                         SEQUENCE LISTING

<110>  Swedish Orphan Biovitrum AB
 
<120>  Modified enzyme

<130>  21078288

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  342
<212>  PRT
<213>  HOMO SAPIENS

<400>  1

Cys Tyr Gly Asp Ser Gly Gln Pro Val Asp Trp Phe Val Val Tyr Lys 
1               5                   10                  15      


Leu Pro Ala Leu Arg Gly Ser Gly Glu Ala Ala Gln Arg Gly Leu Gln 
            20                  25                  30          


Tyr Lys Tyr Leu Asp Glu Ser Ser Gly Gly Trp Arg Asp Gly Arg Ala 
        35                  40                  45              


Leu Ile Asn Ser Pro Glu Gly Ala Val Gly Arg Ser Leu Gln Pro Leu 
    50                  55                  60                  


Tyr Arg Ser Asn Thr Ser Gln Leu Ala Phe Leu Leu Tyr Asn Asp Gln 
65                  70                  75                  80  


Pro Pro Gln Pro Ser Lys Ala Gln Asp Ser Ser Met Arg Gly His Thr 
                85                  90                  95      


Lys Gly Val Leu Leu Leu Asp His Asp Gly Gly Phe Trp Leu Val His 
            100                 105                 110         


Ser Val Pro Asn Phe Pro Pro Pro Ala Ser Ser Ala Ala Tyr Ser Trp 
        115                 120                 125             


Pro His Ser Ala Cys Thr Tyr Gly Gln Thr Leu Leu Cys Val Ser Phe 
    130                 135                 140                 


Pro Phe Ala Gln Phe Ser Lys Met Gly Lys Gln Leu Thr Tyr Thr Tyr 
145                 150                 155                 160 


Pro Trp Val Tyr Asn Tyr Gln Leu Glu Gly Ile Phe Ala Gln Glu Phe 
                165                 170                 175     


Pro Asp Leu Glu Asn Val Val Lys Gly His His Val Ser Gln Glu Pro 
            180                 185                 190         


Trp Asn Ser Ser Ile Thr Leu Thr Ser Gln Ala Gly Ala Val Phe Gln 
        195                 200                 205             


Ser Phe Ala Lys Phe Ser Lys Phe Gly Asp Asp Leu Tyr Ser Gly Trp 
    210                 215                 220                 


Leu Ala Ala Ala Leu Gly Thr Asn Leu Gln Val Gln Phe Trp His Lys 
225                 230                 235                 240 


Thr Val Gly Ile Leu Pro Ser Asn Cys Ser Asp Ile Trp Gln Val Leu 
                245                 250                 255     


Asn Val Asn Gln Ile Ala Phe Pro Gly Pro Ala Gly Pro Ser Phe Asn 
            260                 265                 270         


Ser Thr Glu Asp His Ser Lys Trp Cys Val Ser Pro Lys Gly Pro Trp 
        275                 280                 285             


Thr Cys Val Gly Asp Met Asn Arg Asn Gln Gly Glu Glu Gln Arg Gly 
    290                 295                 300                 


Gly Gly Thr Leu Cys Ala Gln Leu Pro Ala Leu Trp Lys Ala Phe Gln 
305                 310                 315                 320 


Pro Leu Val Lys Asn Tyr Gln Pro Cys Asn Gly Met Ala Arg Lys Pro 
                325                 330                 335     


Ser Arg Ala Tyr Lys Ile 
            340         


<210>  2
<211>  862
<212>  PRT
<213>  HOMO SAPIENS

<400>  2

Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys Asn 
1               5                   10                  15      


Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val His 
            20                  25                  30          


Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg Phe 
        35                  40                  45              


Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr Ser 
    50                  55                  60                  


Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val Asn 
65                  70                  75                  80  


Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn Glu 
                85                  90                  95      


Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe Asp 
            100                 105                 110         


Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe Gln 
        115                 120                 125             


Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg Tyr 
    130                 135                 140                 


Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys His 
145                 150                 155                 160 


Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp Gly 
                165                 170                 175     


Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu Ala 
            180                 185                 190         


Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr Asp 
        195                 200                 205             


Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp Val 
    210                 215                 220                 


Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro Lys 
225                 230                 235                 240 


Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys Arg 
                245                 250                 255     


Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu Thr 
            260                 265                 270         


Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr Val 
        275                 280                 285             


Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys Val 
    290                 295                 300                 


Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser Pro 
305                 310                 315                 320 


Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu Lys 
                325                 330                 335     


Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr Ser 
            340                 345                 350         


Glu Leu Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met Asn 
        355                 360                 365             


Thr Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe Tyr 
    370                 375                 380                 


Glu Leu Cys Asp Glu Leu Gly Ile Met Val Trp Gln Asp Phe Met Phe 
385                 390                 395                 400 


Ala Cys Ala Leu Tyr Pro Thr Asp Gln Gly Phe Leu Asp Ser Val Thr 
                405                 410                 415     


Ala Glu Val Ala Tyr Gln Ile Lys Arg Leu Lys Ser His Pro Ser Ile 
            420                 425                 430         


Ile Ile Trp Ser Gly Asn Asn Glu Asn Glu Glu Ala Leu Met Met Asn 
        435                 440                 445             


Trp Tyr His Ile Ser Phe Thr Asp Arg Pro Ile Tyr Ile Lys Asp Tyr 
    450                 455                 460                 


Val Thr Leu Tyr Val Lys Asn Ile Arg Glu Leu Val Leu Ala Gly Asp 
465                 470                 475                 480 


Lys Ser Arg Pro Phe Ile Thr Ser Ser Pro Thr Asn Gly Ala Glu Thr 
                485                 490                 495     


Val Ala Glu Ala Trp Val Ser Gln Asn Pro Asn Ser Asn Tyr Phe Gly 
            500                 505                 510         


Asp Val His Phe Tyr Asp Tyr Ile Ser Asp Cys Trp Asn Trp Lys Val 
        515                 520                 525             


Phe Pro Lys Ala Arg Phe Ala Ser Glu Tyr Gly Tyr Gln Ser Trp Pro 
    530                 535                 540                 


Ser Phe Ser Thr Leu Glu Lys Val Ser Ser Thr Glu Asp Trp Ser Phe 
545                 550                 555                 560 


Asn Ser Lys Phe Ser Leu His Arg Gln His His Glu Gly Gly Asn Lys 
                565                 570                 575     


Gln Met Leu Tyr Gln Ala Gly Leu His Phe Lys Leu Pro Gln Ser Thr 
            580                 585                 590         


Asp Pro Leu Arg Thr Phe Lys Asp Thr Ile Tyr Leu Thr Gln Val Met 
        595                 600                 605             


Gln Ala Gln Cys Val Lys Thr Glu Thr Glu Phe Tyr Arg Arg Ser Arg 
    610                 615                 620                 


Ser Glu Ile Val Asp Gln Gln Gly His Thr Met Gly Ala Leu Tyr Trp 
625                 630                 635                 640 


Gln Leu Asn Asp Ile Trp Gln Ala Pro Ser Trp Ala Ser Leu Glu Tyr 
                645                 650                 655     


Gly Gly Lys Trp Lys Met Leu His Tyr Phe Ala Gln Asn Phe Phe Ala 
            660                 665                 670         


Pro Leu Leu Pro Val Gly Phe Glu Asn Glu Asn Thr Phe Tyr Ile Tyr 
        675                 680                 685             


Gly Val Ser Asp Leu His Ser Asp Tyr Ser Met Thr Leu Ser Val Arg 
    690                 695                 700                 


Val His Thr Trp Ser Ser Leu Glu Pro Val Cys Ser Arg Val Thr Glu 
705                 710                 715                 720 


Arg Phe Val Met Lys Gly Gly Glu Ala Val Cys Leu Tyr Glu Glu Pro 
                725                 730                 735     


Val Ser Glu Leu Leu Arg Arg Cys Gly Asn Cys Thr Arg Glu Ser Cys 
            740                 745                 750         


Val Val Ser Phe Tyr Leu Ser Ala Asp His Glu Leu Leu Ser Pro Thr 
        755                 760                 765             


Asn Tyr His Phe Leu Ser Ser Pro Lys Glu Ala Val Gly Leu Cys Lys 
    770                 775                 780                 


Ala Gln Ile Thr Ala Ile Ile Ser Gln Gln Gly Asp Ile Phe Val Phe 
785                 790                 795                 800 


Asp Leu Glu Thr Ser Ala Val Ala Pro Phe Val Trp Leu Asp Val Gly 
                805                 810                 815     


Ser Ile Pro Gly Arg Phe Ser Asp Asn Gly Phe Leu Met Thr Glu Lys 
            820                 825                 830         


Thr Arg Thr Ile Leu Phe Tyr Pro Trp Glu Pro Thr Ser Lys Asn Glu 
        835                 840                 845             


Leu Glu Gln Ser Phe His Val Thr Ser Leu Thr Asp Ile Tyr 
    850                 855                 860         


<210>  3
<211>  232
<212>  PRT
<213>  HOMO SAPIENS

<400>  3

Asp Lys Arg Leu Arg Asp Asn His Glu Trp Lys Lys Leu Ile Met Val 
1               5                   10                  15      


Gln His Trp Pro Glu Thr Val Cys Glu Lys Ile Gln Asn Asp Cys Arg 
            20                  25                  30          


Asp Pro Pro Asp Tyr Trp Thr Ile His Gly Leu Trp Pro Asp Lys Ser 
        35                  40                  45              


Glu Gly Cys Asn Arg Ser Trp Pro Phe Asn Leu Glu Glu Ile Lys Asp 
    50                  55                  60                  


Leu Leu Pro Glu Met Arg Ala Tyr Trp Pro Asp Val Ile His Ser Phe 
65                  70                  75                  80  


Pro Asn Arg Ser Arg Phe Trp Lys His Glu Trp Glu Lys His Gly Thr 
                85                  90                  95      


Cys Ala Ala Gln Val Asp Ala Leu Asn Ser Gln Lys Lys Tyr Phe Gly 
            100                 105                 110         


Arg Ser Leu Glu Leu Tyr Arg Glu Leu Asp Leu Asn Ser Val Leu Leu 
        115                 120                 125             


Lys Leu Gly Ile Lys Pro Ser Ile Asn Tyr Tyr Gln Val Ala Asp Phe 
    130                 135                 140                 


Lys Asp Ala Leu Ala Arg Val Tyr Gly Val Ile Pro Lys Ile Gln Cys 
145                 150                 155                 160 


Leu Pro Pro Ser Gln Asp Glu Glu Val Gln Thr Ile Gly Gln Ile Glu 
                165                 170                 175     


Leu Cys Leu Thr Lys Gln Asp Gln Gln Leu Gln Asn Cys Thr Glu Pro 
            180                 185                 190         


Gly Glu Gln Pro Ser Pro Lys Gln Glu Val Trp Leu Ala Asn Gly Ala 
        195                 200                 205             


Ala Glu Ser Arg Gly Leu Arg Val Cys Glu Asp Gly Pro Val Phe Tyr 
    210                 215                 220                 


Pro Pro Pro Lys Lys Thr Lys His 
225                 230         


<210>  4
<211>  962
<212>  PRT
<213>  HOMO SAPIENS

<400>  4

Gly Gly Tyr Glu Thr Cys Pro Thr Val Gln Pro Asn Met Leu Asn Val 
1               5                   10                  15      


His Leu Leu Pro His Thr His Asp Asp Val Gly Trp Leu Lys Thr Val 
            20                  25                  30          


Asp Gln Tyr Phe Tyr Gly Ile Lys Asn Asp Ile Gln His Ala Gly Val 
        35                  40                  45              


Gln Tyr Ile Leu Asp Ser Val Ile Ser Ala Leu Leu Ala Asp Pro Thr 
    50                  55                  60                  


Arg Arg Phe Ile Tyr Val Glu Ile Ala Phe Phe Ser Arg Trp Trp His 
65                  70                  75                  80  


Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg Asp Leu Val Arg Gln 
                85                  90                  95      


Gly Arg Leu Glu Phe Ala Asn Gly Gly Trp Val Met Asn Asp Glu Ala 
            100                 105                 110         


Ala Thr His Tyr Gly Ala Ile Val Asp Gln Met Thr Leu Gly Leu Arg 
        115                 120                 125             


Phe Leu Glu Asp Thr Phe Gly Asn Asp Gly Arg Pro Arg Val Ala Trp 
    130                 135                 140                 


His Ile Asp Pro Phe Gly His Ser Arg Glu Gln Ala Ser Leu Phe Ala 
145                 150                 155                 160 


Gln Met Gly Phe Asp Gly Phe Phe Phe Gly Arg Leu Asp Tyr Gln Asp 
                165                 170                 175     


Lys Trp Val Arg Met Gln Lys Leu Glu Met Glu Gln Val Trp Arg Ala 
            180                 185                 190         


Ser Thr Ser Leu Lys Pro Pro Thr Ala Asp Leu Phe Thr Gly Val Leu 
        195                 200                 205             


Pro Asn Gly Tyr Asn Pro Pro Arg Asn Leu Cys Trp Asp Val Leu Cys 
    210                 215                 220                 


Val Asp Gln Pro Leu Val Glu Asp Pro Arg Ser Pro Glu Tyr Asn Ala 
225                 230                 235                 240 


Lys Glu Leu Val Asp Tyr Phe Leu Asn Val Ala Thr Ala Gln Gly Arg 
                245                 250                 255     


Tyr Tyr Arg Thr Asn His Thr Val Met Thr Met Gly Ser Asp Phe Gln 
            260                 265                 270         


Tyr Glu Asn Ala Asn Met Trp Phe Lys Asn Leu Asp Lys Leu Ile Arg 
        275                 280                 285             


Leu Val Asn Ala Gln Gln Ala Lys Gly Ser Ser Val His Val Leu Tyr 
    290                 295                 300                 


Ser Thr Pro Ala Cys Tyr Leu Trp Glu Leu Asn Lys Ala Asn Leu Thr 
305                 310                 315                 320 


Trp Ser Val Lys His Asp Asp Phe Phe Pro Tyr Ala Asp Gly Pro His 
                325                 330                 335     


Gln Phe Trp Thr Gly Tyr Phe Ser Ser Arg Pro Ala Leu Lys Arg Tyr 
            340                 345                 350         


Glu Arg Leu Ser Tyr Asn Phe Leu Gln Val Cys Asn Gln Leu Glu Ala 
        355                 360                 365             


Leu Val Gly Leu Ala Ala Asn Val Gly Pro Tyr Gly Ser Gly Asp Ser 
    370                 375                 380                 


Ala Pro Leu Asn Glu Ala Met Ala Val Leu Gln His His Asp Ala Val 
385                 390                 395                 400 


Ser Gly Thr Ser Arg Gln His Val Ala Asn Asp Tyr Ala Arg Gln Leu 
                405                 410                 415     


Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu Ser Asn Ala Leu Ala 
            420                 425                 430         


Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe Cys Gln Gln Leu Asn 
        435                 440                 445             


Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala Arg Phe Gln Val Ile 
    450                 455                 460                 


Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp Met Val Arg Leu Pro 
465                 470                 475                 480 


Val Ser Glu Gly Val Phe Val Val Lys Asp Pro Asn Gly Arg Thr Val 
                485                 490                 495     


Pro Ser Asp Val Val Ile Phe Pro Ser Ser Asp Ser Gln Ala His Pro 
            500                 505                 510         


Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala Leu Gly Phe Ser Thr 
        515                 520                 525             


Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro Gln Ala Arg Ala Pro 
    530                 535                 540                 


Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala Leu Thr Ile Glu Asn 
545                 550                 555                 560 


Glu His Ile Arg Ala Thr Phe Asp Pro Asp Thr Gly Leu Leu Met Glu 
                565                 570                 575     


Ile Met Asn Met Asn Gln Gln Leu Leu Leu Pro Val Arg Gln Thr Phe 
            580                 585                 590         


Phe Trp Tyr Asn Ala Ser Ile Gly Asp Asn Glu Ser Asp Gln Ala Ser 
        595                 600                 605             


Gly Ala Tyr Ile Phe Arg Pro Asn Gln Gln Lys Pro Leu Pro Val Ser 
    610                 615                 620                 


Arg Trp Ala Gln Ile His Leu Val Lys Thr Pro Leu Val Gln Glu Val 
625                 630                 635                 640 


His Gln Asn Phe Ser Ala Trp Cys Ser Gln Val Val Arg Leu Tyr Pro 
                645                 650                 655     


Gly Gln Arg His Leu Glu Leu Glu Trp Ser Val Gly Pro Ile Pro Val 
            660                 665                 670         


Gly Asp Thr Trp Gly Lys Glu Val Ile Ser Arg Phe Asp Thr Pro Leu 
        675                 680                 685             


Glu Thr Lys Gly Arg Phe Tyr Thr Asp Ser Asn Gly Arg Glu Ile Leu 
    690                 695                 700                 


Glu Arg Arg Arg Asp Tyr Arg Pro Thr Trp Lys Leu Asn Gln Thr Glu 
705                 710                 715                 720 


Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn Thr Arg Ile Tyr Ile Thr 
                725                 730                 735     


Asp Gly Asn Met Gln Leu Thr Val Leu Thr Asp Arg Ser Gln Gly Gly 
            740                 745                 750         


Ser Ser Leu Arg Asp Gly Ser Leu Glu Leu Met Val His Arg Arg Leu 
        755                 760                 765             


Leu Lys Asp Asp Gly Arg Gly Val Ser Glu Pro Leu Met Glu Asn Gly 
    770                 775                 780                 


Ser Gly Ala Trp Val Arg Gly Arg His Leu Val Leu Leu Asp Thr Ala 
785                 790                 795                 800 


Gln Ala Ala Ala Ala Gly His Arg Leu Leu Ala Glu Gln Glu Val Leu 
                805                 810                 815     


Ala Pro Gln Val Val Leu Ala Pro Gly Gly Gly Ala Ala Tyr Asn Leu 
            820                 825                 830         


Gly Ala Pro Pro Arg Thr Gln Phe Ser Gly Leu Arg Arg Asp Leu Pro 
        835                 840                 845             


Pro Ser Val His Leu Leu Thr Leu Ala Ser Trp Gly Pro Glu Met Val 
    850                 855                 860                 


Leu Leu Arg Leu Glu His Gln Phe Ala Val Gly Glu Asp Ser Gly Arg 
865                 870                 875                 880 


Asn Leu Ser Ala Pro Val Thr Leu Asn Leu Arg Asp Leu Phe Ser Thr 
                885                 890                 895     


Phe Thr Ile Thr Arg Leu Gln Glu Thr Thr Leu Val Ala Asn Gln Leu 
            900                 905                 910         


Arg Glu Ala Ala Ser Arg Leu Lys Trp Thr Thr Asn Thr Gly Pro Thr 
        915                 920                 925             


Pro His Gln Thr Pro Tyr Gln Leu Asp Pro Ala Asn Ile Thr Leu Glu 
    930                 935                 940                 


Pro Met Glu Ile Arg Thr Phe Leu Ala Ser Val Gln Trp Lys Glu Val 
945                 950                 955                 960 


Asp Gly 
        


<210>  5
<211>  544
<212>  PRT
<213>  HOMO SAPIENS

<400>  5

Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro Pro Gly Trp 
1               5                   10                  15      


Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser Leu Thr Phe 
            20                  25                  30          


Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu Val Gln Ala 
        35                  40                  45              


Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu Thr Leu Glu 
    50                  55                  60                  


Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu His Thr Val 
65                  70                  75                  80  


Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His Ser Val Ile 
                85                  90                  95      


Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln Ala Glu Leu 
            100                 105                 110         


Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly Pro Thr Glu 
        115                 120                 125             


Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro Gln Ala Leu 
    130                 135                 140                 


Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe Pro Pro Thr 
145                 150                 155                 160 


Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly Thr Val Gly 
                165                 170                 175     


Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg Tyr Asn Leu 
            180                 185                 190         


Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser Gln Ala Cys 
        195                 200                 205             


Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu Ala Gln Phe 
    210                 215                 220                 


Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser Val Ala Arg 
225                 230                 235                 240 


Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu Ala Ser Leu 
                245                 250                 255     


Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser Thr Trp Val 
            260                 265                 270         


Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe Leu Gln Trp 
        275                 280                 285             


Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val His Thr Val 
    290                 295                 300                 


Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr Ile Gln Arg 
305                 310                 315                 320 


Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu Thr Leu Leu 
                325                 330                 335     


Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val Ser Gly Arg 
            340                 345                 350         


His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr Val Thr Thr 
        355                 360                 365             


Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr Asn Glu Ile 
    370                 375                 380                 


Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe Pro Arg Pro 
385                 390                 395                 400 


Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser Ser Pro His 
                405                 410                 415     


Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala Tyr Pro Asp 
            420                 425                 430         


Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn Arg Val Pro 
        435                 440                 445             


Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val Phe Gly Gly 
    450                 455                 460                 


Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly Arg Pro Pro 
465                 470                 475                 480 


Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly Ala Gly Leu 
                485                 490                 495     


Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp Glu Glu Val 
            500                 505                 510         


Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro Val Thr Gly 
        515                 520                 525             


Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu Leu Asn Pro 
    530                 535                 540                 


<210>  6
<211>  397
<212>  PRT
<213>  HOMO SAPIENS

<400>  6

Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser Val Leu Trp Asn 
1               5                   10                  15      


Val Pro Ser Ala His Cys Glu Ala Arg Phe Gly Val His Leu Pro Leu 
            20                  25                  30          


Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His Phe His Gly Gln 
        35                  40                  45              


Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu Tyr Pro Tyr Phe 
    50                  55                  60                  


Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro Gln Ala Leu Pro 
65                  70                  75                  80  


Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile His His Ser Leu 
                85                  90                  95      


Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp Glu Glu Trp Cys 
            100                 105                 110         


Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala Tyr Gln Ala Ala 
        115                 120                 125             


Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu Asp Pro Gln Glu 
    130                 135                 140                 


Gln Leu Tyr Lys Ala Tyr Thr Gly Phe Glu Gln Ala Ala Arg Ala Leu 
145                 150                 155                 160 


Met Glu Asp Thr Leu Arg Val Ala Gln Ala Leu Arg Pro His Gly Leu 
                165                 170                 175     


Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly Trp His Ser Met 
            180                 185                 190         


Ala Ser Asn Tyr Thr Gly Arg Cys His Ala Ala Thr Leu Ala Arg Asn 
        195                 200                 205             


Thr Gln Leu His Trp Leu Trp Ala Ala Ser Ser Ala Leu Phe Pro Ser 
    210                 215                 220                 


Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala His His Gln Ala Phe Val 
225                 230                 235                 240 


Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala Leu Val Gly His Arg 
                245                 250                 255     


His Pro Leu Pro Val Leu Ala Tyr Val Arg Leu Thr His Arg Arg Ser 
            260                 265                 270         


Gly Arg Phe Leu Ser Gln Asp Asp Leu Val Gln Ser Ile Gly Val Ser 
        275                 280                 285             


Ala Ala Leu Gly Ala Ala Gly Val Val Leu Trp Gly Asp Leu Ser Leu 
    290                 295                 300                 


Ser Ser Ser Glu Glu Glu Cys Trp His Leu His Asp Tyr Leu Val Asp 
305                 310                 315                 320 


Thr Leu Gly Pro Tyr Val Ile Asn Val Thr Arg Ala Ala Met Ala Cys 
                325                 330                 335     


Ser His Gln Arg Cys His Gly His Gly Arg Cys Ala Arg Arg Asp Pro 
            340                 345                 350         


Gly Gln Met Glu Ala Phe Leu His Leu Trp Pro Asp Gly Ser Leu Gly 
        355                 360                 365             


Asp Trp Lys Ser Phe Ser Cys His Cys Tyr Trp Gly Trp Ala Gly Pro 
    370                 375                 380                 


Thr Cys Gln Glu Pro Arg Pro Gly Pro Lys Glu Ala Val 
385                 390                 395         


<210>  7
<211>  317
<212>  PRT
<213>  HOMO SAPIENS

<400>  7

Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp Lys 
1               5                   10                  15      


Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg Arg 
            20                  25                  30          


Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly Glu 
        35                  40                  45              


Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe Gly 
    50                  55                  60                  


Asp Met Thr Asn Glu Glu Phe Arg Gln Met Met Gly Cys Phe Arg Asn 
65                  70                  75                  80  


Gln Lys Phe Arg Lys Gly Lys Val Phe Arg Glu Pro Leu Phe Leu Asp 
                85                  90                  95      


Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro Val 
            100                 105                 110         


Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr Gly 
        115                 120                 125             


Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser Leu 
    130                 135                 140                 


Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln Gly 
145                 150                 155                 160 


Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu Asn 
                165                 170                 175     


Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp Glu 
            180                 185                 190         


Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly Phe 
        195                 200                 205             


Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val Ala 
    210                 215                 220                 


Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser Phe 
225                 230                 235                 240 


Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Lys 
                245                 250                 255     


Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly Ala 
            260                 265                 270         


Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Pro 
        275                 280                 285             


Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn Asn 
    290                 295                 300                 


His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val 
305                 310                 315         


<210>  8
<211>  312
<212>  PRT
<213>  HOMO SAPIENS

<400>  8

Ile Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe 
1               5                   10                  15      


Arg Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys Pro 
            20                  25                  30          


Thr Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val 
        35                  40                  45              


Phe Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu 
    50                  55                  60                  


Gly His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr Leu 
65                  70                  75                  80  


Thr Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly 
                85                  90                  95      


Asn Cys Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp 
            100                 105                 110         


Cys Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His 
        115                 120                 125             


Trp Lys Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser Gly Asn 
    130                 135                 140                 


Met Phe Asn Gln Met Ala Lys Trp Val Lys Gln Asp Asn Glu Thr Gly 
145                 150                 155                 160 


Ile Tyr Tyr Glu Thr Trp Asn Val Lys Ala Ser Pro Glu Lys Gly Ala 
                165                 170                 175     


