                         SEQUENCE LISTING

<110>  Erasmus University Medical Center
       Surface Oncology, Inc.
 
<120>  ANTI-CD47 ANTIBODIES AND METHODS OF USE

<130>  SFO-001PC

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  2
<211>  5346
<212>  DNA
<213>  Homo sapiens

<400>  2
ggggagcagg cgggggagcg ggcgggaagc agtgggagcg cgcgtgcgcg cggccgtgca       60

gcctgggcag tgggtcctgc ctgtgacgcg cggcggcggt cggtcctgcc tgtaacggcg      120

gcggcggctg ctgctccaga cacctgcggc ggcggcggcg accccgcggc gggcgcggag      180

atgtggcccc tggtagcggc gctgttgctg ggctcggcgt gctgcggatc agctcagcta      240

ctatttaata aaacaaaatc tgtagaattc acgttttgta atgacactgt cgtcattcca      300

tgctttgtta ctaatatgga ggcacaaaac actactgaag tatacgtaaa gtggaaattt      360

aaaggaagag atatttacac ctttgatgga gctctaaaca agtccactgt ccccactgac      420

tttagtagtg caaaaattga agtctcacaa ttactaaaag gagatgcctc tttgaagatg      480

gataagagtg atgctgtctc acacacagga aactacactt gtgaagtaac agaattaacc      540

agagaaggtg aaacgatcat cgagctaaaa tatcgtgttg tttcatggtt ttctccaaat      600

gaaaatattc ttattgttat tttcccaatt tttgctatac tcctgttctg gggacagttt      660

ggtattaaaa cacttaaata tagatccggt ggtatggatg agaaaacaat tgctttactt      720

gttgctggac tagtgatcac tgtcattgtc attgttggag ccattctttt cgtcccaggt      780

gaatattcat taaagaatgc tactggcctt ggtttaattg tgacttctac agggatatta      840

atattacttc actactatgt gtttagtaca gcgattggat taacctcctt cgtcattgcc      900

atattggtta ttcaggtgat agcctatatc ctcgctgtgg ttggactgag tctctgtatt      960

gcggcgtgta taccaatgca tggccctctt ctgatttcag gtttgagtat cttagctcta     1020

gcacaattac ttggactagt ttatatgaaa tttgtggctt ccaatcagaa gactatacaa     1080

cctcctagga aagctgtaga ggaacccctt aatgcattca aagaatcaaa aggaatgatg     1140

aatgatgaat aactgaagtg aagtgatgga ctccgatttg gagagtagta agacgtgaaa     1200

ggaatacact tgtgtttaag caccatggcc ttgatgattc actgttgggg agaagaaaca     1260

agaaaagtaa ctggttgtca cctatgagac ccttacgtga ttgttagtta agtttttatt     1320

caaagcagct gtaatttagt taataaaata attatgatct atgttgtttg cccaattgag     1380

atccagtttt ttgttgttat ttttaatcaa ttaggggcaa tagtagaatg gacaatttcc     1440

aagaatgatg cctttcaggt cctagggcct ctggcctcta ggtaaccagt ttaaattggt     1500

tcagggtgat aactacttag cactgccctg gtgattaccc agagatatct atgaaaacca     1560

gtggcttcca tcaaaccttt gccaactcag gttcacagca gctttgggca gttatggcag     1620

tatggcatta gctgagaggt gtctgccact tctgggtcaa tggaataata aattaagtac     1680

aggcaggaat ttggttggga gcatcttgta tgatctccgt atgatgtgat attgatggag     1740

atagtggtcc tcattcttgg gggttgccat tcccacattc ccccttcaac aaacagtgta     1800

acaggtcctt cccagattta gggtactttt attgatggat atgttttcct tttattcaca     1860

taaccccttg aaaccctgtc ttgtcctcct gttacttgct tctgctgtac aagatgtagc     1920

accttttctc ctctttgaac atggtctagt gacacggtag caccagttgc aggaaggagc     1980

cagacttgtt ctcagagcac tgtgttcaca cttttcagca aaaatagcta tggttgtaac     2040

atatgtattc ccttcctctg atttgaaggc aaaaatctac agtgtttctt cacttctttt     2100

ctgatctggg gcatgaaaaa agcaagattg aaatttgaac tatgagtctc ctgcatggca     2160

acaaaatgtg tgtcaccatc aggccaacag gccagccctt gaatggggat ttattactgt     2220

tgtatctatg ttgcatgata aacattcatc accttcctcc tgtagtcctg cctcgtactc     2280

cccttcccct atgattgaaa agtaaacaaa acccacattt cctatcctgg ttagaagaaa     2340

attaatgttc tgacagttgt gatcgcctgg agtactttta gacttttagc attcgttttt     2400

