                         SEQUENCE LISTING

<110>  Memorial Sloane-Kettering Cancer Center
       University of Copenhagen
 
<120>  SMALL MOLECULES BLOCKING HISTONE READER DOMAINS

<130>  P4163PC00

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  4863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding fusion protein

<400>  1
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggc      720

gcgccaatga gcctggagcg cgagcttcgc cagctgagca aggcgaaagc caaggcgcag      780

agggccgggc agcggcgcga agaggccgcg ctgtgccacc agctggggga gctcctggcc      840

ggccatggcc gctacgccga ggctctggag cagcactggc aggagctgca gcttcgggag      900

cgcgctgacg accctctggg ctgtgccgtg gcccaccgca agatcggaga gcgcctggcc      960

gagatggagg actacccggc tgccttgcag caccagcacc agtacctgga gctggcacat     1020

tccctgcgca accacacgga gctgcagagg gcctgggcca ccatcggccg cacccacctg     1080

gacatctatg accactgcca gtcgagggat gctttgctgc aggcacaggc tgcctttgag     1140

aagagcttgg ctattgtgga tgaggagctg gaggggacac tggcccaggg agagctgaat     1200

gagatgagga cccgcctcta tctcaacctg ggcctcacct ttgagagcct gcagcagaca     1260

gccctgtgca acgattactt caggaagagc atcttccttg cggagcagaa ccacctttac     1320

gaggacctat tccgcgcccg ctacaacctg ggcaccatcc actggcgcgc gggccagcac     1380

tcccaggcta tgcgctgctt ggagggtgcc cgggagtgtg cgcacaccat gaggaagcgg     1440

ttcatggaga gcgagtgctg cgtggttatt gcacaggtcc tccaagacct gggagacttt     1500

ttggctgcca agcgagccct gaagaaggcc tacaggctgg gctcccagaa gcctgtgcag     1560

agggcagcca tctgtcagaa cctccagcat gtgctggcag tggtccggct gcagcaacag     1620

ctggaagagg ctgagggcag agaccctcag ggtgccatgg tcatctgtga gcagctaggg     1680

gacctcttct ccaaggcagg agactttccc agggcagctg aggcttacca gaagcagctg     1740

cgttttgctg agctgctgga cagaccgggt gctgagcggg ccatcatcca cgtgtccctg     1800

gccaccacac tgggagacat gaaggaccac catggggccg tgcgccacta tgaggaggaa     1860

ctgaggctgc gcagcggcaa cgtgctggag gaggccaaga cctggctgaa cattgcactg     1920

tcccgcgagg aggccggcga tgcctacgag ctgctggccc cgtgcttcca gaaagcgctc     1980

agctgtgccc agcaggccca gcgtccccag ctgcagaggc aggtcttgca gcatctccat     2040

accgtgcagc tgaggctgca gccccaggag gcccctgaga ccgaaaccag actgcgggag     2100

ctcagtgtag ctgaagatga agatgaggag gaggaggcgg aggaggcggc agccacagcg     2160

gagagcgaag ccctggaggc cggcgaggtg gagctctcag agggcgagga cgacaccgat     2220

ggcctgaccc cgcagctgga ggaggacgag gagcttcagg gccacctggg ccggcggaag     2280

gggagcaagt ggaaccggcg aaacgacatg ggggcgaccc tgctgcaccg agcctgcatc     2340

gagggccagc tgcgccgcgt ccaggacctt gtgaggcagg gccaccccct taaccctcgg     2400

gactactgtg gctggacacc tctgcacgag gcctgcaact acgggcatct agaaattgtc     2460

cgcttcctgc tggaccacgg ggccgcagtg gacgacccag gtggccaggg ctgcgaaggc     2520

atcacccccc tccacgatgc cctcaactgt ggccacttcg aggtggctga gctgctgctt     2580

gaacgggggg cgtccgtcac cctccgcact cgaaagggcc tcagcccgct ggagacgctg     2640

cagcagtggg tgaagctgta ccgcagggac ctggacctgg agacgcggca gaaggccagg     2700

gccatggaga tgctgctcca ggcggctgcc tcgggccaag atccccacag ctcccaggcc     2760

ttccacaccc caagcagcct tctgtttgac cccgagacct ctcctccttt gagcccctgc     2820

ccagaacccc cctctaatag cactagactc ccagaggcct ctcaggtcca tgtcagggtc     2880

tccccagggc aggcggcacc agccatggcc aggcctcgga ggagcaggca tgggccagcc     2940

agcagcagca gcagctcaga aggcgaggac agcgcaggcc ccgcacggcc gtcccagaag     3000

aggcctcggt gctcggccac agcacaacgg gtggcagcct ggacgcctgg ccccgccagc     3060

aacagggaag cagccacagc cagcaccagc cgggcagcct accaggcagc catccggggt     3120

gtgggcagtg ctcagagccg gctggggcct ggcccaccgc ggggccacag caaagccctt     3180

gccccccagg cagcgctcat cccggaggag gagtgcctgg ctggggactg gctggagctg     3240

gacatgcccc tgacccgcag ccgccggccc cgcccccggg gcactggaga caaccgcagg     3300

cccagtagta cctctgggtc ggacagtgag gagagcaggc cccgtgcccg agccaagcag     3360

gtccgcctga cctgcatgca gagttgcagt gcgccagtta acgcagggcc cagcagcctg     3420

gcttcagaac ctccagggag ccccagcacc cccagggtct cagagcccag tggggacagc     3480

tctgcggcag gccagccctt gggtccggcc ccgccccctc ccatccgggt tcgagttcaa     3540

gttcaggatc atctcttcct catccctgtc ccacacagca gtgacaccca ctctgtggcc     3600

tggctggccg agcaggcggc ccagcgctac taccagacct gcgggctgct gcccaggctc     3660

accctacgga aagagggggc cctgctggcc ccacaggacc tcatccctga tgtgctgcag     3720

agcaatgacg aggtgttggc tgaggtgact tcgtgggacc tgcccccgtt gactgaccgc     3780

taccgcaggg cctgccagag cctggggcaa ggggagcacc aacaggtgct gcaggccgtg     3840

gagctccagg gcttgggcct ctcgttcagc gcctgctccc tggccctgga ccaggcccag     3900

cttacacccc tgctgcgggc cctcaagctg cacacagcac tccgggagct gcgcctggca     3960

gggaaccggc tgggggacaa gtgtgtggct gagctggtgg ctgccctggg caccatgccc     4020

agcctggccc tccttgacct ctcctccaat cacctgggtc ccgaaggcct gcgccagctt     4080

gccatggggc tcccaggcca agccaccttg cagagtttgg aggaattaga tctatcgatg     4140

aaccccctgg gggacggctg tggccagtcc ctggcctccc tcctgcacgc ctgcccctta     4200

ctcagcaccc tgcgcctgca ggcgtgtggc ttcggcccca gcttctttct gagccaccag     4260

acagcactgg gtagtgcttt ccaagatgct gagcacctga agaccctgtc cctgtcctac     4320

aacgccctgg gagcccctgc cctggccagg accctgcaga gcctgcccgc cggcaccctc     4380

ctgcacttag agctcagctc cgtggcagcc ggcaagggtg attcggacct catggagcct     4440

gtattccgat acctggccaa ggaaggctgt gctctagccc acctgaccct gtctgcaaac     4500

cacctggggg acaaggctgt tagagacctg tgcagatgtc tctctctgtg cccctcactc     4560

atctcactgg atctgtctgc caaccctgag atcagctgtg ccagcttgga agagctcctg     4620

tccaccctcc aaaagcggcc ccaaggcctt agcttccttg gcctgtcagg ctgcgccgtc     4680

cagggtcccc tgggcctggg cctgtgggac aagatagccg cgcagctccg ggaactgcag     4740

ctgtgcagca gacgcctctg cgctgaggac agggacgccc tgcgccagct gcagcccagt     4800

cggccgggcc ccggcgagtg cacgctggac cacggctcca agctcttctt tcggcgcctc     4860

tag                                                                   4863


<210>  2
<211>  4137
<212>  DNA
<213>  Homo sapiens

<400>  2
atgagcctgg agcgcgagct tcgccagctg agcaaggcga aagccaaggc gcagagggcc       60

gggcagcggc gcgaagaggc cgcgctgtgc caccagctgg gggagctcct ggccggccat      120

ggccgctacg ccgaggctct ggagcagcac tggcaggagc tgcagcttcg ggagcgcgct      180

gacgaccctc tgggctgtgc cgtggcccac cgcaagatcg gagagcgcct ggccgagatg      240

gaggactacc cggctgcctt gcagcaccag caccagtacc tggagctggc acattccctg      300

cgcaaccaca cggagctgca gagggcctgg gccaccatcg gccgcaccca cctggacatc      360

tatgaccact gccagtcgag ggatgctttg ctgcaggcac aggctgcctt tgagaagagc      420

ttggctattg tggatgagga gctggagggg acactggccc agggagagct gaatgagatg      480

aggacccgcc tctatctcaa cctgggcctc acctttgaga gcctgcagca gacagccctg      540

tgcaacgatt acttcaggaa gagcatcttc cttgcggagc agaaccacct ttacgaggac      600

ctattccgcg cccgctacaa cctgggcacc atccactggc gcgcgggcca gcactcccag      660

gctatgcgct gcttggaggg tgcccgggag tgtgcgcaca ccatgaggaa gcggttcatg      720

gagagcgagt gctgcgtggt tattgcacag gtcctccaag acctgggaga ctttttggct      780

gccaagcgag ccctgaagaa ggcctacagg ctgggctccc agaagcctgt gcagagggca      840

gccatctgtc agaacctcca gcatgtgctg gcagtggtcc ggctgcagca acagctggaa      900

gaggctgagg gcagagaccc tcagggtgcc atggtcatct gtgagcagct aggggacctc      960

ttctccaagg caggagactt tcccagggca gctgaggctt accagaagca gctgcgtttt     1020

gctgagctgc tggacagacc gggtgctgag cgggccatca tccacgtgtc cctggccacc     1080

acactgggag acatgaagga ccaccatggg gccgtgcgcc actatgagga ggaactgagg     1140

ctgcgcagcg gcaacgtgct ggaggaggcc aagacctggc tgaacattgc actgtcccgc     1200

gaggaggccg gcgatgccta cgagctgctg gccccgtgct tccagaaagc gctcagctgt     1260

gcccagcagg cccagcgtcc ccagctgcag aggcaggtct tgcagcatct ccataccgtg     1320

cagctgaggc tgcagcccca ggaggcccct gagaccgaaa ccagactgcg ggagctcagt     1380

gtagctgaag atgaagatga ggaggaggag gcggaggagg cggcagccac agcggagagc     1440

gaagccctgg aggccggcga ggtggagctc tcagagggcg aggacgacac cgatggcctg     1500

accccgcagc tggaggagga cgaggagctt cagggccacc tgggccggcg gaaggggagc     1560

aagtggaacc ggcgaaacga catgggggcg accctgctgc accgagcctg catcgagggc     1620

cagctgcgcc gcgtccagga ccttgtgagg cagggccacc cccttaaccc tcgggactac     1680

tgtggctgga cacctctgca cgaggcctgc aactacgggc atctagaaat tgtccgcttc     1740

ctgctggacc acggggccgc agtggacgac ccaggtggcc agggctgcga aggcatcacc     1800

cccctccacg atgccctcaa ctgtggccac ttcgaggtgg ctgagctgct gcttgaacgg     1860

ggggcgtccg tcaccctccg cactcgaaag ggcctcagcc cgctggagac gctgcagcag     1920

tgggtgaagc tgtaccgcag ggacctggac ctggagacgc ggcagaaggc cagggccatg     1980

gagatgctgc tccaggcggc tgcctcgggc caagatcccc acagctccca ggccttccac     2040

accccaagca gccttctgtt tgaccccgag acctctcctc ctttgagccc ctgcccagaa     2100

cccccctcta atagcactag actcccagag gcctctcagg tccatgtcag ggtctcccca     2160

gggcaggcgg caccagccat ggccaggcct cggaggagca ggcatgggcc agccagcagc     2220

agcagcagct cagaaggcga ggacagcgca ggccccgcac ggccgtccca gaagaggcct     2280

cggtgctcgg ccacagcaca acgggtggca gcctggacgc ctggccccgc cagcaacagg     2340

gaagcagcca cagccagcac cagccgggca gcctaccagg cagccatccg gggtgtgggc     2400

agtgctcaga gccggctggg gcctggccca ccgcggggcc acagcaaagc ccttgccccc     2460

caggcagcgc tcatcccgga ggaggagtgc ctggctgggg actggctgga gctggacatg     2520

cccctgaccc gcagccgccg gccccgcccc cggggcactg gagacaaccg caggcccagt     2580

agtacctctg ggtcggacag tgaggagagc aggccccgtg cccgagccaa gcaggtccgc     2640

ctgacctgca tgcagagttg cagtgcgcca gttaacgcag ggcccagcag cctggcttca     2700

gaacctccag ggagccccag cacccccagg gtctcagagc ccagtgggga cagctctgcg     2760

gcaggccagc ccttgggtcc ggccccgccc cctcccatcc gggttcgagt tcaagttcag     2820

gatcatctct tcctcatccc tgtcccacac agcagtgaca cccactctgt ggcctggctg     2880

gccgagcagg cggcccagcg ctactaccag acctgcgggc tgctgcccag gctcacccta     2940

cggaaagagg gggccctgct ggccccacag gacctcatcc ctgatgtgct gcagagcaat     3000

gacgaggtgt tggctgaggt gacttcgtgg gacctgcccc cgttgactga ccgctaccgc     3060

agggcctgcc agagcctggg gcaaggggag caccaacagg tgctgcaggc cgtggagctc     3120

cagggcttgg gcctctcgtt cagcgcctgc tccctggccc tggaccaggc ccagcttaca     3180

cccctgctgc gggccctcaa gctgcacaca gcactccggg agctgcgcct ggcagggaac     3240

cggctggggg acaagtgtgt ggctgagctg gtggctgccc tgggcaccat gcccagcctg     3300

gccctccttg acctctcctc caatcacctg ggtcccgaag gcctgcgcca gcttgccatg     3360

gggctcccag gccaagccac cttgcagagt ttggaggaat tagatctatc gatgaacccc     3420

ctgggggacg gctgtggcca gtccctggcc tccctcctgc acgcctgccc cttactcagc     3480

accctgcgcc tgcaggcgtg tggcttcggc cccagcttct ttctgagcca ccagacagca     3540

ctgggtagtg ctttccaaga tgctgagcac ctgaagaccc tgtccctgtc ctacaacgcc     3600

ctgggagccc ctgccctggc caggaccctg cagagcctgc ccgccggcac cctcctgcac     3660

ttagagctca gctccgtggc agccggcaag ggtgattcgg acctcatgga gcctgtattc     3720

cgatacctgg ccaaggaagg ctgtgctcta gcccacctga ccctgtctgc aaaccacctg     3780

ggggacaagg ctgttagaga cctgtgcaga tgtctctctc tgtgcccctc actcatctca     3840

ctggatctgt ctgccaaccc tgagatcagc tgtgccagct tggaagagct cctgtccacc     3900

ctccaaaagc ggccccaagg ccttagcttc cttggcctgt caggctgcgc cgtccagggt     3960

cccctgggcc tgggcctgtg ggacaagata gccgcgcagc tccgggaact gcagctgtgc     4020

agcagacgcc tctgcgctga ggacagggac gccctgcgcc agctgcagcc cagtcggccg     4080

ggccccggcg agtgcacgct ggaccacggc tccaagctct tctttcggcg cctctag        4137


<210>  3
<211>  4137
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding mutant protein

<400>  3
atgagcctgg agcgcgagct tcgccagctg agcaaggcga aagccaaggc gcagagggcc       60

gggcagcggc gcgaagaggc cgcgctgtgc caccagctgg gggagctcct ggccggccat      120

ggccgctacg ccgaggctct ggagcagcac tggcaggagc tgcagcttcg ggagcgcgct      180

gacgaccctc tgggctgtgc cgtggcccac cgcaagatcg gagagcgcct ggccgagatg      240

gaggactacc cggctgcctt gcagcaccag caccagtacc tggagctggc acattccctg      300

cgcaaccaca cggagctgca gagggcctgg gccaccatcg gccgcaccca cctggacatc      360

tatgaccact gccagtcgag ggatgctttg ctgcaggcac aggctgcctt tgagaagagc      420

ttggctattg tggatgagga gctggagggg acactggccc agggagagct gaatgagatg      480

aggacccgcc tctatctcaa cctgggcctc acctttgaga gcctgcagca gacagccctg      540

tgcaacgatt acttcaggaa gagcatcttc cttgcggagc agaaccacct ttacgaggac      600

ctattccgcg cccgctacaa cctgggcacc atccactggc gcgcgggcca gcactcccag      660

gctatgcgct gcttggaggg tgcccgggag tgtgcgcaca ccatgaggaa gcggttcatg      720

gagagcgagt gctgcgtggt tattgcacag gtcctccaag acctgggaga ctttttggct      780

gccaagcgag ccctgaagaa ggcctacagg ctgggctccc agaagcctgt gcagagggca      840

gccatctgtc agaacctcca gcatgtgctg gcagtggtcc ggctgcagca acagctggaa      900

gaggctgagg gcagagaccc tcagggtgcc atggtcatct gtgagcagct aggggacctc      960

ttctccaagg caggagactt tcccagggca gctgaggctt accagaagca gctgcgtttt     1020

gctgagctgc tggacagacc gggtgctgag cgggccatca tccacgtgtc cctggccacc     1080

acactgggag acatgaagga ccaccatggg gccgtgcgcc actatgagga ggaactgagg     1140

ctgcgcagcg gcaacgtgct ggaggaggcc aagacctggc tgaacattgc actgtcccgc     1200

gaggaggccg gcgatgccta cgagctgctg gccccgtgct tccagaaagc gctcagctgt     1260

gcccagcagg cccagcgtcc ccagctgcag aggcaggtct tgcagcatct ccataccgtg     1320

cagctgaggc tgcagcccca ggaggcccct gagaccgaaa ccagactgcg ggagctcagt     1380

gtagctgaag atgaagatga ggaggaggag gcggaggagg cggcagccac agcggagagc     1440

gaagccctgg aggccggcga ggtggagctc tcagagggcg aggacgacac cgatggcctg     1500

accccgcagc tggaggagga cgaggagctt cagggccacc tgggccggcg gaaggggagc     1560

aagtggaacc ggcgaaacga catgggggcg accctgctgc accgagcctg catcgagggc     1620

cagctgcgcc gcgtccagga ccttgtgagg cagggccacc cccttaaccc tcgggactac     1680

tgtggctgga cacctctgca cgaggcctgc aactacgggc atctagaaat tgtccgcttc     1740

ctgctggacc acggggccgc agtggacgac ccaggtggcc agggctgcga aggcatcacc     1800

cccctccacg atgccctcaa ctgtggccac ttcgaggtgg ctgagctgct gcttgaacgg     1860

ggggcgtccg tcaccctccg cactcgaaag ggcctcagcc cgctggagac gctgcagcag     1920

tgggtgaagc tgtaccgcag ggacctggac ctggagacgc ggcagaaggc cagggccatg     1980

gagatgctgc tccaggcggc tgcctcgggc caagatcccc acagctccca ggccttccac     2040

accccaagca gccttctgtt tgaccccgag acctctcctc ctttgagccc ctgcccagaa     2100

cccccctcta atagcactag actcccagag gcctctcagg tccatgtcag ggtctcccca     2160

gggcaggcgg caccagccat ggccaggcct cggaggagca ggcatgggcc agccagcagc     2220

agcagcagct cagaaggcga ggacagcgca ggccccgcac ggccgtccca gaagaggcct     2280

cggtgctcgg ccacagcaca acgggtggca gcctggacgc ctggccccgc cagcaacagg     2340

gaagcagcca cagccagcac cagccgggca gcctaccagg cagccatccg gggtgtgggc     2400

agtgctcaga gccggctggg gcctggccca ccgcggggcc acagcaaagc ccttgccccc     2460

caggcagcgc tcatcccgga ggaggagtgc ctggctgggg actggctgga gctggacatg     2520

cccctgaccc gcagccgccg gccccgcccc cggggcactg gagacaaccg caggcccagt     2580

agtacctctg ggtcggacag tgaggagagc aggccccgtg cccgagccaa gcaggtccgc     2640

ctgacctgca tgcagagttg cagtgcgcca gttaacgcag ggcccagcag cctggcttca     2700

gaacctccag ggagccccag cacccccagg gtctcagagc ccagtgggga cagctctgcg     2760

gcaggccagc ccttgggtcc ggccccgccc cctcccatcc gggttcgagt tcaagttcag     2820

gatcatctct tcctcatccc tgtcccacac agcagtgaca cccactctgt ggcctggctg     2880

gccgagcagg cggcccagcg ctactaccag acctgcgggc tgctgcccag gctcacccta     2940

cggaaagagg gggccctgct ggccccacag gacctcatcc ctgatgtgct gcagagcaat     3000

gacgaggtgt tggctgaggt gacttcgtgg gacctgcccc cgttgactga ccgctaccgc     3060

agggcctgcc agagcctggg gcaaggggag caccaacagg tgctgcaggc cgtggagctc     3120

cagggcttgg gcctctcgtt cagcgcctgc tccctggccc tggaccaggc ccagcttaca     3180

cccctgctgc gggccctcaa gctgcacaca gcactccggg agctgcgcct ggcagggaac     3240

cggctggggg acaagtgtgt ggctgagctg gtggctgccc tgggcaccat gcccagcctg     3300

gccctccttg acctctcctc caatcacctg ggtcccgaag gcctgcgcca gcttgccatg     3360

gggctcccag gccaagccac cttgcagagt ttggaggaat tagatctatc gatgaacccc     3420

ctgggggacg gctgtggcca gtccctggcc tccctcctgc acgcctgccc cttactcagc     3480

accctgcgcc tgcaggcgtg tggcttcggc cccagcttct ttctgagcca ccagacagca     3540

ctgggtagtg ctttccaaga tgctgagcac ctgaagaccc tgtccctgtc ctacaacgcc     3600

ctgggagccc ctgccctggc caggaccctg cagagcctgc ccgccggcac cctcctgcac     3660

ttagagctca gctccgtggc agccggcaag ggtgattcgg acctcatgga gcctgtattc     3720

cgatacctgg ccaaggaagg ctgtgctcta gcccacctga ccctgtctgc aaaccacctg     3780

ggggacaagg ctgttagaga cctgtgcaga tgtctctctc tgtgcccctc actcatctca     3840

ctggatctgt ctgccaaccc tgagatcagc tgtgccagct tggaagagct cctgtccacc     3900

ctccaaaagc ggccccaagg ccttagcttc cttggcctgt caggctgcgc cgtccagggt     3960

cccctgggcc tgggcctgtg ggacaagata gccgcgcagc tccgggaact gcagctgtgc     4020

agcagacgcc tctgcgctga ggacagggac gccctgcgcc agctgcagcc cagtcggccg     4080

ggccccggcg agtgcacgct ggaccacggc tccaagctct tctttcggcg cctctag        4137


<210>  4
<211>  4863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding fusion protein

