                         SEQUENCE LISTING

<110>  Vitality Biopharma, Inc.
 
<120>  TBD

<130>  3334-103DR

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  458
<212>  PRT
<213>  Stevia rebaudiana

<400>  1

Met Glu Asn Lys Thr Glu Thr Thr Val Arg Arg Arg Arg Arg Ile Ile 
1               5                   10                  15      


Leu Phe Pro Val Pro Phe Gln Gly His Ile Asn Pro Ile Leu Gln Leu 
            20                  25                  30          


Ala Asn Val Leu Tyr Ser Lys Gly Phe Ser Ile Thr Ile Phe His Thr 
        35                  40                  45              


Asn Phe Asn Lys Pro Lys Thr Ser Asn Tyr Pro His Phe Thr Phe Arg 
    50                  55                  60                  


Phe Ile Leu Asp Asn Asp Pro Gln Asp Glu Arg Ile Ser Asn Leu Pro 
65                  70                  75                  80  


Thr His Gly Pro Leu Ala Gly Met Arg Ile Pro Ile Ile Asn Glu His 
                85                  90                  95      


Gly Ala Asp Glu Leu Arg Arg Glu Leu Glu Leu Leu Met Leu Ala Ser 
            100                 105                 110         


Glu Glu Asp Glu Glu Val Ser Cys Leu Ile Thr Asp Ala Leu Trp Tyr 
        115                 120                 125             


Phe Ala Gln Ser Val Ala Asp Ser Leu Asn Leu Arg Arg Leu Val Leu 
    130                 135                 140                 


Met Thr Ser Ser Leu Phe Asn Phe His Ala His Val Ser Leu Pro Gln 
145                 150                 155                 160 


Phe Asp Glu Leu Gly Tyr Leu Asp Pro Asp Asp Lys Thr Arg Leu Glu 
                165                 170                 175     


Glu Gln Ala Ser Gly Phe Pro Met Leu Lys Val Lys Asp Ile Lys Ser 
            180                 185                 190         


Ala Tyr Ser Asn Trp Gln Ile Leu Lys Glu Ile Leu Gly Lys Met Ile 
        195                 200                 205             


Lys Gln Thr Lys Ala Ser Ser Gly Val Ile Trp Asn Ser Phe Lys Glu 
    210                 215                 220                 


Leu Glu Glu Ser Glu Leu Glu Thr Val Ile Arg Glu Ile Pro Ala Pro 
225                 230                 235                 240 


Ser Phe Leu Ile Pro Leu Pro Lys His Leu Thr Ala Ser Ser Ser Ser 
                245                 250                 255     


Leu Leu Asp His Asp Arg Thr Val Phe Gln Trp Leu Asp Gln Gln Pro 
            260                 265                 270         


Pro Ser Ser Val Leu Tyr Val Ser Phe Gly Ser Thr Ser Glu Val Asp 
        275                 280                 285             


Glu Lys Asp Phe Leu Glu Ile Ala Arg Gly Leu Val Asp Ser Lys Gln 
    290                 295                 300                 


Ser Phe Leu Trp Val Val Arg Pro Gly Phe Val Lys Gly Ser Thr Trp 
305                 310                 315                 320 


Val Glu Pro Leu Pro Asp Gly Phe Leu Gly Glu Arg Gly Arg Ile Val 
                325                 330                 335     


Lys Trp Val Pro Gln Gln Glu Val Leu Ala His Gly Ala Ile Gly Ala 
            340                 345                 350         


Phe Trp Thr His Ser Gly Trp Asn Ser Thr Leu Glu Ser Val Cys Glu 
        355                 360                 365             


Gly Val Pro Met Ile Phe Ser Asp Phe Gly Leu Asp Gln Pro Leu Asn 
    370                 375                 380                 


Ala Arg Tyr Met Ser Asp Val Leu Lys Val Gly Val Tyr Leu Glu Asn 
385                 390                 395                 400 


Gly Trp Glu Arg Gly Glu Ile Ala Asn Ala Ile Arg Arg Val Met Val 
                405                 410                 415     


Asp Glu Glu Gly Glu Tyr Ile Arg Gln Asn Ala Arg Val Leu Lys Gln 
            420                 425                 430         


Lys Ala Asp Val Ser Leu Met Lys Gly Gly Ser Ser Tyr Glu Ser Leu 
        435                 440                 445             


Glu Ser Leu Val Ser Tyr Ile Ser Ser Leu 
    450                 455             


<210>  2
<211>  1377
<212>  DNA
<213>  Stevia rebaudiana

<400>  2
atggaaaata aaacggagac caccgttcgc cggcgccgga gaataatatt attcccggta       60

ccatttcaag gccacattaa cccaattctt cagctagcca atgtgttgta ctctaaagga      120

ttcagtatca ccatctttca caccaacttc aacaaaccca aaacatctaa ttaccctcac      180

ttcactttca gattcatcct cgacaacgac ccacaagacg aacgcatttc caatctaccg      240

actcatggtc cgctcgctgg tatgcggatt ccgattatca acgaacacgg agctgacgaa      300

ttacgacgcg aactggaact gttgatgtta gcttctgaag aagatgaaga ggtatcgtgt      360

ttaatcacgg atgctctttg gtacttcgcg caatctgttg ctgacagtct taacctccga      420

cggcttgttt tgatgacaag cagcttgttt aattttcatg cacatgtttc acttcctcag      480

tttgatgagc ttggttacct cgatcctgat gacaaaaccc gtttggaaga acaagcgagt      540

gggtttccta tgctaaaagt gaaagacatc aagtctgcgt attcgaactg gcaaatactc      600

aaagagatat tagggaagat gataaaacaa acaagagcat cttcaggagt catctggaac      660

tcatttaagg aactcgaaga gtctgagctc gaaactgtta tccgtgagat cccggctcca      720

agtttcttga taccactccc caagcatttg acagcctctt ccagcagctt actagaccac      780

gatcgaaccg tttttcaatg gttagaccaa caaccgccaa gttcggtact gtatgttagt      840

tttggtagta ctagtgaagt ggatgagaaa gatttcttgg aaatagctcg tgggttggtt      900

gatagcaagc agtcgttttt atgggtggtt cgacctgggt ttgtcaaggg ttcgacgtgg      960

gtcgaaccgt tgccagatgg gttcttgggt gaaagaggac gtattgtgaa atgggttcca     1020

cagcaagaag tgctagctca tggagcaata ggcgcattct ggactcatag cggatggaac     1080

tctacgttgg aaagcgtttg tgaaggtgtt cctatgattt tctcggattt tgggctcgat     1140

caaccgttga atgctagata catgagtgat gttttgaagg taggggtgta tttggaaaat     1200

gggtgggaaa gaggagagat agcaaatgca ataagaagag ttatggtgga tgaagaagga     1260

gaatacatta gacagaatgc aagagttttg aaacaaaagg cagatgtttc tttgatgaag     1320

ggtggttcgt cttacgaatc attagagtct ctagtttctt acatttcatc gttgtaa        1377


<210>  3
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGT76G1 with a 6x Histidine tag at the N-terminus

<400>  3

Met His His His His His His Gly Ser Gly Glu Asn Lys Thr Glu Thr 
1               5                   10                  15      


Thr Val Arg Arg Arg Arg Arg Ile Ile Leu Phe Pro Val Pro Phe Gln 
            20                  25                  30          


Gly His Ile Asn Pro Ile Leu Gln Leu Ala Asn Val Leu Tyr Ser Lys 
        35                  40                  45              


Gly Phe Ser Ile Thr Ile Phe His Thr Asn Phe Asn Lys Pro Lys Thr 
    50                  55                  60                  


Ser Asn Tyr Pro His Phe Thr Phe Arg Phe Ile Leu Asp Asn Asp Pro 
65                  70                  75                  80  


Gln Asp Glu Arg Ile Ser Asn Leu Pro Thr His Gly Pro Leu Ala Gly 
                85                  90                  95      


Met Arg Ile Pro Ile Ile Asn Glu His Gly Ala Asp Glu Leu Arg Arg 
            100                 105                 110         


Glu Leu Glu Leu Leu Met Leu Ala Ser Glu Glu Asp Glu Glu Val Ser 
        115                 120                 125             


Cys Leu Ile Thr Asp Ala Leu Trp Tyr Phe Ala Gln Ser Val Ala Asp 
    130                 135                 140                 


Ser Leu Asn Leu Arg Arg Leu Val Leu Met Thr Ser Ser Leu Phe Asn 
145                 150                 155                 160 


Phe His Ala His Val Ser Leu Pro Gln Phe Asp Glu Leu Gly Tyr Leu 
                165                 170                 175     


Asp Pro Asp Asp Lys Thr Arg Leu Glu Glu Gln Ala Ser Gly Phe Pro 
            180                 185                 190         


Met Leu Lys Val Lys Asp Ile Lys Ser Ala Tyr Ser Asn Trp Gln Ile 
        195                 200                 205             


Leu Lys Glu Ile Leu Gly Lys Met Ile Lys Gln Thr Lys Ala Ser Ser 
    210                 215                 220                 


Gly Val Ile Trp Asn Ser Phe Lys Glu Leu Glu Glu Ser Glu Leu Glu 
225                 230                 235                 240 


Thr Val Ile Arg Glu Ile Pro Ala Pro Ser Phe Leu Ile Pro Leu Pro 
                245                 250                 255     


Lys His Leu Thr Ala Ser Ser Ser Ser Leu Leu Asp His Asp Arg Thr 
            260                 265                 270         


Val Phe Gln Trp Leu Asp Gln Gln Pro Pro Ser Ser Val Leu Tyr Val 
        275                 280                 285             


Ser Phe Gly Ser Thr Ser Glu Val Asp Glu Lys Asp Phe Leu Glu Ile 
    290                 295                 300                 


Ala Arg Gly Leu Val Asp Ser Lys Gln Ser Phe Leu Trp Val Val Arg 
305                 310                 315                 320 


Pro Gly Phe Val Lys Gly Ser Thr Trp Val Glu Pro Leu Pro Asp Gly 
                325                 330                 335     


Phe Leu Gly Glu Arg Gly Arg Ile Val Lys Trp Val Pro Gln Gln Glu 
            340                 345                 350         


Val Leu Ala His Gly Ala Ile Gly Ala Phe Trp Thr His Ser Gly Trp 
        355                 360                 365             


Asn Ser Thr Leu Glu Ser Val Cys Glu Gly Val Pro Met Ile Phe Ser 
    370                 375                 380                 


Asp Phe Gly Leu Asp Gln Pro Leu Asn Ala Arg Tyr Met Ser Asp Val 
385                 390                 395                 400 


Leu Lys Val Gly Val Tyr Leu Glu Asn Gly Trp Glu Arg Gly Glu Ile 
                405                 410                 415     


Ala Asn Ala Ile Arg Arg Val Met Val Asp Glu Glu Gly Glu Tyr Ile 
            420                 425                 430         


Arg Gln Asn Ala Arg Val Leu Lys Gln Lys Ala Asp Val Ser Leu Met 
        435                 440                 445             


Lys Gly Gly Ser Ser Tyr Glu Ser Leu Glu Ser Leu Val Ser Tyr Ile 
    450                 455                 460                 


Ser Ser Leu 
465         


<210>  4
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding SEQ ID NO:3 codon optimized for expression in Pichia pastoris

<400>  4
atgcaccacc atcaccacca tggttctggt gaaaacaaaa ctgaaactac tgttagaaga       60

agaagaagaa tcattttgtt tccagtacca tttcaaggcc atatcaatcc aattcttcaa      120

ttggccaatg ttttgtactc caaaggattc tccatcacca tttttcacac caatttcaac      180

aaaccaaaga cttccaacta tcctcacttc actttcagat ttattttgga taatgatcct      240

caagatgaaa gaatttccaa tcttccgact catggtcctt tggctggtat gagaattcca      300

atcatcaatg aacatggtgc tgatgaatta agaagagaat tggaactttt gatgttggct      360

tctgaagaag atgaagaagt ttcatgttta atcactgatg ctttatggta ttttgctcaa      420

tctgttgctg attctttgaa tttgcgacgg ttggttttga tgacttcttc tttgttcaac      480

tttcatgctc atgtttcttt acctcagttt gatgaacttg gatatttgga tccagatgac      540

aaaactagat tggaagaaca agctagtggg tttcctatgt tgaaagtcaa agatatcaaa      600

tctgcttact ccaactggca aattctcaaa gaaattttgg gaaaaatgat caaacaaaca      660

aaagcttctt ctggagtcat ttggaactca ttcaaagaat tggaagaatc tgaattggaa      720

actgttatta gagaaattcc tgctccaagt tttttgattc ctttgccaaa acatttgact      780

gcttcttctt cttctttatt ggatcacgat agaactgttt ttcaatggtt agatcaacaa      840

cctccatctt ctgttttgta tgttagtttt ggatctactt ctgaagttga tgaaaaagat      900

tttttggaaa ttgctagagg tttggttgat tccaaacaaa gttttttatg ggttgttaga      960

ccaggatttg tcaaaggatc tacttgggtc gaacctttgc cagatggatt tttgggagaa     1020

agaggaagaa ttgtcaaatg ggttccacag caagaagttt tggctcatgg tgctattggt     1080

gctttttgga ctcattctgg atggaactct actttggaat ctgtttgtga aggtgttcca     1140

atgatttttt ctgattttgg tttggatcaa ccattgaatg ctagatacat gtctgatgtt     1200

ttgaaagttg gtgtttattt ggaaaatggg tgggaaagag gtgaaattgc caatgctatt     1260

agaagagtca tggttgatga agaaggagaa tacattagac aaaatgctag agttttgaaa     1320

caaaaagctg atgtttcttt gatgaagggt ggatcttctt atgaatcttt ggaatctttg     1380

gtttcttaca tttcttctct ttaa                                            1404


<210>  5
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGT76G1 with a 6x Histidine-Glutamine tag at the N-terminus

<400>  5

Met His Gln His Gln His Gln Ser Gly Ser Met Glu Asn Lys Thr Glu 
1               5                   10                  15      


Thr Thr Val Arg Arg Arg Arg Arg Ile Ile Leu Phe Pro Val Pro Phe 
            20                  25                  30          


Gln Gly His Ile Asn Pro Ile Leu Gln Leu Ala Asn Val Leu Tyr Ser 
        35                  40                  45              


Lys Gly Phe Ser Ile Thr Ile Phe His Thr Asn Phe Asn Lys Pro Lys 
    50                  55                  60                  


Thr Ser Asn Tyr Pro His Phe Thr Phe Arg Phe Ile Leu Asp Asn Asp 
65                  70                  75                  80  


Pro Gln Asp Glu Arg Ile Ser Asn Leu Pro Thr His Gly Pro Leu Ala 
                85                  90                  95      


Gly Met Arg Ile Pro Ile Ile Asn Glu His Gly Ala Asp Glu Leu Arg 
            100                 105                 110         


Arg Glu Leu Glu Leu Leu Met Leu Ala Ser Glu Glu Asp Glu Glu Val 
        115                 120                 125             


Ser Cys Leu Ile Thr Asp Ala Leu Trp Tyr Phe Ala Gln Ser Val Ala 
    130                 135                 140                 


Asp Ser Leu Asn Leu Arg Arg Leu Val Leu Met Thr Ser Ser Leu Phe 
145                 150                 155                 160 


Asn Phe His Ala His Val Ser Leu Pro Gln Phe Asp Glu Leu Gly Tyr 
                165                 170                 175     


Leu Asp Pro Asp Asp Lys Thr Arg Leu Glu Glu Gln Ala Ser Gly Phe 
            180                 185                 190         


Pro Met Leu Lys Val Lys Asp Ile Lys Ser Ala Tyr Ser Asn Trp Gln 
        195                 200                 205             


Ile Leu Lys Glu Ile Leu Gly Lys Met Ile Lys Gln Thr Lys Ala Ser 
    210                 215                 220                 


Ser Gly Val Ile Trp Asn Ser Phe Lys Glu Leu Glu Glu Ser Glu Leu 
225                 230                 235                 240 


Glu Thr Val Ile Arg Glu Ile Pro Ala Pro Ser Phe Leu Ile Pro Leu 
                245                 250                 255     


Pro Lys His Leu Thr Ala Ser Ser Ser Ser Leu Leu Asp His Asp Arg 
            260                 265                 270         


Thr Val Phe Gln Trp Leu Asp Gln Gln Pro Pro Ser Ser Val Leu Tyr 
        275                 280                 285             


Val Ser Phe Gly Ser Thr Ser Glu Val Asp Glu Lys Asp Phe Leu Glu 
    290                 295                 300                 


Ile Ala Arg Gly Leu Val Asp Ser Lys Gln Ser Phe Leu Trp Val Val 
305                 310                 315                 320 


Arg Pro Gly Phe Val Lys Gly Ser Thr Trp Val Glu Pro Leu Pro Asp 
                325                 330                 335     


Gly Phe Leu Gly Glu Arg Gly Arg Ile Val Lys Trp Val Pro Gln Gln 
            340                 345                 350         


Glu Val Leu Ala His Gly Ala Ile Gly Ala Phe Trp Thr His Ser Gly 
        355                 360                 365             


Trp Asn Ser Thr Leu Glu Ser Val Cys Glu Gly Val Pro Met Ile Phe 
    370                 375                 380                 


Ser Asp Phe Gly Leu Asp Gln Pro Leu Asn Ala Arg Tyr Met Ser Asp 
385                 390                 395                 400 


Val Leu Lys Val Gly Val Tyr Leu Glu Asn Gly Trp Glu Arg Gly Glu 
                405                 410                 415     


Ile Ala Asn Ala Ile Arg Arg Val Met Val Asp Glu Glu Gly Glu Tyr 
            420                 425                 430         