tacctgtttg tggatgtgtg tttgtatgtg catacgtatg agataggcac atgcatcttc     2460

tgtatggaca aaggtggggt acctacagga gagcaaaggt taattttgtg cttttagtaa     2520

aaacatttaa atacaaagtt ctttattggg tggaattata tttgatgcaa atatttgatc     2580

acttaaaact tttaaaactt ctaggtaatt tgccacgctt tttgactgct caccaatacc     2640

ctgtaaaaat acgtaattct tcctgtttgt gtaataagat attcatattt gtagttgcat     2700

taataatagt tatttcttag tccatcagat gttcccgtgt gcctctttta tgccaaattg     2760

attgtcatat ttcatgttgg gaccaagtag tttgcccatg gcaaacctaa atttatgacc     2820

tgctgaggcc tctcagaaaa ctgagcatac tagcaagaca gctcttcttg aaaaaaaaaa     2880

tatgtataca caaatatata cgtatatcta tatatacgta tgtatataca cacatgtata     2940

ttcttccttg attgtgtagc tgtccaaaat aataacatat atagagggag ctgtattcct     3000

ttatacaaat ctgatggctc ctgcagcact ttttccttct gaaaatattt acattttgct     3060

aacctagttt gttactttaa aaatcagttt tgatgaaagg agggaaaagc agatggactt     3120

gaaaaagatc caagctccta ttagaaaagg tatgaaaatc tttatagtaa aattttttat     3180

aaactaaagt tgtacctttt aatatgtagt aaactctcat ttatttgggg ttcgctcttg     3240

gatctcatcc atccattgtg ttctctttaa tgctgcctgc cttttgaggc attcactgcc     3300

ctagacaatg ccaccagaga tagtggggga aatgccagat gaaaccaact cttgctctca     3360

ctagttgtca gcttctctgg ataagtgacc acagaagcag gagtcctcct gcttgggcat     3420

cattgggcca gttccttctc tttaaatcag atttgtaatg gctcccaaat tccatcacat     3480

cacatttaaa ttgcagacag tgttttgcac atcatgtatc tgttttgtcc cataatatgc     3540

tttttactcc ctgatcccag tttctgctgt tgactcttcc attcagtttt atttattgtg     3600

tgttctcaca gtgacaccat ttgtcctttt ctgcaacaac ctttccagct acttttgcca     3660

aattctattt gtcttctcct tcaaaacatt ctcctttgca gttcctcttc atctgtgtag     3720

ctgctctttt gtctcttaac ttaccattcc tatagtactt tatgcatctc tgcttagttc     3780

tattagtttt ttggccttgc tcttctcctt gattttaaaa ttccttctat agctagagct     3840

tttctttctt tcattctctc ttcctgcagt gttttgcata catcagaagc taggtacata     3900

agttaaatga ttgagagttg gctgtattta gatttatcac tttttaatag ggtgagcttg     3960

agagttttct ttctttctgt tttttttttt tgtttttttt tttttttttt tttttttttt     4020

ttttgactaa tttcacatgc tctaaaaacc ttcaaaggtg attatttttc tcctggaaac     4080

tccaggtcca ttctgtttaa atccctaaga atgtcagaat taaaataaca gggctatccc     4140

gtaattggaa atatttcttt tttcaggatg ctatagtcaa tttagtaagt gaccaccaaa     4200

ttgttatttg cactaacaaa gctcaaaaca cgataagttt actcctccat ctcagtaata     4260

aaaattaagc tgtaatcaac cttctaggtt tctcttgtct taaaatgggt attcaaaaat     4320

ggggatctgt ggtgtatgta tggaaacaca tactccttaa tttacctgtt gttggaaact     4380

ggagaaatga ttgtcgggca accgtttatt ttttattgta ttttatttgg ttgagggatt     4440

tttttataaa cagttttact tgtgtcatat tttaaaatta ctaactgcca tcacctgctg     4500

gggtcctttg ttaggtcatt ttcagtgact aatagggata atccaggtaa ctttgaagag     4560

atgagcagtg agtgaccagg cagtttttct gcctttagct ttgacagttc ttaattaaga     4620

tcattgaaga ccagctttct cataaatttc tctttttgaa aaaaagaaag catttgtact     4680

aagctcctct gtaagacaac atcttaaatc ttaaaagtgt tgttatcatg actggtgaga     4740

gaagaaaaca ttttgttttt attaaatgga gcattattta caaaaagcca ttgttgagaa     4800

ttagatccca catcgtataa atatctatta accattctaa ataaagagaa ctccagtgtt     4860

gctatgtgca agatcctctc ttggagcttt tttgcatagc aattaaaggt gtgctatttg     4920

tcagtagcca tttttttgca gtgatttgaa gaccaaagtt gttttacagc tgtgttaccg     4980

ttaaaggttt ttttttttat atgtattaaa tcaatttatc actgtttaaa gctttgaata     5040

