                         SEQUENCE LISTING

<110>  Oregon Health & Science University
 
<120>  Design and Characterization of Influenza Vaccines

<130>  076273-003010PC-1024207

<150>  62/221,336
<151>  2015-09-21

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Leu Gly 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Lys Ile Cys Asn Asn Pro His Arg Ile Leu Asp Gly Ile Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Glu Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Gly Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Asn Ala Cys Lys Arg Gly Pro Asp 
145                 150                 155                 160 


Ser Gly Phe Phe Ser Arg Leu Asn Trp Leu Tyr Lys Ser Gly Ser Thr 
                165                 170                 175     


Tyr Pro Val Leu Asn Val Thr Met Pro Asn Asn Asp Asn Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Gln Glu Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Val Ile Asn Ser Asn Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Met Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Thr Cys Ile Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  2
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Asn Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Glu Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Gly Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Ser Gly Gly Ser Tyr Ala Cys Lys Arg Gly Ser Asp 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Tyr Glu Ser Glu Ser Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Gly Asn Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Lys Glu Gln Thr 
        195                 200                 205             


Asn Leu Tyr Val Arg Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Thr Cys Ser Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile Thr 
                565         


<210>  3
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Glu Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Gly Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Ser Gly Gly Ser Tyr Ala Cys Lys Arg Gly Ser Val 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Tyr Lys Ser Glu Ser Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Gly Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Lys Glu Gln Thr 
        195                 200                 205             


Asn Leu Tyr Val Arg Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Thr Cys Ser Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  4
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Glu Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Asp Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Ala Gln Ser Gly Gly Ser Tyr Ala Cys Lys Arg Gly Ser Val 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu His Glu Ser Glu Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Gly Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Arg Glu Gln Thr 
        195                 200                 205             


Asn Leu Tyr Val Arg Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Thr Cys Ser Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  5
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Asp Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Ala Gln Asp Gly Lys Ser Tyr Ala Cys Lys Arg Gly Ser Val 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu His Lys Leu Glu Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Asp Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Asn Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Asn Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  6
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Ala Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Ile 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu His Gln Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Val Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  7
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  8
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  9
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Ser Ala Cys Lys Arg Gly Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Glu Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  10
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  11
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Gly Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  12
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Ser Ala Cys Lys Arg Gly Ser Asp 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu His Glu Leu Glu Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Lys Asp Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  13
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Ser Ala Cys Lys Arg Gly Ser Val 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Gln Asp Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Thr Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  14
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Tyr Ala Cys Lys Arg Gly Ser Val 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu His Lys Ser Glu Ser Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Gln Glu Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Thr Cys Ser Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  15
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
aagcttatga agaccatcat cgccctctcc tatatctttt gcctggtgtt cgcccagaac       60

ctgcccggca acgacaatag cacagccaca ctctgtctcg gacaccatgc cgtgcccaac      120

ggcacactgg tgaagacaat tacaaatgac cagatcgagg tgaccaatgc caccgaactg      180

gtgcagagca gctccaccgg aaggatttgc gactcccctc acagaatcct ggacggcaag      240

aattgtaccc tgatcgacgc cctgctggga gatcctcatt gtgacggctt ccagaacgaa      300

aagtgggacc tgttcgtgga gaggtccaag gctttcagca attgctaccc ctacgacgtc      360

cctgattacg ccagcctgag gagcctggtg gccagcagcg gcacactgga attcatcaac      420

gaaggcttca actggaccgg agtgacccag tccggaggct cctacgcctg caagagggga      480

agcgacaaca gcttcttcag cagactcaac tggctgtacg agtccgaaag caagtacccc      540

gccctgaacg tgaccatgcc caataacggc aacttcgaca aactgtacat ctggggcgtc      600

catcacccca gcaccgacaa ggagcaaaca aacctctacg tgagggcttc cggaagggtc      660

accgtgtcca ccaagagaag ccagcagacc gtgatcccca atattggcag caggccctgg      720

gtgagaggcc tgagcagcag gatcagcatc tactggacca tcgtcaagcc cggcgacatc      780

ctgctcatta actccacagg caacctcatc gcccctagag gctacttcaa gatcaggacc      840

ggcaagtcct ccatcatgag gagcgatgcc cctatcggca cctgtagcag cgagtgcatt      900

acccccaacg gctccatccc taacgacaag cctttccaga acgtcaacaa gattacatac      960

ggcgcctgtc ccaagtacgt gaagcagaac accctgaagc tggccaccgg aatgaggaac     1020

gtgcccgaga agcagacaag gggcattttc ggcgccatcg ccggcttcat tgaaaacgga     1080

tgggagggca tggtggatgg ctggtatggc tttagacacc agaatagcga gggcacaggc     1140

caggccgccg acctcaaaag cacccaggcc gccatcgacc agatcaatgg caagctgaac     1200

aggctgatcg agaagacaaa tgagaagttt caccagatcg agaaggagtt cagcgaagtg     1260

gagggcagga ttcaggatct cgaaaagtac gtggaggaca ccaaaatcga cctctggtcc     1320

tacaatgccg agctgctggt ggccctcgag aatcagcata ccatcgacct gacagatagc     1380

gagatgaata agctgtttga gaagaccaga aaacagctga gggagaatgc cgaagacatg     1440

ggaaatggct gcttcaaaat ctatcacaag tgcgataatg cctgcatcgg cagcatcagg     1500

aacggcacct acgaccacga cgtgtacagg gacgaggccc tcaataatag gttccagatc     1560

aagggcgtgg agctgaagtc cggatacaag gactggatac tgtggatttc cttcgccatc     1620

agctgttttc tgctgtgcgt cgtgctgctg ggattcatca tgtgggcctg ccagaaggga     1680

aatatcagat gtaacatctg catctgatag ggatcc                               1716


<210>  16
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
aagcttatga agaccatcat cgccctgtcc tacatcttct gcctggtgtt cgcccaaaag       60