Ile Arg Gln Asn Ala Arg Val Leu Lys Gln Lys Ala Asp Val Ser Leu 
        435                 440                 445             


Met Lys Gly Gly Ser Ser Tyr Glu Ser Leu Glu Ser Leu Val Ser Tyr 
    450                 455                 460                 


Ile Ser Ser Leu 
465             


<210>  6
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding SEQ ID NO:5 codon optimized for 
       expression in Pichia pastoris

<400>  6
atgcatcaac atcaacacca atctggatct atggagaaca agaccgagac tacagttaga       60

agaagaagaa gaataatcct gtttccagta ccattccaag gacacatcaa cccaatcttg      120

cagttagcaa atgtacttta ttctaaaggc tttagtatta cgatttttca cactaatttt      180

aataagccaa aaacatccaa ttaccctcac ttcacattca gatttatctt ggataacgat      240

cctcaagatg aacgtatctc caacctgcca acacatggac cattggccgg tatgcgtatt      300

cctataatca acgagcatgg tgctgatgag cttagacgtg aactggaact gttgatgctg      360

gcatcggagg aagatgaaga ggttagttgc ttgataacgg atgccctctg gtatttcgca      420

caatcagtcg ctgactcctt gaaccttagg agattggtat tgatgactag ttcgttgttc      480

aacttccatg cccatgtttc tttgcctcaa tttgatgagc tgggttattt ggatcctgac      540

gataagactc gtttagaaga acaggcgtca ggcttcccca tgttaaaggt taaagatatt      600

aagtccgcct attctaactg gcaaattctc aaagagattc tagggaaaat gattaaacaa      660

accaaggcct cttcaggagt aatctggaac agtttcaaag aactagaaga atccgagttg      720

gaaactgtta ttcgtgaaat ccctgctcca tctttcctta tcccattacc aaagcacctc      780

actgcctcct ctagttctct tctggaccat gatagaacag tctttcagtg gctcgatcag      840

caacctccat cttctgtctt gtacgttagt tttggttcca cctcggaagt agatgaaaaa      900

gactttctgg aaattgctcg aggactagtt gactccaagc aatcctttct gtgggttgtt      960

agacctggat tcgtaaaagg atccacctgg gtagaacccc tcccagatgg atttttgggc     1020

gaaaggggaa gaattgttaa atgggtgcct caacaagaag ttttagctca tggggccatt     1080

ggagcttttt ggactcatag tggatggaat tctaccttag aatctgtttg tgaaggagtt     1140

ccaatgattt tttctgattt tggattggat cagcctctta atgccagata tatgtccgat     1200

gtcctcaagg tcggagtgta cctggaaaat ggttgggaga gaggtgagat tgcaaatgct     1260

atacgtagag tcatggttga tgaagagggc gagtatatta gacaaaacgc tagagtgcta     1320

aagcagaagg ccgatgtttc ccttatgaag gggggaagtt catatgagag tttggaatcc     1380

ctagtgtcct acatttcttc gctataa                                         1407


<210>  7
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGT76G1 with a 6x Histidine tag at the C-terminus

<400>  7

Met Glu Asn Lys Thr Glu Thr Thr Val Arg Arg Arg Arg Arg Ile Ile 
1               5                   10                  15      


Leu Phe Pro Val Pro Phe Gln Gly His Ile Asn Pro Ile Leu Gln Leu 
            20                  25                  30          


Ala Asn Val Leu Tyr Ser Lys Gly Phe Ser Ile Thr Ile Phe His Thr 
        35                  40                  45              


Asn Phe Asn Lys Pro Lys Thr Ser Asn Tyr Pro His Phe Thr Phe Arg 
    50                  55                  60                  


Phe Ile Leu Asp Asn Asp Pro Gln Asp Glu Arg Ile Ser Asn Leu Pro 
65                  70                  75                  80  


Thr His Gly Pro Leu Ala Gly Met Arg Ile Pro Ile Ile Asn Glu His 
                85                  90                  95      


Gly Ala Asp Glu Leu Arg Arg Glu Leu Glu Leu Leu Met Leu Ala Ser 
            100                 105                 110         


Glu Glu Asp Glu Glu Val Ser Cys Leu Ile Thr Asp Ala Leu Trp Tyr 
        115                 120                 125             


Phe Ala Gln Ser Val Ala Asp Ser Leu Asn Leu Arg Arg Leu Val Leu 
    130                 135                 140                 


Met Thr Ser Ser Leu Phe Asn Phe His Ala His Val Ser Leu Pro Gln 
145                 150                 155                 160 


Phe Asp Glu Leu Gly Tyr Leu Asp Pro Asp Asp Lys Thr Arg Leu Glu 
                165                 170                 175     


Glu Gln Ala Ser Gly Phe Pro Met Leu Lys Val Lys Asp Ile Lys Ser 
            180                 185                 190         


Ala Tyr Ser Asn Trp Gln Ile Leu Lys Glu Ile Leu Gly Lys Met Ile 
        195                 200                 205             


Lys Gln Thr Arg Ala Ser Ser Gly Val Ile Trp Asn Ser Phe Lys Glu 
    210                 215                 220                 


Leu Glu Glu Ser Glu Leu Glu Thr Val Ile Arg Glu Ile Pro Ala Pro 
225                 230                 235                 240 


Ser Phe Leu Ile Pro Leu Pro Lys His Leu Thr Ala Ser Ser Ser Ser 
                245                 250                 255     


Leu Leu Asp His Asp Arg Thr Val Phe Gln Trp Leu Asp Gln Gln Pro 
            260                 265                 270         


Pro Ser Ser Val Leu Tyr Val Ser Phe Gly Ser Thr Ser Glu Val Asp 
        275                 280                 285             


Glu Lys Asp Phe Leu Glu Ile Ala Arg Gly Leu Val Asp Ser Lys Gln 
    290                 295                 300                 


Ser Phe Leu Trp Val Val Arg Pro Gly Phe Val Lys Gly Ser Thr Trp 
305                 310                 315                 320 


Val Glu Pro Leu Pro Asp Gly Phe Leu Gly Glu Arg Gly Arg Ile Val 
                325                 330                 335     


Lys Trp Val Pro Gln Gln Glu Val Leu Ala His Gly Ala Ile Gly Ala 
            340                 345                 350         


Phe Trp Thr His Ser Gly Trp Asn Ser Thr Leu Glu Ser Val Cys Glu 
        355                 360                 365             


Gly Val Pro Met Ile Phe Ser Asp Phe Gly Leu Asp Gln Pro Leu Asn 
    370                 375                 380                 


Ala Arg Tyr Met Ser Asp Val Leu Lys Val Gly Val Tyr Leu Glu Asn 
385                 390                 395                 400 


Gly Trp Glu Arg Gly Glu Ile Ala Asn Ala Ile Arg Arg Val Met Val 
                405                 410                 415     


Asp Glu Glu Gly Glu Tyr Ile Arg Gln Asn Ala Arg Val Leu Lys Gln 
            420                 425                 430         


Lys Ala Asp Val Ser Leu Met Lys Gly Gly Ser Ser Tyr Glu Ser Leu 
        435                 440                 445             


Glu Ser Leu Val Ser Tyr Ile Ser Ser Leu Gly Ser His His His His 
    450                 455                 460                 


His His 
465     


<210>  8
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding SEQ ID NO:7 codon optimized for 
       expression in Escherichia coli

<400>  8
atggaaaata aaaccgaaac caccgtccgt cgccgtcgtc gtatcattct gttcccggtc       60

ccgttccaag gtcacatcaa cccgattctg cagctggcca acgtgctgta tagcaaaggt      120

ttctctatca ccatcttcca tacgaacttc aacaaaccga aaacctctaa ctacccgcac      180

tttacgttcc gttttattct ggataacgac ccgcaggatg aacgcatcag taatctgccg      240

acccatggtc cgctggcggg tatgcgtatt ccgattatca acgaacacgg cgcagatgaa      300

ctgcgtcgcg aactggaact gctgatgctg gcctctgaag aagatgaaga agttagttgc      360

ctgatcaccg acgcactgtg gtattttgcc cagagtgttg cagattccct gaacctgcgt      420

cgcctggtcc tgatgacgag ctctctgttc aattttcatg cccacgtttc cctgccgcag      480

ttcgatgaac tgggttatct ggacccggat gacaaaaccc gcctggaaga acaagcttca      540

ggctttccga tgctgaaagt caaagatatt aaaagtgcgt actccaactg gcagattctg      600

aaagaaatcc tgggtaaaat gatcaaacaa acccgtgcaa gttccggcgt catctggaat      660

tccttcaaag aactggaaga atcagaactg gaaacggtga ttcgcgaaat cccggctccg      720

tcttttctga ttccgctgcc gaaacatctg accgcgtcat cgagctctct gctggatcac      780

gaccgtacgg tgtttcagtg gctggatcag caaccgccga gttccgtgct gtacgttagc      840

ttcggtagca cctctgaagt ggatgaaaaa gactttctgg aaatcgctcg tggcctggtt      900

gattcaaaac aatcgttcct gtgggtggtt cgcccgggtt ttgtgaaagg cagcacgtgg      960

gttgaaccgc tgccggatgg cttcctgggt gaacgtggtc gcattgtcaa atgggtgccg     1020

cagcaagaag tgctggcaca tggtgctatc ggcgcgtttt ggacccactc aggttggaac     1080

tcgacgctgg aaagcgtttg tgaaggtgtc ccgatgattt tctcggattt tggcctggac     1140

cagccgctga atgcacgtta tatgagcgat gttctgaaag tcggtgtgta cctggaaaac     1200

ggttgggaac gcggcgaaat tgcgaatgcc atccgtcgcg ttatggtcga tgaagaaggc     1260

gaatatatcc gtcagaatgc tcgcgtcctg aaacaaaaag cggacgttag tctgatgaaa     1320

ggcggttcat cgtacgaatc cctggaatca ctggtctcct acatttcttc tctgggctcg     1380

catcatcatc atcatcatta a                                               1401


<210>  9
<211>  472
<212>  PRT
<213>  Oryza sativa 

<400>  9

Met His Gln His Gln His Gln Ser Gly Ser Met Asp Ser Gly Tyr Ser 
1               5                   10                  15      


Ser Ser Tyr Ala Ala Ala Ala Gly Met His Val Val Ile Cys Pro Trp 
            20                  25                  30          


Leu Ala Phe Gly His Leu Leu Pro Cys Leu Asp Leu Ala Gln Arg Leu 
        35                  40                  45              


Ala Ser Arg Gly His Arg Val Ser Phe Val Ser Thr Pro Arg Asn Ile 
    50                  55                  60                  


Ser Arg Leu Pro Pro Val Arg Pro Ala Leu Ala Pro Leu Val Ala Phe 
65                  70                  75                  80  


Val Ala Leu Pro Leu Pro Arg Val Glu Gly Leu Pro Asp Gly Ala Glu 
                85                  90                  95      


Ser Thr Asn Asp Val Pro His Asp Arg Pro Asp Met Val Glu Leu His 
            100                 105                 110         


Arg Arg Ala Phe Asp Gly Leu Ala Ala Pro Phe Ser Glu Phe Leu Gly 
        115                 120                 125             


Thr Ala Cys Ala Asp Trp Val Ile Val Asp Val Phe His His Trp Ala 
    130                 135                 140                 


Ala Ala Ala Ala Leu Glu His Lys Val Pro Cys Ala Met Met Leu Leu 
145                 150                 155                 160 


Gly Ser Ala His Met Ile Ala Ser Ile Ala Asp Arg Arg Leu Glu Arg 
                165                 170                 175     


Ala Glu Thr Glu Ser Pro Ala Ala Ala Gly Gln Gly Arg Pro Ala Ala 
            180                 185                 190         


Ala Pro Thr Phe Glu Val Ala Arg Met Lys Leu Ile Arg Thr Lys Gly 
        195                 200                 205             


Ser Ser Gly Met Ser Leu Ala Glu Arg Phe Ser Leu Thr Leu Ser Arg 
    210                 215                 220                 


Ser Ser Leu Val Val Gly Arg Ser Cys Val Glu Phe Glu Pro Glu Thr 
225                 230                 235                 240 


Val Pro Leu Leu Ser Thr Leu Arg Gly Lys Pro Ile Thr Phe Leu Gly 
                245                 250                 255     


Leu Met Pro Pro Leu His Glu Gly Arg Arg Glu Asp Gly Glu Asp Ala 
            260                 265                 270         


Thr Val Arg Trp Leu Asp Ala Gln Pro Ala Lys Ser Val Val Tyr Val 
        275                 280                 285             


Ala Leu Gly Ser Glu Val Pro Leu Gly Val Glu Lys Val His Glu Leu 
    290                 295                 300                 


Ala Leu Gly Leu Glu Leu Ala Gly Thr Arg Phe Leu Trp Ala Leu Arg 
305                 310                 315                 320 


Lys Pro Thr Gly Val Ser Asp Ala Asp Leu Leu Pro Ala Gly Phe Glu 
                325                 330                 335     


Glu Arg Thr Arg Gly Arg Gly Val Val Ala Thr Arg Trp Val Pro Gln 
            340                 345                 350         


Met Ser Ile Leu Ala His Ala Ala Val Gly Ala Phe Leu Thr His Cys 
        355                 360                 365             


Gly Trp Asn Ser Thr Ile Glu Gly Leu Met Phe Gly His Pro Leu Ile 
    370                 375                 380                 


Met Leu Pro Ile Phe Gly Asp Gln Gly Pro Asn Ala Arg Leu Ile Glu 
385                 390                 395                 400 


Ala Lys Asn Ala Gly Leu Gln Val Ala Arg Asn Asp Gly Asp Gly Ser 
                405                 410                 415     


Phe Asp Arg Glu Gly Val Ala Ala Ala Ile Arg Ala Val Ala Val Glu 
            420                 425                 430         


Glu Glu Ser Ser Lys Val Phe Gln Ala Lys Ala Lys Lys Leu Gln Glu 
        435                 440                 445             


Ile Val Ala Asp Met Ala Cys His Glu Arg Tyr Ile Asp Gly Phe Ile 
    450                 455                 460                 


Gln Gln Leu Arg Ser Tyr Lys Asp 
465                 470         


<210>  10
<211>  1419
<212>  DNA
<213>  Oryza sativa 

<400>  10
atgcatcagc accaacatca gagcggttct atggactccg gctactcctc ctcctacgcc       60

gccgccgccg ggatgcacgt cgtgatctgc ccgtggctcg ccttcggcca cctgctcccg      120

tgcctcgacc tcgcccagcg cctcgcgtcg cggggccacc gcgtgtcgtt cgtctccacg      180

ccgcggaaca tatcccgcct cccgccggtg cgccccgcgc tcgcgccgct cgtcgccttc      240

gtggcgctgc cgctcccgcg cgtcgagggg ctccccgacg gcgccgagtc caccaacgac      300

gtcccccacg acaggccgga catggtcgag ctccaccgga gggccttcga cgggctcgcc      360

gcgcccttct cggagttctt gggcaccgcg tgcgccgact gggtcatcgt cgacgtcttc      420

caccactggg ccgcagccgc cgctctcgag cacaaggtgc catgtgcaat gatgttgttg      480

ggctctgcac atatgatcgc ttccatagca gacagacggc tcgagcgcgc ggagacagag      540

tcgcctgcgg ctgccgggca gggacgccca gcggcggcgc caacgttcga ggtggcgagg      600

atgaagttga tacgaaccaa aggctcatcg ggaatgtccc tcgccgagcg cttctccttg      660

acgctctcga ggagcagcct cgtcgtcggg cggagctgcg tggagttcga gccggagacc      720

gtcccgctcc tgtcgacgct ccgcggtaag cctattacct tccttggcct tatgccgccg      780

ttgcatgaag gccgccgcga ggacggcgag gatgccaccg tccgctggct cgacgcgcag      840

ccggccaagt ccgtcgtgta cgtcgcgcta ggcagcgagg tgccactggg agtggagaag      900

gtccacgagc tcgcgctcgg gctggagctc gccgggacgc gcttcctctg ggctcttagg      960

aagcccactg gcgtctccga cgccgacctc ctccccgccg gcttcgagga gcgcacgcgc     1020

ggccgcggcg tcgtggcgac gagatgggtt cctcagatga gcatactggc gcacgccgcc     1080

gtgggcgcgt tcctgaccca ctgcggctgg aactcgacca tcgaggggct catgttcggc     1140

cacccgctta tcatgctgcc gatcttcggc gaccagggac cgaacgcgcg gctaatcgag     1200

gcgaagaacg ccggattgca ggtggcaaga aacgacggcg atggatcgtt cgaccgagaa     1260

ggcgtcgcgg cggcgattcg tgcagtcgcg gtggaggaag aaagcagcaa agtgtttcaa     1320

gccaaagcca agaagctgca ggagatcgtc gcggacatgg cctgccatga gaggtacatc     1380

gacggattca ttcagcaatt gagatcttac aaggattga                            1419





<210>  11

<400>  11
000

<210>  12

<400>  12
000

<210>  13
<211>  460
<212>  PRT
<213>  Stevia rebaudiana 

<400>  13

Met Ala Glu Gln Gln Lys Ile Lys Lys Ser Pro His Val Leu Leu Ile 
1               5                   10                  15      


Pro Phe Pro Leu Gln Gly His Ile Asn Pro Phe Ile Gln Phe Gly Lys 
            20                  25                  30          


Arg Leu Ile Ser Lys Gly Val Lys Thr Thr Leu Val Thr Thr Ile His 
        35                  40                  45              


Thr Leu Asn Ser Thr Leu Asn His Ser Asn Thr Thr Thr Thr Ser Ile 
    50                  55                  60                  


Glu Ile Gln Ala Ile Ser Asp Gly Cys Asp Glu Gly Gly Phe Met Ser 
65                  70                  75                  80  