tctgcaatct ttgccaaggt acttttttat ttaaaaaaaa acataacttt gtaaatatta     5100

ccctgtaata ttatatatac ttaataaaac attttaagct attttgttgg gctatttcta     5160

ttgctgctac agcagaccac aagcacattt ctgaaaaatt taatttatta atgtattttt     5220

aagttgctta tattctaggt aacaatgtaa agaatgattt aaaatattaa ttatgaattt     5280

tttgagtata atacccaata agcttttaat tagagcagag ttttaattaa aagttttaaa     5340

tcagtc                                                                5346


<210>  3
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Heavy Chain Variable Region (With Leader Sequence)

<400>  3

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Val Ser Ile 
        35                  40                  45              


Arg Ser Ile Asn Trp Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr 
        115                 120                 125             


Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  4
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Light Chain Variable Region (With Leader Sequence)

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Val Ser Ile Arg Ser Ile 
            20                  25                  30          


Asn Trp Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  5
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Light  Chain Variable Region (With Leader Sequence)

<400>  5

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Gly Ala Phe Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asp Trp Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125     


<210>  6
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Light Chain Variable Region (Without Leader Sequence)

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Phe Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Trp Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Heavy Chain CDR1

<400>  7

Ser Ile Asn Trp Trp Asn 
1               5       


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Heavy Chain CDR2

<400>  8

Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Heavy Chain CDR3

<400>  9

Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15      


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Light Chain CDR1

<400>  10

Arg Ala Ser Glu Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Light Chain CDR2

<400>  11

Gly Ala Phe Asn Arg Ala Thr 
1               5           


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Light Chain CDR3

<400>  12

Gln Gln Arg Ser Asp Trp Phe Thr 
1               5               


<210>  13
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Heavy Chain (With Leader Sequence)

<400>  13

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Val Ser Ile 
        35                  40                  45              


Arg Ser Ile Asn Trp Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr 
        115                 120                 125             


Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Glu Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Gly Thr Ala 
145                 150                 155                 160 


Leu Lys Ser Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Ser Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Gly Leu Tyr Thr Leu 
        195                 200                 205             


