                               SEQUENCE LISTING

<110> BOSTON MEDICAL CENTER CORPORATION
 
<120> BIOMARKERS FOR THE EARLY DETECTION OF PARKINSON'S DISEASE

<130> 701586-085822-PCT

<140> PCT/US2016/053330
<141> 2016-09-23

<150> 62/232,199
<151> 2015-09-24

<150> 62/222,619
<151> 2015-09-23

<160> 18    

<170> PatentIn version 3.5

<210> 1
<211> 3240
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2770)..(2770)
<223> a, c, t, g, unknown or other

<400> 1
ctgggggtcc gttccccaac ttcctcggcg ctccggactc ccaagtctcc gccggaccct       60

cctttggata ttcctcgtgt ctccgattct gagagagggg gaagacggtg gggcctcccc      120

acctgccccg cagaagatgc agttctttgg ccgcctggtc aataccttca gtggcgtcac      180

caacttgttc tctaacccat tccgggtgaa ggaggtggct gtggccgact acacctcgag      240

tgaccgagtt cgggaggaag ggcagctgat tctgttccag aacactccca accgcacctg      300

ggactgcgtc ctggtcaacc ccaggaactc acagagtgga ttccgactct tccagctgga      360

gttggaggct gacgccctag tgaatttcca tcagtattct tcccagctgc tacccttcta      420

tgagagctcc cctcaggtcc tgcacactga ggtcctgcag cacctgaccg acctcatccg      480

taaccacccc agctggtcag tggcccacct ggctgtggag ctagggatcc gcgagtgctt      540

ccatcacagc cgtatcatca gctgtgccaa ttgcgcggag aacgaggagg gctgcacacc      600

cctgcacctg gcctgccgca agggtgatgg ggagatcctg gtggagctgg tgcagtactg      660

ccacactcag atggatgtca ccgactacaa gggagagacc gtcttccatt atgctgtcca      720

gggtgacaat tctcaggtgc tgcagctcct tggaaggaac gcagtggctg gcctgaacca      780

ggtgaataac caagggctga ccccgctgca cctggcctgc cagctgggga agcaggagat      840

ggtccgcgtg ctgctgctgt gcaatgctcg gtgcaacatc atgggcccca acggctaccc      900

catccactcg gccatgaagt tctctcagaa ggggtgtgcg gagatgatca tcagcatgga      960

cagcagccag atccacagca aagacccccg ttacggagcc agccccctcc actgggccaa     1020

gaacgcagag atggcccgca tgctgctgaa acggggctgc aacgtgaaca gcaccagctc     1080

cgcggggaac acggccctgc acgtggcggt gatgcgcaac cgcttcgact gtgccatagt     1140

gctgctgacc cacggggcca acgcggatgc ccgcggagag cacggcaaca ccccgctgca     1200

cctggccatg tcgaaagaca acgtggagat gatcaaggcc ctcatcgtgt tcggagcaga     1260

agtggacacc ccgaatgact ttggggagac tcctacattc ctagcctcca aaatcggcag     1320

acttgtcacc aggaaggcga tcttgactct gctgagaacc gtgggggccg aatactgctt     1380

cccacccatc cacggggtcc ccgcggagca gggctctgca gcgccacatc atcccttctc     1440

cctggaaaga gctcagcccc caccgatcag cctaaacaac ctagaactac aggatctcat     1500

gcacatctca cgggcccgga agccagcgtt catcctgggc tccatgaggg acgagaagcg     1560

gacccacgac cacctgctgt gcctggatgg aggaggagtg aaaggcctca tcatcatcca     1620

gctcctcatc gccatcgaga aggcctcggg tgtggccacc aaggacctgt ttgactgggt     1680

ggcgggcacc agcactggag gcatcctggc cctggccatt ctgcacagta agtccatggc     1740

ctacatgcgc ggcatgtact ttcgcatgaa ggatgaggtg ttccggggct ccaggcccta     1800

cgagtcgggg cccctggagg agttcctgaa gcgggagttt ggggagcaca ccaagatgac     1860

ggacgtcagg aaacccaagg tgatgctgac agggacactg tctgaccggc agccggctga     1920

actccacctc ttccggaact acgatgctcc agaaactgtc cgggagcctc gtttcaacca     1980

gaacgttaac ctcaggcctc cagctcagcc ctcagaccag ctggtgtggc gggcggcccg     2040

aagcagcggg gcagctccta cttacttccg acccaatggg cgcttcctgg acggtgggct     2100

gctggccaac aaccccacgc tggatgccat gaccgagatc catgagtaca atcaggacct     2160

gatccgcaag ggtcaggcca acaaggtgaa gaaactctcc atcgttgtct ccctggggac     2220

agggaggtcc ccacaagtgc ctgtgacctg tgtggatgtc ttccgtccca gcaacccctg     2280

ggagctggcc aagactgttt ttggggccaa ggaactgggc aagatggtgg tggactgttg     2340

cacggatcca gacgggcggg ctgtggaccg ggcacgggcc tggtgcgaga tggtcggcat     2400

ccagtacttc agattgaacc cccagctggg gacggacatc atgctggatg aggtcagtga     2460

cacagtgctg gtcaacgccc tctgggagac cgaggtctac atctatgagc accgcgagga     2520

gttccagaag ctcatccacc tgctgctctc accctgaggg tccccagcct ctcaccggcc     2580

ccagctgacc tcgtccattc agcccctgcc aggccaagcc cagccactgc cctcccgggc     2640

agatctgggc ccaggcacct ctgagtccat agaccaggcc tgggagaatg ccaagctgcc     2700

tgcccgaggc tggtcctgaa ggcctgtctc ccactaaccc ccccttccat cactttctgt     2760

