                               SEQUENCE LISTING

<110> THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120> STRUCTURE BASED DESIGN OF THERAPEUTICS BASED ON HIGH-RESOLUTION 
      STRUCTURES OF NOVEL PHOSPHATIDYLINOSITOL-PHOSPHATE SYNTHASE 
      (PIPS) CONSTRUCTS

<130> 01001/003791-WO0

<140>
<141>

<150> 62/221,356
<151> 2015-09-21

<160> 75    

<170> PatentIn version 3.5

<210> 1
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 1
tccctcatcg gttctggatc atccaatgtc tacctgatga cc                          42


<210> 2
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
atccgttatc cacttccaat gttacggttc gctcgtttcc gg                          42


<210> 3
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 3
tccctcatcg gttctggatc aagtggtctg ctgtcccgtg aa                          42


<210> 4
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
atccgttatc cacttccaat gttacggttg attcgtttcg gc                          42


<210> 5
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
tccctcatcg gttctggatc atctaacctg ttcctgatgt cg                          42


<210> 6
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
atccgttatc cacttccaat gttaagacgc acccggatcc gt                          42


<210> 7
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
tccctcatcg gttctggatc aagtaaagtg ccgttcctga gc                          42


<210> 8
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
atccgttatc cacttccaat gttacggagc atcggaacca cg                          42


<210> 9
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
tccctcatcg gttctggatc atcgaaagcc ccgttcctga gt                          42


<210> 10
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
atccgttatc cacttccaat gttagcgttg cgttttaccc gg                          42


<210> 11
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
tccctcatcg gttctggatc atcgaaactg ccgttcctgt ct                          42


<210> 12
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
atccgttatc cacttccaat gttagcgatc acctttgccc gg                          42


<210> 13
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
tccctcatcg gttctggatc actgtccatt cgtggtcgtg cc                          42


<210> 14
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
atccgttatc cacttccaat gttagcgtgc atctgcaccc gg                          42


<210> 15
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
tccctcatcg gttctggatc actgtcgttc ttcggtcgtg cc                          42


<210> 16
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
atccgttatc cacttccaat gttattgcac gcttgcctgg cc                          42


<210> 17
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
tccctcatcg gttctggatc actgtcgttc ttcggtcgtg aa                          42


<210> 18
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
atccgttatc cacttccaat gttagcgcgc ttcacccgca gc                          42


<210> 19
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
tccctcatcg gttctggatc actgaatatc tttgctcgtg cc                          42


<210> 20
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
atccgttatc cacttccaat gttacggttg ggcaccgccc gc                          42


<210> 21
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
tccctcatcg gttctggatc actggaacgc tttcgtgctg gt                          42


<210> 22
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
atccgttatc cacttccaat gttacggagc ttttgcttga cg                          42


<210> 23
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
tccctcatcg gttctggatc actgaatacc attgcccgtg cc                          42


<210> 24
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
atccgttatc cacttccaat gttagctggt ttcgtggttt tc                          42


<210> 25
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
tccctcatcg gttctggatc actgaataaa tacgcccgtg gt                          42


<210> 26
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
atccgttatc cacttccaat gttaggaagc ggtccaagct tt                          42


<210> 27
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
tccctcatcg gttctggatc actgaatcgt tatgctcgtg ct                          42


<210> 28
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
atccgttatc cacttccaat gttaggacgt cgccggggta ct                          42


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
cattggaagt ggataacgga t                                                 21


<210> 30
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
tgatccagaa ccgatgaggg agctcagaag gag                                    33


<210> 31
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
ctgagctccc tcatcggttc actgaataaa tacgcc                                 36


<210> 32
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
ggcgtattta ttcagtgaac cgatgaggga gctcag                                 36


<210> 33
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
atcggttctc gtggtctgtt cgctgctatc                                        30


<210> 34
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
cagaccacga gaaccgatga gggagctcag                                        30


<210> 35
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
atcggttctc gcgctgcttt tcgtcgtatc acc                                    33


<210> 36
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
agcgcgagaa ccgatgaggg agctcagaag gag                                    33


<210> 37
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
ttccaatcca atgccatgag caagctgccc ttc                                    33


<210> 38
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
tatccacttc caatgtcacc ggtcgccctt tcc                                    33


<210> 39
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
cattggaagt ggataacgga tccg                                              24