Thr Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val 
    210                 215                 220                 


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Ile Val Pro Arg Asn Cys Gly Gly Asp Cys Lys Pro Cys Ile Cys Thr 
                245                 250                 255     


Gly Ser Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Ile Ser Gln Asp Asp Pro Glu Val His Phe Ser Trp Phe Val Asp Asp 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Arg Pro Pro Glu Glu Gln Phe Asn 
305                 310                 315                 320 


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Arg Thr Phe Arg Cys Lys Val Thr Ser Ala Ala Phe Pro 
            340                 345                 350         


Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Glu Gly Arg Thr Gln Val 
        355                 360                 365             


Pro His Val Tyr Thr Met Ser Pro Thr Lys Glu Glu Met Thr Gln Asn 
    370                 375                 380                 


Glu Val Ser Ile Thr Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Gln Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Pro Pro Thr Met Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Asn Val Lys Lys Glu Lys Trp Gln Gln Gly Asn Thr Phe Thr Cys 
        435                 440                 445             


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly 
465                 


<210>  14
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Light Chain (With Leader Sequence)

<400>  14

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Gly Ala Phe Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asp Trp Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Thr Glu Gln Leu 
    130                 135                 140                 


Ala Thr Gly Gly Ala Ser Val Val Cys Leu Met Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Asp Ile Ser Val Lys Trp Lys Ile Asp Gly Thr Glu Arg Arg Asp 
                165                 170                 175     


Gly Val Leu Asp Ser Val Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Ser Leu Thr Lys Ala Asp Tyr Glu Ser His 
        195                 200                 205             


Asn Leu Tyr Thr Cys Glu Val Val His Lys Thr Ser Ser Ser Pro Val 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  15
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Heavy Chain (Without Leader Sequence)

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Val Ser Ile Arg Ser Ile 
            20                  25                  30          


Asn Trp Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Glu Thr 
        115                 120                 125             


Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Gly Thr Ala Leu Lys Ser 
    130                 135                 140                 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Ser Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Gly Leu Tyr Thr Leu Thr Ser Ser 
            180                 185                 190         


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
    210                 215                 220                 


Arg Asn Cys Gly Gly Asp Cys Lys Pro Cys Ile Cys Thr Gly Ser Glu 
225                 230                 235                 240 


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
                245                 250                 255     


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Gln 
            260                 265                 270         


Asp Asp Pro Glu Val His Phe Ser Trp Phe Val Asp Asp Val Glu Val 
        275                 280                 285             


His Thr Ala Gln Thr Arg Pro Pro Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Ser Val Ser Glu Leu Pro Ile Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Arg Thr Phe Arg Cys Lys Val Thr Ser Ala Ala Phe Pro Ser Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Pro Glu Gly Arg Thr Gln Val Pro His Val 
            340                 345                 350         


Tyr Thr Met Ser Pro Thr Lys Glu Glu Met Thr Gln Asn Glu Val Ser 
        355                 360                 365             


Ile Thr Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile Tyr Val Glu 
    370                 375                 380                 


Trp Gln Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn Thr Pro Pro 
385                 390                 395                 400 


Thr Met Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Asn Val 
                405                 410                 415     


Lys Lys Glu Lys Trp Gln Gln Gly Asn Thr Phe Thr Cys Ser Val Leu 
            420                 425                 430         


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  16
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Light Chain (Without Leader Sequence)

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Phe Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Trp Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Thr Glu Gln Leu Ala Thr Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Leu Met Asn Asn Phe Tyr Pro Arg Asp Ile Ser 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Thr Glu Arg Arg Asp Gly Val Leu Asp 
145                 150                 155                 160 


Ser Val Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Ser Leu Thr Lys Ala Asp Tyr Glu Ser His Asn Leu Tyr Thr 
            180                 185                 190         


Cys Glu Val Val His Lys Thr Ser Ser Ser Pro Val Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  17
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  18
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  19
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  20
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  21
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated IgG4 Constant Region (S228P/L235E)

