                         SEQUENCE LISTING

<110>  APTEVO RESEARCH AND DEVELOPMENT LLC
       Tan, Philip
       Blankenship, John W.
 
<120>  CD3 BINDING POLYPEPTIDES

<130>  APVO-052/01WO

<150>  US 62/221,190
<151>  2015-09-21

<160>  222   

<170>  PatentIn version 3.5

<210>  1
<211>  1560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc DRA222 (TSC311 or TSC312) CD3-binding domain

<400>  1
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt ggagtctggg      840

ggcggagtgg tgcagcctgg gcggtcactg aggctgtcct gcaaggcttc tggctacacc      900

tttactagat ctacgatgca ctgggtaagg caggcccctg gacaaggtct ggaatggatt      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacaggttc     1020

acaatcagcg cagacaaatc caagagcaca gccttcctgc agatggacag cctgaggccc     1080

gaggacaccg gcgtctattt ctgtgcacgg ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaagggac tcccgtcact gtctctagcg gtggcggagg gtctgggggt     1200

ggcggatccg gaggtggtgg ctctgcacaa gacatccaga tgacccagtc tccaagcagc     1260

ctgtctgcaa gcgtggggga cagggtcacc atgacctgca gtgccagctc aagtgtaagt     1320

tacatgaact ggtaccagca gaagccgggc aaggccccca aaagatggat ttatgactca     1380

tccaaactgg cttctggagt ccctgctcgc ttcagtggca gtgggtctgg gaccgactat     1440

accctcacaa tcagcagcct gcagcccgaa gatttcgcca cttattactg ccagcagtgg     1500

agtcgtaacc cacccacgtt cggagggggg accaagctac aaattacatc ctccagctaa     1560


<210>  2
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc DRA222 (TSC311 or TSC312) CD3-binding domain

<400>  2

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
305                 310                 315                 320 


Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp 
                325                 330                 335     


Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
385                 390                 395                 400 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser 
                405                 410                 415     


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            420                 425                 430         


Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
    450                 455                 460                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp 
465                 470                 475                 480 


Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
                485                 490                 495     


Ser Ser Ser 
            


<210>  3
<211>  1569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H7L1 (TSC313) CD3-binding domain

<400>  3
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtctcct gcaaggcttc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagggtc     1020

accatgacca gggacacgtc catcagcaca gcctacatgg agctgagcag gctgagatct     1080

gacgacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcccccaa aagatggatt     1380

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     1440

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     1500

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacatcc     1560

tccagctaa                                                             1569


<210>  4
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H7L1 (TSC313) CD3-binding domain

<400>  4

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                485                 490                 495     


Gln Ile Thr Ser Ser Ser 
            500         


<210>  5
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H7L4 (TSC314) CD3-binding domain

<400>  5
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtctcct gcaaggcttc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagggtc     1020

accatgacca gggacacgtc catcagcaca gcctacatgg agctgagcag gctgagatct     1080

gacgacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg aaattgtgtt gacacagtct     1260

ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccaacag aaacctggcc aggctcccag gctcctcatc     1380

tatgactcat ccaaactggc ttctggcatc ccagccaggt tcagtggcag tgggtctggg     1440

acagacttca ctctcaccat cagcagccta gagcctgaag attttgcagt ttattactgt     1500

cagcagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  6
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H7L4 (TSC314) CD3-binding domain

<400>  6

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  7
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H7L5 (TSC315) CD3-binding domain

<400>  7
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtctcct gcaaggcttc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagggtc     1020

accatgacca gggacacgtc catcagcaca gcctacatgg agctgagcag gctgagatct     1080

gacgacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gctcctgatc     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagtggcag tggatctggg     1440

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  8
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H7L5 (TSC315) CD3-binding domain

<400>  8

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  9
<211>  1569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H8L1 (TSC316) CD3-binding domain

<400>  9
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtttcct gcaaggcatc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

accatgacca gggacacgtc cacgagcaca gtctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgctaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcccccaa aagatggatt     1380

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     1440

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     1500

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacatcc     1560

tccagctaa                                                             1569


<210>  10
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H8L1 (TSC316) CD3-binding domain

<400>  10

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                485                 490                 495     


Gln Ile Thr Ser Ser Ser 
            500         


<210>  11
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H8L4 (TSC317) CD3-binding domain

<400>  11
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtttcct gcaaggcatc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

accatgacca gggacacgtc cacgagcaca gtctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgctaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg aaattgtgtt gacacagtct     1260

ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccaacag aaacctggcc aggctcccag gctcctcatc     1380

tatgactcat ccaaactggc ttctggcatc ccagccaggt tcagtggcag tgggtctggg     1440

acagacttca ctctcaccat cagcagccta gagcctgaag attttgcagt ttattactgt     1500

cagcagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  12
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H8L4 (TSC317) CD3-binding domain

<400>  12

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  13
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H8L5 (TSC318) CD3-binding domain

<400>  13
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtttcct gcaaggcatc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

accatgacca gggacacgtc cacgagcaca gtctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgctaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gctcctgatc     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagtggcag tggatctggg     1440

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  14
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H8L5 (TSC318) CD3-binding domain

<400>  14

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  15
<211>  1569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H9L1 (TSC319) CD3-binding domain

<400>  15
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagcttgt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtttcct gcaaggcttc tggctacacc      900

tttactagat ctacgatgca ttgggtgcgc caggcccccg gacaaaggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagggtc     1020

accattacca gggacacatc cgcgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaagacacgg ctgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcccccaa aagatggatt     1380

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     1440

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     1500

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacatcc     1560

tccagctaa                                                             1569


<210>  16
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H9L1 (TSC319) CD3-binding domain

<400>  16

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                485                 490                 495     


Gln Ile Thr Ser Ser Ser 
            500         


<210>  17
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H9L4 (TSC320) CD3-binding domain

<400>  17
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagcttgt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtttcct gcaaggcttc tggctacacc      900

tttactagat ctacgatgca ttgggtgcgc caggcccccg gacaaaggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagggtc     1020

accattacca gggacacatc cgcgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaagacacgg ctgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg aaattgtgtt gacacagtct     1260

ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccaacag aaacctggcc aggctcccag gctcctcatc     1380

tatgactcat ccaaactggc ttctggcatc ccagccaggt tcagtggcag tgggtctggg     1440

acagacttca ctctcaccat cagcagccta gagcctgaag attttgcagt ttattactgt     1500

cagcagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  18
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H9L4 (TSC320) CD3-binding domain

<400>  18

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  19
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H9L5 (TSC321) CD3-binding domain

<400>  19
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagcttgt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtttcct gcaaggcttc tggctacacc      900

tttactagat ctacgatgca ttgggtgcgc caggcccccg gacaaaggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagggtc     1020

accattacca gggacacatc cgcgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaagacacgg ctgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gctcctgatc     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagtggcag tggatctggg     1440

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  20
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H9L5 (TSC321) CD3-binding domain

<400>  20

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  21
<211>  1569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H10L1 (TSC322) CD3-binding domain

<400>  21
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggaggcacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcccccaa aagatggatt     1380

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     1440

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     1500

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacatcc     1560

tccagctaa                                                             1569


<210>  22
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H10L1 (TSC322) CD3-binding domain

<400>  22

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                485                 490                 495     


Gln Ile Thr Ser Ser Ser 
            500         


<210>  23
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H10L4 (TSC323) CD3-binding domain

<400>  23
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggaggcacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg aaattgtgtt gacacagtct     1260

ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccaacag aaacctggcc aggctcccag gctcctcatc     1380

tatgactcat ccaaactggc ttctggcatc ccagccaggt tcagtggcag tgggtctggg     1440

acagacttca ctctcaccat cagcagccta gagcctgaag attttgcagt ttattactgt     1500

cagcagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  24
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H10L4 (TSC323) CD3-binding domain

<400>  24

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  25
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H10L5 (TSC324) CD3-binding domain

<400>  25
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcgtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggaggcacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gctcctgatc     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagtggcag tggatctggg     1440

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  26
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H10L5 (TSC324) CD3-binding domain

<400>  26

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  27
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H7L6 (TSC334) CD3-binding domain

<400>  27
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtctcct gcaaggcttc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagggtc     1020

accatgacca gggacacgtc catcagcaca gcctacatgg agctgagcag gctgagatct     1080

gacgacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagtggcag tggatctggg     1440

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  28
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H7L6 (TSC334) CD3-binding domain

<400>  28

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  29
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H7L7 (TSC335) CD3-binding domain

<400>  29
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtctcct gcaaggcttc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagggtc     1020

accatgacca gggacacgtc catcagcaca gcctacatgg agctgagcag gctgagatct     1080

gacgacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg aaattgtgtt gacgcagtct     1260

ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccagcag aaacctggcc tggcgcccag gagatggatt     1380

tatgactcat ccaaactggc ttctggcatc ccagacaggt tcagtggcag tgggtctggg     1440

acagacttca ctctcaccat cagcagactg gagcctgaag attttgcagt gtattactgt     1500

cagcagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  30
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H7L7 (TSC335) CD3-binding domain

<400>  30

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Leu Ala Pro Arg Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  31
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H7L8 (TSC336) CD3-binding domain

<400>  31
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtctcct gcaaggcttc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagggtc     1020

accatgacca gggacacgtc catcagcaca gcctacatgg agctgagcag gctgagatct     1080

gacgacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagaattca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  32
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H7L8 (TSC336) CD3-binding domain