<400>  4
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggc      720

gcgccaatga gcctggagcg cgagcttcgc cagctgagca aggcgaaagc caaggcgcag      780

agggccgggc agcggcgcga agaggccgcg ctgtgccacc agctggggga gctcctggcc      840

ggccatggcc gctacgccga ggctctggag cagcactggc aggagctgca gcttcgggag      900

cgcgctgacg accctctggg ctgtgccgtg gcccaccgca agatcggaga gcgcctggcc      960

gagatggagg actacccggc tgccttgcag caccagcacc agtacctgga gctggcacat     1020

tccctgcgca accacacgga gctgcagagg gcctgggcca ccatcggccg cacccacctg     1080

gacatctatg accactgcca gtcgagggat gctttgctgc aggcacaggc tgcctttgag     1140

aagagcttgg ctattgtgga tgaggagctg gaggggacac tggcccaggg agagctgaat     1200

gagatgagga cccgcctcta tctcaacctg ggcctcacct ttgagagcct gcagcagaca     1260

gccctgtgca acgattactt caggaagagc atcttccttg cggagcagaa ccacctttac     1320

gaggacctat tccgcgcccg ctacaacctg ggcaccatcc actggcgcgc gggccagcac     1380

tcccaggcta tgcgctgctt ggagggtgcc cgggagtgtg cgcacaccat gaggaagcgg     1440

ttcatggaga gcgagtgctg cgtggttatt gcacaggtcc tccaagacct gggagacttt     1500

ttggctgcca agcgagccct gaagaaggcc tacaggctgg gctcccagaa gcctgtgcag     1560

agggcagcca tctgtcagaa cctccagcat gtgctggcag tggtccggct gcagcaacag     1620

ctggaagagg ctgagggcag agaccctcag ggtgccatgg tcatctgtga gcagctaggg     1680

gacctcttct ccaaggcagg agactttccc agggcagctg aggcttacca gaagcagctg     1740

cgttttgctg agctgctgga cagaccgggt gctgagcggg ccatcatcca cgtgtccctg     1800

gccaccacac tgggagacat gaaggaccac catggggccg tgcgccacta tgaggaggaa     1860

ctgaggctgc gcagcggcaa cgtgctggag gaggccaaga cctggctgaa cattgcactg     1920

tcccgcgagg aggccggcga tgcctacgag ctgctggccc cgtgcttcca gaaagcgctc     1980

agctgtgccc agcaggccca gcgtccccag ctgcagaggc aggtcttgca gcatctccat     2040

accgtgcagc tgaggctgca gccccaggag gcccctgaga ccgaaaccag actgcgggag     2100

ctcagtgtag ctgaagatga agatgaggag gaggaggcgg aggaggcggc agccacagcg     2160

gagagcgaag ccctggaggc cggcgaggtg gagctctcag agggcgagga cgacaccgat     2220

ggcctgaccc cgcagctgga ggaggacgag gagcttcagg gccacctggg ccggcggaag     2280

gggagcaagt ggaaccggcg aaacgacatg ggggcgaccc tgctgcaccg agcctgcatc     2340

gagggccagc tgcgccgcgt ccaggacctt gtgaggcagg gccaccccct taaccctcgg     2400

gactactgtg gctggacacc tctgcacgag gcctgcaact acgggcatct agaaattgtc     2460

cgcttcctgc tggaccacgg ggccgcagtg gacgacccag gtggccaggg ctgcgaaggc     2520

atcacccccc tccacgatgc cctcaactgt ggccacttcg aggtggctga gctgctgctt     2580

gaacgggggg cgtccgtcac cctccgcact cgaaagggcc tcagcccgct ggagacgctg     2640

cagcagtggg tgaagctgta ccgcagggac ctggacctgg agacgcggca gaaggccagg     2700

gccatggaga tgctgctcca ggcggctgcc tcgggccaag atccccacag ctcccaggcc     2760

ttccacaccc caagcagcct tctgtttgac cccgagacct ctcctccttt gagcccctgc     2820

ccagaacccc cctctaatag cactagactc ccagaggcct ctcaggtcca tgtcagggtc     2880

tccccagggc aggcggcacc agccatggcc aggcctcgga ggagcaggca tgggccagcc     2940

agcagcagca gcagctcaga aggcgaggac agcgcaggcc ccgcacggcc gtcccagaag     3000

aggcctcggt gctcggccac agcacaacgg gtggcagcct ggacgcctgg ccccgccagc     3060

aacagggaag cagccacagc cagcaccagc cgggcagcct accaggcagc catccggggt     3120

gtgggcagtg ctcagagccg gctggggcct ggcccaccgc ggggccacag caaagccctt     3180

gccccccagg cagcgctcat cccggaggag gagtgcctgg ctggggactg gctggagctg     3240

gacatgcccc tgacccgcag ccgccggccc cgcccccggg gcactggaga caaccgcagg     3300

cccagtagta cctctgggtc ggacagtgag gagagcaggc cccgtgcccg agccaagcag     3360

gtccgcctga cctgcatgca gagttgcagt gcgccagtta acgcagggcc cagcagcctg     3420

gcttcagaac ctccagggag ccccagcacc cccagggtct cagagcccag tggggacagc     3480

tctgcggcag gccagccctt gggtccggcc ccgccccctc ccatccgggt tcgagttcaa     3540

gttcaggatc atctcttcct catccctgtc ccacacagca gtgacaccca ctctgtggcc     3600

tggctggccg agcaggcggc ccagcgctac taccagacct gcgggctgct gcccaggctc     3660

accctacgga aagagggggc cctgctggcc ccacaggacc tcatccctga tgtgctgcag     3720

agcaatgacg aggtgttggc tgaggtgact tcgtgggacc tgcccccgtt gactgaccgc     3780

taccgcaggg cctgccagag cctggggcaa ggggagcacc aacaggtgct gcaggccgtg     3840

gagctccagg gcttgggcct ctcgttcagc gcctgctccc tggccctgga ccaggcccag     3900

cttacacccc tgctgcgggc cctcaagctg cacacagcac tccgggagct gcgcctggca     3960

gggaaccggc tgggggacaa gtgtgtggct gagctggtgg ctgccctggg caccatgccc     4020

agcctggccc tccttgacct ctcctccaat cacctgggtc ccgaaggcct gcgccagctt     4080

gccatggggc tcccaggcca agccaccttg cagagtttgg aggaattaga tctatcgatg     4140

aaccccctgg gggacggctg tggccagtcc ctggcctccc tcctgcacgc ctgcccctta     4200

ctcagcaccc tgcgcctgca ggcgtgtggc ttcggcccca gcttctttct gagccaccag     4260

acagcactgg gtagtgcttt ccaagatgct gagcacctga agaccctgtc cctgtcctac     4320

aacgccctgg gagcccctgc cctggccagg accctgcaga gcctgcccgc cggcaccctc     4380

ctgcacttag agctcagctc cgtggcagcc ggcaagggtg attcggacct catggagcct     4440

gtattccgat acctggccaa ggaaggctgt gctctagccc acctgaccct gtctgcaaac     4500

cacctggggg acaaggctgt tagagacctg tgcagatgtc tctctctgtg cccctcactc     4560

atctcactgg atctgtctgc caaccctgag atcagctgtg ccagcttgga agagctcctg     4620

tccaccctcc aaaagcggcc ccaaggcctt agcttccttg gcctgtcagg ctgcgccgtc     4680

cagggtcccc tgggcctggg cctgtgggac aagatagccg cgcagctccg ggaactgcag     4740

ctgtgcagca gacgcctctg cgctgaggac agggacgccc tgcgccagct gcagcccagt     4800

cggccgggcc ccggcgagtg cacgctggac cacggctcca agctcttctt tcggcgcctc     4860

tag                                                                   4863


<210>  5
<211>  4137
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding mutant protein

<400>  5
atgagcctgg agcgcgagct tcgccagctg agcaaggcga aagccaaggc gcagagggcc       60

gggcagcggc gcgaagaggc cgcgctgtgc caccagctgg gggagctcct ggccggccat      120

ggccgctacg ccgaggctct ggagcagcac tggcaggagc tgcagcttcg ggagcgcgct      180

gacgaccctc tgggctgtgc cgtggcccac cgcaagatcg gagagcgcct ggccgagatg      240

gaggactacc cggctgcctt gcagcaccag caccagtacc tggagctggc acattccctg      300

cgcaaccaca cggagctgca gagggcctgg gccaccatcg gccgcaccca cctggacatc      360

tatgaccact gccagtcgag ggatgctttg ctgcaggcac aggctgcctt tgagaagagc      420

ttggctattg tggatgagga gctggagggg acactggccc agggagagct gaatgagatg      480

aggacccgcc tctatctcaa cctgggcctc acctttgaga gcctgcagca gacagccctg      540

tgcaacgatt acttcaggaa gagcatcttc cttgcggagc agaaccacct ttacgaggac      600

ctattccgcg cccgctacaa cctgggcacc atccactggc gcgcgggcca gcactcccag      660

gctatgcgct gcttggaggg tgcccgggag tgtgcgcaca ccatgaggaa gcggttcatg      720

gagagcgagt gctgcgtggt tattgcacag gtcctccaag acctgggaga ctttttggct      780

gccaagcgag ccctgaagaa ggcctacagg ctgggctccc agaagcctgt gcagagggca      840

gccatctgtc agaacctcca gcatgtgctg gcagtggtcc ggctgcagca acagctggaa      900

gaggctgagg gcagagaccc tcagggtgcc atggtcatct gtgagcagct aggggacctc      960

ttctccaagg caggagactt tcccagggca gctgaggctt accagaagca gctgcgtttt     1020

gctgagctgc tggacagacc gggtgctgag cgggccatca tccacgtgtc cctggccacc     1080

acactgggag acatgaagga ccaccatggg gccgtgcgcc actatgagga ggaactgagg     1140

ctgcgcagcg gcaacgtgct ggaggaggcc aagacctggc tgaacattgc actgtcccgc     1200

gaggaggccg gcgatgccta cgagctgctg gccccgtgct tccagaaagc gctcagctgt     1260

gcccagcagg cccagcgtcc ccagctgcag aggcaggtct tgcagcatct ccataccgtg     1320

cagctgaggc tgcagcccca ggaggcccct gagaccgaaa ccagactgcg ggagctcagt     1380

gtagctgaag atgaagatga ggaggaggag gcggaggagg cggcagccac agcggagagc     1440

gaagccctgg aggccggcga ggtggagctc tcagagggcg aggacgacac cgatggcctg     1500

accccgcagc tggaggagga cgaggagctt cagggccacc tgggccggcg gaaggggagc     1560

aagtggaacc ggcgaaacga catgggggag accctgctgc accgagcctg catcgagggc     1620

cagctgcgcc gcgtccagga ccttgtgagg cagggccacc cccttaaccc tcgggcctac     1680

tgtggctgga cacctctgca cgaggcctgc aactacgggc atctagaaat tgtccgcttc     1740

ctgctggacc acggggccgc agtggacgac ccaggtggcc agggctgcga aggcatcacc     1800

cccctccacg atgccctcaa ctgtggccac ttcgaggtgg ctgagctgct gcttgaacgg     1860

ggggcgtccg tcaccctccg cactcgaaag ggcctcagcc cgctggagac gctgcagcag     1920

tgggtgaagc tgtaccgcag ggacctggac ctggagacgc ggcagaaggc cagggccatg     1980

gagatgctgc tccaggcggc tgcctcgggc caagatcccc acagctccca ggccttccac     2040

accccaagca gccttctgtt tgaccccgag acctctcctc ctttgagccc ctgcccagaa     2100

cccccctcta atagcactag actcccagag gcctctcagg tccatgtcag ggtctcccca     2160

gggcaggcgg caccagccat ggccaggcct cggaggagca ggcatgggcc agccagcagc     2220

agcagcagct cagaaggcga ggacagcgca ggccccgcac ggccgtccca gaagaggcct     2280

cggtgctcgg ccacagcaca acgggtggca gcctggacgc ctggccccgc cagcaacagg     2340

gaagcagcca cagccagcac cagccgggca gcctaccagg cagccatccg gggtgtgggc     2400

agtgctcaga gccggctggg gcctggccca ccgcggggcc acagcaaagc ccttgccccc     2460

caggcagcgc tcatcccgga ggaggagtgc ctggctgggg actggctgga gctggacatg     2520

cccctgaccc gcagccgccg gccccgcccc cggggcactg gagacaaccg caggcccagt     2580

agtacctctg ggtcggacag tgaggagagc aggccccgtg cccgagccaa gcaggtccgc     2640

ctgacctgca tgcagagttg cagtgcgcca gttaacgcag ggcccagcag cctggcttca     2700

gaacctccag ggagccccag cacccccagg gtctcagagc ccagtgggga cagctctgcg     2760

gcaggccagc ccttgggtcc ggccccgccc cctcccatcc gggttcgagt tcaagttcag     2820

gatcatctct tcctcatccc tgtcccacac agcagtgaca cccactctgt ggcctggctg     2880

gccgagcagg cggcccagcg ctactaccag acctgcgggc tgctgcccag gctcacccta     2940

cggaaagagg gggccctgct ggccccacag gacctcatcc ctgatgtgct gcagagcaat     3000

gacgaggtgt tggctgaggt gacttcgtgg gacctgcccc cgttgactga ccgctaccgc     3060

agggcctgcc agagcctggg gcaaggggag caccaacagg tgctgcaggc cgtggagctc     3120

cagggcttgg gcctctcgtt cagcgcctgc tccctggccc tggaccaggc ccagcttaca     3180

cccctgctgc gggccctcaa gctgcacaca gcactccggg agctgcgcct ggcagggaac     3240

cggctggggg acaagtgtgt ggctgagctg gtggctgccc tgggcaccat gcccagcctg     3300

gccctccttg acctctcctc caatcacctg ggtcccgaag gcctgcgcca gcttgccatg     3360

gggctcccag gccaagccac cttgcagagt ttggaggaat tagatctatc gatgaacccc     3420

ctgggggacg gctgtggcca gtccctggcc tccctcctgc acgcctgccc cttactcagc     3480

accctgcgcc tgcaggcgtg tggcttcggc cccagcttct ttctgagcca ccagacagca     3540

ctgggtagtg ctttccaaga tgctgagcac ctgaagaccc tgtccctgtc ctacaacgcc     3600

ctgggagccc ctgccctggc caggaccctg cagagcctgc ccgccggcac cctcctgcac     3660

ttagagctca gctccgtggc agccggcaag ggtgattcgg acctcatgga gcctgtattc     3720

cgatacctgg ccaaggaagg ctgtgctcta gcccacctga ccctgtctgc aaaccacctg     3780

ggggacaagg ctgttagaga cctgtgcaga tgtctctctc tgtgcccctc actcatctca     3840

ctggatctgt ctgccaaccc tgagatcagc tgtgccagct tggaagagct cctgtccacc     3900

ctccaaaagc ggccccaagg ccttagcttc cttggcctgt caggctgcgc cgtccagggt     3960

cccctgggcc tgggcctgtg ggacaagata gccgcgcagc tccgggaact gcagctgtgc     4020

agcagacgcc tctgcgctga ggacagggac gccctgcgcc agctgcagcc cagtcggccg     4080

ggccccggcg agtgcacgct ggaccacggc tccaagctct tctttcggcg cctctag        4137


<210>  6
<211>  4863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding fusion protein

<400>  6
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggc      720

gcgccaatga gcctggagcg cgagcttcgc cagctgagca aggcgaaagc caaggcgcag      780

agggccgggc agcggcgcga agaggccgcg ctgtgccacc agctggggga gctcctggcc      840

ggccatggcc gctacgccga ggctctggag cagcactggc aggagctgca gcttcgggag      900

cgcgctgacg accctctggg ctgtgccgtg gcccaccgca agatcggaga gcgcctggcc      960

gagatggagg actacccggc tgccttgcag caccagcacc agtacctgga gctggcacat     1020

tccctgcgca accacacgga gctgcagagg gcctgggcca ccatcggccg cacccacctg     1080

gacatctatg accactgcca gtcgagggat gctttgctgc aggcacaggc tgcctttgag     1140

aagagcttgg ctattgtgga tgaggagctg gaggggacac tggcccaggg agagctgaat     1200

gagatgagga cccgcctcta tctcaacctg ggcctcacct ttgagagcct gcagcagaca     1260

gccctgtgca acgattactt caggaagagc atcttccttg cggagcagaa ccacctttac     1320

gaggacctat tccgcgcccg ctacaacctg ggcaccatcc actggcgcgc gggccagcac     1380

tcccaggcta tgcgctgctt ggagggtgcc cgggagtgtg cgcacaccat gaggaagcgg     1440

ttcatggaga gcgagtgctg cgtggttatt gcacaggtcc tccaagacct gggagacttt     1500

ttggctgcca agcgagccct gaagaaggcc tacaggctgg gctcccagaa gcctgtgcag     1560

agggcagcca tctgtcagaa cctccagcat gtgctggcag tggtccggct gcagcaacag     1620

ctggaagagg ctgagggcag agaccctcag ggtgccatgg tcatctgtga gcagctaggg     1680

gacctcttct ccaaggcagg agactttccc agggcagctg aggcttacca gaagcagctg     1740

cgttttgctg agctgctgga cagaccgggt gctgagcggg ccatcatcca cgtgtccctg     1800

gccaccacac tgggagacat gaaggaccac catggggccg tgcgccacta tgaggaggaa     1860

ctgaggctgc gcagcggcaa cgtgctggag gaggccaaga cctggctgaa cattgcactg     1920

tcccgcgagg aggccggcga tgcctacgag ctgctggccc cgtgcttcca gaaagcgctc     1980

agctgtgccc agcaggccca gcgtccccag ctgcagaggc aggtcttgca gcatctccat     2040

accgtgcagc tgaggctgca gccccaggag gcccctgaga ccgaaaccag actgcgggag     2100

ctcagtgtag ctgaagatga agatgaggag gaggaggcgg aggaggcggc agccacagcg     2160

gagagcgaag ccctggaggc cggcgaggtg gagctctcag agggcgagga cgacaccgat     2220

ggcctgaccc cgcagctgga ggaggacgag gagcttcagg gccacctggg ccggcggaag     2280

gggagcaagt ggaaccggcg aaacgacatg ggggagaccc tgctgcaccg agcctgcatc     2340

gagggccagc tgcgccgcgt ccaggacctt gtgaggcagg gccaccccct taaccctcgg     2400

gcctactgtg gctggacacc tctgcacgag gcctgcaact acgggcatct agaaattgtc     2460

cgcttcctgc tggaccacgg ggccgcagtg gacgacccag gtggccaggg ctgcgaaggc     2520

atcacccccc tccacgatgc cctcaactgt ggccacttcg aggtggctga gctgctgctt     2580

gaacgggggg cgtccgtcac cctccgcact cgaaagggcc tcagcccgct ggagacgctg     2640

cagcagtggg tgaagctgta ccgcagggac ctggacctgg agacgcggca gaaggccagg     2700

gccatggaga tgctgctcca ggcggctgcc tcgggccaag atccccacag ctcccaggcc     2760

ttccacaccc caagcagcct tctgtttgac cccgagacct ctcctccttt gagcccctgc     2820

ccagaacccc cctctaatag cactagactc ccagaggcct ctcaggtcca tgtcagggtc     2880

tccccagggc aggcggcacc agccatggcc aggcctcgga ggagcaggca tgggccagcc     2940

agcagcagca gcagctcaga aggcgaggac agcgcaggcc ccgcacggcc gtcccagaag     3000

aggcctcggt gctcggccac agcacaacgg gtggcagcct ggacgcctgg ccccgccagc     3060

aacagggaag cagccacagc cagcaccagc cgggcagcct accaggcagc catccggggt     3120

gtgggcagtg ctcagagccg gctggggcct ggcccaccgc ggggccacag caaagccctt     3180

gccccccagg cagcgctcat cccggaggag gagtgcctgg ctggggactg gctggagctg     3240

gacatgcccc tgacccgcag ccgccggccc cgcccccggg gcactggaga caaccgcagg     3300

cccagtagta cctctgggtc ggacagtgag gagagcaggc cccgtgcccg agccaagcag     3360

gtccgcctga cctgcatgca gagttgcagt gcgccagtta acgcagggcc cagcagcctg     3420

gcttcagaac ctccagggag ccccagcacc cccagggtct cagagcccag tggggacagc     3480

tctgcggcag gccagccctt gggtccggcc ccgccccctc ccatccgggt tcgagttcaa     3540

gttcaggatc atctcttcct catccctgtc ccacacagca gtgacaccca ctctgtggcc     3600

tggctggccg agcaggcggc ccagcgctac taccagacct gcgggctgct gcccaggctc     3660

accctacgga aagagggggc cctgctggcc ccacaggacc tcatccctga tgtgctgcag     3720

agcaatgacg aggtgttggc tgaggtgact tcgtgggacc tgcccccgtt gactgaccgc     3780

taccgcaggg cctgccagag cctggggcaa ggggagcacc aacaggtgct gcaggccgtg     3840

gagctccagg gcttgggcct ctcgttcagc gcctgctccc tggccctgga ccaggcccag     3900

cttacacccc tgctgcgggc cctcaagctg cacacagcac tccgggagct gcgcctggca     3960

gggaaccggc tgggggacaa gtgtgtggct gagctggtgg ctgccctggg caccatgccc     4020

agcctggccc tccttgacct ctcctccaat cacctgggtc ccgaaggcct gcgccagctt     4080

gccatggggc tcccaggcca agccaccttg cagagtttgg aggaattaga tctatcgatg     4140

aaccccctgg gggacggctg tggccagtcc ctggcctccc tcctgcacgc ctgcccctta     4200

ctcagcaccc tgcgcctgca ggcgtgtggc ttcggcccca gcttctttct gagccaccag     4260

acagcactgg gtagtgcttt ccaagatgct gagcacctga agaccctgtc cctgtcctac     4320

aacgccctgg gagcccctgc cctggccagg accctgcaga gcctgcccgc cggcaccctc     4380

ctgcacttag agctcagctc cgtggcagcc ggcaagggtg attcggacct catggagcct     4440

gtattccgat acctggccaa ggaaggctgt gctctagccc acctgaccct gtctgcaaac     4500

cacctggggg acaaggctgt tagagacctg tgcagatgtc tctctctgtg cccctcactc     4560

atctcactgg atctgtctgc caaccctgag atcagctgtg ccagcttgga agagctcctg     4620

tccaccctcc aaaagcggcc ccaaggcctt agcttccttg gcctgtcagg ctgcgccgtc     4680

cagggtcccc tgggcctggg cctgtgggac aagatagccg cgcagctccg ggaactgcag     4740

ctgtgcagca gacgcctctg cgctgaggac agggacgccc tgcgccagct gcagcccagt     4800

cggccgggcc ccggcgagtg cacgctggac cacggctcca agctcttctt tcggcgcctc     4860

tag                                                                   4863


<210>  7
<211>  4137
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding mutant protein