<400>  21

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  22
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  22

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  23
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 IgG1 Heavy Chain (Without Leader Sequence)

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Val Ser Ile Arg Ser Ile 
            20                  25                  30          


Asn Trp Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  24
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 IgG4 Heavy Chain (Without Leader Sequence)

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Val Ser Ile Arg Ser Ile 
            20                  25                  30          


Asn Trp Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly Lys 
    450         


<210>  25
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 IgG4mt Heavy Chain (Without Leader Sequence)

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Val Ser Ile Arg Ser Ile 
            20                  25                  30          


Asn Trp Trp Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Ile Ala Val Thr Asp Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly Lys 
    450         


<210>  26
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2.3D11 Kappa Light Chain

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Phe Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asp Trp Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  27
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB6.12-IgG4PE Heavy Chain Variable Region

<400>  27

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Thr Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Asp Gln Gly Asp Thr Glu Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Arg Asp Arg Ser Met Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Ala Tyr Gly Ser Ser Ser Tyr Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val 
        115             


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB6.12-IgG4PE Light Chain Variable Region

<400>  28

Asn Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Arg Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys His Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  29
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F9G4 Heavy Chain Variable Region

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F9G4 Light Chain Variable Region

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Gly Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  31
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   B6H12 Heavy Chain Variable Region

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Asp Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B6H12 Light Chain Variable Region

<400>  32

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Gly Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
                405                 410                 415     


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
            420                 425                 430         


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
        435                 440                 445             


Gly Thr Cys Tyr 
    450         


<210>  34
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys 
            100                 105 


<210>  35
<211>  1465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2.3D11 IgG1 Heavy Chain

<400>  35
aagcttaccg ccaccatggg ttggtcctgc atcatcctgt tcctggtggc cacggccacc       60

ggcgtgcact cccaagtcca actccaggag tccggccccg ggctggtcaa gccgtccggc      120

acactgtccc tgacgtgcgc cgtctccggg gtctctatcc ggagcatcaa ctggtggaat      180

tgggtgcggc agccgcccgg taagggcctc gagtggattg gcgagatcta ccactcaggc      240

agcaccaact acaacccctc cctcaagtcg cgcgtcacga tctcggtcga caagtccaag      300

aaccagttct cgctcaagct caacagcgtg accgcggcgg acaccgccgt gtactactgt      360

gcccgggacg gcggcatcgc agtcactgac tactactatt acggcctcga cgtgtggggc      420

caggggacga cggtcacggt gagctccgcc tccaccaaag gccccagcgt cttccccctc      480

gcgccgtcct ccaagtccac ctcgggtggc accgccgccc tgggctgcct ggtcaaggac      540

tacttcccgg agcctgtgac cgtgtcctgg aactcgggcg cgctcacgag cggcgtacac      600

accttcccgg cggtgctcca gtcctccggg ctgtactcgc tctcgtcggt cgtcacggtg      660

ccgtcctcct ccctgggcac ccagacctac atctgcaacg tgaaccacaa gccgtccaac      720

accaaggtgg ataagaaggt cgagcccaag tcgtgcgaca agacgcacac gtgcccgccg      780

tgcccggccc cggagctgct gggcggcccc tcggtcttcc tgttcccccc gaagcccaag      840

gatacgctga tgatctcccg caccccggag gtcacctgcg tggtggtgga cgtctcccac      900

gaggacccgg aggtgaaatt caactggtac gtcgacggag tggaggtcca caacgccaag      960

accaagcccc gggaggagca gtacaactcc acgtaccgcg tcgtctccgt cctgaccgtc     1020

ctccaccagg actggctgaa cggcaaggag tacaagtgta aggtctccaa caaggcgctg     1080

cccgccccca tcgagaagac catctccaag gcaaagggtc agccgcggga gccgcaggtc     1140

tataccctcc ccccgtcccg cgacgagctg acgaaaaacc aggtctccct gacctgcctg     1200

gtgaagggtt tctacccctc cgacatcgcg gtcgagtggg agtcgaacgg ccagccggag     1260

aacaactaca agaccacccc ccccgtgctc gacagtgacg gctcgttctt cctgtactcg     1320

aagctgaccg tcgacaagtc gcgctggcag cagggcaacg tcttctcgtg ctccgttatg     1380

cacgaggccc tgcacaacca ctacacgcag aagagtcttt cgctgtcccc ggggaagtga     1440

taatctagag tcggggcggc cggcc                                           1465


<210>  36
<211>  1456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2.3D11 IgG4 Heavy Chain