ctgcctggca acgataactc cacagccacc ctgtgtctgg gacaccacgc tgtgcctaac      120

ggaaccctgg tcaagaccat caccaacgac cagatcgagg tgaccaacgc caccgagctg      180

gtccaaagca gctccaccgg cagaatttgc gacagccccc acagaatcct ggacggaaag      240

aattgcaccc tgatcgacgc cctcctggga gatccccatt gcgacggctt ccagaacgaa      300

gagtgggacc tgtttgtgga aagaagcaag gcctactcca actgctaccc ttacgacgtc      360

cctgattacg cctccctgag atccctggtg gcctcctccg gcaccctgga gttcattaac      420

gaggatttta attggaccgg cgtggcccag agcggaggca gctatgcctg taagagagga      480

agcgtgaaca gcttcttctc caggctgaac tggctccacg agagcgaata caagtacccc      540

gccctgaacg tgacaatgcc caacaacggc aagtttgata agctgtacat ctggggcgtc      600

catcacccct ccacagacag ggagcaaacc aatctgtacg tgagggcttc cggaagagtg      660

accgtgtcca ccaagaggtc ccagcagacc gtgatcccca acatcgggag caggccctgg      720

gtgagaggcc tctccagcag aatcagcatc tactggacca tcgtcaagcc cggagacatc      780

ctgctgatca acagcaccgg caacctgatc gcccctagag gctatttcaa gatcaggacc      840

ggcaagagca gcatcatgag gagcgacgct cccatcggca cctgctcctc cgagtgtatc      900

acacccaacg gcagcatccc taacgacaag cctttccaga acgtcaacaa gatcacctac      960

ggcgcctgcc ctagatacgt gaagcagaac accctgaagc tggccaccgg aatgaggaac     1020

gtgcccgaaa agcagaccag gggaattttc ggcgccattg ccggattcat cgagaacgga     1080

tgggagggaa tggtggacgg ctggtacggc tttaggcacc agaactccga gggcacaggc     1140

caagccgccg acctcaaatc cacccaggcc gccatcgacc agatcaacgg caagctgaac     1200

agactgatcg aaaagaccaa cgagaagttc caccagatcg agaaggaatt ctccgaggtg     1260

gagggaagaa tccaggacct cgagaagtac gtggaagaca ccaagatcga cctgtggagc     1320

tacaacgccg aactcctcgt ggctctggag aatcagcaca ccattgacct gaccgacagc     1380

gagatgaaca agctgttcga gaaaaccagg aagcagctga gagagaacgc cgaggatatg     1440

ggaaatggct gtttcaagat ctaccataaa tgcgacaacg cctgcatcgg aagcatcagg     1500

aacggcacct acgaccacga cgtctacagg gacgaagccc tgaataatag gttccagatc     1560

aaaggcgtgg agctcaagag cggctataag gactggatac tgtggatttc cttcgccatc     1620

agctgtttcc tgctgtgcgt ggtcctgctg ggattcatca tgtgggcctg ccagaaggga     1680

aacatcaggt gcaacatctg tatctaatag ggatcc                               1716


<210>  17
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
aagcttatga agaccatcat tgccctgtcc tacatcctgt gcctggtctt tgcccagaag       60