Glu Thr Trp Phe Asp Ser Tyr Asp Cys Ser Lys Phe Val Leu Arg Thr 
            180                 185                 190         


Phe Asn Lys Leu Ala Glu Phe Gly Ala Glu Phe Lys Asn Ile Glu Thr 
        195                 200                 205             


Asn Tyr Thr Arg Ile Phe Leu Tyr Ser Gly Glu Pro Thr Tyr Leu Gly 
    210                 215                 220                 


Asn Glu Thr Ser Val Phe Gly Pro Thr Gly Asn Lys Thr Leu Gly Leu 
225                 230                 235                 240 


Ala Ile Lys Arg Phe Tyr Tyr Pro Phe Lys Pro His Leu Pro Thr Lys 
                245                 250                 255     


Glu Phe Leu Leu Ser Leu Leu Gln Ile Phe Asp Ala Val Ile Val His 
            260                 265                 270         


Lys Gln Phe Tyr Leu Phe Tyr Asn Phe Glu Tyr Trp Phe Leu Pro Met 
        275                 280                 285             


Lys Phe Pro Phe Ile Lys Ile Thr Tyr Glu Glu Ile Pro Leu Pro Ile 
    290                 295                 300                 


Arg Asn Lys Thr Leu Ser Gly Leu 
305                 310         


<210>  9
<211>  497
<212>  PRT
<213>  HOMO SAPIENS

<400>  9

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  10
<211>  435
<212>  PRT
<213>  HOMO SAPIENS

<400>  10

Gln Pro Pro Arg Arg Tyr Thr Pro Asp Trp Pro Ser Leu Asp Ser Arg 
1               5                   10                  15      


Pro Leu Pro Ala Trp Phe Asp Glu Ala Lys Phe Gly Val Phe Ile His 
            20                  25                  30          


Trp Gly Val Phe Ser Val Pro Ala Trp Gly Ser Glu Trp Phe Trp Trp 
        35                  40                  45              


His Trp Gln Gly Glu Gly Arg Pro Gln Tyr Gln Arg Phe Met Arg Asp 
    50                  55                  60                  


Asn Tyr Pro Pro Gly Phe Ser Tyr Ala Asp Phe Gly Pro Gln Phe Thr 
65                  70                  75                  80  


Ala Arg Phe Phe His Pro Glu Glu Trp Ala Asp Leu Phe Gln Ala Ala 
                85                  90                  95      


Gly Ala Lys Tyr Val Val Leu Thr Thr Lys His His Glu Gly Phe Thr 
            100                 105                 110         


Asn Trp Pro Ser Pro Val Ser Trp Asn Trp Asn Ser Lys Asp Val Gly 
        115                 120                 125             


Pro His Arg Asp Leu Val Gly Glu Leu Gly Thr Ala Leu Arg Lys Arg 
    130                 135                 140                 


Asn Ile Arg Tyr Gly Leu Tyr His Ser Leu Leu Glu Trp Phe His Pro 
145                 150                 155                 160 


Leu Tyr Leu Leu Asp Lys Lys Asn Gly Phe Lys Thr Gln His Phe Val 
                165                 170                 175     


Ser Ala Lys Thr Met Pro Glu Leu Tyr Asp Leu Val Asn Ser Tyr Lys 
            180                 185                 190         


Pro Asp Leu Ile Trp Ser Asp Gly Glu Trp Glu Cys Pro Asp Thr Tyr 
        195                 200                 205             


Trp Asn Ser Thr Asn Phe Leu Ser Trp Leu Tyr Asn Asp Ser Pro Val 
    210                 215                 220                 


Lys Asp Glu Val Val Val Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys 
225                 230                 235                 240 


His His Gly Gly Tyr Tyr Asn Cys Glu Asp Lys Phe Lys Pro Gln Ser 
                245                 250                 255     


Leu Pro Asp His Lys Trp Glu Met Cys Thr Ser Ile Asp Lys Phe Ser 
            260                 265                 270         


Trp Gly Tyr Arg Arg Asp Met Ala Leu Ser Asp Val Thr Glu Glu Ser 
        275                 280                 285             


Glu Ile Ile Ser Glu Leu Val Gln Thr Val Ser Leu Gly Gly Asn Tyr 
    290                 295                 300                 


Leu Leu Asn Ile Gly Pro Thr Lys Asp Gly Leu Ile Val Pro Ile Phe 
305                 310                 315                 320 


Gln Glu Arg Leu Leu Ala Val Gly Lys Trp Leu Ser Ile Asn Gly Glu 
                325                 330                 335     


Ala Ile Tyr Ala Ser Lys Pro Trp Arg Val Gln Trp Glu Lys Asn Thr 
            340                 345                 350         


Thr Ser Val Trp Tyr Thr Ser Lys Gly Ser Ala Val Tyr Ala Ile Phe 
        355                 360                 365             


Leu His Trp Pro Glu Asn Gly Val Leu Asn Leu Glu Ser Pro Ile Thr 
    370                 375                 380                 


Thr Ser Thr Thr Lys Ile Thr Met Leu Gly Ile Gln Gly Asp Leu Lys 
385                 390                 395                 400 


Trp Ser Thr Asp Pro Asp Lys Gly Leu Phe Ile Ser Leu Pro Gln Leu 
                405                 410                 415     


Pro Pro Ser Ala Val Pro Ala Glu Phe Ala Trp Thr Ile Lys Leu Thr 
            420                 425                 430         


Gly Val Lys 
        435 


<210>  11
<211>  697
<212>  PRT
<213>  HOMO SAPIENS

<400>  11

Ala Ala Pro Ala Val Leu Gly Glu Val Asp Thr Ser Leu Val Leu Ser 
1               5                   10                  15      


Ser Met Glu Glu Ala Lys Gln Leu Val Asp Lys Ala Tyr Lys Glu Arg 
            20                  25                  30          


Arg Glu Ser Ile Lys Gln Arg Leu Arg Ser Gly Ser Ala Ser Pro Met 
        35                  40                  45              


Glu Leu Leu Ser Tyr Phe Lys Gln Pro Val Ala Ala Thr Arg Thr Ala 
    50                  55                  60                  


Val Arg Ala Ala Asp Tyr Leu His Val Ala Leu Asp Leu Leu Glu Arg 
65                  70                  75                  80  


Lys Leu Arg Ser Leu Trp Arg Arg Pro Phe Asn Val Thr Asp Val Leu 
                85                  90                  95      


Thr Pro Ala Gln Leu Asn Val Leu Ser Lys Ser Ser Gly Cys Ala Tyr 
            100                 105                 110         


Gln Asp Val Gly Val Thr Cys Pro Glu Gln Asp Lys Tyr Arg Thr Ile 
        115                 120                 125             


Thr Gly Met Cys Asn Asn Arg Arg Ser Pro Thr Leu Gly Ala Ser Asn 
    130                 135                 140                 


Arg Ala Phe Val Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Phe Ser 
145                 150                 155                 160 


Leu Pro Tyr Gly Trp Thr Pro Gly Val Lys Arg Asn Gly Phe Pro Val 
                165                 170                 175     


Ala Leu Ala Arg Ala Val Ser Asn Glu Ile Val Arg Phe Pro Thr Asp 
            180                 185                 190         


Gln Leu Thr Pro Asp Gln Glu Arg Ser Leu Met Phe Met Gln Trp Gly 
        195                 200                 205             


Gln Leu Leu Asp His Asp Leu Asp Phe Thr Pro Glu Pro Ala Ala Arg 
    210                 215                 220                 


Ala Ser Phe Val Thr Gly Val Asn Cys Glu Thr Ser Cys Val Gln Gln 
225                 230                 235                 240 


Pro Pro Cys Phe Pro Leu Lys Ile Pro Pro Asn Asp Pro Arg Ile Lys 
                245                 250                 255     


Asn Gln Ala Asp Cys Ile Pro Phe Phe Arg Ser Cys Pro Ala Cys Pro 
            260                 265                 270         


Gly Ser Asn Ile Thr Ile Arg Asn Gln Ile Asn Ala Leu Thr Ser Phe 
        275                 280                 285             


Val Asp Ala Ser Met Val Tyr Gly Ser Glu Glu Pro Leu Ala Arg Asn 
    290                 295                 300                 


Leu Arg Asn Met Ser Asn Gln Leu Gly Leu Leu Ala Val Asn Gln Arg 
305                 310                 315                 320 


Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp Asn Leu His Asp 
                325                 330                 335     


Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile Pro Cys Phe Leu 
            340                 345                 350         


Ala Gly Asp Thr Arg Ser Ser Glu Met Pro Glu Leu Thr Ser Met His 
        355                 360                 365             


Thr Leu Leu Leu Arg Glu His Asn Arg Leu Ala Thr Glu Leu Lys Ser 
    370                 375                 380                 


Leu Asn Pro Arg Trp Asp Gly Glu Arg Leu Tyr Gln Glu Ala Arg Lys 
385                 390                 395                 400 


Ile Val Gly Ala Met Val Gln Ile Ile Thr Tyr Arg Asp Tyr Leu Pro 
                405                 410                 415     


Leu Val Leu Gly Pro Thr Ala Met Arg Lys Tyr Leu Pro Thr Tyr Arg 
            420                 425                 430         


Ser Tyr Asn Asp Ser Val Asp Pro Arg Ile Ala Asn Val Phe Thr Asn 
        435                 440                 445             


Ala Phe Arg Tyr Gly His Thr Leu Ile Gln Pro Phe Met Phe Arg Leu 
    450                 455                 460                 


Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val Pro Leu Ser 
465                 470                 475                 480 


Arg Val Phe Phe Ala Ser Trp Arg Val Val Leu Glu Gly Gly Ile Asp 
                485                 490                 495     


Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys Leu Asn Arg Gln 
            500                 505                 510         


Asn Gln Ile Ala Val Asp Glu Ile Arg Glu Arg Leu Phe Glu Gln Val 
        515                 520                 525             


Met Arg Ile Gly Leu Asp Leu Pro Ala Leu Asn Met Gln Arg Ser Arg 
    530                 535                 540                 


Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg Phe Cys Gly Leu 
545                 550                 555                 560 


Pro Gln Pro Glu Thr Val Gly Gln Leu Gly Thr Val Leu Arg Asn Leu 
                565                 570                 575     


Lys Leu Ala Arg Lys Leu Met Glu Gln Tyr Gly Thr Pro Asn Asn Ile 
            580                 585                 590         


Asp Ile Trp Met Gly Gly Val Ser Glu Pro Leu Lys Arg Lys Gly Arg 
        595                 600                 605             


Val Gly Pro Leu Leu Ala Cys Ile Ile Gly Thr Gln Phe Arg Lys Leu 
    610                 615                 620                 


Arg Asp Gly Asp Arg Phe Trp Trp Glu Asn Glu Gly Val Phe Ser Met 
625                 630                 635                 640 


Gln Gln Arg Gln Ala Leu Ala Gln Ile Ser Leu Pro Arg Ile Ile Cys 
                645                 650                 655     


Asp Asn Thr Gly Ile Thr Thr Val Ser Lys Asn Asn Ile Phe Met Ser 
            660                 665                 670         


Asn Ser Tyr Pro Arg Asp Phe Val Asn Cys Ser Thr Leu Pro Ala Leu 
        675                 680                 685             


Asn Leu Ala Ser Trp Arg Glu Ala Ser 
    690                 695         


<210>  12
<211>  398
<212>  PRT
<213>  HOMO SAPIENS

<400>  12

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val 
305                 310                 315                 320 


Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Ala Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  13
<211>  507
<212>  PRT
<213>  HOMO SAPIENS

<400>  13

Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr Ser Asp Gln Arg Tyr Val 
1               5                   10                  15      


Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr Asp Val Ser Ser Ala Ala 
            20                  25                  30          


Gln Pro Gly Cys Ser Val Leu Asp Glu Ala Phe Gln Arg Tyr Arg Asp 
        35                  40                  45              


Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg Pro Tyr Leu Thr Gly Lys 
    50                  55                  60                  


Arg His Thr Leu Glu Lys Asn Val Leu Val Val Ser Val Val Thr Pro 
65                  70                  75                  80  


Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser Val Glu Asn Tyr Thr Leu 
                85                  90                  95      


Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu Ser Glu Thr Val Trp Gly 
            100                 105                 110         


Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln Leu Val Trp Lys Ser Ala 
        115                 120                 125             


Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu Ile Glu Asp Phe Pro Arg 
    130                 135                 140                 


Phe Pro His Arg Gly Leu Leu Leu Asp Thr Ser Arg His Tyr Leu Pro 
145                 150                 155                 160 


Leu Ser Ser Ile Leu Asp Thr Leu Asp Val Met Ala Tyr Asn Lys Leu 
                165                 170                 175     


Asn Val Phe His Trp His Leu Val Asp Asp Pro Ser Phe Pro Tyr Glu 
            180                 185                 190         


Ser Phe Thr Phe Pro Glu Leu Met Arg Lys Gly Ser Tyr Asn Pro Val 
        195                 200                 205             


Thr His Ile Tyr Thr Ala Gln Asp Val Lys Glu Val Ile Glu Tyr Ala 
    210                 215                 220                 


Arg Leu Arg Gly Ile Arg Val Leu Ala Glu Phe Asp Thr Pro Gly His 
225                 230                 235                 240 


Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly Leu Leu Thr Pro Cys Tyr 
                245                 250                 255     


Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly Pro Val Asn Pro Ser Leu 
            260                 265                 270         


Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe Phe Leu Glu Val Ser Ser 
        275                 280                 285             


Val Phe Pro Asp Phe Tyr Leu His Leu Gly Gly Asp Glu Val Asp Phe 
    290                 295                 300                 


Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln Asp Phe Met Arg Lys Lys 
305                 310                 315                 320 


Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu Ser Phe Tyr Ile Gln Thr 
                325                 330                 335     


Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys Gly Tyr Val Val Trp Gln 
            340                 345                 350         


Glu Val Phe Asp Asn Lys Val Lys Ile Gln Pro Asp Thr Ile Ile Gln 
        355                 360                 365             


Val Trp Arg Glu Asp Ile Pro Val Asn Tyr Met Lys Glu Leu Glu Leu 
    370                 375                 380                 


Val Thr Lys Ala Gly Phe Arg Ala Leu Leu Ser Ala Pro Trp Tyr Leu 
385                 390                 395                 400 


Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys Asp Phe Tyr Ile Val Glu 
                405                 410                 415     


Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln Lys Ala Leu Val Ile Gly 
            420                 425                 430         


Gly Glu Ala Cys Met Trp Gly Glu Tyr Val Asp Asn Thr Asn Leu Val 
        435                 440                 445             


Pro Arg Leu Trp Pro Arg Ala Gly Ala Val Ala Glu Arg Leu Trp Ser 
    450                 455                 460                 


Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala Tyr Glu Arg Leu Ser His 
465                 470                 475                 480 


Phe Arg Cys Glu Leu Leu Arg Arg Gly Val Gln Ala Gln Pro Leu Asn 
                485                 490                 495     


Val Gly Phe Cys Glu Gln Glu Phe Glu Gln Thr 
            500                 505         


<210>  14
<211>  394
<212>  PRT
<213>  HOMO SAPIENS

<400>  14

Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile Arg Arg 
1               5                   10                  15      


Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala Lys Gly 
            20                  25                  30          


Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu Gly Pro 
        35                  40                  45              


Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr Gly Glu 
    50                  55                  60                  


Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe Asp Thr 
65                  70                  75                  80  


Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu Leu Asp 
                85                  90                  95      


Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser Ser Thr 
            100                 105                 110         


Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser Gly Ser 
        115                 120                 125             


Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys Gln Ser 
    130                 135                 140                 


Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg Gln Val 
145                 150                 155                 160 


Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala Ala Lys 
                165                 170                 175     


Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val Asn Asn 
            180                 185                 190         


Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val Asp Gln 
        195                 200                 205             


Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln Pro Gly 
    210                 215                 220                 


Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys Gly Ser 
225                 230                 235                 240 


Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val His Leu 
                245                 250                 255     


Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu Gly Cys 
            260                 265                 270         


Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro Val Asp 
        275                 280                 285             


Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu Ile Gln 
    290                 295                 300                 


Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro Ala Ile 
305                 310                 315                 320 


Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu Asp Tyr 
                325                 330                 335     


Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser Gly Phe 
            340                 345                 350         


Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile Leu Gly 
        355                 360                 365             


Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp Asn Asn 
    370                 375                 380                 


Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
385                 390                 


<210>  15
<211>  508
<212>  PRT
<213>  HOMO SAPIENS

<400>  15

Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
1               5                   10                  15      


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
            20                  25                  30          


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
        35                  40                  45              


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
    50                  55                  60                  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
65                  70                  75                  80  


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
                85                  90                  95      


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
            100                 105                 110         


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
        115                 120                 125             


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
    130                 135                 140                 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
145                 150                 155                 160 


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
                165                 170                 175     


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
            180                 185                 190         


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
        195                 200                 205             


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
    210                 215                 220                 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
225                 230                 235                 240 


Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp 
                245                 250                 255     


Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala 
            260                 265                 270         


Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys 
        275                 280                 285             


His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe 
    290                 295                 300                 


Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys 
305                 310                 315                 320 


Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser 
                325                 330                 335     


Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile 
            340                 345                 350         


Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met 
        355                 360                 365             


Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val 
    370                 375                 380                 


Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val 
385                 390                 395                 400 


Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile 
                405                 410                 415     


Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln 
            420                 425                 430         


Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu 
        435                 440                 445             


Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly 
    450                 455                 460                 


Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile 
465                 470                 475                 480 


Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys 
                485                 490                 495     


Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
            500                 505             


<210>  16
<211>  514
<212>  PRT
<213>  HOMO SAPIENS

<400>  16

Ala Arg Ala Pro Ser Val Ser Ala Lys Pro Gly Pro Ala Leu Trp Pro 
1               5                   10                  15      


Leu Pro Leu Ser Val Lys Met Thr Pro Asn Leu Leu His Leu Ala Pro 
            20                  25                  30          


Glu Asn Phe Tyr Ile Ser His Ser Pro Asn Ser Thr Ala Gly Pro Ser 
        35                  40                  45              


Cys Thr Leu Leu Glu Glu Ala Phe Arg Arg Tyr His Gly Tyr Ile Phe 
    50                  55                  60                  


Gly Phe Tyr Lys Trp His His Glu Pro Ala Glu Phe Gln Ala Lys Thr 
65                  70                  75                  80  


Gln Val Gln Gln Leu Leu Val Ser Ile Thr Leu Gln Ser Glu Cys Asp 
                85                  90                  95      


Ala Phe Pro Asn Ile Ser Ser Asp Glu Ser Tyr Thr Leu Leu Val Lys 
            100                 105                 110         


Glu Pro Val Ala Val Leu Lys Ala Asn Arg Val Trp Gly Ala Leu Arg 
        115                 120                 125             


Gly Leu Glu Thr Phe Ser Gln Leu Val Tyr Gln Asp Ser Tyr Gly Thr 
    130                 135                 140                 


Phe Thr Ile Asn Glu Ser Thr Ile Ile Asp Ser Pro Arg Phe Ser His 
145                 150                 155                 160 


Arg Gly Ile Leu Ile Asp Thr Ser Arg His Tyr Leu Pro Val Lys Ile 
                165                 170                 175     


Ile Leu Lys Thr Leu Asp Ala Met Ala Phe Asn Lys Phe Asn Val Leu 
            180                 185                 190         


His Trp His Ile Val Asp Asp Gln Ser Phe Pro Tyr Gln Ser Ile Thr 
        195                 200                 205             


Phe Pro Glu Leu Ser Asn Lys Gly Ser Tyr Ser Leu Ser His Val Tyr 
    210                 215                 220                 


Thr Pro Asn Asp Val Arg Met Val Ile Glu Tyr Ala Arg Leu Arg Gly 
225                 230                 235                 240 


Ile Arg Val Leu Pro Glu Phe Asp Thr Pro Gly His Thr Leu Ser Trp 
                245                 250                 255     


Gly Lys Gly Gln Lys Asp Leu Leu Thr Pro Cys Tyr Ser Arg Gln Asn 
            260                 265                 270         


Lys Leu Asp Ser Phe Gly Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr 
        275                 280                 285             


Ser Phe Leu Thr Thr Phe Phe Lys Glu Ile Ser Glu Val Phe Pro Asp 
    290                 295                 300                 


Gln Phe Ile His Leu Gly Gly Asp Glu Val Glu Phe Lys Cys Trp Glu 
305                 310                 315                 320 


Ser Asn Pro Lys Ile Gln Asp Phe Met Arg Gln Lys Gly Phe Gly Thr 
                325                 330                 335     


Asp Phe Lys Lys Leu Glu Ser Phe Tyr Ile Gln Lys Val Leu Asp Ile 
            340                 345                 350         


Ile Ala Thr Ile Asn Lys Gly Ser Ile Val Trp Gln Glu Val Phe Asp 
        355                 360                 365             


Asp Lys Ala Lys Leu Ala Pro Gly Thr Ile Val Glu Val Trp Lys Asp 
    370                 375                 380                 


Ser Ala Tyr Pro Glu Glu Leu Ser Arg Val Thr Ala Ser Gly Phe Pro 
385                 390                 395                 400 


Val Ile Leu Ser Ala Pro Trp Tyr Leu Asp Leu Ile Ser Tyr Gly Gln 
                405                 410                 415     


Asp Trp Arg Lys Tyr Tyr Lys Val Glu Pro Leu Asp Phe Gly Gly Thr 
            420                 425                 430         


Gln Lys Gln Lys Gln Leu Phe Ile Gly Gly Glu Ala Cys Leu Trp Gly 
        435                 440                 445             


Glu Tyr Val Asp Ala Thr Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala 
    450                 455                 460                 


Ser Ala Val Gly Glu Arg Leu Trp Ser Ser Lys Asp Val Arg Asp Met 
465                 470                 475                 480 


Asp Asp Ala Tyr Asp Arg Leu Thr Arg His Arg Cys Arg Met Val Glu 
                485                 490                 495     


Arg Gly Ile Ala Ala Gln Pro Leu Tyr Ala Gly Tyr Cys Asn His Glu 
            500                 505                 510         


Asn Met 
        


<210>  17
<211>  316
<212>  PRT
<213>  HOMO SAPIENS

<400>  17

Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp Lys 
1               5                   10                  15      


Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg Arg 
            20                  25                  30          


Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln Glu 
        35                  40                  45              


Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe Gly 
    50                  55                  60                  


Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln Asn 
65                  70                  75                  80  


Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr Glu 
                85                  90                  95      


Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro Val 
            100                 105                 110         


Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr Gly 
        115                 120                 125             


Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser Leu 
    130                 135                 140                 


Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu Gly 
145                 150                 155                 160 


Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp Asn 
                165                 170                 175     


Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu Glu 
            180                 185                 190         


Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly Phe 
        195                 200                 205             


Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala Thr 
    210                 215                 220                 


Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe Leu 
225                 230                 235                 240 


Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu Asp 
                245                 250                 255     


Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr Glu 
            260                 265                 270         


Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu Glu 
        275                 280                 285             


Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn His 
    290                 295                 300                 


Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
305                 310                 315     


<210>  18
<211>  322
<212>  PRT
<213>  HOMO SAPIENS

<400>  18

Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn Tyr 
1               5                   10                  15      


Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr Asn 
            20                  25                  30          


Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly Gly 
        35                  40                  45              


Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu Pro 
    50                  55                  60                  


Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile Lys 
65                  70                  75                  80  


Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly Ala 
                85                  90                  95      


Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His Val 
            100                 105                 110         


Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser Met 
        115                 120                 125             


Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn Phe 
    130                 135                 140                 


Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His Val 
145                 150                 155                 160 


Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn Gly 
                165                 170                 175     


Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser Lys 
            180                 185                 190         


Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His Tyr 
        195                 200                 205             


Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met Ala 
    210                 215                 220                 


Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr Ser 
225                 230                 235                 240 


Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly Glu 
                245                 250                 255     


Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu Asn 
            260                 265                 270         


Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp Gly 
        275                 280                 285             


Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly Ile 
    290                 295                 300                 


Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp Glu 
305                 310                 315                 320 


Lys Ile 
        


<210>  19
<211>  629
<212>  PRT
<213>  HOMO SAPIENS

<400>  19

Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu Ser Pro Ser Arg Glu Cys 
1               5                   10                  15      


Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg Ala Asp Phe Ser Asp Asn 
            20                  25                  30          


Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr Arg Arg Pro Leu Trp Glu 
        35                  40                  45              


Ser Gly Pro Thr Val Asp Met Pro Val Pro Ser Ser Phe Asn Asp Ile 
    50                  55                  60                  


Ser Gln Asp Trp Arg Leu Arg His Phe Val Gly Trp Val Trp Tyr Glu 
65                  70                  75                  80  


Arg Glu Val Ile Leu Pro Glu Arg Trp Thr Gln Asp Leu Arg Thr Arg 
                85                  90                  95      


Val Val Leu Arg Ile Gly Ser Ala His Ser Tyr Ala Ile Val Trp Val 
            100                 105                 110         


Asn Gly Val Asp Thr Leu Glu His Glu Gly Gly Tyr Leu Pro Phe Glu 
        115                 120                 125             


Ala Asp Ile Ser Asn Leu Val Gln Val Gly Pro Leu Pro Ser Arg Leu 
    130                 135                 140                 


Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu Thr Pro Thr Thr Leu Pro 
145                 150                 155                 160 


Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr Ser Lys Tyr Pro Lys Gly 
                165                 170                 175     


Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe Phe Asn Tyr Ala Gly Leu 
            180                 185                 190         


Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro Thr Thr Tyr Ile Asp Asp 
        195                 200                 205             


Ile Thr Val Thr Thr Ser Val Glu Gln Asp Ser Gly Leu Val Asn Tyr 
    210                 215                 220                 


Gln Ile Ser Val Lys Gly Ser Asn Leu Phe Lys Leu Glu Val Arg Leu 
225                 230                 235                 240 