<400>  32

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  33
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H8L6 (TSC337) CD3-binding domain

<400>  33
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtttcct gcaaggcatc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

accatgacca gggacacgtc cacgagcaca gtctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgctaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagtggcag tggatctggg     1440

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  34
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H8L6 (TSC337) CD3-binding domain

<400>  34

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  35
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H8L7 (TSC338) CD3-binding domain

<400>  35
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtttcct gcaaggcatc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

accatgacca gggacacgtc cacgagcaca gtctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgctaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg aaattgtgtt gacgcagtct     1260

ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccagcag aaacctggcc tggcgcccag gagatggatt     1380

tatgactcat ccaaactggc ttctggcatc ccagacaggt tcagtggcag tgggtctggg     1440

acagacttca ctctcaccat cagcagactg gagcctgaag attttgcagt gtattactgt     1500

cagcagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  36
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H8L7 (TSC338) CD3-binding domain

<400>  36

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Leu Ala Pro Arg Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  37
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H8L8 (TSC339) CD3-binding domain

<400>  37
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tgcagctggt gcagtctggg      840

gctgaggtga agaagcctgg ggcctcagtg aaggtttcct gcaaggcatc tggatacacc      900

ttcaccagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

accatgacca gggacacgtc cacgagcaca gtctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgctaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagaattca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  38
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H8L8 (TSC339) CD3-binding domain

<400>  38

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  39
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H10L6 (TSC340) CD3-binding domain

<400>  39
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggaggcacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagtggcag tggatctggg     1440

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  40
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H10L6 (TSC340) CD3-binding domain

<400>  40

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  41
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H10L7 (TSC341) CD3-binding domain

<400>  41
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggaggcacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg aaattgtgtt gacgcagtct     1260

ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag tgccagctca     1320

agtgtaagtt acatgaactg gtaccagcag aaacctggcc tggcgcccag gagatggatt     1380

tatgactcat ccaaactggc ttctggcatc ccagacaggt tcagtggcag tgggtctggg     1440

acagacttca ctctcaccat cagcagactg gagcctgaag attttgcagt gtattactgt     1500

cagcagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  42
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H10L7 (TSC341) CD3-binding domain

<400>  42

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Leu Ala Pro Arg Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  43
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc H10L8 (TSC342) CD3-binding domain

<400>  43
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggaggcacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagaattca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  44
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc H10L8 (TSC342) CD3-binding domain

<400>  44

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  45
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC370 CD3-binding domain

<400>  45
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggatatacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagaattca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  46
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC370 CD3-binding domain

<400>  46

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  47
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC371 CD3-binding domain

<400>  47
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggaggcacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggata      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagaattca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  48
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC371 CD3-binding domain

<400>  48

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  49
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC372 CD3-binding domain

<400>  49
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggaggcacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tgacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagaattca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  50
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC372 CD3-binding domain

<400>  50

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  51
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC390 CD3-binding domain

<400>  51
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

cctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggatatacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagagttca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  52
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC390 CD3-binding domain

<400>  52

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  53
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC391 CD3-binding domain

<400>  53
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

cctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggatatacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggata      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagagttca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  54
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC391 CD3-binding domain

<400>  54

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  55
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC392 CD3-binding domain

<400>  55
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

cctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggatatacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggatg      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tgacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagagttca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  56
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC392 CD3-binding domain

<400>  56

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  57
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC393 CD3-binding domain

<400>  57
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggatatacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggata      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tgacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagagttca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  58
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC393 CD3-binding domain

<400>  58

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  59
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC394 CD3-binding domain

<400>  59
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg      120

ggtgcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggcat acgcatgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatccaagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc cctgtctccg ggtcagaggc acaacaattc ttccctgaat      780

acaggaactc agatggcagg tcattctccg aattctcagg tccagctggt gcaatctggg      840

cctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcttc tggatatacc      900

ttcagcagat ctacgatgca ctgggtgcga caggcccctg gacaagggct tgagtggata      960

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacagagtc     1020

acgattaccg cggacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct     1080

gaggacacgg ccgtgtatta ctgtgcgaga ccccaagtcc actatgatta caacgggttt     1140

ccttactggg gccaaggaac cctggtcacc gtctcctcag gtggaggcgg ttcaggcgga     1200

ggtggatccg gcggtggcgg atcgggtggc ggcggatctg acatccagat gacccagtct     1260

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tgacttgcag tgccagctca     1320

agtgtaagtt acatgaactg gtatcagcag aaaccaggga aagcccctaa gagatggatt     1380

tatgactcat ccaaactggc ttctggggtc ccatcaaggt tcagcggcag tggatctggg     1440

acagagttca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc     1500

caacagtgga gtcgtaaccc acccactttc ggcggaggga ccaaggtgga gatcaaacgg     1560

tcctccagct aa                                                         1572


<210>  60
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC394 CD3-binding domain

<400>  60

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn 
225                 230                 235                 240 


Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu 
                245                 250                 255     


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
    290                 295                 300                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
305                 310                 315                 320 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                325                 330                 335     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            340                 345                 350         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                405                 410                 415     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    450                 455                 460                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys Arg Ser Ser Ser 
            500             


<210>  61
<211>  2301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC408 Anti-PSMA X anti-CD3 bispecific molecule

<400>  61
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

caatctgggc ctgaggtgaa gaagcctggg tcctcggtga aggtctcctg caaggcttct     1620

ggatatacct tcagcagatc tacgatgcac tgggtgcgac aggcccctgg acaagggctt     1680

gagtggatag gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacagagtca cgattaccgc ggacaaatcc acgagcacag cctacatgga gctgagcagc     1800

ctgagatctg aggacacggc cgtgtattac tgtgcgagac cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaaggaacc ctggtcaccg tctcctcagg tggaggcggt     1920

tcaggcggag gtggatccgg cggtggcgga tcgggtggcg gcggatctga catccagatg     1980

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat cacttgcagt     2040

gccagctcaa gtgtaagtta catgaactgg tatcagcaga aaccagggaa agcccctaag     2100

agatggattt atgactcatc caaactggct tctggggtcc catcaaggtt cagcggcagt     2160

ggatctggga cagagttcac tctcaccatc agcagcctgc agcctgatga ttttgcaact     2220

tattactgcc aacagtggag tcgtaaccca cccactttcg gcggagggac caaggtggag     2280

atcaaacggt cctccagcta a                                               2301


<210>  62
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC408 Anti-PSMA X anti-CD3 bispecific molecule

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser 
            500                 505                 510         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                565                 570                 575     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                645                 650                 655     


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
        675                 680                 685             


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    690                 695                 700                 


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
705                 710                 715                 720 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly 
                725                 730                 735     


Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745     


<210>  63
<211>  2301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC409 Anti-PSMA X anti-CD3 bispecific molecule

<400>  63
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

caatctgggc ctgaggtgaa gaagcctggg tcctcggtga aggtctcctg caaggcttct     1620

ggatatacct tcagcagatc tacgatgcac tgggtgcgac aggcccctgg acaagggctt     1680

gagtggatgg gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacagagtca cgattaccgc ggacaaatcc acgagcacag cctacatgga gctgagcagc     1800

ctgagatctg aggacacggc cgtgtattac tgtgcgagac cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaaggaacc ctggtcaccg tctcctcagg tggaggcggt     1920

tcaggcggag gtggatccgg cggtggcgga tcgggtggcg gcggatctga catccagatg     1980

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat gacttgcagt     2040

gccagctcaa gtgtaagtta catgaactgg tatcagcaga aaccagggaa agcccctaag     2100

agatggattt atgactcatc caaactggct tctggggtcc catcaaggtt cagcggcagt     2160

ggatctggga cagagttcac tctcaccatc agcagcctgc agcctgatga ttttgcaact     2220

tattactgcc aacagtggag tcgtaaccca cccactttcg gcggagggac caaggtggag     2280

atcaaacggt cctccagcta a                                               2301


<210>  64
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC409 Anti-PSMA X anti-CD3 bispecific molecule

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser 
            500                 505                 510         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                565                 570                 575     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                645                 650                 655     


Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
        675                 680                 685             


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    690                 695                 700                 


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
705                 710                 715                 720 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly 
                725                 730                 735     


Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745     


<210>  65
<211>  2301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC410 Anti-PSMA X anti-CD3 bispecific molecule

<400>  65
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

caatctgggg ctgaggtgaa gaagcctggg tcctcggtga aggtctcctg caaggcttct     1620

ggatatacct tcagcagatc tacgatgcac tgggtgcgac aggcccctgg acaagggctt     1680

gagtggatag gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacagagtca cgattaccgc ggacaaatcc acgagcacag cctacatgga gctgagcagc     1800

ctgagatctg aggacacggc cgtgtattac tgtgcgagac cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaaggaacc ctggtcaccg tctcctcagg tggaggcggt     1920

tcaggcggag gtggatccgg cggtggcgga tcgggtggcg gcggatctga catccagatg     1980

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat gacttgcagt     2040

gccagctcaa gtgtaagtta catgaactgg tatcagcaga aaccagggaa agcccctaag     2100

agatggattt atgactcatc caaactggct tctggggtcc catcaaggtt cagcggcagt     2160

ggatctggga cagagttcac tctcaccatc agcagcctgc agcctgatga ttttgcaact     2220

tattactgcc aacagtggag tcgtaaccca cccactttcg gcggagggac caaggtggag     2280

atcaaacggt cctccagcta a                                               2301


<210>  66
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC410 Anti-PSMA X anti-CD3 bispecific molecule