ctgcccggca acgacaactc cacagccacc ctgtgtctgg gccaccatgc cgtgcccaac      120

ggaaccctcg tgaagaccat taccaacgac cagatcgagg tgaccaatgc caccgagctg      180

gtccagagca gcagcaccgg cagaatctgc gacagccccc accaaatcct ggatggcgaa      240

aattgcaccc tgatcgatgc cctcctgggc gacccccact gtgatggctt ccagaacaag      300

gagtgggacc tcttcgtgga aaggagcaag gcttactcca actgctaccc ctatgacgtg      360

cccgactacg cctccctgag gtccctcgtc gccagcagcg gaaccctcga attcaacaac      420

gagagcttca actggaccgg agtcgcccag aatggcacca gcagcgcctg taagaggagg      480

tccatcaaga gcttcttcag caggctgaac tggctccacc agctgaagta taaatacccc      540

gccctgaacg tcaccatgcc caacaatgag aagttcgaca agctgtacat ttggggagtg      600

catcacccta gcaccgatag cgaccaaatc tccctgtatg cccaggccag cggcagagtg      660

acagtgtcca caaagaggag ccagcagacc gtcattccca atattggcag cagaccttgg      720

gtgagaggcg tcagctccag gatctccatt tattggacca tcgtgaagcc tggcgacatc      780

ctcctcatca actccacagg caatctgatc gctcccaggg gctattttaa gattaggtcc      840

ggcaagagca gcatcatgag gagcgacgcc cctatcggca agtgcaacag cgagtgtatc      900

acccccaacg gcagcattcc caacgacaaa cccttccaga acgtgaacag gatcacctac      960

ggcgcctgcc ctagatacgt gaagcagaac accctgaagc tggccaccgg aatgaggaac     1020

gtgcccgaaa agcagaccag gggaattttc ggcgccattg ccggattcat cgagaacgga     1080

tgggagggaa tggtggacgg ctggtacggc tttaggcacc agaactccga gggcacaggc     1140

caagccgccg acctcaaatc cacccaggcc gccatcaatc agattaacgg caaactgaat     1200

aggctgattg aaaaaacaaa cgagaaattc catcagattg agaaagagtt cagcgaggtg     1260

gaaggcagaa tacaggacct ggagaagtac gtggaagaca ccaagatcga cctctggtcc     1320

tacaatgctg agctgctggt cgccctggag aatcagcaca ccatcgacct caccgacagc     1380

gagatgaata agctcttcga gaggaccaag aagcagctga gagagaacgc cgaggacatg     1440

ggcaatggct gcttcaagat ctatcacaag tgcgacaacg cctgtatcgg cagcatcaga     1500

aacggcacat acgatcacga cgtgtacagg gacgaggctc tcaacaacag gttccaaatt     1560

aagggcgtcg agctcaagag cggctacaag gactggatac tgtggattag cttcgccatc     1620

agctgctttc tgctgtgtgt ggtgctcctc ggcttcatca tgtgggcctg ccagaagggc     1680

aatatcaggt gcaacatttg catttaatag ggatcc                               1716


<210>  18
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
aagcttatga agaccatcat tgccctgtcc tacatcctgt gcctggtctt tgcccagaag       60

ctgcccggca acgacaactc cacagccacc ctgtgtctgg gccaccatgc cgtgcccaac      120

ggaaccctcg tgaagaccat taccaacgac cagatcgagg tgaccaatgc caccgagctg      180

gtccagagca gcagcaccgg cagaatctgc gacagccccc accaaatcct ggatggcgaa      240

aattgcaccc tgatcgatgc cctcctgggc gacccccact gtgatggctt ccagaacaag      300

gagtgggacc tcttcgtgga aaggagcaag gcttactcca actgctaccc ctatgacgtg      360

cccgactacg cctccctgag gtccctcgtc gccagcagcg gaaccctcga attcaacaac      420

gagagcttca actggaccgg agtcgcccag aatggcacca gcagcgcctg taagaggagg      480

tccatcaaga gcttcttcag caggctgaac tggctccacc agctgaagta taaatacccc      540

gccctgaacg tcaccatgcc caacaatgag aagttcgaca agctgtacat ttggggagtg      600

catcacccta gcaccgatag cgaccaaatc tccctgtatg cccaggccag cggcagagtg      660

acagtgtcca caaagaggag ccagcagacc gtcattccca atattggcag cagaccttgg      720

gtgagaggcg tctccagcag gatttccatc tattggacca tcgtgaaacc cggagacatc      780

ctgctgatca acagcaccgg caacctgatt gcccccaggg gctatttcaa gatcaggagc      840

ggcaagtcct ccatcatgag gtccgacgcc cccatcggca agtgtaactc cgaatgcatc      900

acccccaacg gctccatccc taacgacaag cccttccaga acgtcaacag gatcacctat      960

ggcgcctgcc ccaggtacgt gaaacagaac accctgaaac tcgccacagg catgaggaat     1020

gtgcccgaga aacagacaag gggcatcttc ggcgccatcg ccggatttat tgagaatggc     1080

tgggaaggca tggtggatgg ctggtacggc ttcaggcatc agaattccga gggcaccgga     1140

caagccgccg acctcaagtc cacccaggcc gccatcaatc agattaacgg caaactgaat     1200

aggctgattg aaaaaacaaa cgagaaattc catcagattg agaaagagtt cagcgaggtg     1260

gaaggcagaa tacaggacct ggagaagtac gtggaagaca ccaagatcga cctctggtcc     1320

tacaatgctg agctgctggt cgccctggag aatcagcaca ccatcgacct caccgacagc     1380

gagatgaata agctcttcga gaggaccaag aagcagctga gagagaacgc cgaggacatg     1440

ggcaatggct gcttcaagat ctatcacaag tgcgacaacg cctgtatcgg cagcatcaga     1500

aacggcacat acgatcacga cgtgtacagg gacgaggctc tcaacaacag gttccaaatt     1560

aagggcgtcg agctcaagag cggctacaag gactggatac tgtggattag cttcgccatc     1620

agctgctttc tgctgtgtgt ggtgctcctc ggcttcatca tgtgggcctg ccagaagggc     1680

aatatcaggt gcaacatttg catttgatag ggatcc                               1716


<210>  19
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
aagcttatga agaccattat cgccctgtcc tatatcctgt gcctggtgtt tgcccagaaa       60