<210> 40
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
ggcattggat tggaagtaca ggtt                                              24


<210> 41
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
atgttggtct gacgccggcc gtggttacca ttctg                                  35


<210> 42
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
cagaatggta accacggccg gcgtcagacc aacat                                  35


<210> 43
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
cgtgctgttt gatgcgctgg acggtgcaat ggca                                   34


<210> 44
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
tgccattgca ccgtccagcg catcaaacag cacg                                   34


<210> 45
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
ttcgtgctgt ttgatttcct ggacggtgca atg                                    33


<210> 46
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
cattgcaccg tccaggaaat caaacagcac gaa                                    33


<210> 47
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
ttcgtgctgt ttgattggct ggacggtgca atg                                    33


<210> 48
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
cattgcaccg tccagccaat caaacagcac gaa                                    33


<210> 49
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
gtgctgtttg atatgtggga cggtgcaatg gc                                     32


<210> 50
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
gccattgcac cgtcccacat atcaaacagc ac                                     32


<210> 51
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
ctggatgcga cgtgcaaccg catttctgat ggc                                    33


<210> 52
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
gccatcagaa atgcggttgc acgtcgcatc cag                                    33


<210> 53
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
gacgagccag gttattgctt atatcaaagc ac                                     32


<210> 54
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
gtgctttgat ataagcaata acctggctcg tc                                     32


<210> 55
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
ggttatttct tatatcgcag cacgtgctga agc                                    33


<210> 56
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
gcttcagcac gtgctgcgat ataagaaata acc                                    33


<210> 57
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
ggtttcattg aacgtgcgga acgcctgatt atc                                    33


<210> 58
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
gataatcagg cgttccgcac gttcaatgaa acc                                    33


<210> 59
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
ggtttcattg aacgtgttga acgcctgatt atc                                    33


<210> 60
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
gataatcagg cgttcaacac gttcaatgaa acc                                    33


<210> 61
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 61
ggtttcattg aacgttggga acgcctgatt atc                                    33


<210> 62
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 62
gataatcagg cgttcccaac gttcaatgaa acc                                    33


<210> 63
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 63
cattgaacgt ccggaagccc tgattatcgt cctg                                   34


<210> 64
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
caggacgata atcagggctt ccggacgttc aatg                                   34


<210> 65
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 65
attgaacgtc cggaacagct gattatcgtc ctg                                    33


<210> 66
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 66
caggacgata atcagctgtt ccggacgttc aat                                    33


<210> 67
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 67
catcacctgc gtccaagctc tgcacaccgt gtgg                                   34


<210> 68
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
ccacacggtg tgcagagctt ggacgcaggt gatg                                   34


<210> 69
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 69
atcacctgcg tccaacagct gcacaccgtg tgg                                    33


<210> 70
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 70
ccacacggtg tgcagctgtt ggacgcaggt gat                                    33


<210> 71
<211> 343
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Met Arg Leu Ala Tyr Val Lys Asn His Glu Ile Tyr Gly Glu Lys Leu 
1               5                   10                  15      


Leu Gly Leu Thr Leu Arg Glu Arg Ile Glu Lys Thr Leu Gln Arg Ala 
            20                  25                  30          


Gly Phe Asp Val Arg Phe Phe Asp Glu Leu Ser Leu Glu Glu Ala Glu 
        35                  40                  45              


Asp Tyr Leu Ile Ile Leu Glu Pro Val Leu Ile Leu Glu Arg Asp Leu 
    50                  55                  60                  


Leu Leu Glu Gly Arg Lys Ile Leu Val Ser Asp Gly Phe Thr Val Gly 
65                  70                  75                  80  


Tyr Phe Phe Gly Gly Asp Phe Arg Thr Val Phe Asp Gly Asn Leu Gln 
                85                  90                  95      


Ser Ser Ile Glu Lys Tyr Leu Ser Leu Asn Asn Leu Glu Ser Tyr Glu 
            100                 105                 110         


Ile Trp Ala Ile Lys Leu Ser Asn Asp Asn Leu Lys Thr Ala Glu Lys 
        115                 120                 125             


Leu Leu Leu Ser Ser Leu Ile Gly Ser Gly Ser Leu Asn Lys Tyr Ala 
    130                 135                 140                 