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 
            500                 505                 510         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                565                 570                 575     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                645                 650                 655     


Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
        675                 680                 685             


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    690                 695                 700                 


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
705                 710                 715                 720 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly 
                725                 730                 735     


Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745     


<210>  67
<211>  2301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC411 Anti-PSMA X anti-CD3 bispecific molecule

<400>  67
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

caatctgggc ctgaggtgaa gaagcctggg tcctcggtga aggtctcctg caaggcttct     1620

ggatatacct tcagcagatc tacgatgcac tgggtgcgac aggcccctgg acaagggctt     1680

gagtggatag gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacagagtca cgattaccgc ggacaaatcc acgagcacag cctacatgga gctgagcagc     1800

ctgagatctg aggacacggc cgtgtattac tgtgcgagac cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaaggaacc ctggtcaccg tctcctcagg tggaggcggt     1920

tcaggcggag gtggatccgg cggtggcgga tcgggtggcg gcggatctga catccagatg     1980

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat gacttgcagt     2040

gccagctcaa gtgtaagtta catgaactgg tatcagcaga aaccagggaa agcccctaag     2100

agatggattt atgactcatc caaactggct tctggggtcc catcaaggtt cagcggcagt     2160

ggatctggga cagagttcac tctcaccatc agcagcctgc agcctgatga ttttgcaact     2220

tattactgcc aacagtggag tcgtaaccca cccactttcg gcggagggac caaggtggag     2280

atcaaacggt cctccagcta a                                               2301


<210>  68
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC411 Anti-PSMA X anti-CD3 bispecific molecule

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser 
            500                 505                 510         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                565                 570                 575     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
625                 630                 635                 640 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                645                 650                 655     


Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
        675                 680                 685             


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    690                 695                 700                 


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
705                 710                 715                 720 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly 
                725                 730                 735     


Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745     


<210>  69
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAS105 Anti-CD37 X anti-CD3 bispecific molecule

<400>  69
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtcaga ggcacaacaa ttcttccctg aatacaggaa ctcagatggc aggtcattct     1560

ccgaattctc aggtccagct ggtggagtct gggggcggag tggtgcagcc tgggcggtca     1620

ctgaggctgt cctgcaaggc ttctggctac acctttacta gatctacgat gcactgggta     1680

aggcaggccc ctggacaagg tctggaatgg attggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacagg ttcacaatca gcgcagacaa atccaagagc     1800

acagccttcc tgcagatgga cagcctgagg cccgaggaca ccggcgtcta tttctgtgca     1860

cggccccaag tccactatga ttacaacggg tttccttact ggggccaagg gactcccgtc     1920

actgtctcta gcggtggcgg agggtctggg ggtggcggat ccggaggtgg tggctctgca     1980

caagacatcc agatgaccca gtctccaagc agcctgtctg caagcgtggg ggacagggtc     2040

accatgacct gcagtgccag ctcaagtgta agttacatga actggtacca gcagaagccg     2100

ggcaaggccc ccaaaagatg gatttatgac tcatccaaac tggcttctgg agtccctgct     2160

cgcttcagtg gcagtgggtc tgggaccgac tataccctca caatcagcag cctgcagccc     2220

gaagatttcg ccacttatta ctgccagcag tggagtcgta acccacccac gttcggaggg     2280

gggaccaagc tacaaattac atcctccagc taa                                  2313


<210>  70
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAS105 Anti-CD37 X anti-CD3 bispecific molecule

<400>  70

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
                485                 490                 495     


Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
            500                 505                 510         


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp 
                565                 570                 575     


Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
            580                 585                 590         


Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
625                 630                 635                 640 


Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745                 750 


<210>  71
<211>  2325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC445 anti-CD3 bispecific molecule

<400>  71
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtcaga ggcacaacaa ttcttccctg aatacaggaa ctcagatggc aggtcattct     1560

ccgaattctc aggtccagct ggtgcaatct gggcctgagg tgaagaagcc tgggtcctcg     1620

gtgaaggtct cctgcaaggc ttctggatat accttcagca gatctacgat gcactgggtg     1680

cgacaggccc ctggacaagg gcttgagtgg ataggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacaga gtcacgatta ccgcggacaa atccacgagc     1800

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgcg     1860

agaccccaag tccactatga ttacaacggg tttccttact ggggccaagg aaccctggtc     1920

accgtctcct caggtggagg cggttcaggc ggaggtggat ccggcggtgg cggatcgggt     1980

ggcggcggat ctgacatcca gatgacccag tctccttcca ccctgtctgc atctgtagga     2040

gacagagtca ccatgacttg cagtgccagc tcaagtgtaa gttacatgaa ctggtatcag     2100

cagaaaccag ggaaagcccc taagagatgg atttatgact catccaaact ggcttctggg     2160

gtcccatcaa ggttcagcgg cagtggatct gggacagagt tcactctcac catcagcagc     2220

ctgcagcctg atgattttgc aacttattac tgccaacagt ggagtcgtaa cccacccact     2280

ttcggcggag ggaccaaggt ggagatcaaa cggtcctcca gctaa                     2325


<210>  72
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC445 anti-CD3 bispecific molecule

<400>  72

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
                485                 490                 495     


Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Pro 
            500                 505                 510         


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp 
                565                 570                 575     


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
            580                 585                 590         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
                645                 650                 655     


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
            660                 665                 670         


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        675                 680                 685             


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 
    690                 695                 700                 


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
705                 710                 715                 720 


Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
                725                 730                 735     


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745                 750         


Ser Ser 
        


<210>  73
<211>  2325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC452 anti-CD3 bispecific molecule

<400>  73
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtcaga ggcacaacaa ttcttccctg aatacaggaa ctcagatggc aggtcattct     1560

ccgaattctc aggtccagct ggtggagtct gggggcggag tggtgcagcc tgggcggtca     1620

ctgaggctgt cctgcaaggc ttctggctac acctttacta gatctacgat gcactgggta     1680

aggcaggccc ctggacaagg tctggaatgg attggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacagg ttcacaatca gcgcagacaa atccaagagc     1800

acagccttcc tgcagatgga cagcctgagg cccgaggaca ccggcgtcta tttctgtgca     1860

cggccccaag tccactatga ttacaacggg tttccttact ggggccaagg gactcccgtc     1920

actgtctcta gcggtggcgg agggtctggg ggtggcggat ccggcggtgg cggatcgggt     1980

ggcggcggat ctgacatcca gatgacccag tctccttcca ccctgtctgc atctgtagga     2040

gacagagtca ccatgacttg cagtgccagc tcaagtgtaa gttacatgaa ctggtatcag     2100

cagaaaccag ggaaagcccc taagagatgg atttatgact catccaaact ggcttctggg     2160

gtcccatcaa ggttcagcgg cagtggatct gggacagagt tcactctcac catcagcagc     2220

ctgcagcctg atgattttgc aacttattac tgccaacagt ggagtcgtaa cccacccact     2280

ttcggcggag ggaccaaggt ggagatcaaa cggtcctcca gctaa                     2325


<210>  74
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC452 anti-CD3 bispecific molecule

<400>  74

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
                485                 490                 495     


Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
            500                 505                 510         


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp 
                565                 570                 575     


Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
            580                 585                 590         


Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
                645                 650                 655     


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
            660                 665                 670         


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        675                 680                 685             


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 
    690                 695                 700                 


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
705                 710                 715                 720 


Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
                725                 730                 735     


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745                 750         


Ser Ser 
        


<210>  75
<211>  2322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC453 anti-CD3 bispecific molecule

<400>  75
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtcaga ggcacaacaa ttcttccctg aatacaggaa ctcagatggc aggtcattct     1560

ccgaattctc aggtccagct ggtgcaatct gggcctgagg tgaagaagcc tgggtcctcg     1620

gtgaaggtct cctgcaaggc ttctggatat accttcagca gatctacgat gcactgggtg     1680

cgacaggccc ctggacaagg gcttgagtgg ataggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacaga gtcacgatta ccgcggacaa atccacgagc     1800

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgcg     1860

agaccccaag tccactatga ttacaacggg tttccttact ggggccaagg aaccctggtc     1920

accgtctcct caggtggagg cggttcaggc ggaggtggat ccggaggtgg tggctctggt     1980

ggcggcggat ctgacatcca gatgacccag tctccaagca gcctgtctgc aagcgtgggg     2040

gacagggtca ccatgacctg cagtgccagc tcaagtgtaa gttacatgaa ctggtaccag     2100

cagaagccgg gcaaggcccc caaaagatgg atttatgact catccaaact ggcttctgga     2160

gtccctgctc gcttcagtgg cagtgggtct gggaccgact ataccctcac aatcagcagc     2220

ctgcagcccg aagatttcgc cacttattac tgccagcagt ggagtcgtaa cccacccacg     2280

ttcggagggg ggaccaagct acaaattaca tcctccagct aa                        2322


<210>  76
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC453 anti-CD3 bispecific molecule

<400>  76

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
                485                 490                 495     


Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Pro 
            500                 505                 510         


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp 
                565                 570                 575     


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
            580                 585                 590         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
                645                 650                 655     


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
            660                 665                 670         


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        675                 680                 685             


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg 
    690                 695                 700                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
705                 710                 715                 720 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
                725                 730                 735     