ctgcccggca acgacaactc caccgccaca ctctgtctgg gacaccacgc cgtgcccaac      120

ggcaccatcg tcaaaaccat caccaacgac cagattgagg tcacaaatgc caccgaactg      180

gtgcagagca gcagcaccgg cgagatttgc gactcccctc atcagatcct ggacggcgaa      240

aactgtaccc tgatcgacgc tctcctcggc gaccctcagt gtgacggatt ccagaacaaa      300

aagtgggacc tcttcgtgga gaggtccaag gcttacagca actgctaccc ttacgacgtc      360

cctgactacg cctccctgag gagcctggtc gctagctccg gcaccctgga gttcaacaac      420

gagagcttca actggacagg cgtgacccag aacggcacaa gcagcgcctg caagagaagg      480

agcaacaatt ccttcttttc caggctcaat tggctgaccc acctgaagtt caagtaccct      540

gccctcaacg tcaccatgcc caataatgag aagtttgata agctgtatat ctggggagtg      600

caccaccccg gcacagataa cgaccagatc tttctgtacg ctcaggcctc cggaagaatc      660

accgtgagca ccaagagaag ccagcaaacc gtgatcccca acattggctc cagacctagg      720

gtcaggaaca tccctagcag gatcagcatc tattggacca tcgtgaagcc tggcgacatc      780

ctcctgatca actccacagg caacctgatc gcccctaggg gctacttcaa aatcaggagc      840

ggcaaaagca gcatcatgag gagcgatgcc cccatcggaa agtgtaacag cgagtgcatc      900

acccccaacg gctccatccc caacgataaa cccttccaga acgtcaacag gattacctac      960

ggcgcctgtc ccagatacgt gaagcagaac accctgaaac tcgccaccgg catgaggaat     1020

gtccctgaga agcagaccag aggaatcttc ggagccattg ccggctttat cgagaacggc     1080

tgggagggca tggtggatgg ctggtacgga ttcaggcatc agaacagcga gggaattgga     1140

caggccgctg acctcaagtc cacacaggct gccatcaacc agatcaatgg caagctcaac     1200

aggctgatcg gcaagaccaa tgaaaagttt caccagattg agaaggaatt cagcgaggtc     1260

gaaggcagaa tacaggacct ggagaagtac gtggaggaca ccaagatcga cctctggtcc     1320

tataatgccg agctgctggt cgccctggag aatcagcaca caatcgacct gaccgacagc     1380

gagatgaaca aactgttcga aaggaccaaa aagcagctca gggagaacgc cgaggacatg     1440

ggcaatggct gcttcaagat ttatcacaag tgtgacaatg cctgtatcgg gagcatcagg     1500

aacggcacct acgaccacga cgtgtatagg gacgaggccc tgaacaacag gttccagatc     1560

aaaggcgtcg agctgaagtc cggatacaag gactggatac tgtggatcag ctttgccatc     1620

tcctgctttc tgctctgcgt ggccctgctc ggcttcatca tgtgggcctg tcagaagggc     1680

aatatcagat gcaacatctg catctgatag ggatcc                               1716


<210>  20
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
aagcttatga aaaccatcat cgccctgagc tatatcctct gtctggtgtt cgcccagaag       60

ctgcccggca atgacaactc caccgccaca ctctgtctcg gccatcacgc cgtgcccaac      120

ggcacaatcg tgaagaccat taccaatgat cagatcgagg tgaccaatgc caccgaactg      180

gtgcaaagca gcagcaccgg cgagatctgc gacagccctc accagattct ggatggcgag      240

aactgcacac tcatcgatgc cctgctgggc gaccctcagt gtgacggctt ccagaacaag      300

aagtgggatc tgttcgtgga gagatccaag gcctacagca actgctaccc ttacgacgtg      360

cctgactacg cctccctgag gtccctggtc gcctcctccg gaacactgga gttcaacaac      420

gagagcttta actggaccgg cgtgacacag aacggcacaa gcagcgcctg caagaggagg      480

agcaacaact ccttcttcag caggctgaac tggctgaccc acctgaaatt caagtacccc      540

gctctgaacg tcacaatgcc caataacgag aagtttgaca agctgtacat ttggggagtg      600

catcaccccg gaaccgacaa ggaccagatc ttcctgtatg cccaggcctc cggcaggatt      660

accgtctcca ccaagaggag ccagcagaca gtgatcccca acatcggcag cagacctagg      720

gtcaggaaca tccccagcag gatctccatc tactggacaa ttgtcaagcc cggcgacatc      780

ctcctcatca acagcaccgg caacctcatt gcccctagag gctacttcaa gatcagatcc      840

ggcaagagca gcatcatgag atccgacgcc cccatcggca agtgtaactc cgagtgcatt      900

acccccaatg gctccattcc caacgacaaa cccttccaga atgtgaacag gatcacatat      960

ggcgcctgcc ccagatacgt gaagcagaac accctcaagc tggctaccgg catgaggaac     1020

gtgcccgaaa agcagacaag gggcatcttc ggcgctatcg ctggcttcat cgaaaacgga     1080

tgggaaggca tggtcgatgg ctggtacggc ttcaggcatc agaactccga aggcagggga     1140

caagctgccg acctgaagag cacacaggct gccatcaatc agattaacgg caaactgaac     1200

aggctgatcg gcaaaacaaa tgaaaagttc caccagatcg agaaggaatt cagcgaagtc     1260

gaaggcagaa tacaggacct ggagaaatac gtggaggaca caaagatcga cctgtggtcc     1320

tataacgctg agctcctggt ggctctggag aaccaacaca caatcgacct gaccgatagc     1380

gagatgaaca agctgttcga gaggaccaag aagcagctga gagagaatgc cgaggacatg     1440

ggcaatggct gctttaaaat ttaccacaaa tgcgacaacg cctgcattgg ctccatcagg     1500

aacggcacct atgaccacga cgtgtacagg gacgaggccc tcaacaacag gttccagatc     1560

aagggagtcg agctgaagag cggctacaag gactggatac tgtggatcag ctttgccatc     1620

tcctgtttcc tcctgtgcgt cgctctgctg ggcttcatta tgtgggcctg ccagaaaggc     1680

aacattaggt gtaacatctg tatttaatag ggatcc                               1716


<210>  21
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
aagcttatga agaccatcat cgctctcagc tacattctgt gcctcgtgtt tgctcagaag       60