Leu Asp Ala Glu Asn Lys Val Val Ala Asn Gly Thr Gly Thr Gln Gly 
                245                 250                 255     


Gln Leu Lys Val Pro Gly Val Ser Leu Trp Trp Pro Tyr Leu Met His 
            260                 265                 270         


Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu Val Gln Leu Thr Ala Gln 
        275                 280                 285             


Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr Thr Leu Pro Val Gly Ile 
    290                 295                 300                 


Arg Thr Val Ala Val Thr Lys Ser Gln Phe Leu Ile Asn Gly Lys Pro 
305                 310                 315                 320 


Phe Tyr Phe His Gly Val Asn Lys His Glu Asp Ala Asp Ile Arg Gly 
                325                 330                 335     


Lys Gly Phe Asp Trp Pro Leu Leu Val Lys Asp Phe Asn Leu Leu Arg 
            340                 345                 350         


Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser His Tyr Pro Tyr Ala Glu 
        355                 360                 365             


Glu Val Met Gln Met Cys Asp Arg Tyr Gly Ile Val Val Ile Asp Glu 
    370                 375                 380                 


Cys Pro Gly Val Gly Leu Ala Leu Pro Gln Phe Phe Asn Asn Val Ser 
385                 390                 395                 400 


Leu His His His Met Gln Val Met Glu Glu Val Val Arg Arg Asp Lys 
                405                 410                 415     


Asn His Pro Ala Val Val Met Trp Ser Val Ala Asn Glu Pro Ala Ser 
            420                 425                 430         


His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys Met Val Ile Ala His Thr 
        435                 440                 445             


Lys Ser Leu Asp Pro Ser Arg Pro Val Thr Phe Val Ser Asn Ser Asn 
    450                 455                 460                 


Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val Asp Val Ile Cys Leu Asn 
465                 470                 475                 480 


Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly His Leu Glu Leu Ile Gln 
                485                 490                 495     


Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp Tyr Lys Lys Tyr Gln Lys 
            500                 505                 510         


Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu Thr Ile Ala Gly Phe His 
        515                 520                 525             


Gln Asp Pro Pro Leu Met Phe Thr Glu Glu Tyr Gln Lys Ser Leu Leu 
    530                 535                 540                 


Glu Gln Tyr His Leu Gly Leu Asp Gln Lys Arg Arg Lys Tyr Val Val 
545                 550                 555                 560 


Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe Met Thr Glu Gln Ser Pro 
                565                 570                 575     


Thr Arg Val Leu Gly Asn Lys Lys Gly Ile Phe Thr Arg Gln Arg Gln 
            580                 585                 590         


Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu Arg Tyr Trp Lys Ile Ala 
        595                 600                 605             


Asn Glu Thr Arg Tyr Pro His Ser Val Ala Lys Ser Gln Cys Leu Glu 
    610                 615                 620                 


Asn Ser Leu Phe Thr 
625                 


<210>  20
<211>  313
<212>  PRT
<213>  HOMO SAPIENS

<400>  20

Ala Glu Leu Cys Val Asn Ser Leu Glu Lys Phe His Phe Lys Ser Trp 
1               5                   10                  15      


Met Ser Lys His Arg Lys Thr Tyr Ser Thr Glu Glu Tyr His His Arg 
            20                  25                  30          


Leu Gln Thr Phe Ala Ser Asn Trp Arg Lys Ile Asn Ala His Asn Asn 
        35                  40                  45              


Gly Asn His Thr Phe Lys Met Ala Leu Asn Gln Phe Ser Asp Met Ser 
    50                  55                  60                  


Phe Ala Glu Ile Lys His Lys Tyr Leu Trp Ser Glu Pro Gln Asn Cys 
65                  70                  75                  80  


Ser Ala Thr Lys Ser Asn Tyr Leu Arg Gly Thr Gly Pro Tyr Pro Pro 
                85                  90                  95      


Ser Val Asp Trp Arg Lys Lys Gly Asn Phe Val Ser Pro Val Lys Asn 
            100                 105                 110         


Gln Gly Ala Cys Gly Ser Cys Trp Thr Phe Ser Thr Thr Gly Ala Leu 
        115                 120                 125             


Glu Ser Ala Ile Ala Ile Ala Thr Gly Lys Met Leu Ser Leu Ala Glu 
    130                 135                 140                 


Gln Gln Leu Val Asp Cys Ala Gln Asp Phe Asn Asn His Gly Cys Gln 
145                 150                 155                 160 


Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr Ile Leu Tyr Asn Lys Gly 
                165                 170                 175     


Ile Met Gly Glu Asp Thr Tyr Pro Tyr Gln Gly Lys Asp Gly Tyr Cys 
            180                 185                 190         


Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe Val Lys Asp Val Ala Asn 
        195                 200                 205             


Ile Thr Ile Tyr Asp Glu Glu Ala Met Val Glu Ala Val Ala Leu Tyr 
    210                 215                 220                 


Asn Pro Val Ser Phe Ala Phe Glu Val Thr Gln Asp Phe Met Met Tyr 
225                 230                 235                 240 


Arg Thr Gly Ile Tyr Ser Ser Thr Ser Cys His Lys Thr Pro Asp Lys 
                245                 250                 255     


Val Asn His Ala Val Leu Ala Val Gly Tyr Gly Glu Lys Asn Gly Ile 
            260                 265                 270         


Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly Pro Gln Trp Gly Met Asn 
        275                 280                 285             


Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn Met Cys Gly Leu Ala Ala 
    290                 295                 300                 


Cys Ala Ser Tyr Pro Ile Pro Leu Val 
305                 310             


<210>  21
<211>  134
<212>  PRT
<213>  HOMO SAPIENS

<400>  21

Lys Pro Pro Gln Phe Thr Trp Ala Gln Trp Phe Glu Thr Gln His Ile 
1               5                   10                  15      


Asn Met Thr Ser Gln Gln Cys Thr Asn Ala Met Gln Val Ile Asn Asn 
            20                  25                  30          


Tyr Gln Arg Arg Cys Lys Asn Gln Asn Thr Phe Leu Leu Thr Thr Phe 
        35                  40                  45              


Ala Asn Val Val Asn Val Cys Gly Asn Pro Asn Met Thr Cys Pro Ser 
    50                  55                  60                  


Asn Lys Thr Arg Lys Asn Cys His His Ser Gly Ser Gln Val Pro Leu 
65                  70                  75                  80  


Ile His Cys Asn Leu Thr Thr Pro Ser Pro Gln Asn Ile Ser Asn Cys 
                85                  90                  95      


Arg Tyr Ala Gln Thr Pro Ala Asn Met Phe Tyr Ile Val Ala Cys Asp 
            100                 105                 110         


Asn Arg Asp Gln Arg Arg Asp Pro Pro Gln Tyr Pro Val Val Pro Val 
        115                 120                 125             


His Leu Asp Arg Ile Ile 
    130                 


<210>  22
<211>  925
<212>  PRT
<213>  HOMO SAPIENS

<400>  22

Gly His Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser 
1               5                   10                  15      


Gly Ser Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly 
            20                  25                  30          


Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro 
        35                  40                  45              


Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp 
    50                  55                  60                  


Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly 
65                  70                  75                  80  


Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly 
                85                  90                  95      


Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu 
            100                 105                 110         


Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr 
        115                 120                 125             


Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val 
    130                 135                 140                 


Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala 
145                 150                 155                 160 


Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg 
                165                 170                 175     


Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly 
            180                 185                 190         


Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr 
        195                 200                 205             


Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser 
    210                 215                 220                 


Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu 
225                 230                 235                 240 


Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu 
                245                 250                 255     


Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu 
            260                 265                 270         


Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser 
        275                 280                 285             


Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg 
    290                 295                 300                 


Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro 
305                 310                 315                 320 


Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met 
                325                 330                 335     


Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser 
            340                 345                 350         


Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His 
        355                 360                 365             


Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg 
    370                 375                 380                 


Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met 
385                 390                 395                 400 


Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp 
                405                 410                 415     


Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp 
            420                 425                 430         


Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro 
        435                 440                 445             


Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr 
    450                 455                 460                 


Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His 
465                 470                 475                 480 


Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser 
                485                 490                 495     


Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu 
            500                 505                 510         


Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala 
        515                 520                 525             


Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu 
    530                 535                 540                 


His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu 
545                 550                 555                 560 


Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe 
                565                 570                 575     


Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser 
            580                 585                 590         


Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn 
        595                 600                 605             


Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly 
    610                 615                 620                 


Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe 
625                 630                 635                 640 


Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu 
                645                 650                 655     


Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu 
            660                 665                 670         


Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln 
        675                 680                 685             


Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe 
    690                 695                 700                 


Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly 
705                 710                 715                 720 


Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val 
                725                 730                 735     


Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro 
            740                 745                 750         


Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu 
        755                 760                 765             


Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu 
    770                 775                 780                 


Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln 
785                 790                 795                 800 


Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu 
                805                 810                 815     


Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp 
            820                 825                 830         


Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln 
        835                 840                 845             


Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg 
    850                 855                 860                 


Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu 
865                 870                 875                 880 


Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val 
                885                 890                 895     


Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val 
            900                 905                 910         


Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
        915                 920                 925 


<210>  23
<211>  452
<212>  PRT
<213>  HOMO SAPIENS

<400>  23

Ala Pro Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln 
1               5                   10                  15      


Pro Ser Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys 
            20                  25                  30          


His Leu His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser 
        35                  40                  45              


Pro Val Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp 
    50                  55                  60                  


Gly Leu Leu Thr Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val 
65                  70                  75                  80  


Thr Leu Glu Tyr Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu 
                85                  90                  95      


Tyr Leu Glu Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys 
            100                 105                 110         


Phe Tyr Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala 
        115                 120                 125             


Leu Gln Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu 
    130                 135                 140                 


Phe Leu Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala 
145                 150                 155                 160 


Val Leu Val Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val 
                165                 170                 175     


Gly Asn Gly Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr 
            180                 185                 190         


Phe Ala Tyr Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu 
        195                 200                 205             


Gln Thr His Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys 
    210                 215                 220                 


Asp Leu Glu Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly 
225                 230                 235                 240 


Asn Ser Gly Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly 
                245                 250                 255     


Val Pro Ser His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp 
            260                 265                 270         


Leu Gly Asn Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln 
        275                 280                 285             


Ala Leu Leu Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr 
    290                 295                 300                 


Asn Thr Thr Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys 
305                 310                 315                 320 


Ala Leu Asn Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe 
                325                 330                 335     


Leu Val Asn Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln 
            340                 345                 350         


Tyr Leu Lys Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn 
        355                 360                 365             


Gly Asp Val Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val 
    370                 375                 380                 


Asp Ser Leu Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val 
385                 390                 395                 400 


Lys Tyr Gly Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe 
                405                 410                 415     


Ser His Ile Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro 
            420                 425                 430         


Thr Asp Lys Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn 
        435                 440                 445             


Lys Gln Pro Tyr 
    450         


<210>  24
<211>  224
<212>  PRT
<213>  HOMO SAPIENS

<400>  24

Ser Pro Leu Gln Ala Leu Asp Phe Phe Gly Asn Gly Pro Pro Val Asn 
1               5                   10                  15      


Tyr Lys Thr Gly Asn Leu Tyr Leu Arg Gly Pro Leu Lys Lys Ser Asn 
            20                  25                  30          


Ala Pro Leu Val Asn Val Thr Leu Tyr Tyr Glu Ala Leu Cys Gly Gly 
        35                  40                  45              


Cys Arg Ala Phe Leu Ile Arg Glu Leu Phe Pro Thr Trp Leu Leu Val 
    50                  55                  60                  


Met Glu Ile Leu Asn Val Thr Leu Val Pro Tyr Gly Asn Ala Gln Glu 
65                  70                  75                  80  


Gln Asn Val Ser Gly Arg Trp Glu Phe Lys Cys Gln His Gly Glu Glu 
                85                  90                  95      


Glu Cys Lys Phe Asn Lys Val Glu Ala Cys Val Leu Asp Glu Leu Asp 
            100                 105                 110         


Met Glu Leu Ala Phe Leu Thr Ile Val Cys Met Glu Glu Phe Glu Asp 
        115                 120                 125             


Met Glu Arg Ser Leu Pro Leu Cys Leu Gln Leu Tyr Ala Pro Gly Leu 
    130                 135                 140                 


Ser Pro Asp Thr Ile Met Glu Cys Ala Met Gly Asp Arg Gly Met Gln 
145                 150                 155                 160 


Leu Met His Ala Asn Ala Gln Arg Thr Asp Ala Leu Gln Pro Pro His 
                165                 170                 175     


Glu Tyr Val Pro Trp Val Thr Val Asn Gly Lys Pro Leu Glu Asp Gln 
            180                 185                 190         


Thr Gln Leu Leu Thr Leu Val Cys Gln Leu Tyr Gln Gly Lys Lys Pro 
        195                 200                 205             


Asp Val Cys Pro Ser Ser Thr Ser Ser Leu Arg Ser Val Cys Phe Lys 
    210                 215                 220                 


<210>  25
<211>  304
<212>  PRT
<213>  HOMO SAPIENS

<400>  25

Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly Asp Trp Gly Gly Val 
1               5                   10                  15      


Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met Ala Asn Ala Lys Glu 
            20                  25                  30          


Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp Phe Ile Leu Ser Leu 
        35                  40                  45              


Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp Ile Asn Asp Lys Arg 
    50                  55                  60                  


Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp Arg Ser Leu Arg Lys 
65                  70                  75                  80  


Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp His Leu Gly Asn Val 
                85                  90                  95      


Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys Arg Trp Asn Phe Pro 
            100                 105                 110         


Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro Gln Thr Asn Val Ser 
        115                 120                 125             


Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu Cys Gly Asn Ser Asp 
    130                 135                 140                 


Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg Asp Val Lys Leu Ala 
145                 150                 155                 160 


Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu Ala Ala Ala Arg Glu 
                165                 170                 175     


Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val Trp Ser Ile Ala Glu 
            180                 185                 190         


His Gly Pro Thr His Cys Leu Val Lys Gln Leu Arg Pro Leu Leu Ala 
        195                 200                 205             


Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His Asp His Asn Leu Gln 
    210                 215                 220                 


Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val Leu Ser Gly Ala Gly 
225                 230                 235                 240 


Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg Lys Val Pro Asn Gly 
                245                 250                 255     


Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser Leu Gly Gly Phe Ala 
            260                 265                 270         


Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val Thr Tyr Ile Glu Ala 
        275                 280                 285             


Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro Arg Arg Ala Arg Pro 
    290                 295                 300                 


<210>  26
<211>  489
<212>  PRT
<213>  HOMO SAPIENS

<400>  26

Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp Leu Gly Tyr Gly 
1               5                   10                  15      


Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr Pro Asn Leu Asp 
            20                  25                  30          


Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe Tyr Val Pro Val 
        35                  40                  45              


Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg Leu Pro 
    50                  55                  60                  


Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser Arg Gly 
65                  70                  75                  80  


Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala Ala Arg 
                85                  90                  95      


Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val Gly Pro 
            100                 105                 110         


Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe Leu Gly 
        115                 120                 125             


Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr Cys Phe 
    130                 135                 140                 


Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu Val Pro 
145                 150                 155                 160 


Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro Trp Leu 
                165                 170                 175     


Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu Met Ala 
            180                 185                 190         


Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala Ser His 
        195                 200                 205             


His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu Arg Ser 
    210                 215                 220                 


Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala Ala Val 
225                 230                 235                 240 


Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu Glu Thr 
                245                 250                 255     


Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg Met Ser 
            260                 265                 270         


Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr Thr Tyr 
        275                 280                 285             


Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly His Ile 
    290                 295                 300                 


Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu Leu Pro 
305                 310                 315                 320 


Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr Leu Asp 
                325                 330                 335     


Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser Pro Arg 
            340                 345                 350         


Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg Gly Val 
        355                 360                 365             


Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr Gln Gly 
    370                 375                 380                 


Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala Ser Ser 
385                 390                 395                 400 


Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser Lys Asp 
                405                 410                 415     


Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala Thr Pro 
            420                 425                 430         


Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala Gln Leu 
        435                 440                 445             


Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly Glu Asp 
    450                 455                 460                 


Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg Pro Ala 
465                 470                 475                 480 


Cys Cys His Cys Pro Asp Pro His Ala 
                485                 


<210>  27
<211>  354
<212>  PRT
<213>  HOMO SAPIENS

<400>  27

Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
1               5                   10                  15      


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
            20                  25                  30          


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
        35                  40                  45              


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
    50                  55                  60                  


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
65                  70                  75                  80  


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
                85                  90                  95      


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
            100                 105                 110         


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
        115                 120                 125             


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
    130                 135                 140                 


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
145                 150                 155                 160 


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
                165                 170                 175     


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
            180                 185                 190         


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
        195                 200                 205             


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
    210                 215                 220                 


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
225                 230                 235                 240 


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
                245                 250                 255     


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
            260                 265                 270         


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
        275                 280                 285             


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
    290                 295                 300                 


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
305                 310                 315                 320 


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
                325                 330                 335     


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
            340                 345                 350         


Thr Asp 
        


<210>  28
<211>  516
<212>  PRT
<213>  HOMO SAPIENS

<400>  28

Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn Val Val Leu Leu 
1               5                   10                  15      


Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met Thr Pro Leu Lys 
            20                  25                  30          


Lys Thr Lys Ala Leu Ile Gly Glu Met Gly Met Thr Phe Ser Ser Ala 
        35                  40                  45              


Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala Ser Ile Leu Thr 
    50                  55                  60                  


Gly Lys Tyr Pro His Asn His His Val Val Asn Asn Thr Leu Glu Gly 
65                  70                  75                  80  


Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu Pro Asn Thr Phe 
                85                  90                  95      


Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr Phe Phe Ala Gly 
            100                 105                 110         


Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly Gly Leu Glu His 
        115                 120                 125             


Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu Lys Asn Ser Lys 
    130                 135                 140                 


Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala Arg Lys His Gly 
145                 150                 155                 160 


Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu Ala Asn Val Ser 
                165                 170                 175     


Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro Phe Phe Met Met 
            180                 185                 190         


Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala Ala Pro Gln Tyr 
        195                 200                 205             


Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn Lys Asn Phe Asn 
    210                 215                 220                 


Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln Ala Lys Thr Pro 
225                 230                 235                 240 


Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala Phe Arg Lys Arg 
                245                 250                 255     


Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu Lys Leu Val Lys 
            260                 265                 270         


Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr Ile Phe Tyr Thr 
        275                 280                 285             


Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu Pro Ile Asp Lys 
    290                 295                 300                 


Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu Leu Val Arg Gly 
305                 310                 315                 320 


Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu Val Ala Asn Ile 
                325                 330                 335     


Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr Asp Leu Asn Lys 
            340                 345                 350         


Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu Arg Gly Ala Ser 
        355                 360                 365             


Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr Gln Gly Glu Gly 
    370                 375                 380                 


Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser Pro Gly Val Ser 
385                 390                 395                 400 


Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr Asn Asn Thr Tyr 
                405                 410                 415     


Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu Gln Tyr Cys Glu 
            420                 425                 430         


Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn Leu Thr Ala Asp 
        435                 440                 445             


Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp Pro Glu Leu Leu 
    450                 455                 460                 


Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser Cys Ser Gly Pro 
465                 470                 475                 480 


Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr Arg Phe Asp Pro 
                485                 490                 495     


Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr Arg Arg Phe Ser 
            500                 505                 510         


Lys His Leu Leu 
        515     


<210>  29
<211>  497
<212>  PRT
<213>  HOMO SAPIENS

<400>  29

Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val Phe Leu Leu Ala 
1               5                   10                  15      


Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly Ser Arg Ile Arg 
            20                  25                  30          


Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val Leu Leu Asp Asn 
        35                  40                  45              


Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser Gln Leu Leu Thr 
    50                  55                  60                  


Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln Ile Ile Trp Pro 
65                  70                  75                  80  


Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu Leu Pro Gln Leu 
                85                  90                  95      


Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly Lys Trp His Leu 
            100                 105                 110         


Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg Gly Phe Asp Thr 
        115                 120                 125             


Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr Ser His Glu Arg 
    130                 135                 140                 


Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys Ala Leu Asp Phe 
145                 150                 155                 160 


Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn Met Tyr Ser Thr 
                165                 170                 175     


Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr Asn His Pro Pro 
            180                 185                 190         


Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser Val His Glu Pro 
        195                 200                 205             


Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp Phe Ile Gln Asp 
    210                 215                 220                 


Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu Met Asp Glu Ala 
225                 230                 235                 240 


Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly Leu Trp Asn Asn 
                245                 250                 255     


Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln Thr Leu Ala Gly 
            260                 265                 270         


Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser Leu Trp Glu Gly 
        275                 280                 285             


Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu Leu Lys Gln Lys 
    290                 295                 300                 


Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp Trp Leu Pro Thr 
305                 310                 315                 320 


Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr Lys Pro Leu Asp 
                325                 330                 335     


Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser Pro Ser Pro Arg 
            340                 345                 350         


Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val Asp Ser Ser Pro 
        355                 360                 365             


Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp Ser Ser Leu Pro 
    370                 375                 380                 


Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala Ile Arg His Gly 
385                 390                 395                 400 


Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly Tyr Trp Phe Pro 
                405                 410                 415     


Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser Ser Asp Pro Pro 
            420                 425                 430         


Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp Pro Glu Glu Arg 
        435                 440                 445             


His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr Lys Leu Leu Ser 
    450                 455                 460                 


Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val Tyr Phe Pro Ala 
465                 470                 475                 480 


Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val Trp Gly Pro Trp 
                485                 490                 495     


Met 
    


<210>  30
<211>  654
<212>  PRT
<213>  HOMO SAPIENS

<400>  30

Leu Arg Asn Ala Thr Gln Arg Met Phe Glu Ile Asp Tyr Ser Arg Asp 
1               5                   10                  15      


Ser Phe Leu Lys Asp Gly Gln Pro Phe Arg Tyr Ile Ser Gly Ser Ile 
            20                  25                  30          


His Tyr Ser Arg Val Pro Arg Phe Tyr Trp Lys Asp Arg Leu Leu Lys 
        35                  40                  45              


Met Lys Met Ala Gly Leu Asn Ala Ile Gln Thr Tyr Val Pro Trp Asn 
    50                  55                  60                  


Phe His Glu Pro Trp Pro Gly Gln Tyr Gln Phe Ser Glu Asp His Asp 
65                  70                  75                  80  


Val Glu Tyr Phe Leu Arg Leu Ala His Glu Leu Gly Leu Leu Val Ile 
                85                  90                  95      


Leu Arg Pro Gly Pro Tyr Ile Cys Ala Glu Trp Glu Met Gly Gly Leu 
            100                 105                 110         


Pro Ala Trp Leu Leu Glu Lys Glu Ser Ile Leu Leu Arg Ser Ser Asp 
        115                 120                 125             


Pro Asp Tyr Leu Ala Ala Val Asp Lys Trp Leu Gly Val Leu Leu Pro 
    130                 135                 140                 


Lys Met Lys Pro Leu Leu Tyr Gln Asn Gly Gly Pro Val Ile Thr Val 
145                 150                 155                 160 


Gln Val Glu Asn Glu Tyr Gly Ser Tyr Phe Ala Cys Asp Phe Asp Tyr 
                165                 170                 175     


Leu Arg Phe Leu Gln Lys Arg Phe Arg His His Leu Gly Asp Asp Val 
            180                 185                 190         


Val Leu Phe Thr Thr Asp Gly Ala His Lys Thr Phe Leu Lys Cys Gly 
        195                 200                 205             


Ala Leu Gln Gly Leu Tyr Thr Thr Val Asp Phe Gly Thr Gly Ser Asn 
    210                 215                 220                 


Ile Thr Asp Ala Phe Leu Ser Gln Arg Lys Cys Glu Pro Lys Gly Pro 
225                 230                 235                 240 


Leu Ile Asn Ser Glu Phe Tyr Thr Gly Trp Leu Asp His Trp Gly Gln 
                245                 250                 255     


Pro His Ser Thr Ile Lys Thr Glu Ala Val Ala Ser Ser Leu Tyr Asp 
            260                 265                 270         


Ile Leu Ala Arg Gly Ala Ser Val Asn Leu Tyr Met Phe Ile Gly Gly 
        275                 280                 285             


Thr Asn Phe Ala Tyr Trp Asn Gly Ala Asn Ser Pro Tyr Ala Ala Gln 
    290                 295                 300                 


Pro Thr Ser Tyr Asp Tyr Asp Ala Pro Leu Ser Glu Ala Gly Asp Leu 
305                 310                 315                 320 


Thr Glu Lys Tyr Phe Ala Leu Arg Asn Ile Ile Gln Lys Phe Glu Lys 
                325                 330                 335     


Val Pro Glu Gly Pro Ile Pro Pro Ser Thr Pro Lys Phe Ala Tyr Gly 
            340                 345                 350         


Lys Val Thr Leu Glu Lys Leu Lys Thr Val Gly Ala Ala Leu Asp Ile 
        355                 360                 365             


Leu Cys Pro Ser Gly Pro Ile Lys Ser Leu Tyr Pro Leu Thr Phe Ile 
    370                 375                 380                 


Gln Val Lys Gln His Tyr Gly Phe Val Leu Tyr Arg Thr Thr Leu Pro 
385                 390                 395                 400 


Gln Asp Cys Ser Asn Pro Ala Pro Leu Ser Ser Pro Leu Asn Gly Val 
                405                 410                 415     


His Asp Arg Ala Tyr Val Ala Val Asp Gly Ile Pro Gln Gly Val Leu 
            420                 425                 430         


Glu Arg Asn Asn Val Ile Thr Leu Asn Ile Thr Gly Lys Ala Gly Ala 
        435                 440                 445             


Thr Leu Asp Leu Leu Val Glu Asn Met Gly Arg Val Asn Tyr Gly Ala 
    450                 455                 460                 


Tyr Ile Asn Asp Phe Lys Gly Leu Val Ser Asn Leu Thr Leu Ser Ser 
465                 470                 475                 480 