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser 
            740                 745                 750         


Ser 
    


<210>  77
<211>  2325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC454 anti-CD3 bispecific molecule

<400>  77
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtcaga ggcacaacaa ttcttccctg aatacaggaa ctcagatggc aggtcattct     1560

ccgaattctc aggtccagct ggtgcaatct gggcctgagg tgaagaagcc tgggtcctcg     1620

gtgaaggtct cctgcaaggc ttctggatat accttcagca gatctacgat gcactgggtg     1680

cgacaggccc ctggacaagg gcttgagtgg ataggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacaga gtcacgatta ccgcggacaa atccacgagc     1800

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgcg     1860

agaccccaag tccactatga ttacaacggg tttccttact ggggccaagg aaccctggtc     1920

accgtctcct caggtggagg cggttcaggc ggaggtggat ccggcggtgg cggatcgggt     1980

ggcggcggat ctgacatcca gatgacccag tctccttcca ccctgtctgc atctgtagga     2040

gacagagtca ccatgacttg cagtgccagc tcaagtgtaa gttacatgaa ctggtatcag     2100

cagaaaccag ggaaagcccc taagagatgg atttatgact catccaaact ggcttctggg     2160

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc     2220

ctgcagcctg atgattttgc aacttattac tgccaacagt ggagtcgtaa cccacccact     2280

ttcggcggag ggaccaaggt ggagatcaaa cggtcctcca gctaa                     2325


<210>  78
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC454 anti-CD3 bispecific molecule

<400>  78

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
                485                 490                 495     


Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Pro 
            500                 505                 510         


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp 
                565                 570                 575     


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
            580                 585                 590         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
                645                 650                 655     


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
            660                 665                 670         


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        675                 680                 685             


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 
    690                 695                 700                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
705                 710                 715                 720 


Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
                725                 730                 735     


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745                 750         


Ser Ser 
        


<210>  79
<211>  2325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC455 anti-CD3 bispecific molecule

<400>  79
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtcaga ggcacaacaa ttcttccctg aatacaggaa ctcagatggc aggtcattct     1560

ccgaattctc aggtccagct ggtgcaatct gggcctgagg tgaagaagcc tgggtcctcg     1620

gtgaaggtct cctgcaaggc ttctggatat accttcagca gatctacgat gcactgggtg     1680

cgacaggccc ctggacaagg gcttgagtgg ataggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacaga gtcacgatta ccgcggacaa atccacgagc     1800

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgcg     1860

agaccccaag tccactatga ttacaacggg tttccttact ggggccaagg aaccctggtc     1920

accgtctcct caggtggagg cggttcaggc ggaggtggat ccggcggtgg cggatcgggt     1980

ggcggcggat ctgacatcca gatgacccag tctccttcca ccctgtctgc atctgtagga     2040

gacagagtca ccatgacttg cagtgccagc tcaagtgtaa gttacatgaa ctggtatcag     2100

cagaaaccag ggaaagcccc taagagatgg atttatgact catccaaact ggcttctggg     2160

gtcccatcaa ggttcagcgg cagtggatct gggacagagt atactctcac catcagcagc     2220

ctgcagcctg atgattttgc aacttattac tgccaacagt ggagtcgtaa cccacccact     2280

ttcggcggag ggaccaaggt ggagatcaaa cggtcctcca gctaa                     2325


<210>  80
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC455 anti-CD3 bispecific molecule

<400>  80

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
                485                 490                 495     


Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Pro 
            500                 505                 510         


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp 
                565                 570                 575     


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
            580                 585                 590         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
                645                 650                 655     


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
            660                 665                 670         


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        675                 680                 685             


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 
    690                 695                 700                 


Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser 
705                 710                 715                 720 


Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
                725                 730                 735     


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745                 750         


Ser Ser 
        


<210>  81
<211>  2325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC456 anti-CD3 bispecific molecule

<400>  81
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatt      120

tcctgtaagg gctccggtta ctcattcact ggctacaata tgaactgggt gcgccagatg      180

cccgggaaag gcctggagtg gatgggcaat attgatcctt attatggtgg tactacctac      240

aaccggaagt tcaagggcca ggtcactatc tccgccgaca agtccatcag caccgcctac      300

ctgcaatgga gcagcctgaa ggcctcggac accgccatgt attactgtgc acgctcagtc      360

ggccctttcg actcctgggg ccagggcacc ctggtcactg tctcctctgg gggtggaggc      420

tctggtggcg gtggctctgg cggaggtgga tccggtggcg gcggatctgg cgggggtggc      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg cgaaagagcc      540

accctctcct gccgagcaag tgaaaatgtt tacagctact tagcctggta ccaacagaaa      600

cctggccagg ctcctaggct cctcatctat tttgcaaaaa ccttagcaga aggtattcca      660

gccaggttca gtggcagtgg ctccgggaca gacttcactc tcaccatcag cagcctagag      720

cctgaagatt ttgcagttta ttactgtcaa catcattccg ataatccgtg gacattcggc      780

caagggacca aggtggaaat caaatcctcg agtgagccca aatcttctga caaaactcac      840

acatgcccac cgtgcccagc acctgaagcc gcgggtgcac cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg catacgcgtg cgcggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat     1320

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1500

ccgggtcaga ggcacaacaa ttcttccctg aatacaggaa ctcagatggc aggtcattct     1560

ccgaattctc aggtccagct ggtgcaatct gggcctgagg tgaagaagcc tgggtcctcg     1620

gtgaaggtct cctgcaaggc ttctggatat accttcagca gatctacgat gcactgggtg     1680

cgacaggccc ctggacaagg gcttgagtgg ataggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacaga gtcacgatta ccgcggacaa atccacgagc     1800

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgcg     1860

agaccccaag tccactatga ttacaacggg tttccttact ggggccaagg aaccctggtc     1920

accgtctcct caggtggagg cggttcaggc ggaggtggat ccggcggtgg cggatcgggt     1980

ggcggcggat ctgacatcca gatgacccag tctccttcca ccctgtctgc atctgtagga     2040

gacagagtca ccatgacttg cagtgccagc tcaagtgtaa gttacatgaa ctggtatcag     2100

cagaaaccag ggaaagcccc taagagatgg atttatgact catccaaact ggcttctggg     2160

gtcccatcaa ggttcagcgg cagtggatct gggacagatt atactctcac catcagcagc     2220

ctgcagcctg atgattttgc aacttattac tgccaacagt ggagtcgtaa cccacccact     2280

ttcggcggag ggaccaaggt ggagatcaaa cggtcctcca gctaa                     2325


<210>  82
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD37 X TSC456 anti-CD3 bispecific molecule

<400>  82

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Pro Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Phe Ala 
            180                 185                 190         


Lys Thr Leu Ala Glu Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln His His Ser Asp Asn Pro Trp Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
            260                 265                 270         


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
                485                 490                 495     


Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly Pro 
            500                 505                 510         


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp 
                565                 570                 575     


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
            580                 585                 590         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
                645                 650                 655     


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
            660                 665                 670         


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        675                 680                 685             


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 
    690                 695                 700                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
705                 710                 715                 720 


Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
                725                 730                 735     


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745                 750         


Ser Ser 
        


<210>  83
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC455 CD3 scFv CD3-binding domain

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
                245                 250     


<210>  84
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC456 CD3 scFv CD3-binding domain

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
                245                 250     


<210>  85
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA222 CD3 scFv CD3-binding domain

<400>  85

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser 
                245         


<210>  86
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC455 and TSC456 variable heavy domain CD3-binding domain

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  87
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA222 variable heavy domain CD3-binding domain

<400>  87

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  88
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC455 variable light domain CD3-binding domain

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            100                 105             


<210>  89
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC456 variable light domain CD3-binding domain

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            100                 105             


<210>  90
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA222 variable light domain CD3-binding domain

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser 
            100                 105         


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VH CDR1 (Kabat) CD3-binding domain

<400>  91

Arg Ser Thr Met His 
1               5   


<210>  92
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VH CDR2 (Kabat) CD3-binding domain

<400>  92

Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VH CDR3 (Kabat) CD3-binding domain

<400>  93

Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10      


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VL CDR1 (Kabat) CD3-binding domain

<400>  94

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VL CDR2 (Kabat) CD3-binding domain

<400>  95

Asp Ser Ser Lys Leu Ala Ser 
1               5           


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VL CDR3 (Kabat) CD3-binding domain

<400>  96

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  97
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR133 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  97
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tctcctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacg gcgacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag ctaa                                            2304


<210>  98
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR133 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            500                 505                 510         


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
                565                 570                 575     


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
            580                 585                 590         


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile 
625                 630                 635                 640 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                645                 650                 655     


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            660                 665                 670         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser 
        675                 680                 685             


Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    690                 695                 700                 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
705                 710                 715                 720 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly 
                725                 730                 735     


Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745         


<210>  99
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR193 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  99
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tctcctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacg gcgacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtgcaatc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc     1620

tcctgcaagg cttctggata taccttcagc agatctacga tgcactgggt gcgacaggcc     1680

cctggacaag ggcttgagtg gataggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatccacgag cacagcctac     1800

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc     1920

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga     1980

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc     2040

accatgactt gcagtgccag ctcaagtgta agttacatga actggtatca gcagaaacca     2100

gggaaagccc ctaagagatg gatttatgac tcatccaaac tggcttctgg ggtcccatca     2160

aggttcagcg gcagtggatc tgggacagag tatactctca ccatcagcag cctgcagcct     2220

gatgattttg caacttatta ctgccaacag tggagtcgta acccacccac tttcggcgga     2280

gggaccaagg tggagatcaa acggtcctcc agctaa                               2316


<210>  100
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR193 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
            500                 505                 510         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
                565                 570                 575     