ctgcccggca acgataacag caccgccacc ctgtgcctcg gccatcatgc cgtccccaat      120

ggcaccatcg tcaagacaat caccaacgac cagatcgagg tcaccaacgc caccgaactg      180

gtgcaaagct ccagcaccgg cagaatctgc gactcccccc accagatcct ggatggagag      240

aactgcaccc tgatcgatgc tctgctggga gacccccact gcgacggctt ccagaataag      300

aagtgggacc tgttcgtgga aagatccaag gcctactcca actgctaccc ttacgacgtg      360

cccgactacg cctccctgag gtccctggtc gcttcctccg gcaccctgga gttcatcaat      420

gagtccttca actggaccgg cgtcacccaa aacggcggca gcagcgcttg taaaaggggc      480

agcaataact ccttcttcag caggctgaac tggctgaccc atctggagta caagtacccc      540

gccctgaatg tgaccatgcc caacaacgag aagttcgata agctctatat ctggggcgtg      600

caccaccccg gaacagacaa ggatcagatc agcctgtacg ctcaggcctc cggaaggatt      660

acagtctcca ccaagaggag ccagcagaca gtcatcccca acatcggcag caggcccagg      720

gtgagaggcc tgagctccag gatctccatt tattggacca tcgtgaagcc tggcgacatc      780

ctcctcatca actccacagg caatctgatc gctcccaggg gctattttaa gattaggtcc      840

ggcaagagca gcatcatgag gagcgacgcc cctatcggca agtgcaacag cgagtgtatc      900

acccccaacg gcagcattcc caacgacaaa cccttccaga acgtgaacag gatcacctac      960

ggcgcctgcc ctagatacgt gaagcagaac accctgaagc tggccaccgg aatgaggaac     1020

gtgcccgaaa agcagaccag gggaattttc ggcgccattg ccggattcat cgagaacgga     1080

tgggagggaa tggtggacgg ctggtacggc tttaggcacc agaactccga gggcacaggc     1140

caagccgccg acctcaaatc cacccaggcc gccatcgacc agatcaacgg caagctgaac     1200

agactgatcg aaaagaccaa cgagaagttc caccagatcg agaaggaatt ctccgaggtg     1260

gagggaagaa tccaggacct cgagaagtac gtggaagaca ccaagatcga cctgtggagc     1320

tacaacgccg aactcctcgt ggctctggag aatcagcaca ccattgacct gaccgacagc     1380

gagatgaaca agctgttcga gaaaaccaag aaacagctga gagaaaacgc cgaggacatg     1440

ggcaatggat gcttcaagat ttaccataag tgcgacaacg cttgtatcgg gagcatcagg     1500

aatggcacct acgatcatga cgtgtacagg gacgaggccc tgaacaacag gttccagatc     1560

aaaggcgtgg agctcaaatc cggctataag gattggatac tgtggatctc cttcgctatc     1620

tcctgcttcc tgctgtgcgt cgccctgctg ggcttcatca tgtgggcctg ccagaaggga     1680

aacatcagat gtaacatctg tatttaatag ggatcc                               1716


<210>  22
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
aagcttatga aaacaatcat cgccctctcc tatatcctgt gcctggtgtt cgctcaaaag       60