<400>  7
atgagcctgg agcgcgagct tcgccagctg agcaaggcga aagccaaggc gcagagggcc       60

gggcagcggc gcgaagaggc cgcgctgtgc caccagctgg gggagctcct ggccggccat      120

ggccgctacg ccgaggctct ggagcagcac tggcaggagc tgcagcttcg ggagcgcgct      180

gacgaccctc tgggctgtgc cgtggcccac cgcaagatcg gagagcgcct ggccgagatg      240

gaggactacc cggctgcctt gcagcaccag caccagtacc tggagctggc acattccctg      300

cgcaaccaca cggagctgca gagggcctgg gccaccatcg gccgcaccca cctggacatc      360

tatgaccact gccagtcgag ggatgctttg ctgcaggcac aggctgcctt tgagaagagc      420

ttggctattg tggatgagga gctggagggg acactggccc agggagagct gaatgagatg      480

aggacccgcc tctatctcaa cctgggcctc acctttgaga gcctgcagca gacagccctg      540

tgcaacgatt acttcaggaa gagcatcttc cttgcggagc agaaccacct ttacgaggac      600

ctattccgcg cccgctacaa cctgggcacc atccactggc gcgcgggcca gcactcccag      660

gctatgcgct gcttggaggg tgcccgggag tgtgcgcaca ccatgaggaa gcggttcatg      720

gagagcgagt gctgcgtggt tattgcacag gtcctccaag acctgggaga ctttttggct      780

gccaagcgag ccctgaagaa ggcctacagg ctgggctccc agaagcctgt gcagagggca      840

gccatctgtc agaacctcca gcatgtgctg gcagtggtcc ggctgcagca acagctggaa      900

gaggctgagg gcagagaccc tcagggtgcc atggtcatct gtgagcagct aggggacctc      960

ttctccaagg caggagactt tcccagggca gctgaggctt accagaagca gctgcgtttt     1020

gctgagctgc tggacagacc gggtgctgag cgggccatca tccacgtgtc cctggccacc     1080

acactgggag acatgaagga ccaccatggg gccgtgcgcc actatgagga ggaactgagg     1140

ctgcgcagcg gcaacgtgct ggaggaggcc aagacctggc tgaacattgc actgtcccgc     1200

gaggaggccg gcgatgccta cgagctgctg gccccgtgct tccagaaagc gctcagctgt     1260

gcccagcagg cccagcgtcc ccagctgcag aggcaggtct tgcagcatct ccataccgtg     1320

cagctgaggc tgcagcccca ggaggcccct gagaccgaaa ccagactgcg ggagctcagt     1380

gtagctgaag atgaagatga ggaggaggag gcggaggagg cggcagccac agcggagagc     1440

gaagccctgg aggccggcga ggtggagctc tcagagggcg aggacgacac cgatggcctg     1500

accccgcagc tggaggagga cgaggagctt cagggccacc tgggccggcg gaaggggagc     1560

aagtggaacc ggcgaaacga catgggggag accctgctgc accgagcctg catcgagggc     1620

cagctgcgcc gcgtccagga ccttgtgagg cagggccacc cccttaaccc tcgggactac     1680

tgtggcgcga cacctctgca cgaggcctgc aactacgggc atctagaaat tgtccgcttc     1740

ctgctggacc acggggccgc agtggacgac ccaggtggcc agggctgcga aggcatcacc     1800

cccctccacg atgccctcaa ctgtggccac ttcgaggtgg ctgagctgct gcttgaacgg     1860

ggggcgtccg tcaccctccg cactcgaaag ggcctcagcc cgctggagac gctgcagcag     1920

tgggtgaagc tgtaccgcag ggacctggac ctggagacgc ggcagaaggc cagggccatg     1980

gagatgctgc tccaggcggc tgcctcgggc caagatcccc acagctccca ggccttccac     2040

accccaagca gccttctgtt tgaccccgag acctctcctc ctttgagccc ctgcccagaa     2100

cccccctcta atagcactag actcccagag gcctctcagg tccatgtcag ggtctcccca     2160

gggcaggcgg caccagccat ggccaggcct cggaggagca ggcatgggcc agccagcagc     2220

agcagcagct cagaaggcga ggacagcgca ggccccgcac ggccgtccca gaagaggcct     2280

cggtgctcgg ccacagcaca acgggtggca gcctggacgc ctggccccgc cagcaacagg     2340

gaagcagcca cagccagcac cagccgggca gcctaccagg cagccatccg gggtgtgggc     2400

agtgctcaga gccggctggg gcctggccca ccgcggggcc acagcaaagc ccttgccccc     2460

caggcagcgc tcatcccgga ggaggagtgc ctggctgggg actggctgga gctggacatg     2520

cccctgaccc gcagccgccg gccccgcccc cggggcactg gagacaaccg caggcccagt     2580

agtacctctg ggtcggacag tgaggagagc aggccccgtg cccgagccaa gcaggtccgc     2640

ctgacctgca tgcagagttg cagtgcgcca gttaacgcag ggcccagcag cctggcttca     2700

gaacctccag ggagccccag cacccccagg gtctcagagc ccagtgggga cagctctgcg     2760

gcaggccagc ccttgggtcc ggccccgccc cctcccatcc gggttcgagt tcaagttcag     2820

gatcatctct tcctcatccc tgtcccacac agcagtgaca cccactctgt ggcctggctg     2880

gccgagcagg cggcccagcg ctactaccag acctgcgggc tgctgcccag gctcacccta     2940

cggaaagagg gggccctgct ggccccacag gacctcatcc ctgatgtgct gcagagcaat     3000

gacgaggtgt tggctgaggt gacttcgtgg gacctgcccc cgttgactga ccgctaccgc     3060

agggcctgcc agagcctggg gcaaggggag caccaacagg tgctgcaggc cgtggagctc     3120

cagggcttgg gcctctcgtt cagcgcctgc tccctggccc tggaccaggc ccagcttaca     3180

cccctgctgc gggccctcaa gctgcacaca gcactccggg agctgcgcct ggcagggaac     3240

cggctggggg acaagtgtgt ggctgagctg gtggctgccc tgggcaccat gcccagcctg     3300

gccctccttg acctctcctc caatcacctg ggtcccgaag gcctgcgcca gcttgccatg     3360

gggctcccag gccaagccac cttgcagagt ttggaggaat tagatctatc gatgaacccc     3420

ctgggggacg gctgtggcca gtccctggcc tccctcctgc acgcctgccc cttactcagc     3480

accctgcgcc tgcaggcgtg tggcttcggc cccagcttct ttctgagcca ccagacagca     3540

ctgggtagtg ctttccaaga tgctgagcac ctgaagaccc tgtccctgtc ctacaacgcc     3600

ctgggagccc ctgccctggc caggaccctg cagagcctgc ccgccggcac cctcctgcac     3660

ttagagctca gctccgtggc agccggcaag ggtgattcgg acctcatgga gcctgtattc     3720

cgatacctgg ccaaggaagg ctgtgctcta gcccacctga ccctgtctgc aaaccacctg     3780

ggggacaagg ctgttagaga cctgtgcaga tgtctctctc tgtgcccctc actcatctca     3840

ctggatctgt ctgccaaccc tgagatcagc tgtgccagct tggaagagct cctgtccacc     3900

ctccaaaagc ggccccaagg ccttagcttc cttggcctgt caggctgcgc cgtccagggt     3960

cccctgggcc tgggcctgtg ggacaagata gccgcgcagc tccgggaact gcagctgtgc     4020

agcagacgcc tctgcgctga ggacagggac gccctgcgcc agctgcagcc cagtcggccg     4080

ggccccggcg agtgcacgct ggaccacggc tccaagctct tctttcggcg cctctag        4137


<210>  8
<211>  4863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding fusion protein

<400>  8
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggc      720

gcgccaatga gcctggagcg cgagcttcgc cagctgagca aggcgaaagc caaggcgcag      780

agggccgggc agcggcgcga agaggccgcg ctgtgccacc agctggggga gctcctggcc      840

ggccatggcc gctacgccga ggctctggag cagcactggc aggagctgca gcttcgggag      900

cgcgctgacg accctctggg ctgtgccgtg gcccaccgca agatcggaga gcgcctggcc      960

gagatggagg actacccggc tgccttgcag caccagcacc agtacctgga gctggcacat     1020

tccctgcgca accacacgga gctgcagagg gcctgggcca ccatcggccg cacccacctg     1080

gacatctatg accactgcca gtcgagggat gctttgctgc aggcacaggc tgcctttgag     1140

aagagcttgg ctattgtgga tgaggagctg gaggggacac tggcccaggg agagctgaat     1200

gagatgagga cccgcctcta tctcaacctg ggcctcacct ttgagagcct gcagcagaca     1260

gccctgtgca acgattactt caggaagagc atcttccttg cggagcagaa ccacctttac     1320

gaggacctat tccgcgcccg ctacaacctg ggcaccatcc actggcgcgc gggccagcac     1380

tcccaggcta tgcgctgctt ggagggtgcc cgggagtgtg cgcacaccat gaggaagcgg     1440

ttcatggaga gcgagtgctg cgtggttatt gcacaggtcc tccaagacct gggagacttt     1500

ttggctgcca agcgagccct gaagaaggcc tacaggctgg gctcccagaa gcctgtgcag     1560

agggcagcca tctgtcagaa cctccagcat gtgctggcag tggtccggct gcagcaacag     1620

ctggaagagg ctgagggcag agaccctcag ggtgccatgg tcatctgtga gcagctaggg     1680

gacctcttct ccaaggcagg agactttccc agggcagctg aggcttacca gaagcagctg     1740

cgttttgctg agctgctgga cagaccgggt gctgagcggg ccatcatcca cgtgtccctg     1800

gccaccacac tgggagacat gaaggaccac catggggccg tgcgccacta tgaggaggaa     1860

ctgaggctgc gcagcggcaa cgtgctggag gaggccaaga cctggctgaa cattgcactg     1920

tcccgcgagg aggccggcga tgcctacgag ctgctggccc cgtgcttcca gaaagcgctc     1980

agctgtgccc agcaggccca gcgtccccag ctgcagaggc aggtcttgca gcatctccat     2040

accgtgcagc tgaggctgca gccccaggag gcccctgaga ccgaaaccag actgcgggag     2100

ctcagtgtag ctgaagatga agatgaggag gaggaggcgg aggaggcggc agccacagcg     2160

gagagcgaag ccctggaggc cggcgaggtg gagctctcag agggcgagga cgacaccgat     2220

ggcctgaccc cgcagctgga ggaggacgag gagcttcagg gccacctggg ccggcggaag     2280

gggagcaagt ggaaccggcg aaacgacatg ggggagaccc tgctgcaccg agcctgcatc     2340

gagggccagc tgcgccgcgt ccaggacctt gtgaggcagg gccaccccct taaccctcgg     2400

gactactgtg gcgcgacacc tctgcacgag gcctgcaact acgggcatct agaaattgtc     2460

cgcttcctgc tggaccacgg ggccgcagtg gacgacccag gtggccaggg ctgcgaaggc     2520

atcacccccc tccacgatgc cctcaactgt ggccacttcg aggtggctga gctgctgctt     2580

gaacgggggg cgtccgtcac cctccgcact cgaaagggcc tcagcccgct ggagacgctg     2640

cagcagtggg tgaagctgta ccgcagggac ctggacctgg agacgcggca gaaggccagg     2700

gccatggaga tgctgctcca ggcggctgcc tcgggccaag atccccacag ctcccaggcc     2760

ttccacaccc caagcagcct tctgtttgac cccgagacct ctcctccttt gagcccctgc     2820

ccagaacccc cctctaatag cactagactc ccagaggcct ctcaggtcca tgtcagggtc     2880

tccccagggc aggcggcacc agccatggcc aggcctcgga ggagcaggca tgggccagcc     2940

agcagcagca gcagctcaga aggcgaggac agcgcaggcc ccgcacggcc gtcccagaag     3000

aggcctcggt gctcggccac agcacaacgg gtggcagcct ggacgcctgg ccccgccagc     3060

aacagggaag cagccacagc cagcaccagc cgggcagcct accaggcagc catccggggt     3120

gtgggcagtg ctcagagccg gctggggcct ggcccaccgc ggggccacag caaagccctt     3180

gccccccagg cagcgctcat cccggaggag gagtgcctgg ctggggactg gctggagctg     3240

gacatgcccc tgacccgcag ccgccggccc cgcccccggg gcactggaga caaccgcagg     3300

cccagtagta cctctgggtc ggacagtgag gagagcaggc cccgtgcccg agccaagcag     3360

gtccgcctga cctgcatgca gagttgcagt gcgccagtta acgcagggcc cagcagcctg     3420

gcttcagaac ctccagggag ccccagcacc cccagggtct cagagcccag tggggacagc     3480

tctgcggcag gccagccctt gggtccggcc ccgccccctc ccatccgggt tcgagttcaa     3540

gttcaggatc atctcttcct catccctgtc ccacacagca gtgacaccca ctctgtggcc     3600

tggctggccg agcaggcggc ccagcgctac taccagacct gcgggctgct gcccaggctc     3660

accctacgga aagagggggc cctgctggcc ccacaggacc tcatccctga tgtgctgcag     3720

agcaatgacg aggtgttggc tgaggtgact tcgtgggacc tgcccccgtt gactgaccgc     3780

taccgcaggg cctgccagag cctggggcaa ggggagcacc aacaggtgct gcaggccgtg     3840

gagctccagg gcttgggcct ctcgttcagc gcctgctccc tggccctgga ccaggcccag     3900

cttacacccc tgctgcgggc cctcaagctg cacacagcac tccgggagct gcgcctggca     3960

gggaaccggc tgggggacaa gtgtgtggct gagctggtgg ctgccctggg caccatgccc     4020

agcctggccc tccttgacct ctcctccaat cacctgggtc ccgaaggcct gcgccagctt     4080

gccatggggc tcccaggcca agccaccttg cagagtttgg aggaattaga tctatcgatg     4140

aaccccctgg gggacggctg tggccagtcc ctggcctccc tcctgcacgc ctgcccctta     4200

ctcagcaccc tgcgcctgca ggcgtgtggc ttcggcccca gcttctttct gagccaccag     4260

acagcactgg gtagtgcttt ccaagatgct gagcacctga agaccctgtc cctgtcctac     4320

aacgccctgg gagcccctgc cctggccagg accctgcaga gcctgcccgc cggcaccctc     4380

ctgcacttag agctcagctc cgtggcagcc ggcaagggtg attcggacct catggagcct     4440

gtattccgat acctggccaa ggaaggctgt gctctagccc acctgaccct gtctgcaaac     4500

cacctggggg acaaggctgt tagagacctg tgcagatgtc tctctctgtg cccctcactc     4560

atctcactgg atctgtctgc caaccctgag atcagctgtg ccagcttgga agagctcctg     4620

tccaccctcc aaaagcggcc ccaaggcctt agcttccttg gcctgtcagg ctgcgccgtc     4680

cagggtcccc tgggcctggg cctgtgggac aagatagccg cgcagctccg ggaactgcag     4740

ctgtgcagca gacgcctctg cgctgaggac agggacgccc tgcgccagct gcagcccagt     4800

cggccgggcc ccggcgagtg cacgctggac cacggctcca agctcttctt tcggcgcctc     4860

tag                                                                   4863


<210>  9
<211>  4137
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding mutant protein

<400>  9
atgagcctgg agcgcgagct tcgccagctg agcaaggcga aagccaaggc gcagagggcc       60

gggcagcggc gcgaagaggc cgcgctgtgc caccagctgg gggagctcct ggccggccat      120

ggccgctacg ccgaggctct ggagcagcac tggcaggagc tgcagcttcg ggagcgcgct      180

gacgaccctc tgggctgtgc cgtggcccac cgcaagatcg gagagcgcct ggccgagatg      240

gaggactacc cggctgcctt gcagcaccag caccagtacc tggagctggc acattccctg      300

cgcaaccaca cggagctgca gagggcctgg gccaccatcg gccgcaccca cctggacatc      360

tatgaccact gccagtcgag ggatgctttg ctgcaggcac aggctgcctt tgagaagagc      420

ttggctattg tggatgagga gctggagggg acactggccc agggagagct gaatgagatg      480

aggacccgcc tctatctcaa cctgggcctc acctttgaga gcctgcagca gacagccctg      540

tgcaacgatt acttcaggaa gagcatcttc cttgcggagc agaaccacct ttacgaggac      600

ctattccgcg cccgctacaa cctgggcacc atccactggc gcgcgggcca gcactcccag      660

gctatgcgct gcttggaggg tgcccgggag tgtgcgcaca ccatgaggaa gcggttcatg      720

gagagcgagt gctgcgtggt tattgcacag gtcctccaag acctgggaga ctttttggct      780

gccaagcgag ccctgaagaa ggcctacagg ctgggctccc agaagcctgt gcagagggca      840

gccatctgtc agaacctcca gcatgtgctg gcagtggtcc ggctgcagca acagctggaa      900

gaggctgagg gcagagaccc tcagggtgcc atggtcatct gtgagcagct aggggacctc      960

ttctccaagg caggagactt tcccagggca gctgaggctt accagaagca gctgcgtttt     1020

gctgagctgc tggacagacc gggtgctgag cgggccatca tccacgtgtc cctggccacc     1080

acactgggag acatgaagga ccaccatggg gccgtgcgcc actatgagga ggaactgagg     1140

ctgcgcagcg gcaacgtgct ggaggaggcc aagacctggc tgaacattgc actgtcccgc     1200

gaggaggccg gcgatgccta cgagctgctg gccccgtgct tccagaaagc gctcagctgt     1260

gcccagcagg cccagcgtcc ccagctgcag aggcaggtct tgcagcatct ccataccgtg     1320

cagctgaggc tgcagcccca ggaggcccct gagaccgaaa ccagactgcg ggagctcagt     1380

gtagctgaag atgaagatga ggaggaggag gcggaggagg cggcagccac agcggagagc     1440

gaagccctgg aggccggcga ggtggagctc tcagagggcg aggacgacac cgatggcctg     1500

accccgcagc tggaggagga cgaggagctt cagggccacc tgggccggcg gaaggggagc     1560

aagtggaacc ggcgaaacga catgggggag accctgctgc accgagcctg catcgagggc     1620

cagctgcgcc gcgtccagga ccttgtgagg cagggccacc cccttaaccc tcgggactac     1680

tgtggctgga cacctctgca cgcggcctgc aactacgggc atctagaaat tgtccgcttc     1740

ctgctggacc acggggccgc agtggacgac ccaggtggcc agggctgcga aggcatcacc     1800

cccctccacg atgccctcaa ctgtggccac ttcgaggtgg ctgagctgct gcttgaacgg     1860

ggggcgtccg tcaccctccg cactcgaaag ggcctcagcc cgctggagac gctgcagcag     1920

tgggtgaagc tgtaccgcag ggacctggac ctggagacgc ggcagaaggc cagggccatg     1980

gagatgctgc tccaggcggc tgcctcgggc caagatcccc acagctccca ggccttccac     2040

accccaagca gccttctgtt tgaccccgag acctctcctc ctttgagccc ctgcccagaa     2100

cccccctcta atagcactag actcccagag gcctctcagg tccatgtcag ggtctcccca     2160

gggcaggcgg caccagccat ggccaggcct cggaggagca ggcatgggcc agccagcagc     2220

agcagcagct cagaaggcga ggacagcgca ggccccgcac ggccgtccca gaagaggcct     2280

cggtgctcgg ccacagcaca acgggtggca gcctggacgc ctggccccgc cagcaacagg     2340

gaagcagcca cagccagcac cagccgggca gcctaccagg cagccatccg gggtgtgggc     2400

agtgctcaga gccggctggg gcctggccca ccgcggggcc acagcaaagc ccttgccccc     2460

caggcagcgc tcatcccgga ggaggagtgc ctggctgggg actggctgga gctggacatg     2520

cccctgaccc gcagccgccg gccccgcccc cggggcactg gagacaaccg caggcccagt     2580

agtacctctg ggtcggacag tgaggagagc aggccccgtg cccgagccaa gcaggtccgc     2640

ctgacctgca tgcagagttg cagtgcgcca gttaacgcag ggcccagcag cctggcttca     2700

gaacctccag ggagccccag cacccccagg gtctcagagc ccagtgggga cagctctgcg     2760

gcaggccagc ccttgggtcc ggccccgccc cctcccatcc gggttcgagt tcaagttcag     2820

gatcatctct tcctcatccc tgtcccacac agcagtgaca cccactctgt ggcctggctg     2880

gccgagcagg cggcccagcg ctactaccag acctgcgggc tgctgcccag gctcacccta     2940

cggaaagagg gggccctgct ggccccacag gacctcatcc ctgatgtgct gcagagcaat     3000

gacgaggtgt tggctgaggt gacttcgtgg gacctgcccc cgttgactga ccgctaccgc     3060

agggcctgcc agagcctggg gcaaggggag caccaacagg tgctgcaggc cgtggagctc     3120

cagggcttgg gcctctcgtt cagcgcctgc tccctggccc tggaccaggc ccagcttaca     3180

cccctgctgc gggccctcaa gctgcacaca gcactccggg agctgcgcct ggcagggaac     3240

cggctggggg acaagtgtgt ggctgagctg gtggctgccc tgggcaccat gcccagcctg     3300

gccctccttg acctctcctc caatcacctg ggtcccgaag gcctgcgcca gcttgccatg     3360

gggctcccag gccaagccac cttgcagagt ttggaggaat tagatctatc gatgaacccc     3420

ctgggggacg gctgtggcca gtccctggcc tccctcctgc acgcctgccc cttactcagc     3480

accctgcgcc tgcaggcgtg tggcttcggc cccagcttct ttctgagcca ccagacagca     3540

ctgggtagtg ctttccaaga tgctgagcac ctgaagaccc tgtccctgtc ctacaacgcc     3600

ctgggagccc ctgccctggc caggaccctg cagagcctgc ccgccggcac cctcctgcac     3660

ttagagctca gctccgtggc agccggcaag ggtgattcgg acctcatgga gcctgtattc     3720

cgatacctgg ccaaggaagg ctgtgctcta gcccacctga ccctgtctgc aaaccacctg     3780

ggggacaagg ctgttagaga cctgtgcaga tgtctctctc tgtgcccctc actcatctca     3840

ctggatctgt ctgccaaccc tgagatcagc tgtgccagct tggaagagct cctgtccacc     3900

ctccaaaagc ggccccaagg ccttagcttc cttggcctgt caggctgcgc cgtccagggt     3960

cccctgggcc tgggcctgtg ggacaagata gccgcgcagc tccgggaact gcagctgtgc     4020

agcagacgcc tctgcgctga ggacagggac gccctgcgcc agctgcagcc cagtcggccg     4080

ggccccggcg agtgcacgct ggaccacggc tccaagctct tctttcggcg cctctag        4137


<210>  10
<211>  4863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding fusion protein