Asn Ile Leu Thr Asp Trp Thr Ile Phe Pro Leu Asp Thr Glu Asp Ala 
                485                 490                 495     


Val Arg Ser His Leu Gly Gly Trp Gly His Arg Asp Ser Gly His His 
            500                 505                 510         


Asp Glu Ala Trp Ala His Asn Ser Ser Asn Tyr Thr Leu Pro Ala Phe 
        515                 520                 525             


Tyr Met Gly Asn Phe Ser Ile Pro Ser Gly Ile Pro Asp Leu Pro Gln 
    530                 535                 540                 


Asp Thr Phe Ile Gln Phe Pro Gly Trp Thr Lys Gly Gln Val Trp Ile 
545                 550                 555                 560 


Asn Gly Phe Asn Leu Gly Arg Tyr Trp Pro Ala Arg Gly Pro Gln Leu 
                565                 570                 575     


Thr Leu Phe Val Pro Gln His Ile Leu Met Thr Ser Ala Pro Asn Thr 
            580                 585                 590         


Ile Thr Val Leu Glu Leu Glu Trp Ala Pro Cys Ser Ser Asp Asp Pro 
        595                 600                 605             


Glu Leu Cys Ala Val Thr Phe Val Asp Arg Pro Val Ile Gly Ser Ser 
    610                 615                 620                 


Val Thr Tyr Asp His Pro Ser Lys Pro Val Glu Lys Arg Leu Met Pro 
625                 630                 635                 640 


Pro Pro Pro Gln Lys Asn Lys Asp Ser Trp Leu Asp His Val 
                645                 650                 


<210>  31
<211>  394
<212>  PRT
<213>  HOMO SAPIENS

<400>  31

Leu Asp Asn Gly Leu Leu Gln Thr Pro Pro Met Gly Trp Leu Ala Trp 
1               5                   10                  15      


Glu Arg Phe Arg Cys Asn Ile Asn Cys Asp Glu Asp Pro Lys Asn Cys 
            20                  25                  30          


Ile Ser Glu Gln Leu Phe Met Glu Met Ala Asp Arg Met Ala Gln Asp 
        35                  40                  45              


Gly Trp Arg Asp Met Gly Tyr Thr Tyr Leu Asn Ile Asp Asp Cys Trp 
    50                  55                  60                  


Ile Gly Gly Arg Asp Ala Ser Gly Arg Leu Met Pro Asp Pro Lys Arg 
65                  70                  75                  80  


Phe Pro His Gly Ile Pro Phe Leu Ala Asp Tyr Val His Ser Leu Gly 
                85                  90                  95      


Leu Lys Leu Gly Ile Tyr Ala Asp Met Gly Asn Phe Thr Cys Met Gly 
            100                 105                 110         


Tyr Pro Gly Thr Thr Leu Asp Lys Val Val Gln Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Glu Trp Lys Val Asp Met Leu Lys Leu Asp Gly Cys Phe Ser Thr 
    130                 135                 140                 


Pro Glu Glu Arg Ala Gln Gly Tyr Pro Lys Met Ala Ala Ala Leu Asn 
145                 150                 155                 160 


Ala Thr Gly Arg Pro Ile Ala Phe Ser Cys Ser Trp Pro Ala Tyr Glu 
                165                 170                 175     


Gly Gly Leu Pro Pro Arg Val Asn Tyr Ser Leu Leu Ala Asp Ile Cys 
            180                 185                 190         


Asn Leu Trp Arg Asn Tyr Asp Asp Ile Gln Asp Ser Trp Trp Ser Val 
        195                 200                 205             


Leu Ser Ile Leu Asn Trp Phe Val Glu His Gln Asp Ile Leu Gln Pro 
    210                 215                 220                 


Val Ala Gly Pro Gly His Trp Asn Asp Pro Asp Met Leu Leu Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Leu Glu Gln Ser Arg Ala Gln Met Ala Leu Trp 
                245                 250                 255     


Thr Val Leu Ala Ala Pro Leu Leu Met Ser Thr Asp Leu Arg Thr Ile 
            260                 265                 270         


Ser Ala Gln Asn Met Asp Ile Leu Gln Asn Pro Leu Met Ile Lys Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Ile Gln Gly Arg Arg Ile His Lys Glu Lys 
    290                 295                 300                 


Ser Leu Ile Glu Val Tyr Met Arg Pro Leu Ser Asn Lys Ala Ser Ala 
305                 310                 315                 320 


Leu Val Phe Phe Ser Cys Arg Thr Asp Met Pro Tyr Arg Tyr His Ser 
                325                 330                 335     


Ser Leu Gly Gln Leu Asn Phe Thr Gly Ser Val Ile Tyr Glu Ala Gln 
            340                 345                 350         


Asp Val Tyr Ser Gly Asp Ile Ile Ser Gly Leu Arg Asp Glu Thr Asn 
        355                 360                 365             


Phe Thr Val Ile Ile Asn Pro Ser Gly Val Val Met Trp Tyr Leu Tyr 
    370                 375                 380                 


Pro Ile Lys Asn Leu Glu Met Ser Gln Gln 
385                 390                 


<210>  32
<211>  583
<212>  PRT
<213>  HOMO SAPIENS

<400>  32

Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu 
1               5                   10                  15      


Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu 
            20                  25                  30          


Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly 
        35                  40                  45              


Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala 
    50                  55                  60                  


Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala 
65                  70                  75                  80  


Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met 
                85                  90                  95      


Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly 
            100                 105                 110         


Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp 
        115                 120                 125             


Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser 
    130                 135                 140                 


Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp 
145                 150                 155                 160 


Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala 
                165                 170                 175     


Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg 
            180                 185                 190         


Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu 
        195                 200                 205             


Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe 
    210                 215                 220                 


Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His 
225                 230                 235                 240 


Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu 
                245                 250                 255     


Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn 
            260                 265                 270         


His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly 
        275                 280                 285             


Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu 
    290                 295                 300                 


Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe 
305                 310                 315                 320 


Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met 
                325                 330                 335     


Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp 
            340                 345                 350         


Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu 
        355                 360                 365             


Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His 
    370                 375                 380                 


Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr 
385                 390                 395                 400 


Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu 
                405                 410                 415     


Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val 
            420                 425                 430         


Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly 
        435                 440                 445             


Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val 
    450                 455                 460                 


Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile 
465                 470                 475                 480 


Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr 
                485                 490                 495     


Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr 
            500                 505                 510         


Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr 
        515                 520                 525             


His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu 
    530                 535                 540                 


Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu 
545                 550                 555                 560 


Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu 
                565                 570                 575     


Trp Pro Arg Pro Leu Phe Cys 
            580             


<210>  33
<211>  170
<212>  PRT
<213>  HOMO SAPIENS

<400>  33

His Leu Lys Lys Pro Ser Gln Leu Ser Ser Phe Ser Trp Asp Asn Cys 
1               5                   10                  15      


Asp Glu Gly Lys Asp Pro Ala Val Ile Arg Ser Leu Thr Leu Glu Pro 
            20                  25                  30          


Asp Pro Ile Ile Val Pro Gly Asn Val Thr Leu Ser Val Met Gly Ser 
        35                  40                  45              


Thr Ser Val Pro Leu Ser Ser Pro Leu Lys Val Asp Leu Val Leu Glu 
    50                  55                  60                  


Lys Glu Val Ala Gly Leu Trp Ile Lys Ile Pro Cys Thr Asp Tyr Ile 
65                  70                  75                  80  


Gly Ser Cys Thr Phe Glu His Phe Cys Asp Val Leu Asp Met Leu Ile 
                85                  90                  95      


Pro Thr Gly Glu Pro Cys Pro Glu Pro Leu Arg Thr Tyr Gly Leu Pro 
            100                 105                 110         


Cys His Cys Pro Phe Lys Glu Gly Thr Tyr Ser Leu Pro Lys Ser Glu 
        115                 120                 125             


Phe Val Val Pro Asp Leu Glu Leu Pro Ser Trp Leu Thr Thr Gly Asn 
    130                 135                 140                 


Tyr Arg Ile Glu Ser Val Leu Ser Ser Ser Gly Lys Arg Leu Gly Cys 
145                 150                 155                 160 


Ile Lys Ile Ala Ala Ser Leu Lys Gly Ile 
                165                 170 


<210>  34
<211>  323
<212>  PRT
<213>  HOMO SAPIENS

<400>  34

Ser Ser Pro Leu Pro Leu Val Val Asn Thr Trp Pro Phe Lys Asn Ala 
1               5                   10                  15      


Thr Glu Ala Ala Trp Arg Ala Leu Ala Ser Gly Gly Ser Ala Leu Asp 
            20                  25                  30          


Ala Val Glu Ser Gly Cys Ala Met Cys Glu Arg Glu Gln Cys Asp Gly 
        35                  40                  45              


Ser Val Gly Phe Gly Gly Ser Pro Asp Glu Leu Gly Glu Thr Thr Leu 
    50                  55                  60                  


Asp Ala Met Ile Met Asp Gly Thr Thr Met Asp Val Gly Ala Val Gly 
65                  70                  75                  80  


Asp Leu Arg Arg Ile Lys Asn Ala Ile Gly Val Ala Arg Lys Val Leu 
                85                  90                  95      


Glu His Thr Thr His Thr Leu Leu Val Gly Glu Ser Ala Thr Thr Phe 
            100                 105                 110         


Ala Gln Ser Met Gly Phe Ile Asn Glu Asp Leu Ser Thr Thr Ala Ser 
        115                 120                 125             


Gln Ala Leu His Ser Asp Trp Leu Ala Arg Asn Cys Gln Pro Asn Tyr 
    130                 135                 140                 


Trp Arg Asn Val Ile Pro Asp Pro Ser Lys Tyr Cys Gly Pro Tyr Lys 
145                 150                 155                 160 


Pro Pro Gly Ile Leu Lys Gln Asp Ile Pro Ile His Lys Glu Thr Glu 
                165                 170                 175     


Asp Asp Arg Gly His Asp Thr Ile Gly Met Val Val Ile His Lys Thr 
            180                 185                 190         


Gly His Ile Ala Ala Gly Thr Ser Thr Asn Gly Ile Lys Phe Lys Ile 
        195                 200                 205             


His Gly Arg Val Gly Asp Ser Pro Ile Pro Gly Ala Gly Ala Tyr Ala 
    210                 215                 220                 


Asp Asp Thr Ala Gly Ala Ala Ala Ala Thr Gly Asn Gly Asp Ile Leu 
225                 230                 235                 240 


Met Arg Phe Leu Pro Ser Tyr Gln Ala Val Glu Tyr Met Arg Arg Gly 
                245                 250                 255     


Glu Asp Pro Thr Ile Ala Cys Gln Lys Val Ile Ser Arg Ile Gln Lys 
            260                 265                 270         


His Phe Pro Glu Phe Phe Gly Ala Val Ile Cys Ala Asn Val Thr Gly 
        275                 280                 285             


Ser Tyr Gly Ala Ala Cys Asn Lys Leu Ser Thr Phe Thr Gln Phe Ser 
    290                 295                 300                 


Phe Met Val Tyr Asn Ser Glu Lys Asn Gln Pro Thr Glu Glu Lys Val 
305                 310                 315                 320 


Asp Cys Ile 
            


<210>  35
<211>  525
<212>  PRT
<213>  HOMO SAPIENS

<400>  35

Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
        515                 520                 525 


<210>  36
<211>  315
<212>  PRT
<213>  HOMO SAPIENS

<400>  36

Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys 
1               5                   10                  15      


Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
            20                  25                  30          


Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
        35                  40                  45              


Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
    50                  55                  60                  


Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Met Ser Ser Leu Arg 
65                  70                  75                  80  


Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys Ser Asn Pro Asn 
                85                  90                  95      


Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr 
            100                 105                 110         


Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala 
        115                 120                 125             


Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val 
    130                 135                 140                 


Ser Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly 
145                 150                 155                 160 


Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile 
                165                 170                 175     


Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala 
            180                 185                 190         


Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys 
        195                 200                 205             


Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu 
    210                 215                 220                 


Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His 
225                 230                 235                 240 


Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys 
                245                 250                 255     


Thr Gln Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe 
        275                 280                 285             


Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys 
    290                 295                 300                 


Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
305                 310                 315 


<210>  37
<211>  496
<212>  PRT
<213>  HOMO SAPIENS

<400>  37

Ala Pro Gln Pro Pro Asn Ile Leu Leu Leu Leu Met Asp Asp Met Gly 
1               5                   10                  15      


Trp Gly Asp Leu Gly Val Tyr Gly Glu Pro Ser Arg Glu Thr Pro Asn 
            20                  25                  30          


Leu Asp Arg Met Ala Ala Glu Gly Leu Leu Phe Pro Asn Phe Tyr Ser 
        35                  40                  45              


Ala Asn Pro Leu Cys Ser Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg 
    50                  55                  60                  


Leu Pro Ile Arg Asn Gly Phe Tyr Thr Thr Asn Ala His Ala Arg Asn 
65                  70                  75                  80  


Ala Tyr Thr Pro Gln Glu Ile Val Gly Gly Ile Pro Asp Ser Glu Gln 
                85                  90                  95      


Leu Leu Pro Glu Leu Leu Lys Lys Ala Gly Tyr Val Ser Lys Ile Val 
            100                 105                 110         


Gly Lys Trp His Leu Gly His Arg Pro Gln Phe His Pro Leu Lys His 
        115                 120                 125             


Gly Phe Asp Glu Trp Phe Gly Ser Pro Asn Cys His Phe Gly Pro Tyr 
    130                 135                 140                 


Asp Asn Lys Ala Arg Pro Asn Ile Pro Val Tyr Arg Asp Trp Glu Met 
145                 150                 155                 160 


Val Gly Arg Tyr Tyr Glu Glu Phe Pro Ile Asn Leu Lys Thr Gly Glu 
                165                 170                 175     


Ala Asn Leu Thr Gln Ile Tyr Leu Gln Glu Ala Leu Asp Phe Ile Lys 
            180                 185                 190         


Arg Gln Ala Arg His His Pro Phe Phe Leu Tyr Trp Ala Val Asp Ala 
        195                 200                 205             


Thr His Ala Pro Val Tyr Ala Ser Lys Pro Phe Leu Gly Thr Ser Gln 
    210                 215                 220                 


Arg Gly Arg Tyr Gly Asp Ala Val Arg Glu Ile Asp Asp Ser Ile Gly 
225                 230                 235                 240 


Lys Ile Leu Glu Leu Leu Gln Asp Leu His Val Ala Asp Asn Thr Phe 
                245                 250                 255     


Val Phe Phe Thr Ser Asp Asn Gly Ala Ala Leu Ile Ser Ala Pro Glu 
            260                 265                 270         


Gln Gly Gly Ser Asn Gly Pro Phe Leu Cys Gly Lys Gln Thr Thr Phe 
        275                 280                 285             


Glu Gly Gly Met Arg Glu Pro Ala Leu Ala Trp Trp Pro Gly His Val 
    290                 295                 300                 


Thr Ala Gly Gln Val Ser His Gln Leu Gly Ser Ile Met Asp Leu Phe 
305                 310                 315                 320 


Thr Thr Ser Leu Ala Leu Ala Gly Leu Thr Pro Pro Ser Asp Arg Ala 
                325                 330                 335     


Ile Asp Gly Leu Asn Leu Leu Pro Thr Leu Leu Gln Gly Arg Leu Met 
            340                 345                 350         


Asp Arg Pro Ile Phe Tyr Tyr Arg Gly Asp Thr Leu Met Ala Ala Thr 
        355                 360                 365             


Leu Gly Gln His Lys Ala His Phe Trp Thr Trp Thr Asn Ser Trp Glu 
    370                 375                 380                 


Asn Phe Arg Gln Gly Ile Asp Phe Cys Pro Gly Gln Asn Val Ser Gly 
385                 390                 395                 400 


Val Thr Thr His Asn Leu Glu Asp His Thr Lys Leu Pro Leu Ile Phe 
                405                 410                 415     


His Leu Gly Arg Asp Pro Gly Glu Arg Phe Pro Leu Ser Phe Ala Ser 
            420                 425                 430         


Ala Glu Tyr Gln Glu Ala Leu Ser Arg Ile Thr Ser Val Val Gln Gln 
        435                 440                 445             


His Gln Glu Ala Leu Val Pro Ala Gln Pro Gln Leu Asn Val Cys Asn 
    450                 455                 460                 


Trp Ala Val Met Asn Trp Ala Pro Pro Gly Cys Glu Lys Leu Gly Lys 
465                 470                 475                 480 


Cys Leu Thr Pro Pro Glu Ser Ile Pro Lys Lys Cys Leu Trp Ser His 
                485                 490                 495     


<210>  38
<211>  626
<212>  PRT
<213>  HOMO SAPIENS

<400>  38

Ala Pro His Leu Val His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu 
1               5                   10                  15      


Arg Arg Phe Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser 
            20                  25                  30          


Gln Ala Asp Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala 
        35                  40                  45              


Tyr Val Gly Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr His 
    50                  55                  60                  


Trp Leu Leu Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu 
65                  70                  75                  80  


Ser Tyr Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu 
                85                  90                  95      


Asn Gln Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His 
            100                 105                 110         


Phe Thr Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu 
        115                 120                 125             


Val Ser Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His 
    130                 135                 140                 


Val Ser Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His Asp 
145                 150                 155                 160 


Phe Asp Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp 
                165                 170                 175     


Ala Cys Ser Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly 
            180                 185                 190         


Gly Pro Gly Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp 
        195                 200                 205             


Gly Leu Leu Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu 
    210                 215                 220                 


Ala Gly Val Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg 
225                 230                 235                 240 


Ser Ser Ile Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile 
                245                 250                 255     


Arg Gln Leu Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu 
            260                 265                 270         


Ala Asp Pro Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp 
        275                 280                 285             


Val Thr Tyr Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln Asn 
    290                 295                 300                 


Leu Leu Leu Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser 
305                 310                 315                 320 


Asn Asp Asn Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg 
                325                 330                 335     


Thr Leu Thr Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His Val 
            340                 345                 350         


Gln Leu Leu Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu 
        355                 360                 365             


Leu Asp Glu Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val 
    370                 375                 380                 


Leu Asp Ser Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg Pro 
385                 390                 395                 400 


Gln Gly Pro Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser 
                405                 410                 415     


Asp Asp Thr Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu Arg 
            420                 425                 430         


Leu Arg Gly Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr 
        435                 440                 445             


Leu Asp Asn Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly 
    450                 455                 460                 


Arg Pro Val Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala 
465                 470                 475                 480 


Glu Asp Pro Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg 
                485                 490                 495     


Leu Thr Leu Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His 
            500                 505                 510         


Val Cys Ala Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg 
        515                 520                 525             


Ala Leu Pro Leu Thr Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu 
    530                 535                 540                 


His Val Gly Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln 
545                 550                 555                 560 


Asp Gly Lys Ala Tyr Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn 
                565                 570                 575     


Leu Phe Val Phe Ser Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg 
            580                 585                 590         


Val Arg Ala Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro 
        595                 600                 605             


Val Pro Tyr Leu Glu Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly 
    610                 615                 620                 


Asn Pro 
625     


<210>  39
<211>  376
<212>  PRT
<213>  HOMO SAPIENS

<400>  39

Gly Lys Leu Thr Ala Val Asp Pro Glu Thr Asn Met Asn Val Ser Glu 
1               5                   10                  15      


Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr 
            20                  25                  30          


Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys 
        35                  40                  45              


Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly 
    50                  55                  60                  


Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser 
65                  70                  75                  80  


Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn 
                85                  90                  95      


Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser 
            100                 105                 110         


Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp 
        115                 120                 125             


Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln 
    130                 135                 140                 


Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala 
145                 150                 155                 160 


Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala 
                165                 170                 175     


Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys 
            180                 185                 190         


Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys 
        195                 200                 205             


Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val 
    210                 215                 220                 


Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu 
225                 230                 235                 240 


Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val 
                245                 250                 255     


Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His 
            260                 265                 270         


Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly 
        275                 280                 285             


Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr 
    290                 295                 300                 


Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly 
305                 310                 315                 320 


His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln 
                325                 330                 335     


Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu 
            340                 345                 350         


Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile 
        355                 360                 365             


Ile Asn Leu Met Arg Lys Tyr Gln 
    370                 375     


<210>  40
<211>  475
<212>  PRT
<213>  HOMO SAPIENS

<400>  40

Leu Arg Pro Ala Leu Arg Ala Leu Gly Ser Leu His Leu Pro Thr Asn 
1               5                   10                  15      


Pro Thr Ser Leu Pro Ala Val Ala Lys Asn Tyr Ser Val Leu Tyr Phe 
            20                  25                  30          


Gln Gln Lys Val Asp His Phe Gly Phe Asn Thr Val Lys Thr Phe Asn 
        35                  40                  45              


Gln Arg Tyr Leu Val Ala Asp Lys Tyr Trp Lys Lys Asn Gly Gly Ser 
    50                  55                  60                  


Ile Leu Phe Tyr Thr Gly Asn Glu Gly Asp Ile Ile Trp Phe Cys Asn 
65                  70                  75                  80  


Asn Thr Gly Phe Met Trp Asp Val Ala Glu Glu Leu Lys Ala Met Leu 
                85                  90                  95      


Val Phe Ala Glu His Arg Tyr Tyr Gly Glu Ser Leu Pro Phe Gly Asp 
            100                 105                 110         


Asn Ser Phe Lys Asp Ser Arg His Leu Asn Phe Leu Thr Ser Glu Gln 
        115                 120                 125             


Ala Leu Ala Asp Phe Ala Glu Leu Ile Lys His Leu Lys Arg Thr Ile 
    130                 135                 140                 


Pro Gly Ala Glu Asn Gln Pro Val Ile Ala Ile Gly Gly Ser Tyr Gly 
145                 150                 155                 160 


Gly Met Leu Ala Ala Trp Phe Arg Met Lys Tyr Pro His Met Val Val 
                165                 170                 175     


Gly Ala Leu Ala Ala Ser Ala Pro Ile Trp Gln Phe Glu Asp Leu Val 
            180                 185                 190         


Pro Cys Gly Val Phe Met Lys Ile Val Thr Thr Asp Phe Arg Lys Ser 
        195                 200                 205             


Gly Pro His Cys Ser Glu Ser Ile His Arg Ser Trp Asp Ala Ile Asn 
    210                 215                 220                 


Arg Leu Ser Asn Thr Gly Ser Gly Leu Gln Trp Leu Thr Gly Ala Leu 
225                 230                 235                 240 


His Leu Cys Ser Pro Leu Thr Ser Gln Asp Ile Gln His Leu Lys Asp 
                245                 250                 255     


Trp Ile Ser Glu Thr Trp Val Asn Leu Ala Met Val Asp Tyr Pro Tyr 
            260                 265                 270         


Ala Ser Asn Phe Leu Gln Pro Leu Pro Ala Trp Pro Ile Lys Val Val 
        275                 280                 285             


Cys Gln Tyr Leu Lys Asn Pro Asn Val Ser Asp Ser Leu Leu Leu Gln 
    290                 295                 300                 


Asn Ile Phe Gln Ala Leu Asn Val Tyr Tyr Asn Tyr Ser Gly Gln Val 
305                 310                 315                 320 


Lys Cys Leu Asn Ile Ser Glu Thr Ala Thr Ser Ser Leu Gly Thr Leu 
                325                 330                 335     


Gly Trp Ser Tyr Gln Ala Cys Thr Glu Val Val Met Pro Phe Cys Thr 
            340                 345                 350         


Asn Gly Val Asp Asp Met Phe Glu Pro His Ser Trp Asn Leu Lys Glu 
        355                 360                 365             


Leu Ser Asp Asp Cys Phe Gln Gln Trp Gly Val Arg Pro Arg Pro Ser 
    370                 375                 380                 


Trp Ile Thr Thr Met Tyr Gly Gly Lys Asn Ile Ser Ser His Thr Asn 
385                 390                 395                 400 


Ile Val Phe Ser Asn Gly Glu Leu Asp Pro Trp Ser Gly Gly Gly Val 
                405                 410                 415     


Thr Lys Asp Ile Thr Asp Thr Leu Val Ala Val Thr Ile Ser Glu Gly 
            420                 425                 430         


Ala His His Leu Asp Leu Arg Thr Lys Asn Ala Leu Asp Pro Met Ser 
        435                 440                 445             


Val Leu Leu Ala Arg Ser Leu Glu Val Arg His Met Lys Asn Trp Ile 
    450                 455                 460                 


Arg Asp Phe Tyr Asp Ser Ala Gly Lys Gln His 
465                 470                 475 


<210>  41
<211>  298
<212>  PRT
<213>  HOMO SAPIENS

<400>  41

Asp Ser Arg Ala Pro Phe Thr Pro Thr Trp Pro Arg Ser Arg Glu Arg 
1               5                   10                  15      


Glu Ala Ala Ala Phe Arg Glu Ser Leu Asn Arg His Arg Tyr Leu Asn 
            20                  25                  30          


Ser Leu Phe Pro Ser Glu Asn Ser Thr Ala Phe Tyr Gly Ile Asn Gln 
        35                  40                  45              


Phe Ser Tyr Leu Phe Pro Glu Glu Phe Lys Ala Ile Tyr Leu Arg Ser 
    50                  55                  60                  


Lys Pro Ser Lys Phe Pro Arg Tyr Ser Ala Glu Val His Met Ser Ile 
65                  70                  75                  80  


Pro Asn Val Ser Leu Pro Leu Arg Phe Asp Trp Arg Asp Lys Gln Val 
                85                  90                  95      


Val Thr Gln Val Arg Asn Gln Gln Met Cys Gly Gly Cys Trp Ala Phe 
            100                 105                 110         


Ser Val Val Gly Ala Val Glu Ser Ala Tyr Ala Ile Lys Gly Lys Pro 
        115                 120                 125             


Leu Glu Asp Leu Ser Val Gln Gln Val Ile Asp Cys Ser Tyr Asn Asn 
    130                 135                 140                 