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            580                 585                 590         


Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745                 750     


<210>  101
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR134 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  101
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggcggctc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tctcctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc gactcggtga agggccggtt caccatctcc      660

cggcactcct ccaagaacac cctgtacctg cagatgaact ccctgcgggc cgaggacacc      720

gccgtgtact tctgcgcccg gggctactcc acctactacg gcgacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag ctaa                                            2304


<210>  102
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR134 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg His Ser Ser Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            500                 505                 510         


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
                565                 570                 575     


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
            580                 585                 590         


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile 
625                 630                 635                 640 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                645                 650                 655     


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            660                 665                 670         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser 
        675                 680                 685             


Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    690                 695                 700                 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
705                 710                 715                 720 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly 
                725                 730                 735     


Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745         


<210>  103
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR189 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  103
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggcggctc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tctcctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc gactcggtga agggccggtt caccatctcc      660

cggcactcct ccaagaacac cctgtacctg cagatgaact ccctgcgggc cgaggacacc      720

gccgtgtact tctgcgcccg gggctactcc acctactacg gcgacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtgcaatc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc     1620

tcctgcaagg cttctggata taccttcagc agatctacga tgcactgggt gcgacaggcc     1680

cctggacaag ggcttgagtg gataggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatccacgag cacagcctac     1800

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc     1920

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga     1980

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc     2040

accatgactt gcagtgccag ctcaagtgta agttacatga actggtatca gcagaaacca     2100

gggaaagccc ctaagagatg gatttatgac tcatccaaac tggcttctgg ggtcccatca     2160

aggttcagcg gcagtggatc tgggacagat tatactctca ccatcagcag cctgcagcct     2220

gatgattttg caacttatta ctgccaacag tggagtcgta acccacccac tttcggcgga     2280

gggaccaagg tggagatcaa acggtcctcc agctaa                               2316


<210>  104
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR189 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg His Ser Ser Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Gly Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
            500                 505                 510         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
                565                 570                 575     


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            580                 585                 590         


Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745                 750     


<210>  105
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR154 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  105
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag ctaa                                            2304


<210>  106
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR154 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            500                 505                 510         


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
                565                 570                 575     


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
            580                 585                 590         


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile 
625                 630                 635                 640 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                645                 650                 655     


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            660                 665                 670         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser 
        675                 680                 685             


Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    690                 695                 700                 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
705                 710                 715                 720 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly 
                725                 730                 735     


Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745         


<210>  107
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR185 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  107
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtgcaatc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc     1620

tcctgcaagg cttctggata taccttcagc agatctacga tgcactgggt gcgacaggcc     1680

cctggacaag ggcttgagtg gataggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatccacgag cacagcctac     1800

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc     1920

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga     1980

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc     2040

accatgactt gcagtgccag ctcaagtgta agttacatga actggtatca gcagaaacca     2100

gggaaagccc ctaagagatg gatttatgac tcatccaaac tggcttctgg ggtcccatca     2160

aggttcagcg gcagtggatc tgggacagat tatactctca ccatcagcag cctgcagcct     2220

gatgattttg caacttatta ctgccaacag tggagtcgta acccacccac tttcggcgga     2280

gggaccaagg tggagatcaa acggtcctcc agctaa                               2316


<210>  108
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR185 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
            500                 505                 510         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
                565                 570                 575     


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            580                 585                 590         


Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745                 750     


<210>  109
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR179 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  109
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ctggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag ctaa                                            2304


<210>  110
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR179 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Trp Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            500                 505                 510         


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
                565                 570                 575     


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
            580                 585                 590         


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile 
625                 630                 635                 640 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                645                 650                 655     


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            660                 665                 670         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser 
        675                 680                 685             


Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    690                 695                 700                 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
705                 710                 715                 720 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly 
                725                 730                 735     


Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745         


<210>  111
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR186 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  111
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ctggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtgcaatc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc     1620

tcctgcaagg cttctggata taccttcagc agatctacga tgcactgggt gcgacaggcc     1680

cctggacaag ggcttgagtg gataggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatccacgag cacagcctac     1800

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc     1920

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga     1980

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc     2040

accatgactt gcagtgccag ctcaagtgta agttacatga actggtatca gcagaaacca     2100

gggaaagccc ctaagagatg gatttatgac tcatccaaac tggcttctgg ggtcccatca     2160

aggttcagcg gcagtggatc tgggacagat tatactctca ccatcagcag cctgcagcct     2220

gatgattttg caacttatta ctgccaacag tggagtcgta acccacccac tttcggcgga     2280

gggaccaagg tggagatcaa acggtcctcc agctaa                               2316


<210>  112
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR186 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Trp Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
            500                 505                 510         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
                565                 570                 575     


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            580                 585                 590         


Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745                 750     


<210>  113
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR181 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  113
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggcggctc cctgcggctg tcctgcaccg tgtccggcac cgacatcaac      540

gactacccca tctcctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc gactcggtga agggccggtt caccatctcc      660

cggcactcct ccaagaacac cctgtacctg cagatgaact ccctgcgggc cgaggacacc      720

gccgtgtact tctgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag ctaa                                            2304


<210>  114
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR181 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Thr Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg His Ser Ser Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            500                 505                 510         


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
                565                 570                 575     


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
            580                 585                 590         


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile 
625                 630                 635                 640 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                645                 650                 655     


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            660                 665                 670         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser 
        675                 680                 685             


Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    690                 695                 700                 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
705                 710                 715                 720 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly 
                725                 730                 735     


Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745         


<210>  115
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR191 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  115
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggcggctc cctgcggctg tcctgcaccg tgtccggcac cgacatcaac      540

gactacccca tctcctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc gactcggtga agggccggtt caccatctcc      660

cggcactcct ccaagaacac cctgtacctg cagatgaact ccctgcgggc cgaggacacc      720

gccgtgtact tctgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtgcaatc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc     1620

tcctgcaagg cttctggata taccttcagc agatctacga tgcactgggt gcgacaggcc     1680

cctggacaag ggcttgagtg gataggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatccacgag cacagcctac     1800

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc     1920

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga     1980

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc     2040

accatgactt gcagtgccag ctcaagtgta agttacatga actggtatca gcagaaacca     2100

gggaaagccc ctaagagatg gatttatgac tcatccaaac tggcttctgg ggtcccatca     2160

aggttcagcg gcagtggatc tgggacagat tatactctca ccatcagcag cctgcagcct     2220

gatgattttg caacttatta ctgccaacag tggagtcgta acccacccac tttcggcgga     2280

gggaccaagg tggagatcaa acggtcctcc agctaa                               2316


<210>  116
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR191 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  116

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Thr Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg His Ser Ser Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
            500                 505                 510         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
                565                 570                 575     


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            580                 585                 590         


Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745                 750     


<210>  117
<211>  2304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR182 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  117
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggccagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgcccgac      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctggaggcc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggccagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag ctaa                                            2304


<210>  118
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR182 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  118

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            500                 505                 510         


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys 
                565                 570                 575     


Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
            580                 585                 590         


Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile 
625                 630                 635                 640 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                645                 650                 655     


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
            660                 665                 670         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser 
        675                 680                 685             


Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    690                 695                 700                 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
705                 710                 715                 720 


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly 
                725                 730                 735     


Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745         


<210>  119
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR192 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  119
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggccagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgcccgac      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctggaggcc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggccagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtgcaatc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc     1620

tcctgcaagg cttctggata taccttcagc agatctacga tgcactgggt gcgacaggcc     1680

cctggacaag ggcttgagtg gataggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatccacgag cacagcctac     1800

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc     1920

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga     1980

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc     2040

accatgactt gcagtgccag ctcaagtgta agttacatga actggtatca gcagaaacca     2100

gggaaagccc ctaagagatg gatttatgac tcatccaaac tggcttctgg ggtcccatca     2160

aggttcagcg gcagtggatc tgggacagat tatactctca ccatcagcag cctgcagcct     2220

gatgattttg caacttatta ctgccaacag tggagtcgta acccacccac tttcggcgga     2280

gggaccaagg tggagatcaa acggtcctcc agctaa                               2316


<210>  120
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR192 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  120

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
            500                 505                 510         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
                565                 570                 575     


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            580                 585                 590         


Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745                 750     


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sss(s)-hIgG1 hinge

<400>  121

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  122
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  csc(s)-hIgG1 hinge

<400>  122

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  123
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ssc(s)-hIgG1 hinge

<400>  123

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scc(s)-hIgG1 hinge

<400>  124

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  125
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  css(s)-hIgG1 hinge

<400>  125

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scs(s)-hIgG1 hinge

<400>  126

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ccc(s)-hIgG1 hinge

<400>  127

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  128
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ccc(p)-hIgG1 hinge

<400>  128

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  129
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sss(p)-hIgG1 hinge

<400>  129

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  130
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  csc(p)-hIgG1 hinge

<400>  130

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  131
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ssc(p)-hIgG1 hinge

<400>  131

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  132
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scc(p)-hIgG1 hinge

<400>  132

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  css(p)-hIgG1 hinge

<400>  133

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  134
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scs(p)-hIgG1 hinge