<400>  10
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggc      720

gcgccaatga gcctggagcg cgagcttcgc cagctgagca aggcgaaagc caaggcgcag      780

agggccgggc agcggcgcga agaggccgcg ctgtgccacc agctggggga gctcctggcc      840

ggccatggcc gctacgccga ggctctggag cagcactggc aggagctgca gcttcgggag      900

cgcgctgacg accctctggg ctgtgccgtg gcccaccgca agatcggaga gcgcctggcc      960

gagatggagg actacccggc tgccttgcag caccagcacc agtacctgga gctggcacat     1020

tccctgcgca accacacgga gctgcagagg gcctgggcca ccatcggccg cacccacctg     1080

gacatctatg accactgcca gtcgagggat gctttgctgc aggcacaggc tgcctttgag     1140

aagagcttgg ctattgtgga tgaggagctg gaggggacac tggcccaggg agagctgaat     1200

gagatgagga cccgcctcta tctcaacctg ggcctcacct ttgagagcct gcagcagaca     1260

gccctgtgca acgattactt caggaagagc atcttccttg cggagcagaa ccacctttac     1320

gaggacctat tccgcgcccg ctacaacctg ggcaccatcc actggcgcgc gggccagcac     1380

tcccaggcta tgcgctgctt ggagggtgcc cgggagtgtg cgcacaccat gaggaagcgg     1440

ttcatggaga gcgagtgctg cgtggttatt gcacaggtcc tccaagacct gggagacttt     1500

ttggctgcca agcgagccct gaagaaggcc tacaggctgg gctcccagaa gcctgtgcag     1560

agggcagcca tctgtcagaa cctccagcat gtgctggcag tggtccggct gcagcaacag     1620

ctggaagagg ctgagggcag agaccctcag ggtgccatgg tcatctgtga gcagctaggg     1680

gacctcttct ccaaggcagg agactttccc agggcagctg aggcttacca gaagcagctg     1740

cgttttgctg agctgctgga cagaccgggt gctgagcggg ccatcatcca cgtgtccctg     1800

gccaccacac tgggagacat gaaggaccac catggggccg tgcgccacta tgaggaggaa     1860

ctgaggctgc gcagcggcaa cgtgctggag gaggccaaga cctggctgaa cattgcactg     1920

tcccgcgagg aggccggcga tgcctacgag ctgctggccc cgtgcttcca gaaagcgctc     1980

agctgtgccc agcaggccca gcgtccccag ctgcagaggc aggtcttgca gcatctccat     2040

accgtgcagc tgaggctgca gccccaggag gcccctgaga ccgaaaccag actgcgggag     2100

ctcagtgtag ctgaagatga agatgaggag gaggaggcgg aggaggcggc agccacagcg     2160

gagagcgaag ccctggaggc cggcgaggtg gagctctcag agggcgagga cgacaccgat     2220

ggcctgaccc cgcagctgga ggaggacgag gagcttcagg gccacctggg ccggcggaag     2280

gggagcaagt ggaaccggcg aaacgacatg ggggagaccc tgctgcaccg agcctgcatc     2340

gagggccagc tgcgccgcgt ccaggacctt gtgaggcagg gccaccccct taaccctcgg     2400

gactactgtg gctggacacc tctgcacgcg gcctgcaact acgggcatct agaaattgtc     2460

cgcttcctgc tggaccacgg ggccgcagtg gacgacccag gtggccaggg ctgcgaaggc     2520

atcacccccc tccacgatgc cctcaactgt ggccacttcg aggtggctga gctgctgctt     2580

gaacgggggg cgtccgtcac cctccgcact cgaaagggcc tcagcccgct ggagacgctg     2640

cagcagtggg tgaagctgta ccgcagggac ctggacctgg agacgcggca gaaggccagg     2700

gccatggaga tgctgctcca ggcggctgcc tcgggccaag atccccacag ctcccaggcc     2760

ttccacaccc caagcagcct tctgtttgac cccgagacct ctcctccttt gagcccctgc     2820

ccagaacccc cctctaatag cactagactc ccagaggcct ctcaggtcca tgtcagggtc     2880

tccccagggc aggcggcacc agccatggcc aggcctcgga ggagcaggca tgggccagcc     2940

agcagcagca gcagctcaga aggcgaggac agcgcaggcc ccgcacggcc gtcccagaag     3000

aggcctcggt gctcggccac agcacaacgg gtggcagcct ggacgcctgg ccccgccagc     3060

aacagggaag cagccacagc cagcaccagc cgggcagcct accaggcagc catccggggt     3120

gtgggcagtg ctcagagccg gctggggcct ggcccaccgc ggggccacag caaagccctt     3180

gccccccagg cagcgctcat cccggaggag gagtgcctgg ctggggactg gctggagctg     3240

gacatgcccc tgacccgcag ccgccggccc cgcccccggg gcactggaga caaccgcagg     3300

cccagtagta cctctgggtc ggacagtgag gagagcaggc cccgtgcccg agccaagcag     3360

gtccgcctga cctgcatgca gagttgcagt gcgccagtta acgcagggcc cagcagcctg     3420

gcttcagaac ctccagggag ccccagcacc cccagggtct cagagcccag tggggacagc     3480

tctgcggcag gccagccctt gggtccggcc ccgccccctc ccatccgggt tcgagttcaa     3540

gttcaggatc atctcttcct catccctgtc ccacacagca gtgacaccca ctctgtggcc     3600

tggctggccg agcaggcggc ccagcgctac taccagacct gcgggctgct gcccaggctc     3660

accctacgga aagagggggc cctgctggcc ccacaggacc tcatccctga tgtgctgcag     3720

agcaatgacg aggtgttggc tgaggtgact tcgtgggacc tgcccccgtt gactgaccgc     3780

taccgcaggg cctgccagag cctggggcaa ggggagcacc aacaggtgct gcaggccgtg     3840

gagctccagg gcttgggcct ctcgttcagc gcctgctccc tggccctgga ccaggcccag     3900

cttacacccc tgctgcgggc cctcaagctg cacacagcac tccgggagct gcgcctggca     3960

gggaaccggc tgggggacaa gtgtgtggct gagctggtgg ctgccctggg caccatgccc     4020

agcctggccc tccttgacct ctcctccaat cacctgggtc ccgaaggcct gcgccagctt     4080

gccatggggc tcccaggcca agccaccttg cagagtttgg aggaattaga tctatcgatg     4140

aaccccctgg gggacggctg tggccagtcc ctggcctccc tcctgcacgc ctgcccctta     4200

ctcagcaccc tgcgcctgca ggcgtgtggc ttcggcccca gcttctttct gagccaccag     4260

acagcactgg gtagtgcttt ccaagatgct gagcacctga agaccctgtc cctgtcctac     4320

aacgccctgg gagcccctgc cctggccagg accctgcaga gcctgcccgc cggcaccctc     4380

ctgcacttag agctcagctc cgtggcagcc ggcaagggtg attcggacct catggagcct     4440

gtattccgat acctggccaa ggaaggctgt gctctagccc acctgaccct gtctgcaaac     4500

cacctggggg acaaggctgt tagagacctg tgcagatgtc tctctctgtg cccctcactc     4560

atctcactgg atctgtctgc caaccctgag atcagctgtg ccagcttgga agagctcctg     4620

tccaccctcc aaaagcggcc ccaaggcctt agcttccttg gcctgtcagg ctgcgccgtc     4680

cagggtcccc tgggcctggg cctgtgggac aagatagccg cgcagctccg ggaactgcag     4740

ctgtgcagca gacgcctctg cgctgaggac agggacgccc tgcgccagct gcagcccagt     4800

cggccgggcc ccggcgagtg cacgctggac cacggctcca agctcttctt tcggcgcctc     4860

tag                                                                   4863


<210>  11
<211>  4137
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding mutant protein

<400>  11
atgagcctgg agcgcgagct tcgccagctg agcaaggcga aagccaaggc gcagagggcc       60

gggcagcggc gcgaagaggc cgcgctgtgc caccagctgg gggagctcct ggccggccat      120

ggccgctacg ccgaggctct ggagcagcac tggcaggagc tgcagcttcg ggagcgcgct      180

gacgaccctc tgggctgtgc cgtggcccac cgcaagatcg gagagcgcct ggccgagatg      240

gaggactacc cggctgcctt gcagcaccag caccagtacc tggagctggc acattccctg      300

cgcaaccaca cggagctgca gagggcctgg gccaccatcg gccgcaccca cctggacatc      360

tatgaccact gccagtcgag ggatgctttg ctgcaggcac aggctgcctt tgagaagagc      420

ttggctattg tggatgagga gctggagggg acactggccc agggagagct gaatgagatg      480

aggacccgcc tctatctcaa cctgggcctc acctttgaga gcctgcagca gacagccctg      540

tgcaacgatt acttcaggaa gagcatcttc cttgcggagc agaaccacct ttacgaggac      600

ctattccgcg cccgctacaa cctgggcacc atccactggc gcgcgggcca gcactcccag      660

gctatgcgct gcttggaggg tgcccgggag tgtgcgcaca ccatgaggaa gcggttcatg      720

gagagcgagt gctgcgtggt tattgcacag gtcctccaag acctgggaga ctttttggct      780

gccaagcgag ccctgaagaa ggcctacagg ctgggctccc agaagcctgt gcagagggca      840

gccatctgtc agaacctcca gcatgtgctg gcagtggtcc ggctgcagca acagctggaa      900

gaggctgagg gcagagaccc tcagggtgcc atggtcatct gtgagcagct aggggacctc      960

ttctccaagg caggagactt tcccagggca gctgaggctt accagaagca gctgcgtttt     1020

gctgagctgc tggacagacc gggtgctgag cgggccatca tccacgtgtc cctggccacc     1080

acactgggag acatgaagga ccaccatggg gccgtgcgcc actatgagga ggaactgagg     1140

ctgcgcagcg gcaacgtgct ggaggaggcc aagacctggc tgaacattgc actgtcccgc     1200

gaggaggccg gcgatgccta cgagctgctg gccccgtgct tccagaaagc gctcagctgt     1260

gcccagcagg cccagcgtcc ccagctgcag aggcaggtct tgcagcatct ccataccgtg     1320

cagctgaggc tgcagcccca ggaggcccct gagaccgaaa ccagactgcg ggagctcagt     1380

gtagctgaag atgaagatga ggaggaggag gcggaggagg cggcagccac agcggagagc     1440

gaagccctgg aggccggcga ggtggagctc tcagagggcg aggacgacac cgatggcctg     1500

accccgcagc tggaggagga cgaggagctt cagggccacc tgggccggcg gaaggggagc     1560

aagtggaacc ggcgaaacga catgggggag accctgctgc accgagcctg catcgagggc     1620

cagctgcgcc gcgtccagga ccttgtgagg cagggccacc cccttaaccc tcgggactac     1680

tgtggctgga cacctctgca cgaggcctgc gcctacgggc atctagaaat tgtccgcttc     1740

ctgctggacc acggggccgc agtggacgac ccaggtggcc agggctgcga aggcatcacc     1800

cccctccacg atgccctcaa ctgtggccac ttcgaggtgg ctgagctgct gcttgaacgg     1860

ggggcgtccg tcaccctccg cactcgaaag ggcctcagcc cgctggagac gctgcagcag     1920

tgggtgaagc tgtaccgcag ggacctggac ctggagacgc ggcagaaggc cagggccatg     1980

gagatgctgc tccaggcggc tgcctcgggc caagatcccc acagctccca ggccttccac     2040

accccaagca gccttctgtt tgaccccgag acctctcctc ctttgagccc ctgcccagaa     2100

cccccctcta atagcactag actcccagag gcctctcagg tccatgtcag ggtctcccca     2160

gggcaggcgg caccagccat ggccaggcct cggaggagca ggcatgggcc agccagcagc     2220

agcagcagct cagaaggcga ggacagcgca ggccccgcac ggccgtccca gaagaggcct     2280

cggtgctcgg ccacagcaca acgggtggca gcctggacgc ctggccccgc cagcaacagg     2340

gaagcagcca cagccagcac cagccgggca gcctaccagg cagccatccg gggtgtgggc     2400

agtgctcaga gccggctggg gcctggccca ccgcggggcc acagcaaagc ccttgccccc     2460

caggcagcgc tcatcccgga ggaggagtgc ctggctgggg actggctgga gctggacatg     2520

cccctgaccc gcagccgccg gccccgcccc cggggcactg gagacaaccg caggcccagt     2580

agtacctctg ggtcggacag tgaggagagc aggccccgtg cccgagccaa gcaggtccgc     2640

ctgacctgca tgcagagttg cagtgcgcca gttaacgcag ggcccagcag cctggcttca     2700

gaacctccag ggagccccag cacccccagg gtctcagagc ccagtgggga cagctctgcg     2760

gcaggccagc ccttgggtcc ggccccgccc cctcccatcc gggttcgagt tcaagttcag     2820

gatcatctct tcctcatccc tgtcccacac agcagtgaca cccactctgt ggcctggctg     2880

gccgagcagg cggcccagcg ctactaccag acctgcgggc tgctgcccag gctcacccta     2940

cggaaagagg gggccctgct ggccccacag gacctcatcc ctgatgtgct gcagagcaat     3000

gacgaggtgt tggctgaggt gacttcgtgg gacctgcccc cgttgactga ccgctaccgc     3060

agggcctgcc agagcctggg gcaaggggag caccaacagg tgctgcaggc cgtggagctc     3120

cagggcttgg gcctctcgtt cagcgcctgc tccctggccc tggaccaggc ccagcttaca     3180

cccctgctgc gggccctcaa gctgcacaca gcactccggg agctgcgcct ggcagggaac     3240

cggctggggg acaagtgtgt ggctgagctg gtggctgccc tgggcaccat gcccagcctg     3300

gccctccttg acctctcctc caatcacctg ggtcccgaag gcctgcgcca gcttgccatg     3360

gggctcccag gccaagccac cttgcagagt ttggaggaat tagatctatc gatgaacccc     3420

ctgggggacg gctgtggcca gtccctggcc tccctcctgc acgcctgccc cttactcagc     3480

accctgcgcc tgcaggcgtg tggcttcggc cccagcttct ttctgagcca ccagacagca     3540

ctgggtagtg ctttccaaga tgctgagcac ctgaagaccc tgtccctgtc ctacaacgcc     3600

ctgggagccc ctgccctggc caggaccctg cagagcctgc ccgccggcac cctcctgcac     3660

ttagagctca gctccgtggc agccggcaag ggtgattcgg acctcatgga gcctgtattc     3720

cgatacctgg ccaaggaagg ctgtgctcta gcccacctga ccctgtctgc aaaccacctg     3780

ggggacaagg ctgttagaga cctgtgcaga tgtctctctc tgtgcccctc actcatctca     3840

ctggatctgt ctgccaaccc tgagatcagc tgtgccagct tggaagagct cctgtccacc     3900

ctccaaaagc ggccccaagg ccttagcttc cttggcctgt caggctgcgc cgtccagggt     3960

cccctgggcc tgggcctgtg ggacaagata gccgcgcagc tccgggaact gcagctgtgc     4020

agcagacgcc tctgcgctga ggacagggac gccctgcgcc agctgcagcc cagtcggccg     4080

ggccccggcg agtgcacgct ggaccacggc tccaagctct tctttcggcg cctctag        4137


<210>  12
<211>  4863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding fusion protein

<400>  12
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggc      720

gcgccaatga gcctggagcg cgagcttcgc cagctgagca aggcgaaagc caaggcgcag      780

agggccgggc agcggcgcga agaggccgcg ctgtgccacc agctggggga gctcctggcc      840

ggccatggcc gctacgccga ggctctggag cagcactggc aggagctgca gcttcgggag      900

cgcgctgacg accctctggg ctgtgccgtg gcccaccgca agatcggaga gcgcctggcc      960

gagatggagg actacccggc tgccttgcag caccagcacc agtacctgga gctggcacat     1020

tccctgcgca accacacgga gctgcagagg gcctgggcca ccatcggccg cacccacctg     1080

gacatctatg accactgcca gtcgagggat gctttgctgc aggcacaggc tgcctttgag     1140

aagagcttgg ctattgtgga tgaggagctg gaggggacac tggcccaggg agagctgaat     1200

gagatgagga cccgcctcta tctcaacctg ggcctcacct ttgagagcct gcagcagaca     1260

gccctgtgca acgattactt caggaagagc atcttccttg cggagcagaa ccacctttac     1320

gaggacctat tccgcgcccg ctacaacctg ggcaccatcc actggcgcgc gggccagcac     1380

tcccaggcta tgcgctgctt ggagggtgcc cgggagtgtg cgcacaccat gaggaagcgg     1440

ttcatggaga gcgagtgctg cgtggttatt gcacaggtcc tccaagacct gggagacttt     1500

ttggctgcca agcgagccct gaagaaggcc tacaggctgg gctcccagaa gcctgtgcag     1560

agggcagcca tctgtcagaa cctccagcat gtgctggcag tggtccggct gcagcaacag     1620

ctggaagagg ctgagggcag agaccctcag ggtgccatgg tcatctgtga gcagctaggg     1680

gacctcttct ccaaggcagg agactttccc agggcagctg aggcttacca gaagcagctg     1740

cgttttgctg agctgctgga cagaccgggt gctgagcggg ccatcatcca cgtgtccctg     1800

gccaccacac tgggagacat gaaggaccac catggggccg tgcgccacta tgaggaggaa     1860

ctgaggctgc gcagcggcaa cgtgctggag gaggccaaga cctggctgaa cattgcactg     1920

tcccgcgagg aggccggcga tgcctacgag ctgctggccc cgtgcttcca gaaagcgctc     1980

agctgtgccc agcaggccca gcgtccccag ctgcagaggc aggtcttgca gcatctccat     2040

accgtgcagc tgaggctgca gccccaggag gcccctgaga ccgaaaccag actgcgggag     2100

ctcagtgtag ctgaagatga agatgaggag gaggaggcgg aggaggcggc agccacagcg     2160

gagagcgaag ccctggaggc cggcgaggtg gagctctcag agggcgagga cgacaccgat     2220

ggcctgaccc cgcagctgga ggaggacgag gagcttcagg gccacctggg ccggcggaag     2280

gggagcaagt ggaaccggcg aaacgacatg ggggagaccc tgctgcaccg agcctgcatc     2340

gagggccagc tgcgccgcgt ccaggacctt gtgaggcagg gccaccccct taaccctcgg     2400

gactactgtg gctggacacc tctgcacgag gcctgcgcct acgggcatct agaaattgtc     2460

cgcttcctgc tggaccacgg ggccgcagtg gacgacccag gtggccaggg ctgcgaaggc     2520

atcacccccc tccacgatgc cctcaactgt ggccacttcg aggtggctga gctgctgctt     2580

gaacgggggg cgtccgtcac cctccgcact cgaaagggcc tcagcccgct ggagacgctg     2640

cagcagtggg tgaagctgta ccgcagggac ctggacctgg agacgcggca gaaggccagg     2700

gccatggaga tgctgctcca ggcggctgcc tcgggccaag atccccacag ctcccaggcc     2760

ttccacaccc caagcagcct tctgtttgac cccgagacct ctcctccttt gagcccctgc     2820

ccagaacccc cctctaatag cactagactc ccagaggcct ctcaggtcca tgtcagggtc     2880

tccccagggc aggcggcacc agccatggcc aggcctcgga ggagcaggca tgggccagcc     2940

agcagcagca gcagctcaga aggcgaggac agcgcaggcc ccgcacggcc gtcccagaag     3000

aggcctcggt gctcggccac agcacaacgg gtggcagcct ggacgcctgg ccccgccagc     3060

aacagggaag cagccacagc cagcaccagc cgggcagcct accaggcagc catccggggt     3120

gtgggcagtg ctcagagccg gctggggcct ggcccaccgc ggggccacag caaagccctt     3180

gccccccagg cagcgctcat cccggaggag gagtgcctgg ctggggactg gctggagctg     3240

gacatgcccc tgacccgcag ccgccggccc cgcccccggg gcactggaga caaccgcagg     3300

cccagtagta cctctgggtc ggacagtgag gagagcaggc cccgtgcccg agccaagcag     3360

gtccgcctga cctgcatgca gagttgcagt gcgccagtta acgcagggcc cagcagcctg     3420

gcttcagaac ctccagggag ccccagcacc cccagggtct cagagcccag tggggacagc     3480

tctgcggcag gccagccctt gggtccggcc ccgccccctc ccatccgggt tcgagttcaa     3540

gttcaggatc atctcttcct catccctgtc ccacacagca gtgacaccca ctctgtggcc     3600

tggctggccg agcaggcggc ccagcgctac taccagacct gcgggctgct gcccaggctc     3660

accctacgga aagagggggc cctgctggcc ccacaggacc tcatccctga tgtgctgcag     3720

agcaatgacg aggtgttggc tgaggtgact tcgtgggacc tgcccccgtt gactgaccgc     3780

taccgcaggg cctgccagag cctggggcaa ggggagcacc aacaggtgct gcaggccgtg     3840

gagctccagg gcttgggcct ctcgttcagc gcctgctccc tggccctgga ccaggcccag     3900

cttacacccc tgctgcgggc cctcaagctg cacacagcac tccgggagct gcgcctggca     3960

gggaaccggc tgggggacaa gtgtgtggct gagctggtgg ctgccctggg caccatgccc     4020

agcctggccc tccttgacct ctcctccaat cacctgggtc ccgaaggcct gcgccagctt     4080

gccatggggc tcccaggcca agccaccttg cagagtttgg aggaattaga tctatcgatg     4140

aaccccctgg gggacggctg tggccagtcc ctggcctccc tcctgcacgc ctgcccctta     4200

ctcagcaccc tgcgcctgca ggcgtgtggc ttcggcccca gcttctttct gagccaccag     4260

acagcactgg gtagtgcttt ccaagatgct gagcacctga agaccctgtc cctgtcctac     4320

aacgccctgg gagcccctgc cctggccagg accctgcaga gcctgcccgc cggcaccctc     4380

ctgcacttag agctcagctc cgtggcagcc ggcaagggtg attcggacct catggagcct     4440

gtattccgat acctggccaa ggaaggctgt gctctagccc acctgaccct gtctgcaaac     4500

cacctggggg acaaggctgt tagagacctg tgcagatgtc tctctctgtg cccctcactc     4560

atctcactgg atctgtctgc caaccctgag atcagctgtg ccagcttgga agagctcctg     4620

tccaccctcc aaaagcggcc ccaaggcctt agcttccttg gcctgtcagg ctgcgccgtc     4680

cagggtcccc tgggcctggg cctgtgggac aagatagccg cgcagctccg ggaactgcag     4740

ctgtgcagca gacgcctctg cgctgaggac agggacgccc tgcgccagct gcagcccagt     4800

cggccgggcc ccggcgagtg cacgctggac cacggctcca agctcttctt tcggcgcctc     4860

tag                                                                   4863


<210>  13
<211>  4137
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding mutant protein