Ala Gly Glu Ser Tyr Leu Glu Thr Phe Lys Gln Val Gly Ser Lys Ser 
                85                  90                  95      


Leu Ala Asp Leu Ile Lys Lys Leu Gln Ser Glu Gly Thr Thr Ile Asp 
            100                 105                 110         


Ala Ile Ile Tyr Asp Ser Met Thr Glu Trp Val Leu Asp Val Ala Ile 
        115                 120                 125             


Glu Phe Gly Ile Asp Gly Gly Ser Phe Phe Thr Gln Ala Cys Val Val 
    130                 135                 140                 


Asn Ser Leu Tyr Tyr His Val His Lys Gly Leu Ile Ser Leu Pro Leu 
145                 150                 155                 160 


Gly Glu Thr Val Ser Val Pro Gly Phe Pro Val Leu Gln Arg Trp Glu 
                165                 170                 175     


Thr Pro Leu Ile Leu Gln Asn His Glu Gln Ile Gln Ser Pro Trp Ser 
            180                 185                 190         


Gln Met Leu Phe Gly Gln Phe Ala Asn Ile Asp Gln Ala Arg Trp Val 
        195                 200                 205             


Phe Thr Asn Ser Phe Tyr Lys Leu Glu Glu Glu Val Ile Glu Trp Thr 
    210                 215                 220                 


Arg Lys Ile Trp Asn Leu Lys Val Ile Gly Pro Thr Leu Pro Ser Met 
225                 230                 235                 240 


Tyr Leu Asp Lys Arg Leu Asp Asp Asp Lys Asp Asn Gly Phe Asn Leu 
                245                 250                 255     


Tyr Lys Ala Asn His His Glu Cys Met Asn Trp Leu Asp Asp Lys Pro 
            260                 265                 270         


Lys Glu Ser Val Val Tyr Val Ala Phe Gly Ser Leu Val Lys His Gly 
        275                 280                 285             


Pro Glu Gln Val Glu Glu Ile Thr Arg Ala Leu Ile Asp Ser Asp Val 
    290                 295                 300                 


Asn Phe Leu Trp Val Ile Lys His Lys Glu Glu Gly Lys Leu Pro Glu 
305                 310                 315                 320 


Asn Leu Ser Glu Val Ile Lys Thr Gly Lys Gly Leu Ile Val Ala Trp 
                325                 330                 335     


Cys Lys Gln Leu Asp Val Leu Ala His Glu Ser Val Gly Cys Phe Val 
            340                 345                 350         


Thr His Cys Gly Phe Asn Ser Thr Leu Glu Ala Ile Ser Leu Gly Val 
        355                 360                 365             


Pro Val Val Ala Met Pro Gln Phe Ser Asp Gln Thr Thr Asn Ala Lys 
    370                 375                 380                 


Leu Leu Asp Glu Ile Leu Gly Val Gly Val Arg Val Lys Ala Asp Glu 
385                 390                 395                 400 


Asn Gly Ile Val Arg Arg Gly Asn Leu Ala Ser Cys Ile Lys Met Ile 
                405                 410                 415     


Met Glu Glu Glu Arg Gly Val Ile Ile Arg Lys Asn Ala Val Lys Trp 
            420                 425                 430         


Lys Asp Leu Ala Lys Val Ala Val His Glu Gly Gly Ser Ser Asp Asn 
        435                 440                 445             


Asp Ile Val Glu Phe Val Ser Glu Leu Ile Lys Ala 
    450                 455                 460 


<210>  14
<211>  1383
<212>  DNA
<213>  Stevia rebaudiana 

<400>  14
atggcggaac aacaaaagat caagaaatca ccacacgttc tactcatccc attcccttta       60

caaggccata taaacccttt catccagttt ggcaaacgat taatctccaa aggtgtcaaa      120

acaacacttg ttaccaccat ccacacctta aactcaaccc taaaccacag taacaccacc      180

accacctcca tcgaaatcca agcaatttcc gatggttgtg atgaaggcgg ttttatgagt      240

gcaggagaat catatttgga aacattcaaa caagttgggt ctaaatcact agctgactta      300

atcaagaagc ttcaaagtga aggaaccaca attgatgcaa tcatttatga ttctatgact      360

gaatgggttt tagatgttgc aattgagttt ggaatcgatg gtggttcgtt tttcactcaa      420

gcttgtgttg taaacagctt atattatcat gttcataagg gtttgatttc tttgccattg      480

ggtgaaactg tttcggttcc tggatttcca gtgcttcaac ggtgggagac accgttaatt      540

ttgcagaatc atgagcaaat acagagccct tggtctcaga tgttgtttgg tcagtttgct      600

aatattgatc aagcacgttg ggtcttcaca aatagttttt acaagctcga ggaagaggta      660

atagagtgga cgagaaagat atggaacttg aaggtaatcg ggccaacact tccatccatg      720

taccttgaca aacgacttga tgatgataaa gataacggat ttaatctcta caaagcaaac      780

catcatgagt gcatgaactg gttagacgat aagccaaagg aatcagttgt ttacgtagca      840

tttggtagcc tggtgaaaca tggacccgaa caagtggaag aaatcacacg ggctttaata      900

gatagtgatg tcaacttctt gtgggttatc aaacataaag aagagggaaa gctcccagaa      960

aatctttcgg aagtaataaa aaccggaaag ggtttgattg tagcatggtg caaacaattg     1020

gatgtgttag cacacgaatc agtaggatgc tttgttacac attgtgggtt caactcaact     1080

cttgaagcaa taagtcttgg agtccccgtt gttgcaatgc ctcaattttc ggatcaaact     1140

acaaatgcca agcttctaga tgaaattttg ggtgttggag ttagagttaa ggctgatgag     1200

aatgggatag tgagaagagg aaatcttgcg tcatgtatta agatgattat ggaggaggaa     1260

agaggagtaa taatccgaaa gaatgcggta aaatggaagg atttggctaa agtagccgtt     1320

catgaaggtg gtagctcaga caatgatatt gtcgaatttg taagtgagct aattaaggct     1380

taa                                                                   1383


<210>  15
<211>  806
<212>  PRT
<213>  Stevia rebaudiana 

<400>  15

Met Ala Glu Arg Val Leu Thr Arg Val His Ser Leu Arg Glu Arg Leu 
1               5                   10                  15      


Asp Ser Thr Leu Ala Thr His Arg Asn Glu Ile Leu Leu Phe Leu Ser 
            20                  25                  30          


Arg Ile Glu Ser His Gly Lys Gly Ile Leu Lys Pro His Gln Val Met 
        35                  40                  45              


Thr Glu Phe Glu Ala Ile Cys Lys Glu Asp Gln Ser Lys Leu Ser Asp 
    50                  55                  60                  


Gly Ala Phe Tyr Glu Val Leu Lys Cys Thr Gln Glu Ala Ile Val Gln 
65                  70                  75                  80  


Pro Pro Trp Val Ala Leu Ala Ile Arg Leu Arg Pro Gly Val Trp Glu 
                85                  90                  95      


Tyr Val Arg Val Asn Val Asn Val Leu Val Val Glu Glu Leu Ser Val 
            100                 105                 110         


Pro Glu Tyr Leu His Phe Lys Glu Glu Leu Val Asn Gly Thr Ser Asn 
        115                 120                 125             


Gly Asn Phe Val Leu Glu Leu Asp Phe Glu Pro Phe Thr Ala Ser Phe 
    130                 135                 140                 


Pro Arg Pro Thr Leu Thr Lys Ser Ile Gly Asn Gly Val Glu Phe Leu 
145                 150                 155                 160 


Asn Arg His Leu Ser Ala Lys Met Phe His Asp Lys Asp Ser Met His 
                165                 170                 175     


Pro Leu Leu Asp Phe Leu Arg Thr His His Tyr Lys Gly Lys Thr Met 
            180                 185                 190         


Met Leu Asn Asp Arg Ile Gln Asn Leu Asn Ala Leu Gln Ser Val Leu 
        195                 200                 205             


Arg Lys Ala Ser Glu Tyr Leu Ser Thr Leu Asp Ala Ala Thr Pro Tyr 
    210                 215                 220                 


Ser Glu Phe Glu His Lys Phe Gln Glu Ile Gly Leu Glu Arg Gly Trp 
225                 230                 235                 240 


Gly Asp Lys Ala Glu Val Val Met Glu Met Ile His Met Leu Leu Asp 
                245                 250                 255     


Leu Leu Glu Ala Pro Asp Ala Cys Thr Leu Glu Lys Phe Leu Gly Arg 
            260                 265                 270         


Ile Pro Met Val Phe Asn Val Val Ile Leu Ser Pro His Gly Tyr Phe 
        275                 280                 285             


Ala Gln Glu Asn Val Leu Gly Tyr Pro Asp Thr Gly Gly Gln Val Val 
    290                 295                 300                 


Tyr Ile Leu Asp Gln Val Pro Ala Leu Glu Arg Glu Met Leu Lys Arg 
305                 310                 315                 320 


Ile Lys Glu Gln Gly Leu Asp Ile Ile Pro Arg Ile Leu Ile Val Thr 
                325                 330                 335     


Arg Leu Leu Pro Asp Ala Val Gly Thr Thr Cys Gly Gln Arg Leu Glu 
            340                 345                 350         


Lys Val Phe Gly Ala Glu His Ser His Ile Leu Arg Val Pro Phe Arg 
        355                 360                 365             


Thr Glu Lys Gly Ile Leu Arg Lys Trp Ile Ser Arg Phe Glu Val Trp 
    370                 375                 380                 


Pro Tyr Ile Glu Thr Phe Thr Glu Asp Val Ala Lys Glu Val Thr Ala 
385                 390                 395                 400 


Glu Leu Gln Ala Lys Pro Asp Leu Ile Ile Gly Asn Tyr Ser Glu Gly 
                405                 410                 415     


Asn Leu Val Ala Ser Leu Leu Ala His Lys Leu Gly Val Thr Gln Cys 
            420                 425                 430         


Thr Ile Ala His Ala Leu Glu Lys Thr Lys Tyr Pro Asp Ser Asp Ile 
        435                 440                 445             


Tyr Trp Lys Asn Phe Glu Glu Lys Tyr His Phe Ser Ser Gln Phe Thr 
    450                 455                 460                 


Ala Asp Leu Ile Ala Met Asn His Thr Asp Phe Ile Ile Thr Ser Thr 
465                 470                 475                 480 


Phe Gln Glu Ile Ala Gly Ser Lys Asp Thr Val Gly Gln Tyr Glu Ser 
                485                 490                 495     


His Thr Ala Phe Thr Met Pro Gly Leu Tyr Arg Val Val His Gly Ile 
            500                 505                 510         


Asp Val Phe Asp Pro Lys Phe Asn Ile Val Ser Pro Gly Ala Asp Met 
        515                 520                 525             


Gly Ile Tyr Tyr Ser Tyr Thr Glu Lys Glu Lys Arg Leu Thr Ala Leu 
    530                 535                 540                 


His Pro Glu Ile Asp Glu Leu Leu Phe Ser Ser Val Glu Asn Glu Glu 
545                 550                 555                 560 


His Leu Cys Val Leu Lys Asp Lys Ser Lys Pro Ile Leu Phe Thr Met 
                565                 570                 575     


Ala Arg Leu Asp Asn Val Lys Asn Leu Thr Gly Leu Val Glu Trp Tyr 
            580                 585                 590         


Ala Lys Asn Asp Arg Leu Arg Glu Leu Val Asn Leu Val Val Val Gly 
        595                 600                 605             


Gly Asp Arg Arg Lys Glu Ser Lys Asp Leu Glu Glu Gln Ala Gln Met 
    610                 615                 620                 


Gln Lys Met His Glu Leu Ile Glu Thr Tyr Lys Leu Asn Gly Gln Phe 
625                 630                 635                 640 


Arg Trp Ile Ser Ser Gln Met Asn Arg Val Arg Asn Gly Glu Leu Tyr 
                645                 650                 655     


Arg Val Ile Ala Asp Thr Arg Gly Ala Phe Ile Gln Pro Ala Phe Tyr 
            660                 665                 670         


Glu Ala Phe Gly Leu Thr Val Val Glu Ala Met Thr Cys Gly Leu Pro 
        675                 680                 685             


Thr Phe Ala Thr Leu His Gly Gly Pro Ala Glu Ile Ile Val His Gly 
    690                 695                 700                 


Lys Ser Gly Phe His Ile Asp Pro Tyr His Gly Asp Gln Val Thr Glu 
705                 710                 715                 720 


Leu Leu Val Asn Phe Phe Glu Lys Thr Lys Gln Asp Pro Gly His Trp 
                725                 730                 735     


Glu Ala Ile Ser Lys Gly Gly Leu Gln Arg Ile Gln Glu Lys Tyr Thr 
            740                 745                 750         


Trp Gln Ile Tyr Ser Asp Arg Leu Leu Thr Leu Ala Gly Val Tyr Gly 
        755                 760                 765             


Phe Trp Lys His Val Ser Lys Leu Asp Arg Leu Glu Ile Arg Arg Tyr 
    770                 775                 780                 


Leu Glu Met Phe Tyr Ala Leu Lys Tyr Arg Lys Leu Ala Glu Ser Val 
785                 790                 795                 800 


Pro Leu Ala Val Asp Glu 
                805     


<210>  16
<211>  2421
<212>  DNA
<213>  Stevia rebaudiana  

<400>  16
atggcggaac gtgtactcac tcgtgttcac agtcttcgtg agcgtctcga ttcaactctc       60

gcaactcatc gtaatgaaat cctcttgttt ctttcaagga ttgaaagcca tggaaaagga      120

atattgaagc ctcatcaagt tatgactgaa tttgaagcta tctgcaaaga agatcagagc      180

aaactctctg atggtgcttt ttatgaagtt cttaaatgca cacaggaagc aatagtgcaa      240

cctccatggg ttgcactcgc gatccgtctt cgacccggtg tttgggaata tgttagagtc      300

aatgttaatg ttttggtggt tgaagaatta agtgttcctg aatatcttca cttcaaagaa      360

gaattggtta atggaacatc gaatggcaac ttcgtgttgg aactggattt tgaacctttt      420

accgcatcgt ttcctcgacc aactttaacc aagtctattg gtaatggtgt tgagtttcta      480

aacagacatt tatctgctaa aatgtttcat gataaggata gcatgcaccc tcttcttgat      540

ttcctacgga ctcaccacta taagggaaag acaatgatgt tgaatgatag aatccaaaac      600

ctcaatgctc tacaatcggt gttgcgaaag gcgtcagagt acttatcaac actcgacgca      660

gcaacaccgt actctgagtt tgaacataag tttcaagaaa tcgggttgga gagaggttgg      720

ggtgataaag cggaggtcgt aatggagatg atccacatgc ttctagacct tctagaagca      780

cccgacgcat gcacactcga gaagtttctc ggaagaatcc caatggtttt caatgttgtc      840

attctttcgc ctcacggcta cttcgcccaa gaaaatgtgt tgggatatcc cgacactggc      900

ggtcaggttg tttacatctt ggatcaagtt cccgctctgg aacgcgagat gctcaaaagg      960

attaaggagc aaggactcga tatcattcct cgtatattga ttgttacgag gcttcttccc     1020

gacgcggttg ggaccacatg cgggcaacgt ttagagaaag tgtttggagc cgaacactcg     1080

catattcttc gggtcccgtt tagaaccgaa aagggtattc ttcgtaaatg gatctctcgt     1140

tttgaggtgt ggccttacat cgagactttc accgaggatg ttgctaaaga agttacagca     1200

gagttgcaag caaaaccaga tttgatcatt ggaaactata gtgaaggaaa tttggttgca     1260

tctttgctag ctcacaagtt gggtgtcact cagtgtacca ttgctcatgc tttggagaaa     1320

actaaatacc cggattctga tatctactgg aagaactttg aggagaaata tcatttctct     1380

tcgcagttta ccgctgatct tatcgctatg aaccataccg acttcatcat caccagtact     1440

ttccaagaaa ttgctggaag taaggacacg gttggacagt acgagagtca taccgcgttc     1500

acaatgccgg gattgtatcg ggtggttcac gggatcgatg tttttgaccc caaattcaat     1560

attgtttcac ccggggccga tatgggaatt tactactcgt ataccgagaa agaaaagagg     1620

ctcactgcgc ttcaccctga aatcgatgaa cttctcttta gttccgtcga aaacgaagaa     1680

cacttatgtg tgttgaagga taagagtaaa ccaatcttgt tcacaatggc gcgattggat     1740

aatgtgaaga atttaaccgg actggttgaa tggtacgcta aaaacgaccg ccttcgtgag     1800

ctcgtgaacc tcgtggtcgt cggtggtgac cgaaggaaag agtcgaaaga tcttgaagaa     1860

caagctcaga tgcagaagat gcatgaactt atcgaaacct acaaactcaa cggtcagttc     1920

aggtggatat cctcacaaat gaaccgcgtg aggaacggtg agttgtatcg cgttattgct     1980

gacacacgag gtgcgtttat ccagcctgcg ttttacgagg cgtttgggtt gacggttgtg     2040

gaggccatga cttgtggcct gccgacattc gcgacacttc atggtgggcc cgctgagatt     2100

attgttcacg ggaaatccgg gttccatatt gacccgtatc acggtgacca ggtcaccgag     2160

ttgctggtca atttctttga gaaaactaaa caagacccgg gtcattggga ggccatttcc     2220

aagggtggtc tgcaacgtat tcaggagaaa tacacgtggc agatttattc agataggttg     2280

ttgacgcttg ccggagttta tggattctgg aagcatgtgt cgaagcttga caggctcgag     2340

atccgtcgtt atcttgaaat gttttacgcg ctcaagtatc gcaaactggc tgaatctgtt     2400

ccattggctg ttgatgagtg a                                               2421


<210>  17
<211>  810
<212>  PRT
<213>  Stevia rebaudiana

<400>  17

Met Ala Thr Ser Lys Leu Ser Arg Thr His Ser Met Arg Glu Arg Val 
1               5                   10                  15      