<400>  134

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  135
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Scppcp linker

<400>  135

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  136
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STD1 linker

<400>  136

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  137
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STD2 linker

<400>  137

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser 
        35              


<210>  138
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1 linker

<400>  138

Asn Ser 
1       


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 linker

<400>  139

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  140
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 linker

<400>  140

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  141
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4 linker

<400>  141

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  142
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H5 linker

<400>  142

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  143
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H6 linker

<400>  143

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  144
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H7 linker

<400>  144

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3 linker

<400>  145

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  146
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H105 linker

<400>  146

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  147
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)4 linker

<400>  147

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  148
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75 (NKG2A quadruple mutant) linker

<400>  148

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  149
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H83 (NKG2A derived) linker

<400>  149

Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  150
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H106 (NKG2A derived) linker

<400>  150

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser 
        


<210>  151
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H81 (NKG2D derived) linker

<400>  151

Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  


<210>  152
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H91 (NKG2D derived) linker

<400>  152

Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  153
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H94 linker

<400>  153

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  154
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H16 hinge

<400>  154

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  155
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H17 hinge

<400>  155

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  156
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H18 hinge

<400>  156

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  157
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H19 hinge

<400>  157

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H20 hinge

<400>  158

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Asn Ser 
1               5                   10                  15  


<210>  159
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H21 hinge

<400>  159

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  160
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H22 hinge

<400>  160

Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 
1               5                   10                  15  


<210>  161
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H23 hinge

<400>  161

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  162
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H24 hinge

<400>  162

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asn Ser 
1               5                   10                  15  


<210>  163
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H25 hinge

<400>  163

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  164
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H26 hinge

<400>  164

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  165
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H27 hinge

<400>  165

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  166
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H28 hinge

<400>  166

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser 
1               5                   10                  15  


<210>  167
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H30 hinge

<400>  167

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Asn Ser 
1               5                   10                  15  


<210>  168
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H32 hinge

<400>  168

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10                  15  


<210>  169
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H33 hinge

<400>  169

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  170
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H36 hinge

<400>  170

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  171
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H40 hinge

<400>  171

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H41 hinge

<400>  172

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  173
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H42 hinge

<400>  173

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  174
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H44 hinge

<400>  174

Gly Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  175
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H45 hinge

<400>  175

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  176
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H46 hinge

<400>  176

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 
1               5                   10          


<210>  177
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H47 hinge

<400>  177

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  178
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H48 hinge

<400>  178

Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10      


<210>  179
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H50 hinge

<400>  179

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  180
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H51 hinge

<400>  180

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  181
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H52 hinge

<400>  181

Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ser 
1               5                   10      


<210>  182
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H53 hinge

<400>  182

Ser Gln Pro Glu Ile Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10                  15      


<210>  183
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H54 hinge

<400>  183

Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  184
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H55 hinge

<400>  184

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  185
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H56 hinge

<400>  185

Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10          


<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H57 hinge

<400>  186

Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10  


<210>  187
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H58 hinge

<400>  187

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  188
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H59 hinge

<400>  188

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  189
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H60 hinge

<400>  189

Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Asn Ser 
1               5                   10                  15  


<210>  190
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H61 hinge

<400>  190

Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
1               5                   10                  15      


Asp Cys Pro Asn Ser 
            20      


<210>  191
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H62 hinge

<400>  191

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Cys Pro Asn Ser 
            20      


<210>  192
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H63 hinge

<400>  192

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  193
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ((Gly4Ser)3) linker

<400>  193

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  194
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)n linker


<220>
<221>  MISC_FEATURE
<222>  (6)..(25)
<223>  amino acid residues may be absent

<400>  194

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  195
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  secretory signal sequence

<400>  195

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  196
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H111 linker

<400>  196

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Gly Ser 
            


<210>  197
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric bispecific anti-CD123 (VLVH) x anti-CD3 (TSC456) 
       scFv-Fc-scFv CD3-binding domain

<400>  197

Asp Ile Met Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Phe Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Phe Phe Gly 
            20                  25                  30          


Ser Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala 
65                  70                  75                  80  


Ile Ser Ser Val Met Pro Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Asp Tyr Ser 
145                 150                 155                 160 


Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn 
                165                 170                 175     


Lys Leu Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr 
            180                 185                 190         


Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
        195                 200                 205             


Asn Gln Phe Phe Leu Lys Leu Ser Ser Val Thr Thr Glu Asp Thr Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Ser Arg Gly Glu Gly Phe Tyr Phe Asp Ser Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Thr Leu Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
            500                 505                 510         


Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        515                 520                 525             


Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    530                 535                 540                 


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr 
545                 550                 555                 560 


Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr 
                565                 570                 575     


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            580                 585                 590         


Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe 
        595                 600                 605             


Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ser 
            740                 745                 750     


<210>  198
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric bispecific anti-CD123 (VHVL) x anti-CD3 (TSC456) 
       scFv-Fc-scFv CD3-binding domain

<400>  198

Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser 
1               5                   10                  15      


Leu Ser Leu Thr Cys Ser Val Thr Asp Tyr Ser Ile Thr Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ser 
                85                  90                  95      


Arg Gly Glu Gly Phe Tyr Phe Asp Ser Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Met Met Ser Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ala Val Ser Val Gly Glu Lys Phe Thr Met Thr Cys Lys 
145                 150                 155                 160 


Ser Ser Gln Ser Leu Phe Phe Gly Ser Thr Gln Lys Asn Tyr Leu Ala 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp 
            180                 185                 190         


Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Ser Val Met Pro Glu Asp 
    210                 215                 220                 


Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu 
            500                 505                 510         


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        515                 520                 525             


Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly 
    530                 535                 540                 


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr 
545                 550                 555                 560 


Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys 
                565                 570                 575     


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            580                 585                 590         


Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn 
        595                 600                 605             


Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 
                645                 650                 655     


Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
            660                 665                 670         


Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg 
        675                 680                 685             


Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    690                 695                 700                 


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
705                 710                 715                 720 


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn 
                725                 730                 735     


Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser 
            740                 745                 750         


Ser 
    


<210>  199
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VH CDR1 (IMGT) CD3-binding domain

<400>  199

Gly Tyr Thr Phe Thr Arg Ser Thr 
1               5               


<210>  200
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VH CDR2 (IMGT) CD3-binding domain

<400>  200

Ile Asn Pro Ser Ser Ala Tyr Thr 
1               5               


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VH CDR3 (IMGT) CD3-binding domain

<400>  201

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VL CDR1 (IMGT) CD3-binding domain

<400>  202

Ala Ser Ser Ser Val Ser Tyr 
1               5           


<210>  203
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VL CDR2 (IMGT) CD3-binding domain

<400>  203

Asp Ser Ser 
1           


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cris7 and DRA222 VL CDR3 (IMGT) CD3-binding domain

<400>  204

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  205
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC471 Anti-PSMA X anti-CD3 bispecific molecule

<400>  205
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggaata caagtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttccggagg tggcggttcg     1500

ggaggtggcg ggtcaggagg tgggggctct ccttcacagg tgcagctggt gcagtctggt     1560

cctgaggtga aaaagcctgg ctccagcgtg aaggtgtcct gcaaggccag cggatacacc     1620

tttagccggt ccaccatgca ttgggtgagg caggctcctg gacagggcct ggagtggatc     1680

ggctacatca accccagcag cgcttatacc aactacaatc agaagtttaa ggaccgggtg     1740

accatcaccg ccgataagtc caccagcacc gcctacatgg agctgtccag cctgaggagc     1800

gaggataccg ccgtgtacta ttgcgcccgg ccccaggtcc attacgacta caacggcttc     1860

ccctattggg gccagggaac cctggtgacc gtgtccagcg gtggcggtgg cagcggcggc     1920

ggcggctctg gcggaggtgg cagcggcgga gggggctccg acattcagat gacccagtcc     1980

ccctccaccc tgtccgctag cgtgggcgat cgggtgacca tgacctgcag cgccagcagc     2040

tccgtgtcct acatgaactg gtaccagcag aagcccggca aggctcccaa gaggtggatt     2100

tacgactcca gcaagctggc ctctggtgtc cccagcaggt tctctggtag cggcagcggc     2160

acagactaca ccctgaccat ctcctccctg cagcccgacg atttcgccac ctactattgc     2220

cagcagtggt cccggaatcc ccctaccttt ggcggcggca ccaaggtgga gatcaagagg     2280

agctaa                                                                2286


<210>  206
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC471 Anti-PSMA X anti-CD3 bispecific molecule

<400>  206

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ser Gln Val Gln Leu 
                485                 490                 495     


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
            500                 505                 510         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp 
        515                 520                 525             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
    530                 535                 540                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val 
545                 550                 555                 560 


Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                565                 570                 575     


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln 
            580                 585                 590         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
        595                 600                 605             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                645                 650                 655     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            660                 665                 670         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        675                 680                 685             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    690                 695                 700                 


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
705                 710                 715                 720 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val 
                725                 730                 735     