<400>  13
atgagcctgg agcgcgagct tcgccagctg agcaaggcga aagccaaggc gcagagggcc       60

gggcagcggc gcgaagaggc cgcgctgtgc caccagctgg gggagctcct ggccggccat      120

ggccgctacg ccgaggctct ggagcagcac tggcaggagc tgcagcttcg ggagcgcgct      180

gacgaccctc tgggctgtgc cgtggcccac cgcaagatcg gagagcgcct ggccgagatg      240

gaggactacc cggctgcctt gcagcaccag caccagtacc tggagctggc acattccctg      300

cgcaaccaca cggagctgca gagggcctgg gccaccatcg gccgcaccca cctggacatc      360

tatgaccact gccagtcgag ggatgctttg ctgcaggcac aggctgcctt tgagaagagc      420

ttggctattg tggatgagga gctggagggg acactggccc agggagagct gaatgagatg      480

aggacccgcc tctatctcaa cctgggcctc acctttgaga gcctgcagca gacagccctg      540

tgcaacgatt acttcaggaa gagcatcttc cttgcggagc agaaccacct ttacgaggac      600

ctattccgcg cccgctacaa cctgggcacc atccactggc gcgcgggcca gcactcccag      660

gctatgcgct gcttggaggg tgcccgggag tgtgcgcaca ccatgaggaa gcggttcatg      720

gagagcgagt gctgcgtggt tattgcacag gtcctccaag acctgggaga ctttttggct      780

gccaagcgag ccctgaagaa ggcctacagg ctgggctccc agaagcctgt gcagagggca      840

gccatctgtc agaacctcca gcatgtgctg gcagtggtcc ggctgcagca acagctggaa      900

gaggctgagg gcagagaccc tcagggtgcc atggtcatct gtgagcagct aggggacctc      960

ttctccaagg caggagactt tcccagggca gctgaggctt accagaagca gctgcgtttt     1020

gctgagctgc tggacagacc gggtgctgag cgggccatca tccacgtgtc cctggccacc     1080

acactgggag acatgaagga ccaccatggg gccgtgcgcc actatgagga ggaactgagg     1140

ctgcgcagcg gcaacgtgct ggaggaggcc aagacctggc tgaacattgc actgtcccgc     1200

gaggaggccg gcgatgccta cgagctgctg gccccgtgct tccagaaagc gctcagctgt     1260

gcccagcagg cccagcgtcc ccagctgcag aggcaggtct tgcagcatct ccataccgtg     1320

cagctgaggc tgcagcccca ggaggcccct gagaccgaaa ccagactgcg ggagctcagt     1380

gtagctgaag atgaagatga ggaggaggag gcggaggagg cggcagccac agcggagagc     1440

gaagccctgg aggccggcga ggtggagctc tcagagggcg aggacgacac cgatggcctg     1500

accccgcagc tggaggagga cgaggagctt cagggccacc tgggccggcg gaaggggagc     1560

aagtggaacc ggcgaaacga catgggggag accctgctgc accgagcctg catcgagggc     1620

cagctgcgcc gcgtccagga ccttgtgagg cagggccacc cccttaaccc tcgggactac     1680

tgtggctgga cacctctgca cgaggcctgc aactacgggc atctagaaat tgtccgcttc     1740

ctgctggacc acggggccgc agtggacgac ccaggtggcc agggctgcga aggcatcacc     1800

cccctccacg ctgccctcaa ctgtggccac ttcgaggtgg ctgagctgct gcttgaacgg     1860

ggggcgtccg tcaccctccg cactcgaaag ggcctcagcc cgctggagac gctgcagcag     1920

tgggtgaagc tgtaccgcag ggacctggac ctggagacgc ggcagaaggc cagggccatg     1980

gagatgctgc tccaggcggc tgcctcgggc caagatcccc acagctccca ggccttccac     2040

accccaagca gccttctgtt tgaccccgag acctctcctc ctttgagccc ctgcccagaa     2100

cccccctcta atagcactag actcccagag gcctctcagg tccatgtcag ggtctcccca     2160

gggcaggcgg caccagccat ggccaggcct cggaggagca ggcatgggcc agccagcagc     2220

agcagcagct cagaaggcga ggacagcgca ggccccgcac ggccgtccca gaagaggcct     2280

cggtgctcgg ccacagcaca acgggtggca gcctggacgc ctggccccgc cagcaacagg     2340

gaagcagcca cagccagcac cagccgggca gcctaccagg cagccatccg gggtgtgggc     2400

agtgctcaga gccggctggg gcctggccca ccgcggggcc acagcaaagc ccttgccccc     2460

caggcagcgc tcatcccgga ggaggagtgc ctggctgggg actggctgga gctggacatg     2520

cccctgaccc gcagccgccg gccccgcccc cggggcactg gagacaaccg caggcccagt     2580

agtacctctg ggtcggacag tgaggagagc aggccccgtg cccgagccaa gcaggtccgc     2640

ctgacctgca tgcagagttg cagtgcgcca gttaacgcag ggcccagcag cctggcttca     2700

gaacctccag ggagccccag cacccccagg gtctcagagc ccagtgggga cagctctgcg     2760

gcaggccagc ccttgggtcc ggccccgccc cctcccatcc gggttcgagt tcaagttcag     2820

gatcatctct tcctcatccc tgtcccacac agcagtgaca cccactctgt ggcctggctg     2880

gccgagcagg cggcccagcg ctactaccag acctgcgggc tgctgcccag gctcacccta     2940

cggaaagagg gggccctgct ggccccacag gacctcatcc ctgatgtgct gcagagcaat     3000

gacgaggtgt tggctgaggt gacttcgtgg gacctgcccc cgttgactga ccgctaccgc     3060

agggcctgcc agagcctggg gcaaggggag caccaacagg tgctgcaggc cgtggagctc     3120

cagggcttgg gcctctcgtt cagcgcctgc tccctggccc tggaccaggc ccagcttaca     3180

cccctgctgc gggccctcaa gctgcacaca gcactccggg agctgcgcct ggcagggaac     3240

cggctggggg acaagtgtgt ggctgagctg gtggctgccc tgggcaccat gcccagcctg     3300

gccctccttg acctctcctc caatcacctg ggtcccgaag gcctgcgcca gcttgccatg     3360

gggctcccag gccaagccac cttgcagagt ttggaggaat tagatctatc gatgaacccc     3420

ctgggggacg gctgtggcca gtccctggcc tccctcctgc acgcctgccc cttactcagc     3480

accctgcgcc tgcaggcgtg tggcttcggc cccagcttct ttctgagcca ccagacagca     3540

ctgggtagtg ctttccaaga tgctgagcac ctgaagaccc tgtccctgtc ctacaacgcc     3600

ctgggagccc ctgccctggc caggaccctg cagagcctgc ccgccggcac cctcctgcac     3660

ttagagctca gctccgtggc agccggcaag ggtgattcgg acctcatgga gcctgtattc     3720

cgatacctgg ccaaggaagg ctgtgctcta gcccacctga ccctgtctgc aaaccacctg     3780

ggggacaagg ctgttagaga cctgtgcaga tgtctctctc tgtgcccctc actcatctca     3840

ctggatctgt ctgccaaccc tgagatcagc tgtgccagct tggaagagct cctgtccacc     3900

ctccaaaagc ggccccaagg ccttagcttc cttggcctgt caggctgcgc cgtccagggt     3960

cccctgggcc tgggcctgtg ggacaagata gccgcgcagc tccgggaact gcagctgtgc     4020

agcagacgcc tctgcgctga ggacagggac gccctgcgcc agctgcagcc cagtcggccg     4080

ggccccggcg agtgcacgct ggaccacggc tccaagctct tctttcggcg cctctag        4137


<210>  14
<211>  4863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding fusion protein

<400>  14
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagggc      720

gcgccaatga gcctggagcg cgagcttcgc cagctgagca aggcgaaagc caaggcgcag      780

agggccgggc agcggcgcga agaggccgcg ctgtgccacc agctggggga gctcctggcc      840

ggccatggcc gctacgccga ggctctggag cagcactggc aggagctgca gcttcgggag      900

cgcgctgacg accctctggg ctgtgccgtg gcccaccgca agatcggaga gcgcctggcc      960

gagatggagg actacccggc tgccttgcag caccagcacc agtacctgga gctggcacat     1020

tccctgcgca accacacgga gctgcagagg gcctgggcca ccatcggccg cacccacctg     1080

gacatctatg accactgcca gtcgagggat gctttgctgc aggcacaggc tgcctttgag     1140

aagagcttgg ctattgtgga tgaggagctg gaggggacac tggcccaggg agagctgaat     1200

gagatgagga cccgcctcta tctcaacctg ggcctcacct ttgagagcct gcagcagaca     1260

gccctgtgca acgattactt caggaagagc atcttccttg cggagcagaa ccacctttac     1320

gaggacctat tccgcgcccg ctacaacctg ggcaccatcc actggcgcgc gggccagcac     1380

tcccaggcta tgcgctgctt ggagggtgcc cgggagtgtg cgcacaccat gaggaagcgg     1440

ttcatggaga gcgagtgctg cgtggttatt gcacaggtcc tccaagacct gggagacttt     1500

ttggctgcca agcgagccct gaagaaggcc tacaggctgg gctcccagaa gcctgtgcag     1560

agggcagcca tctgtcagaa cctccagcat gtgctggcag tggtccggct gcagcaacag     1620

ctggaagagg ctgagggcag agaccctcag ggtgccatgg tcatctgtga gcagctaggg     1680

gacctcttct ccaaggcagg agactttccc agggcagctg aggcttacca gaagcagctg     1740

cgttttgctg agctgctgga cagaccgggt gctgagcggg ccatcatcca cgtgtccctg     1800

gccaccacac tgggagacat gaaggaccac catggggccg tgcgccacta tgaggaggaa     1860

ctgaggctgc gcagcggcaa cgtgctggag gaggccaaga cctggctgaa cattgcactg     1920

tcccgcgagg aggccggcga tgcctacgag ctgctggccc cgtgcttcca gaaagcgctc     1980

agctgtgccc agcaggccca gcgtccccag ctgcagaggc aggtcttgca gcatctccat     2040

accgtgcagc tgaggctgca gccccaggag gcccctgaga ccgaaaccag actgcgggag     2100

ctcagtgtag ctgaagatga agatgaggag gaggaggcgg aggaggcggc agccacagcg     2160

gagagcgaag ccctggaggc cggcgaggtg gagctctcag agggcgagga cgacaccgat     2220

ggcctgaccc cgcagctgga ggaggacgag gagcttcagg gccacctggg ccggcggaag     2280

gggagcaagt ggaaccggcg aaacgacatg ggggagaccc tgctgcaccg agcctgcatc     2340

gagggccagc tgcgccgcgt ccaggacctt gtgaggcagg gccaccccct taaccctcgg     2400

gactactgtg gctggacacc tctgcacgag gcctgcaact acgggcatct agaaattgtc     2460

cgcttcctgc tggaccacgg ggccgcagtg gacgacccag gtggccaggg ctgcgaaggc     2520

atcacccccc tccacgctgc cctcaactgt ggccacttcg aggtggctga gctgctgctt     2580

gaacgggggg cgtccgtcac cctccgcact cgaaagggcc tcagcccgct ggagacgctg     2640

cagcagtggg tgaagctgta ccgcagggac ctggacctgg agacgcggca gaaggccagg     2700

gccatggaga tgctgctcca ggcggctgcc tcgggccaag atccccacag ctcccaggcc     2760

ttccacaccc caagcagcct tctgtttgac cccgagacct ctcctccttt gagcccctgc     2820

ccagaacccc cctctaatag cactagactc ccagaggcct ctcaggtcca tgtcagggtc     2880

tccccagggc aggcggcacc agccatggcc aggcctcgga ggagcaggca tgggccagcc     2940

agcagcagca gcagctcaga aggcgaggac agcgcaggcc ccgcacggcc gtcccagaag     3000

aggcctcggt gctcggccac agcacaacgg gtggcagcct ggacgcctgg ccccgccagc     3060

aacagggaag cagccacagc cagcaccagc cgggcagcct accaggcagc catccggggt     3120

gtgggcagtg ctcagagccg gctggggcct ggcccaccgc ggggccacag caaagccctt     3180

gccccccagg cagcgctcat cccggaggag gagtgcctgg ctggggactg gctggagctg     3240

gacatgcccc tgacccgcag ccgccggccc cgcccccggg gcactggaga caaccgcagg     3300

cccagtagta cctctgggtc ggacagtgag gagagcaggc cccgtgcccg agccaagcag     3360

gtccgcctga cctgcatgca gagttgcagt gcgccagtta acgcagggcc cagcagcctg     3420

gcttcagaac ctccagggag ccccagcacc cccagggtct cagagcccag tggggacagc     3480

tctgcggcag gccagccctt gggtccggcc ccgccccctc ccatccgggt tcgagttcaa     3540

gttcaggatc atctcttcct catccctgtc ccacacagca gtgacaccca ctctgtggcc     3600

tggctggccg agcaggcggc ccagcgctac taccagacct gcgggctgct gcccaggctc     3660

accctacgga aagagggggc cctgctggcc ccacaggacc tcatccctga tgtgctgcag     3720

agcaatgacg aggtgttggc tgaggtgact tcgtgggacc tgcccccgtt gactgaccgc     3780

taccgcaggg cctgccagag cctggggcaa ggggagcacc aacaggtgct gcaggccgtg     3840

gagctccagg gcttgggcct ctcgttcagc gcctgctccc tggccctgga ccaggcccag     3900

cttacacccc tgctgcgggc cctcaagctg cacacagcac tccgggagct gcgcctggca     3960

gggaaccggc tgggggacaa gtgtgtggct gagctggtgg ctgccctggg caccatgccc     4020

agcctggccc tccttgacct ctcctccaat cacctgggtc ccgaaggcct gcgccagctt     4080

gccatggggc tcccaggcca agccaccttg cagagtttgg aggaattaga tctatcgatg     4140

aaccccctgg gggacggctg tggccagtcc ctggcctccc tcctgcacgc ctgcccctta     4200

ctcagcaccc tgcgcctgca ggcgtgtggc ttcggcccca gcttctttct gagccaccag     4260

acagcactgg gtagtgcttt ccaagatgct gagcacctga agaccctgtc cctgtcctac     4320

aacgccctgg gagcccctgc cctggccagg accctgcaga gcctgcccgc cggcaccctc     4380

ctgcacttag agctcagctc cgtggcagcc ggcaagggtg attcggacct catggagcct     4440

gtattccgat acctggccaa ggaaggctgt gctctagccc acctgaccct gtctgcaaac     4500

cacctggggg acaaggctgt tagagacctg tgcagatgtc tctctctgtg cccctcactc     4560

atctcactgg atctgtctgc caaccctgag atcagctgtg ccagcttgga agagctcctg     4620

tccaccctcc aaaagcggcc ccaaggcctt agcttccttg gcctgtcagg ctgcgccgtc     4680

cagggtcccc tgggcctggg cctgtgggac aagatagccg cgcagctccg ggaactgcag     4740

ctgtgcagca gacgcctctg cgctgaggac agggacgccc tgcgccagct gcagcccagt     4800

cggccgggcc ccggcgagtg cacgctggac cacggctcca agctcttctt tcggcgcctc     4860

tag                                                                   4863


<210>  15
<211>  780
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding fusion protein

<400>  15
ggatccgggc ccctggagga agaagaggat ggagaggagc tcattggaga tggcatggaa       60

agggactacc gcgccatccc agagctggac gcctatgagg ccgagggact ggctctggat      120

gatgaggacg tagaggagct gacggccagt cagagggagg cagcagagcg ggccatgcgg      180

cagcgtgacc gggaggctgg ccggggcctg ggccgaggag gtggaggtgg ccacctgggc      240

cggcggaagg ggagcaagtg gaaccggcga aacgacatgg gggagaccct gctgcaccga      300

gcctgcatcg agggccagct gcgccgcgtc caggaccttg tgaggcaggg ccaccccctt      360

aaccctcggg actactgtgg ctggacacct ctgcacgagg cctgcaacta cgggcatcta      420

gaaattgtcc gcttcctgct ggaccacggg gccgcagtgg acgacccagg tggccagggc      480

tgcgaaggca tcacccccct ccacgatgcc ctcaactgtg gccacttcga ggtggctgag      540

ctgctgcttg aacggggggc gtccgtcacc ctccgcactc gaaagggcct cagcccgctg      600

gagacgctgc agcagtgggt gaagctgtac cgcagggacc tggacctgga gacgcggcag      660

aaggccaggg ccatggagat gctgctccag gcggctgcct cgggccaaga tccccacagc      720

tcccaggcct tccacacccc aagcagcctt ctgtttgacc ccgagacctc ttaactcgag      780


<210>  16
<211>  1378
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Leu Glu Arg Glu Leu Arg Gln Leu Ser Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Gln Arg Ala Gly Gln Arg Arg Glu Glu Ala Ala Leu Cys His Gln 
            20                  25                  30          


Leu Gly Glu Leu Leu Ala Gly His Gly Arg Tyr Ala Glu Ala Leu Glu 
        35                  40                  45              


Gln His Trp Gln Glu Leu Gln Leu Arg Glu Arg Ala Asp Asp Pro Leu 
    50                  55                  60                  


Gly Cys Ala Val Ala His Arg Lys Ile Gly Glu Arg Leu Ala Glu Met 
65                  70                  75                  80  


Glu Asp Tyr Pro Ala Ala Leu Gln His Gln His Gln Tyr Leu Glu Leu 
                85                  90                  95      


Ala His Ser Leu Arg Asn His Thr Glu Leu Gln Arg Ala Trp Ala Thr 
            100                 105                 110         


Ile Gly Arg Thr His Leu Asp Ile Tyr Asp His Cys Gln Ser Arg Asp 
        115                 120                 125             


Ala Leu Leu Gln Ala Gln Ala Ala Phe Glu Lys Ser Leu Ala Ile Val 
    130                 135                 140                 


Asp Glu Glu Leu Glu Gly Thr Leu Ala Gln Gly Glu Leu Asn Glu Met 
145                 150                 155                 160 


Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln 
                165                 170                 175     


Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala 
            180                 185                 190         


Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu 
        195                 200                 205             


Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg Cys 
    210                 215                 220                 


Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe Met 
225                 230                 235                 240 


Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Leu Gln Asp Leu Gly 
                245                 250                 255     


Asp Phe Leu Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly 
            260                 265                 270         


Ser Gln Lys Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His 
        275                 280                 285             


Val Leu Ala Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Asp Pro Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu 
305                 310                 315                 320 


Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys 
                325                 330                 335     


Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala 
            340                 345                 350         


Ile Ile His Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His 
        355                 360                 365             


His Gly Ala Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly 
    370                 375                 380                 


Asn Val Leu Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg 
385                 390                 395                 400 


Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys 
                405                 410                 415     


Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln 
            420                 425                 430         


Val Leu Gln His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu 
        435                 440                 445             


Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp 
    450                 455                 460                 


Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser 
465                 470                 475                 480 


Glu Ala Leu Glu Ala Gly Glu Val Glu Leu Ser Glu Gly Glu Asp Asp 
                485                 490                 495     


Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly 
            500                 505                 510         


His Leu Gly Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met 
        515                 520                 525             


Gly Glu Thr Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg 
    530                 535                 540                 


Val Gln Asp Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Asp Tyr 
545                 550                 555                 560 


Cys Gly Trp Thr Pro Leu His Glu Ala Cys Asn Tyr Gly His Leu Glu 
                565                 570                 575     


Ile Val Arg Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly 
            580                 585                 590         


Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu His Asp Ala Leu Asn Cys 
        595                 600                 605             


Gly His Phe Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val 
    610                 615                 620                 


Thr Leu Arg Thr Arg Lys Gly Leu Ser Pro Leu Glu Thr Leu Gln Gln 
625                 630                 635                 640 


Trp Val Lys Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys 
                645                 650                 655     


Ala Arg Ala Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Asp 
            660                 665                 670         


Pro His Ser Ser Gln Ala Phe His Thr Pro Ser Ser Leu Leu Phe Asp 
        675                 680                 685             


Pro Glu Thr Ser Pro Pro Leu Ser Pro Cys Pro Glu Pro Pro Ser Asn 
    690                 695                 700                 


Ser Thr Arg Leu Pro Glu Ala Ser Gln Ala His Val Arg Val Ser Pro 
705                 710                 715                 720 


Gly Gln Ala Ala Pro Ala Met Ala Arg Pro Arg Arg Ser Arg His Gly 
                725                 730                 735     


Pro Ala Ser Ser Ser Ser Ser Ser Glu Gly Glu Asp Ser Ala Gly Pro 
            740                 745                 750         


Ala Arg Pro Ser Gln Lys Arg Pro Arg Cys Ser Ala Thr Ala Gln Arg 
        755                 760                 765             


Val Ala Ala Trp Thr Pro Gly Pro Ala Ser Asn Arg Glu Ala Ala Thr 
    770                 775                 780                 


Ala Ser Thr Ser Arg Ala Ala Tyr Gln Ala Ala Ile Arg Gly Val Gly 
785                 790                 795                 800 


Ser Ala Gln Ser Arg Leu Gly Pro Gly Pro Pro Arg Gly His Ser Lys 
                805                 810                 815     


Ala Leu Ala Pro Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala 
            820                 825                 830         


Gly Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro 
        835                 840                 845             


Arg Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly 
    850                 855                 860                 


Ser Asp Ser Glu Glu Ser Arg Pro Arg Ala Arg Ala Lys Gln Val Arg 
865                 870                 875                 880 


Leu Thr Cys Met Gln Ser Cys Ser Ala Pro Val Asn Ala Gly Pro Ser 
                885                 890                 895     


Ser Leu Ala Ser Glu Pro Pro Gly Ser Pro Ser Thr Pro Arg Val Ser 
            900                 905                 910         


Glu Pro Ser Gly Asp Ser Ser Ala Ala Gly Gln Pro Leu Gly Pro Ala 
        915                 920                 925             


Pro Pro Pro Pro Ile Arg Val Arg Val Gln Val Gln Asp His Leu Phe 
    930                 935                 940                 


Leu Ile Pro Val Pro His Ser Ser Asp Thr His Ser Val Ala Trp Leu 
945                 950                 955                 960 


Ala Glu Gln Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro 
                965                 970                 975     


Arg Leu Thr Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu 
            980                 985                 990         


Ile Pro Asp Val Leu Gln Ser Asn  Asp Glu Val Leu Ala  Glu Val Thr 
        995                 1000                 1005             


Ser Trp  Asp Leu Pro Pro Leu  Thr Asp Arg Tyr Arg  Arg Ala Cys 
    1010                 1015                 1020             


Gln Ser  Leu Gly Gln Gly Glu  His Gln Gln Val Leu  Gln Ala Val 
    1025                 1030                 1035             


Glu Leu  Gln Gly Leu Gly Leu  Ser Phe Ser Ala Cys  Ser Leu Ala 
    1040                 1045                 1050             


Leu Asp  Gln Ala Gln Leu Thr  Pro Leu Leu Arg Ala  Leu Lys Leu 
    1055                 1060                 1065             


His Thr  Ala Leu Arg Glu Leu  Arg Leu Ala Gly Asn  Arg Leu Gly 
    1070                 1075                 1080             


Asp Lys  Cys Val Ala Glu Leu  Val Ala Ala Leu Gly  Thr Met Pro 
    1085                 1090                 1095             


Ser Leu  Ala Leu Leu Asp Leu  Ser Ser Asn His Leu  Gly Pro Glu 
    1100                 1105                 1110             


Gly Leu  Arg Gln Leu Ala Met  Gly Leu Pro Gly Gln  Ala Thr Leu 
    1115                 1120                 1125             


Gln Ser  Leu Glu Glu Leu Asp  Leu Ser Met Asn Pro  Leu Gly Asp 
    1130                 1135                 1140             


Gly Cys  Gly Gln Ser Leu Ala  Ser Leu Leu His Ala  Cys Pro Leu 
    1145                 1150                 1155             


Leu Ser  Thr Leu Arg Leu Gln  Ala Cys Gly Phe Gly  Pro Ser Phe 
    1160                 1165                 1170             


Phe Leu  Ser His Gln Thr Ala  Leu Gly Ser Ala Phe  Gln Asp Ala 
    1175                 1180                 1185             


Glu His  Leu Lys Thr Leu Ser  Leu Ser Tyr Asn Ala  Leu Gly Ala 
    1190                 1195                 1200             


Pro Ala  Leu Ala Arg Thr Leu  Gln Ser Leu Pro Ala  Gly Thr Leu 
    1205                 1210                 1215             


Leu His  Leu Glu Leu Ser Ser  Val Ala Ala Gly Lys  Gly Asp Ser 
    1220                 1225                 1230             


Asp Leu  Met Glu Pro Val Phe  Arg Tyr Leu Ala Lys  Glu Gly Cys 
    1235                 1240                 1245             


Ala Leu  Ala His Leu Thr Leu  Ser Ala Asn His Leu  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Arg Asp Leu Cys Arg  Cys Leu Ser Leu Cys  Pro Ser Leu 
    1265                 1270                 1275             


