                         SEQUENCE LISTING

<110>  MEDIMMUNE LTD
 
<120>  COMPOSITIONS AND METHODS FOR INHIBITING CANCER STEM CELLS

<130>  LOX1-200EP1

<150>  US 62/235,144
<151>  2015-09-30

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox514 CDR-1 Heavy Chain sequence

<400>  1

Glu Leu Ser Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140110 CDR-2 Heavy Chain sequence

<400>  2

Gly Phe Asp Pro Glu Asp Phe Lys Tyr His Thr His Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140110 CDR-3 Heavy Chain sequence

<400>  3

Val Trp Gly Thr Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  4
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140110 Heavy Chain sequence

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Phe Lys Tyr His Thr His Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Val Trp Gly Thr Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox514 CDR-2 Heavy Chain sequence

<400>  5

Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140011 CDR-2 Heavy Chain sequence

<400>  6

Gly Phe Asp Pro Glu Asp Trp Glu Tyr Ala Tyr Asp Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140014 CDR-2 Heavy Chain sequence

<400>  7

Gly Phe Asp Pro Glu Asp Tyr Thr Ile Arg Val Gly Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140016 CDR-2 Heavy Chain sequence

<400>  8

Gly Phe Asp Pro Glu Asp Trp Gln Thr His Thr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140038 CDR-2 Heavy Chain sequence

<400>  9

Gly Phe Asp Pro Glu Asp Trp Thr Ile His Val Asp Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140094 CDR-2 Heavy Chain sequence

<400>  10

Gly Phe Asp Pro Glu Asp Trp Gln Tyr His Val Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140108 CDR-2 Heavy Chain sequence

<400>  11

Gly Phe Asp Pro Glu Asp Trp Ser Asn His Val Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140092 CDR-2 Heavy Chain sequence

<400>  12

Gly Phe Asp Pro Glu Asp Trp Lys Tyr His Leu Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140093 CDR-2 Heavy Chain sequence

<400>  13

Gly Phe Asp Pro Glu Asp Trp Ala Tyr His Gln Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140011 CDR-3 Heavy Chain sequence

<400>  14

Pro Asn Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140108 CDR-3 Heavy Chain sequence

<400>  15

Ser Thr Gly Arg Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140092_D CDR-3 Heavy Chain sequence

<400>  16

Pro Asp Gly Thr His Gln Gly Gly Val Arg Gly Trp Asp Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140092_N CDR-3 Heavy Chain sequence

<400>  17

Pro Asn Gly Thr His Gln Gly Gly Val Arg Gly Trp Asp Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140093_D CDR-3 Heavy Chain sequence

<400>  18

Pro Asp Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  19
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140011 Heavy Chain sequence

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Trp Glu Tyr Ala Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asn Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  20
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140014 Heavy Chain sequence

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Tyr Thr Ile Arg Val Gly Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asn Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  21
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140016 Heavy Chain sequence

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Trp Gln Thr His Thr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asn Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  22
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140038 Heavy Chain sequence

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Trp Thr Ile His Val Asp Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asn Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  23
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140094 Heavy Chain sequence

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Trp Gln Tyr His Val Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asn Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  24
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140108 Heavy Chain sequence

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Trp Ser Asn His Val Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Thr Ser Thr Gly Arg Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  25
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140092_D Heavy Chain sequence

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Trp Lys Tyr His Leu Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asp Gly Thr His Gln Gly Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  26
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140092_N Heavy Chain sequence

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Trp Lys Tyr His Leu Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asn Gly Thr His Gln Gly Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  27
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140093_D Heavy Chain sequence

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Trp Ala Tyr His Gln Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asp Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  28
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140093_N Heavy Chain sequence

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Trp Ala Tyr His Gln Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asn Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  29
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox514 Heavy Chain sequence

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Asn Gly Gln Gln Gly Lys Gly Val Arg Gly Trp Asp Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Arg Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox514 CDR-1 Light Chain sequence