Tyr Gly Cys Asn Gly Gly Ser Thr Leu Asn Ala Leu Asn Trp Leu Asn 
145                 150                 155                 160 


Lys Met Gln Val Lys Leu Val Lys Asp Ser Glu Tyr Pro Phe Lys Ala 
                165                 170                 175     


Gln Asn Gly Leu Cys His Tyr Phe Ser Gly Ser His Ser Gly Phe Ser 
            180                 185                 190         


Ile Lys Gly Tyr Ser Ala Tyr Asp Phe Ser Asp Gln Glu Asp Glu Met 
        195                 200                 205             


Ala Lys Ala Leu Leu Thr Phe Gly Pro Leu Val Val Ile Val Asp Ala 
    210                 215                 220                 


Val Ser Trp Gln Asp Tyr Leu Gly Gly Ile Ile Gln His His Cys Ser 
225                 230                 235                 240 


Ser Gly Glu Ala Asn His Ala Val Leu Ile Thr Gly Phe Asp Lys Thr 
                245                 250                 255     


Gly Ser Thr Pro Tyr Trp Ile Val Arg Asn Ser Trp Gly Ser Ser Trp 
            260                 265                 270         


Gly Val Asp Gly Tyr Ala His Val Lys Met Gly Ser Asn Val Cys Gly 
        275                 280                 285             


Ile Ala Asp Ser Val Ser Ser Ile Phe Val 
    290                 295             


<210>  42
<211>  314
<212>  PRT
<213>  HOMO SAPIENS

<400>  42

Leu Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys 
1               5                   10                  15      


Thr His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg 
            20                  25                  30          


Leu Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu 
        35                  40                  45              


Ala Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly 
    50                  55                  60                  


Asp Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val 
65                  70                  75                  80  


Pro Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp 
                85                  90                  95      


Glu Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val 
            100                 105                 110         


Thr Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser 
        115                 120                 125             


Ser Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu 
    130                 135                 140                 


Leu Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp 
145                 150                 155                 160 


Gly Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys 
                165                 170                 175     


Asn Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu 
            180                 185                 190         


Glu Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly 
        195                 200                 205             


Tyr Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val 
    210                 215                 220                 


Ala Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser 
225                 230                 235                 240 


Phe Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser 
                245                 250                 255     


Asp Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys 
            260                 265                 270         


Gly Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly 
        275                 280                 285             


Asn Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly 
    290                 295                 300                 


Ile Ala Asn Leu Ala Ser Phe Pro Lys Met 
305                 310                 


<210>  43
<211>  279
<212>  PRT
<213>  HOMO SAPIENS

<400>  43

Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp 
1               5                   10                  15      


Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu 
            20                  25                  30          


Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr 
        35                  40                  45              


Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln 
    50                  55                  60                  


Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln 
65                  70                  75                  80  


Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala 
                85                  90                  95      


Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val 
            100                 105                 110         


Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu 
        115                 120                 125             


Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala 
    130                 135                 140                 


Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His 
145                 150                 155                 160 


Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala 
                165                 170                 175     


Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu 
            180                 185                 190         


Met Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile 
        195                 200                 205             


Val Asp Pro Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln 
    210                 215                 220                 


Ala Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp 
225                 230                 235                 240 


Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu 
                245                 250                 255     


Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala 
            260                 265                 270         


His Ile Ile Pro Phe Leu Gly 
        275                 


<210>  44
<211>  482
<212>  PRT
<213>  HOMO SAPIENS

<400>  44

Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu 
1               5                   10                  15      


Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala 
            20                  25                  30          


Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser 
        35                  40                  45              


Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His 
    50                  55                  60                  


Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser 
65                  70                  75                  80  


Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val 
                85                  90                  95      


Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr 
            100                 105                 110         


Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val 
        115                 120                 125             


Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln 
    130                 135                 140                 


Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro 
145                 150                 155                 160 


His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys 
                165                 170                 175     


Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro 
            180                 185                 190         


Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn 
        195                 200                 205             


Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly 
    210                 215                 220                 


Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala 
225                 230                 235                 240 


Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile 
                245                 250                 255     


Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu 
            260                 265                 270         


Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val 
        275                 280                 285             


Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp 
    290                 295                 300                 


Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr 
305                 310                 315                 320 


Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro 
                325                 330                 335     


Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val Thr Met 
            340                 345                 350         


Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu Val His 
        355                 360                 365             


Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val 
    370                 375                 380                 


Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro 
385                 390                 395                 400 


Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp 
                405                 410                 415     


Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala 
            420                 425                 430         


Thr Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu 
        435                 440                 445             


Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp 
    450                 455                 460                 


Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn 
465                 470                 475                 480 


Glu Leu 
        


<210>  45
<211>  560
<212>  PRT
<213>  HOMO SAPIENS

<400>  45

Lys Thr Ala Asn Ala Phe Lys Pro Asn Ile Leu Leu Ile Met Ala Asp 
1               5                   10                  15      


Asp Leu Gly Thr Gly Asp Leu Gly Cys Tyr Gly Asn Asn Thr Leu Arg 
            20                  25                  30          


Thr Pro Asn Ile Asp Gln Leu Ala Glu Glu Gly Val Arg Leu Thr Gln 
        35                  40                  45              


His Leu Ala Ala Ala Pro Leu Cys Thr Pro Ser Arg Ala Ala Phe Leu 
    50                  55                  60                  


Thr Gly Arg His Ser Phe Arg Ser Gly Met Asp Ala Ser Asn Gly Tyr 
65                  70                  75                  80  


Arg Ala Leu Gln Trp Asn Ala Gly Ser Gly Gly Leu Pro Glu Asn Glu 
                85                  90                  95      


Thr Thr Phe Ala Arg Ile Leu Gln Gln His Gly Tyr Ala Thr Gly Leu 
            100                 105                 110         


Ile Gly Lys Trp His Gln Gly Val Asn Cys Ala Ser Arg Gly Asp His 
        115                 120                 125             


Cys His His Pro Leu Asn His Gly Phe Asp Tyr Phe Tyr Gly Met Pro 
    130                 135                 140                 


Phe Thr Leu Thr Asn Asp Cys Asp Pro Gly Arg Pro Pro Glu Val Asp 
145                 150                 155                 160 


Ala Ala Leu Arg Ala Gln Leu Trp Gly Tyr Thr Gln Phe Leu Ala Leu 
                165                 170                 175     


Gly Ile Leu Thr Leu Ala Ala Gly Gln Thr Cys Gly Phe Phe Ser Val 
            180                 185                 190         


Ser Ala Arg Ala Val Thr Gly Met Ala Gly Val Gly Cys Leu Phe Phe 
        195                 200                 205             


Ile Ser Trp Tyr Ser Ser Phe Gly Phe Val Arg Arg Trp Asn Cys Ile 
    210                 215                 220                 


Leu Met Arg Asn His Asp Val Thr Glu Gln Pro Met Val Leu Glu Lys 
225                 230                 235                 240 


Thr Ala Ser Leu Met Leu Lys Glu Ala Val Ser Tyr Ile Glu Arg His 
                245                 250                 255     


Lys His Gly Pro Phe Leu Leu Phe Leu Ser Leu Leu His Val His Ile 
            260                 265                 270         


Pro Leu Val Thr Thr Ser Ala Phe Leu Gly Lys Ser Gln His Gly Leu 
        275                 280                 285             


Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Leu Ile Gly Lys Val Leu 
    290                 295                 300                 


Asn Ala Ile Glu Asp Asn Gly Leu Lys Asn Ser Thr Phe Thr Tyr Phe 
305                 310                 315                 320 


Thr Ser Asp His Gly Gly His Leu Glu Ala Arg Asp Gly His Ser Gln 
                325                 330                 335     


Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly Gly 
            340                 345                 350         


Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Phe His Trp Pro Gly Val 
        355                 360                 365             


Leu Pro Ala Gly Arg Val Ile Gly Glu Pro Thr Ser Leu Met Asp Val 
    370                 375                 380                 


Phe Pro Thr Val Val Gln Leu Val Gly Gly Glu Val Pro Gln Asp Arg 
385                 390                 395                 400 


Val Ile Asp Gly His Ser Leu Val Pro Leu Leu Gln Gly Ala Glu Ala 
                405                 410                 415     


Arg Ser Ala His Glu Phe Leu Phe His Tyr Cys Gly Gln His Leu His 
            420                 425                 430         


Ala Ala Arg Trp His Gln Lys Asp Ser Gly Ser Val Trp Lys Val His 
        435                 440                 445             


Tyr Thr Thr Pro Gln Phe His Pro Glu Gly Ala Gly Ala Cys Tyr Gly 
    450                 455                 460                 


Arg Gly Val Cys Pro Cys Ser Gly Glu Gly Val Thr His His Arg Pro 
465                 470                 475                 480 


Pro Leu Leu Phe Asp Leu Ser Arg Asp Pro Ser Glu Ala Arg Pro Leu 
                485                 490                 495     


Thr Pro Asp Ser Glu Pro Leu Tyr His Ala Val Ile Ala Arg Val Gly 
            500                 505                 510         


Ala Ala Val Ser Glu His Arg Gln Thr Leu Ser Pro Val Pro Gln Gln 
        515                 520                 525             


Phe Ser Met Ser Asn Ile Leu Trp Lys Pro Trp Leu Gln Pro Cys Cys 
    530                 535                 540                 


Gly His Phe Pro Phe Cys Ser Cys His Glu Asp Gly Asp Gly Thr Pro 
545                 550                 555                 560 


<210>  46
<211>  439
<212>  PRT
<213>  HOMO SAPIENS

<400>  46

Asp Thr Pro Ala Asn Cys Thr Tyr Leu Asp Leu Leu Gly Thr Trp Val 
1               5                   10                  15      


Phe Gln Val Gly Ser Ser Gly Ser Gln Arg Asp Val Asn Cys Ser Val 
            20                  25                  30          


Met Gly Pro Gln Glu Lys Lys Val Val Val Tyr Leu Gln Lys Leu Asp 
        35                  40                  45              


Thr Ala Tyr Asp Asp Leu Gly Asn Ser Gly His Phe Thr Ile Ile Tyr 
    50                  55                  60                  


Asn Gln Gly Phe Glu Ile Val Leu Asn Asp Tyr Lys Trp Phe Ala Phe 
65                  70                  75                  80  


Phe Lys Tyr Lys Glu Glu Gly Ser Lys Val Thr Thr Tyr Cys Asn Glu 
                85                  90                  95      


Thr Met Thr Gly Trp Val His Asp Val Leu Gly Arg Asn Trp Ala Cys 
            100                 105                 110         


Phe Thr Gly Lys Lys Val Gly Thr Ala Ser Glu Asn Val Tyr Val Asn 
        115                 120                 125             


Ile Ala His Leu Lys Asn Ser Gln Glu Lys Tyr Ser Asn Arg Leu Tyr 
    130                 135                 140                 


Lys Tyr Asp His Asn Phe Val Lys Ala Ile Asn Ala Ile Gln Lys Ser 
145                 150                 155                 160 


Trp Thr Ala Thr Thr Tyr Met Glu Tyr Glu Thr Leu Thr Leu Gly Asp 
                165                 170                 175     


Met Ile Arg Arg Ser Gly Gly His Ser Arg Lys Ile Pro Arg Pro Lys 
            180                 185                 190         


Pro Ala Pro Leu Thr Ala Glu Ile Gln Gln Lys Ile Leu His Leu Pro 
        195                 200                 205             


Thr Ser Trp Asp Trp Arg Asn Val His Gly Ile Asn Phe Val Ser Pro 
    210                 215                 220                 


Val Arg Asn Gln Ala Ser Cys Gly Ser Cys Tyr Ser Phe Ala Ser Met 
225                 230                 235                 240 


Gly Met Leu Glu Ala Arg Ile Arg Ile Leu Thr Asn Asn Ser Gln Thr 
                245                 250                 255     


Pro Ile Leu Ser Pro Gln Glu Val Val Ser Cys Ser Gln Tyr Ala Gln 
            260                 265                 270         


Gly Cys Glu Gly Gly Phe Pro Tyr Leu Ile Ala Gly Lys Tyr Ala Gln 
        275                 280                 285             


Asp Phe Gly Leu Val Glu Glu Ala Cys Phe Pro Tyr Thr Gly Thr Asp 
    290                 295                 300                 


Ser Pro Cys Lys Met Lys Glu Asp Cys Phe Arg Tyr Tyr Ser Ser Glu 
305                 310                 315                 320 


Tyr His Tyr Val Gly Gly Phe Tyr Gly Gly Cys Asn Glu Ala Leu Met 
                325                 330                 335     


Lys Leu Glu Leu Val His His Gly Pro Met Ala Val Ala Phe Glu Val 
            340                 345                 350         


Tyr Asp Asp Phe Leu His Tyr Lys Lys Gly Ile Tyr His His Thr Gly 
        355                 360                 365             


Leu Arg Asp Pro Phe Asn Pro Phe Glu Leu Thr Asn His Ala Val Leu 
    370                 375                 380                 


Leu Val Gly Tyr Gly Thr Asp Ser Ala Ser Gly Met Asp Tyr Trp Ile 
385                 390                 395                 400 


Val Lys Asn Ser Trp Gly Thr Gly Trp Gly Glu Asn Gly Tyr Phe Arg 
                405                 410                 415     


Ile Arg Arg Gly Thr Asp Glu Cys Ala Ile Glu Ser Ile Ala Val Ala 
            420                 425                 430         


Ala Thr Pro Ile Pro Lys Leu 
        435                 


<210>  47
<211>  720
<212>  PRT
<213>  HOMO SAPIENS

<400>  47

Asp Glu Ala Arg Glu Ala Ala Ala Val Arg Ala Leu Val Ala Arg Leu 
1               5                   10                  15      


Leu Gly Pro Gly Pro Ala Ala Asp Phe Ser Val Ser Val Glu Arg Ala 
            20                  25                  30          


Leu Ala Ala Lys Pro Gly Leu Asp Thr Tyr Ser Leu Gly Gly Gly Gly 
        35                  40                  45              


Ala Ala Arg Val Arg Val Arg Gly Ser Thr Gly Val Ala Ala Ala Ala 
    50                  55                  60                  


Gly Leu His Arg Tyr Leu Arg Asp Phe Cys Gly Cys His Val Ala Trp 
65                  70                  75                  80  


Ser Gly Ser Gln Leu Arg Leu Pro Arg Pro Leu Pro Ala Val Pro Gly 
                85                  90                  95      


Glu Leu Thr Glu Ala Thr Pro Asn Arg Tyr Arg Tyr Tyr Gln Asn Val 
            100                 105                 110         


Cys Thr Gln Ser Tyr Ser Phe Val Trp Trp Asp Trp Ala Arg Trp Glu 
        115                 120                 125             


Arg Glu Ile Asp Trp Met Ala Leu Asn Gly Ile Asn Leu Ala Leu Ala 
    130                 135                 140                 


Trp Ser Gly Gln Glu Ala Ile Trp Gln Arg Val Tyr Leu Ala Leu Gly 
145                 150                 155                 160 


Leu Thr Gln Ala Glu Ile Asn Glu Phe Phe Thr Gly Pro Ala Phe Leu 
                165                 170                 175     


Ala Trp Gly Arg Met Gly Asn Leu His Thr Trp Asp Gly Pro Leu Pro 
            180                 185                 190         


Pro Ser Trp His Ile Lys Gln Leu Tyr Leu Gln His Arg Val Leu Asp 
        195                 200                 205             


Gln Met Arg Ser Phe Gly Met Thr Pro Val Leu Pro Ala Phe Ala Gly 
    210                 215                 220                 


His Val Pro Glu Ala Val Thr Arg Val Phe Pro Gln Val Asn Val Thr 
225                 230                 235                 240 


Lys Met Gly Ser Trp Gly His Phe Asn Cys Ser Tyr Ser Cys Ser Phe 
                245                 250                 255     


Leu Leu Ala Pro Glu Asp Pro Ile Phe Pro Ile Ile Gly Ser Leu Phe 
            260                 265                 270         


Leu Arg Glu Leu Ile Lys Glu Phe Gly Thr Asp His Ile Tyr Gly Ala 
        275                 280                 285             


Asp Thr Phe Asn Glu Met Gln Pro Pro Ser Ser Glu Pro Ser Tyr Leu 
    290                 295                 300                 


Ala Ala Ala Thr Thr Ala Val Tyr Glu Ala Met Thr Ala Val Asp Thr 
305                 310                 315                 320 


Glu Ala Val Trp Leu Leu Gln Gly Trp Leu Phe Gln His Gln Pro Gln 
                325                 330                 335     


Phe Trp Gly Pro Ala Gln Ile Arg Ala Val Leu Gly Ala Val Pro Arg 
            340                 345                 350         


Gly Arg Leu Leu Val Leu Asp Leu Phe Ala Glu Ser Gln Pro Val Tyr 
        355                 360                 365             


Thr Arg Thr Ala Ser Phe Gln Gly Gln Pro Phe Ile Trp Cys Met Leu 
    370                 375                 380                 


His Asn Phe Gly Gly Asn His Gly Leu Phe Gly Ala Leu Glu Ala Val 
385                 390                 395                 400 


Asn Gly Gly Pro Glu Ala Ala Arg Leu Phe Pro Asn Ser Thr Met Val 
                405                 410                 415     


Gly Thr Gly Met Ala Pro Glu Gly Ile Ser Gln Asn Glu Val Val Tyr 
            420                 425                 430         


Ser Leu Met Ala Glu Leu Gly Trp Arg Lys Asp Pro Val Pro Asp Leu 
        435                 440                 445             


Ala Ala Trp Val Thr Ser Phe Ala Ala Arg Arg Tyr Gly Val Ser His 
    450                 455                 460                 


Pro Asp Ala Gly Ala Ala Trp Arg Leu Leu Leu Arg Ser Val Tyr Asn 
465                 470                 475                 480 


Cys Ser Gly Glu Ala Cys Arg Gly His Asn Arg Ser Pro Leu Val Arg 
                485                 490                 495     


Arg Pro Ser Leu Gln Met Asn Thr Ser Ile Trp Tyr Asn Arg Ser Asp 
            500                 505                 510         


Val Phe Glu Ala Trp Arg Leu Leu Leu Thr Ser Ala Pro Ser Leu Ala 
        515                 520                 525             


Thr Ser Pro Ala Phe Arg Tyr Asp Leu Leu Asp Leu Thr Arg Gln Ala 
    530                 535                 540                 


Val Gln Glu Leu Val Ser Leu Tyr Tyr Glu Glu Ala Arg Ser Ala Tyr 
545                 550                 555                 560 


Leu Ser Lys Glu Leu Ala Ser Leu Leu Arg Ala Gly Gly Val Leu Ala 
                565                 570                 575     


Tyr Glu Leu Leu Pro Ala Leu Asp Glu Val Leu Ala Ser Asp Ser Arg 
            580                 585                 590         


Phe Leu Leu Gly Ser Trp Leu Glu Gln Ala Arg Ala Ala Ala Val Ser 
        595                 600                 605             


Glu Ala Glu Ala Asp Phe Tyr Glu Gln Asn Ser Arg Tyr Gln Leu Thr 
    610                 615                 620                 


Leu Trp Gly Pro Glu Gly Asn Ile Leu Asp Tyr Ala Asn Lys Gln Leu 
625                 630                 635                 640 


Ala Gly Leu Val Ala Asn Tyr Tyr Thr Pro Arg Trp Arg Leu Phe Leu 
                645                 650                 655     


Glu Ala Leu Val Asp Ser Val Ala Gln Gly Ile Pro Phe Gln Gln His 
            660                 665                 670         


Gln Phe Asp Lys Asn Val Phe Gln Leu Glu Gln Ala Phe Val Leu Ser 
        675                 680                 685             


Lys Gln Arg Tyr Pro Ser Gln Pro Arg Gly Asp Thr Val Asp Leu Ala 
    690                 695                 700                 


Lys Lys Ile Phe Leu Lys Tyr Tyr Pro Arg Trp Val Ala Gly Ser Trp 
705                 710                 715                 720 


<210>  48
<211>  643
<212>  PRT
<213>  HOMO SAPIENS

<400>  48

Tyr Val Leu Asp Asp Ser Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile 
1               5                   10                  15      


Gly Ala Val Ser Gly Gly Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr 
            20                  25                  30          


Pro Glu Pro Tyr Arg Ser Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn 
        35                  40                  45              


Phe Gly Ala Ser Leu His Ile Leu Lys Val Glu Ile Gly Gly Asp Gly 
    50                  55                  60                  


Gln Thr Thr Asp Gly Thr Glu Pro Ser His Met His Tyr Ala Leu Asp 
65                  70                  75                  80  


Glu Asn Tyr Phe Arg Gly Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys 
                85                  90                  95      


Lys Arg Asn Pro Asn Ile Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro 
            100                 105                 110         


Gly Trp Leu Gly Lys Gly Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu 
        115                 120                 125             


Thr Ala Tyr Tyr Val Val Thr Trp Ile Val Gly Ala Lys Arg Tyr His 
    130                 135                 140                 


Asp Leu Asp Ile Asp Tyr Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn 
145                 150                 155                 160 


Ala Asn Tyr Ile Lys Ile Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu 
                165                 170                 175     


Gln Arg Val Lys Ile Ile Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser 
            180                 185                 190         


Ala Ser Met Leu Leu Asp Ala Glu Leu Phe Lys Val Val Asp Val Ile 
        195                 200                 205             


Gly Ala His Tyr Pro Gly Thr His Ser Ala Lys Asp Ala Lys Leu Thr 
    210                 215                 220                 


Gly Lys Lys Leu Trp Ser Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp 
225                 230                 235                 240 


Met Gly Ala Gly Cys Trp Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn 
                245                 250                 255     


Gly Tyr Met Thr Ser Thr Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr 
            260                 265                 270         


Glu Gln Leu Pro Tyr Gly Arg Cys Gly Leu Met Thr Ala Gln Glu Pro 
        275                 280                 285             


Trp Ser Gly His Tyr Val Val Glu Ser Pro Val Trp Val Ser Ala His 
    290                 295                 300                 


Thr Thr Gln Phe Thr Gln Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly 
305                 310                 315                 320 


His Leu Glu Lys Gly Gly Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly 
                325                 330                 335     


Asn Leu Thr Ile Ile Ile Glu Thr Met Ser His Lys His Ser Lys Cys 
            340                 345                 350         


Ile Arg Pro Phe Leu Pro Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr 
        355                 360                 365             


Phe Val Leu Lys Gly Ser Phe Ser Glu Ile Pro Glu Leu Gln Val Trp 
    370                 375                 380                 


Tyr Thr Lys Leu Gly Lys Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu 
385                 390                 395                 400 


Asp Ser Leu Trp Leu Leu Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu 
                405                 410                 415     


His Glu Asp Glu Leu Phe Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys 
            420                 425                 430         


Gly Ser Tyr Pro Leu Pro Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr 
        435                 440                 445             


Lys Asp Asp Phe Asn Val Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn 
    450                 455                 460                 


Phe Ala Asp Gln Thr Gly Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp 
465                 470                 475                 480 


Pro Gly Glu His His Phe Thr Leu Arg Gln Val Leu Asn Gln Arg Pro 
                485                 490                 495     


Ile Thr Trp Ala Ala Asp Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp 
            500                 505                 510         


Tyr Asn Trp Thr Asn Leu Thr Ile Lys Cys Asp Val Tyr Ile Glu Thr 
        515                 520                 525             


Pro Asp Thr Gly Gly Val Phe Ile Ala Gly Arg Val Asn Lys Gly Gly 
    530                 535                 540                 


Ile Leu Ile Arg Ser Ala Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn 
545                 550                 555                 560 


Gly Ser Tyr Arg Val Thr Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala 
                565                 570                 575     


Leu Gly Arg Val Glu Val Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu 
            580                 585                 590         


Thr Ile Lys Gly His Phe Ala Ser Gly Met Leu Asn Asp Lys Ser Leu 
        595                 600                 605             


Trp Thr Asp Ile Pro Val Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile 
    610                 615                 620                 


Gly Thr His Ser Phe Glu Phe Ala Gln Phe Asp Asn Phe Leu Val Glu 
625                 630                 635                 640 


Ala Thr Arg 
            


<210>  49
<211>  132
<212>  PRT
<213>  HOMO SAPIENS

<400>  49

Glu Pro Val Gln Phe Lys Asp Cys Gly Ser Val Asp Gly Val Ile Lys 
1               5                   10                  15      


Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln Leu Ser Lys 
            20                  25                  30          


Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn Ile Gln Ser 
        35                  40                  45              


Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly Val Pro Val 
    50                  55                  60                  


Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly Ile Asn Cys 
65                  70                  75                  80  


Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys Leu Pro Val 
                85                  90                  95      


Lys Ser Glu Tyr Pro Ser Ile Lys Leu Val Val Glu Trp Gln Leu Gln 
            100                 105                 110         


Asp Asp Lys Asn Gln Ser Leu Phe Cys Trp Glu Ile Pro Val Gln Ile 
        115                 120                 125             


Val Ser His Leu 
    130         


<210>  50
<211>  347
<212>  PRT
<213>  HOMO SAPIENS

<400>  50

Thr Asp Cys Pro Cys Pro Glu Pro Glu Leu Cys Arg Pro Ile Arg His 
1               5                   10                  15      


His Pro Asp Phe Glu Val Phe Val Phe Asp Val Gly Gln Lys Thr Trp 
            20                  25                  30          


Lys Ser Tyr Asp Trp Ser Gln Ile Thr Thr Val Ala Thr Phe Gly Lys 
        35                  40                  45              


Tyr Asp Ser Glu Leu Met Cys Tyr Ala His Ser Lys Gly Ala Arg Val 
    50                  55                  60                  


Val Leu Lys Gly Asp Val Ser Leu Lys Asp Ile Ile Asp Pro Ala Phe 
65                  70                  75                  80  