<400>  36
aagcttaccg ccaccatggg gtggtcgtgc atcatcctct tcctggtcgc caccgcgacc       60

ggcgtgcatt cgcaggtcca gctccaggag agcggcccgg gcctggtgaa gccctccggc      120

acgctctctc tgacgtgcgc cgtctcggga gtgagtatcc gctcgatcaa ctggtggaac      180

tgggtgcggc agccgccggg caagggcctg gaatggatcg gggagatcta ccactccggg      240

tcgaccaact acaacccgag cctgaagtcc cgggtcacga tcagcgtgga caagtccaag      300

aaccagttct ccctgaagct gaacagtgta acggcggcgg acacggcggt ctactactgt      360

gcgcgcgacg gcggcatcgc cgtgaccgat tactactact acggcctcga cgtatggggc      420

cagggcacca ccgtcacggt gtcgagcgca tcgacgaagg gcccctccgt gttcccccta      480

gccccgtgct cccgcagcac ctctgagtcc acggcggcct tgggctgcct cgtgaaggac      540

tacttcccgg agccggtcac tgtgtcgtgg aactccggcg cgctgaccag cggggtccac      600

accttccccg ccgtcctgca gtcgtcgggc ctgtactccc tgagctcggt ggtgaccgtc      660

ccctccagct ccctcggcac taagacctat acctgcaacg tcgaccacaa gccgtccaac      720

accaaggtgg acaagcgagt ggaatcgaag tacggcccgc cctgcccctc ctgccccgcc      780

cccgagttcc tggggggccc gagcgtcttc ctgttcccgc cgaagccgaa ggacacgctg      840

atgatcagcc ggacgccgga agtgacgtgc gtcgtcgtgg acgtgtccca ggaagaccct      900

gaggtgcagt tcaactggta cgtggacggc gtggaggtgc acaacgcgaa aaccaagccg      960

cgcgaggagc agttcaacag cacctaccgc gtcgtgagcg tcctgacggt gctgcaccag     1020

gactggctca acggcaagga gtacaagtgc aaggtatcca acaagggact gccgtcgtcc     1080

atcgagaaga ccatctccaa ggccaagggc cagccccggg agccccaagt ctacaccctc     1140

cccccgtcgc aggaggagat gacgaagaac caggtctccc tgacctgtct cgtcaagggc     1200

ttctacccct ccgacatcgc cgtcgagtgg gagtccaacg ggcagcccga gaacaactac     1260

aagaccaccc cgccagtcct ggacagtgac gggtcgttct tcctgtactc ccgactcact     1320

gtggacaaga gccgctggca agaggggaac gtcttctcct gctcagtgat gcacgaggcc     1380

ctccacaacc actacaccca aaagtcgctg tccctgtccc tcgggaaatg ataatctaga     1440

gtcggggcgg ccggcc                                                     1456


<210>  37
<211>  1456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2.3D11 IgG4mt Heavy Chain

