                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  INHIBITORS OF ALK AND SRPK AND METHODS OF USE

<130>  DFCI-123/001WO 322270-2601

<150>  US 62/222,504
<151>  2015-09-23

<150>  US 62/356,066
<151>  2016-06-29

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Arg Lys Val Leu Ala Leu Gln Ala Arg Lys Lys Arg Thr Lys 
1               5                   10                  15      


Ala Lys Lys Asp Lys Ala Gln Arg Lys Ser Glu Thr Gln His Arg Gly 
            20                  25                  30          


Ser Ala Pro His Ser Glu Ser Asp Leu Pro Glu Gln Glu Glu Glu Ile 
        35                  40                  45              


Leu Gly Ser Asp Asp Asp Glu Gln Glu Asp Pro Asn Asp Tyr Cys Lys 
    50                  55                  60                  


Gly Gly Tyr His Leu Val Lys Ile Gly Asp Leu Phe Asn Gly Arg Tyr 
65                  70                  75                  80  


His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp Leu 
                85                  90                  95      


Ser Trp Asp Ile Gln Gly Lys Lys Phe Val Ala Met Lys Val Val Lys 
            100                 105                 110         


Ser Ala Glu His Tyr Thr Glu Thr Ala Leu Asp Glu Ile Arg Leu Leu 
        115                 120                 125             


Lys Ser Val Arg Asn Ser Asp Pro Asn Asp Pro Asn Arg Glu Met Val 
    130                 135                 140                 


Val Gln Leu Leu Asp Asp Phe Lys Ile Ser Gly Val Asn Gly Thr His 
145                 150                 155                 160 


Ile Cys Met Val Phe Glu Val Leu Gly His His Leu Leu Lys Trp Ile 
                165                 170                 175     


Ile Lys Ser Asn Tyr Gln Gly Leu Pro Leu Pro Cys Val Lys Lys Ile 
            180                 185                 190         


Ile Gln Gln Val Leu Gln Gly Leu Asp Tyr Leu His Thr Lys Cys Arg 
        195                 200                 205             


Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Leu Ser Val Asn 
    210                 215                 220                 


Glu Gln Tyr Ile Arg Arg Leu Ala Ala Glu Ala Thr Glu Trp Gln Arg 
225                 230                 235                 240 


Ser Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro Gln 
                245                 250                 255     


Pro Lys Pro Ala Asp Lys Met Ser Lys Asn Lys Lys Lys Lys Leu Lys 
            260                 265                 270         


Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg Met Gln Glu 
        275                 280                 285             


Ile Glu Glu Met Glu Lys Glu Ser Gly Pro Gly Gln Lys Arg Pro Asn 
    290                 295                 300                 


Lys Gln Glu Glu Ser Glu Ser Pro Val Glu Arg Pro Leu Lys Glu Asn 
305                 310                 315                 320 


Pro Pro Asn Lys Met Thr Gln Glu Lys Leu Glu Glu Ser Ser Thr Ile 
                325                 330                 335     


Gly Gln Asp Gln Thr Leu Met Glu Arg Asp Thr Glu Gly Gly Ala Ala 
            340                 345                 350         


Glu Ile Asn Cys Asn Gly Val Ile Glu Val Ile Asn Tyr Thr Gln Asn 
        355                 360                 365             


Ser Asn Asn Glu Thr Leu Arg His Lys Glu Asp Leu His Asn Ala Asn 
    370                 375                 380                 


Asp Cys Asp Val Gln Asn Leu Asn Gln Glu Ser Ser Phe Leu Ser Ser 
385                 390                 395                 400 


Gln Asn Gly Asp Ser Ser Thr Ser Gln Glu Thr Asp Ser Cys Thr Pro 
                405                 410                 415     


Ile Thr Ser Glu Val Ser Asp Thr Met Val Cys Gln Ser Ser Ser Thr 
            420                 425                 430         


Val Gly Gln Ser Phe Ser Glu Gln His Ile Ser Gln Leu Gln Glu Ser 
        435                 440                 445             


Ile Arg Ala Glu Ile Pro Cys Glu Asp Glu Gln Glu Gln Glu His Asn 
    450                 455                 460                 


Gly Pro Leu Asp Asn Lys Gly Lys Ser Thr Ala Gly Asn Phe Leu Val 
465                 470                 475                 480 


Asn Pro Leu Glu Pro Lys Asn Ala Glu Lys Leu Lys Val Lys Ile Ala 
                485                 490                 495     


Asp Leu Gly Asn Ala Cys Trp Val His Lys His Phe Thr Glu Asp Ile 
            500                 505                 510         


Gln Thr Arg Gln Tyr Arg Ser Leu Glu Val Leu Ile Gly Ser Gly Tyr 
        515                 520                 525             


Asn Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met Ala Phe Glu Leu 
    530                 535                 540                 


Ala Thr Gly Asp Tyr Leu Phe Glu Pro His Ser Gly Glu Glu Tyr Thr 
545                 550                 555                 560 


Arg Asp Glu Asp His Ile Ala Leu Ile Ile Glu Leu Leu Gly Lys Val 
                565                 570                 575     


Pro Arg Lys Leu Ile Val Ala Gly Lys Tyr Ser Lys Glu Phe Phe Thr 
            580                 585                 590         


Lys Lys Gly Asp Leu Lys His Ile Thr Lys Leu Lys Pro Trp Gly Leu 
        595                 600                 605             


Phe Glu Val Leu Val Glu Lys Tyr Glu Trp Ser Gln Glu Glu Ala Ala 
    610                 615                 620                 


Gly Phe Thr Asp Phe Leu Leu Pro Met Leu Glu Leu Ile Pro Glu Lys 
625                 630                 635                 640 


Arg Ala Thr Ala Ala Glu Cys Leu Arg His Pro Trp Leu Asn Ser 
                645                 650                 655 