Arg Gly Leu Phe Ala Ala Ile Phe Leu Pro Ile Ala Arg Leu Leu Ala 
145                 150                 155                 160 


Asp Trp Gly Val Ser Pro Asp Ala Val Thr Val Val Gly Thr Leu Gly 
                165                 170                 175     


Val Met Ala Gly Ala Leu Ile Phe Tyr Pro Met Gly Gln Leu Phe Trp 
            180                 185                 190         


Gly Thr Val Val Ile Thr Val Phe Val Phe Ser Asp Ile Ile Asp Gly 
        195                 200                 205             


Leu Met Ala Arg Leu Leu Phe Arg Glu Gly Pro Trp Gly Ala Phe Leu 
    210                 215                 220                 


Asp Ser Tyr Leu Asp Arg Val Gly Asp Ser Ser Val Phe Thr Gly Ile 
225                 230                 235                 240 


Val Ile Trp Phe Phe Leu Gly Gly Ala Asn Pro Thr Ile Ala Ile Leu 
                245                 250                 255     


Ala Leu Ile Cys Leu Val Leu Ser Ser Leu Val Ser Tyr Ser Lys Ala 
            260                 265                 270         


Arg Ala Glu Gly Leu Gly Leu Thr Ala Asn Val Gly Ile Ala Glu Arg 
        275                 280                 285             


Ser Glu Arg Leu Val Val Val Leu Val Ala Thr Gly Leu Val Gly Leu 
    290                 295                 300                 


Gly Ile Pro Ser Trp Val Leu Leu Val Val Leu Ile Val Leu Ala Ile 
305                 310                 315                 320 


Ala Ser Val Val Thr Ile Phe Gln Arg Val Leu Thr Val Arg Glu Gln 
                325                 330                 335     


Ala Lys Ala Trp Thr Ala Ser 
            340             


<210> 72
<211> 336
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Met Arg Leu Ala Tyr Val Lys Asn His Glu Ile Tyr Gly Glu Lys Leu 
1               5                   10                  15      


Leu Gly Leu Thr Leu Arg Glu Arg Ile Glu Lys Thr Leu Gln Arg Ala 
            20                  25                  30          


Gly Phe Asp Val Arg Phe Phe Asp Glu Leu Ser Leu Glu Glu Ala Glu 
        35                  40                  45              


Asp Tyr Leu Ile Ile Leu Glu Pro Val Leu Ile Leu Glu Arg Asp Leu 
    50                  55                  60                  


Leu Leu Glu Gly Arg Lys Ile Leu Val Ser Asp Gly Phe Thr Val Gly 
65                  70                  75                  80  


Tyr Phe Phe Gly Gly Asp Phe Arg Thr Val Phe Asp Gly Asn Leu Gln 
                85                  90                  95      


Ser Ser Ile Glu Lys Tyr Leu Ser Leu Asn Asn Leu Glu Ser Tyr Glu 
            100                 105                 110         


Ile Trp Ala Ile Lys Leu Ser Asn Asp Asn Leu Lys Thr Ala Glu Lys 
        115                 120                 125             


Leu Leu Leu Ser Ser Leu Ile Gly Ser Arg Gly Leu Phe Ala Ala Ile 
    130                 135                 140                 


Phe Leu Pro Ile Ala Arg Leu Leu Ala Asp Trp Gly Val Ser Pro Asp 
145                 150                 155                 160 


Ala Val Thr Val Val Gly Thr Leu Gly Val Met Ala Gly Ala Leu Ile 
                165                 170                 175     


Phe Tyr Pro Met Gly Gln Leu Phe Trp Gly Thr Val Val Ile Thr Val 
            180                 185                 190         


Phe Val Phe Ser Asp Ile Ile Asp Gly Leu Met Ala Arg Leu Leu Phe 
        195                 200                 205             


Arg Glu Gly Pro Trp Gly Ala Phe Leu Asp Ser Tyr Leu Asp Arg Val 
    210                 215                 220                 


Gly Asp Ser Ser Val Phe Thr Gly Ile Val Ile Trp Phe Phe Leu Gly 
225                 230                 235                 240 


Gly Ala Asn Pro Thr Ile Ala Ile Leu Ala Leu Ile Cys Leu Val Leu 
                245                 250                 255     


Ser Ser Leu Val Ser Tyr Ser Lys Ala Arg Ala Glu Gly Leu Gly Leu 
            260                 265                 270         