Ile Ser  Leu Asp Leu Ser Ala  Asn Pro Glu Ile Ser  Cys Ala Ser 
    1280                 1285                 1290             


Leu Glu  Glu Leu Leu Ser Thr  Leu Gln Lys Arg Pro  Gln Gly Leu 
    1295                 1300                 1305             


Ser Phe  Leu Gly Leu Ser Gly  Cys Ala Val Gln Gly  Pro Leu Gly 
    1310                 1315                 1320             


Leu Gly  Leu Trp Asp Lys Ile  Ala Ala Gln Leu Arg  Glu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Ser Arg Arg Leu Cys  Ala Glu Asp Arg Asp  Ala Leu Arg 
    1340                 1345                 1350             


Gln Leu  Gln Pro Ser Arg Pro  Gly Pro Gly Glu Cys  Thr Leu Asp 
    1355                 1360                 1365             


His Gly  Ser Lys Leu Phe Phe  Arg Arg Leu 
    1370                 1375             


<210>  17
<211>  1378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant protein

<400>  17

Met Ser Leu Glu Arg Glu Leu Arg Gln Leu Ser Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Gln Arg Ala Gly Gln Arg Arg Glu Glu Ala Ala Leu Cys His Gln 
            20                  25                  30          


Leu Gly Glu Leu Leu Ala Gly His Gly Arg Tyr Ala Glu Ala Leu Glu 
        35                  40                  45              


Gln His Trp Gln Glu Leu Gln Leu Arg Glu Arg Ala Asp Asp Pro Leu 
    50                  55                  60                  


Gly Cys Ala Val Ala His Arg Lys Ile Gly Glu Arg Leu Ala Glu Met 
65                  70                  75                  80  


Glu Asp Tyr Pro Ala Ala Leu Gln His Gln His Gln Tyr Leu Glu Leu 
                85                  90                  95      


Ala His Ser Leu Arg Asn His Thr Glu Leu Gln Arg Ala Trp Ala Thr 
            100                 105                 110         


Ile Gly Arg Thr His Leu Asp Ile Tyr Asp His Cys Gln Ser Arg Asp 
        115                 120                 125             


Ala Leu Leu Gln Ala Gln Ala Ala Phe Glu Lys Ser Leu Ala Ile Val 
    130                 135                 140                 


Asp Glu Glu Leu Glu Gly Thr Leu Ala Gln Gly Glu Leu Asn Glu Met 
145                 150                 155                 160 


Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln 
                165                 170                 175     


Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala 
            180                 185                 190         


Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu 
        195                 200                 205             


Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg Cys 
    210                 215                 220                 


Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe Met 
225                 230                 235                 240 


Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Leu Gln Asp Leu Gly 
                245                 250                 255     


Asp Phe Leu Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly 
            260                 265                 270         


Ser Gln Lys Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His 
        275                 280                 285             


Val Leu Ala Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Asp Pro Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu 
305                 310                 315                 320 


Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys 
                325                 330                 335     


Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala 
            340                 345                 350         


Ile Ile His Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His 
        355                 360                 365             


His Gly Ala Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly 
    370                 375                 380                 


Asn Val Leu Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg 
385                 390                 395                 400 


Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys 
                405                 410                 415     


Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln 
            420                 425                 430         


Val Leu Gln His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu 
        435                 440                 445             


Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp 
    450                 455                 460                 


Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser 
465                 470                 475                 480 


Glu Ala Leu Glu Ala Gly Glu Val Glu Leu Ser Glu Gly Glu Asp Asp 
                485                 490                 495     


Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly 
            500                 505                 510         


His Leu Gly Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met 
        515                 520                 525             


Gly Ala Thr Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg 
    530                 535                 540                 


Val Gln Asp Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Asp Tyr 
545                 550                 555                 560 


Cys Gly Trp Thr Pro Leu His Glu Ala Cys Asn Tyr Gly His Leu Glu 
                565                 570                 575     


Ile Val Arg Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly 
            580                 585                 590         


Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu His Asp Ala Leu Asn Cys 
        595                 600                 605             


Gly His Phe Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val 
    610                 615                 620                 


Thr Leu Arg Thr Arg Lys Gly Leu Ser Pro Leu Glu Thr Leu Gln Gln 
625                 630                 635                 640 


Trp Val Lys Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys 
                645                 650                 655     


Ala Arg Ala Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Asp 
            660                 665                 670         


Pro His Ser Ser Gln Ala Phe His Thr Pro Ser Ser Leu Leu Phe Asp 
        675                 680                 685             


Pro Glu Thr Ser Pro Pro Leu Ser Pro Cys Pro Glu Pro Pro Ser Asn 
    690                 695                 700                 


Ser Thr Arg Leu Pro Glu Ala Ser Gln Ala His Val Arg Val Ser Pro 
705                 710                 715                 720 


Gly Gln Ala Ala Pro Ala Met Ala Arg Pro Arg Arg Ser Arg His Gly 
                725                 730                 735     


Pro Ala Ser Ser Ser Ser Ser Ser Glu Gly Glu Asp Ser Ala Gly Pro 
            740                 745                 750         


Ala Arg Pro Ser Gln Lys Arg Pro Arg Cys Ser Ala Thr Ala Gln Arg 
        755                 760                 765             


Val Ala Ala Trp Thr Pro Gly Pro Ala Ser Asn Arg Glu Ala Ala Thr 
    770                 775                 780                 


Ala Ser Thr Ser Arg Ala Ala Tyr Gln Ala Ala Ile Arg Gly Val Gly 
785                 790                 795                 800 


Ser Ala Gln Ser Arg Leu Gly Pro Gly Pro Pro Arg Gly His Ser Lys 
                805                 810                 815     


Ala Leu Ala Pro Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala 
            820                 825                 830         


Gly Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro 
        835                 840                 845             


Arg Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly 
    850                 855                 860                 


Ser Asp Ser Glu Glu Ser Arg Pro Arg Ala Arg Ala Lys Gln Val Arg 
865                 870                 875                 880 


Leu Thr Cys Met Gln Ser Cys Ser Ala Pro Val Asn Ala Gly Pro Ser 
                885                 890                 895     


Ser Leu Ala Ser Glu Pro Pro Gly Ser Pro Ser Thr Pro Arg Val Ser 
            900                 905                 910         


Glu Pro Ser Gly Asp Ser Ser Ala Ala Gly Gln Pro Leu Gly Pro Ala 
        915                 920                 925             


Pro Pro Pro Pro Ile Arg Val Arg Val Gln Val Gln Asp His Leu Phe 
    930                 935                 940                 


Leu Ile Pro Val Pro His Ser Ser Asp Thr His Ser Val Ala Trp Leu 
945                 950                 955                 960 


Ala Glu Gln Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro 
                965                 970                 975     


Arg Leu Thr Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu 
            980                 985                 990         


Ile Pro Asp Val Leu Gln Ser Asn  Asp Glu Val Leu Ala  Glu Val Thr 
        995                 1000                 1005             


Ser Trp  Asp Leu Pro Pro Leu  Thr Asp Arg Tyr Arg  Arg Ala Cys 
    1010                 1015                 1020             


Gln Ser  Leu Gly Gln Gly Glu  His Gln Gln Val Leu  Gln Ala Val 
    1025                 1030                 1035             


Glu Leu  Gln Gly Leu Gly Leu  Ser Phe Ser Ala Cys  Ser Leu Ala 
    1040                 1045                 1050             


Leu Asp  Gln Ala Gln Leu Thr  Pro Leu Leu Arg Ala  Leu Lys Leu 
    1055                 1060                 1065             


His Thr  Ala Leu Arg Glu Leu  Arg Leu Ala Gly Asn  Arg Leu Gly 
    1070                 1075                 1080             


Asp Lys  Cys Val Ala Glu Leu  Val Ala Ala Leu Gly  Thr Met Pro 
    1085                 1090                 1095             


Ser Leu  Ala Leu Leu Asp Leu  Ser Ser Asn His Leu  Gly Pro Glu 
    1100                 1105                 1110             


Gly Leu  Arg Gln Leu Ala Met  Gly Leu Pro Gly Gln  Ala Thr Leu 
    1115                 1120                 1125             


Gln Ser  Leu Glu Glu Leu Asp  Leu Ser Met Asn Pro  Leu Gly Asp 
    1130                 1135                 1140             


Gly Cys  Gly Gln Ser Leu Ala  Ser Leu Leu His Ala  Cys Pro Leu 
    1145                 1150                 1155             


Leu Ser  Thr Leu Arg Leu Gln  Ala Cys Gly Phe Gly  Pro Ser Phe 
    1160                 1165                 1170             


Phe Leu  Ser His Gln Thr Ala  Leu Gly Ser Ala Phe  Gln Asp Ala 
    1175                 1180                 1185             


Glu His  Leu Lys Thr Leu Ser  Leu Ser Tyr Asn Ala  Leu Gly Ala 
    1190                 1195                 1200             


Pro Ala  Leu Ala Arg Thr Leu  Gln Ser Leu Pro Ala  Gly Thr Leu 
    1205                 1210                 1215             


Leu His  Leu Glu Leu Ser Ser  Val Ala Ala Gly Lys  Gly Asp Ser 
    1220                 1225                 1230             


Asp Leu  Met Glu Pro Val Phe  Arg Tyr Leu Ala Lys  Glu Gly Cys 
    1235                 1240                 1245             


Ala Leu  Ala His Leu Thr Leu  Ser Ala Asn His Leu  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Arg Asp Leu Cys Arg  Cys Leu Ser Leu Cys  Pro Ser Leu 
    1265                 1270                 1275             


Ile Ser  Leu Asp Leu Ser Ala  Asn Pro Glu Ile Ser  Cys Ala Ser 
    1280                 1285                 1290             


Leu Glu  Glu Leu Leu Ser Thr  Leu Gln Lys Arg Pro  Gln Gly Leu 
    1295                 1300                 1305             


Ser Phe  Leu Gly Leu Ser Gly  Cys Ala Val Gln Gly  Pro Leu Gly 
    1310                 1315                 1320             


Leu Gly  Leu Trp Asp Lys Ile  Ala Ala Gln Leu Arg  Glu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Ser Arg Arg Leu Cys  Ala Glu Asp Arg Asp  Ala Leu Arg 
    1340                 1345                 1350             


Gln Leu  Gln Pro Ser Arg Pro  Gly Pro Gly Glu Cys  Thr Leu Asp 
    1355                 1360                 1365             


His Gly  Ser Lys Leu Phe Phe  Arg Arg Leu 
    1370                 1375             


<210>  18
<211>  1378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant protein

<400>  18

Met Ser Leu Glu Arg Glu Leu Arg Gln Leu Ser Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Gln Arg Ala Gly Gln Arg Arg Glu Glu Ala Ala Leu Cys His Gln 
            20                  25                  30          


Leu Gly Glu Leu Leu Ala Gly His Gly Arg Tyr Ala Glu Ala Leu Glu 
        35                  40                  45              


Gln His Trp Gln Glu Leu Gln Leu Arg Glu Arg Ala Asp Asp Pro Leu 
    50                  55                  60                  


Gly Cys Ala Val Ala His Arg Lys Ile Gly Glu Arg Leu Ala Glu Met 
65                  70                  75                  80  


Glu Asp Tyr Pro Ala Ala Leu Gln His Gln His Gln Tyr Leu Glu Leu 
                85                  90                  95      


Ala His Ser Leu Arg Asn His Thr Glu Leu Gln Arg Ala Trp Ala Thr 
            100                 105                 110         


Ile Gly Arg Thr His Leu Asp Ile Tyr Asp His Cys Gln Ser Arg Asp 
        115                 120                 125             


Ala Leu Leu Gln Ala Gln Ala Ala Phe Glu Lys Ser Leu Ala Ile Val 
    130                 135                 140                 


Asp Glu Glu Leu Glu Gly Thr Leu Ala Gln Gly Glu Leu Asn Glu Met 
145                 150                 155                 160 


Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln 
                165                 170                 175     


Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala 
            180                 185                 190         


Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu 
        195                 200                 205             


Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg Cys 
    210                 215                 220                 


Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe Met 
225                 230                 235                 240 


Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Leu Gln Asp Leu Gly 
                245                 250                 255     


Asp Phe Leu Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly 
            260                 265                 270         


Ser Gln Lys Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His 
        275                 280                 285             


Val Leu Ala Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Asp Pro Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu 
305                 310                 315                 320 


Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys 
                325                 330                 335     


Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala 
            340                 345                 350         


Ile Ile His Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His 
        355                 360                 365             


His Gly Ala Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly 
    370                 375                 380                 


Asn Val Leu Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg 
385                 390                 395                 400 


Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys 
                405                 410                 415     


Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln 
            420                 425                 430         


Val Leu Gln His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu 
        435                 440                 445             


Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp 
    450                 455                 460                 


Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser 
465                 470                 475                 480 


Glu Ala Leu Glu Ala Gly Glu Val Glu Leu Ser Glu Gly Glu Asp Asp 
                485                 490                 495     


Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly 
            500                 505                 510         


His Leu Gly Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met 
        515                 520                 525             


Gly Glu Thr Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg 
    530                 535                 540                 


Val Gln Asp Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Ala Tyr 
545                 550                 555                 560 


Cys Gly Trp Thr Pro Leu His Glu Ala Cys Asn Tyr Gly His Leu Glu 
                565                 570                 575     


Ile Val Arg Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly 
            580                 585                 590         


Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu His Asp Ala Leu Asn Cys 
        595                 600                 605             


Gly His Phe Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val 
    610                 615                 620                 


Thr Leu Arg Thr Arg Lys Gly Leu Ser Pro Leu Glu Thr Leu Gln Gln 
625                 630                 635                 640 


Trp Val Lys Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys 
                645                 650                 655     


Ala Arg Ala Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Asp 
            660                 665                 670         


Pro His Ser Ser Gln Ala Phe His Thr Pro Ser Ser Leu Leu Phe Asp 
        675                 680                 685             


Pro Glu Thr Ser Pro Pro Leu Ser Pro Cys Pro Glu Pro Pro Ser Asn 
    690                 695                 700                 


Ser Thr Arg Leu Pro Glu Ala Ser Gln Ala His Val Arg Val Ser Pro 
705                 710                 715                 720 


Gly Gln Ala Ala Pro Ala Met Ala Arg Pro Arg Arg Ser Arg His Gly 
                725                 730                 735     


Pro Ala Ser Ser Ser Ser Ser Ser Glu Gly Glu Asp Ser Ala Gly Pro 
            740                 745                 750         


Ala Arg Pro Ser Gln Lys Arg Pro Arg Cys Ser Ala Thr Ala Gln Arg 
        755                 760                 765             


Val Ala Ala Trp Thr Pro Gly Pro Ala Ser Asn Arg Glu Ala Ala Thr 
    770                 775                 780                 


Ala Ser Thr Ser Arg Ala Ala Tyr Gln Ala Ala Ile Arg Gly Val Gly 
785                 790                 795                 800 


Ser Ala Gln Ser Arg Leu Gly Pro Gly Pro Pro Arg Gly His Ser Lys 
                805                 810                 815     


Ala Leu Ala Pro Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala 
            820                 825                 830         


Gly Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro 
        835                 840                 845             


Arg Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly 
    850                 855                 860                 


Ser Asp Ser Glu Glu Ser Arg Pro Arg Ala Arg Ala Lys Gln Val Arg 
865                 870                 875                 880 


Leu Thr Cys Met Gln Ser Cys Ser Ala Pro Val Asn Ala Gly Pro Ser 
                885                 890                 895     


Ser Leu Ala Ser Glu Pro Pro Gly Ser Pro Ser Thr Pro Arg Val Ser 
            900                 905                 910         


Glu Pro Ser Gly Asp Ser Ser Ala Ala Gly Gln Pro Leu Gly Pro Ala 
        915                 920                 925             


Pro Pro Pro Pro Ile Arg Val Arg Val Gln Val Gln Asp His Leu Phe 
    930                 935                 940                 


Leu Ile Pro Val Pro His Ser Ser Asp Thr His Ser Val Ala Trp Leu 
945                 950                 955                 960 


Ala Glu Gln Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro 
                965                 970                 975     


Arg Leu Thr Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu 
            980                 985                 990         


Ile Pro Asp Val Leu Gln Ser Asn  Asp Glu Val Leu Ala  Glu Val Thr 
        995                 1000                 1005             


Ser Trp  Asp Leu Pro Pro Leu  Thr Asp Arg Tyr Arg  Arg Ala Cys 
    1010                 1015                 1020             


Gln Ser  Leu Gly Gln Gly Glu  His Gln Gln Val Leu  Gln Ala Val 
    1025                 1030                 1035             


Glu Leu  Gln Gly Leu Gly Leu  Ser Phe Ser Ala Cys  Ser Leu Ala 
    1040                 1045                 1050             


Leu Asp  Gln Ala Gln Leu Thr  Pro Leu Leu Arg Ala  Leu Lys Leu 
    1055                 1060                 1065             


His Thr  Ala Leu Arg Glu Leu  Arg Leu Ala Gly Asn  Arg Leu Gly 
    1070                 1075                 1080             


Asp Lys  Cys Val Ala Glu Leu  Val Ala Ala Leu Gly  Thr Met Pro 
    1085                 1090                 1095             


Ser Leu  Ala Leu Leu Asp Leu  Ser Ser Asn His Leu  Gly Pro Glu 
    1100                 1105                 1110             


Gly Leu  Arg Gln Leu Ala Met  Gly Leu Pro Gly Gln  Ala Thr Leu 
    1115                 1120                 1125             


Gln Ser  Leu Glu Glu Leu Asp  Leu Ser Met Asn Pro  Leu Gly Asp 
    1130                 1135                 1140             


Gly Cys  Gly Gln Ser Leu Ala  Ser Leu Leu His Ala  Cys Pro Leu 
    1145                 1150                 1155             


Leu Ser  Thr Leu Arg Leu Gln  Ala Cys Gly Phe Gly  Pro Ser Phe 
    1160                 1165                 1170             


Phe Leu  Ser His Gln Thr Ala  Leu Gly Ser Ala Phe  Gln Asp Ala 
    1175                 1180                 1185             


Glu His  Leu Lys Thr Leu Ser  Leu Ser Tyr Asn Ala  Leu Gly Ala 
    1190                 1195                 1200             


Pro Ala  Leu Ala Arg Thr Leu  Gln Ser Leu Pro Ala  Gly Thr Leu 
    1205                 1210                 1215             


Leu His  Leu Glu Leu Ser Ser  Val Ala Ala Gly Lys  Gly Asp Ser 
    1220                 1225                 1230             


Asp Leu  Met Glu Pro Val Phe  Arg Tyr Leu Ala Lys  Glu Gly Cys 
    1235                 1240                 1245             


Ala Leu  Ala His Leu Thr Leu  Ser Ala Asn His Leu  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Arg Asp Leu Cys Arg  Cys Leu Ser Leu Cys  Pro Ser Leu 
    1265                 1270                 1275             


Ile Ser  Leu Asp Leu Ser Ala  Asn Pro Glu Ile Ser  Cys Ala Ser 
    1280                 1285                 1290             


Leu Glu  Glu Leu Leu Ser Thr  Leu Gln Lys Arg Pro  Gln Gly Leu 
    1295                 1300                 1305             


Ser Phe  Leu Gly Leu Ser Gly  Cys Ala Val Gln Gly  Pro Leu Gly 
    1310                 1315                 1320             


Leu Gly  Leu Trp Asp Lys Ile  Ala Ala Gln Leu Arg  Glu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Ser Arg Arg Leu Cys  Ala Glu Asp Arg Asp  Ala Leu Arg 
    1340                 1345                 1350             


Gln Leu  Gln Pro Ser Arg Pro  Gly Pro Gly Glu Cys  Thr Leu Asp 
    1355                 1360                 1365             


His Gly  Ser Lys Leu Phe Phe  Arg Arg Leu 
    1370                 1375             


<210>  19
<211>  1378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant protein

<400>  19

Met Ser Leu Glu Arg Glu Leu Arg Gln Leu Ser Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Gln Arg Ala Gly Gln Arg Arg Glu Glu Ala Ala Leu Cys His Gln 
            20                  25                  30          


Leu Gly Glu Leu Leu Ala Gly His Gly Arg Tyr Ala Glu Ala Leu Glu 
        35                  40                  45              


Gln His Trp Gln Glu Leu Gln Leu Arg Glu Arg Ala Asp Asp Pro Leu 
    50                  55                  60                  


Gly Cys Ala Val Ala His Arg Lys Ile Gly Glu Arg Leu Ala Glu Met 
65                  70                  75                  80  


Glu Asp Tyr Pro Ala Ala Leu Gln His Gln His Gln Tyr Leu Glu Leu 
                85                  90                  95      


Ala His Ser Leu Arg Asn His Thr Glu Leu Gln Arg Ala Trp Ala Thr 
            100                 105                 110         


Ile Gly Arg Thr His Leu Asp Ile Tyr Asp His Cys Gln Ser Arg Asp 
        115                 120                 125             


Ala Leu Leu Gln Ala Gln Ala Ala Phe Glu Lys Ser Leu Ala Ile Val 
    130                 135                 140                 


Asp Glu Glu Leu Glu Gly Thr Leu Ala Gln Gly Glu Leu Asn Glu Met 
145                 150                 155                 160 


Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln 
                165                 170                 175     


Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala 
            180                 185                 190         


Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu 
        195                 200                 205             


Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg Cys 
    210                 215                 220                 


Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe Met 
225                 230                 235                 240 


Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Leu Gln Asp Leu Gly 
                245                 250                 255     


Asp Phe Leu Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly 
            260                 265                 270         


Ser Gln Lys Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His 
        275                 280                 285             


Val Leu Ala Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Asp Pro Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu 
305                 310                 315                 320 


Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys 
                325                 330                 335     


Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala 
            340                 345                 350         


Ile Ile His Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His 
        355                 360                 365             


His Gly Ala Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly 
    370                 375                 380                 


Asn Val Leu Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg 
385                 390                 395                 400 


Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys 
                405                 410                 415     


Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln 
            420                 425                 430         


Val Leu Gln His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu 
        435                 440                 445             


Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp 
    450                 455                 460                 


Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser 
465                 470                 475                 480 


Glu Ala Leu Glu Ala Gly Glu Val Glu Leu Ser Glu Gly Glu Asp Asp 
                485                 490                 495     


Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly 
            500                 505                 510         


His Leu Gly Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met 
        515                 520                 525             


Gly Glu Thr Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg 
    530                 535                 540                 


Val Gln Asp Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Asp Tyr 
545                 550                 555                 560 


Cys Gly Ala Thr Pro Leu His Glu Ala Cys Asn Tyr Gly His Leu Glu 
                565                 570                 575     


Ile Val Arg Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly 
            580                 585                 590         


Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu His Asp Ala Leu Asn Cys 
        595                 600                 605             


Gly His Phe Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val 
    610                 615                 620                 


Thr Leu Arg Thr Arg Lys Gly Leu Ser Pro Leu Glu Thr Leu Gln Gln 
625                 630                 635                 640 


Trp Val Lys Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys 
                645                 650                 655     


Ala Arg Ala Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Asp 
            660                 665                 670         


Pro His Ser Ser Gln Ala Phe His Thr Pro Ser Ser Leu Leu Phe Asp 
        675                 680                 685             


Pro Glu Thr Ser Pro Pro Leu Ser Pro Cys Pro Glu Pro Pro Ser Asn 
    690                 695                 700                 


