Leu Arg Val 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  9

Asp Arg Ser His Leu Ala Arg 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  10

Arg Ser Asp Asn Leu Ser Glu 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  11

Lys Arg Cys Asn Leu Arg Cys 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFN DNA recognition helicase

<400>  12

Arg Ser Ala Val Leu Ser Glu 
1               5           


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer oSL1 sequence

<400>  13
gggtacaaag aggggtgagg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer oSL2 sequence

<400>  14
ctagctctgc cctttccaga                                                   20


<210>  15
<211>  1662
<212>  DNA
<213>  Sus scrofa

<400>  15
atggacgacc tcttccccct catcttcccc tcggagccgg ccccggcctc gggcccctat       60

gtggagatca tcgagcagcc caagcagcgg ggcatgcgct tccgctacaa gtgcgagggc      120

cgctcagccg gcagtatccc gggcgagagg agcacggata ccaccaagac ccaccccacc      180

atcaagatca atggctacac ggggccaggg acagtgcgca tctccctggt caccaaggac      240

ccccctcacc ggcctcaccc ccatgagctc gtggggaaag actgccggga tggcttctat      300

gaggctgagc tctgcccaga ccgctgcatc cacagcttcc agaacctggg gatccagtgt      360

gtaaagaagc gggacctgga acaggccatc aatcagcgca tccagaccaa caacaacccc      420

ttccaagttc ccatagaaga gcagcgcggg gactacgacc tgaatgctgt gcggctctgc      480

ttccaggtga cagtgcggga cccagcaggc aggcccctcc gcctgccgcc tgtcctctct      540

caccccatct ttgacaaccg tgcccccaac actgcagagc tcaagatctg ccgggtgaat      600

cggaactcgg ggagctgcct tgggggcgat gagatcttcc tgctgtgcga caaggtgcag      660

aaagaggaca tcgaggtgta tttcacgggc ccgggctggg aggcccgagg ctccttttca      720

caagccgacg tgcaccgaca agtggccatc gtgttccgga cgcctcccta cgcggacccc      780

agcctgcagg cccccgtgcg cgtctccatg cagctgcggc ggccttcgga tcgggagctc      840

agcgagccca tggaattcca gtacttgcca gacacagatg accggcaccg gattgaggag      900

aaacgcaaaa ggacctatga gacctttaag agcatcatga agaagagtcc tttcaatgga      960

cccaccgacc cccggcctgc aacccggcgc attgctgtgc cttcccgcag ctcagcttcc     1020

gtccccaagc cagctcccca gccctatccc tttacgccat ctctcagcac catcaacttt     1080

gacgagttca cgcccatggc ctttgcttct gggcagatcc caggccagac ctcagccttg     1140

gccccagccc ctgccccagt cctggtccag gccccagccc cggccccagc cccagccatg     1200

gcatcagctc tggcccaggc cccagcccct gtccccgtcc tagcccccgg ccttgctcag     1260

gctgtggccc cgcctgcccc taaaaccaac caggctgggg aagggacact gacagaggcc     1320

ctgctgcagc tgcagtttga tactgatgag gacctggggg ccctgctcgg caataacact     1380

gacccgaccg tgttcacgga cctggcatcc gtcgacaact ctgagtttca gcagctgctg     1440

aaccagggtg tatccatgcc cccccacaca gctgagccca tgctgatgga gtaccctgag     1500

gctataactc gcttggtgac agggtcccag agaccccctg acccagctcc cactcccctg     1560

ggggcctctg ggctcaccaa cggtctcctc tcgggggacg aagacttctc ctccattgcg     1620

gacatggact tctcagccct tctgagtcag atcagctcct aa                        1662


<210>  16
<211>  553
<212>  PRT
<213>  Sus scrofa

<400>  16

Met Asp Asp Leu Phe Pro Leu Ile Phe Pro Ser Glu Pro Ala Pro Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Asn Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ala Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg 
    290                 295                 300                 


Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Asn Gly 
305                 310                 315                 320 


Pro Thr Asp Pro Arg Pro Ala Thr Arg Arg Ile Ala Val Pro Ser Arg 
                325                 330                 335     


Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr 
            340                 345                 350         


Pro Ser Leu Ser Thr Ile Asn Phe Asp Glu Phe Thr Pro Met Ala Phe 
        355                 360                 365             


Ala Ser Gly Gln Ile Pro Gly Gln Thr Ser Ala Leu Ala Pro Ala Pro 
    370                 375                 380                 


Ala Pro Val Leu Val Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met 
385                 390                 395                 400 


Ala Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro 
                405                 410                 415     


Gly Leu Ala Gln Ala Val Ala Pro Pro Ala Pro Lys Thr Asn Gln Ala 
            420                 425                 430         


Gly Glu Gly Thr Leu Thr Glu Ala Leu Leu Gln Leu Gln Phe Asp Thr 
        435                 440                 445             


Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Asn Thr Asp Pro Thr Val 
    450                 455                 460                 


Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu 
465                 470                 475                 480 


Asn Gln Gly Val Ser Met Pro Pro His Thr Ala Glu Pro Met Leu Met 
                485                 490                 495     


Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro 
            500                 505                 510         


Pro Asp Pro Ala Pro Thr Pro Leu Gly Ala Ser Gly Leu Thr Asn Gly 
        515                 520                 525             


Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe 
    530                 535                 540                 


Ser Ala Leu Leu Ser Gln Ile Ser Ser 
545                 550             


<210>  17
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein encoded by the edited RELA gene

<400>  17

Leu Leu Gln Leu Gln Phe Asp Ala Asp Glu Asp Leu Gly Ala Leu Leu 
1               5                   10                  15      


Gly Asn Asn Thr Asp Pro Thr Val Phe Thr Asp Leu Ala Ser Val Asp 
            20                  25                  30          


Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Val Pro Met Pro Pro 
        35                  40                  45              


His Thr Ala Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg 
    50                  55                  60                  


Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro Ala Pro Thr Pro Leu 
65                  70                  75                  80  


Gly Ala Ser Gly Leu Thr Asn Gly Leu Leu Pro Asp Gly Glu Asp Phe 
                85                  90                  95      


Ser Ser Ile Ala Asp Met 
            100         


<210>  18
<211>  15
<212>  DNA
<213>  Sus scrofa

<400>  18
gatactgatg aggac                                                        15


<210>  19
<211>  15
<212>  DNA
<213>  Sus scrofa

<400>  19
ctccgggacg acgtc                                                        15


<210>  20
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence which prevents recutting by the SSN

<400>  20
gatgcagacg aggac                                                        15


<210>  21
<211>  23
<212>  DNA
<213>  Sus scrofa

<400>  21
tgcagtttga tactgatgag gac                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  post-introgression sequence

<400>  22
tgcagtttga tgcagacgag gac                                               23


<210>  23
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein encoded by the edited RELA gene

<400>  23

Ala Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Asn Thr Asp Pro Thr 
1               5                   10                  15      


Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu 
            20                  25                  30          


Leu Asn Gln Gly Val Pro Met Pro Pro His Thr Ala Glu Pro Met Leu 
        35                  40                  45              


Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg 
    50                  55                  60                  


Pro Pro Asp Pro Ala Pro Thr Pro Leu Gly Ala Ser Gly Leu Thr Asn 
65                  70                  75                  80  


Gly Leu Leu Pro 
                