Glu Glu Thr Leu Ser Ala His Arg Asn Glu Ile Val Ser Leu Leu Ser 
            20                  25                  30          


Arg Tyr Val Ala Gln Gly Lys Ala Ile Leu Gln Pro His Gln Ile Leu 
        35                  40                  45              


His Glu Leu Glu Asn Ile Ile Gly Asp Val Thr Ser Arg Gln Lys Leu 
    50                  55                  60                  


Thr Asp Gly Pro Phe Gly Asp Ala Leu Lys Thr Ala Gln Glu Cys Ile 
65                  70                  75                  80  


Val Leu Pro Pro Phe Val Ala Leu Ala Val Arg Pro Arg Pro Gly Val 
                85                  90                  95      


Trp Glu Tyr Val Arg Val Asp Ala Tyr Gln Leu Ser Val Glu Gln Leu 
            100                 105                 110         


Thr Val Ser Glu Tyr Leu Thr Phe Lys Glu Glu Leu Val Gly Glu Ser 
        115                 120                 125             


Asn Ser Ser Leu Met Leu Glu Leu Asp Phe Glu Pro Phe Asn Ala Ser 
    130                 135                 140                 


Phe Pro Arg Pro Thr Arg Ser Ser Ser Ile Gly Asn Gly Val Gln Phe 
145                 150                 155                 160 


Leu Asn Arg His Leu Ser Ser Ser Met Phe Arg Ser Lys Asp Cys Leu 
                165                 170                 175     


Glu Pro Leu Leu Asp Phe Leu Arg Thr His Arg His Asn Gly His Val 
            180                 185                 190         


Met Met Leu Asn Asp Arg Ile Thr Ser Met Thr Arg Leu Gln Ser Ser 
        195                 200                 205             


Leu Val Lys Ala Glu Glu Tyr Leu Ser Lys Leu Pro Ser Asp Thr Asp 
    210                 215                 220                 


Tyr Ser Glu Phe Gln Tyr Glu Leu Gln Gly Met Gly Phe Glu Arg Gly 
225                 230                 235                 240 


Trp Gly Asn Asn Ala Glu Arg Ile Ile Glu Met Met His Leu Leu Ser 
                245                 250                 255     


Asp Ile Leu Gln Ala Pro Asp Pro Ser Ile Leu Glu Ser Phe Leu Ala 
            260                 265                 270         


Arg Ile Pro Met Val Phe Asn Val Val Ile Leu Ser Ile His Gly Tyr 
        275                 280                 285             


Phe Gly Gln Ala Asn Val Leu Gly Leu Pro Asp Thr Gly Gly Gln Ile 
    290                 295                 300                 


Val Tyr Ile Leu Asp Gln Val Arg Ala Leu Glu Asn Glu Met Leu Leu 
305                 310                 315                 320 


Lys Leu Lys His Gln Gly Leu Asp Ile Lys Pro Arg Ile Leu Ile Val 
                325                 330                 335     


Thr Arg Leu Ile Pro Asp Ala Lys Gly Thr Ser Cys Asn Gln Arg Leu 
            340                 345                 350         


Glu Arg Val Ser Gly Thr Glu His Thr His Ile Leu Arg Val Pro Phe 
        355                 360                 365             


Arg Thr Glu Lys Gly Ile Leu Arg Lys Trp Ile Ser Arg Phe Asp Val 
    370                 375                 380                 


Trp Pro Phe Leu Glu Lys Phe Thr Gln Asp Ala Ala Ser Glu Ile Ser 
385                 390                 395                 400 


Ala Glu Leu His Gly Thr Pro Asp Leu Ile Ile Gly Asn Tyr Ser Asp 
                405                 410                 415     


Gly Asn Leu Val Ala Ser Leu Leu Ser Tyr Lys Met Gly Val Thr Gln 
            420                 425                 430         


Cys Asn Ile Ala His Ala Leu Glu Lys Thr Lys Tyr Pro Asp Ser Asp 
        435                 440                 445             


Leu Tyr Trp Lys Lys Phe Asp Glu Lys Tyr His Phe Ser Cys Gln Phe 
    450                 455                 460                 


Thr Ala Asp Leu Leu Ala Met Asn Asn Ala Asp Phe Ile Ile Thr Ser 
465                 470                 475                 480 


Thr Tyr Gln Glu Ile Ala Gly Thr Lys Asn Thr Val Gly Gln Tyr Glu 
                485                 490                 495     


Ser His Ser Ser Phe Thr Leu Pro Gly Leu Tyr Arg Val Val His Gly 
            500                 505                 510         


Ile Asp Val Phe Asp Pro Lys Phe Asn Ile Val Ser Pro Gly Ala Asp 
        515                 520                 525             


Met Ser Ile Tyr Phe Ser Tyr Thr Glu Lys Glu Lys Arg Leu Thr Ser 
    530                 535                 540                 


Leu His Thr Thr Ile Glu Lys Leu Leu Phe Asp Pro Thr Gln Thr Glu 
545                 550                 555                 560 


Asp Tyr Ile Gly Asn Leu Ser Asp Lys Ser Lys Pro Ile Ile Phe Ser 
                565                 570                 575     


Met Ala Arg Leu Asp His Val Lys Asn Ile Thr Gly Leu Val Glu Trp 
            580                 585                 590         


Tyr Ala Lys Asn Glu Lys Leu Arg Gly Leu Ala Asn Leu Val Val Val 
        595                 600                 605             


Ala Gly Tyr Asn Asn Val Lys Arg Ser Ser Asp Arg Glu Glu Ile Ala 
    610                 615                 620                 


Glu Ile Glu Lys Met His Gln Leu Ile Lys Lys Tyr Lys Leu Asp Gly 
625                 630                 635                 640 


Gln Met Arg Trp Ile Ser Ala Gln Thr Asn Arg Ala Gln Asn Gly Glu 
                645                 650                 655     


Leu Tyr Arg Tyr Ile Ala Asp Gly Arg Gly Ile Phe Val Gln Pro Ala 
            660                 665                 670         


Ile Tyr Glu Ala Phe Gly Leu Thr Val Val Glu Ala Met Thr Cys Gly 
        675                 680                 685             


Leu Pro Thr Phe Ala Thr Cys His Gly Gly Pro Gly Glu Ile Ile Glu 
    690                 695                 700                 


Asn Gly Val Ser Gly Phe His Ile Asp Pro Tyr His Pro Asp Thr Ala 
705                 710                 715                 720 


Ser Ala Thr Met Ala Asp Phe Phe Gln Lys Cys Lys Glu Asp Pro Ser 
                725                 730                 735     


Tyr Trp Phe Lys Ile Ser Glu Ala Gly Leu Lys Arg Ile Tyr Glu Arg 
            740                 745                 750         


Tyr Thr Trp Lys Ile Tyr Ser Glu Arg Leu Met Thr Leu Ala Gly Val 
        755                 760                 765             


Tyr Ser Phe Trp Lys Tyr Val Ser Lys Leu Glu Arg Arg Glu Thr Arg 
    770                 775                 780                 


Arg Tyr Leu Glu Met Phe Tyr Ile Leu Lys Phe Arg Asp Leu Val Lys 
785                 790                 795                 800 


Ser Val Pro Val Ala Thr Asp Asp Glu Ala 
                805                 810 


<210>  18
<211>  2433
<212>  DNA
<213>  Stevia rebaudiana

<400>  18
atggcgacaa gtaagttgag cagaacgcat agtatgcgtg agcgtgttga agaaactctt       60

tccgctcatc gcaacgaaat cgtttctctt ctttctaggt atgtggctca ggggaaggcg      120

atattgcagc cgcatcagat actccatgaa cttgagaata tcatcggtga tgttacttcg      180

cgccaaaagc ttacagatgg tccgtttgga gatgcgttga agacagcaca ggaatgtata      240

gttctacctc catttgtagc tttagcagtt cgtccaagac ctggtgtttg ggaatacgtg      300

cgcgtggatg catatcaact aagtgtggaa caactaactg tttcagagta tcttaccttc      360

aaagaagaac ttgttggaga gtctaatagt tctttaatgc tcgagttgga ttttgagcca      420

tttaatgctt cgtttcctag accaacccgt tcttcatcca ttggcaatgg agttcagttc      480

ctgaatcgcc acctgtcgtc aagcatgttt cgcagcaaag attgtttaga accgcttctg      540

gatttcctac gcacacacag acataatgga catgtaatga tgttaaatga ccgcataaca      600

agcatgacta gacttcaatc ttctttggtc aaagcagagg aatatctttc taaactacca      660

tctgatacag actactctga gtttcaatat gaattgcaag gaatgggttt tgaaagagga      720

tggggaaaca atgctgaaag aatcattgag atgatgcatc ttctctcaga cattctacaa      780

gctccagatc cttccatttt ggaatctttt cttgctagaa tacctatggt gtttaatgtt      840

gttatattat caatacatgg ctactttggg caagcaaatg ttttgggttt gccagatact      900

ggtggccaga ttgtatatat attggatcaa gtccgtgcat tggaaaatga gatgcttctt      960

aaattaaagc accaaggact ggatatcaaa cctaggattc tgattgtgac tcggttaata     1020

cctgatgcaa aaggtacttc atgtaaccaa cgactggaaa gagtcagtgg aactgaacac     1080

acacatatac ttcgtgttcc ttttagaacc gagaaaggaa ttcttcgtaa atggatctca     1140

aggtttgatg tatggccttt tttggagaaa tttacacagg atgcagcaag tgaaatttct     1200

gctgagttgc atggtactcc agatcttata attggaaatt atagtgatgg caatcttgtt     1260

gcctctttat tatcttacaa aatgggagta acccagtgta acattgctca tgctttagag     1320

aaaacaaagt atccagattc tgatttatat tggaagaaat ttgatgagaa atatcacttt     1380

tcttgtcaat ttactgctga tcttttagcc atgaacaatg cagattttat catcaccagc     1440

acataccaag aaatcgcggg aacgaaaaat actgtcggac aatacgagag tcattcgtct     1500

ttcactctcc cggggctcta cagggttgtt catggtattg acgtttttga ccctaagttc     1560

aacattgtgt ctccaggggc agatatgtct atatacttct catacaccga gaaggaaaaa     1620

agacttacat ctcttcatac tacaattgag aagttattgt ttgaccctac acaaactgaa     1680

gattacattg gaaatctgag tgataaatca aaaccgataa ttttttcaat ggcaagactt     1740

gatcatgtga agaacattac gggtctggtt gagtggtacg ctaagaatga gaagcttaga     1800

ggactagcaa accttgttgt ggttgctggt tataataatg tgaagaggtc tagtgacaga     1860

gaagaaattg cagaaattga aaaaatgcat caacttatta agaaatacaa attagatggt     1920

cagatgagat ggatttcagc acaaacaaac cgcgcacaaa atggtgaact ttatcgctat     1980

attgctgatg gaaggggaat ctttgtacag cccgctattt atgaagcttt tgggctgaca     2040

gtggtggagg ccatgacttg tgggcttcca acatttgcaa cttgccatgg tgggccagga     2100

gagataattg aaaatggtgt ttcgggcttc catatcgacc cgtatcatcc ggatactgca     2160

tcagccacaa tggctgattt ttttcagaaa tgcaaggagg acccgagtta ttggttcaag     2220

atatctgaag cagggcttaa aagaatatat gaaaggtaca catggaaaat ttactctgaa     2280

cggttgatga cattagctgg agtttatagc ttctggaagt atgtctcgaa acttgagaga     2340

cgtgaaacaa gacgatatct tgagatgttt tatattctta agttccgtga tctggtaaaa     2400

tctgttccag tggctactga tgatgaggct tag                                  2433




<210>  19
<211>  811
<212>  PRT
<213>  Stevia rebaudiana 

<400>  19

Met Ala Thr Pro Lys Leu Thr Arg Thr Pro Ser Met Arg Glu Arg Leu 
1               5                   10                  15      


Glu Glu Thr Leu Ser Ala His Arg Asn Asp Ile Val Ser Leu Leu Ser 
            20                  25                  30          


Arg Tyr Val Asp Gln Gly Lys Ala Ile Leu Gln Pro His His Leu Leu 
        35                  40                  45              


Asp Glu Ile Asp Asn Phe Ile Gly Asp Gln Asn Cys Arg Gln Lys Leu 
    50                  55                  60                  


Ala Asp Ser Leu Phe Gly Glu Ile Leu Lys Ser Ala Gln Glu Gly Ile 
65                  70                  75                  80  


Ile Leu Pro Pro Tyr Val Thr Leu Ala Val Arg Pro Arg Pro Gly Val 
                85                  90                  95      


Trp Asp Phe Leu Arg Val Asn Val Asp Glu Leu Ser Val Glu Gln Leu 
            100                 105                 110         


Thr Val Ser Glu Tyr Leu Ser Phe Lys Glu Glu Leu Val Asp Gly Gln 
        115                 120                 125             


Ser Arg Asn Pro Phe Val Leu Glu Leu Asp Leu Glu Pro Phe Asn Ala 
    130                 135                 140                 


Thr Phe Pro Arg Met Ser Arg Ser Ser Ser Ile Gly Asn Gly Val Gln 
145                 150                 155                 160 


Phe Leu Asn Arg His Leu Ser Ser Ile Met Phe Arg Asn Lys Asp Cys 
                165                 170                 175     


Met Asp Pro Phe Leu Asp Phe Leu Arg Ala His Lys His Lys Gly Tyr 
            180                 185                 190         


Ala Met Met Leu Asn Asp Arg Ile Gln Thr Met Ser Arg Leu Glu Ser 
        195                 200                 205             


Ser Leu Ala Lys Ala Glu Asp His Leu Ser Lys Leu Pro Pro Glu Thr 
    210                 215                 220                 


Pro Tyr Ser Glu Phe Glu Tyr Val Leu Gln Gly Met Gly Phe Glu Arg 
225                 230                 235                 240 


Gly Trp Gly Asp Asn Cys Glu Arg Val Leu Gly Met Met His Leu Leu 
                245                 250                 255     


Ser Asp Ile Leu Gln Ala Pro Asp Pro Ser Ile Leu Glu Lys Phe Leu 
            260                 265                 270         


Gly Lys Met Pro Met Ile Phe Asn Val Val Val Leu Ser Ile His Gly 
        275                 280                 285             


Tyr Phe Gly Gln Ala Asn Val Leu Gly Leu Pro Asp Thr Gly Gly Gln 
    290                 295                 300                 


Val Val Tyr Ile Leu Asp Gln Val Arg Ser Leu Glu Asn Glu Met Leu 
305                 310                 315                 320 


Leu Lys Leu Arg His Gln Gly Leu Asp Ile Lys Pro Lys Ile Leu Ile 
                325                 330                 335     


Val Thr Arg Leu Ile Pro Asn Ala Lys Gly Thr Ser Cys Asn Gln Arg 
            340                 345                 350         


Leu Glu Lys Val Ser Gly Thr Glu Tyr Thr Tyr Ile Leu Arg Val Pro 
        355                 360                 365             


Phe Arg Thr Glu Lys Gly Ile Leu Gly Lys Trp Leu Ser Arg Phe Asp 
    370                 375                 380                 


Ile Trp Pro Tyr Leu Glu Ala Phe Thr Thr Asp Ala Ala Ser Glu Ile 
385                 390                 395                 400 


Ala Ala Glu Leu His Gly Val Pro Asp Leu Leu Ile Gly Asn Tyr Ser 
                405                 410                 415     


Asp Gly Asn Leu Val Ala Ser Leu Leu Ser Asn Lys Leu Gly Val Thr 
            420                 425                 430         


Gln Cys Asn Ile Ala His Ala Leu Glu Lys Thr Lys Tyr Pro Asp Ser 
        435                 440                 445             


Asp Leu Tyr Trp Lys Lys Phe Glu Asp Lys Tyr His Phe Ser Cys Gln 
    450                 455                 460                 


Phe Thr Ala Asp Leu Leu Ala Met Asn Asn Ala Asp Phe Ile Ile Thr 
465                 470                 475                 480 


Ser Thr Tyr Gln Glu Ile Ala Gly Thr Lys Asn Thr Val Gly Gln Tyr 
                485                 490                 495     


Glu Asn His Ser Ser Phe Thr Leu Pro Gly Leu Tyr Arg Val Val His 
            500                 505                 510         


Gly Ile Asp Val Phe Asp Pro Lys Phe Asn Ile Val Ser Pro Gly Ala 
        515                 520                 525             


Asp Met Ala Ile Tyr Phe Ser Tyr Ala Asp Lys Glu Arg Arg Leu Thr 
    530                 535                 540                 


Ser Leu His Pro Thr Ile Glu Lys Leu Leu Phe Asp Thr Glu Gln Asn 
545                 550                 555                 560 


Asp Val His Ile Gly Asn Ile Asn Asp Pro Ser Lys Pro Met Ile Phe 
                565                 570                 575     


Thr Met Ala Arg Leu Asp His Val Lys Asn Ile Thr Gly Phe Val Glu 
            580                 585                 590         


Cys Tyr Ala Lys Asn Asn Lys Leu Arg Glu His Ala Asn Leu Val Val 
        595                 600                 605             


Ile Ala Gly Tyr Asn Asp Ala Lys Lys Ser Ser Asp Arg Glu Glu Ile 
    610                 615                 620                 


Ala Glu Ile Glu Lys Met His Asn Leu Ile Lys Gln Tyr Lys Leu Asp 
625                 630                 635                 640 