catgccaggn tgggaaagtc tagagccccc tttggcccct ttccctgact gtcaaggaca     2820

actgactccc ccatcagctc aaacattaag ggtacccggg cacaaccgta cccgtgcccc     2880

cagccccagc ctaccctgag ggcctgccgg gctgcctttg ccccagcccc cagcaagggc     2940

attcccaggc ttcctggtgg gtgcagccca atccctctgc cctctgctcc gttccctggg     3000

ggctgggact aaagaaatgg gtgtccccca ccccatcagc tgggaaagcc caggccgcag     3060

gagtgggatg cccgttggac tttgcccctc acactggccc agcccctcac actgccccac     3120

cccgagaacc ctcagctctc aaaggtcact cctgggagtt tcttcttccc aatggaagtg     3180

gcttaagagc caaaactgaa ataaatcatt tggattcaag ttcaaaaaaa aaaaaaaaaa     3240


<210> 2
<211> 806
<212> PRT
<213> Homo sapiens

<400> 2
Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys 
385                 390                 395                 400 


Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro 
                405                 410                 415     


Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His 
            420                 425                 430         


Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn 
        435                 440                 445             


Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala 
    450                 455                 460                 


Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu 
465                 470                 475                 480 


Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu 
                485                 490                 495     


Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe 
            500                 505                 510         


Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile 
        515                 520                 525             


Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met 
    530                 535                 540                 


Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu 
545                 550                 555                 560 


Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp 
                565                 570                 575     


Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln 
            580                 585                 590         


Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val 
        595                 600                 605             


Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln 
    610                 615                 620                 


Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala 
625                 630                 635                 640 


Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu 
                645                 650                 655     


Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn 
            660                 665                 670         


Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser 
        675                 680                 685             


Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr 
    690                 695                 700                 


Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr 
705                 710                 715                 720 


Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr 
                725                 730                 735     


Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met 
            740                 745                 750         


Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile 
        755                 760                 765             


Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu 
    770                 775                 780                 


Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile 
785                 790                 795                 800 