ctccccggca acgacaacag caccgctaca ctgtgtctgg gccaccacgc cgtccccaac      120

ggaaccatcg tgaagaccat caccaacgac caaatcgagg tgaccaacgc caccgagctc      180

gtgcagtcca gcagcaccgg cgagatttgc gatagccctc atcagatcct ggacggcgag      240

aactgcaccc tgatcgacgc tctgctgggc gacccccagt gtgacggatt tcagaacaag      300

aaatgggacc tcttcgtgga gaggtccaag gcctactcca actgctaccc ctacgacgtc      360

cccgattacg cctccctgag gagcctggtg gctagctccg gcaccctcga attcaacaac      420

gagtccttca actggacagg cgtcacccag aatggaacct cctccgcctg catcaggaga      480

tccaataaca gcttcttcag caggctgaat tggctcacac acctgaactt caagtacccc      540

gccctcaacg tgaccatgcc caacaacgag cagttcgaca agctctacat ctggggcgtc      600

catcaccctg gcaccgacaa ggatcaaatc ttcctctacg cccaggcctc cggcagaatc      660

accgtcagca ccaagaggtc ccagcagaca gtcatcccca acatcggctc caggcccagg      720

gtgaggaaca tccccagcag aatctccatc tactggacca tcgtgaaacc cggagacatt      780

ctcctgatta acagcaccgg caacctgatc gcccctaggg gctactttaa gatcaggtcc      840

ggaaaaagca gcatcatgag gtccgacgct cccatcggca agtgcaactc cgagtgcatt      900

acacccaatg gcagcatccc taacgacaag cctttccaga atgtgaacag gatcacatac      960

ggcgcctgcc ctaggtatgt gaaacagaac accctgaagc tggccaccgg catgaggaat     1020

gtgcctgaga agcagaccag gggcattttc ggcgccattg ctggcttcat cgagaacggc     1080

tgggagggaa tggtggacgg ctggtacggc ttcagacacc agaatagcga aggcagggga     1140

caggccgccg acctgaaaag cacccaggcc gccatcgatc agattaacgg aaagctgaac     1200

agactgatcg gaaagacaaa cgaaaagttt caccagatcg agaaggagtt cagcgaggtg     1260

gaaggcagga ttcaagacct ggagaagtac gtcgaagaca ccaagatcga cctgtggagc     1320

tacaatgccg agctgctcgt ggctctcgag aaccagcaca ccatcgacct gaccgactcc     1380

gagatgaaca agctgttcga gaagaccaag aagcagctga gggagaacgc cgaagatatg     1440

ggaaacggct gctttaagat ctatcacaag tgtgacaacg cctgcatcgg cagcatcagg     1500

aacggcacat acgatcacga tgtgtacaga gacgaggctc tcaacaacag gttccagatc     1560

aagggcgtgg agctcaagtc cggatacaag gactggatac tgtggattag cttcgccatc     1620

tcctgctttc tcctgtgtgt ggccctgctg ggctttatca tgtgggcctg ccagaagggc     1680

aatatcagat gcaacatctg catctgatag ggatcc                               1716


<210>  23
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
aagcttatga aaacaatcat cgccctctcc tatatcctgt gcctggtgtt cgctcaaaag       60

ctccccggca acgacaacag caccgctaca ctgtgtctgg gccaccacgc cgtccccaac      120

ggaaccatcg tgaagaccat caccaacgac caaatcgagg tgaccaacgc caccgagctc      180

gtgcagtcca gcagcaccgg cgagatttgc gatagccctc atcagatcct ggacggcgag      240

aactgcaccc tgatcgacgc tctgctgggc gacccccagt gtgacggatt tcagaacaag      300

aaatgggacc tcttcgtgga gaggtccaag gcctactcca actgctaccc ctacgacgtc      360

cccgattacg cctccctgag gagcctggtg gctagctccg gcaccctcga attcaacaac      420

gagtccttca actggacagg cgtcacccag aatggaacct cctccgcctg catcaggggc      480

tccaataaca gcttcttcag caggctgaat tggctcacac acctgaactt caagtacccc      540

gccctcaacg tgaccatgcc caacaacgag cagttcgaca agctctacat ctggggcgtc      600

catcaccctg gcaccgacaa ggatcaaatc ttcctctacg cccaggcctc cggcagaatc      660

accgtcagca ccaagaggtc ccagcaggcc gtcatcccca acatcggctc caggcccagg      720

atcaggaaca tccccagcag aatctccatc tactggacca tcgtgaaacc cggagacatt      780

ctcctgatta acagcaccgg caacctgatc gcccctaggg gctactttaa gatcaggtcc      840

ggaaaaagca gcatcatgag gtccgacgct cccatcggca agtgcaactc cgagtgcatt      900

acacccaatg gcagcatccc taacgacaag cctttccaga atgtgaacag gatcacatac      960

ggcgcctgcc ctaggtatgt gaaacagagc accctgaagc tggccaccgg catgaggaat     1020

gtgcctgaga agcagaccag gggcattttc ggcgccattg ctggcttcat cgagaacggc     1080

tgggagggaa tggtggacgg ctggtacggc ttcagacacc agaatagcga aggcagggga     1140

caggccgccg acctgaaaag cacccaggcc gccatcgatc agattaacgg aaagctgaac     1200

agactgatcg gaaagacaaa cgaaaagttt caccagatcg agaaggagtt cagcgaggtg     1260

gaaggcagga ttcaagacct ggagaagtac gtcgaagaca ccaagatcga cctgtggagc     1320

tacaatgccg agctgctcgt ggctctcgag aaccagcaca ccatcgacct gaccgactcc     1380

gagatgaaca agctgttcga gaagaccaag aagcagctga gggagaacgc cgaagatatg     1440

ggaaacggct gctttaagat ctatcacaag tgtgacaacg cctgcatcgg cagcatcagg     1500

aacggcacat acgatcacga tgtgtacaga gacgaggctc tcaacaacag gttccagatc     1560

aagggcgtgg agctcaagtc cggatacaag gactggatac tgtggattag cttcgccatc     1620

tcctgctttc tcctgtgtgt ggccctgctg ggctttatca tgtgggcctg ccagaagggc     1680

aatatcagat gcaacatctg catctgatag ggatcc                               1716


<210>  24
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
aagcttatga agaccatcat tgccctctcc tacatcctgt gtctcgtgtt cgcccagaag       60