Gly Gln Met Arg Trp Ile Ser Ala Gln Thr Asn Arg Ala Arg Asn Gly 
                645                 650                 655     


Glu Phe Tyr Arg Tyr Ile Ala Asp Gly Arg Gly Val Phe Val Gln Pro 
            660                 665                 670         


Ala Phe Tyr Glu Ala Phe Gly Leu Thr Val Val Glu Ala Met Thr Cys 
        675                 680                 685             


Gly Leu Pro Thr Phe Ala Thr Cys His Gly Gly Pro Ala Glu Ile Ile 
    690                 695                 700                 


Glu Asp Gly Val Ser Gly Phe His Ile Asp Pro Tyr His Pro Asp Lys 
705                 710                 715                 720 


Met Ser Thr Thr Leu Ala Asp Phe Phe Gln Lys Cys Lys Glu Glu Pro 
                725                 730                 735     


Ser Tyr Trp Gly Lys Ile Ser Asp Gly Gly Leu Lys Arg Ile Ser Glu 
            740                 745                 750         


Arg Tyr Thr Trp Lys Ile Tyr Ser Glu Arg Leu Met Thr Leu Ala Gly 
        755                 760                 765             


Val Tyr Ser Phe Trp Lys Tyr Val Ser Lys Leu Glu Arg Arg Glu Thr 
    770                 775                 780                 


Arg Arg Tyr Leu Glu Met Phe Tyr Ile Leu Lys Phe Arg Gln Leu Val 
785                 790                 795                 800 


Lys Ser Val Pro Leu Ala Val Asp Glu Glu Pro 
                805                 810     


<210>  20
<211>  2436
<212>  DNA
<213>  Stevia rebaudiana  

<400>  20
atggcgacac ctaagcttac gcgaacacca agcatgcgag agcgtcttga agaaacttta       60

tcagctcatc gcaacgatat cgtctctctt ctttccaggt atgtagatca aggtaaggcc      120

atattgcagc cccaccacct acttgacgaa atcgataact tcatcggaga tcaaaattgc      180

cgccaaaagc ttgctgatag tctattcggt gaaatcctca agtccgcaca ggaaggtata      240

attcttcctc catatgtaac gcttgctgtt cgtccaagac ctggtgtttg ggactttttg      300

cgtgtgaatg tcgatgaatt gagtgtcgag caacttactg tttctgagta tttaagcttc      360

aaggaggagc ttgtagatgg ccagagtagg aacccgtttg tgttggaact ggatctggaa      420

ccgtttaatg caacatttcc ccggatgtca cgatcttcat ccatcggcaa tggagttcag      480

tttctcaacc gtcatctctc gtcaattatg tttcgcaaca aagattgtat ggatccgttt      540

cttgatttcc ttcgtgctca taaacataaa ggatacgcga tgatgttgaa tgatcggata      600

caaacaatgt ctagacttga atcttcttta gcaaaagcgg aggatcatct ctctaaacta      660

ccacccgaaa caccgtactc cgaattcgaa tacgtattgc aaggaatggg gtttgaaaga      720

ggttgggggg ataattgtga aagagttctt ggtatgatgc atcttctttc tgacattctt      780

caagctccag atccttcgat tcttgaaaag tttcttggaa agatgccgat gatcttcaat      840

gttgttgtgt tatcgattca tggttacttt ggtcaggcta atgttttggg tttgccggat      900

accggtggtc aggttgtata tatattggat caagtacgtt ctttggagaa tgaaatgtta      960

cttaaattaa ggcatcaagg acttgatatc aaacccaaga ttctaattgt aactcgattg     1020

ataccaaatg ccaaaggtac ttcatgcaac caacgattgg agaaagtaag tggaaccgaa     1080

tacacgtata tattacgtgt cccttttagg acagagaaag ggattcttgg taaatggtta     1140

tcaaggtttg atatatggcc ttatttggag gcgtttacaa cggatgcagc aagtgaaatt     1200

gctgctgagt tacacggtgt tccggatctt ttaataggaa actacagtga tgggaatctc     1260

gttgcctcct tgctatctaa caaattgggc gtaacccagt gcaacattgc acacgcgtta     1320

gagaaaacaa agtatccaga ttccgactta tattggaaga aatttgagga caaatatcac     1380

ttttcatgtc aatttaccgc cgaccttcta gcaatgaaca atgcagattt tatcatcact     1440

agcacatacc aagagattgc aggaacgaaa aacaccgttg gacaatacga gaatcattca     1500

tcgttcactc ttccgggtct atacagggtt gttcacggta tcgatgtctt tgacccgaag     1560

ttcaacatcg tgtcaccagg ggcagatatg gcaatttact tctcatatgc cgataaagag     1620

agacgactta catctctaca tcccacaatt gagaagctat tgttcgacac tgagcagaac     1680

gatgtacaca ttggaaatat aaatgacccg tctaaaccca tgattttcac aatggcgagg     1740

cttgatcatg tgaagaatat aactggattc gtcgagtgtt atgctaaaaa taataagttg     1800

agggaacacg caaatcttgt ggttattgct ggttataatg acgcgaagaa atcaagtgat     1860

cgagaagaaa ttgcggaaat tgaaaagatg cataatctta tcaagcaata caaacttgat     1920

ggtcagatga gatggatatc agcccaaaca aaccgggccc gaaatgggga attttatcgg     1980

tatatcgctg atggtagggg cgttttcgtc cagcccgctt tctatgaagc atttgggctt     2040

acggttgtgg aggcgatgac atgtgggctc ccaacatttg ccacgtgtca tggtgggcct     2100

gctgagatca ttgaggatgg tgtgtcgggg ttccatattg atccatatca tcctgataag     2160

atgtcgacta cgttagctga tttttttcaa aagtgcaaag aggaacctag ttactggggt     2220

aaaatatccg atggcgggct gaaaagaata agtgaaaggt acacatggaa gatatattcg     2280

gaacggttga tgacgttggc gggcgtatat agcttttgga aatatgtgtc aaaactcgag     2340

aggcgtgaaa cccgtcgata ccttgagatg ttctacattt taaagtttcg tcaactggtg     2400

aagtcggttc cgctagctgt tgatgaggag ccgtaa                               2436


<210>  21
<211>  842
<212>  PRT
<213>  Stevia rebaudiana 

<400>  21

Met Ala Ser Ala Ser Ser Ser Ile Met Lys Arg Ser Glu Ser Ile Val 
1               5                   10                  15      


Asp Thr Met Pro Glu Ala Leu Lys Gln Ser Arg Tyr His Met Lys Lys 
            20                  25                  30          


Cys Phe Leu Lys Tyr Val Glu Lys Gly Ile Arg Met Met Lys Arg His 
        35                  40                  45              


His Leu Ile Gln Glu Met Glu Thr Ala Ile Glu Asp Lys Asp Glu Lys 
    50                  55                  60                  


Ala Gln Leu Leu Asp Gly Leu Leu Gly Tyr Ile Leu Cys Thr Thr Gln 
65                  70                  75                  80  


Glu Ala Ala Val Val Pro Pro Cys Val Ala Phe Ala Ile Arg Pro Asn 
                85                  90                  95      


Pro Gly Phe Trp Glu Phe Val Lys Val Asn Ser Asn Asp Leu Ser Val 
            100                 105                 110         


Asp Gly Ile Thr Ala Thr Asp Tyr Leu Lys Phe Lys Glu Met Ile Val 
        115                 120                 125             


Asp Glu Thr Trp Ala Lys Asp Glu Asn Ala Leu Glu Ile Asp Phe Gly 
    130                 135                 140                 


Ser Met Asp Phe Asn Leu Pro Asn Met Ser Leu Ser Cys Ser Ile Gly 
145                 150                 155                 160 


Asn Gly Val Asn Phe Thr Ser Lys Phe Ile Thr Cys Lys Leu Tyr Ala 
                165                 170                 175     


Gln Ser Ser Cys Gln Gln Leu Leu Val Asp Tyr Leu Leu Ser Leu Asn 
            180                 185                 190         


His Gln Gly Glu Asn Leu Met Ile Asn Asp Ala Leu Asn Ser Val Ser 
        195                 200                 205             


Lys Leu Arg Ala Ala Leu Ile Val Ala His Ala Ser Leu Ser Ser Leu 
    210                 215                 220                 


Pro Asn Asp Thr Pro Tyr Gln Ser Phe Glu Leu Arg Phe Lys Glu Trp 
225                 230                 235                 240 


Gly Phe Glu Lys Gly Trp Gly Asp Asn Ala Glu Arg Ala Arg Glu Thr 
                245                 250                 255     


Ile Arg Phe Leu Leu Glu Val Leu Gln Ala Pro Asp Pro Ile Asn Leu 
            260                 265                 270         


Glu Ala Leu Phe Ser Arg Ile Pro Asn Ile Phe Asn Val Val Leu Phe 
        275                 280                 285             


Ser Ile His Gly Tyr Phe Gly Gln Ser Asn Val Leu Gly Leu Pro Asp 
    290                 295                 300                 


Thr Gly Gly Gln Val Val Tyr Val Leu Asp Gln Val Val Ala Met Glu 
305                 310                 315                 320 


Glu Glu Leu Leu Met Arg Ile Lys Gln Gln Gly Leu Asn Phe Lys Pro 
                325                 330                 335     


Gln Ile Leu Val Val Thr Arg Leu Leu Pro Asp Ala Lys Gly Thr Lys 
            340                 345                 350         


Cys Asn Gln Val Leu Glu Pro Val Leu Asn Thr Lys His Ser His Ile 
        355                 360                 365             


Leu Arg Val Pro Phe Arg Thr Asp Lys Gly Val Leu Arg Lys Trp Val 
    370                 375                 380                 


Ser Arg Phe Asp Ile Tyr Pro Tyr Leu Glu Asn Phe Thr Gln Asp Ala 
385                 390                 395                 400 


Ser Ala Lys Ile Ile Glu Met Met Glu Gly Lys Pro Asp Leu Ile Ile 
                405                 410                 415     


Gly Asn Tyr Thr Asp Gly Asn Leu Val Ala Ser Leu Met Ala Asn Lys 
            420                 425                 430         


Leu Gly Thr Thr Leu Gly Thr Ile Ala His Ala Leu Glu Lys Thr Lys 
        435                 440                 445             


Tyr Glu Asp Ser Asp Met Asn Trp Lys Gln Phe Asp Pro Lys Tyr His 
    450                 455                 460                 


Phe Ser Cys Gln Phe Thr Ala Asp Met Ile Ala Met Asn Ser Ala Asp 
465                 470                 475                 480 


Phe Ile Ile Thr Ser Thr Phe Gln Glu Ile Ala Gly Ser Lys Asp Arg 
                485                 490                 495     


Pro Gly Gln Tyr Glu Ser His Glu Ala Phe Thr Leu Pro Gly Leu Tyr 
            500                 505                 510         


Arg Val Val Ser Gly Ile Asn Val Phe Asp Pro Lys Phe Asn Ile Ala 
        515                 520                 525             


Ser Pro Gly Ala Asp Gln Thr Val Tyr Phe Pro Tyr Thr Glu Thr Lys 
    530                 535                 540                 


Lys Arg Phe Thr Ala Phe Gln Pro Ala Ile Glu Glu Leu Leu Phe Ser 
545                 550                 555                 560 


Lys Val Glu Asn Glu Glu His Ile Gly Tyr Leu Glu Asp Lys Thr Lys 
                565                 570                 575     


Pro Ile Ile Phe Ser Met Ala Arg Leu Asp Thr Val Lys Asn Ile Thr 
            580                 585                 590         


Gly Leu Thr Glu Trp Phe Gly Glu Asn Lys Arg Leu Arg Ser Leu Val 
        595                 600                 605             


Asn Leu Val Ile Val Ala Gly Phe Phe Asp Pro Ser Lys Ser Lys Asp 
    610                 615                 620                 


Arg Glu Glu Met Ala Glu Ile Lys Lys Met His Leu Leu Ile Glu Lys 
625                 630                 635                 640 


Tyr Gln Leu Lys Gly Gln Ile Arg Trp Ile Ala Ala Gln Thr Asp Lys 
                645                 650                 655     


Asn Arg Asn Ser Glu Leu Tyr Arg Phe Ile Ala Asp Ser Lys Gly Ala 
            660                 665                 670         


Phe Val Gln Pro Ala Leu Tyr Glu Ala Phe Gly Leu Thr Val Ile Glu 
        675                 680                 685             


Ala Met Asn Cys Gly Leu Pro Thr Phe Ala Thr Asn Gln Gly Gly Pro 
    690                 695                 700                 


Ala Glu Ile Ile Val Asp Gly Val Ser Gly Phe Gln Ile Asp Pro Asn 
705                 710                 715                 720 


Phe Gly Asp Gln Ser Ser Asn Lys Ile Ala Asp Phe Phe Gln Lys Cys 
                725                 730                 735     


Lys Glu Asp Pro Gly Tyr Trp Asn Asn Ile Ser Glu Gly Gly Leu Lys 
            740                 745                 750         


Arg Ile Tyr Glu Cys Tyr Thr Trp Lys Ile Tyr Ala Asn Lys Val Leu 
        755                 760                 765             


Asn Met Gly Asn Ile Tyr Ser Phe Trp Lys Arg Leu Asn Lys Glu Gln 
    770                 775                 780                 


Lys Glu Ala Lys Gln Arg Tyr Ile Glu Leu Phe Tyr Asn Leu His Tyr 
785                 790                 795                 800 


Lys Asn Leu Val Arg Thr Val Pro Ile Ala Ser Asp Glu Ala Gln Pro 
                805                 810                 815     


Ala Pro Val Ser Arg Ala Lys Leu Ala Thr Gln Pro Thr Arg Arg Thr 
            820                 825                 830         


Gln Ser Arg Leu Gln Arg Leu Phe Gly Ala 
        835                 840         


<210>  22
<211>  2529
<212>  DNA
<213>  Stevia rebaudiana  

<400>  22
atggcatctg cttcaagttc tatcatgaaa cggtctgaat caatagttga caccatgcca       60

gaagccttaa agcagagccg ctatcatatg aaaaaatgtt ttctaaaata tgtagaaaaa      120

ggaattcgca tgatgaaaag acatcatttg atacaagaaa tggagaccgc aattgaagac      180

aaggatgaaa aggctcagct tctagatggc ttacttggct acatcttgtg cacaactcag      240

gaagcagccg ttgttcctcc ttgtgttgca tttgctataa gaccgaatcc tggattctgg      300

gagtttgtta aagtcaactc taatgatcta tcggttgatg ggataactgc cacagattac      360

ttgaagttca aggaaatgat cgtagatgag acatgggcta aagatgaaaa tgcattggag      420

attgactttg gatcgatgga ctttaaccta ccaaacatga gtttatcttg ttcgattgga      480

aatggtgtta acttcacatc aaaattcatt acttgtaaac tttacgcaca atctagttgc      540

caacaactgc ttgttgatta cttgctctca ttgaatcatc aaggagaaaa tcttatgatc      600

aatgatgcat taaactcagt ctcaaaactt cgagcggctt taattgtagc tcatgcgtcg      660

ctatcttcgt tgcccaacga tactccatat caaagcttcg agcttagatt caaagaatgg      720

ggatttgaga agggatgggg agataacgcg gaacgcgcga gggaaacaat tcggtttctt      780

ttggaggttc ttcaagcacc cgatccgata aacctcgagg ctttattcag caggattcca      840

aacatattca acgttgtttt attctcgatt catgggtatt ttggtcaatc caatgttctt      900

ggattgcccg atactggtgg ccaagtggtt tatgttttgg atcaagtggt agctatggaa      960

gaagaactac tcatgaggat caaacaacaa ggactcaact tcaagcctca aattcttgtg     1020

gtgacccgac ttcttcctga tgctaaaggg accaagtgta atcaggtgtt ggaaccagtt     1080

ctgaacacga aacattcgca tattcttagg gttccattca ggactgataa aggtgttctt     1140

cgtaaatggg tatctcgatt tgatatctat ccatatctcg aaaacttcac tcaggatgca     1200

agtgcgaaaa tcattgaaat gatggaaggg aaaccggatc ttatcatcgg aaactatacc     1260

gatggaaacc ttgttgcatc actcatggct aacaaactcg gaacgacatt gggaacaatt     1320

gcacatgctt tggagaaaac caaatacgaa gattcagaca tgaattggaa gcaattcgac     1380

ccaaaatatc acttctcctg ccaatttaca gccgatatga ttgcaatgaa ctcagctgat     1440

ttcatcatca caagtacttt ccaagaaatc gctggaagta aagatagacc cggacaatat     1500

gaaagccatg aagcatttac acttccagga ttatacagag ttgtttcagg catcaacgtg     1560

ttcgatccca aattcaatat cgcgtctcca ggagccgatc aaaccgttta tttcccgtac     1620

accgaaacaa agaaacgatt cactgcattt caacccgcca tagaggaatt actcttcagt     1680

aaagttgaaa acgaagaaca cattggatac ttagaagaca aaaccaaacc gatcatattc     1740

tcaatggcgc gtctcgacac agttaagaac ataacaggac taaccgaatg gtttggagag     1800

aacaaacggc tccgaagctt ggttaatctt gtaatcgtgg cgggtttctt tgacccgtca     1860

aagtcaaaag acagagaaga aatggcggaa ataaagaaaa tgcatttatt gattgaaaaa     1920

tatcagctta aaggtcaaat aagatggatt gctgcacaaa ctgataagaa ccgaaacagt     1980

gagctttacc ggtttattgc tgactcaaaa ggcgcgtttg tgcagcccgc tttgtatgag     2040

gcgtttgggc tcacggttat tgaggcgatg aactgtggtt taccgacttt tgcaactaat     2100

caaggtggtc cagctgagat tatcgttgat ggtgtttctg ggttccagat tgatcctaat     2160

tttggtgatc agtctagtaa taagattgct gatttcttcc agaagtgtaa ggaagatcct     2220

ggttattgga ataatatttc agaaggcggt ttgaagcgta tatacgaatg ttatacttgg     2280

aagatttatg cgaataaagt gttgaatatg gggaacatat actcgttttg gaagcggtta     2340

aacaaggaac aaaaagaagc aaaacaaaga tacattgaac tattctacaa tctacactac     2400

aagaacttgg ttaggactgt accaattgct agtgatgaag ctcaacctgc accagtgtca     2460

agggcaaaac ttgcaacaca acccacaaga cgtacgcaat ccaggttgca aaggctgttt     2520

ggagcttaa                                                             2529


<210>  23
<211>  842
<212>  PRT
<213>  Stevia rebaudiana  

<400>  23

Met Ala Ala Ser Ser Ser Pro Ile Met Lys Arg Ser Glu Ser Val Leu 
1               5                   10                  15      