Thr Ala Asn Val Gly Ile Ala Glu Arg Ser Glu Arg Leu Val Val Val 
        275                 280                 285             


Leu Val Ala Thr Gly Leu Val Gly Leu Gly Ile Pro Ser Trp Val Leu 
    290                 295                 300                 


Leu Val Val Leu Ile Val Leu Ala Ile Ala Ser Val Val Thr Ile Phe 
305                 310                 315                 320 


Gln Arg Val Leu Thr Val Arg Glu Gln Ala Lys Ala Trp Thr Ala Ser 
                325                 330                 335     


<210> 73
<211> 205
<212> PRT
<213> Renibacterium salmoninarum

<400> 73
Met Leu Asn Lys Tyr Ala Arg Gly Leu Phe Ala Ala Ile Phe Met Pro 
1               5                   10                  15      


Ile Ala Arg Leu Leu Val Arg Trp Gly Val Ser Pro Asp Ala Val Thr 
            20                  25                  30          


Val Val Gly Thr Leu Gly Val Met Ala Gly Ala Leu Ile Phe Tyr Pro 
        35                  40                  45              


Met Gly Gln Leu Phe Trp Gly Thr Val Val Ile Thr Val Phe Val Phe 
    50                  55                  60                  


Ser Asp Ile Ile Asp Gly Leu Met Ala Arg Gln Leu Asp Arg Pro Gly 
65                  70                  75                  80  


Pro Trp Gly Ala Phe Leu Asp Ser Tyr Leu Asp Arg Val Gly Asp Ser 
                85                  90                  95      


Ser Val Phe Thr Gly Ile Val Ile Trp Phe Phe Leu Gly Gly Ala Asn 
            100                 105                 110         


Pro Thr Ile Ala Ile Leu Ala Leu Ile Cys Leu Val Leu Ser Ser Leu 
        115                 120                 125             


Val Ser Tyr Ser Lys Ala Arg Ala Glu Gly Leu Gly Leu Thr Ala Asn 
    130                 135                 140                 


Val Gly Ile Ala Glu Arg Ser Glu Arg Leu Val Val Val Leu Val Ala 
145                 150                 155                 160 


Thr Gly Leu Val Gly Leu Gly Ile Pro Ser Trp Val Leu Leu Val Val 
                165                 170                 175     


Leu Ile Val Leu Ala Ile Ala Ser Val Val Thr Ile Phe Gln Arg Val 
            180                 185                 190         


Leu Thr Val Arg Glu Gln Ala Lys Ala Trp Thr Ala Ser 
        195                 200                 205 


<210> 74
<211> 416
<212> PRT
<213> Homo sapiens

<400> 74
Met Ser Gly His Arg Ser Thr Arg Lys Arg Cys Gly Asp Ser His Pro 
1               5                   10                  15      


Glu Ser Pro Val Gly Phe Gly His Met Ser Thr Thr Gly Cys Val Leu 
            20                  25                  30          


Asn Lys Leu Phe Gln Leu Pro Thr Pro Pro Leu Ser Arg His Gln Leu 
        35                  40                  45              


Lys Arg Leu Glu Glu His Arg Tyr Gln Ser Ala Gly Arg Ser Leu Leu 
    50                  55                  60                  


Glu Pro Leu Met Gln Gly Tyr Trp Glu Trp Leu Val Arg Arg Val Pro 
65                  70                  75                  80  


Ser Trp Ile Ala Pro Asn Leu Ile Thr Ile Ile Gly Leu Ser Ile Asn 
                85                  90                  95      


Ile Cys Thr Thr Ile Leu Leu Val Phe Tyr Cys Pro Thr Ala Thr Glu 
            100                 105                 110         


Gln Ala Pro Leu Trp Ala Tyr Ile Ala Cys Ala Cys Gly Leu Phe Ile 
        115                 120                 125             


Tyr Gln Ser Leu Asp Ala Ile Asp Gly Lys Gln Ala Arg Arg Thr Asn 
    130                 135                 140                 


Ser Ser Ser Pro Leu Gly Glu Leu Phe Asp His Gly Cys Asp Ser Leu 
145                 150                 155                 160 


Ser Thr Val Phe Val Val Leu Gly Thr Cys Ile Ala Val Gln Leu Gly 
                165                 170                 175     