Ser Thr Arg Leu Pro Glu Ala Ser Gln Ala His Val Arg Val Ser Pro 
705                 710                 715                 720 


Gly Gln Ala Ala Pro Ala Met Ala Arg Pro Arg Arg Ser Arg His Gly 
                725                 730                 735     


Pro Ala Ser Ser Ser Ser Ser Ser Glu Gly Glu Asp Ser Ala Gly Pro 
            740                 745                 750         


Ala Arg Pro Ser Gln Lys Arg Pro Arg Cys Ser Ala Thr Ala Gln Arg 
        755                 760                 765             


Val Ala Ala Trp Thr Pro Gly Pro Ala Ser Asn Arg Glu Ala Ala Thr 
    770                 775                 780                 


Ala Ser Thr Ser Arg Ala Ala Tyr Gln Ala Ala Ile Arg Gly Val Gly 
785                 790                 795                 800 


Ser Ala Gln Ser Arg Leu Gly Pro Gly Pro Pro Arg Gly His Ser Lys 
                805                 810                 815     


Ala Leu Ala Pro Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala 
            820                 825                 830         


Gly Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro 
        835                 840                 845             


Arg Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly 
    850                 855                 860                 


Ser Asp Ser Glu Glu Ser Arg Pro Arg Ala Arg Ala Lys Gln Val Arg 
865                 870                 875                 880 


Leu Thr Cys Met Gln Ser Cys Ser Ala Pro Val Asn Ala Gly Pro Ser 
                885                 890                 895     


Ser Leu Ala Ser Glu Pro Pro Gly Ser Pro Ser Thr Pro Arg Val Ser 
            900                 905                 910         


Glu Pro Ser Gly Asp Ser Ser Ala Ala Gly Gln Pro Leu Gly Pro Ala 
        915                 920                 925             


Pro Pro Pro Pro Ile Arg Val Arg Val Gln Val Gln Asp His Leu Phe 
    930                 935                 940                 


Leu Ile Pro Val Pro His Ser Ser Asp Thr His Ser Val Ala Trp Leu 
945                 950                 955                 960 


Ala Glu Gln Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro 
                965                 970                 975     


Arg Leu Thr Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu 
            980                 985                 990         


Ile Pro Asp Val Leu Gln Ser Asn  Asp Glu Val Leu Ala  Glu Val Thr 
        995                 1000                 1005             


Ser Trp  Asp Leu Pro Pro Leu  Thr Asp Arg Tyr Arg  Arg Ala Cys 
    1010                 1015                 1020             


Gln Ser  Leu Gly Gln Gly Glu  His Gln Gln Val Leu  Gln Ala Val 
    1025                 1030                 1035             


Glu Leu  Gln Gly Leu Gly Leu  Ser Phe Ser Ala Cys  Ser Leu Ala 
    1040                 1045                 1050             


Leu Asp  Gln Ala Gln Leu Thr  Pro Leu Leu Arg Ala  Leu Lys Leu 
    1055                 1060                 1065             


His Thr  Ala Leu Arg Glu Leu  Arg Leu Ala Gly Asn  Arg Leu Gly 
    1070                 1075                 1080             


Asp Lys  Cys Val Ala Glu Leu  Val Ala Ala Leu Gly  Thr Met Pro 
    1085                 1090                 1095             


Ser Leu  Ala Leu Leu Asp Leu  Ser Ser Asn His Leu  Gly Pro Glu 
    1100                 1105                 1110             


Gly Leu  Arg Gln Leu Ala Met  Gly Leu Pro Gly Gln  Ala Thr Leu 
    1115                 1120                 1125             


Gln Ser  Leu Glu Glu Leu Asp  Leu Ser Met Asn Pro  Leu Gly Asp 
    1130                 1135                 1140             


Gly Cys  Gly Gln Ser Leu Ala  Ser Leu Leu His Ala  Cys Pro Leu 
    1145                 1150                 1155             


Leu Ser  Thr Leu Arg Leu Gln  Ala Cys Gly Phe Gly  Pro Ser Phe 
    1160                 1165                 1170             


Phe Leu  Ser His Gln Thr Ala  Leu Gly Ser Ala Phe  Gln Asp Ala 
    1175                 1180                 1185             


Glu His  Leu Lys Thr Leu Ser  Leu Ser Tyr Asn Ala  Leu Gly Ala 
    1190                 1195                 1200             


Pro Ala  Leu Ala Arg Thr Leu  Gln Ser Leu Pro Ala  Gly Thr Leu 
    1205                 1210                 1215             


Leu His  Leu Glu Leu Ser Ser  Val Ala Ala Gly Lys  Gly Asp Ser 
    1220                 1225                 1230             


Asp Leu  Met Glu Pro Val Phe  Arg Tyr Leu Ala Lys  Glu Gly Cys 
    1235                 1240                 1245             


Ala Leu  Ala His Leu Thr Leu  Ser Ala Asn His Leu  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Arg Asp Leu Cys Arg  Cys Leu Ser Leu Cys  Pro Ser Leu 
    1265                 1270                 1275             


Ile Ser  Leu Asp Leu Ser Ala  Asn Pro Glu Ile Ser  Cys Ala Ser 
    1280                 1285                 1290             


Leu Glu  Glu Leu Leu Ser Thr  Leu Gln Lys Arg Pro  Gln Gly Leu 
    1295                 1300                 1305             


Ser Phe  Leu Gly Leu Ser Gly  Cys Ala Val Gln Gly  Pro Leu Gly 
    1310                 1315                 1320             


Leu Gly  Leu Trp Asp Lys Ile  Ala Ala Gln Leu Arg  Glu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Ser Arg Arg Leu Cys  Ala Glu Asp Arg Asp  Ala Leu Arg 
    1340                 1345                 1350             


Gln Leu  Gln Pro Ser Arg Pro  Gly Pro Gly Glu Cys  Thr Leu Asp 
    1355                 1360                 1365             


His Gly  Ser Lys Leu Phe Phe  Arg Arg Leu 
    1370                 1375             


<210>  20
<211>  1378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant protein

<400>  20

Met Ser Leu Glu Arg Glu Leu Arg Gln Leu Ser Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Gln Arg Ala Gly Gln Arg Arg Glu Glu Ala Ala Leu Cys His Gln 
            20                  25                  30          


Leu Gly Glu Leu Leu Ala Gly His Gly Arg Tyr Ala Glu Ala Leu Glu 
        35                  40                  45              


Gln His Trp Gln Glu Leu Gln Leu Arg Glu Arg Ala Asp Asp Pro Leu 
    50                  55                  60                  


Gly Cys Ala Val Ala His Arg Lys Ile Gly Glu Arg Leu Ala Glu Met 
65                  70                  75                  80  


Glu Asp Tyr Pro Ala Ala Leu Gln His Gln His Gln Tyr Leu Glu Leu 
                85                  90                  95      


Ala His Ser Leu Arg Asn His Thr Glu Leu Gln Arg Ala Trp Ala Thr 
            100                 105                 110         


Ile Gly Arg Thr His Leu Asp Ile Tyr Asp His Cys Gln Ser Arg Asp 
        115                 120                 125             


Ala Leu Leu Gln Ala Gln Ala Ala Phe Glu Lys Ser Leu Ala Ile Val 
    130                 135                 140                 


Asp Glu Glu Leu Glu Gly Thr Leu Ala Gln Gly Glu Leu Asn Glu Met 
145                 150                 155                 160 


Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln 
                165                 170                 175     


Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala 
            180                 185                 190         


Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu 
        195                 200                 205             


Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg Cys 
    210                 215                 220                 


Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe Met 
225                 230                 235                 240 


Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Leu Gln Asp Leu Gly 
                245                 250                 255     


Asp Phe Leu Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly 
            260                 265                 270         


Ser Gln Lys Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His 
        275                 280                 285             


Val Leu Ala Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Asp Pro Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu 
305                 310                 315                 320 


Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys 
                325                 330                 335     


Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala 
            340                 345                 350         


Ile Ile His Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His 
        355                 360                 365             


His Gly Ala Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly 
    370                 375                 380                 


Asn Val Leu Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg 
385                 390                 395                 400 


Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys 
                405                 410                 415     


Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln 
            420                 425                 430         


Val Leu Gln His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu 
        435                 440                 445             


Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp 
    450                 455                 460                 


Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser 
465                 470                 475                 480 


Glu Ala Leu Glu Ala Gly Glu Val Glu Leu Ser Glu Gly Glu Asp Asp 
                485                 490                 495     


Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly 
            500                 505                 510         


His Leu Gly Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met 
        515                 520                 525             


Gly Glu Thr Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg 
    530                 535                 540                 


Val Gln Asp Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Asp Tyr 
545                 550                 555                 560 


Cys Gly Trp Thr Pro Leu His Ala Ala Cys Asn Tyr Gly His Leu Glu 
                565                 570                 575     


Ile Val Arg Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly 
            580                 585                 590         


Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu His Asp Ala Leu Asn Cys 
        595                 600                 605             


Gly His Phe Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val 
    610                 615                 620                 


Thr Leu Arg Thr Arg Lys Gly Leu Ser Pro Leu Glu Thr Leu Gln Gln 
625                 630                 635                 640 


Trp Val Lys Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys 
                645                 650                 655     


Ala Arg Ala Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Asp 
            660                 665                 670         


Pro His Ser Ser Gln Ala Phe His Thr Pro Ser Ser Leu Leu Phe Asp 
        675                 680                 685             


Pro Glu Thr Ser Pro Pro Leu Ser Pro Cys Pro Glu Pro Pro Ser Asn 
    690                 695                 700                 


Ser Thr Arg Leu Pro Glu Ala Ser Gln Ala His Val Arg Val Ser Pro 
705                 710                 715                 720 


Gly Gln Ala Ala Pro Ala Met Ala Arg Pro Arg Arg Ser Arg His Gly 
                725                 730                 735     


Pro Ala Ser Ser Ser Ser Ser Ser Glu Gly Glu Asp Ser Ala Gly Pro 
            740                 745                 750         


Ala Arg Pro Ser Gln Lys Arg Pro Arg Cys Ser Ala Thr Ala Gln Arg 
        755                 760                 765             


Val Ala Ala Trp Thr Pro Gly Pro Ala Ser Asn Arg Glu Ala Ala Thr 
    770                 775                 780                 


Ala Ser Thr Ser Arg Ala Ala Tyr Gln Ala Ala Ile Arg Gly Val Gly 
785                 790                 795                 800 


Ser Ala Gln Ser Arg Leu Gly Pro Gly Pro Pro Arg Gly His Ser Lys 
                805                 810                 815     


Ala Leu Ala Pro Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala 
            820                 825                 830         


Gly Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro 
        835                 840                 845             


Arg Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly 
    850                 855                 860                 


Ser Asp Ser Glu Glu Ser Arg Pro Arg Ala Arg Ala Lys Gln Val Arg 
865                 870                 875                 880 


Leu Thr Cys Met Gln Ser Cys Ser Ala Pro Val Asn Ala Gly Pro Ser 
                885                 890                 895     


Ser Leu Ala Ser Glu Pro Pro Gly Ser Pro Ser Thr Pro Arg Val Ser 
            900                 905                 910         


Glu Pro Ser Gly Asp Ser Ser Ala Ala Gly Gln Pro Leu Gly Pro Ala 
        915                 920                 925             


Pro Pro Pro Pro Ile Arg Val Arg Val Gln Val Gln Asp His Leu Phe 
    930                 935                 940                 


Leu Ile Pro Val Pro His Ser Ser Asp Thr His Ser Val Ala Trp Leu 
945                 950                 955                 960 


Ala Glu Gln Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro 
                965                 970                 975     


Arg Leu Thr Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu 
            980                 985                 990         


Ile Pro Asp Val Leu Gln Ser Asn  Asp Glu Val Leu Ala  Glu Val Thr 
        995                 1000                 1005             


Ser Trp  Asp Leu Pro Pro Leu  Thr Asp Arg Tyr Arg  Arg Ala Cys 
    1010                 1015                 1020             


Gln Ser  Leu Gly Gln Gly Glu  His Gln Gln Val Leu  Gln Ala Val 
    1025                 1030                 1035             


Glu Leu  Gln Gly Leu Gly Leu  Ser Phe Ser Ala Cys  Ser Leu Ala 
    1040                 1045                 1050             


Leu Asp  Gln Ala Gln Leu Thr  Pro Leu Leu Arg Ala  Leu Lys Leu 
    1055                 1060                 1065             


His Thr  Ala Leu Arg Glu Leu  Arg Leu Ala Gly Asn  Arg Leu Gly 
    1070                 1075                 1080             


Asp Lys  Cys Val Ala Glu Leu  Val Ala Ala Leu Gly  Thr Met Pro 
    1085                 1090                 1095             


Ser Leu  Ala Leu Leu Asp Leu  Ser Ser Asn His Leu  Gly Pro Glu 
    1100                 1105                 1110             


Gly Leu  Arg Gln Leu Ala Met  Gly Leu Pro Gly Gln  Ala Thr Leu 
    1115                 1120                 1125             


Gln Ser  Leu Glu Glu Leu Asp  Leu Ser Met Asn Pro  Leu Gly Asp 
    1130                 1135                 1140             


Gly Cys  Gly Gln Ser Leu Ala  Ser Leu Leu His Ala  Cys Pro Leu 
    1145                 1150                 1155             


Leu Ser  Thr Leu Arg Leu Gln  Ala Cys Gly Phe Gly  Pro Ser Phe 
    1160                 1165                 1170             


Phe Leu  Ser His Gln Thr Ala  Leu Gly Ser Ala Phe  Gln Asp Ala 
    1175                 1180                 1185             


Glu His  Leu Lys Thr Leu Ser  Leu Ser Tyr Asn Ala  Leu Gly Ala 
    1190                 1195                 1200             


Pro Ala  Leu Ala Arg Thr Leu  Gln Ser Leu Pro Ala  Gly Thr Leu 
    1205                 1210                 1215             


Leu His  Leu Glu Leu Ser Ser  Val Ala Ala Gly Lys  Gly Asp Ser 
    1220                 1225                 1230             


Asp Leu  Met Glu Pro Val Phe  Arg Tyr Leu Ala Lys  Glu Gly Cys 
    1235                 1240                 1245             


Ala Leu  Ala His Leu Thr Leu  Ser Ala Asn His Leu  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Arg Asp Leu Cys Arg  Cys Leu Ser Leu Cys  Pro Ser Leu 
    1265                 1270                 1275             


Ile Ser  Leu Asp Leu Ser Ala  Asn Pro Glu Ile Ser  Cys Ala Ser 
    1280                 1285                 1290             


Leu Glu  Glu Leu Leu Ser Thr  Leu Gln Lys Arg Pro  Gln Gly Leu 
    1295                 1300                 1305             


Ser Phe  Leu Gly Leu Ser Gly  Cys Ala Val Gln Gly  Pro Leu Gly 
    1310                 1315                 1320             


Leu Gly  Leu Trp Asp Lys Ile  Ala Ala Gln Leu Arg  Glu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Ser Arg Arg Leu Cys  Ala Glu Asp Arg Asp  Ala Leu Arg 
    1340                 1345                 1350             


Gln Leu  Gln Pro Ser Arg Pro  Gly Pro Gly Glu Cys  Thr Leu Asp 
    1355                 1360                 1365             


His Gly  Ser Lys Leu Phe Phe  Arg Arg Leu 
    1370                 1375             


<210>  21
<211>  1378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant protein

<400>  21

Met Ser Leu Glu Arg Glu Leu Arg Gln Leu Ser Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Gln Arg Ala Gly Gln Arg Arg Glu Glu Ala Ala Leu Cys His Gln 
            20                  25                  30          


Leu Gly Glu Leu Leu Ala Gly His Gly Arg Tyr Ala Glu Ala Leu Glu 
        35                  40                  45              


Gln His Trp Gln Glu Leu Gln Leu Arg Glu Arg Ala Asp Asp Pro Leu 
    50                  55                  60                  


Gly Cys Ala Val Ala His Arg Lys Ile Gly Glu Arg Leu Ala Glu Met 
65                  70                  75                  80  


Glu Asp Tyr Pro Ala Ala Leu Gln His Gln His Gln Tyr Leu Glu Leu 
                85                  90                  95      


Ala His Ser Leu Arg Asn His Thr Glu Leu Gln Arg Ala Trp Ala Thr 
            100                 105                 110         


Ile Gly Arg Thr His Leu Asp Ile Tyr Asp His Cys Gln Ser Arg Asp 
        115                 120                 125             


Ala Leu Leu Gln Ala Gln Ala Ala Phe Glu Lys Ser Leu Ala Ile Val 
    130                 135                 140                 


Asp Glu Glu Leu Glu Gly Thr Leu Ala Gln Gly Glu Leu Asn Glu Met 
145                 150                 155                 160 


Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln 
                165                 170                 175     


Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala 
            180                 185                 190         


Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu 
        195                 200                 205             


Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg Cys 
    210                 215                 220                 


Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe Met 
225                 230                 235                 240 


Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Leu Gln Asp Leu Gly 
                245                 250                 255     


Asp Phe Leu Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly 
            260                 265                 270         


Ser Gln Lys Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His 
        275                 280                 285             


Val Leu Ala Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Asp Pro Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu 
305                 310                 315                 320 


Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys 
                325                 330                 335     


Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala 
            340                 345                 350         


Ile Ile His Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His 
        355                 360                 365             


His Gly Ala Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly 
    370                 375                 380                 


Asn Val Leu Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg 
385                 390                 395                 400 


Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys 
                405                 410                 415     


Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln 
            420                 425                 430         


Val Leu Gln His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu 
        435                 440                 445             


Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp 
    450                 455                 460                 


Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser 
465                 470                 475                 480 


Glu Ala Leu Glu Ala Gly Glu Val Glu Leu Ser Glu Gly Glu Asp Asp 
                485                 490                 495     


Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly 
            500                 505                 510         


His Leu Gly Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met 
        515                 520                 525             


Gly Glu Thr Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg 
    530                 535                 540                 


Val Gln Asp Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Asp Tyr 
545                 550                 555                 560 


Cys Gly Trp Thr Pro Leu His Glu Ala Cys Ala Tyr Gly His Leu Glu 
                565                 570                 575     


Ile Val Arg Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly 
            580                 585                 590         


Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu His Asp Ala Leu Asn Cys 
        595                 600                 605             


Gly His Phe Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val 
    610                 615                 620                 


Thr Leu Arg Thr Arg Lys Gly Leu Ser Pro Leu Glu Thr Leu Gln Gln 
625                 630                 635                 640 


Trp Val Lys Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys 
                645                 650                 655     


Ala Arg Ala Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Asp 
            660                 665                 670         


Pro His Ser Ser Gln Ala Phe His Thr Pro Ser Ser Leu Leu Phe Asp 
        675                 680                 685             


Pro Glu Thr Ser Pro Pro Leu Ser Pro Cys Pro Glu Pro Pro Ser Asn 
    690                 695                 700                 


Ser Thr Arg Leu Pro Glu Ala Ser Gln Ala His Val Arg Val Ser Pro 
705                 710                 715                 720 


Gly Gln Ala Ala Pro Ala Met Ala Arg Pro Arg Arg Ser Arg His Gly 
                725                 730                 735     


Pro Ala Ser Ser Ser Ser Ser Ser Glu Gly Glu Asp Ser Ala Gly Pro 
            740                 745                 750         


Ala Arg Pro Ser Gln Lys Arg Pro Arg Cys Ser Ala Thr Ala Gln Arg 
        755                 760                 765             


Val Ala Ala Trp Thr Pro Gly Pro Ala Ser Asn Arg Glu Ala Ala Thr 
    770                 775                 780                 


Ala Ser Thr Ser Arg Ala Ala Tyr Gln Ala Ala Ile Arg Gly Val Gly 
785                 790                 795                 800 


Ser Ala Gln Ser Arg Leu Gly Pro Gly Pro Pro Arg Gly His Ser Lys 
                805                 810                 815     


Ala Leu Ala Pro Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala 
            820                 825                 830         


Gly Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro 
        835                 840                 845             


Arg Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly 
    850                 855                 860                 


Ser Asp Ser Glu Glu Ser Arg Pro Arg Ala Arg Ala Lys Gln Val Arg 
865                 870                 875                 880 


Leu Thr Cys Met Gln Ser Cys Ser Ala Pro Val Asn Ala Gly Pro Ser 
                885                 890                 895     


Ser Leu Ala Ser Glu Pro Pro Gly Ser Pro Ser Thr Pro Arg Val Ser 
            900                 905                 910         


Glu Pro Ser Gly Asp Ser Ser Ala Ala Gly Gln Pro Leu Gly Pro Ala 
        915                 920                 925             


Pro Pro Pro Pro Ile Arg Val Arg Val Gln Val Gln Asp His Leu Phe 
    930                 935                 940                 


Leu Ile Pro Val Pro His Ser Ser Asp Thr His Ser Val Ala Trp Leu 
945                 950                 955                 960 


Ala Glu Gln Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro 
                965                 970                 975     


Arg Leu Thr Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu 
            980                 985                 990         


Ile Pro Asp Val Leu Gln Ser Asn  Asp Glu Val Leu Ala  Glu Val Thr 
        995                 1000                 1005             


Ser Trp  Asp Leu Pro Pro Leu  Thr Asp Arg Tyr Arg  Arg Ala Cys 
    1010                 1015                 1020             


Gln Ser  Leu Gly Gln Gly Glu  His Gln Gln Val Leu  Gln Ala Val 
    1025                 1030                 1035             


Glu Leu  Gln Gly Leu Gly Leu  Ser Phe Ser Ala Cys  Ser Leu Ala 
    1040                 1045                 1050             


Leu Asp  Gln Ala Gln Leu Thr  Pro Leu Leu Arg Ala  Leu Lys Leu 
    1055                 1060                 1065             


His Thr  Ala Leu Arg Glu Leu  Arg Leu Ala Gly Asn  Arg Leu Gly 
    1070                 1075                 1080             


Asp Lys  Cys Val Ala Glu Leu  Val Ala Ala Leu Gly  Thr Met Pro 
    1085                 1090                 1095             


Ser Leu  Ala Leu Leu Asp Leu  Ser Ser Asn His Leu  Gly Pro Glu 
    1100                 1105                 1110             


Gly Leu  Arg Gln Leu Ala Met  Gly Leu Pro Gly Gln  Ala Thr Leu 
    1115                 1120                 1125             


Gln Ser  Leu Glu Glu Leu Asp  Leu Ser Met Asn Pro  Leu Gly Asp 
    1130                 1135                 1140             


Gly Cys  Gly Gln Ser Leu Ala  Ser Leu Leu His Ala  Cys Pro Leu 
    1145                 1150                 1155             


Leu Ser  Thr Leu Arg Leu Gln  Ala Cys Gly Phe Gly  Pro Ser Phe 
    1160                 1165                 1170             


Phe Leu  Ser His Gln Thr Ala  Leu Gly Ser Ala Phe  Gln Asp Ala 
    1175                 1180                 1185             


Glu His  Leu Lys Thr Leu Ser  Leu Ser Tyr Asn Ala  Leu Gly Ala 
    1190                 1195                 1200             


Pro Ala  Leu Ala Arg Thr Leu  Gln Ser Leu Pro Ala  Gly Thr Leu 
    1205                 1210                 1215             


Leu His  Leu Glu Leu Ser Ser  Val Ala Ala Gly Lys  Gly Asp Ser 
    1220                 1225                 1230             