Asp Thr Met Pro Glu Ala Leu Arg Gln Ser Arg Tyr His Met Lys Lys 
            20                  25                  30          


Cys Phe Leu Lys Tyr Val Gly Lys Gly Lys Arg Met Val Lys Leu His 
        35                  40                  45              


His Leu Met Gln Glu Met Glu Thr Val Ile Glu Asp Lys Asp Glu Lys 
    50                  55                  60                  


Ala Gln Leu Leu Glu Gly Leu Leu Gly Tyr Ile Leu Cys Thr Thr Gln 
65                  70                  75                  80  


Glu Ala Ala Val Val Pro Pro Tyr Val Ala Phe Ala Ile Arg Pro Asn 
                85                  90                  95      


Pro Gly Phe Trp Glu Phe Val Lys Val Asn Ser Asn Asp Leu Ser Val 
            100                 105                 110         


Lys Gly Ile Thr Ser Thr Asp Tyr Leu Lys Phe Lys Glu Met Ile Val 
        115                 120                 125             


Asp Glu Thr Trp Ala Asn Asp Glu Asn Ala Leu Glu Ile Asp Phe Gly 
    130                 135                 140                 


Ala Met Asp Phe Asn Leu Pro Thr Met Ser Leu Ser Ser Ser Ile Gly 
145                 150                 155                 160 


Asn Gly Val Asn Phe Thr Ser Lys Phe Ile Ile Ser Lys Leu Tyr Ala 
                165                 170                 175     


His Ser Gly Ser Gln Leu Gln Ser Leu Val Asp Tyr Leu Leu Ser Leu 
            180                 185                 190         


Asn His Gln Gly Glu Lys Leu Met Ile Asn Asp Lys Leu Asn Thr Val 
        195                 200                 205             


Ser Lys Leu Gln Ala Ala Leu Ile Val Ala His Ser Phe Leu Ser Ser 
    210                 215                 220                 


Leu Pro Asn Asp Thr Pro Tyr Gln Ser Phe Glu Leu Arg Phe Lys Glu 
225                 230                 235                 240 


Trp Gly Phe Glu Lys Gly Trp Gly Asp Tyr Ala Glu Arg Val Gln Glu 
                245                 250                 255     


Thr Ile Arg Phe Leu Leu Glu Val Leu Gln Ala Pro Asp Pro Val Asn 
            260                 265                 270         


Leu Glu Ala Phe Phe Ser Arg Val Pro Asn Ile Phe Asn Ile Val Leu 
        275                 280                 285             


Phe Ser Ile His Gly Tyr Phe Gly Gln Ser Asn Val Leu Gly Leu Pro 
    290                 295                 300                 


Asp Thr Gly Gly Gln Val Val Tyr Val Leu Asp Gln Val Val Ala Met 
305                 310                 315                 320 


Glu Glu Glu Leu Leu Leu Arg Ile Lys Gln Gln Gly Leu Ser Phe Lys 
                325                 330                 335     


Pro His Ile Leu Val Val Thr Arg Leu Leu Pro Asp Ala Lys Gly Thr 
            340                 345                 350         


Glu Cys Ser Gln Val Leu Glu Pro Val Leu Asn Thr Lys His Ser His 
        355                 360                 365             


Ile Leu Arg Val Pro Phe Arg Thr Glu Lys Gly Val Leu Arg Lys Trp 
    370                 375                 380                 


Val Ser Arg Phe Asp Ile Tyr Pro Tyr Leu Glu Lys Phe Thr Gln Asp 
385                 390                 395                 400 


Ala Ser Ala Lys Ile Thr Glu Met Met Glu Gly Lys Pro Asp Leu Ile 
                405                 410                 415     


Ile Gly Asn Tyr Thr Asp Gly Asn Leu Val Ala Ser Leu Met Ala Asn 
            420                 425                 430         


Lys Leu Gly Ser Thr Leu Gly Thr Ile Ala His Ala Leu Glu Lys Thr 
        435                 440                 445             


Lys Tyr Glu Asp Ser Asp Met Lys Trp Lys His Leu Asp Thr Lys Tyr 
    450                 455                 460                 


His Phe Ser Cys Gln Phe Thr Ala Asp Met Ile Ala Met Asn Ser Ala 
465                 470                 475                 480 


Asp Phe Ile Ile Thr Ser Thr Phe Gln Glu Ile Ala Gly Ser Lys Asp 
                485                 490                 495     


Arg Pro Gly Gln Tyr Glu Ser His Glu Ala Phe Thr Leu Pro Gly Leu 
            500                 505                 510         


Tyr Arg Val Val Ser Gly Ile Asn Val Phe Asp Pro Lys Phe Asn Ile 
        515                 520                 525             


Ala Ser Pro Gly Ala Asp Gln Thr Val Tyr Phe Pro Tyr Thr Glu Thr 
    530                 535                 540                 


Pro Lys Arg Phe Thr Thr Phe Gln Pro Ala Ile Gln Glu Leu Leu Phe 
545                 550                 555                 560 


Ser Lys Val Glu Asn Asp Glu His Ile Gly Tyr Leu Glu Asp Lys Asn 
                565                 570                 575     


Lys Pro Ile Ile Phe Ser Met Ala Arg Leu Asp Met Val Lys Asn Ile 
            580                 585                 590         


Thr Gly Leu Thr Glu Trp Phe Gly Glu Asn Lys Arg Leu Arg Ser Leu 
        595                 600                 605             


Val Asn Leu Val Ile Val Ala Gly Phe Phe Asp Pro Ser Lys Ser Lys 
    610                 615                 620                 


Asp Arg Glu Glu Met Glu Glu Ile Lys Lys Met His Leu Leu Ile Glu 
625                 630                 635                 640 


Lys Tyr Glu Leu Lys Gly Gln Ile Arg Trp Ile Val Ala Gln Thr Asp 
                645                 650                 655     


Lys Asn Arg Asn Ser Glu Leu Tyr Arg Cys Ile Ala Asp Ser Lys Gly 
            660                 665                 670         


Ala Phe Val Gln Pro Ala Leu Tyr Glu Ala Phe Gly Leu Thr Val Ile 
        675                 680                 685             


Glu Ala Met Asn Cys Gly Leu Pro Thr Phe Ala Thr Asn Gln Gly Gly 
    690                 695                 700                 


Pro Ala Glu Ile Ile Val Asp Gly Val Ser Gly Phe Gln Ile Asp Pro 
705                 710                 715                 720 


Asn Tyr Gly Asp Glu Ser Ser Asn Lys Ile Ala Asp Phe Phe Gln Lys 
                725                 730                 735     


Cys Lys Gln Asp Pro Gly Tyr Trp Asn Arg Ile Ser Asp Gly Gly Leu 
            740                 745                 750         


Met Arg Ile Tyr Glu Cys Tyr Thr Trp Lys Ile Tyr Ala Asn Lys Val 
        755                 760                 765             


Leu Asn Met Gly Asn Ile Tyr Thr Phe Trp Lys Gln Leu Asn Lys Glu 
    770                 775                 780                 


Gln Lys Asp Ala Lys Gln Arg Tyr Ile Glu Leu Phe Tyr Asn Gln His 
785                 790                 795                 800 


Tyr Lys Asn Leu Val Arg Thr Val Pro Ile Val Ser Asp Glu Asp Asp 
                805                 810                 815     


Gln Val Thr Arg Ala Lys Pro Ala Thr Gln Pro Ser Thr Arg Arg Thr 
            820                 825                 830         


Gln Ser Ala Leu Gln Arg Leu Leu Gly Ala 
        835                 840         


<210>  24
<211>  2529
<212>  DNA
<213>  Stevia rebaudiana 

<400>  24
atggcagctt cttcaagtcc cattatgaaa cggtctgagt cagtactcga caccatgcca       60

gaagctttga ggcaaagtcg gtatcatatg aaaaaatgct ttctaaaata tgtagggaaa      120

ggaaagcgga tggtgaaact ccaccatttg atgcaagaaa tggagaccgt cattgaggac      180

aaggacgaaa aggctcagct cttggaaggc ttacttggtt acatcttgtg caccactcag      240

gaagcagcag ttgttcctcc ttatgtcgcc tttgcaataa ggccaaaccc tggattttgg      300

gagtttgtta aagtcaactc taatgatctc tcggttaaag ggatcacttc caccgattac      360

ttgaagttca aggaaatgat cgttgacgaa acatgggcta atgatgaaaa tgcattggag      420

atcgactttg gagcaatgga ctttaacttg ccaacaatga gcttatcttc ttcaattgga      480

aatggagtta acttcacatc aaagtttatt atttctaaac tttatgctca ttctggcagc      540

caattacaat ctctagttga ttacttactt tcattaaatc atcaaggaga aaaacttatg      600

ataaatgaca aactaaacac agtttcaaaa cttcaagccg ctctaatagt agctcattct      660

ttcctttctt cattgcccaa cgacacaccg tatcaaagct ttgaacttag atttaaagag      720

tggggttttg aaaaaggatg gggagattat gcagaaaggg tgcaagaaac aattcggttt      780

ttgttggagg ttcttcaagc acccgacccc gtaaacctag aggccttttt tagcagggtt      840

ccaaacatat tcaatattgt tttattctcg attcatgggt attttggtca atccaatgtt      900

cttggcttgc ccgataccgg aggtcaggta gtttatgttt tggatcaagt tgtggcaatg      960

gaagaagaat tgctacttag gattaagcaa caaggactca gcttcaagcc tcatattctt     1020

gtggtgactc gacttcttcc cgatgccaaa gggaccgagt gtagccaagt tttggaacca     1080

gttctcaaca cgaaacactc acacattctt agagtcccat ttaggacaga aaaaggtgtt     1140

cttcgtaaat gggtgtctcg atttgatatc tatccatacc tcgaaaagtt tactcaggat     1200

gcaagtgcaa aaataactga aatgatggaa ggaaaacctg atcttatcat tggaaactac     1260

actgacggaa acttggttgc atctctcatg gctaacaaac tcggaagcac attgggaacg     1320

attgcacacg cgttagagaa gactaaatac gaagattcag acatgaaatg gaaacatttg     1380

gacacaaaat atcacttttc ttgtcaattt acagctgata tgatagcaat gaattcagca     1440

gatttcatca tcactagtac tttccaagaa attgctggaa gtaaagatag acccggtcag     1500

tatgaaagcc atgaagcatt tacactcccg ggtttatata gagttgtttc gggcatcaac     1560

gtgtttgatc ccaaattcaa cattgcatct ccgggagctg atcaaaccgt ttatttccct     1620

tacacggaaa caccaaaacg attcactact tttcaacccg ctatacaaga attactcttt     1680

agtaaagttg aaaacgacga acacattgga tatttagaag ataagaataa accaatcatc     1740

ttctcaatgg caagactcga catggttaag aacataacgg ggctaaccga atggtttggg     1800

gaaaacaagc ggttaagaag tttggttaat cttgtaattg tggcggggtt ttttgatccg     1860

tcaaaatcaa aagatagaga agaaatggaa gaaataaaga aaatgcattt gttgattgag     1920

aaatatgaac ttaaaggtca aataagatgg atagtagcac aaactgataa aaacagaaat     1980

agtgaacttt atcgttgtat cgctgactca aagggggcgt ttgtgcaacc ggctttatat     2040

gaagcgtttg ggttaaccgt tattgaggct atgaattgtg ggttaccaac ttttgcaact     2100

aaccaaggtg gtccggctga gattattgtt gatggtgttt ctgggttcca aatcgatcct     2160

aattatggcg acgagtctag caacaagatc gctgattttt ttcaaaaatg caaacaggat     2220

ccaggatact ggaataggat ttcagacggt ggtttgatgc gtatatacga atgctacaca     2280

tggaagattt atgcaaataa agtgttgaat atggggaaca tttacacatt ttggaagcag     2340

ttaaacaagg aacagaaaga tgcgaaacaa agatacattg agctattcta caatcaacat     2400

tacaagaatt tggttaggac tgtgccgatt gtaagtgatg aagatgacca agttacaagg     2460

gcaaaaccgg caacacaacc ttcaacaagg cgcacacaat ctgccttgca aaggctgctt     2520

ggagcttaa                                                             2529




<210>  25
<211>  881
<212>  PRT
<213>  Stevia rebaudiana  

<400>  25

Met Asp Phe Gly Ile Ala Glu Thr Leu Ala Glu Ala Leu Lys Gln Asn 
1               5                   10                  15      


Arg Tyr His Ala Arg Arg Cys Phe Glu Arg Phe Thr Ser Arg Gly Lys 
            20                  25                  30          


Arg Met Val Lys Pro Gln Glu Leu Leu His Met Ile Glu Lys Thr Ile 
        35                  40                  45              


Asp Asp Lys Leu Glu Arg Thr Lys Val Leu Glu Gly Ser Met Gly Gln 
    50                  55                  60                  


Ile Leu Ser Ser Thr Gln Glu Ala Ile Val Ile Pro Pro Tyr Val Ile 
65                  70                  75                  80  


Leu Gly Leu Arg Ala Asn Pro Gly Gln Trp Ala Tyr Val Lys Ile Asn 
                85                  90                  95      


Ala Asp Asp Val Thr Val Glu Ser Leu Thr Pro Ser Gln Tyr Leu Lys 
            100                 105                 110         


Phe Lys Glu Ser Ile Tyr Asp Gln Glu Trp Ala Lys Asp Glu Asn Ala 
        115                 120                 125             


Leu Glu Leu Asp Phe Gly Ala Phe Asp Phe Asp Thr Pro Arg Leu Ile 
    130                 135                 140                 


Leu Pro Ser Ser Ile Gly Asn Gly Leu Gly Tyr Ile Ser Lys Phe Met 
145                 150                 155                 160 


Thr Ser Arg Ile Gly Gly Asp Leu Glu Asn Ala Lys Pro Leu Leu Asp 
                165                 170                 175     


His Leu Leu Ala Leu Lys Tyr His Gly Glu Lys Leu Met Ile Asn Glu 
            180                 185                 190         


Thr Ile Asp Thr Val Ser Lys Leu Gln Lys Ala Leu Ile Val Ala Asp 
        195                 200                 205             


Val Tyr Leu Ser Ala His Pro Lys Asp Glu Gln Tyr Gln Thr Leu Glu 
    210                 215                 220                 


Pro Lys Leu Lys Glu Trp Gly Phe Glu Lys Gly Trp Gly Asp Thr Ala 
225                 230                 235                 240 


Glu Arg Val Arg Glu Thr Met Lys Met Leu Ser Glu Ile Leu Gln Ala 
                245                 250                 255     


Pro Asp Pro Ile Asn Met Gln Ser Phe Phe Ser Arg Leu Pro Val Val 
            260                 265                 270         


Phe Asn Ile Val Ile Phe Ser Ile His Gly Tyr Phe Gly Gln Ser Asp 
        275                 280                 285             


Val Leu Gly Leu Pro Asp Thr Gly Gly Gln Val Val Tyr Ile Leu Asp 
    290                 295                 300                 


Gln Val Lys Ala Leu Glu Glu Glu Ile Leu Leu Arg Ile Lys Met Gln 
305                 310                 315                 320 


Gly Leu Asn Ala Lys Pro Arg Ile Leu Val Val Ser Arg Leu Ile Pro 
                325                 330                 335     


Asp Ala Gln Gly Thr Lys Cys Asn Glu Glu Met Glu Pro Ile Leu Asn 
            340                 345                 350         


Thr Met His Ser His Ile Leu Arg Val Pro Phe Arg Thr Ser Lys Gly 
        355                 360                 365             


Val Val Pro Gln Trp Val Ser Arg Phe Asp Ile Tyr Pro Tyr Leu Glu 
    370                 375                 380                 


Arg Phe Ser Gln Asp Ala Ala Ser Lys Ile Leu Glu Val Met Glu Cys 
385                 390                 395                 400 


Lys Pro Asp Leu Ile Leu Gly Asn Tyr Thr Asp Gly Asn Ile Val Ala 
                405                 410                 415     


Ser Leu Ile Ala Lys Lys Phe Gly Val Thr Gln Gly Thr Ile Ala His 
            420                 425                 430         


Ala Leu Glu Lys Thr Lys Tyr Glu Asp Ser Asp Val Asn Trp Lys Asn 
        435                 440                 445             


Phe Glu Lys Lys Tyr His Phe Ser Cys Gln Phe Thr Ala Asp Leu Ile 
    450                 455                 460                 


Ser Met Asn Ala Ala Asp Phe Ile Ile Thr Ser Thr Tyr Gln Glu Ile 
465                 470                 475                 480 


Val Gly Ser Lys Gln Arg Pro Gly Gln Tyr Glu Thr His Gly Ala Phe 
                485                 490                 495     


Ser Met Pro Gly Leu Cys Arg Val Val Ser Gly Ile Asn Val Phe Asp 
            500                 505                 510         