Thr Asn Pro Asp Trp Met Phe Phe Cys Cys Phe Ala Gly Thr Phe Met 
            180                 185                 190         


Phe Tyr Cys Ala His Trp Gln Thr Tyr Val Ser Gly Thr Leu Arg Phe 
        195                 200                 205             


Gly Ile Ile Asp Val Thr Glu Val Gln Ile Phe Ile Ile Ile Met His 
    210                 215                 220                 


Leu Leu Ala Val Ile Gly Gly Pro Pro Phe Trp Gln Ser Met Ile Pro 
225                 230                 235                 240 


Val Leu Asn Ile Gln Met Lys Ile Phe Pro Ala Leu Cys Thr Val Ala 
                245                 250                 255     


Gly Thr Ile Phe Ser Cys Thr Asn Tyr Phe Arg Val Ile Phe Thr Gly 
            260                 265                 270         


Gly Val Gly Lys Asn Gly Ser Thr Ile Ala Gly Thr Ser Val Leu Ser 
        275                 280                 285             


Pro Phe Leu His Ile Gly Ser Val Ile Thr Leu Ala Ala Met Ile Tyr 
    290                 295                 300                 


Lys Lys Ser Ala Val Gln Leu Phe Glu Lys His Pro Cys Leu Tyr Ile 
305                 310                 315                 320 


Leu Thr Phe Gly Phe Val Ser Ala Lys Ile Thr Asn Lys Leu Val Val 
                325                 330                 335     


Ala His Met Thr Lys Ser Glu Met His Leu His Asp Thr Ala Phe Ile 
            340                 345                 350         


Gly Pro Ala Leu Leu Phe Leu Asp Gln Tyr Phe Asn Ser Phe Ile Asp 
        355                 360                 365             


Glu Tyr Ile Val Leu Trp Ile Ala Leu Val Phe Ser Phe Phe Asp Leu 
    370                 375                 380                 


Ile Arg Tyr Cys Val Ser Val Cys Asn Gln Ile Ala Ser His Leu His 
385                 390                 395                 400 


Ile His Val Phe Arg Ile Lys Val Ser Thr Ala His Ser Asn His His 
                405                 410                 415     


<210> 75
<211> 217
<212> PRT
<213> Mycobacterium tuberculosis

<400> 75
Met Ser Lys Leu Pro Phe Leu Ser Arg Ala Ala Phe Ala Arg Ile Thr 
1               5                   10                  15      


Thr Pro Ile Ala Arg Gly Leu Leu Arg Val Gly Leu Thr Pro Asp Val 
            20                  25                  30          


Val Thr Ile Leu Gly Thr Thr Ala Ser Val Ala Gly Ala Leu Thr Leu 
        35                  40                  45              


Phe Pro Met Gly Lys Leu Phe Ala Gly Ala Cys Val Val Trp Phe Phe 
    50                  55                  60                  


Val Leu Phe Asp Met Leu Asp Gly Ala Met Ala Arg Glu Arg Gly Gly 
65                  70                  75                  80  


Gly Thr Arg Phe Gly Ala Val Leu Asp Ala Thr Cys Asp Arg Ile Ser 
                85                  90                  95      


Asp Gly Ala Val Phe Cys Gly Leu Leu Trp Trp Ile Ala Phe His Met 
            100                 105                 110         


Arg Asp Arg Pro Leu Val Ile Ala Thr Leu Ile Cys Leu Val Thr Ser 
        115                 120                 125             


Gln Val Ile Ser Tyr Ile Lys Ala Arg Ala Glu Ala Ser Gly Leu Arg 
    130                 135                 140                 


Gly Asp Gly Gly Phe Ile Glu Arg Pro Glu Arg Leu Ile Ile Val Leu 
145                 150                 155                 160 


Thr Gly Ala Gly Val Ser Asp Phe Pro Phe Val Pro Trp Pro Pro Ala 
                165                 170                 175     


Leu Ser Val Gly Met Trp Leu Leu Ala Val Ala Ser Val Ile Thr Cys 
            180                 185                 190         


Val Gln Arg Leu His Thr Val Trp Thr Ser Pro Gly Ala Ile Asp Arg 
        195                 200                 205             


Met Ala Ile Pro Gly Lys Gly Asp Arg 
    210                 215         