<400>  30

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox514 CDR-2 Light Chain sequence

<400>  31

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox514 CDR-3 Light Chain sequence

<400>  32

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  33
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140110 Light Chain sequence

<400>  33

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140094 CDR-3 Light Chain sequence

<400>  34

Gln Ser Tyr Asp Ser Met Tyr Arg Phe Gly 
1               5                   10  


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140093 CDR-3 Light Chain sequence

<400>  35

Gln Ser Tyr Asp Ser Ser His Arg Ala Trp Ala 
1               5                   10      


<210>  36
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140094 Light Chain sequence

<400>  36

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Met 
                85                  90                  95      


Tyr Arg Phe Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  37
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX5140093 Light Chain sequence

<400>  37

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


His Arg Ala Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 CDR-1 Heavy Chain sequence

<400>  38

Asp Tyr Ala Met His 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 CDR-2 Heavy Chain sequence

<400>  39

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_G82bS_gl CDR-3 Heavy Chain sequence

<400>  40

Glu Gly Ser Trp Asn Tyr Asp Ala Leu Asp Ile 
1               5                   10      


<210>  41
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_G82bS_gl Heavy Chain sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Trp Asn Tyr Asp Ala Leu Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960067_ngl1 CDR-2 Heavy Chain sequence

<400>  42

Gly Val Ser Leu Gln Glu Leu Tyr Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960086_ngl1 CDR-2 Heavy Chain sequence

<400>  43

Gly Ile Ser Trp Asn Ser Pro Asp Arg Tyr Met Asp Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 CDR-3 Heavy Chain sequence

<400>  44

Glu Gly Asn Trp Asn Tyr Asp Ala Phe Asp Ile 
1               5                   10      


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960067_ngl1 CDR-3 Heavy Chain sequence

<400>  45

Glu Gly Ser Trp Asn Tyr Asp Ala Phe Asp Ile 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_ngl1 CDR-3 Heavy Chain sequence

<400>  46

Glu Gly Ser Trp Asn Tyr Asp Ala Leu Asp Ile 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960101_ngl1 CDR-3 Heavy Chain sequence

<400>  47

Glu Gly Asn Trp Asn Tyr Asp Ala Phe Asp Val 
1               5                   10      


<210>  48
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960067_ngl1 Heavy Chain sequence

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Leu Gln Glu Leu Tyr Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Gly Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Trp Asn Tyr Asp Ala Phe Asp Ile Trp Gly Arg 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  49
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960071_ngl1 Heavy Chain sequence

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Trp Asn Tyr Asp Ala Phe Asp Ile Trp Gly Arg 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  50
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_ngl1 Heavy Chain sequence

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Trp Asn Tyr Asp Ala Leu Asp Ile Trp Gly Arg 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  51
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960086_ngl1 Heavy Chain sequence

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Pro Asp Arg Tyr Met Asp Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Trp Asn Tyr Asp Ala Phe Asp Ile Trp Gly Arg 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  52
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960101_ngl1 Heavy Chain sequence

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Trp Asn Tyr Asp Ala Phe Asp Val Trp Gly Arg 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  53
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_gl Heavy Chain sequence

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Trp Asn Tyr Asp Ala Leu Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  54
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 Heavy Chain sequence

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Trp Asn Tyr Asp Ala Phe Asp Ile Trp Gly Arg 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_G82bS_gl CDR-1 Light Chain sequence

<400>  55

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_G82bS_gl CDR-2 Light Chain sequence

<400>  56

Asp Val Ser Lys Arg Pro Ser 
1               5           


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_G82bS_gl CDR-3 Light Chain sequence

<400>  57

Met Gly Gly Met Gly Arg Ser Thr Asn Trp Val 
1               5                   10      


<210>  58
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_G82bS_gl Light Chain sequence

<400>  58

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Pro Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Met Gly Gly Met Gly Arg 
                85                  90                  95      