Pro Lys Phe Asn Ile Ala Ser Pro Gly Ala Glu Gln Ser Val Tyr Phe 
        515                 520                 525             


Pro Tyr Thr Glu Lys Glu Lys Arg Leu Thr Asp Phe His Pro Ala Ile 
    530                 535                 540                 


Lys Glu Leu Leu Phe Asn Glu Gln Asp Asn Asp Glu His Met Gly Tyr 
545                 550                 555                 560 


Leu Ala Asp Val Thr Lys Pro Ile Ile Phe Ser Met Ala Arg Leu Asp 
                565                 570                 575     


Thr Val Lys Asn Ile Thr Gly Leu Thr Glu Trp Phe Gly Lys Asn Lys 
            580                 585                 590         


Arg Leu Arg Ser Leu Val Asn Leu Val Val Val Ala Gly Phe Phe Asp 
        595                 600                 605             


Pro Ser Lys Ser Lys Asp Arg Glu Glu Met Glu Glu Ile Lys Lys Met 
    610                 615                 620                 


His Glu Leu Ile Glu Lys Tyr Lys Leu Lys Gly Gln Met Arg Trp Ile 
625                 630                 635                 640 


Ala Ala Gln Asn Asp Arg Thr Arg Asn Gly Glu Leu Tyr Arg Cys Ile 
                645                 650                 655     


Ser Asp Thr Lys Gly Ala Phe Val Gln Pro Ala Leu Tyr Glu Ala Phe 
            660                 665                 670         


Gly Leu Thr Val Ile Glu Ala Met Asn Cys Gly Leu Pro Thr Phe Ala 
        675                 680                 685             


Thr Asn Gln Gly Gly Pro Ala Glu Ile Ile Val Asp Gly Val Ser Gly 
    690                 695                 700                 


Phe His Ile Asp Pro Val Asn Gly Asp Glu Ser Ser Asn Lys Ile Ala 
705                 710                 715                 720 


Asp Phe Phe Thr Lys Cys Lys Val Asp Gly Glu Tyr Trp Asp Arg Val 
                725                 730                 735     


Ser Gln Ala Gly Leu Gln Arg Ile Tyr Glu Cys Tyr Thr Trp Lys Met 
            740                 745                 750         


Tyr Ala Asn Lys Ala Leu Asn Met Gly Ser Met Tyr Gly Phe Trp Arg 
        755                 760                 765             


Gln Leu Asn Lys Glu Thr Lys Gln Ala Lys Gln Arg Tyr Ile Asp Ile 
    770                 775                 780                 


Leu Tyr Asn Leu Gln Phe Lys Asn Leu Ala Lys Thr Ile Glu Ile Pro 
785                 790                 795                 800 


Asp Phe Val Thr Pro Lys Leu Gln Glu Pro Val Lys Thr Glu Pro Thr 
                805                 810                 815     


Lys Pro Leu Gln Glu Ala Arg Pro Arg Glu Pro Val Gln Lys Leu Val 
            820                 825                 830         


Pro Glu Glu Thr Arg Leu Pro Lys Leu Glu Leu Thr Lys Leu Gly Gln 
        835                 840                 845             


Pro Asn Leu Met Ser Asn Ala Arg Lys Pro Leu Ile Val Leu Val Ser 
    850                 855                 860                 


Val Leu Ile Val Ala Tyr Ala Ser Lys Asn Leu Tyr Arg Arg Tyr Phe 
865                 870                 875                 880 


Lys 
    


<210>  26
<211>  2646
<212>  DNA
<213>  Stevia rebaudiana  

<400>  26
atggatttcg gtatagcaga gactttggcc gaggcattga agcaaaaccg gtaccatgca       60

aggagatgct ttgagcgttt tacatcacgt ggaaaaagga tggtgaagcc tcaagagtta      120

ttacacatga ttgaaaaaac cattgacgac aagcttgaaa gaacgaaggt cttggagggc      180

tcaatgggac aaatcttgag ttccacacag gaggcaatcg ttattccacc atatgttatt      240

ttaggattga gagcgaatcc aggacaatgg gcatacgtta agatcaatgc tgatgacgtc      300

actgttgagt cactcacacc ttcacaatat ctaaagttca aagaatccat ctacgatcaa      360

gaatgggcaa aggacgaaaa tgcccttgaa ctagatttcg gagcgttcga ctttgatacg      420

cctcgattaa tcctcccgtc atctatcggc aacggactcg gttacatttc aaagttcatg      480

acttcaagaa ttggtggtga tctagaaaac gcgaagccgt tgcttgacca cttgcttgct      540

ctaaaatatc atggagagaa gcttatgatc aatgagacaa tagatacagt ttcaaagctc      600

cagaaagcat taattgttgc tgatgtctac ttatctgcac acccgaaaga cgaacaatat      660

caaaccttag agcccaagct taaagaatgg ggatttgaga aaggatgggg agatactgct      720

gaaagagtta gagagacaat gaaaatgctt tcggagattc ttcaagcacc cgacccgatt      780

aacatgcaat cgttctttag caggcttccg gtggtcttca atattgtcat attttctatt      840

catgggtatt ttggtcaatc agatgttctt ggattacctg ataccggagg gcaggttgtt      900

tacattcttg atcaagttaa agcattagag gaagagatat tgctaagaat aaaaatgcaa      960

ggattgaatg caaagcctcg gattcttgtg gtgagtcgac tcattcccga cgcacaagga     1020

acaaagtgta acgaggaaat ggaaccgatc ttgaacacaa tgcattcaca catccttcgg     1080

gttcctttca gaacctcaaa aggcgttgtt cctcaatggg tatcgcggtt tgacatctac     1140

ccgtatcttg aaagattctc acaggacgct gcctctaaaa tacttgaagt aatggaatgt     1200

aaaccagatc tcatacttgg aaactacaca gatggaaaca ttgttgcatc acttatagcc     1260

aaaaagtttg gagtaacaca ggggacgatt gcacacgcgt tagagaagac aaagtacgaa     1320

gattcggatg ttaactggaa aaactttgaa aaaaagtatc atttctcatg tcaatttacc     1380

gcggatttga tctcaatgaa cgctgcagat ttcataatca caagcactta tcaagaaatt     1440

gtgggaagca aacaaagacc cggacagtat gagacccacg gggcgtttag tatgcccgga     1500

ctttgtagag tcgtgtcggg catcaacgtg tttgatccta agttcaacat tgcttcaccc     1560

ggtgcggaac aatcggttta ttttccgtac accgagaagg agaaacggtt aacggatttt     1620

catcccgcaa ttaaagaact acttttcaac gaacaagaca atgacgagca tatgggatac     1680

ctcgcggatg taaccaaacc gataatattc tcaatggcga ggctcgatac ggtgaagaac     1740

ataacagggt taaccgagtg gttcggtaag aacaaacgac ttagaagtct tgtaaacttg     1800

gttgttgtcg cggggttctt cgatccatca aaatctaaag accgtgaaga gatggaggaa     1860

atcaagaaaa tgcatgaact aatagagaaa tacaaactca agggtcagat gagatggatc     1920

gcggctcaaa acgataggac ccgcaatggt gaattgtatc ggtgtatttc cgatacgaag     1980

ggagcgtttg tgcagcccgc gttgtatgag gcttttgggc tcacggttat cgaggcaatg     2040

aactgcggtc tcccgacttt tgcaaccaat caaggcgggc ccgcggagat catagttgac     2100

ggagtttcgg gatttcatat tgatcccgtt aacggagatg aatcaagcaa caagattgct     2160

gatttcttca cgaaatgcaa agtcgatggc gagtattggg accgcgtgtc gcaagcggga     2220

cttcaacgta tttacgagtg ctacacatgg aagatgtatg ctaacaaagc attgaacatg     2280

ggttcgatgt atggtttttg gaggcaatta aacaaagaaa ctaagcaagc gaagcaacga     2340

tacatcgata tcttgtataa cttacaattc aagaatttgg caaaaaccat tgaaatccct     2400

gattttgtga ctcctaaact tcaagaaccg gtcaaaaccg aaccaacaaa accattacaa     2460

gaagcaagac ctcgagaacc ggtgcaaaaa ctggtaccgg aagaaacccg actgccaaaa     2520

ctagagttga ccaagcttgg tcaaccgaat ttgatgagca atgcaagaaa accattgatt     2580

gttcttgttt ctgtgttgat agttgcatat gcatccaaga acttgtatag gaggtatttc     2640

aaatag                                                                2646


<210>  27
<211>  458
<212>  PRT
<213>  Stevia rebaudiana  

<400>  27

Met Glu Asn Lys Thr Glu Thr Thr Val Arg Arg Arg Arg Arg Ile Ile 
1               5                   10                  15      


Leu Phe Pro Val Pro Val Gln Gly His Ile Asn Pro Ile Leu Gln Leu 
            20                  25                  30          


Ala Asn Val Leu Tyr Ser Lys Gly Phe Ser Ile Thr Ile Phe His Thr 
        35                  40                  45              


Asn Phe Asn Lys Pro Lys Thr Ser Asn Tyr Pro His Phe Thr Phe Arg 
    50                  55                  60                  


Phe Ile Leu Asp Asn Asp Pro Gln Asp Val Arg Ile Ser Asn Leu Pro 
65                  70                  75                  80  


Thr His Gly Pro Leu Thr Val Met Arg Ile Leu Ile Ile Asn Glu His 
                85                  90                  95      


Gly Ala Asp Glu Leu Gln Arg Glu Leu Glu Leu Leu Met Leu Ala Ser 
            100                 105                 110         


Glu Glu Asp Gly Glu Val Ser Cys Leu Ile Thr Asp Gln Ile Trp Tyr 
        115                 120                 125             


Phe Thr Gln Ser Val Ala Asp Ser Leu Asn Leu Arg Arg Leu Val Leu 
    130                 135                 140                 


Met Thr Ser Ser Leu Phe Asn Phe His Ala His Val Ser Leu Pro Gln 
145                 150                 155                 160 


Phe Asp Glu Leu Gly Tyr Leu Asp Pro Asp Asp Lys Thr Arg Leu Glu 
                165                 170                 175     


Glu Gln Ala Ser Gly Phe Pro Met Leu Lys Val Lys Asp Ile Lys Cys 
            180                 185                 190         


Gly Phe Ser Met Trp Lys Gln Gly Lys Glu Ile Phe Glu Asn Ile Thr 
        195                 200                 205             


Lys Gln Thr Lys Ala Ser Ser Gly Val Ile Trp Asn Ser Phe Lys Glu 
    210                 215                 220                 


Leu Glu Glu Ser Glu Leu Glu Thr Val Ile Arg Glu Ile Pro Ala Pro 
225                 230                 235                 240 


Ser Phe Leu Ile Pro Leu Pro Lys His Leu Thr Ala Ser Ser Ser Ser 
                245                 250                 255     


Leu Leu Asp His Asp Arg Thr Val Phe Pro Trp Leu Asp Gln Gln Pro 
            260                 265                 270         


Ser Arg Ser Val Leu Tyr Val Ser Phe Gly Ser Ala Thr Glu Val Asp 
        275                 280                 285             


Ala Lys Asp Phe Leu Glu Ile Ala Arg Gly Leu Val Asp Ser Lys Gln 
    290                 295                 300                 


Ser Phe Leu Trp Val Val Arg Pro Gly Phe Val Lys Gly Ser Thr Trp 
305                 310                 315                 320 


Val Glu Pro Leu Pro Asp Gly Phe Leu Gly Glu Arg Gly Arg Ile Val 
                325                 330                 335     


Lys Trp Val Pro Gln Gln Glu Val Leu Ala His Gly Ala Ile Gly Ala 
            340                 345                 350         


Phe Trp Thr His Ser Gly Trp Asn Ser Thr Leu Glu Ser Val Cys Glu 
        355                 360                 365             


Gly Val Pro Met Ile Phe Ser Ala Phe Ala Phe Asp Gln Pro Leu Asn 
    370                 375                 380                 


Ala Arg Tyr Met Ser Asp Val Leu Lys Val Gly Val Tyr Leu Glu Asn 
385                 390                 395                 400 


Gly Trp Glu Arg Gly Glu Ile Ala Asn Ala Ile Arg Arg Val Met Val 
                405                 410                 415     


Asp Glu Glu Gly Gly Tyr Ile Arg Gln Asn Ala Ser Val Leu Lys Gln 
            420                 425                 430         


Lys Ala Asp Val Ser Leu Met Lys Gly Gly Ser Ser Tyr Glu Ser Leu 
        435                 440                 445             


Glu Ser Leu Val Ala Tyr Ile Ser Ser Leu 
    450                 455             


<210>  28
<211>  1377
<212>  DNA
<213> Stevia rebaudiana  

<400>  28
atggaaaata aaacggagac caccgttcgc cggcgccgga gaataatatt attcccggta       60

ccagttcaag gccacattaa cccaattctt cagctagcca atgtgttgta ctccaaagga      120

ttcagtatca ccatctttca caccaacttc aacaaaccca aaacatctaa ttaccctcac      180

ttcactttca gattcatcct cgacaacgac ccacaagacg tacgcatttc caatctaccg      240

actcatggtc cgctcactgt tatgcggatt ctgattatca acgaacacgg agctgacgaa      300

ttacaacgcg aactggaact gttgatgtta gcttctgaag aagatggaga ggtatcgtgt      360

ttaatcaccg atcagatttg gtacttcacg caatctgttg ctgacagtct taacctccga      420

cggcttgttt tgatgacaag cagcttgttt aattttcatg cacatgtttc acttcctcag      480

tttgatgagc ttggttacct cgatcctgat gacaaaaccc gtttggaaga acaagcgagt      540

gggtttccta tgctgaaagt gaaagatatc aagtgtggtt tttcgatgtg gaaacaaggc      600

aaagagatat tcgagaacat tacgaaacaa acaaaagcat cttcaggagt catctggaac      660

tcatttaagg aactcgaaga gtctgagctc gaaactgtta tccgtgagat cccggctcca      720

agtttcttga taccactccc caagcatttg acagcctctt ccagcagctt actagaccac      780

gatcgaaccg tttttccatg gttagaccaa caaccgtcac gttcggtact gtatgttagt      840

tttggtagtg ctactgaagt ggatgcgaaa gatttcttgg aaatagctcg tgggttggtt      900

gatagcaagc agtcgttttt atgggtggtt cgacctggtt ttgtcaaggg ttcgacgtgg      960

gtcgaaccgt tgccagatgg gttcttgggt gaaagaggac gtattgtgaa atgggttccg     1020

cagcaagaag tgctagctca tggagcaata ggcgcattct ggactcatag cggatggaac     1080

tctacgttgg aaagcgtttg tgaaggtgtt cctatgattt tctcggcttt tgcgttcgat     1140

caaccgttga atgctagata catgagtgat gttttgaagg taggggtgta tttggaaaat     1200

gggtgggaaa gaggagagat agcaaatgca ataagaagag ttatggtgga tgaagaagga     1260

ggatacatta gacagaatgc aagtgttttg aaacaaaagg cagatgtttc tttgatgaag     1320

ggtggttcgt cttacgaatc attagagtct ctagttgctt acatttcatc gttgtaa        1377


<210>  29
<211>  424
<212>  PRT
<213>  Stevia rebaudiana  

<400>  29

Met Leu Gln Leu Ala Thr Tyr Leu His Ser Gln Gly Ile Ser Ile Thr 
1               5                   10                  15      


Ile Ala Gln Tyr Pro Asn Phe Asn Ser Pro Asp Ser Ser Asn His Pro 
            20                  25                  30          


Glu Leu Thr Phe Leu Pro Leu Ser Ser Gly Asn Leu Ser Val Ala Asp 
        35                  40                  45              


Ile Ser Gly Gly Phe Phe Lys Phe Ile Gln Thr Leu Asn His Asn Cys 
    50                  55                  60                  


Lys Pro His Phe Arg Glu Tyr Leu Val Gln Asn Met Ser Ser Asp Asp 
65                  70                  75                  80  


Lys Glu Ser Ile Val Ile Ile Arg Asp Asn Leu Met Phe Phe Ala Gly 
                85                  90                  95      


Glu Ile Ala Gly Glu Leu Gly Leu Pro Ser Ile Ile Leu Arg Gly Ser 
            100                 105                 110         


Asn Ala Val Met Leu Thr Ala Ser Asp Ile Ile Pro Gln Leu His Gln 
        115                 120                 125             


Glu Gly Arg Phe Pro Pro Pro Asp Ser Leu Leu Gln Glu Thr Ile Pro 
    130                 135                 140                 


Glu Leu Val Pro Phe Arg Tyr Lys Asp Leu Pro Phe Ile Gly Tyr Pro 
145                 150                 155                 160 


Ile His Gln Thr Leu Glu Phe Ser Ile Thr Met Met Thr Pro Lys Ser 
                165                 170                 175     


Pro Ala Ser Ala Ile Leu Ile Asn Thr Leu Glu Phe Leu Glu Gln Ser 
            180                 185                 190         


Ala Leu Thr Gln Ile Arg Asp His Tyr Lys Val Pro Val Phe Thr Ile 
        195                 200                 205             


Gly Pro Leu His Lys Ile Val Thr Thr Arg Ser Thr Ser Ile Leu Glu 
    210                 215                 220                 


Glu Asp Thr Ser Cys Ile Asn Trp Leu Asp Lys Gln Ser Pro Lys Ser 
225                 230                 235                 240 


Val Val Tyr Val Ser Leu Gly Ser Leu Ala Lys Leu Asp Glu Lys Val 
                245                 250                 255     


Ala Ser Glu Met Ala Cys Gly Leu Ala Met Ser Asn His Lys Phe Leu 
            260                 265                 270         