Asp Leu  Met Glu Pro Val Phe  Arg Tyr Leu Ala Lys  Glu Gly Cys 
    1235                 1240                 1245             


Ala Leu  Ala His Leu Thr Leu  Ser Ala Asn His Leu  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Arg Asp Leu Cys Arg  Cys Leu Ser Leu Cys  Pro Ser Leu 
    1265                 1270                 1275             


Ile Ser  Leu Asp Leu Ser Ala  Asn Pro Glu Ile Ser  Cys Ala Ser 
    1280                 1285                 1290             


Leu Glu  Glu Leu Leu Ser Thr  Leu Gln Lys Arg Pro  Gln Gly Leu 
    1295                 1300                 1305             


Ser Phe  Leu Gly Leu Ser Gly  Cys Ala Val Gln Gly  Pro Leu Gly 
    1310                 1315                 1320             


Leu Gly  Leu Trp Asp Lys Ile  Ala Ala Gln Leu Arg  Glu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Ser Arg Arg Leu Cys  Ala Glu Asp Arg Asp  Ala Leu Arg 
    1340                 1345                 1350             


Gln Leu  Gln Pro Ser Arg Pro  Gly Pro Gly Glu Cys  Thr Leu Asp 
    1355                 1360                 1365             


His Gly  Ser Lys Leu Phe Phe  Arg Arg Leu 
    1370                 1375             


<210>  22
<211>  1378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant protein

<400>  22

Met Ser Leu Glu Arg Glu Leu Arg Gln Leu Ser Lys Ala Lys Ala Lys 
1               5                   10                  15      


Ala Gln Arg Ala Gly Gln Arg Arg Glu Glu Ala Ala Leu Cys His Gln 
            20                  25                  30          


Leu Gly Glu Leu Leu Ala Gly His Gly Arg Tyr Ala Glu Ala Leu Glu 
        35                  40                  45              


Gln His Trp Gln Glu Leu Gln Leu Arg Glu Arg Ala Asp Asp Pro Leu 
    50                  55                  60                  


Gly Cys Ala Val Ala His Arg Lys Ile Gly Glu Arg Leu Ala Glu Met 
65                  70                  75                  80  


Glu Asp Tyr Pro Ala Ala Leu Gln His Gln His Gln Tyr Leu Glu Leu 
                85                  90                  95      


Ala His Ser Leu Arg Asn His Thr Glu Leu Gln Arg Ala Trp Ala Thr 
            100                 105                 110         


Ile Gly Arg Thr His Leu Asp Ile Tyr Asp His Cys Gln Ser Arg Asp 
        115                 120                 125             


Ala Leu Leu Gln Ala Gln Ala Ala Phe Glu Lys Ser Leu Ala Ile Val 
    130                 135                 140                 


Asp Glu Glu Leu Glu Gly Thr Leu Ala Gln Gly Glu Leu Asn Glu Met 
145                 150                 155                 160 


Arg Thr Arg Leu Tyr Leu Asn Leu Gly Leu Thr Phe Glu Ser Leu Gln 
                165                 170                 175     


Gln Thr Ala Leu Cys Asn Asp Tyr Phe Arg Lys Ser Ile Phe Leu Ala 
            180                 185                 190         


Glu Gln Asn His Leu Tyr Glu Asp Leu Phe Arg Ala Arg Tyr Asn Leu 
        195                 200                 205             


Gly Thr Ile His Trp Arg Ala Gly Gln His Ser Gln Ala Met Arg Cys 
    210                 215                 220                 


Leu Glu Gly Ala Arg Glu Cys Ala His Thr Met Arg Lys Arg Phe Met 
225                 230                 235                 240 


Glu Ser Glu Cys Cys Val Val Ile Ala Gln Val Leu Gln Asp Leu Gly 
                245                 250                 255     


Asp Phe Leu Ala Ala Lys Arg Ala Leu Lys Lys Ala Tyr Arg Leu Gly 
            260                 265                 270         


Ser Gln Lys Pro Val Gln Arg Ala Ala Ile Cys Gln Asn Leu Gln His 
        275                 280                 285             


Val Leu Ala Val Val Arg Leu Gln Gln Gln Leu Glu Glu Ala Glu Gly 
    290                 295                 300                 


Arg Asp Pro Gln Gly Ala Met Val Ile Cys Glu Gln Leu Gly Asp Leu 
305                 310                 315                 320 


Phe Ser Lys Ala Gly Asp Phe Pro Arg Ala Ala Glu Ala Tyr Gln Lys 
                325                 330                 335     


Gln Leu Arg Phe Ala Glu Leu Leu Asp Arg Pro Gly Ala Glu Arg Ala 
            340                 345                 350         


Ile Ile His Val Ser Leu Ala Thr Thr Leu Gly Asp Met Lys Asp His 
        355                 360                 365             


His Gly Ala Val Arg His Tyr Glu Glu Glu Leu Arg Leu Arg Ser Gly 
    370                 375                 380                 


Asn Val Leu Glu Glu Ala Lys Thr Trp Leu Asn Ile Ala Leu Ser Arg 
385                 390                 395                 400 


Glu Glu Ala Gly Asp Ala Tyr Glu Leu Leu Ala Pro Cys Phe Gln Lys 
                405                 410                 415     


Ala Leu Ser Cys Ala Gln Gln Ala Gln Arg Pro Gln Leu Gln Arg Gln 
            420                 425                 430         


Val Leu Gln His Leu His Thr Val Gln Leu Arg Leu Gln Pro Gln Glu 
        435                 440                 445             


Ala Pro Glu Thr Glu Thr Arg Leu Arg Glu Leu Ser Val Ala Glu Asp 
    450                 455                 460                 


Glu Asp Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Thr Ala Glu Ser 
465                 470                 475                 480 


Glu Ala Leu Glu Ala Gly Glu Val Glu Leu Ser Glu Gly Glu Asp Asp 
                485                 490                 495     


Thr Asp Gly Leu Thr Pro Gln Leu Glu Glu Asp Glu Glu Leu Gln Gly 
            500                 505                 510         


His Leu Gly Arg Arg Lys Gly Ser Lys Trp Asn Arg Arg Asn Asp Met 
        515                 520                 525             


Gly Glu Thr Leu Leu His Arg Ala Cys Ile Glu Gly Gln Leu Arg Arg 
    530                 535                 540                 


Val Gln Asp Leu Val Arg Gln Gly His Pro Leu Asn Pro Arg Asp Tyr 
545                 550                 555                 560 


Cys Gly Trp Thr Pro Leu His Glu Ala Cys Asn Tyr Gly His Leu Glu 
                565                 570                 575     


Ile Val Arg Phe Leu Leu Asp His Gly Ala Ala Val Asp Asp Pro Gly 
            580                 585                 590         


Gly Gln Gly Cys Glu Gly Ile Thr Pro Leu His Ala Ala Leu Asn Cys 
        595                 600                 605             


Gly His Phe Glu Val Ala Glu Leu Leu Leu Glu Arg Gly Ala Ser Val 
    610                 615                 620                 


Thr Leu Arg Thr Arg Lys Gly Leu Ser Pro Leu Glu Thr Leu Gln Gln 
625                 630                 635                 640 


Trp Val Lys Leu Tyr Arg Arg Asp Leu Asp Leu Glu Thr Arg Gln Lys 
                645                 650                 655     


Ala Arg Ala Met Glu Met Leu Leu Gln Ala Ala Ala Ser Gly Gln Asp 
            660                 665                 670         


Pro His Ser Ser Gln Ala Phe His Thr Pro Ser Ser Leu Leu Phe Asp 
        675                 680                 685             


Pro Glu Thr Ser Pro Pro Leu Ser Pro Cys Pro Glu Pro Pro Ser Asn 
    690                 695                 700                 


Ser Thr Arg Leu Pro Glu Ala Ser Gln Ala His Val Arg Val Ser Pro 
705                 710                 715                 720 


Gly Gln Ala Ala Pro Ala Met Ala Arg Pro Arg Arg Ser Arg His Gly 
                725                 730                 735     


Pro Ala Ser Ser Ser Ser Ser Ser Glu Gly Glu Asp Ser Ala Gly Pro 
            740                 745                 750         


Ala Arg Pro Ser Gln Lys Arg Pro Arg Cys Ser Ala Thr Ala Gln Arg 
        755                 760                 765             


Val Ala Ala Trp Thr Pro Gly Pro Ala Ser Asn Arg Glu Ala Ala Thr 
    770                 775                 780                 


Ala Ser Thr Ser Arg Ala Ala Tyr Gln Ala Ala Ile Arg Gly Val Gly 
785                 790                 795                 800 


Ser Ala Gln Ser Arg Leu Gly Pro Gly Pro Pro Arg Gly His Ser Lys 
                805                 810                 815     


Ala Leu Ala Pro Gln Ala Ala Leu Ile Pro Glu Glu Glu Cys Leu Ala 
            820                 825                 830         


Gly Asp Trp Leu Glu Leu Asp Met Pro Leu Thr Arg Ser Arg Arg Pro 
        835                 840                 845             


Arg Pro Arg Gly Thr Gly Asp Asn Arg Arg Pro Ser Ser Thr Ser Gly 
    850                 855                 860                 


Ser Asp Ser Glu Glu Ser Arg Pro Arg Ala Arg Ala Lys Gln Val Arg 
865                 870                 875                 880 


Leu Thr Cys Met Gln Ser Cys Ser Ala Pro Val Asn Ala Gly Pro Ser 
                885                 890                 895     


Ser Leu Ala Ser Glu Pro Pro Gly Ser Pro Ser Thr Pro Arg Val Ser 
            900                 905                 910         


Glu Pro Ser Gly Asp Ser Ser Ala Ala Gly Gln Pro Leu Gly Pro Ala 
        915                 920                 925             


Pro Pro Pro Pro Ile Arg Val Arg Val Gln Val Gln Asp His Leu Phe 
    930                 935                 940                 


Leu Ile Pro Val Pro His Ser Ser Asp Thr His Ser Val Ala Trp Leu 
945                 950                 955                 960 


Ala Glu Gln Ala Ala Gln Arg Tyr Tyr Gln Thr Cys Gly Leu Leu Pro 
                965                 970                 975     


Arg Leu Thr Leu Arg Lys Glu Gly Ala Leu Leu Ala Pro Gln Asp Leu 
            980                 985                 990         


Ile Pro Asp Val Leu Gln Ser Asn  Asp Glu Val Leu Ala  Glu Val Thr 
        995                 1000                 1005             


Ser Trp  Asp Leu Pro Pro Leu  Thr Asp Arg Tyr Arg  Arg Ala Cys 
    1010                 1015                 1020             


Gln Ser  Leu Gly Gln Gly Glu  His Gln Gln Val Leu  Gln Ala Val 
    1025                 1030                 1035             


Glu Leu  Gln Gly Leu Gly Leu  Ser Phe Ser Ala Cys  Ser Leu Ala 
    1040                 1045                 1050             


Leu Asp  Gln Ala Gln Leu Thr  Pro Leu Leu Arg Ala  Leu Lys Leu 
    1055                 1060                 1065             


His Thr  Ala Leu Arg Glu Leu  Arg Leu Ala Gly Asn  Arg Leu Gly 
    1070                 1075                 1080             


Asp Lys  Cys Val Ala Glu Leu  Val Ala Ala Leu Gly  Thr Met Pro 
    1085                 1090                 1095             


Ser Leu  Ala Leu Leu Asp Leu  Ser Ser Asn His Leu  Gly Pro Glu 
    1100                 1105                 1110             


Gly Leu  Arg Gln Leu Ala Met  Gly Leu Pro Gly Gln  Ala Thr Leu 
    1115                 1120                 1125             


Gln Ser  Leu Glu Glu Leu Asp  Leu Ser Met Asn Pro  Leu Gly Asp 
    1130                 1135                 1140             


Gly Cys  Gly Gln Ser Leu Ala  Ser Leu Leu His Ala  Cys Pro Leu 
    1145                 1150                 1155             


Leu Ser  Thr Leu Arg Leu Gln  Ala Cys Gly Phe Gly  Pro Ser Phe 
    1160                 1165                 1170             


Phe Leu  Ser His Gln Thr Ala  Leu Gly Ser Ala Phe  Gln Asp Ala 
    1175                 1180                 1185             


Glu His  Leu Lys Thr Leu Ser  Leu Ser Tyr Asn Ala  Leu Gly Ala 
    1190                 1195                 1200             


Pro Ala  Leu Ala Arg Thr Leu  Gln Ser Leu Pro Ala  Gly Thr Leu 
    1205                 1210                 1215             


Leu His  Leu Glu Leu Ser Ser  Val Ala Ala Gly Lys  Gly Asp Ser 
    1220                 1225                 1230             


Asp Leu  Met Glu Pro Val Phe  Arg Tyr Leu Ala Lys  Glu Gly Cys 
    1235                 1240                 1245             


Ala Leu  Ala His Leu Thr Leu  Ser Ala Asn His Leu  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Arg Asp Leu Cys Arg  Cys Leu Ser Leu Cys  Pro Ser Leu 
    1265                 1270                 1275             


Ile Ser  Leu Asp Leu Ser Ala  Asn Pro Glu Ile Ser  Cys Ala Ser 
    1280                 1285                 1290             


Leu Glu  Glu Leu Leu Ser Thr  Leu Gln Lys Arg Pro  Gln Gly Leu 
    1295                 1300                 1305             


Ser Phe  Leu Gly Leu Ser Gly  Cys Ala Val Gln Gly  Pro Leu Gly 
    1310                 1315                 1320             


Leu Gly  Leu Trp Asp Lys Ile  Ala Ala Gln Leu Arg  Glu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Ser Arg Arg Leu Cys  Ala Glu Asp Arg Asp  Ala Leu Arg 
    1340                 1345                 1350             


Gln Leu  Gln Pro Ser Arg Pro  Gly Pro Gly Glu Cys  Thr Leu Asp 
    1355                 1360                 1365             


His Gly  Ser Lys Leu Phe Phe  Arg Arg Leu 
    1370                 1375             


<210>  23
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      


Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          


Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              


Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  


Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      


Thr Leu Tyr Gly Phe Gly Gly 
            100             


<210>  24
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Glu Ser Ser Glu Ser Phe Thr Met Ala Ser Ser Pro Ala Gln 
1               5                   10                  15      


Arg Arg Arg Gly Asn Asp Pro Leu Thr Ser Ser Pro Gly Arg Ser Ser 
            20                  25                  30          


Arg Arg Thr Asp Ala Leu Thr Ser Ser Pro Gly Arg Asp Leu Pro Pro 
        35                  40                  45              


Phe Glu Asp Glu Ser Glu Gly Leu Leu Gly Thr Glu Gly Pro Leu Glu 
    50                  55                  60                  


Glu Glu Glu Asp Gly Glu Glu Leu Ile Gly Asp Gly Met Glu Arg Asp 
65                  70                  75                  80  


Tyr Arg Ala Ile Pro Glu Leu Asp Ala Tyr Glu Ala Glu Gly Leu Ala 
                85                  90                  95      


Leu Asp Asp Glu Asp Val Glu Glu Leu Thr Ala Ser Gln Arg Glu Ala 
            100                 105                 110         


Ala Glu Arg Ala Met Arg Gln Arg Asp Arg Glu Ala Gly Arg Gly Leu 
        115                 120                 125             


Gly Arg Met Arg Arg Gly Leu Leu Tyr Asp Ser Asp Glu Glu Asp Glu 
    130                 135                 140                 


Glu Arg Pro Ala Arg Lys Arg Arg Gln Val Glu Arg Ala Thr Glu Asp 
145                 150                 155                 160 


Gly Glu Glu Asp Glu Glu Met Ile Glu Ser Ile Glu Asn Leu Glu Asp 
                165                 170                 175     


Leu Lys Gly His Ser Val Arg Glu Trp Val Ser Met Ala Gly Pro Arg 
            180                 185                 190         


Leu Glu Ile His His Arg Phe Lys Asn Phe Leu Arg Thr His Val Asp 
        195                 200                 205             


Ser His Gly His Asn Val Phe Lys Glu Arg Ile Ser Asp Met Cys Lys 
    210                 215                 220                 


Glu Asn Arg Glu Ser Leu Val Val Asn Tyr Glu Asp Leu Ala Ala Arg 
225                 230                 235                 240 


Glu His Val Leu Ala Tyr Phe Leu Pro Glu Ala Pro Ala Glu Leu Leu 
                245                 250                 255     


Gln Ile Phe Asp Glu Ala Ala Leu Glu Val Val Leu Ala Met Tyr Pro 
            260                 265                 270         


Lys Tyr Asp Arg Ile Thr Asn His Ile His Val Arg Ile Ser His Leu 
        275                 280                 285             


Pro Leu Val Glu Glu Leu Arg Ser Leu Arg Gln Leu His Leu Asn Gln 
    290                 295                 300                 


Leu Ile Arg Thr Ser Gly Val Val Thr Ser Cys Thr Gly Val Leu Pro 
305                 310                 315                 320 


Gln Leu Ser Met Val Lys Tyr Asn Cys Asn Lys Cys Asn Phe Val Leu 
                325                 330                 335     


Gly Pro Phe Cys Gln Ser Gln Asn Gln Glu Val Lys Pro Gly Ser Cys 
            340                 345                 350         


Pro Glu Cys Gln Ser Ala Gly Pro Phe Glu Val Asn Met Glu Glu Thr 
        355                 360                 365             


Ile Tyr Gln Asn Tyr Gln Arg Ile Arg Ile Gln Glu Ser Pro Gly Lys 
    370                 375                 380                 


Val Ala Ala Gly Arg Leu Pro Arg Ser Lys Asp Ala Ile Leu Leu Ala 
385                 390                 395                 400 


Asp Leu Val Asp Ser Cys Lys Pro Gly Asp Glu Ile Glu Leu Thr Gly 
                405                 410                 415     


Ile Tyr His Asn Asn Tyr Asp Gly Ser Leu Asn Thr Ala Asn Gly Phe 
            420                 425                 430         


Pro Val Phe Ala Thr Val Ile Leu Ala Asn His Val Ala Lys Lys Asp 
        435                 440                 445             


Asn Lys Val Ala Val Gly Glu Leu Thr Asp Glu Asp Val Lys Met Ile 
    450                 455                 460                 


Thr Ser Leu Ser Lys Asp Gln Gln Ile Gly Glu Lys Ile Phe Ala Ser 
465                 470                 475                 480 


Ile Ala Pro Ser Ile Tyr Gly His Glu Asp Ile Lys Arg Gly Leu Ala 
                485                 490                 495     


Leu Ala Leu Phe Gly Gly Glu Pro Lys Asn Pro Gly Gly Lys His Lys 
            500                 505                 510         


Val Arg Gly Asp Ile Asn Val Leu Leu Cys Gly Asp Pro Gly Thr Ala 
        515                 520                 525             


Lys Ser Gln Phe Leu Lys Tyr Ile Glu Lys Val Ser Ser Arg Ala Ile 
    530                 535                 540                 


Phe Thr Thr Gly Gln Gly Ala Ser Ala Val Gly Leu Thr Ala Tyr Val 
545                 550                 555                 560 


Gln Arg His Pro Val Ser Arg Glu Trp Thr Leu Glu Ala Gly Ala Leu 
                565                 570                 575     


Val Leu Ala Asp Arg Gly Val Cys Leu Ile Asp Glu Phe Asp Lys Met 
            580                 585                 590         


Asn Asp Gln Asp Arg Thr Ser Ile His Glu Ala Met Glu Gln Gln Ser 
        595                 600                 605             


Ile Ser Ile Ser Lys Ala Gly Ile Val Thr Ser Leu Gln Ala Arg Cys 
    610                 615                 620                 


Thr Val Ile Ala Ala Ala Asn Pro Ile Gly Gly Arg Tyr Asp Pro Ser 
625                 630                 635                 640 


Leu Thr Phe Ser Glu Asn Val Asp Leu Thr Glu Pro Ile Ile Ser Arg 
                645                 650                 655     


Phe Asp Ile Leu Cys Val Val Arg Asp Thr Val Asp Pro Val Gln Asp 
            660                 665                 670         


Glu Met Leu Ala Arg Phe Val Val Gly Ser His Val Arg His His Pro 
        675                 680                 685             


Ser Asn Lys Glu Glu Glu Gly Leu Ala Asn Gly Ser Ala Ala Glu Pro 
    690                 695                 700                 


Ala Met Pro Asn Thr Tyr Gly Val Glu Pro Leu Pro Gln Glu Val Leu 
705                 710                 715                 720 


Lys Lys Tyr Ile Ile Tyr Ala Lys Glu Arg Val His Pro Lys Leu Asn 
                725                 730                 735     


Gln Met Asp Gln Asp Lys Val Ala Lys Met Tyr Ser Asp Leu Arg Lys 
            740                 745                 750         


Glu Ser Met Ala Thr Gly Ser Ile Pro Ile Thr Val Arg His Ile Glu 
        755                 760                 765             


Ser Met Ile Arg Met Ala Glu Ala His Ala Arg Ile His Leu Arg Asp 
    770                 775                 780                 


Tyr Val Ile Glu Asp Asp Val Asn Met Ala Ile Arg Val Met Leu Glu 
785                 790                 795                 800 


Ser Phe Ile Asp Thr Gln Lys Phe Ser Val Met Arg Ser Met Arg Lys 
                805                 810                 815     


Thr Phe Ala Arg Tyr Leu Ser Phe Arg Arg Asp Asn Asn Glu Leu Leu 
            820                 825                 830         


Leu Phe Ile Leu Lys Gln Leu Val Ala Glu Gln Val Thr Tyr Gln Arg 
        835                 840                 845             


Asn Arg Phe Gly Ala Gln Gln Asp Thr Ile Glu Val Pro Glu Lys Asp 
    850                 855                 860                 


Leu Val Asp Lys Ala Arg Gln Ile Asn Ile His Asn Leu Ser Ala Phe 
865                 870                 875                 880 


Tyr Asp Ser Glu Leu Phe Arg Met Asn Lys Phe Ser His Asp Leu Lys 
                885                 890                 895     


Arg Lys Met Ile Leu Gln Gln Phe 
            900                 


<210>  25
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  26
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be any amino acid

<400>  26

Arg His Xaa Lys 
1               


<210>  27
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be any amino acid

<400>  27

Arg His Xaa Lys Val Leu 
1               5       


<210>  28
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be any amino acid

<400>  28

Arg His Xaa Lys Val Leu Arg 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide

<400>  29

Ala Lys Arg His Arg Lys Val Leu Arg 
1               5                   


<210>  30
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide

<400>  30

Lys Gly Gly Ala Lys Arg His Arg Lys Val Leu Arg 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide

<400>  31

Lys Gly Gly Ala Lys Arg His Ala Lys Val Leu Arg 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide

<400>  32

Lys Gly Gly Ala Ala Arg His Arg Lys Val Leu Arg 
1               5                   10          


<210>  33
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide

<400>  33

Leu Gly Lys Gly Gly Ala Lys Arg His Arg Lys Val Leu Arg Asp Asn 
1               5                   10                  15      


Ile 
    


<210>  34
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys 
1               5                   10                  15      


Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys Pro 
            20                  25                  30          


Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser Gly 
        35                  40                  45              


Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu Asn 
    50                  55                  60                  


Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys Thr 
65                  70                  75                  80  


Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg Thr 
                85                  90                  95      


Leu Tyr Gly Phe Gly Gly 
            100         