Arg Ala Ser Trp Ile Ala Gln Lys Leu Asn Leu Ala Lys Thr Gln Tyr 
                85                  90                  95      


Met Asp Gly Ile Asn Ile Asp Ile Glu Gln Glu Val Asn Cys Leu Ser 
            100                 105                 110         


Pro Glu Tyr Asp Ala Leu Thr Ala Leu Val Lys Glu Thr Thr Asp Ser 
        115                 120                 125             


Phe His Arg Glu Ile Glu Gly Ser Gln Val Thr Phe Asp Val Ala Trp 
    130                 135                 140                 


Ser Pro Lys Asn Ile Asp Arg Arg Cys Tyr Asn Tyr Thr Gly Ile Ala 
145                 150                 155                 160 


Asp Ala Cys Asp Phe Leu Phe Val Met Ser Tyr Asp Glu Gln Ser Gln 
                165                 170                 175     


Ile Trp Ser Glu Cys Ile Ala Ala Ala Asn Ala Pro Tyr Asn Gln Thr 
            180                 185                 190         


Leu Thr Gly Tyr Asn Asp Tyr Ile Lys Met Ser Ile Asn Pro Lys Lys 
        195                 200                 205             


Leu Val Met Gly Val Pro Trp Tyr Gly Tyr Asp Tyr Thr Cys Leu Asn 
    210                 215                 220                 


Leu Ser Glu Asp His Val Cys Thr Ile Ala Lys Val Pro Phe Arg Gly 
225                 230                 235                 240 


Ala Pro Cys Ser Asp Ala Ala Gly Arg Gln Val Pro Tyr Lys Thr Ile 
                245                 250                 255     


Met Lys Gln Ile Asn Ser Ser Ile Ser Gly Asn Leu Trp Asp Lys Asp 
            260                 265                 270         


Gln Arg Ala Pro Tyr Tyr Asn Tyr Lys Asp Pro Ala Gly His Phe His 
        275                 280                 285             


Gln Val Trp Tyr Asp Asn Pro Gln Ser Ile Ser Leu Lys Ala Thr Tyr 
    290                 295                 300                 


Ile Gln Asn Tyr Arg Leu Arg Gly Ile Gly Met Trp Asn Ala Asn Cys 
305                 310                 315                 320 


Leu Asp Tyr Ser Gly Asp Ala Val Ala Lys Gln Gln Thr Glu Glu Met 
                325                 330                 335     


Trp Glu Val Leu Lys Pro Lys Leu Leu Gln Arg 
            340                 345         


<210>  51
<211>  331
<212>  PRT
<213>  HOMO SAPIENS

<400>  51

Ser Pro Pro Ala Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro 
1               5                   10                  15      


Glu Leu Arg Trp Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val 
            20                  25                  30          


Arg Ala Ala Met Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val 
        35                  40                  45              


His Val Leu Ile Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro 
    50                  55                  60                  


Gln Pro Phe Thr Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu 
65                  70                  75                  80  


Ser Leu Ala Asp Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val 
                85                  90                  95      


Phe Cys Thr Ser Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His 
            100                 105                 110         


Gly Arg Asn Leu Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr 
        115                 120                 125             


Val Asp Val Gln Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr 
    130                 135                 140                 


Thr Phe Ile Gly Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys 
145                 150                 155                 160 


Phe Thr Val Ser Gly Asp Glu Arg Asp Lys Gly Trp Trp Trp Glu Asn 
                165                 170                 175     


Ala Ile Ala Ala Leu Phe Arg Arg His Ile Pro Val Ser Trp Leu Ile 
            180                 185                 190         


Arg Ala Thr Leu Ser Glu Ser Glu Asn Phe Glu Ala Ala Val Gly Lys 
        195                 200                 205             


Leu Ala Lys Thr Pro Leu Ile Ala Asp Val Tyr Tyr Ile Val Gly Gly 
    210                 215                 220                 


Thr Ser Pro Arg Glu Gly Val Val Ile Thr Arg Asn Arg Asp Gly Pro 
225                 230                 235                 240 


Ala Asp Ile Trp Pro Leu Asp Pro Leu Asn Gly Ala Trp Phe Arg Val 
                245                 250                 255     


Glu Thr Asn Tyr Asp His Trp Lys Pro Ala Pro Lys Glu Asp Asp Arg 
            260                 265                 270         


Arg Thr Ser Ala Ile Lys Ala Leu Asn Ala Thr Gly Gln Ala Asn Leu 
        275                 280                 285             


Ser Leu Glu Ala Leu Phe Gln Ile Leu Ser Val Val Pro Val Tyr Asn 
    290                 295                 300                 


Asn Phe Thr Ile Tyr Thr Thr Val Met Ser Ala Gly Ser Pro Asp Lys 
305                 310                 315                 320 


Tyr Met Thr Arg Ile Arg Asn Pro Ser Arg Lys 
                325                 330     


<210>  52
<211>  414
<212>  PRT
<213>  HOMO SAPIENS

<400>  52

Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe Thr Thr Val Trp Asn 
1               5                   10                  15      


Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly Val Asp Val Asp Val 
            20                  25                  30          


Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln Thr Phe Arg Gly Pro 
        35                  40                  45              


Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly Thr Tyr Pro Tyr Tyr 
    50                  55                  60                  


Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu Pro Gln Asn Ala Ser 
65                  70                  75                  80  


Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp Ile Leu Ala Ala Ile 
                85                  90                  95      


Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile Asp Trp Glu Ala Trp 
            100                 105                 110         


Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys Asp Ile Tyr Arg Gln 
        115                 120                 125             


Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro Asp Trp Pro Ala Pro 
    130                 135                 140                 


Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln Gly Ala Ala Arg Ala 
145                 150                 155                 160 


Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala Leu Arg Pro Arg Gly 
                165                 170                 175     


Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr Asn Tyr Asp Phe Leu 
            180                 185                 190         


Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly Ile Arg Ala Gln Asn 
        195                 200                 205             


Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg Ala Leu Tyr Pro Ser 
    210                 215                 220                 


Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly Lys Ser Gln Met Tyr 
225                 230                 235                 240 


Val Gln His Arg Val Ala Glu Ala Phe Arg Val Ala Val Ala Ala Gly 
                245                 250                 255     


Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln Ile Phe Tyr Asp Thr 
            260                 265                 270         


Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu His Ser Leu Gly Glu 
        275                 280                 285             


Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu Trp Val Ser Trp Glu 
    290                 295                 300                 


Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile Lys Glu Tyr Met Asp 
305                 310                 315                 320 


Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr Ser Gly Ala Leu Leu 
                325                 330                 335     


Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg Cys Val Arg Arg Thr 
            340                 345                 350         


Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro Ala Ser Phe Ser Ile 
        355                 360                 365             


Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu Arg Gly Ala Leu Ser 
    370                 375                 380                 


Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe Lys Cys Arg Cys Tyr 
385                 390                 395                 400 


Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys Ser Met Trp 
                405                 410                 


<210>  53
<211>  445
<212>  PRT
<213>  HOMO SAPIENS

<400>  53

Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Gln Gly 
1               5                   10                  15      


Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro Ser Leu Cys Thr His 
            20                  25                  30          


Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His Gln Leu Ser Thr Thr 
        35                  40                  45              


Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe Asn Gly Leu Lys Lys 
    50                  55                  60                  


Met Asn Pro Lys Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe 
65                  70                  75                  80  


Gly Thr Gln Lys Phe Thr Asp Met Val Ala Thr Ala Asn Asn Arg Gln 
                85                  90                  95      


Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg Lys Tyr Ser Phe Asp 
            100                 105                 110         


Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser Gln Gly Ser Pro Ala 
        115                 120                 125             


Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln Asp Leu Ala Asn Ala 
    130                 135                 140                 


Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu Arg Leu Leu Leu Ser 
145                 150                 155                 160 


Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp Ala Gly Tyr Glu Val 
                165                 170                 175     


Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn Leu Met Ala Tyr Asp 
            180                 185                 190         


Phe His Gly Ser Trp Glu Lys Val Thr Gly His Asn Ser Pro Leu Tyr 
        195                 200                 205             


Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser Leu Asn Val Asp Ala 
    210                 215                 220                 


Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro Ala Ser Lys Leu Ile 
225                 230                 235                 240 


Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr Leu Ala Ser Ser Ser 
                245                 250                 255     


Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser Gly Thr Pro Gly Pro 
            260                 265                 270         


Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr Glu Val Cys Ser Trp 
        275                 280                 285             


Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln Lys Val Pro Tyr Ile 
    290                 295                 300                 


Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp Val Glu Ser Phe Lys 
305                 310                 315                 320 


Thr Lys Val Ser Tyr Leu Lys Gln Lys Gly Leu Gly Gly Ala Met Val 
                325                 330                 335     


Trp Ala Leu Asp Leu Asp Asp Phe Ala Gly Phe Ser Cys Asn Gln Gly 
            340                 345                 350         


Arg Tyr Pro Leu Ile Gln Thr Leu Arg Gln Glu Leu Ser Leu Pro Tyr 
        355                 360                 365             


Leu Pro Ser Gly Thr Pro Glu Leu Glu Val Pro Lys Pro Gly Gln Pro 
    370                 375                 380                 


Ser Glu Pro Glu His Gly Pro Ser Pro Gly Gln Asp Thr Phe Cys Gln 
385                 390                 395                 400 


Gly Lys Ala Asp Gly Leu Tyr Pro Asn Pro Arg Glu Arg Ser Ser Phe 
                405                 410                 415     


Tyr Ser Cys Ala Ala Gly Arg Leu Phe Gln Gln Ser Cys Pro Thr Gly 
            420                 425                 430         


Leu Val Phe Ser Asn Ser Cys Lys Cys Cys Thr Trp Asn 
        435                 440                 445 


<210>  54
<211>  374
<212>  PRT
<213>  HOMO SAPIENS

<400>  54

Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg Lys Ser Thr Tyr Pro 
1               5                   10                  15      


Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro Trp Tyr Thr Ile Asn 
            20                  25                  30          


Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu Leu Met Leu Asp Lys 
        35                  40                  45              


Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu Lys Asn Met Ile Asn 
    50                  55                  60                  


Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val Val Asp Glu Lys Leu 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu Glu Glu Met Lys 
                85                  90                  95      


Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Glu Ile Ile Ser Phe 
            100                 105                 110         


Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr Ser Ile Val Ala Glu 
        115                 120                 125             


Asp Lys Lys Gly His Leu Ile His Gly Arg Asn Met Asp Phe Gly Val 
    130                 135                 140                 


Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val Ile Thr Glu Gln 
145                 150                 155                 160 


Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg Asn Asn Lys Thr 
                165                 170                 175     


Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly Met Leu Thr Gly 
            180                 185                 190         


Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn Glu Arg Phe Ser Ile 
        195                 200                 205             


Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile Leu Gly Lys Lys Asp 
    210                 215                 220                 


Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu Glu Asn Ser Thr 
225                 230                 235                 240 


Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr Lys Ile Leu Ala 
                245                 250                 255     


Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly Glu Gly Cys Val 
            260                 265                 270         


Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr Glu Leu Asp Ala 
        275                 280                 285             


Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr Asp Arg Trp Lys 
    290                 295                 300                 


His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala Lys Met Cys Leu 
305                 310                 315                 320 


Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr Met Tyr Asp Val 
                325                 330                 335     


Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val Tyr Thr Thr Leu 
            340                 345                 350         


Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu Arg Asp Cys Pro 
        355                 360                 365             


Asp Pro Cys Ile Gly Trp 
    370                 


<210>  55
<211>  515
<212>  PRT
<213>  HOMO SAPIENS

<400>  55

Gly Val Tyr Tyr Ala Thr Ala Tyr Trp Met Pro Ala Glu Lys Thr Val 
1               5                   10                  15      


Gln Val Lys Asn Val Met Asp Lys Asn Gly Asp Ala Tyr Gly Phe Tyr 
            20                  25                  30          


Asn Asn Ser Val Lys Thr Thr Gly Trp Gly Ile Leu Glu Ile Arg Ala 
        35                  40                  45              


Gly Tyr Gly Ser Gln Thr Leu Ser Asn Glu Ile Ile Met Phe Val Ala 
    50                  55                  60                  


Gly Phe Leu Glu Gly Tyr Leu Thr Ala Pro His Met Asn Asp His Tyr 
65                  70                  75                  80  


Thr Asn Leu Tyr Pro Gln Leu Ile Thr Lys Pro Ser Ile Met Asp Lys 
                85                  90                  95      


Val Gln Asp Phe Met Glu Lys Gln Asp Lys Trp Thr Arg Lys Asn Ile 
            100                 105                 110         


Lys Glu Tyr Lys Thr Asp Ser Phe Trp Arg His Thr Gly Tyr Val Met 
        115                 120                 125             


Ala Gln Ile Asp Gly Leu Tyr Val Gly Ala Lys Lys Arg Ala Ile Leu 
    130                 135                 140                 


Glu Gly Thr Lys Pro Met Thr Leu Phe Gln Ile Gln Phe Leu Asn Ser 
145                 150                 155                 160 


Val Gly Asp Leu Leu Asp Leu Ile Pro Ser Leu Ser Pro Thr Lys Asn 
                165                 170                 175     


Gly Ser Leu Lys Val Phe Lys Arg Trp Asp Met Gly His Cys Ser Ala 
            180                 185                 190         


Leu Ile Lys Val Leu Pro Gly Phe Glu Asn Ile Leu Phe Ala His Ser 
        195                 200                 205             


Ser Trp Tyr Thr Tyr Ala Ala Met Leu Arg Ile Tyr Lys His Trp Asp 
    210                 215                 220                 


Phe Asn Val Ile Asp Lys Asp Thr Ser Ser Ser Arg Leu Ser Phe Ser 
225                 230                 235                 240 


Ser Tyr Pro Gly Phe Leu Glu Ser Leu Asp Asp Phe Tyr Ile Leu Ser 
                245                 250                 255     


Ser Gly Leu Ile Leu Leu Gln Thr Thr Asn Ser Val Phe Asn Lys Thr 
            260                 265                 270         


Leu Leu Lys Gln Val Ile Pro Glu Thr Leu Leu Ser Trp Gln Arg Val 
        275                 280                 285             


Arg Val Ala Asn Met Met Ala Asp Ser Gly Lys Arg Trp Ala Asp Ile 
    290                 295                 300                 


Phe Ser Lys Tyr Asn Ser Gly Thr Tyr Asn Asn Gln Tyr Met Val Leu 
305                 310                 315                 320 


Asp Leu Lys Lys Val Lys Leu Asn His Ser Leu Asp Lys Gly Thr Leu 
                325                 330                 335     


Tyr Ile Val Glu Gln Ile Pro Thr Tyr Val Glu Tyr Ser Glu Gln Thr 
            340                 345                 350         


Asp Val Leu Arg Lys Gly Tyr Trp Pro Ser Tyr Asn Val Pro Phe His 
        355                 360                 365             


Glu Lys Ile Tyr Asn Trp Ser Gly Tyr Pro Leu Leu Val Gln Lys Leu 
    370                 375                 380                 


Gly Leu Asp Tyr Ser Tyr Asp Leu Ala Pro Arg Ala Lys Ile Phe Arg 
385                 390                 395                 400 


Arg Asp Gln Gly Lys Val Thr Asp Thr Ala Ser Met Lys Tyr Ile Met 
                405                 410                 415     


Arg Tyr Asn Asn Tyr Lys Lys Asp Pro Tyr Ser Arg Gly Asp Pro Cys 
            420                 425                 430         


Asn Thr Ile Cys Cys Arg Glu Asp Leu Asn Ser Pro Asn Pro Ser Pro 
        435                 440                 445             


Gly Gly Cys Tyr Asp Thr Lys Val Ala Asp Ile Tyr Leu Ala Ser Gln 
    450                 455                 460                 


Tyr Thr Ser Tyr Ala Ile Ser Gly Pro Thr Val Gln Gly Gly Leu Pro 
465                 470                 475                 480 


Val Phe Arg Trp Asp Arg Phe Asn Lys Thr Leu His Gln Gly Met Pro 
                485                 490                 495     


Glu Val Tyr Asn Phe Asp Phe Ile Thr Met Lys Pro Ile Leu Lys Leu 
            500                 505                 510         


Asp Ile Lys 
        515 


<210>  56
<211>  662
<212>  PRT
<213>  HOMO SAPIENS

<400>  56

Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg 
1               5                   10                  15      


Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala 
            20                  25                  30          


Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr 
        35                  40                  45              


Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr 
    50                  55                  60                  


Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys 
65                  70                  75                  80  


Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met 
                85                  90                  95      


Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr 
            100                 105                 110         


Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu 
        115                 120                 125             


Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro 
    130                 135                 140                 


Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln 
145                 150                 155                 160 


Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu 
                165                 170                 175     


Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
            180                 185                 190         


Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp 
        195                 200                 205             


Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn 
    210                 215                 220                 


Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe 
225                 230                 235                 240 


Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu 
                245                 250                 255     


Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
            260                 265                 270         


Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe 
        275                 280                 285             


Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile 
    290                 295                 300                 


Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr 
305                 310                 315                 320 


Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu 
                325                 330                 335     


Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
            340                 345                 350         


Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met 
        355                 360                 365             


Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg 
    370                 375                 380                 


Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro 
385                 390                 395                 400 


Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro 
                405                 410                 415     


Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser 
            420                 425                 430         


Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala 
        435                 440                 445             


Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys 
    450                 455                 460                 


Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg 
465                 470                 475                 480 


Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys 
                485                 490                 495     


Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala 
            500                 505                 510         


Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val 
        515                 520                 525             


Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His 
    530                 535                 540                 


Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly 
545                 550                 555                 560 


His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu 
                565                 570                 575     


Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val 
            580                 585                 590         


Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu 
        595                 600                 605             


Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys 
    610                 615                 620                 


Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly 
625                 630                 635                 640 


Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln 
                645                 650                 655     


Ala Ser Gln Glu Leu Gln 
            660         


<210>  57
<211>  379
<212>  PRT
<213>  HOMO SAPIENS

<400>  57

Ala Gly Arg His Pro Pro Val Val Leu Val Pro Gly Asp Leu Gly Asn 
1               5                   10                  15      


Gln Leu Glu Ala Lys Leu Asp Lys Pro Thr Val Val His Tyr Leu Cys 
            20                  25                  30          


Ser Lys Lys Thr Glu Ser Tyr Phe Thr Ile Trp Leu Asn Leu Glu Leu 
        35                  40                  45              


Leu Leu Pro Val Ile Ile Asp Cys Trp Ile Asp Asn Ile Arg Leu Val 
    50                  55                  60                  


Tyr Asn Lys Thr Ser Arg Ala Thr Gln Phe Pro Asp Gly Val Asp Val 
65                  70                  75                  80  


Arg Val Pro Gly Phe Gly Lys Thr Phe Ser Leu Glu Phe Leu Asp Pro 
                85                  90                  95      


Ser Lys Ser Ser Val Gly Ser Tyr Phe His Thr Met Val Glu Ser Leu 
            100                 105                 110         


Val Gly Trp Gly Tyr Thr Arg Gly Glu Asp Val Arg Gly Ala Pro Tyr 
        115                 120                 125             


Asp Trp Arg Arg Ala Pro Asn Glu Asn Gly Pro Tyr Phe Leu Ala Leu 
    130                 135                 140                 


Arg Glu Met Ile Glu Glu Met Tyr Gln Leu Tyr Gly Gly Pro Val Val 
145                 150                 155                 160 


Leu Val Ala His Ser Met Gly Asn Met Tyr Thr Leu Tyr Phe Leu Gln 
                165                 170                 175     


Arg Gln Pro Gln Ala Trp Lys Asp Lys Tyr Ile Arg Ala Phe Val Ser 
            180                 185                 190         


Leu Gly Ala Pro Trp Gly Gly Val Ala Lys Thr Leu Arg Val Leu Ala 
        195                 200                 205             


Ser Gly Asp Asn Asn Arg Ile Pro Val Ile Gly Pro Leu Lys Ile Arg 
    210                 215                 220                 


Glu Gln Gln Arg Ser Ala Val Ser Thr Ser Trp Leu Leu Pro Tyr Asn 
225                 230                 235                 240 


Tyr Thr Trp Ser Pro Glu Lys Val Phe Val Gln Thr Pro Thr Ile Asn 
                245                 250                 255     


Tyr Thr Leu Arg Asp Tyr Arg Lys Phe Phe Gln Asp Ile Gly Phe Glu 
            260                 265                 270         


Asp Gly Trp Leu Met Arg Gln Asp Thr Glu Gly Leu Val Glu Ala Thr 
        275                 280                 285             


Met Pro Pro Gly Val Gln Leu His Cys Leu Tyr Gly Thr Gly Val Pro 
    290                 295                 300                 


Thr Pro Asp Ser Phe Tyr Tyr Glu Ser Phe Pro Asp Arg Asp Pro Lys 
305                 310                 315                 320 


Ile Cys Phe Gly Asp Gly Asp Gly Thr Val Asn Leu Lys Ser Ala Leu 
                325                 330                 335     


Gln Cys Gln Ala Trp Gln Ser Arg Gln Glu His Gln Val Leu Leu Gln 
            340                 345                 350         


Glu Leu Pro Gly Ser Glu His Ile Glu Met Leu Ala Asn Ala Thr Thr 
        355                 360                 365             


Leu Ala Tyr Leu Lys Arg Val Leu Leu Gly Pro 
    370                 375                 


<210>  58
<211>  548
<212>  PRT
<213>  HOMO SAPIENS

<400>  58

Ile Pro Ala Pro Gly Gly Arg Trp Ala Arg Asp Gly Gln Val Pro Pro 
1               5                   10                  15      


Ala Ser Arg Ser Arg Ser Val Leu Leu Asp Val Ser Ala Gly Gln Leu 
            20                  25                  30          


Leu Met Val Asp Gly Arg His Pro Asp Ala Val Ala Trp Ala Asn Leu 
        35                  40                  45              


Thr Asn Ala Ile Arg Glu Thr Gly Trp Ala Phe Leu Glu Leu Gly Thr 
    50                  55                  60                  


Ser Gly Gln Tyr Asn Asp Ser Leu Gln Ala Tyr Ala Ala Gly Val Val 
65                  70                  75                  80  


Glu Ala Ala Val Ser Glu Glu Leu Ile Tyr Met His Trp Met Asn Thr 
                85                  90                  95      


Val Val Asn Tyr Cys Gly Pro Phe Glu Tyr Glu Val Gly Tyr Cys Glu 
            100                 105                 110         


Arg Leu Lys Ser Phe Leu Glu Ala Asn Leu Glu Trp Met Gln Glu Glu 
        115                 120                 125             


Met Glu Ser Asn Pro Asp Ser Pro Tyr Trp His Gln Val Arg Leu Thr 
    130                 135                 140                 


Leu Leu Gln Leu Lys Gly Leu Glu Asp Ser Tyr Glu Gly Arg Val Ser 
145                 150                 155                 160 


Phe Pro Ala Gly Lys Phe Thr Ile Lys Pro Leu Gly Phe Leu Leu Leu 
                165                 170                 175     


Gln Leu Ser Gly Asp Leu Glu Asp Leu Glu Leu Ala Leu Asn Lys Thr 
            180                 185                 190         


Lys Ile Lys Pro Ser Leu Gly Ser Gly Ser Cys Ser Ala Leu Ile Lys 
        195                 200                 205             


Leu Leu Pro Gly Gln Ser Asp Leu Leu Val Ala His Asn Thr Trp Asn 
    210                 215                 220                 


Asn Tyr Gln His Met Leu Arg Val Ile Lys Lys Tyr Trp Leu Gln Phe 
225                 230                 235                 240 


Arg Glu Gly Pro Trp Gly Asp Tyr Pro Leu Val Pro Gly Asn Lys Leu 
                245                 250                 255     


Val Phe Ser Ser Tyr Pro Gly Thr Ile Phe Ser Cys Asp Asp Phe Tyr 
            260                 265                 270         


Ile Leu Gly Ser Gly Leu Val Thr Leu Glu Thr Thr Ile Gly Asn Lys 
        275                 280                 285             


Asn Pro Ala Leu Trp Lys Tyr Val Arg Pro Arg Gly Cys Val Leu Glu 
    290                 295                 300                 


Trp Val Arg Asn Ile Val Ala Asn Arg Leu Ala Ser Asp Gly Ala Thr 
305                 310                 315                 320 


Trp Ala Asp Ile Phe Lys Arg Phe Asn Ser Gly Thr Tyr Asn Asn Gln 
                325                 330                 335     


Trp Met Ile Val Asp Tyr Lys Ala Phe Ile Pro Gly Gly Pro Ser Pro 
            340                 345                 350         


Gly Ser Arg Val Leu Thr Ile Leu Glu Gln Ile Pro Gly Met Val Val 
        355                 360                 365             


Val Ala Asp Lys Thr Ser Glu Leu Tyr Gln Lys Thr Tyr Trp Ala Ser 
    370                 375                 380                 


Tyr Asn Ile Pro Ser Phe Glu Thr Val Phe Asn Ala Ser Gly Leu Gln 
385                 390                 395                 400 


Ala Leu Val Ala Gln Tyr Gly Asp Trp Phe Ser Tyr Asp Gly Ser Pro 
                405                 410                 415     


Arg Ala Gln Ile Phe Arg Arg Asn Gln Ser Leu Val Gln Asp Met Asp 
            420                 425                 430         


Ser Met Val Arg Leu Met Arg Tyr Asn Asp Phe Leu His Asp Pro Leu 
        435                 440                 445             


Ser Leu Cys Lys Ala Cys Asn Pro Gln Pro Asn Gly Glu Asn Ala Ile 
    450                 455                 460                 


Ser Ala Arg Ser Asp Leu Asn Pro Ala Asn Gly Ser Tyr Pro Phe Gln 
465                 470                 475                 480 


Ala Leu Arg Gln Arg Ser His Gly Gly Ile Asp Val Lys Val Thr Ser 
                485                 490                 495     