Trp Val Val Arg Pro Gly Met Val His Gly Phe Glu Trp Val Glu Phe 
        275                 280                 285             


Leu Pro Asp Ser Leu Val Gly Glu Met Lys Ala Arg Gly Leu Ile Val 
    290                 295                 300                 


Lys Trp Ala Pro Gln Thr Thr Val Leu Ala His Asn Ala Val Gly Gly 
305                 310                 315                 320 


Phe Trp Ser His Cys Gly Trp Asn Ser Thr Ile Glu Cys Leu Ala Glu 
                325                 330                 335     


Gly Val Pro Met Met Cys Gln Pro Phe Phe Ala Asp Gln Leu Leu Asn 
            340                 345                 350         


Ala Arg Tyr Val Ser Asp Val Trp Lys Thr Gly Phe Glu Ile Val Ile 
        355                 360                 365             


Glu Lys Gly Glu Ile Ala Cys Ala Ile Lys Arg Val Leu Val Asp Glu 
    370                 375                 380                 


Glu Gly Glu Glu Met Arg Gln Arg Ala Met Glu Ile Lys Glu Lys Val 
385                 390                 395                 400 


Lys Ile Ala Ile Asn Asp Gly Gly Ser Ser Tyr Asp Ser Phe Lys Asp 
                405                 410                 415     


Leu Val Ala Phe Ile Ser Ser Leu 
            420                 


<210>  30
<211>  1275
<212>  DNA
<213>  Stevia rebaudiana

<400>  30
atgcttcagc ttgcaactta cctccattct caagggattt caataaccat cgctcagtac       60

cccaacttca actcgccgga ttcttccaac catccagaac taaccttcct cccactatcc      120

tccggcaact tatccgtcgc cgacatctcc ggcggctttt tcaagttcat ccaaactctt      180

aaccataact gcaaacccca tttccgggaa taccttgttc agaacatgag ttctgatgat      240

aaggaatcaa tcgttatcat ccgtgataat ctcatgtttt tcgccggaga aatcgccggc      300

gagctgggtc tgccttcgat cattttacgt ggcagcaatg ctgtcatgtt gactgctagc      360

gacatcatcc ctcaacttca tcaagaaggt cgttttccgc caccagattc tttgttgcag      420

gaaacaattc cagaactggt tccattcaga tacaaagatc taccatttat tggctatcca      480

atacatcaaa cccttgaatt tagtatcacc atgatgaccc ccaaatcacc tgcttccgcc      540

attcttatca acaccctcga atttcttgaa caatcggcat taacccagat ccgtgatcat      600

tacaaagttc cagtttttac aatcggacca ttgcacaaaa tagtcacaac tcgttccact      660

agcattcttg aagaagatac aagttgcatc aattggttag ataaacaatc acccaaatca      720

gtggtttatg tgagtttagg aagcttagca aagttggatg aaaaggttgc atctgaaatg      780

gcatgtggtt tagccatgag taaccataag ttcctatggg tggttcgacc cggtatggtt      840

catgggtttg aatgggtcga gtttttgccg gatagtttgg tgggtgaaat gaaggctaga      900

ggtttgattg tgaaatgggc accccagacg acggttttgg cgcataacgc ggttggtgga      960

ttttggagtc attgcggttg gaactcgacc atagaatgct tagctgaagg ggtcccgatg     1020

atgtgtcaac cgttttttgc tgatcagttg ttgaatgcta ggtatgtgag tgatgtttgg     1080

aagacgggtt ttgagattgt tatcgagaaa ggtgagattg cgtgcgcgat taaacgagtt     1140

ttggtggatg aagaaggcga agaaatgagg cagagagcta tggagattaa agaaaaggtt     1200

aaaattgcaa tcaacgatgg tggttcttct tatgactcgt tcaaggactt ggtggcgttt     1260

atttcatcac tctaa                                                      1275


<210>  31
<211>  485
<212>  PRT
<213>  Stevia rebaudiana  

<400>  31

Met Tyr Asn Val Thr Tyr His Gln Asn Ser Lys Ala Met Ala Thr Ser 
1               5                   10                  15      


Asp Ser Ile Val Asp Asp Arg Lys Gln Leu His Val Ala Thr Phe Pro 
            20                  25                  30          


Trp Leu Ala Phe Gly His Ile Leu Pro Phe Leu Gln Leu Ser Lys Leu 
        35                  40                  45              


Ile Ala Glu Lys Gly His Lys Val Ser Phe Leu Ser Thr Thr Arg Asn 
    50                  55                  60                  


Ile Gln Arg Leu Ser Ser His Ile Ser Pro Leu Ile Asn Val Val Gln 
65                  70                  75                  80  


Leu Thr Leu Pro Arg Val Gln Glu Leu Pro Glu Asp Ala Glu Ala Thr 
                85                  90                  95      


Thr Asp Val His Pro Glu Asp Ile Gln Tyr Leu Lys Lys Ala Val Asp 
            100                 105                 110         


Gly Leu Gln Pro Glu Val Thr Arg Phe Leu Glu Gln His Ser Pro Asp 
        115                 120                 125             


Trp Ile Ile Tyr Asp Phe Thr His Tyr Trp Leu Pro Ser Ile Ala Ala 
    130                 135                 140                 


Ser Leu Gly Ile Ser Arg Ala Tyr Phe Cys Val Ile Thr Pro Trp Thr 
145                 150                 155                 160 


Ile Ala Tyr Leu Ala Pro Ser Ser Asp Ala Met Ile Asn Asp Ser Asp 
                165                 170                 175     


Gly Arg Thr Thr Val Glu Asp Leu Thr Thr Pro Pro Lys Trp Phe Pro 
            180                 185                 190         


Phe Pro Thr Lys Val Cys Trp Arg Lys His Asp Leu Ala Arg Met Glu 
        195                 200                 205             


Pro Tyr Glu Ala Pro Gly Ile Ser Asp Gly Tyr Arg Met Gly Met Val 
    210                 215                 220                 


Phe Lys Gly Ser Asp Cys Leu Leu Phe Lys Cys Tyr His Glu Phe Gly 
225                 230                 235                 240 


Thr Gln Trp Leu Pro Leu Leu Glu Thr Leu His Gln Val Pro Val Val 
                245                 250                 255     


Pro Val Gly Leu Leu Pro Pro Glu Ile Pro Gly Asp Glu Lys Asp Glu 
            260                 265                 270         


Thr Trp Val Ser Ile Lys Lys Trp Leu Asp Gly Lys Gln Lys Gly Ser 
        275                 280                 285             


Val Val Tyr Val Ala Leu Gly Ser Glu Ala Leu Val Ser Gln Thr Glu 
    290                 295                 300                 


Val Val Glu Leu Ala Leu Gly Leu Glu Leu Ser Gly Leu Pro Phe Val 
305                 310                 315                 320 


Trp Ala Tyr Arg Lys Pro Lys Gly Pro Ala Lys Ser Asp Ser Val Glu 
                325                 330                 335     


Leu Pro Asp Gly Phe Val Glu Arg Thr Arg Asp Arg Gly Leu Val Trp 
            340                 345                 350         


Thr Ser Trp Ala Pro Gln Leu Arg Ile Leu Ser His Glu Ser Val Cys 
        355                 360                 365             


Gly Phe Leu Thr His Cys Gly Ser Gly Ser Ile Val Glu Gly Leu Met 
    370                 375                 380                 


Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Cys Asp Gln Pro Leu 
385                 390                 395                 400 


Asn Ala Arg Leu Leu Glu Asp Lys Gln Val Gly Ile Glu Ile Pro Arg 
                405                 410                 415     


Asn Glu Glu Asp Gly Cys Leu Thr Lys Glu Ser Val Ala Arg Ser Leu 
            420                 425                 430         


Arg Ser Val Val Val Glu Asn Glu Gly Glu Ile Tyr Lys Ala Asn Ala 
        435                 440                 445             


Arg Ala Leu Ser Lys Ile Tyr Asn Asp Thr Lys Val Glu Lys Glu Tyr 
    450                 455                 460                 


Val Ser Gln Phe Val Asp Tyr Leu Glu Lys Asn Ala Arg Ala Val Ala 
465                 470                 475                 480 


Ile Asp His Glu Ser 
                485 


<210>  32
<211>  1458
<212>  DNA
<213>  Stevia rebaudiana
<220>

<400>  32
atgtacaacg ttacttatca tcaaaattca aaagcaatgg ctaccagtga ctccatagtt       60

gacgaccgta agcagcttca tgttgcgacg ttcccatggc ttgctttcgg tcacatcctc      120

cctttccttc agctttcgaa attgatagct gaaaagggtc acaaagtctc gtttctttct      180

accaccagaa acattcaacg tctctcttct catatctcgc cactcataaa tgttgttcaa      240

ctcacacttc cacgtgtcca agagctgccg gaggatgcag aggcgaccac tgacgtccac      300

cctgaagata ttcaatatct caagaaggct gttgatggtc ttcaaccgga ggtcacccgg      360

tttctagaac aacactctcc ggactggatt atttatgatt ttactcacta ctggttgcca      420

tccatcgcgg ctagcctcgg tatctcacga gcctacttct gcgtcatcac tccatggacc      480

attgcttatt tggcaccctc atctgacgcc atgataaatg attcagatgg tcgaaccacg      540

gttgaggatc tcacgacacc gcccaagtgg tttccctttc cgaccaaagt atgctggcgg      600

aagcatgatc ttgcccgaat ggagccttac gaagctccgg ggatatctga tggataccgt      660

atggggatgg tttttaaggg atctgattgt ttgcttttca aatgttacca tgagtttgga      720

actcaatggc tacctctttt ggagacacta caccaagtac cggtggttcc ggtgggatta      780

ctgccgccgg aaatacccgg agacgagaaa gatgaaacat gggtgtcaat caagaaatgg      840

ctcgatggta aacaaaaagg cagtgtggtg tacgttgcat taggaagcga ggctttggtg      900

agccaaaccg aggttgttga gttagcattg ggtctcgagc tttctgggtt gccatttgtt      960

tgggcttata gaaaaccaaa aggtcccgcg aagtcagact cggtggagtt gccagacggg     1020

ttcgtggaac gaactcgtga ccgtgggttg gtctggacga gttgggcacc tcagttacga     1080

atactgagcc acgagtcagt ttgtggtttc ttgactcatt gtggttctgg atcaattgtg     1140

gaagggctaa tgtttggtca ccctctaatc atgctaccga ttttttgtga ccaacctctg     1200

aatgctcgat tactggagga caaacaggtg ggaatcgaga taccaagaaa tgaggaagat     1260

ggttgcttga ccaaggagtc ggttgctaga tcactgaggt ccgttgttgt ggaaaacgaa     1320

ggggagatct acaaggcgaa cgcgagggcg ctgagtaaaa tctataacga cactaaggtg     1380

gaaaaagaat atgtaagcca attcgtagac tatttggaaa agaatgcgcg tgcggttgcc     1440

atcgatcatg agagttaa                                                   1458


<210>  33
<211>  473
<212>  PRT
<213>  Stevia rebaudiana

<400>  33

Met Ala Thr Ser Asp Ser Ile Val Asp Asp Arg Lys Gln Leu His Val 
1               5                   10                  15      


Ala Thr Phe Pro Trp Leu Ala Phe Gly His Ile Leu Pro Tyr Leu Gln 
            20                  25                  30          


Leu Ser Lys Leu Ile Ala Glu Lys Gly His Lys Val Ser Phe Leu Ser 
        35                  40                  45              


Thr Thr Arg Asn Ile Gln Arg Leu Ser Ser His Ile Ser Pro Leu Ile 
    50                  55                  60                  


Asn Val Val Gln Leu Thr Leu Pro Arg Val Gln Glu Leu Pro Glu Asp 
65                  70                  75                  80  


Ala Glu Ala Thr Thr Asp Val His Pro Glu Asp Ile Pro Tyr Leu Lys 
                85                  90                  95      


Lys Ala Ser Asp Gly Leu Gln Pro Glu Val Thr Arg Phe Leu Glu Gln 
            100                 105                 110         


His Ser Pro Asp Trp Ile Ile Tyr Asp Tyr Thr His Tyr Trp Leu Pro 
        115                 120                 125             


Ser Ile Ala Ala Ser Leu Gly Ile Ser Arg Ala His Phe Ser Val Thr 
    130                 135                 140                 


Thr Pro Trp Ala Ile Ala Tyr Met Gly Pro Ser Ala Asp Ala Met Ile 
145                 150                 155                 160 


Asn Gly Ser Asp Gly Arg Thr Thr Val Glu Asp Leu Thr Thr Pro Pro 
                165                 170                 175     


Lys Trp Phe Pro Phe Pro Thr Lys Val Cys Trp Arg Lys His Asp Leu 
            180                 185                 190         


Ala Arg Leu Val Pro Tyr Lys Ala Pro Gly Ile Ser Asp Gly Tyr Arg 
        195                 200                 205             


Met Gly Leu Val Leu Lys Gly Ser Asp Cys Leu Leu Ser Lys Cys Tyr 
    210                 215                 220                 


His Glu Phe Gly Thr Gln Trp Leu Pro Leu Leu Glu Thr Leu His Gln 
225                 230                 235                 240 


Val Pro Val Val Pro Val Gly Leu Leu Pro Pro Glu Ile Pro Gly Asp 
                245                 250                 255     


Glu Lys Asp Glu Thr Trp Val Ser Ile Lys Lys Trp Leu Asp Gly Lys 
            260                 265                 270         


Gln Lys Gly Ser Val Val Tyr Val Ala Leu Gly Ser Glu Val Leu Val 
        275                 280                 285             


Ser Gln Thr Glu Val Val Glu Leu Ala Leu Gly Leu Glu Leu Ser Gly 
    290                 295                 300                 


Leu Pro Phe Val Trp Ala Tyr Arg Lys Pro Lys Gly Pro Ala Lys Ser 
305                 310                 315                 320 


Asp Ser Val Glu Leu Pro Asp Gly Phe Val Glu Arg Thr Arg Asp Arg 
                325                 330                 335     


Gly Leu Val Trp Thr Ser Trp Ala Pro Gln Leu Arg Ile Leu Ser His 
            340                 345                 350         


Glu Ser Val Cys Gly Phe Leu Thr His Cys Gly Ser Gly Ser Ile Val 
        355                 360                 365             


Glu Gly Leu Met Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Gly 
    370                 375                 380                 


Asp Gln Pro Leu Asn Ala Arg Leu Leu Glu Asp Lys Gln Val Gly Ile 
385                 390                 395                 400 


Glu Ile Pro Arg Asn Glu Glu Asp Gly Cys Leu Thr Lys Glu Ser Val 
                405                 410                 415     


Ala Arg Ser Leu Arg Ser Val Val Val Glu Lys Glu Gly Glu Ile Tyr 
            420                 425                 430         


Lys Ala Asn Ala Arg Glu Leu Ser Lys Ile Tyr Asn Asp Thr Lys Val 
        435                 440                 445             


Glu Lys Glu Tyr Val Ser Gln Phe Val Asp Tyr Leu Glu Lys Asn Ala 
    450                 455                 460                 


Arg Ala Val Ala Ile Asp His Glu Ser 
465                 470             


<210>  34
<211>  1422
<212>  DNA
<213>  Stevia rebaudiana 

<400>  34
atggccacat ctgactctat cgttgatgac agaaaacaat tgcatgttgc tactttccca       60

tggttggcct ttggacacat tctgccctac ttgcaattgt caaagctgat tgcagaaaaa      120

ggtcataagg tgtccttttt gtctaccaca agaaacatcc agagactaag ttctcatatt      180

tctccattga ttaatgtggt tcagttgacc ttgcctagag tccaagaact tcccgaagac      240

gcagaagcta ctactgatgt tcaccctgaa gatatcccat atctaaagaa ggcatctgat      300

ggacttcaac cagaagtaac caggtttttg gagcagcaca gtcctgactg gattatctat      360

gattatactc attactggct tccatccatc gcagctagtc taggcatttc cagagctcat      420

ttctctgtca ctaccccatg ggcaattgca tatatgggtc cttctgctga tgcaatgatc      480

aacggttctg atggtaggac cactgttgaa gatttaacta cacctccaaa gtggttccca      540

tttcctacta aagtttgttg gcgaaaacac gatctggcac gtttggtccc atataaggct      600

ccaggtatct ccgatggata tcgaatgggt ctggtgctaa agggttctga ttgtctgtta      660

tctaagtgtt accacgaatt tggaactcaa tggcttcctc tattagagac tctgcatcaa      720

gttccagttg ttcctgtcgg tctgctacca cctgaaattc ccggtgacga aaaggacgaa      780

acttgggttt ccataaaaaa atggctggat ggtaagcaga agggtagtgt tgtatatgtc      840

gctttaggct ccgaggtttt ggtatcccag actgaagttg tggaacttgc cttaggattg      900

gagttgtccg gtttgccatt cgtctgggca tatagaaagc caaagggacc agctaagtca      960

gactcagttg aattgccaga tggtttcgta gaaaggacaa gagacagagg attggtttgg     1020

acatcatggg ccccacaatt gagaattctg agtcatgaaa gtgtgtgtgg attcttgact     1080

cactgtggct ctggcagtat tgttgaagga ctgatgtttg gacacccact gataatgttg     1140

ccaatcttcg gtgaccaacc tctgaatgca agattgctgg aggataaaca agttggtatc     1200

gaaatcccaa gaaacgagga agacggctgc ctgactaagg aatcagttgc acgtagttta     1260

agatctgtag ttgttgaaaa agaaggtgaa atatataagg ctaacgctag agaactttca     1320

aagatataca atgataccaa ggtggagaaa gaatatgttt cacagtttgt ggactatttg     1380

gagaaaaacg ctagagccgt tgctatcgat cacgaatcat ag                        1422


