                         SEQUENCE LISTING

<110>  Ionis Pharmaceuticals, Inc.
 
<120>  CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE

<130>  CORE0136WO

<150>  62/399,236
<151>  2016-09-23

<150>  62/333,101
<151>  2016-05-06

<150>  62/233,253
<151>  2015-09-25

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
gccaggctgg ttatgactca                                                   20


<210>  2
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
tcagccaggc tggttatgac tca                                               23


<210>  3
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
gcattctaat agcagc                                                       16


<210>  4
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
tcagcattct aatagcagc                                                    19


<210>  5
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
aggatatgga accaaa                                                       16


<210>  6
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
tcaaggatat ggaaccaaa                                                    19


<210>  7
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
gacaacttgg agcttg                                                       16


<210>  8
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
tcagacaact tggagcttg                                                    19


<210>  9
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
ctggtatgag gcctga                                                       16


<210>  10
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
tcactggtat gaggcctga                                                    19


<210>  11
<211>  16
<212>  DNA
<213>  Artificial sequnece

<220>
<223>  Synthetic oligonucleotide

<400>  11
acaataaata ccgagg                                                       16


<210>  12
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
tcaacaataa ataccgagg                                                    19


<210>  13
<211>  14
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bases at these positions are RNA

<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  bases at these positions are RNA

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  bases at these positions are RNA

<400>  13
cutagcactg gccu                                                         14


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
agcatagtta acgagctccc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
aatggtttat tccatggcca                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
gcagccatgg tgatcaggag                                                   20


<210>  17
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
ggttcccgag gtgccca                                                      17


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
gcacactcag caggaccccc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
ccacctttgg gtgaatagca                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
tgccatttaa tgagcttcac                                                   20


<210>  21
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
tcccgaatgt ccgaca                                                       16


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
atcccacgcc cctgtccagc                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
gcagaggtga agcgaagtgc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
ccaatttatg cctacagcct                                                   20


<210>  25
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
ggcatagcag caggatg                                                      17


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
aggagttccg cagtatggat                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
gtgaagcgaa gtgcacacgg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
gtgcagaggt gaagcgaagt                                                   20


<210>  29
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
aggtgaagcg aagtgc                                                       16


<210>  30
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
tccgcagtat ggatcg                                                       16


<210>  31
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
aatttatgcc tacagcct                                                     18


<210>  32
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
tcttggttac atgaaatccc                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
cttggttaca tgaaatccca                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
ggaatactct tggttacatg                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
tggaatactc ttggttacat                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
ttttattgtc tctgcctgga                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
gaatgtttta ttgtctctgc                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  38
aggaatgttt tattgtctct                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
acaggaatgt tttattgtct                                                   20


<210>  40
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
ggccaatacg ccgtca                                                       16


<210>  41
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  41
ggcaattggt gtttaa                                                       16


<210>  42
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
attcactttc ataatgctgg                                                   20


<210>  43
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
tcactttcat aatgctgg                                                     18