Glu Ile Lys Arg Ser 
            740     


<210>  207
<211>  2307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR243 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  207
atggaggctc ccgctcagct gctgttcctc ctgctgctct ggctgcccga caccacaggc       60

gacatccaga tgacccagtc cccttcctcc ctgtccgcta gcgtgggcga tagggtgacc      120

atcaactgcc aggcctccca gtccattgac tccaatctgg cctggttcca gcagaagccc      180

ggacagcccc ccaagctgct gatttacagg gcctccaacc tggcttccgg cgtgcctgac      240

aggttctccg gatccggcag cggcaccgac ttcaccctga ccatctcctc cctggaggcc      300

gaggatgtcg ccacctacta ctgtctgggc ggcgtgggcg ctgtgagcta tcggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggcggcggcg gcagcggcgg cggcggcagc      420

ggcggcggag gctccggcgg cggcggcagc gaggtgcagc tggtggaaag cggaggaggc      480

ctggtgcagc ctggaaggtc cctgaggctg tcctgcacag ccagcggctc cgacatcaac      540

gactacccca tcacctgggt gaggcaggct cctggccagg gcctggaatg gatcggcttt      600

atcaacagcg gcggcagcac ctggtatgct tcctgggtga agggccggtt caccattagc      660

agggacgact ccaagtccat tgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact actgcgccag gggctacagc acctattacc gggactttaa catctggggc      780

cagggcacac tggtcaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttccggag gagggggttc aggtggggga ggttctggcg gcgggggaag cccttcacag     1560

gtgcaactgg tgcagagtgg acccgaggtt aaaaaaccag ggtcctccgt taaggttagc     1620

tgcaaagcct ctggctacac attttccagg agtacaatgc actgggtgag gcaggctcct     1680

ggacagggac tcgagtggat cgggtatatc aacccatcta gcgcctatac caattacaac     1740

caaaagttta aggaccgagt taccattacc gctgacaaat ccaccagtac agcttatatg     1800

gagctgtcat ctcttaggtc cgaggacact gctgtttatt actgcgctcg tcctcaggtt     1860

cactatgact ataatggttt tccctactgg ggtcagggaa ccctggtgac tgtctcttct     1920

ggcggtggag gcagcggtgg gggtgggtct ggaggcggtg gcagtggcgg cggaggctct     1980

gatattcaga tgactcagtc tcctagcact ctcagcgcca gcgtggggga tcgtgtgaca     2040

atgacttgct ccgctagcag tagtgtgtct tacatgaatt ggtatcagca gaagcccggg     2100

aaagcaccta agcgctggat ctatgactct tccaagctgg caagtggtgt cccctcacgg     2160

ttctctggct caggttctgg tactgactat actttgacta tctcctccct ccagcccgat     2220

gatttcgcta cctattattg tcagcagtgg agccgtaacc cacccacttt cggaggcggt     2280

accaaagtgg agatcaagag gtcatga                                         2307


<210>  208
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR243 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  208

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asp Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val Gly Ala Val Ser 
                85                  90                  95      


Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Asp Ile Asn 
145                 150                 155                 160 


Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe Asn Ile Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Pro Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            500                 505                 510         


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        515                 520                 525             


Ser Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    530                 535                 540                 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn 
545                 550                 555                 560 


Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                565                 570                 575     


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            580                 585                 590         


Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro 
        595                 600                 605             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
                645                 650                 655     


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            660                 665                 670         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        675                 680                 685             


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    690                 695                 700                 


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
705                 710                 715                 720 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                725                 730                 735     


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser 
            740                 745             


<210>  209
<211>  2289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC266 Anti-PSMA X anti-CD3 bispecific molecule

<400>  209
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

gagtctgggg gcggagtggt gcagcctggg cggtcactga ggctgtcctg caaggcttct     1620

ggctacacct ttactagatc tacgatgcac tgggtaaggc aggcccctgg acaaggtctg     1680

gaatggattg gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacaggttca caatcagcgc agacaaatcc aagagcacag ccttcctgca gatggacagc     1800

ctgaggcccg aggacaccgg cgtctatttc tgtgcacggc cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaagggact cccgtcactg tctctagcgg tggcggaggg     1920

tctgggggtg gcggatccgg aggtggtggc tctgcacaag acatccagat gacccagtct     1980

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     2040

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcccccaa aagatggatt     2100

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     2160

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     2220

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacatcc     2280

tccagctaa                                                             2289


<210>  210
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC266 Anti-PSMA X anti-CD3 bispecific molecule

<400>  210

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
            500                 505                 510         


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu 
                565                 570                 575     


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                645                 650                 655     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            660                 665                 670         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        675                 680                 685             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    690                 695                 700                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
705                 710                 715                 720 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                725                 730                 735     


Gln Ile Thr Ser Ser Ser 
            740         


<210>  211
<211>  2301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR206 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  211
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag c                                               2301


<210>  212
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR206 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  212

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser 
        35                  40                  45              


Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val 
            100                 105                 110         


Gly Ala Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
                165                 170                 175     


Ser Asp Ile Asn Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp 
        195                 200                 205             


Tyr Ala Ser Trp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
    210                 215                 220                 


Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe 
                245                 250                 255     


Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Pro Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
        515                 520                 525             


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
    530                 535                 540                 


Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala 
545                 550                 555                 560 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
                565                 570                 575     


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala 
            580                 585                 590         


Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
        595                 600                 605             


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp 
    610                 615                 620                 


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            660                 665                 670         


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
        675                 680                 685             


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
    690                 695                 700                 


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
705                 710                 715                 720 


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
                725                 730                 735     


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
            740                 745                 750         


Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
        755                 760                 765         


<210>  213
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR207 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  213
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggcaagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgccctcc      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctgcagccc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggcaagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtgcaatc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc     1620

tcctgcaagg cttctggata taccttcagc agatctacga tgcactgggt gcgacaggcc     1680

cctggacaag ggcttgagtg gataggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatccacgag cacagcctac     1800

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc     1920

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga     1980

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc     2040

accatgactt gcagtgccag ctcaagtgta agttacatga actggtatca gcagaaacca     2100

gggaaagccc ctaagagatg gatttatgac tcatccaaac tggcttctgg ggtcccatca     2160

aggttcagcg gcagtggatc tgggacagat tatactctca ccatcagcag cctgcagcct     2220

gatgattttg caacttatta ctgccaacag tggagtcgta acccacccac tttcggcgga     2280

gggaccaagg tggagatcaa acggtcctcc agc                                  2313


<210>  214
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR207 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  214

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser 
        35                  40                  45              


Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val 
            100                 105                 110         


Gly Ala Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
                165                 170                 175     


Ser Asp Ile Asn Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp 
        195                 200                 205             


Tyr Ala Ser Trp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
    210                 215                 220                 


Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe 
                245                 250                 255     


Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
        515                 520                 525             


Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
    530                 535                 540                 


Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala 
545                 550                 555                 560 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
                565                 570                 575     


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala 
            580                 585                 590         


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
        595                 600                 605             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp 
    610                 615                 620                 


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu 
            660                 665                 670         


Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser 
        675                 680                 685             


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    690                 695                 700                 


Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser 
705                 710                 715                 720 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                725                 730                 735     


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            740                 745                 750         


Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        755                 760                 765             


Ser Ser Ser 
    770     


<210>  215
<211>  2301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR208 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  215
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggccagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgcccgac      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctggaggcc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggccagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg     1620

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc     1680

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc     1800

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct     1920

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc     1980

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc     2040

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc     2100

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt     2160

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc     2220

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag     2280

ctacaaatta catcctccag c                                               2301


<210>  216
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR208 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  216

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser 
        35                  40                  45              


Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val 
            100                 105                 110         


Gly Ala Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
                165                 170                 175     


Ser Asp Ile Asn Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp 
        195                 200                 205             


Tyr Ala Ser Trp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
    210                 215                 220                 


Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe 
                245                 250                 255     


Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Pro Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
        515                 520                 525             


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
    530                 535                 540                 


Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala 
545                 550                 555                 560 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
                565                 570                 575     


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala 
            580                 585                 590         


Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
        595                 600                 605             


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp 
    610                 615                 620                 


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            660                 665                 670         


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
        675                 680                 685             


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
    690                 695                 700                 


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
705                 710                 715                 720 


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
                725                 730                 735     


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
            740                 745                 750         


Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
        755                 760                 765         


<210>  217
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR209 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  217
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc      120

atcaactgcc aggcctccca gtccatcgac tccaacctgg cctggttcca gcagaagccc      180

ggccagcccc ccaagctgct gatctaccgg gcctccaacc tggcctccgg cgtgcccgac      240

cggttctccg gctccggctc cggcaccgac ttcaccctga ccatctcctc cctggaggcc      300

gaggacgtgg ccacctacta ctgcctgggc ggcgtgggcg ccgtgtccta ccggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gctccggtgg cggcggatct gaggtgcagc tggtggagtc cggcggcggc      480

ctggtgcagc ccggccggtc cctgcggctg tcctgcaccg cctccggctc cgacatcaac      540

gactacccca tcacctgggt gcggcaggcc cccggccagg gcctggagtg gatcggcttc      600

atcaactccg gcggctccac ctggtacgcc tcctgggtga agggccggtt caccatctcc      660

cgggacgact ccaagtccat cgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact attgcgcccg gggctactcc acctactacc gggacttcaa catctggggc      780

cagggcaccc tggtgaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttctggtg gaggcggttc aggcggaggt ggctccggcg gtggcggatc gccgggctct     1560

caggtccagc tggtgcaatc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc     1620

tcctgcaagg cttctggata taccttcagc agatctacga tgcactgggt gcgacaggcc     1680

cctggacaag ggcttgagtg gataggatac attaatccta gcagtgctta tactaattac     1740

aatcagaaat tcaaggacag agtcacgatt accgcggaca aatccacgag cacagcctac     1800

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccccaa     1860

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc     1920

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga     1980

tctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc     2040

accatgactt gcagtgccag ctcaagtgta agttacatga actggtatca gcagaaacca     2100

gggaaagccc ctaagagatg gatttatgac tcatccaaac tggcttctgg ggtcccatca     2160

aggttcagcg gcagtggatc tgggacagat tatactctca ccatcagcag cctgcagcct     2220

gatgattttg caacttatta ctgccaacag tggagtcgta acccacccac tttcggcgga     2280

gggaccaagg tggagatcaa acggtcctcc agc                                  2313


<210>  218
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR209 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  218