His Leu Leu Leu Ser Pro 
                805     


<210> 3
<211> 3077
<212> DNA
<213> Homo sapiens

<400> 3
gggggtccgt tccccaactt cctcggcgct ccggactccc aagtctccgc cggaccctcc       60

tttggatatt cctcgtgtct ccgattctga gacagagggg gaagacggtg gggcctcccc      120

acctgccccg cagaagatgc agttctttgg ccgcctggtc aataccttca gtggcgtcac      180

caacttgttc tctaacccat tccgggtgaa ggaggtggct gtggccgact acacctcgag      240

tgaccgagtt cgggaggaag ggcagctgat tctgttccag aacactccca accgcacctg      300

ggactgcgtc ctggtcaacc ccaggaactc acagagtgga ttccgactct tccagctgga      360

gttggaggct gacgccctag tgaatttcca tcagtattct tcccagctgc tacccttcta      420

tgagagctcc cctcaggtcc tgcacactga ggtcctgcag cacctgaccg acctcatccg      480

taaccacccc agctggtcag tggcccacct ggctgtggag ctagggatcc gcgagtgctt      540

ccatcacagc cgtatcatca gctgtgccaa ttgcgcggag aacgaggagg gctgcacacc      600

cctgcacctg gcctgccgca agggtgatgg ggagatcctg gtggagctgg tgcagtactg      660

ccacactcag atggatgtca ccgactacaa gggagagacc gtcttccatt atgctgtcca      720

gggtgacaat tctcaggtgc tgcagctcct tggaaggaac gcagtggctg gcctgaacca      780

ggtgaataac caagggctga ccccgctgca cctggcctgc cagctgggga agcaggagat      840

ggtccgcgtg ctgctgctgt gcaatgctcg gtgcaacatc atgggcccca acggctaccc      900

catccactcg gccatgaagt tctctcagaa ggggtgtgcg gagatgatca tcagcatgga      960

cagcagccag atccacagca aagacccccg ttacggagcc agccccctcc actgggccaa     1020

gaacgcagag atggcccgca tgctgctgaa acggggctgc aacgtgaaca gcaccagctc     1080

cgcggggaac acggccctgc acgtggcggt gatgcgcaac cgcttcgact gtgccatagt     1140

gctgctgacc cacggggcca acgcggatgc ccgcggagag cacggcaaca ccccgctgca     1200

cctggccatg tcgaaagaca acgtggagat gatcaaggcc ctcatcgtgt tcggagcaga     1260

agtggacacc ccgaatgact ttggggagac tcctacattc ctagcctcca aaatcggcag     1320

acaactacag gatctcatgc acatctcacg ggcccggaag ccagcgttca tcctgggctc     1380

catgagggac gagaagcgga cccacgacca cctgctgtgc ctggatggag gaggagtgaa     1440

aggcctcatc atcatccagc tcctcatcgc catcgagaag gcctcgggtg tggccaccaa     1500

ggacctgttt gactgggtgg cgggcaccag cactggaggc atcctggccc tggccattct     1560

gcacagtaag tccatggcct acatgcgcgg catgtacttt cgcatgaagg atgaggtgtt     1620

ccggggctcc aggccctacg agtcggggcc cctggaggag ttcctgaagc gggagtttgg     1680