Met Ser Leu Ala Arg Ile Leu Ser Leu Leu Ala Ala Ser Gly Pro Thr 
            500                 505                 510         


Trp Asp Gln Val Pro Pro Phe Gln Trp Ser Thr Ser Pro Phe Ser Gly 
        515                 520                 525             


Leu Leu His Met Gly Gln Pro Asp Leu Trp Lys Phe Ala Pro Val Lys 
    530                 535                 540                 


Val Ser Trp Asp 
545             


<210>  59
<211>  334
<212>  PRT
<213>  HOMO SAPIENS

<400>  59

Ala Thr Ile Ser Cys Arg Asn Glu Glu Gly Lys Ala Val Asp Trp Phe 
1               5                   10                  15      


Thr Phe Tyr Lys Leu Pro Lys Arg Gln Asn Lys Glu Ser Gly Glu Thr 
            20                  25                  30          


Gly Leu Glu Tyr Leu Tyr Leu Asp Ser Thr Thr Arg Ser Trp Arg Lys 
        35                  40                  45              


Ser Glu Gln Leu Met Asn Asp Thr Lys Ser Val Leu Gly Arg Thr Leu 
    50                  55                  60                  


Gln Gln Leu Tyr Glu Ala Tyr Ala Ser Lys Ser Asn Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Ile Tyr Asn Asp Gly Val Pro Lys Pro Val Asn Tyr Ser Arg Lys 
                85                  90                  95      


Tyr Gly His Thr Lys Gly Leu Leu Leu Trp Asn Arg Val Gln Gly Phe 
            100                 105                 110         


Trp Leu Ile His Ser Ile Pro Gln Phe Pro Pro Ile Pro Glu Glu Gly 
        115                 120                 125             


Tyr Asp Tyr Pro Pro Thr Gly Arg Arg Asn Gly Gln Ser Gly Ile Cys 
    130                 135                 140                 


Ile Thr Phe Lys Tyr Asn Gln Tyr Glu Ala Ile Asp Ser Gln Leu Leu 
145                 150                 155                 160 


Val Cys Asn Pro Asn Val Tyr Ser Cys Ser Ile Pro Ala Thr Phe His 
                165                 170                 175     


Gln Glu Leu Ile His Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser 
            180                 185                 190         


Glu Ile Pro Gly Arg Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln 
        195                 200                 205             


Lys Phe Leu His Phe Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe 
    210                 215                 220                 


Ala Ala Trp Met Ala Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr 
225                 230                 235                 240 


Trp Gln Arg Lys Arg Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr 
                245                 250                 255     


His Val Tyr Asn Ile Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe 
            260                 265                 270         


Ser Ser Tyr Gln Asp His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr 
        275                 280                 285             


Lys Asn Arg Trp Thr Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln 
    290                 295                 300                 


Ala Phe Arg Ser Gly Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr 
305                 310                 315                 320 


Gln Ala Phe Gln Gly Leu Val Leu Tyr Tyr Glu Ser Cys Lys 
                325                 330                 


<210>  60
<211>  294
<212>  PRT
<213>  HOMO SAPIENS

<400>  60

Arg Pro His Gly Asp Thr Ala Lys Lys Pro Ile Ile Gly Ile Leu Met 
1               5                   10                  15      


Gln Lys Cys Arg Asn Lys Val Met Lys Asn Tyr Gly Arg Tyr Tyr Ile 
            20                  25                  30          


Ala Ala Ser Tyr Val Lys Tyr Leu Glu Ser Ala Gly Ala Arg Val Val 
        35                  40                  45              


Pro Val Arg Leu Asp Leu Thr Glu Lys Asp Tyr Glu Ile Leu Phe Lys 
    50                  55                  60                  


Ser Ile Asn Gly Ile Leu Phe Pro Gly Gly Ser Val Asp Leu Arg Arg 
65                  70                  75                  80  


Ser Asp Tyr Ala Lys Val Ala Lys Ile Phe Tyr Asn Leu Ser Ile Gln 
                85                  90                  95      


Ser Phe Asp Asp Gly Asp Tyr Phe Pro Val Trp Gly Thr Cys Leu Gly 
            100                 105                 110         


Phe Glu Glu Leu Ser Leu Leu Ile Ser Gly Glu Cys Leu Leu Thr Ala 
        115                 120                 125             


Thr Asp Thr Val Asp Val Ala Met Pro Leu Asn Phe Thr Gly Gly Gln 
    130                 135                 140                 


Leu His Ser Arg Met Phe Gln Asn Phe Pro Thr Glu Leu Leu Leu Ser 
145                 150                 155                 160 


Leu Ala Val Glu Pro Leu Thr Ala Asn Phe His Lys Trp Ser Leu Ser 
                165                 170                 175     


Val Lys Asn Phe Thr Met Asn Glu Lys Leu Lys Lys Phe Phe Asn Val 
            180                 185                 190         


Leu Thr Thr Asn Thr Asp Gly Lys Ile Glu Phe Ile Ser Thr Met Glu 
        195                 200                 205             


Gly Tyr Lys Tyr Pro Val Tyr Gly Val Gln Trp His Pro Glu Lys Ala 
    210                 215                 220                 


Pro Tyr Glu Trp Lys Asn Leu Asp Gly Ile Ser His Ala Pro Asn Ala 
225                 230                 235                 240 


Val Lys Thr Ala Phe Tyr Leu Ala Glu Phe Phe Val Asn Glu Ala Arg 
                245                 250                 255     


Lys Asn Asn His His Phe Lys Ser Glu Ser Glu Glu Glu Lys Ala Leu 
            260                 265                 270         


Ile Tyr Gln Phe Ser Pro Ile Tyr Thr Gly Asn Ile Ser Ser Phe Gln 
        275                 280                 285             


Gln Cys Tyr Ile Phe Asp 
    290                 


<210>  61
<211>  509
<212>  PRT
<213>  HOMO SAPIENS

<400>  61

Gly Phe Leu Tyr Pro Leu Val Asp Phe Cys Ile Ser Gly Lys Thr Arg 
1               5                   10                  15      


Gly Gln Lys Pro Asn Phe Val Ile Ile Leu Ala Asp Asp Met Gly Trp 
            20                  25                  30          


Gly Asp Leu Gly Ala Asn Trp Ala Glu Thr Lys Asp Thr Ala Asn Leu 
        35                  40                  45              


Asp Lys Met Ala Ser Glu Gly Met Arg Phe Val Asp Phe His Ala Ala 
    50                  55                  60                  


Ala Ser Thr Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Arg Leu 
65                  70                  75                  80  


Gly Leu Arg Asn Gly Val Thr Arg Asn Phe Ala Val Thr Ser Val Gly 
                85                  90                  95      


Gly Leu Pro Leu Asn Glu Thr Thr Leu Ala Glu Val Leu Gln Gln Ala 
            100                 105                 110         


Gly Tyr Val Thr Gly Ile Ile Gly Lys Trp His Leu Gly His His Gly 
        115                 120                 125             


Ser Tyr His Pro Asn Phe Arg Gly Phe Asp Tyr Tyr Phe Gly Ile Pro 
    130                 135                 140                 


Tyr Ser His Asp Met Gly Cys Thr Asp Thr Pro Gly Tyr Asn His Pro 
145                 150                 155                 160 


Pro Cys Pro Ala Cys Pro Gln Gly Asp Gly Pro Ser Arg Asn Leu Gln 
                165                 170                 175     


Arg Asp Cys Tyr Thr Asp Val Ala Leu Pro Leu Tyr Glu Asn Leu Asn 
            180                 185                 190         


Ile Val Glu Gln Pro Val Asn Leu Ser Ser Leu Ala Gln Lys Tyr Ala 
        195                 200                 205             


Glu Lys Ala Thr Gln Phe Ile Gln Arg Ala Ser Thr Ser Gly Arg Pro 
    210                 215                 220                 


Phe Leu Leu Tyr Val Ala Leu Ala His Met His Val Pro Leu Pro Val 
225                 230                 235                 240 


Thr Gln Leu Pro Ala Ala Pro Arg Gly Arg Ser Leu Tyr Gly Ala Gly 
                245                 250                 255     


Leu Trp Glu Met Asp Ser Leu Val Gly Gln Ile Lys Asp Lys Val Asp 
            260                 265                 270         


His Thr Val Lys Glu Asn Thr Phe Leu Trp Phe Thr Gly Asp Asn Gly 
        275                 280                 285             


Pro Trp Ala Gln Lys Cys Glu Leu Ala Gly Ser Val Gly Pro Phe Thr 
    290                 295                 300                 


Gly Phe Trp Gln Thr Arg Gln Gly Gly Ser Pro Ala Lys Gln Thr Thr 
305                 310                 315                 320 


Trp Glu Gly Gly His Arg Val Pro Ala Leu Ala Tyr Trp Pro Gly Arg 
                325                 330                 335     


Val Pro Val Asn Val Thr Ser Thr Ala Leu Leu Ser Val Leu Asp Ile 
            340                 345                 350         


Phe Pro Thr Val Val Ala Leu Ala Gln Ala Ser Leu Pro Gln Gly Arg 
        355                 360                 365             


Arg Phe Asp Gly Val Asp Val Ser Glu Val Leu Phe Gly Arg Ser Gln 
    370                 375                 380                 


Pro Gly His Arg Val Leu Phe His Pro Asn Ser Gly Ala Ala Gly Glu 
385                 390                 395                 400 


Phe Gly Ala Leu Gln Thr Val Arg Leu Glu Arg Tyr Lys Ala Phe Tyr 
                405                 410                 415     


Ile Thr Gly Gly Ala Arg Ala Cys Asp Gly Ser Thr Gly Pro Glu Leu 
            420                 425                 430         


Gln His Lys Phe Pro Leu Ile Phe Asn Leu Glu Asp Asp Thr Ala Glu 
        435                 440                 445             


Ala Val Pro Leu Glu Arg Gly Gly Ala Glu Tyr Gln Ala Val Leu Pro 
    450                 455                 460                 


Glu Val Arg Lys Val Leu Ala Asp Val Leu Gln Asp Ile Ala Asn Asp 
465                 470                 475                 480 


Asn Ile Ser Ser Ala Asp Tyr Thr Gln Asp Pro Ser Val Thr Pro Cys 
                485                 490                 495     


Cys Asn Pro Tyr Gln Ile Ala Cys Arg Cys Gln Ala Ala 
            500                 505                 


<210>  62
<211>  546
<212>  PRT
<213>  HOMO SAPIENS

<400>  62

Gln Asp Trp Lys Ala Glu Arg Ser Gln Asp Pro Phe Glu Lys Cys Met 
1               5                   10                  15      


Gln Asp Pro Asp Tyr Glu Gln Leu Leu Lys Val Val Thr Trp Gly Leu 
            20                  25                  30          


Asn Arg Thr Leu Lys Pro Gln Arg Val Ile Val Val Gly Ala Gly Val 
        35                  40                  45              


Ala Gly Leu Val Ala Ala Lys Val Leu Ser Asp Ala Gly His Lys Val 
    50                  55                  60                  


Thr Ile Leu Glu Ala Asp Asn Arg Ile Gly Gly Arg Ile Phe Thr Tyr 
65                  70                  75                  80  


Arg Asp Gln Asn Thr Gly Trp Ile Gly Glu Leu Gly Ala Met Arg Met 
                85                  90                  95      


Pro Ser Ser His Arg Ile Leu His Lys Leu Cys Gln Gly Leu Gly Leu 
            100                 105                 110         


Asn Leu Thr Lys Phe Thr Gln Tyr Asp Lys Asn Thr Trp Thr Glu Val 
        115                 120                 125             


His Glu Val Lys Leu Arg Asn Tyr Val Val Glu Lys Val Pro Glu Lys 
    130                 135                 140                 


Leu Gly Tyr Ala Leu Arg Pro Gln Glu Lys Gly His Ser Pro Glu Asp 
145                 150                 155                 160 


Ile Tyr Gln Met Ala Leu Asn Gln Ala Leu Lys Asp Leu Lys Ala Leu 
                165                 170                 175     


Gly Cys Arg Lys Ala Met Lys Lys Phe Glu Arg His Thr Leu Leu Glu 
            180                 185                 190         


Tyr Leu Leu Gly Glu Gly Asn Leu Ser Arg Pro Ala Val Gln Leu Leu 
        195                 200                 205             


Gly Asp Val Met Ser Glu Asp Gly Phe Phe Tyr Leu Ser Phe Ala Glu 
    210                 215                 220                 


Ala Leu Arg Ala His Ser Cys Leu Ser Asp Arg Leu Gln Tyr Ser Arg 
225                 230                 235                 240 


Ile Val Gly Gly Trp Asp Leu Leu Pro Arg Ala Leu Leu Ser Ser Leu 
                245                 250                 255     


Ser Gly Leu Val Leu Leu Asn Ala Pro Val Val Ala Met Thr Gln Gly 
            260                 265                 270         


Pro His Asp Val His Val Gln Ile Glu Thr Ser Pro Pro Ala Arg Asn 
        275                 280                 285             


Leu Lys Val Leu Lys Ala Asp Val Val Leu Leu Thr Ala Ser Gly Pro 
    290                 295                 300                 


Ala Val Lys Arg Ile Thr Phe Ser Pro Pro Leu Pro Arg His Met Gln 
305                 310                 315                 320 


Glu Ala Leu Arg Arg Leu His Tyr Val Pro Ala Thr Lys Val Phe Leu 
                325                 330                 335     


Ser Phe Arg Arg Pro Phe Trp Arg Glu Glu His Ile Glu Gly Gly His 
            340                 345                 350         


Ser Asn Thr Asp Arg Pro Ser Arg Met Ile Phe Tyr Pro Pro Pro Arg 
        355                 360                 365             


Glu Gly Ala Leu Leu Leu Ala Ser Tyr Thr Trp Ser Asp Ala Ala Ala 
    370                 375                 380                 


Ala Phe Ala Gly Leu Ser Arg Glu Glu Ala Leu Arg Leu Ala Leu Asp 
385                 390                 395                 400 


Asp Val Ala Ala Leu His Gly Pro Val Val Arg Gln Leu Trp Asp Gly 
                405                 410                 415     


Thr Gly Val Val Lys Arg Trp Ala Glu Asp Gln His Ser Gln Gly Gly 
            420                 425                 430         


Phe Val Val Gln Pro Pro Ala Leu Trp Gln Thr Glu Lys Asp Asp Trp 
        435                 440                 445             


Thr Val Pro Tyr Gly Arg Ile Tyr Phe Ala Gly Glu His Thr Ala Tyr 
    450                 455                 460                 


Pro His Gly Trp Val Glu Thr Ala Val Lys Ser Ala Leu Arg Ala Ala 
465                 470                 475                 480 


Ile Lys Ile Asn Ser Arg Lys Gly Pro Ala Ser Asp Thr Ala Ser Pro 
                485                 490                 495     


Glu Gly His Ala Ser Asp Met Glu Gly Gln Gly His Val His Gly Val 
            500                 505                 510         


Ala Ser Ser Pro Ser His Asp Leu Ala Lys Glu Glu Gly Ser His Pro 
        515                 520                 525             


Pro Val Gln Gly Gln Leu Ser Leu Gln Asn Thr Thr His Thr Arg Thr 
    530                 535                 540                 


Ser His 
545     


<210>  63
<211>  368
<212>  PRT
<213>  HOMO SAPIENS

<400>  63

Glu Asn Asp Phe Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu 
1               5                   10                  15      


Leu Trp Val Ser Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile 
            20                  25                  30          


Pro Leu Ile Thr Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu 
        35                  40                  45              


Ala Arg Lys Met Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu 
    50                  55                  60                  


Arg Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile 
65                  70                  75                  80  


Val Asn Asp Gly Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val 
                85                  90                  95      


Ser Asp Val Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala 
            100                 105                 110         


His Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys 
        115                 120                 125             


Asp Asp Gly Val Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile 
    130                 135                 140                 


Gly Thr Glu Val Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln 
145                 150                 155                 160 


Arg Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu 
                165                 170                 175     


Glu Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser 
            180                 185                 190         


Trp Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys 
        195                 200                 205             


Gln Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro 
    210                 215                 220                 


Asp Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys 
225                 230                 235                 240 


His Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg 
                245                 250                 255     


Pro Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala 
            260                 265                 270         


Ala Gly Ala Val Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro 
        275                 280                 285             


Ala His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser 
    290                 295                 300                 


Asn Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro 
305                 310                 315                 320 


Ser Gly Tyr Ser Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu 
                325                 330                 335     


Glu Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His 
            340                 345                 350         


Tyr Thr Glu Ser Ile Ser Val Ala Lys Ile Ser Val Tyr Gly Thr Leu 
        355                 360                 365             


<210>  64
<211>  416
<212>  PRT
<213>  HOMO SAPIENS

<400>  64

Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val Ile 
1               5                   10                  15      


Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp Ala 
            20                  25                  30          


Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu Gln 
        35                  40                  45              


Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn Pro 
    50                  55                  60                  


Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr Gln 
65                  70                  75                  80  


Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn Phe 
                85                  90                  95      


Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly Ser 
            100                 105                 110         


Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr Phe 
        115                 120                 125             


Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp Leu 
    130                 135                 140                 


His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His Lys 
145                 150                 155                 160 


Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly Ser 
                165                 170                 175     


Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr Ala 
            180                 185                 190         


Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys Arg 
        195                 200                 205             


Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp Ser 
    210                 215                 220                 


Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His Leu 
225                 230                 235                 240 


Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn Lys 
                245                 250                 255     


Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg Lys 
            260                 265                 270         


Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu Thr 
        275                 280                 285             


Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met Asn 
    290                 295                 300                 


Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln Arg 
305                 310                 315                 320 


His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile Val 
                325                 330                 335     


Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser Glu 
            340                 345                 350         


Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu His 
        355                 360                 365             


Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr Ala 
    370                 375                 380                 


Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr Pro 
385                 390                 395                 400 


Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His Tyr 
                405                 410                 415     


<210>  65
<211>  500
<212>  PRT
<213>  HOMO SAPIENS

<400>  65

Ile Gly Phe Arg Phe Ala Ser Tyr Ile Asn Asn Asp Met Val Leu Gln 
1               5                   10                  15      


Lys Glu Pro Ala Gly Ala Val Ile Trp Gly Phe Gly Thr Pro Gly Ala 
            20                  25                  30          


Thr Val Thr Val Thr Leu Arg Gln Gly Gln Glu Thr Ile Met Lys Lys 
        35                  40                  45              


Val Thr Ser Val Lys Ala His Ser Asp Thr Trp Met Val Val Leu Asp 
    50                  55                  60                  


Pro Met Lys Pro Gly Gly Pro Phe Glu Val Met Ala Gln Gln Thr Leu 
65                  70                  75                  80  


Glu Lys Ile Asn Phe Thr Leu Arg Val His Asp Val Leu Phe Gly Asp 
                85                  90                  95      


Val Trp Leu Cys Ser Gly Gln Ser Asn Met Gln Met Thr Val Leu Gln 
            100                 105                 110         


Ile Phe Asn Ala Thr Arg Glu Leu Ser Asn Thr Ala Ala Tyr Gln Ser 
        115                 120                 125             


Val Arg Ile Leu Ser Val Ser Pro Ile Gln Ala Glu Gln Glu Leu Glu 
    130                 135                 140                 


Asp Leu Val Ala Val Asp Leu Gln Trp Ser Lys Pro Thr Ser Glu Asn 
145                 150                 155                 160 


Leu Gly His Gly Tyr Phe Lys Tyr Met Ser Ala Val Cys Trp Leu Phe 
                165                 170                 175     


Gly Arg His Leu Tyr Asp Thr Leu Gln Tyr Pro Ile Gly Leu Ile Ala 
            180                 185                 190         


Ser Ser Trp Gly Gly Thr Pro Ile Glu Ala Trp Ser Ser Gly Arg Ser 
        195                 200                 205             


Leu Lys Ala Cys Gly Val Pro Lys Gln Gly Ser Ile Pro Tyr Asp Ser 
    210                 215                 220                 


Val Thr Gly Pro Ser Lys His Ser Val Leu Trp Asn Ala Met Ile His 
225                 230                 235                 240 


Pro Leu Cys Asn Met Thr Leu Lys Gly Val Val Trp Tyr Gln Gly Glu 
                245                 250                 255     


Ser Asn Ile Asn Tyr Asn Thr Asp Leu Tyr Asn Cys Thr Phe Pro Ala 
            260                 265                 270         


Leu Ile Glu Asp Trp Arg Glu Thr Phe His Arg Gly Ser Gln Gly Gln 
        275                 280                 285             


Thr Glu Arg Phe Phe Pro Phe Gly Leu Val Gln Leu Ser Ser Asp Leu 
    290                 295                 300                 


Ser Lys Lys Ser Ser Asp Asp Gly Phe Pro Gln Ile Arg Trp His Gln 
305                 310                 315                 320 


Thr Ala Asp Phe Gly Tyr Val Pro Asn Pro Lys Met Pro Asn Thr Phe 
                325                 330                 335     


Met Ala Val Ala Met Asp Leu Cys Asp Arg Asp Ser Pro Phe Gly Ser 
            340                 345                 350         


Ile His Pro Arg Asp Lys Gln Thr Val Ala Tyr Arg Leu His Leu Gly 
        355                 360                 365             


Ala Arg Ala Leu Ala Tyr Gly Glu Lys Asn Leu Thr Phe Glu Gly Pro 
    370                 375                 380                 


Leu Pro Glu Lys Ile Glu Leu Leu Ala His Lys Gly Leu Leu Asn Leu 
385                 390                 395                 400 


Thr Tyr Tyr Gln Gln Ile Gln Val Gln Lys Lys Asp Asn Lys Ile Phe 
                405                 410                 415     


Glu Ile Ser Cys Cys Ser Asp His Arg Cys Lys Trp Leu Pro Ala Ser 
            420                 425                 430         


Met Asn Thr Val Ser Thr Gln Ser Leu Thr Leu Ala Ile Asp Ser Cys 
        435                 440                 445             


His Gly Thr Val Val Ala Leu Arg Tyr Ala Trp Thr Thr Trp Pro Cys 
    450                 455                 460                 


Glu Tyr Lys Gln Cys Pro Leu Tyr His Pro Ser Ser Ala Leu Pro Ala 
465                 470                 475                 480 


Pro Pro Phe Ile Ala Phe Ile Thr Asp Gln Gly Pro Gly His Gln Ser 
                485                 490                 495     


Asn Val Ala Lys 
            500 


<210>  66
<211>  490
<212>  PRT
<213>  HOMO SAPIENS

<400>  66

Ser Leu Leu Arg Arg Leu Gly Glu His Ile Gln Gln Phe Gln Glu Ser 
1               5                   10                  15      


Ser Ala Gln Gly Leu Gly Leu Ser Leu Gly Pro Gly Ala Ala Ala Leu 
            20                  25                  30          


Pro Lys Val Gly Trp Leu Glu Gln Leu Leu Asp Pro Phe Asn Val Ser 
        35                  40                  45              


Asp Arg Arg Ser Phe Leu Gln Arg Tyr Trp Val Asn Asp Gln His Trp 
    50                  55                  60                  


Val Gly Gln Asp Gly Pro Ile Phe Leu His Leu Gly Gly Glu Gly Ser 
65                  70                  75                  80  


Leu Gly Pro Gly Ser Val Met Arg Gly His Pro Ala Ala Leu Ala Pro 
                85                  90                  95      


Ala Trp Gly Ala Leu Val Ile Ser Leu Glu His Arg Phe Tyr Gly Leu 
            100                 105                 110         


Ser Ile Pro Ala Gly Gly Leu Glu Met Ala Gln Leu Arg Phe Leu Ser 
        115                 120                 125             


Ser Arg Leu Ala Leu Ala Asp Val Val Ser Ala Arg Leu Ala Leu Ser 
    130                 135                 140                 


Arg Leu Phe Asn Ile Ser Ser Ser Ser Pro Trp Ile Cys Phe Gly Gly 
145                 150                 155                 160 


Ser Tyr Ala Gly Ser Leu Ala Ala Trp Ala Arg Leu Lys Phe Pro His 
                165                 170                 175     


Leu Ile Phe Ala Ser Val Ala Ser Ser Ala Pro Val Arg Ala Val Leu 
            180                 185                 190         


Asp Phe Ser Glu Tyr Asn Asp Val Val Ser Arg Ser Leu Met Ser Thr 
        195                 200                 205             


Ala Ile Gly Gly Ser Leu Glu Cys Arg Ala Ala Val Ser Val Ala Phe 
    210                 215                 220                 


Ala Glu Val Glu Arg Arg Leu Arg Ser Gly Gly Ala Ala Gln Ala Ala 
225                 230                 235                 240 


Leu Arg Thr Glu Leu Ser Ala Cys Gly Pro Leu Gly Arg Ala Glu Asn 
                245                 250                 255     


Gln Ala Glu Leu Leu Gly Ala Leu Gln Ala Leu Val Gly Gly Val Val 
            260                 265                 270         


Gln Tyr Asp Gly Gln Thr Gly Ala Pro Leu Ser Val Arg Gln Leu Cys 
        275                 280                 285             


Gly Leu Leu Leu Gly Gly Gly Gly Asn Arg Ser His Ser Thr Pro Tyr 
    290                 295                 300                 


Cys Gly Leu Arg Arg Ala Val Gln Ile Val Leu His Ser Leu Gly Gln 
305                 310                 315                 320 


Lys Cys Leu Ser Phe Ser Arg Ala Glu Thr Val Ala Gln Leu Arg Ser 
                325                 330                 335     


Thr Glu Pro Gln Leu Ser Gly Val Gly Asp Arg Gln Trp Leu Tyr Gln 
            340                 345                 350         


Thr Cys Thr Glu Phe Gly Phe Tyr Val Thr Cys Glu Asn Pro Arg Cys 
        355                 360                 365             