Ser Thr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  59
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960116_ngl1 CDR-1 Light Chain sequence

<400>  59

Thr Gly Thr Ser Asn Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 CDR-2 Light Chain sequence

<400>  60

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 CDR-3 Light Chain sequence

<400>  61

Ser Ser Tyr Thr Ser Ser Ser Thr Asn Trp Val 
1               5                   10      


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960067_ngl1 CDR-3 Light Chain sequence

<400>  62

Leu Gly Arg Thr Trp Ser Ser Thr Asn Trp Val 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960071_ngl1 CDR-3 Light Chain sequence

<400>  63

Met Gly Ser Met Gly Arg Ser Thr Asn Trp Val 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960094_ngl1 CDR-3 Light Chain sequence

<400>  64

Ala Gln Arg Thr Val Ser Ser Thr Asn Trp Val 
1               5                   10      


<210>  65
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960067_ngl1 Light Chain sequence

<400>  65

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Gly Arg Thr Trp Ser 
                85                  90                  95      


Ser Thr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  66
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960071_ngl1 Light Chain sequence

<400>  66

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Pro Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Met Gly Ser Met Gly Arg 
                85                  90                  95      


Ser Thr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  67
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960073_ngl1 Light Chain sequence

<400>  67

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Pro Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Met Gly Gly Met Gly Arg 
                85                  90                  95      


Ser Thr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  68
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960094_ngl1 Light Chain sequence

<400>  68

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Gln Arg Thr Val Ser 
                85                  90                  95      


Ser Thr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  69
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LX6960116_ngl1 Light Chain sequence

<400>  69

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Met Gly Ser Met Gly Arg 
                85                  90                  95      


Ser Thr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  70
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 Light Chain sequence

<400>  70

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox514 VH CDR2


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Gly, Trp, Tyr, or Phe

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Glu, Thr, Gln, Ser, Lys, or Ala

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Thr, Tyr, Ile, or Asn

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Ile, Ala, Arg, or His

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Tyr, Val, Thr, Leu, or Gln

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is Ala, Asp, Gly, Ser, or His

<400>  71

Gly Phe Asp Pro Glu Asp Xaa Xaa Xaa Xaa Xaa Xaa Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox514 VH CDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Pro, Ser, or Val

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Asn, Thr, Trp, or Asp

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Gln, Arg, or Thr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Gln or His

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Gly or Gln

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Lys or Gly

<400>  72

Xaa Xaa Gly Xaa Xaa Xaa Xaa Gly Val Arg Gly Trp Asp Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox514 VL CDR3


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Ser or Met

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Leu, Tyr, or His

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Ser or Arg

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Gly, Ala, or no amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Trp or Phe

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Val, Gly, or Ala

<400>  73

Gln Ser Tyr Asp Ser Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  74
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 VH CDR2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Ile or Val

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Trp or Leu

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Asn or Gln

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Ser or Glu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Gly, Leu, or Pro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Ser, Tyr, or Asp

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Ile, Thr, or Arg

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Gly or Tyr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Tyr or Met

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is Ala or Asp

<400>  74

Gly Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 VH CDR3


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Asn or Ser

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Phe or Leu

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Ile or Val

<400>  75

Glu Gly Xaa Trp Asn Tyr Asp Ala Xaa Asp Xaa 
1               5                   10      


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 VL CDR1


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Ser or Asn

<400>  76

Thr Gly Thr Ser Xaa Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 VL CDR2


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Asn or Lys

<400>  77

Asp Val Ser Xaa Arg Pro Ser 
1               5           


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lox696 VL CDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ser, Leu, Met, or Ala

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Ser, Gly, or Gln

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Tyr, Arg, Ser, or Gly

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Thr or Met

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Ser, Trp, Gly, or Val

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Ser or Arg

<400>  78

Xaa Xaa Xaa Xaa Xaa Xaa Ser Thr Asn Trp Val 
1               5                   10      