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser 
        35                  40                  45              


Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val 
            100                 105                 110         


Gly Ala Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
                165                 170                 175     


Ser Asp Ile Asn Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp 
        195                 200                 205             


Tyr Ala Ser Trp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
    210                 215                 220                 


Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe 
                245                 250                 255     


Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
        515                 520                 525             


Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
    530                 535                 540                 


Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala 
545                 550                 555                 560 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
                565                 570                 575     


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala 
            580                 585                 590         


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
        595                 600                 605             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp 
    610                 615                 620                 


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu 
            660                 665                 670         


Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser 
        675                 680                 685             


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    690                 695                 700                 


Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser 
705                 710                 715                 720 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                725                 730                 735     


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            740                 745                 750         


Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        755                 760                 765             


Ser Ser Ser 
    770     


<210>  219
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR231 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  219
atggaggcac ccgcccagct gctgttcttg ttgctgctgt ggctccctga taccaccgga       60

gacatccaga tgacccaatc cccttctagt ctctccgcta gcgtcggaga ccgcgtgacc      120

atcaattgtc aagcatctca gagtattgac agcaatctcg cctggtttca gcagaagcca      180

ggaaagccac ccaagctcct gatttatagg gctagcaacc tggcttctgg tgtccctagt      240

aggttcagcg gctctgggag tggcacagac ttcaccctga ccattagtag tctgcagccc      300

gaagatgtcg ctacctatta ctgcctcgga ggagtgggtg ccgtttctta tcgcacctca      360

tttggaggtg gcaccaaagt ggagatcaaa ggtggtggcg gctccggggg tggcgggtca      420

ggggggggag ggtctggagg cggcggatca gaagttcagc tggtggaatc tggaggaggt      480

ctggtgcagc caggcaggtc cctccggctg agctgcactg catccggctc tgacattaat      540

gactacccta tcacctgggt gaggcaggcc cccggtaaag gcctggagtg gatcgggttc      600

atcaattctg gtggatctac ttggtacgca agctgggtga aaggacgctt cacaattagt      660

agagacgact ctaagtctat cgcatatctg cagatgaata gcttgaagac agaggacacc      720

gccgtgtact attgtgcaag aggatactcc acttactacc gcgatttcaa tatctggggc      780

cagggaaccc tggtgacagt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttccggag gcggcggctc cggcggcggc ggcagcggcg gcggcggcag ccccggatcc     1560

caggtgcagc tggtgcagtc tggtcctgag gtgaaaaagc ctggctccag cgtgaaggtg     1620

tcctgcaagg ccagcggata cacctttagc cggtccacca tgcattgggt gaggcaggct     1680

cctggacagg gcctggagtg gatcggctac atcaacccca gcagcgctta taccaactac     1740

aatcagaagt ttaaggaccg ggtgaccatc accgccgata agtccaccag caccgcctac     1800

atggagctgt ccagcctgag gagcgaggat accgccgtgt actattgcgc ccggccccag     1860

gtccattacg actacaacgg cttcccctat tggggccagg gaaccctggt gaccgtgtcc     1920

agcggaggcg gcggcagcgg cggcggcggc agcggcggag gaggcagcgg cggaggaggc     1980

tccgacattc agatgaccca gtccccctcc accctgtccg ctagcgtggg cgatcgggtg     2040

accatgacct gcagcgccag cagctccgtg tcctacatga actggtacca gcagaagccc     2100

ggcaaggctc ccaagaggtg gatttacgac tccagcaagc tggcctctgg tgtccccagc     2160

aggttctctg gtagcggcag cggcacagac tacaccctga ccatctcctc cctgcagccc     2220

gacgatttcg ccacctacta ttgccagcag tggtcccgga atccccctac ctttggcggc     2280

ggcaccaagg tggagatcaa gaggagctcc agc                                  2313


<210>  220
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR231 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  220

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser 
        35                  40                  45              


Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val 
            100                 105                 110         


Gly Ala Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
                165                 170                 175     


Ser Asp Ile Asn Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp 
        195                 200                 205             


Tyr Ala Ser Trp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
    210                 215                 220                 


Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe 
                245                 250                 255     


Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
        515                 520                 525             


Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
    530                 535                 540                 


Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala 
545                 550                 555                 560 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
                565                 570                 575     


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala 
            580                 585                 590         


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
        595                 600                 605             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp 
    610                 615                 620                 


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu 
            660                 665                 670         


Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser 
        675                 680                 685             


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    690                 695                 700                 


Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser 
705                 710                 715                 720 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                725                 730                 735     


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            740                 745                 750         


Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        755                 760                 765             


Ser Ser Ser 
    770     


<210>  221
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR233 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  221
atggaggctc ccgctcagct gctgttcctc ctgctgctct ggctgcccga caccacaggc       60

gacatccaga tgacccagtc cccttcctcc ctgtccgcta gcgtgggcga tagggtgacc      120

atcaactgcc aggcctccca gtccattgac tccaatctgg cctggttcca gcagaagccc      180

ggacagcccc ccaagctgct gatttacagg gcctccaacc tggcttccgg cgtgcctgac      240

aggttctccg gatccggcag cggcaccgac ttcaccctga ccatctcctc cctggaggcc      300

gaggatgtcg ccacctacta ctgtctgggc ggcgtgggcg ctgtgagcta tcggacctcc      360

ttcggcggcg gcaccaaggt ggagatcaag ggcggcggcg gcagcggcgg cggcggcagc      420

ggcggcggag gctccggcgg cggcggcagc gaggtgcagc tggtggaaag cggaggaggc      480

ctggtgcagc ctggaaggtc cctgaggctg tcctgcacag ccagcggctc cgacatcaac      540

gactacccca tcacctgggt gaggcaggct cctggccagg gcctggaatg gatcggcttt      600

atcaacagcg gcggcagcac ctggtatgct tcctgggtga agggccggtt caccattagc      660

agggacgact ccaagtccat tgcctacctg cagatgaact ccctgaagac cgaggacacc      720

gccgtgtact actgcgccag gggctacagc acctattacc gggactttaa catctggggc      780

cagggcacac tggtcaccgt gtcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggaat acaagtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggttccggag gcggcggctc cggcggcggc ggcagcggcg gcggcggcag ccccggatcc     1560

caggtgcagc tggtgcagtc tggtcctgag gtgaaaaagc ctggctccag cgtgaaggtg     1620

tcctgcaagg ccagcggata cacctttagc cggtccacca tgcattgggt gaggcaggct     1680

cctggacagg gcctggagtg gatcggctac atcaacccca gcagcgctta taccaactac     1740

aatcagaagt ttaaggaccg ggtgaccatc accgccgata agtccaccag caccgcctac     1800

atggagctgt ccagcctgag gagcgaggat accgccgtgt actattgcgc ccggccccag     1860

gtccattacg actacaacgg cttcccctat tggggccagg gaaccctggt gaccgtgtcc     1920

agcggaggcg gcggcagcgg cggcggcggc agcggcggag gaggcagcgg cggaggaggc     1980

tccgacattc agatgaccca gtccccctcc accctgtccg ctagcgtggg cgatcgggtg     2040

accatgacct gcagcgccag cagctccgtg tcctacatga actggtacca gcagaagccc     2100

ggcaaggctc ccaagaggtg gatttacgac tccagcaagc tggcctctgg tgtccccagc     2160

aggttctctg gtagcggcag cggcacagac tacaccctga ccatctcctc cctgcagccc     2220

gacgatttcg ccacctacta ttgccagcag tggtcccgga atccccctac ctttggcggc     2280

ggcaccaagg tggagatcaa gaggagctcc agc                                  2313


<210>  222
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR233 Anti-ROR1 X anti-CD3 bispecific molecule

<400>  222

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser 
        35                  40                  45              


Ile Asp Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Gly Val 
            100                 105                 110         


Gly Ala Val Ser Tyr Arg Thr Ser Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
                165                 170                 175     


Ser Asp Ile Asn Asp Tyr Pro Ile Thr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Ile Gly Phe Ile Asn Ser Gly Gly Ser Thr Trp 
        195                 200                 205             


Tyr Ala Ser Trp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
    210                 215                 220                 


Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ser Thr Tyr Tyr Arg Asp Phe 
                245                 250                 255     


Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Pro Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
        515                 520                 525             


Pro Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
    530                 535                 540                 


Ser Gly Tyr Thr Phe Ser Arg Ser Thr Met His Trp Val Arg Gln Ala 
545                 550                 555                 560 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
                565                 570                 575     


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala 
            580                 585                 590         


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
        595                 600                 605             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp 
    610                 615                 620                 


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu 
            660                 665                 670         


Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser 
        675                 680                 685             


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    690                 695                 700                 


Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser 
705                 710                 715                 720 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                725                 730                 735     


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            740                 745                 750         


Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        755                 760                 765             


Ser Ser Ser 
    770     