Pro Phe Ser Gln Leu Pro Ala Leu Pro Ser Gln Leu Asp Leu Cys Glu 
    370                 375                 380                 


Gln Val Phe Gly Leu Ser Ala Leu Ser Val Ala Gln Ala Val Ala Gln 
385                 390                 395                 400 


Thr Asn Ser Tyr Tyr Gly Gly Gln Thr Pro Gly Ala Asn Lys Val Leu 
                405                 410                 415     


Phe Val Asn Gly Asp Thr Asp Pro Trp His Val Leu Ser Val Thr Gln 
            420                 425                 430         


Ala Leu Gly Ser Ser Glu Ser Thr Leu Leu Ile Arg Thr Gly Ser His 
        435                 440                 445             


Cys Leu Asp Met Ala Pro Glu Arg Pro Ser Asp Ser Pro Ser Leu Arg 
    450                 455                 460                 


Leu Gly Arg Gln Asn Ile Phe Gln Gln Leu Gln Thr Trp Leu Lys Leu 
465                 470                 475                 480 


Ala Lys Glu Ser Gln Ile Lys Gly Glu Val 
                485                 490 


<210>  67
<211>  280
<212>  PRT
<213>  HOMO SAPIENS

<400>  67

Gly Leu Tyr Phe Arg Arg Gly Gln Thr Cys Tyr Arg Pro Leu Arg Gly 
1               5                   10                  15      


Asp Gly Leu Ala Pro Leu Gly Arg Ser Thr Tyr Pro Arg Pro His Glu 
            20                  25                  30          


Tyr Leu Ser Pro Ala Asp Leu Pro Lys Ser Trp Asp Trp Arg Asn Val 
        35                  40                  45              


Asp Gly Val Asn Tyr Ala Ser Ile Thr Arg Asn Gln His Ile Pro Gln 
    50                  55                  60                  


Tyr Cys Gly Ser Cys Trp Ala His Ala Ser Thr Ser Ala Met Ala Asp 
65                  70                  75                  80  


Arg Ile Asn Ile Lys Arg Lys Gly Ala Trp Pro Ser Thr Leu Leu Ser 
                85                  90                  95      


Val Gln Asn Val Ile Asp Cys Gly Asn Ala Gly Ser Cys Glu Gly Gly 
            100                 105                 110         


Asn Asp Leu Ser Val Trp Asp Tyr Ala His Gln His Gly Ile Pro Asp 
        115                 120                 125             


Glu Thr Cys Asn Asn Tyr Gln Ala Lys Asp Gln Glu Cys Asp Lys Phe 
    130                 135                 140                 


Asn Gln Cys Gly Thr Cys Asn Glu Phe Lys Glu Cys His Ala Ile Arg 
145                 150                 155                 160 


Asn Tyr Thr Leu Trp Arg Val Gly Asp Tyr Gly Ser Leu Ser Gly Arg 
                165                 170                 175     


Glu Lys Met Met Ala Glu Ile Tyr Ala Asn Gly Pro Ile Ser Cys Gly 
            180                 185                 190         


Ile Met Ala Thr Glu Arg Leu Ala Asn Tyr Thr Gly Gly Ile Tyr Ala 
        195                 200                 205             


Glu Tyr Gln Asp Thr Thr Tyr Ile Asn His Val Val Ser Val Ala Gly 
    210                 215                 220                 


Trp Gly Ile Ser Asp Gly Thr Glu Tyr Trp Ile Val Arg Asn Ser Trp 
225                 230                 235                 240 


Gly Glu Pro Trp Gly Glu Arg Gly Trp Leu Arg Ile Val Thr Ser Thr 
                245                 250                 255     


Tyr Lys Asp Gly Lys Gly Ala Arg Tyr Asn Leu Ala Ile Glu Glu His 
            260                 265                 270         


Cys Thr Phe Gly Asp Pro Ile Val 
        275                 280 


<210>  68
<211>  465
<212>  PRT
<213>  HOMO SAPIENS

<400>  68

Ala Pro Ala Gln Pro Arg Ala Ala Ser Phe Gln Ala Trp Gly Pro Pro 
1               5                   10                  15      


Ser Pro Glu Leu Leu Ala Pro Thr Arg Phe Ala Leu Glu Met Phe Asn 
            20                  25                  30          


Arg Gly Arg Ala Ala Gly Thr Arg Ala Val Leu Gly Leu Val Arg Gly 
        35                  40                  45              


Arg Val Arg Arg Ala Gly Gln Gly Ser Leu Tyr Ser Leu Glu Ala Thr 
    50                  55                  60                  


Leu Glu Glu Pro Pro Cys Asn Asp Pro Met Val Cys Arg Leu Pro Val 
65                  70                  75                  80  


Ser Lys Lys Thr Leu Leu Cys Ser Phe Gln Val Leu Asp Glu Leu Gly 
                85                  90                  95      


Arg His Val Leu Leu Arg Lys Asp Cys Gly Pro Val Asp Thr Lys Val 
            100                 105                 110         


Pro Gly Ala Gly Glu Pro Lys Ser Ala Phe Thr Gln Gly Ser Ala Met 
        115                 120                 125             


Ile Ser Ser Leu Ser Gln Asn His Pro Asp Asn Arg Asn Glu Thr Phe 
    130                 135                 140                 


Ser Ser Val Ile Ser Leu Leu Asn Glu Asp Pro Leu Ser Gln Asp Leu 
145                 150                 155                 160 


Pro Val Lys Met Ala Ser Ile Phe Lys Asn Phe Val Ile Thr Tyr Asn 
                165                 170                 175     


Arg Thr Tyr Glu Ser Lys Glu Glu Ala Arg Trp Arg Leu Ser Val Phe 
            180                 185                 190         


Val Asn Asn Met Val Arg Ala Gln Lys Ile Gln Ala Leu Asp Arg Gly 
        195                 200                 205             


Thr Ala Gln Tyr Gly Val Thr Lys Phe Ser Asp Leu Thr Glu Glu Glu 
    210                 215                 220                 


Phe Arg Thr Ile Tyr Leu Asn Thr Leu Leu Arg Lys Glu Pro Gly Asn 
225                 230                 235                 240 


Lys Met Lys Gln Ala Lys Ser Val Gly Asp Leu Ala Pro Pro Glu Trp 
                245                 250                 255     


Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val Lys Asp Gln Gly Met 
            260                 265                 270         


Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly Asn Val Glu Gly Gln 
        275                 280                 285             


Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu Ser Glu Gln Glu Leu 
    290                 295                 300                 


Leu Asp Cys Asp Lys Met Asp Lys Ala Cys Met Gly Gly Leu Pro Ser 
305                 310                 315                 320 


Asn Ala Tyr Ser Ala Ile Lys Asn Leu Gly Gly Leu Glu Thr Glu Asp 
                325                 330                 335     


Asp Tyr Ser Tyr Gln Gly His Met Gln Ser Cys Asn Phe Ser Ala Glu 
            340                 345                 350         


Lys Ala Lys Val Tyr Ile Asn Asp Ser Val Glu Leu Ser Gln Asn Glu 
        355                 360                 365             


Gln Lys Leu Ala Ala Trp Leu Ala Lys Arg Gly Pro Ile Ser Val Ala 
    370                 375                 380                 


Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His Gly Ile Ser Arg Pro 
385                 390                 395                 400 


Leu Arg Pro Leu Cys Ser Pro Trp Leu Ile Asp His Ala Val Leu Leu 
                405                 410                 415     


Val Gly Tyr Gly Asn Arg Ser Asp Val Pro Phe Trp Ala Ile Lys Asn 
            420                 425                 430         


Ser Trp Gly Thr Asp Trp Gly Glu Lys Gly Tyr Tyr Tyr Leu His Arg 
        435                 440                 445             


Gly Ser Gly Ala Cys Gly Val Asn Thr Met Ala Ser Ser Ala Val Val 
    450                 455                 460                 


Asp 
465 


<210>  69
<211>  478
<212>  PRT
<213>  HOMO SAPIENS

<400>  69

Ala Glu Leu Arg Ala Pro Pro Asp Lys Ile Ala Ile Ile Gly Ala Gly 
1               5                   10                  15      


Ile Gly Gly Thr Ser Ala Ala Tyr Tyr Leu Arg Gln Lys Phe Gly Lys 
            20                  25                  30          


Asp Val Lys Ile Asp Leu Phe Glu Arg Glu Glu Val Gly Gly Arg Leu 
        35                  40                  45              


Ala Thr Met Met Val Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val 
    50                  55                  60                  


Ile His Pro Leu Asn Leu His Met Lys Arg Phe Val Lys Asp Leu Gly 
65                  70                  75                  80  


Leu Ser Ala Val Gln Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly 
                85                  90                  95      


Glu Thr Leu Val Phe Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile 
            100                 105                 110         


Lys Leu Val Trp Arg Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp 
        115                 120                 125             


Val Glu Asp Val Leu Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser 
    130                 135                 140                 


His Asp Tyr Ala Phe Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly 
145                 150                 155                 160 


Gly Asp Asp Phe Leu Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu 
                165                 170                 175     


Gln Lys Ala Gly Phe Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro 
            180                 185                 190         


Val Met Arg Val Asn Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val 
        195                 200                 205             


Gly Ala Val Ser Leu Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu 
    210                 215                 220                 


Gly Gly Asn Lys Leu Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser 
225                 230                 235                 240 


Asn Leu Ile Ser Gly Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr 
                245                 250                 255     


Lys Tyr Thr Gly Asn Pro Thr Lys Met Tyr Glu Val Val Tyr Gln Ile 
            260                 265                 270         


Gly Thr Glu Thr Arg Ser Asp Phe Tyr Asp Ile Val Leu Val Ala Thr 
        275                 280                 285             


Pro Leu Asn Arg Lys Met Ser Asn Ile Thr Phe Leu Asn Phe Asp Pro 
    290                 295                 300                 


Pro Ile Glu Glu Phe His Gln Tyr Tyr Gln His Ile Val Thr Thr Leu 
305                 310                 315                 320 


Val Lys Gly Glu Leu Asn Thr Ser Ile Phe Ser Ser Arg Pro Ile Asp 
                325                 330                 335     


Lys Phe Gly Leu Asn Thr Val Leu Thr Thr Asp Asn Ser Asp Leu Phe 
            340                 345                 350         


Ile Asn Ser Ile Gly Ile Val Pro Ser Val Arg Glu Lys Glu Asp Pro 
        355                 360                 365             


Glu Pro Ser Thr Asp Gly Thr Tyr Val Trp Lys Ile Phe Ser Gln Glu 
    370                 375                 380                 


Thr Leu Thr Lys Ala Gln Ile Leu Lys Leu Phe Leu Ser Tyr Asp Tyr 
385                 390                 395                 400 


Ala Val Lys Lys Pro Trp Leu Ala Tyr Pro His Tyr Lys Pro Pro Glu 
                405                 410                 415     


Lys Cys Pro Ser Ile Ile Leu His Asp Arg Leu Tyr Tyr Leu Asn Gly 
            420                 425                 430         


Ile Glu Cys Ala Ala Ser Ala Met Glu Met Ser Ala Ile Ala Ala His 
        435                 440                 445             


Asn Ala Ala Leu Leu Ala Tyr His Arg Trp Asn Gly His Thr Asp Met 
    450                 455                 460                 


Ile Asp Gln Asp Gly Leu Tyr Glu Lys Leu Lys Thr Glu Leu 
465                 470                 475             


<210>  70
<211>  471
<212>  PRT
<213>  HOMO SAPIENS

<400>  70

Gly Ala Arg Arg Ala Pro Asp Pro Gly Phe Gln Glu Arg Phe Phe Gln 
1               5                   10                  15      


Gln Arg Leu Asp His Phe Asn Phe Glu Arg Phe Gly Asn Lys Thr Phe 
            20                  25                  30          


Pro Gln Arg Phe Leu Val Ser Asp Arg Phe Trp Val Arg Gly Glu Gly 
        35                  40                  45              


Pro Ile Phe Phe Tyr Thr Gly Asn Glu Gly Asp Val Trp Ala Phe Ala 
    50                  55                  60                  


Asn Asn Ser Ala Phe Val Ala Glu Leu Ala Ala Glu Arg Gly Ala Leu 
65                  70                  75                  80  


Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Lys Ser Leu Pro Phe Gly 
                85                  90                  95      


Ala Gln Ser Thr Gln Arg Gly His Thr Glu Leu Leu Thr Val Glu Gln 
            100                 105                 110         


Ala Leu Ala Asp Phe Ala Glu Leu Leu Arg Ala Leu Arg Arg Asp Leu 
        115                 120                 125             


Gly Ala Gln Asp Ala Pro Ala Ile Ala Phe Gly Gly Ser Tyr Gly Gly 
    130                 135                 140                 


Met Leu Ser Ala Tyr Leu Arg Met Lys Tyr Pro His Leu Val Ala Gly 
145                 150                 155                 160 


Ala Leu Ala Ala Ser Ala Pro Val Leu Ala Val Ala Gly Leu Gly Asp 
                165                 170                 175     


Ser Asn Gln Phe Phe Arg Asp Val Thr Ala Asp Phe Glu Gly Gln Ser 
            180                 185                 190         


Pro Lys Cys Thr Gln Gly Val Arg Glu Ala Phe Arg Gln Ile Lys Asp 
        195                 200                 205             


Leu Phe Leu Gln Gly Ala Tyr Asp Thr Val Arg Trp Glu Phe Gly Thr 
    210                 215                 220                 


Cys Gln Pro Leu Ser Asp Glu Lys Asp Leu Thr Gln Leu Phe Met Phe 
225                 230                 235                 240 


Ala Arg Asn Ala Phe Thr Val Leu Ala Met Met Asp Tyr Pro Tyr Pro 
                245                 250                 255     


Thr Asp Phe Leu Gly Pro Leu Pro Ala Asn Pro Val Lys Val Gly Cys 
            260                 265                 270         


Asp Arg Leu Leu Ser Glu Ala Gln Arg Ile Thr Gly Leu Arg Ala Leu 
        275                 280                 285             


Ala Gly Leu Val Tyr Asn Ala Ser Gly Ser Glu His Cys Tyr Asp Ile 
    290                 295                 300                 


Tyr Arg Leu Tyr His Ser Cys Ala Asp Pro Thr Gly Cys Gly Thr Gly 
305                 310                 315                 320 


Pro Asp Ala Arg Ala Trp Asp Tyr Gln Ala Cys Thr Glu Ile Asn Leu 
                325                 330                 335     


Thr Phe Ala Ser Asn Asn Val Thr Asp Met Phe Pro Asp Leu Pro Phe 
            340                 345                 350         


Thr Asp Glu Leu Arg Gln Arg Tyr Cys Leu Asp Thr Trp Gly Val Trp 
        355                 360                 365             


Pro Arg Pro Asp Trp Leu Leu Thr Ser Phe Trp Gly Gly Asp Leu Arg 
    370                 375                 380                 


Ala Ala Ser Asn Ile Ile Phe Ser Asn Gly Asn Leu Asp Pro Trp Ala 
385                 390                 395                 400 


Gly Gly Gly Ile Arg Arg Asn Leu Ser Ala Ser Val Ile Ala Val Thr 
                405                 410                 415     


Ile Gln Gly Gly Ala His His Leu Asp Leu Arg Ala Ser His Pro Glu 
            420                 425                 430         


Asp Pro Ala Ser Val Val Glu Ala Arg Lys Leu Glu Ala Thr Ile Ile 
        435                 440                 445             


Gly Glu Trp Val Lys Ala Ala Arg Arg Glu Gln Gln Pro Ala Leu Arg 
    450                 455                 460                 


Gly Gly Pro Arg Leu Ser Leu 
465                 470     


<210>  71
<211>  275
<212>  PRT
<213>  HOMO SAPIENS

<400>  71

Ala Pro Ala Pro His Arg Ala Ser Tyr Lys Pro Val Ile Val Val His 
1               5                   10                  15      


Gly Leu Phe Asp Ser Ser Tyr Ser Phe Arg His Leu Leu Glu Tyr Ile 
            20                  25                  30          


Asn Glu Thr His Pro Gly Thr Val Val Thr Val Leu Asp Leu Phe Asp 
        35                  40                  45              


Gly Arg Glu Ser Leu Arg Pro Leu Trp Glu Gln Val Gln Gly Phe Arg 
    50                  55                  60                  


Glu Ala Val Val Pro Ile Met Ala Lys Ala Pro Gln Gly Val His Leu 
65                  70                  75                  80  


Ile Cys Tyr Ser Gln Gly Gly Leu Val Cys Arg Ala Leu Leu Ser Val 
                85                  90                  95      


Met Asp Asp His Asn Val Asp Ser Phe Ile Ser Leu Ser Ser Pro Gln 
            100                 105                 110         


Met Gly Gln Tyr Gly Asp Thr Asp Tyr Leu Lys Trp Leu Phe Pro Thr 
        115                 120                 125             


Ser Met Arg Ser Asn Leu Tyr Arg Ile Cys Tyr Ser Pro Trp Gly Gln 
    130                 135                 140                 


Glu Phe Ser Ile Cys Asn Tyr Trp His Asp Pro His His Asp Asp Leu 
145                 150                 155                 160 


Tyr Leu Asn Ala Ser Ser Phe Leu Ala Leu Ile Asn Gly Glu Arg Asp 
                165                 170                 175     


His Pro Asn Ala Thr Val Trp Arg Lys Asn Phe Leu Arg Val Gly His 
            180                 185                 190         


Leu Val Leu Ile Gly Gly Pro Asp Asp Gly Val Ile Thr Pro Trp Gln 
        195                 200                 205             


Ser Ser Phe Phe Gly Phe Tyr Asp Ala Asn Glu Thr Val Leu Glu Met 
    210                 215                 220                 


Glu Glu Gln Leu Val Tyr Leu Arg Asp Ser Phe Gly Leu Lys Thr Leu 
225                 230                 235                 240 


Leu Ala Arg Gly Ala Ile Val Arg Cys Pro Met Ala Gly Ile Ser His 
                245                 250                 255     


Thr Ala Trp His Ser Asn Arg Thr Leu Tyr Glu Thr Cys Ile Glu Pro 
            260                 265                 270         


Trp Leu Ser 
        275 


<210>  72
<211>  508
<212>  PRT
<213>  HOMO SAPIENS

<400>  72

Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro Leu His Leu 
1               5                   10                  15      


Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn Leu Ala Thr 
            20                  25                  30          


Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu Arg Thr Leu 
        35                  40                  45              


Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly Thr Lys Thr 
    50                  55                  60                  


Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe Glu Glu Arg 
65                  70                  75                  80  


Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys Tyr Gly Ser 
                85                  90                  95      


Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp Pro Tyr Gln 
            100                 105                 110         


Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe Lys Asn Ser 
        115                 120                 125             


Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe Ala Asn Cys 
    130                 135                 140                 


Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu Arg Thr Ala 
145                 150                 155                 160 


Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu Asp Tyr Cys 
                165                 170                 175     


Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn Glu Pro Asn 
            180                 185                 190         


Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser Gln Leu Gly 
        195                 200                 205             


Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser Thr Phe Lys 
    210                 215                 220                 


Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg Arg Lys Thr 
225                 230                 235                 240 


Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu Val Ile Asp 
                245                 250                 255     


Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr Ala Thr Lys 
            260                 265                 270         


Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile Ser Ser Val 
        275                 280                 285             


Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly Lys Lys Val 
    290                 295                 300                 


Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala Pro Leu Leu 
305                 310                 315                 320 


Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys Leu Gly Leu 
                325                 330                 335     


Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val Phe Phe Gly 
            340                 345                 350         


Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro Leu Pro Asp 
        355                 360                 365             


Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr Lys Val Leu 
    370                 375                 380                 


Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg Val Tyr Leu 
385                 390                 395                 400 


His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly Asp Leu Thr 
                405                 410                 415     


Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu Arg Leu Pro 
            420                 425                 430         


Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu Arg Pro Leu 
        435                 440                 445             


Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn Gly Leu Thr 
    450                 455                 460                 


Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met Glu Lys Pro 
465                 470                 475                 480 


Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser Tyr Ser Phe 
                485                 490                 495     


Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
            500                 505             


<210>  73
<211>  452
<212>  PRT
<213>  HOMO SAPIENS

<400>  73

Lys Ala Ile Cys Lys Asn Gly Ile Ser Lys Arg Thr Phe Glu Glu Ile 
1               5                   10                  15      


Lys Glu Glu Ile Ala Ser Cys Gly Asp Val Ala Lys Ala Ile Ile Asn 
            20                  25                  30          


Leu Ala Val Tyr Gly Lys Ala Gln Asn Arg Ser Tyr Glu Arg Leu Ala 
        35                  40                  45              


Leu Leu Val Asp Thr Val Gly Pro Arg Leu Ser Gly Ser Lys Asn Leu 
    50                  55                  60                  


Glu Lys Ala Ile Gln Ile Met Tyr Gln Asn Leu Gln Gln Asp Gly Leu 
65                  70                  75                  80  


Glu Lys Val His Leu Glu Pro Val Arg Ile Pro His Trp Glu Arg Gly 
                85                  90                  95      


Glu Glu Ser Ala Val Met Leu Glu Pro Arg Ile His Lys Ile Ala Ile 
            100                 105                 110         


Leu Gly Leu Gly Ser Ser Ile Gly Thr Pro Pro Glu Gly Ile Thr Ala 
        115                 120                 125             


Glu Val Leu Val Val Thr Ser Phe Asp Glu Leu Gln Arg Arg Ala Ser 
    130                 135                 140                 


Glu Ala Arg Gly Lys Ile Val Val Tyr Asn Gln Pro Tyr Ile Asn Tyr 
145                 150                 155                 160 


Ser Arg Thr Val Gln Tyr Arg Thr Gln Gly Ala Val Glu Ala Ala Lys 
                165                 170                 175     


Val Gly Ala Leu Ala Ser Leu Ile Arg Ser Val Ala Ser Phe Ser Ile 
            180                 185                 190         


Tyr Ser Pro His Thr Gly Ile Gln Glu Tyr Gln Asp Gly Val Pro Lys 
        195                 200                 205             


Ile Pro Thr Ala Cys Ile Thr Val Glu Asp Ala Glu Met Met Ser Arg 
    210                 215                 220                 


Met Ala Ser His Gly Ile Lys Ile Val Ile Gln Leu Lys Met Gly Ala 
225                 230                 235                 240 


Lys Thr Tyr Pro Asp Thr Asp Ser Phe Asn Thr Val Ala Glu Ile Thr 
                245                 250                 255     


Gly Ser Lys Tyr Pro Glu Gln Val Val Leu Val Ser Gly His Leu Asp 
            260                 265                 270         


Ser Trp Asp Val Gly Gln Gly Ala Met Asp Asp Gly Gly Gly Ala Phe 
        275                 280                 285             


Ile Ser Trp Glu Ala Leu Ser Leu Ile Lys Asp Leu Gly Leu Arg Pro 
    290                 295                 300                 


Lys Arg Thr Leu Arg Leu Val Leu Trp Thr Ala Glu Glu Gln Gly Gly 
305                 310                 315                 320 


Val Gly Ala Phe Gln Tyr Tyr Gln Leu His Lys Val Asn Ile Ser Asn 
                325                 330                 335     


Tyr Ser Leu Val Met Glu Ser Asp Ala Gly Thr Phe Leu Pro Thr Gly 
            340                 345                 350         


Leu Gln Phe Thr Gly Ser Glu Lys Ala Arg Ala Ile Met Glu Glu Val 
        355                 360                 365             


Met Ser Leu Leu Gln Pro Leu Asn Ile Thr Gln Val Leu Ser His Gly 
    370                 375                 380                 


Glu Gly Thr Asp Ile Asn Phe Trp Ile Gln Ala Gly Val Pro Gly Ala 
385                 390                 395                 400 


Ser Leu Leu Asp Asp Leu Tyr Lys Tyr Phe Phe Phe His His Ser His 
                405                 410                 415     


Gly Asp Thr Met Thr Val Met Asp Pro Lys Gln Met Asn Val Ala Ala 
            420                 425                 430         


Ala Val Trp Ala Val Val Ser Tyr Val Val Ala Asp Met Glu Glu Met 
        435                 440                 445             


Leu Pro Arg Ser 
    450         


<210>  74
<211>  341
<212>  PRT
<213>  HOMO SAPIENS

<400>  74

Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala Gly Ser Leu Ala Gly Ser 
1               5                   10                  15      


Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ala His Gly Ser Ser Ala 
            20                  25                  30          


Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly Pro Val Pro 
        35                  40                  45              


Gly Glu Arg Gln Leu Ala His Ser Lys Met Val Pro Ile Pro Ala Gly 
    50                  55                  60                  


Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly Glu 
65                  70                  75                  80  


Ala Pro Ala Arg Arg Val Thr Ile Asp Ala Phe Tyr Met Asp Ala Tyr 
                85                  90                  95      


Glu Val Ser Asn Thr Glu Phe Glu Lys Phe Val Asn Ser Thr Gly Tyr 
            100                 105                 110         


Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly Met 
        115                 120                 125             


Leu Ser Glu Gln Val Lys Thr Asn Ile Gln Gln Ala Val Ala Ala Ala 
    130                 135                 140                 


Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu Gly 
145                 150                 155                 160 


Pro Asp Ser Thr Ile Leu His Arg Pro Asp His Pro Val Leu His Val 
                165                 170                 175     


Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg Leu 
            180                 185                 190         


Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu His Asn 
        195                 200                 205             


Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln His Tyr 
    210                 215                 220                 


Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Gly Glu Asp 
225                 230                 235                 240 


Gly Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly Tyr 
                245                 250                 255     


Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp Trp 
            260                 265                 270         


Trp Thr Val His His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly Pro 
        275                 280                 285             


Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys His 
    290                 295                 300                 


Arg Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn Thr 
305                 310                 315                 320 


Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp Arg 
                325                 330                 335     


Leu Pro Thr Met Asp 
            340     