ctgcccggca acgacaattc caccgccaca ctctgcctgg gacaccacgc cgtgcccaat      120

ggcaccctgg tgaagacaat cacaaacgat cagatcgagg tgaccaatgc cacagagctg      180

gtgcagtcca gcagcacagg aaggatctgc gacagccctc acagaatcct ggacggcgaa      240

aactgcaccc tgatcgacgc cctgctgggc gatcctcact gtgacggctt ccagaacaag      300

aagtgggacc tcttcgtgga gagatccaag gcctactcca actgttaccc ttacgacgtg      360

cccgactatg ctagcctgag atccctggtg gctagcagcg gcacactgga gttcattaac      420

gagagcttca actggaccgg cgtgacccaa aatggcggca gctccgcctg caagagaggc      480

agcgacaata gcttcttcag cagactgaac tggctgcacg agctggagta caagtacccc      540

gctctgaacg tgaccatgcc taataatgag aaattcgata aactgtacat ttggggcgtg      600

caccacccct ccaccgacaa ggatcagacc agcctgtatg tgcaggcctc cggcagagtg      660

acagtgtcca ccaagaggag ccaacagacc gtgattccca atatcggcag cagaccctgg      720

gtcaggggac tcagcagcag gatcagcatc tactggacaa ttgtcaagcc cggcgatatc      780

ctgctgatca acagcacagg caacctgatc gcccctaggg gctatttcaa gatcaggtcc      840

ggcaagagca gcatcatgag atccgacgct cccatcggca agtgcaactc cgaatgcatt      900

acccccaacg gcagcatccc caatgacaag cccttccaga acgtcaacag aatcacctac      960

ggcgcttgcc ctaggtacgt gaaacagaac accctcaaac tcgccaccgg catgaggaac     1020

gtgcctgaga agcagaccag gggcattttt ggcgctatcg ctggcttcat cgagaatgga     1080

tgggagggca tggtggacgg ctggtatggc ttcaggcacc agaatagcga gggaacagga     1140

caggccgccg acctgaaatc cacacaggcc gccatcgacc agatcaatgg caaactcaat     1200

aggctcatcg aaaagaccaa cgagaagttt catcagatcg agaaggagtt ctccgaggtg     1260

gaaggaagaa tccaggacct ggagaagtac gtggaggaca ccaagatcga cctgtggagc     1320

tacaacgccg agctgctggt ggctctggag aaccagcaca ccattgatct gaccgatagc     1380

gagatgaaca agctgttcga gaaaaccaga aagcagctca gggagaacgc cgaggacatg     1440

ggcaacggat gtttcaagat ctaccacaag tgcgacaacg cctgtatcgg cagcattagg     1500

aacggcacct acgaccacga tgtgtatagg gacgaggccc tgaacaacag atttcaaatc     1560

aagggcgtcg aactcaagtc cggctacaag gactggatac tgtggatctc cttcgccatc     1620

tcctgcttcc tcctgtgcgt ggtgctgctc ggcttcatca tgtgggcttg ccagaagggc     1680

aacatcaggt gcaacatctg tatctgatag ggatcc                               1716


<210>  25
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25
aagcttatga aaaccatcat cgctctgtcc tacatcttct gtctcgtgtt cgcccagaag       60

ctgcccggaa acgataacag caccgctacc ctgtgcctgg gacaccatgc tgtgcccaac      120

ggaaccctcg tgaagacaat caccaatgac cagatcgaag tcaccaacgc caccgagctg      180

gtccagtcca gctccaccgg cagaatttgc gactcccccc acagaattct ggacggcaaa      240

aactgcaccc tgatcgacgc tctcctgggc gacccccatt gcgacggctt ccaaaacgaa      300

gagtgggacc tgttcgtgga gaggtccaaa gccttcagca actgctatcc ctacgacgtg      360

cctgattacg cctccctcag aagcctggtc gcctcctccg gcacactgga gttcatcaac      420

gaaggcttca actggaccgg cgtggctcag aatggcggca gctccgcttg caaaaggggc      480

tccgtcaaca gcttcttcag caggctgaac tggctccata aactggaatc caagtaccct      540

gccctgaacg tgaccatgcc caacaatggc aagttcgaca agctgtacat ctggggagtg      600

caccacccca gcaccgacaa ggaccagaca aatctgtacg tgcaggcttc cggaagagtg      660

accgtgtcca ccaagaggtc ccagcagacc gtgatcccca acatcgggag caggccctgg      720

gtgagaggcc tctccagcag aatcagcatc tactggacca tcgtcaagcc cggagacatc      780

ctgctgatca acagcaccgg caacctgatc gcccctagag gctatttcaa gatcaggacc      840

ggcaagagca gcatcatgag gagcgacgct cccatcggca cctgctcctc cgagtgtatc      900

acacccaacg gcagcatccc taacgacaag cctttccaga acgtcaacaa gatcacctac      960

ggcgcctgcc ctagatacgt gaagcagaac accctgaagc tggccaccgg aatgaggaac     1020

gtgcccgaaa agcagaccag gggaattttc ggcgccattg ccggattcat cgagaacgga     1080

tgggagggaa tggtggacgg ctggtacggc tttaggcacc agaactccga gggcacaggc     1140

caagccgccg acctcaaatc cacccaggcc gccatcgacc agatcaacgg caagctgaac     1200

agactgatcg aaaagaccaa cgagaagttc caccagatcg agaaggaatt ctccgaggtg     1260

gagggaagaa tccaggacct cgagaagtac gtggaagaca ccaagatcga cctgtggagc     1320

tacaacgccg aactcctcgt ggctctggag aatcagcaca ccattgacct gaccgacagc     1380

gagatgaaca agctgttcga gaaaaccagg aagcagctga gagagaacgc cgaggatatg     1440

ggaaatggct gtttcaagat ctaccataaa tgcgacaacg cctgcatcgg aagcatcagg     1500

aacggcacct acgaccacga cgtctacagg gacgaagccc tgaataatag gttccagatc     1560

aaaggcgtgg agctcaagag cggctataag gactggatac tgtggatttc cttcgccatc     1620

agctgtttcc tgctgtgcgt ggtcctgctg ggattcatca tgtgggcctg ccagaaggga     1680

aacatcaggt gcaacatctg tatctaatag ggatcc                               1716


<210>  26
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
aagcttatga aaaccatcat tgccctctcc tacatctttt gcctggtgtt tgcccagaag       60

