                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       Walters, Kyle J.
       Lu, Xiuxiu
       Liu, Fen
 
<120>  HUMAN RPN2 DERIVED PEPTIDES USEFUL FOR TREATING CANCER

<130>  E-278-2015/0-US-02

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro Val Ala Ala His 
1               5                   10                  15      


Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu Pro Pro Glu Pro 
            20                  25                  30          


Phe Glu Tyr Ile Asp Asp 
        35              


<210>  2
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST Fusion Protein with 916 to 953 hRpn2

<400>  2

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu Glu Val Leu 
    210                 215                 220                 


Phe Gln Gly Pro Gly SER Asp Thr Ser Glu Asp Ile Glu Glu Leu Val
225                 230                 235                 240 


Glu Pro Val Ala Ala His Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu
                245                 250                 255     


Pro Glu Pro Pro Glu Pro Phe Glu Tyr Ile Asp Asp
            260                 265                     


                    



<210>  3
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Thr Ser Gly Ala Leu Phe Pro Ser Leu Val Pro Gly Ser Arg 
1               5                   10                  15      


Gly Ala Ser Asn Lys Tyr Leu Val Glu Phe Arg Ala Gly Lys Met Ser 
            20                  25                  30          


Leu Lys Gly Thr Thr Val Thr Pro Asp Lys Arg Lys Gly Leu Val Tyr 
        35                  40                  45              


Ile Gln Gln Thr Asp Asp Ser Leu Ile His Phe Cys Trp Lys Asp Arg 
    50                  55                  60                  


Thr Ser Gly Asn Val Glu Asp Asp Leu Ile Ile Phe Pro Asp Asp Cys 
65                  70                  75                  80  


Glu Phe Lys Arg Val Pro Gln Cys Pro Ser Gly Arg Val Tyr Val Leu 
                85                  90                  95      


Lys Phe Lys Ala Gly Ser Lys Arg Leu Phe Phe Trp Met Gln Glu Pro 
            100                 105                 110         


Lys Thr Asp Gln Asp Glu Glu His Cys Arg Lys Val Asn Glu Tyr Leu 
        115                 120                 125             


Asn Asn Pro Pro Met Pro Gly Ala Leu Gly Ala Ser Gly Ser Ser Gly 
    130                 135                 140                 


His Glu Leu Ser Ala Leu 
145                 150 


<210>  4
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Lys Val Gln Tyr Lys Ser Asn Cys Lys Pro Ser Thr Phe Ala 
1               5                   10                  15      


Tyr Pro Ala Pro Leu Glu Val Pro Lys Glu Lys Glu Lys Glu Lys Val 
            20                  25                  30          


Ser Thr Ala Val Leu Ser Ile Thr Ala Lys Ala Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Lys Lys Glu Glu Glu Lys Met Glu Val Asp Glu Ala Glu 
    50                  55                  60                  


Lys Lys Glu Glu Lys Glu Lys Lys Lys Glu Pro Glu Pro Asn Phe Gln 
65                  70                  75                  80  


Leu Leu Asp Asn Pro Ala Arg Val Met Pro Ala Gln Leu Lys Val Leu 
                85                  90                  95      


Thr Met Pro Glu Thr Cys Arg Tyr Gln Pro Phe Lys Pro Leu Ser Ile 
            100                 105                 110         


Gly Gly Ile Ile Ile Leu Lys Asp Thr Ser Glu Asp Ile Glu Glu Leu 
        115                 120                 125             


Val Glu Pro Val Ala Ala His Gly Pro Lys Ile Glu Glu Glu Glu Gln 
    130                 135                 140                 


Glu Pro Glu Pro Pro Glu Pro Phe Glu Tyr Ile Asp Asp 
145                 150                 155         


<210>  5
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N terminal FLAG tagged 916 to 953 hRpn2

<400>  5

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp 
1               5                   10                  15                  20


Asp Asp Lys Leu Ala Ala Ala Asn Ser Asp Thr Ser Glu Asp Ile Glu Glu 
                25                  30                  35      


Leu Val Glu Pro Val Ala Ala His Gly Pro Lys Ile Glu Glu Glu Glu 
        40                  45                  50          


Gln Glu Pro Glu Pro Pro Glu Pro Phe Glu Tyr Ile Asp Asp 
    55                  60                  65      


<210>  6
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRpn 2 F948R

<400>  6

Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro Val Ala Ala His 
1               5                   10                  15      


Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu Pro Pro Glu Pro 
            20                  25                  30          


Arg Glu Tyr Ile Asp Asp 
        35              


<210>  7
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro Val Ala Ala His 
1               5                   10                  15      


Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu Pro Pro Glu Pro 
            20                  25                  30          


<210>  8
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRpn 2 Y950D I951D

<400>  8

Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro Val Ala Ala His 
1               5                   10                  15      


Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu Pro Pro Glu Pro 
            20                  25                  30          


Phe Glu Asp Asp Asp Asp 
        35              


<210>  9
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRpn 2 F948R Y950D I951D

<400>  9

Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro Val Ala Ala His 
1               5                   10                  15      


Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu Pro Pro Glu Pro 
            20                  25                  30          


Arg Glu Asp Asp Asp Asp 
        35              


<210>  10
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Glu Pro Glu Pro Pro Glu Pro Phe Glu Tyr Ile Asp Asp 
1               5                   10                  


<210>  11
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Glu Pro Glu Pro Pro Glu Pro Phe Glu Tyr Ile Asp 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRpn2 940-952


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is selected from any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is selected from any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is selected from any amino acid

<400>  12

Xaa Xaa Pro Xaa Pro Pro Xaa Pro Phe Xaa Tyr Ile Asp 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRpn2 940-952


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is selected from any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is selected from any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is selected from any amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is selected from any amino acid

<400>  13

Xaa Xaa Pro Xaa Pro Pro Xaa Pro Phe Xaa Tyr Ile Xaa 
1               5                   10              