ggagcacacc aagatgacgg acgtcaggaa acccaaggtg atgctgacag ggacactgtc     1740

tgaccggcag ccggctgaac tccacctctt ccggaactac gatgctccag aaactgtccg     1800

ggagcctcgt ttcaaccaga acgttaacct caggcctcca gctcagccct cagaccagct     1860

ggtgtggcgg gcggcccgaa gcagcggggc agctcctact tacttccgac ccaatgggcg     1920

cttcctggac ggtgggctgc tggccaacaa ccccacgctg gatgccatga ccgagatcca     1980

tgagtacaat caggacctga tccgcaaggg tcaggccaac aaggtgaaga aactctccat     2040

cgttgtctcc ctggggacag ggaggtcccc acaagtgcct gtgacctgtg tggatgtctt     2100

ccgtcccagc aacccctggg agctggccaa gactgttttt ggggccaagg aactgggcaa     2160

gatggtggtg gactgttgca cggatccaga cgggcgggct gtggaccggg cacgggcctg     2220

gtgcgagatg gtcggcatcc agtacttcag attgaacccc cagctgggga cggacatcat     2280

gctggatgag gtcagtgaca cagtgctggt caacgccctc tgggagaccg aggtctacat     2340

ctatgagcac cgcgaggagt tccagaagct catccagctg ctgctctcac cctgagggtc     2400

cccagcctct caccggcccc agctgacctc gtccattcag cccctgccag gccaagccca     2460

gccactgccc tcccgggcag atctgggccc aggcacctct gagtccatag accaggcctg     2520

ggagaatgcc aagctgcctg cccgaggctg gtcctgaagg cctgtctccc actaaccccg     2580

ccttccagca ctttctgtca ttccaggctg ggaaagtcta gagccccctt tggccccttt     2640

ccctgactgt caaggacaac tgactccccc atcagctcaa acattaaggg tacccgggca     2700

caaccgtacc cctgccccca gccccagcct ccctgagggc ctgccgggct gcctctgccc     2760

cagcccccag caagggcact cccaggcttc ctggtgggtg cagcccactc cctctgccct     2820

ctgctccgtt ccctgggggc tgggactaaa gaaatgggtg tcccccaccc catcagctgg     2880

gaaagcccag gccgcaggag tgggatgccc gttggacttt gcccctcaca ctggcccagc     2940

ccctcacact gccccacccc gagaaccctc agctctcaaa ggtcactcct gggagtttct     3000

tcttcccaat ggaagtggct taagagccaa aactgaaata aatcatttgg attcaagttc     3060

aaaaaaaaaa aaaaaaa                                                    3077


<210> 4
<211> 752
<212> PRT
<213> Homo sapiens

<400> 4
Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn 
545                 550                 555                 560 


Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210> 5
<211> 3032
<212> DNA
<213> Homo sapiens

<400> 5
tttgtttgcg gaagtaggag gaagtagaag tgctgagtaa gccgagacag agggggaaga       60