<400>  37
aagcttaccg ccaccatggg gtggtcgtgc atcatcctct tcctggtcgc caccgcgacc       60

ggcgtgcatt cgcaggtcca gctccaggag agcggcccgg gcctggtgaa gccctccggc      120

acgctctctc tgacgtgcgc cgtctcggga gtgagtatcc gctcgatcaa ctggtggaac      180

tgggtgcggc agccgccggg caagggcctg gaatggatcg gggagatcta ccactccggg      240

tcgaccaact acaacccgag cctgaagtcc cgggtcacga tcagcgtgga caagtccaag      300

aaccagttct ccctgaagct gaacagtgta acggcggcgg acacggcggt ctactactgt      360

gcgcgcgacg gcggcatcgc cgtgaccgat tactactact acggcctcga cgtatggggc      420

cagggcacca ccgtcacggt gtcgagcgca tcgacgaagg gcccctccgt gttcccccta      480

gccccgtgct cccgcagcac ctctgagtcc acggcggcct tgggctgcct cgtgaaggac      540

tacttcccgg agccggtcac tgtgtcgtgg aactccggcg cgctgaccag cggggtccac      600

accttccccg ccgtcctgca gtcgtcgggc ctgtactccc tgagctcggt ggtgaccgtc      660

ccctccagct ccctcggcac taagacctat acctgcaacg tcgaccacaa gccgtccaac      720

accaaggtgg acaagcgagt ggaatcgaag tacggcccgc cctgcccccc ctgccccgcc      780

cccgagttcg agggcgggcc gagcgtcttc ctgttcccgc cgaagccgaa ggacacgctg      840

atgatcagcc ggacgccgga agtgacgtgc gtcgtcgtgg acgtgtccca ggaagaccct      900

gaggtgcagt tcaactggta cgtggacggc gtggaggtgc acaacgcgaa aaccaagccg      960

cgcgaggagc agttcaacag cacctaccgc gtcgtgagcg tcctgacggt gctgcaccag     1020

gactggctca acggcaagga gtacaagtgc aaggtatcca acaagggact gccgtcgtcc     1080

atcgagaaga ccatctccaa ggccaagggc cagccccggg agccccaagt ctacaccctc     1140

cccccgtcgc aggaggagat gacgaagaac caggtctccc tgacctgtct cgtcaagggc     1200

ttctacccct ccgacatcgc cgtcgagtgg gagtccaacg ggcagcccga gaacaactac     1260

aagaccaccc cgccagtcct ggacagtgac gggtcgttct tcctgtactc ccgactcact     1320

gtggacaaga gccgctggca agaggggaac gtcttctcct gctcagtgat gcacgaggcc     1380

ctccacaacc actacaccca aaagtcgctg tccctgtccc tcgggaaatg ataatctaga     1440

gtcggggcgg ccggcc                                                     1456


<210>  38
<211>  736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2.3D11 Kappa Light Chain

<400>  38
aagcttaccg ccaccatggg gtggtcgtgc atcatcctct tcctggtggc caccgccacg       60

ggcgtccact ccgagatcgt cctgacccag tcccccgcca ccctctccct gtcgccgggc      120

gagcgggcca cgctgtcgtg ccgggcgtcc gagtcggtct cgtcgaacct cgcctggtat      180

cagcagaagc ccggccaggc gccgcgcctc ctcatctacg gcgccttcaa tcgcgccacg      240

ggcatccccg cccggttctc cggctccgga tcggggaccg acttcaccct caccatctcc      300

tcgctggagc cggaggactt cgccgtctac tactgccagc aacggtcgga ctggttcacc      360

ttcggaggcg gcaccaaggt cgagatcaag acggtggccg cgccgagcgt cttcatcttc      420

ccgccttccg acgagcagct caagtccggg accgcctccg tagtatgcct cctcaataac      480

ttctaccccc gggaggcgaa ggtccagtgg aaggtcgaca acgccctcca atcgggcaac      540

tcccaggagt cggtgaccga gcaggattcc aaggactcga cctacagtct aagctccacc      600

ctcacactgt cgaaggcgga ctacgagaag cacaaggtgt acgcctgcga ggtcacccac      660

cagggcctga gcagcccggt caccaagtcc ttcaaccggg gcgagtgctg ataatctaga      720

gtcggggcgg ccggcc                                                      736