cggtggggcc tccccacctg ccccgcagaa gatgcagttc tttggccgcc tggtcaatac      120

cttcagtggc gtcaccaact tgttctctaa cccattccgg gtgaaggagg tggctgtggc      180

cgactacacc tcgagtgacc gagttcggga ggaagggcag ctgattctgt tccagaacac      240

tcccaaccgc acctgggact gcgtcctggt caaccccagg aactcacaga gtggattccg      300

actcttccag ctggagttgg aggctgacgc cctagtgaat ttccatcagt attcttccca      360

gctgctaccc ttctatgaga gctcccctca ggtcctgcac actgaggtcc tgcagcacct      420

gaccgacctc atccgtaacc accccagctg gtcagtggcc cacctggctg tggagctagg      480

gatccgcgag tgcttccatc acagccgtat catcagctgt gccaattgcg cggagaacga      540

ggagggctgc acacccctgc acctggcctg ccgcaagggt gatggggaga tcctggtgga      600

gctggtgcag tactgccaca ctcagatgga tgtcaccgac tacaagggag agaccgtctt      660

ccattatgct gtccagggtg acaattctca ggtgctgcag ctccttggaa ggaacgcagt      720

ggctggcctg aaccaggtga ataaccaagg gctgaccccg ctgcacctgg cctgccagct      780

ggggaagcag gagatggtcc gcgtgctgct gctgtgcaat gctcggtgca acatcatggg      840

ccccaacggc taccccatcc actcggccat gaagttctct cagaaggggt gtgcggagat      900

gatcatcagc atggacagca gccagatcca cagcaaagac ccccgttacg gagccagccc      960

cctccactgg gccaagaacg cagagatggc ccgcatgctg ctgaaacggg gctgcaacgt     1020

gaacagcacc agctccgcgg ggaacacggc cctgcacgtg gcggtgatgc gcaaccgctt     1080

cgactgtgcc atagtgctgc tgacccacgg ggccaacgcg gatgcccgcg gagagcacgg     1140

caacaccccg ctgcacctgg ccatgtcgaa agacaacgtg gagatgatca aggccctcat     1200

cgtgttcgga gcagaagtgg acaccccgaa tgactttggg gagactccta cattcctagc     1260

ctccaaaatc ggcagacaac tacaggatct catgcacatc tcacgggccc ggaagccagc     1320

gttcatcctg ggctccatga gggacgagaa gcggacccac gaccacctgc tgtgcctgga     1380

tggaggagga gtgaaaggcc tcatcatcat ccagctcctc atcgccatcg agaaggcctc     1440

gggtgtggcc accaaggacc tgtttgactg ggtggcgggc accagcactg gaggcatcct     1500

ggccctggcc attctgcaca gtaagtccat ggcctacatg cgcggcatgt actttcgcat     1560

gaaggatgag gtgttccggg gctccaggcc ctacgagtcg gggcccctgg aggagttcct     1620

gaagcgggag tttggggagc acaccaagat gacggacgtc aggaaaccca aggtgatgct     1680

gacagggaca ctgtctgacc ggcagccggc tgaactccac ctcttccgga actacgatgc     1740

tccagaaact gtccgggagc ctcgtttcaa ccagaacgtt aacctcaggc ctccagctca     1800

gccctcagac cagctggtgt ggcgggcggc ccgaagcagc ggggcagctc ctacttactt     1860

ccgacccaat gggcgcttcc tggacggtgg gctgctggcc aacaacccca cgctggatgc     1920

catgaccgag atccatgagt acaatcagga cctgatccgc aagggtcagg ccaacaaggt     1980

gaagaaactc tccatcgttg tctccctggg gacagggagg tccccacaag tgcctgtgac     2040

ctgtgtggat gtcttccgtc ccagcaaccc ctgggagctg gccaagactg tttttggggc     2100

caaggaactg ggcaagatgg tggtggactg ttgcacggat ccagacgggc gggctgtgga     2160

ccgggcacgg gcctggtgcg agatggtcgg catccagtac ttcagattga acccccagct     2220

ggggacggac atcatgctgg atgaggtcag tgacacagtg ctggtcaacg ccctctggga     2280

gaccgaggtc tacatctatg agcaccgcga ggagttccag aagctcatcc agctgctgct     2340

ctcaccctga gggtccccag cctctcaccg gccccagctg acctcgtcca ttcagcccct     2400

gccaggccaa gcccagccac tgccctcccg ggcagatctg ggcccaggca cctctgagtc     2460

catagaccag gcctgggaga atgccaagct gcctgcccga ggctggtcct gaaggcctgt     2520

ctcccactaa ccccgccttc cagcactttc tgtcattcca ggctgggaaa gtctagagcc     2580

ccctttggcc cctttccctg actgtcaagg acaactgact cccccatcag ctcaaacatt     2640

aagggtaccc gggcacaacc gtacccctgc ccccagcccc agcctccctg agggcctgcc     2700

gggctgcctc tgccccagcc cccagcaagg gcactcccag gcttcctggt gggtgcagcc     2760

cactccctct gccctctgct ccgttccctg ggggctggga ctaaagaaat gggtgtcccc     2820

caccccatca gctgggaaag cccaggccgc aggagtggga tgcccgttgg actttgcccc     2880

tcacactggc ccagcccctc acactgcccc accccgagaa ccctcagctc tcaaaggtca     2940

ctcctgggag tttcttcttc ccaatggaag tggcttaaga gccaaaactg aaataaatca     3000

tttggattca agttcaaaaa aaaaaaaaaa aa                                   3032


<210> 6
<211> 752
<212> PRT
<213> Homo sapiens

<400> 6
Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn 
1               5                   10                  15      


Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr 
            20                  25                  30          


Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln 
        35                  40                  45              


Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn 
    50                  55                  60                  


Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala 
65                  70                  75                  80  


Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu 
                85                  90                  95      


Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp 
            100                 105                 110         


Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu 
        115                 120                 125             


Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala 
    130                 135                 140                 


Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys 
145                 150                 155                 160 


Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His 
                165                 170                 175     


Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr 
            180                 185                 190         


Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn 
        195                 200                 205             


Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu 
    210                 215                 220                 


His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu 
225                 230                 235                 240 


Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile 
                245                 250                 255     


His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile 
            260                 265                 270         


Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala 
        275                 280                 285             


Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu 
    290                 295                 300                 


Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala 
305                 310                 315                 320 


Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu 
                325                 330                 335     


Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr 
            340                 345                 350         


Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala 
        355                 360                 365             


Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu 
    370                 375                 380                 


Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Gln Leu Gln Asp Leu 
385                 390                 395                 400 


Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser Met 
                405                 410                 415     


Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly 
            420                 425                 430         


Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys 
        435                 440                 445             


Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr 
    450                 455                 460                 


Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met 
465                 470                 475                 480 


Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg 
                485                 490                 495     


Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg 
            500                 505                 510         


Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val 
        515                 520                 525             


Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu 
    530                 535                 540                 


Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn 
545                 550                 555                 560 


Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val 
                565                 570                 575     


Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro 
            580                 585                 590         


Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu 
        595                 600                 605             


Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys 
    610                 615                 620                 


Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly 
625                 630                 635                 640 


Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg 
                645                 650                 655     


Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu 
            660                 665                 670         


Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala 
        675                 680                 685             


Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe 
    690                 695                 700                 


Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser 
705                 710                 715                 720 


Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr 
                725                 730                 735     


Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro 
            740                 745                 750         


<210> 7
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
gtgaacacac aggctaaggc tccaatcta                                         29


<210> 8
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
tcaacaagca aaggacagac atcccac                                           27


<210> 9
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
agcagagggg caggctgggt ctctc                                             25


<210> 10
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
aggaacacag ttgttgggct ggggttgtc                                         29


<210> 11
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
tatcttctcg agttctctag cctccaatcc tggg                                   34


<210> 12
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
cacatagaat tcgtcccctt gcacagcgta atgg                                   34


<210> 13
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
agcagagggg caggctgggt ctctc                                             25


<210> 14
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
cacatagaat tcgtcccctt gcacagcgta atgg                                   34


<210> 15
<211> 164
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
gctagcgtta acaccggtat ggaattcgaa caaaaactca tctcagaaga ggatctggat       60

atccctgcag gctaaggatc ccacgtgctc gagcgtctcc aattggcggc cgcaagagga      120

tcgcatcacc atcaccatca ctagagtgaa gcttaagttt aaac                       164


<210> 16
<211> 66
<212> PRT
<213> Homo sapiens

<400> 16
Thr Arg Lys Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr 
1               5                   10                  15      


Cys Phe Pro Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala 
            20                  25                  30          


Pro His His Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser 
        35                  40                  45              


Leu Asn Asn Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg 
    50                  55                  60                  


Lys Pro 
65      


<210> 17
<211> 33
<212> PRT
<213> Homo sapiens

<400> 17
Thr Arg Lys Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr 
1               5                   10                  15      


Cys Phe Pro Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala 
            20                  25                  30          


Pro 
    


<210> 18
<211> 21
<212> PRT
<213> Homo sapiens

<400> 18
Pro Ile Ser Leu Asn Asn Leu Glu Leu Gln Asp Leu Met His Ile Ser 
1               5                   10                  15      


Arg Ala Arg Lys Pro 
            20      