ctccctggca acgacaacag caccgccaca ctgtgcctgg gacaccatgc tgtgcccaat      120

ggaaccctcg tgaagaccat caccaatgac cagatcgagg tgaccaatgc cacagaactg      180

gtgcagagct ccagcaccgg caggatctgt gatagccccc acagaatcct ggacggcaaa      240

aactgcacac tgatcgacgc tctcctggga gacccccact gtgacggctt tcagaacaag      300

gagtgggatc tgtttgtcga gagatccaag gcttactcca attgctaccc ttacgacgtg      360

cccgactatg ccagcctcag gagcctggtg gccagctccg gaaccctgga gttcatcaac      420

gagggcttta attggaccgg cgtgacccaa aatggcggct cctccgcctg taagaggggc      480

tccgtgaact ccttcttcag caggctgaat tggctgcaca agctggagtc caagtatccc      540

gccctgaacg tcaccatgcc caacaacgac aagtttgata aactctacat ctggggagtg      600

caccacccca gcacagacaa ggaccagaca agcctgtacg tccaggcttc cggaagggtg      660

accgtgtcca ccaagaggag ccagcagacc gtgatcccta atatcggcag caggccctgg      720

gtcagaggcc tgtccagcag gatcagcatc tactggacca ttgtgaagcc cggagacatc      780

ctcctgatta actccaccgg caacctgatc gctcccaggg gctactttaa aattaggacc      840

ggaaagagca gcatcatgag gtccgacgcc cctatcggca catgcaactc cgagtgcatt      900

acccccaacg gaagcattcc caatgacaag ccttttcaga acgtcaacag gatcacctac      960

ggcgcctgcc ctagatacgt gaagcagaac accctgaagc tggccaccgg aatgaggaac     1020

gtgcccgaaa agcagaccag gggaattttc ggcgccattg ccggattcat cgagaacgga     1080

tgggagggaa tggtggacgg ctggtacggc tttaggcacc agaactccga gggcacaggc     1140

caagccgccg acctcaaatc cacccaggcc gccatcgacc agatcaacgg caagctgaac     1200

agactgatcg aaaagaccaa cgagaagttc caccagatcg agaaggaatt ctccgaggtg     1260

gagggaagaa tccaggacct cgagaagtac gtggaagaca ccaagatcga cctgtggagc     1320

tacaacgccg aactcctcgt ggctctggag aatcagcaca ccattgacct gaccgacagc     1380

gagatgaaca agctgttcga gaaaaccagg aagcagctga gagagaacgc cgaggatatg     1440

ggaaatggct gtttcaagat ctaccataaa tgcgacaacg cctgcatcgg aagcatcagg     1500

aacggcacct acgaccacga cgtctacagg gacgaagccc tgaataatag gttccagatc     1560

aaaggcgtgg agctcaagag cggctataag gactggatac tgtggatttc cttcgccatc     1620

agctgtttcc tgctgtgcgt ggtcctgctg ggattcatca tgtgggcctg ccagaaggga     1680

aacatcaggt gcaacatctg tatctaatag ggatcc                               1716


<210>  27
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Met Asn Pro Asn Lys Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Thr Gly Met Val Ser Leu Met Leu Gln Ile Gly Asn Leu Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile His Thr Gly Asn Gln His Lys Ala Glu Pro 
        35                  40                  45              


Ile Ser Asn Thr Asn Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys 
    50                  55                  60                  


Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Asn Gly Trp Ala Val Tyr 
65                  70                  75                  80  


Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
                85                  90                  95      


Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg Thr Phe 
            100                 105                 110         


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
        115                 120                 125             


Val Lys Asp Arg Ser Pro His Arg Thr Leu Met Ser Cys Pro Val Gly 
    130                 135                 140                 


Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
145                 150                 155                 160 


Ala Ser Ala Cys His Asp Gly Thr Ser Trp Leu Thr Ile Gly Ile Ser 
                165                 170                 175     


Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
            180                 185                 190         


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
        195                 200                 205             


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Val Met Thr Asp 
    210                 215                 220                 


Gly Pro Ser Asn Gly Gln Ala Ser His Lys Ile Phe Lys Met Glu Lys 
225                 230                 235                 240 


Gly Lys Val Val Lys Ser Val Glu Leu Asp Ala Pro Asn Tyr His Tyr 
                245                 250                 255     


Glu Glu Cys Ser Cys Tyr Pro Asp Ala Gly Glu Ile Thr Cys Val Cys 
            260                 265                 270         


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
        275                 280                 285             


Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
    290                 295                 300                 


Asn Pro Arg Pro Asn Asp Gly Thr Gly Ser Cys Gly Pro Val Ser Ser 
305                 310                 315                 320 


Asn Gly Ala Tyr Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
                325                 330                 335     


Val Trp Ile Gly Arg Thr Lys Ser Thr Asn Ser Arg Ser Gly Phe Glu 
            340                 345                 350         


Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Ser Phe Ser 
        355                 360                 365             


Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser Gly Tyr Ser Gly 
    370                 375                 380                 


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
385                 390                 395                 400 


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Ser Thr Ile 
                405                 410                 415     


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
            420                 425                 430         


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
        435                 440                 445             


Lys 
    


<210>  28
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
atgaatccta ataagaagat catcacaatc ggaagcatct gcatggtgac aggaatggtg       60

agcctgatgc tgcagatcgg aaatctgatc agcatctggg tgagccacag catccacaca      120

ggaaatcagc acaaggccga gcctatcagc aatacaaatt ttctgacaga gaaggccgtg      180

gccagcgtga agctggccgg aaatagcagc ctgtgcccta tcaatggatg ggccgtgtac      240

agcaaggata atagcatcag aatcggaagc aagggagatg tgtttgtgat cagagagcct      300

tttatcagct gcagccacct ggagtgcaga acattttttc tgacacaggg agccctgctg      360

aatgataagc acagcaatgg aacagtgaag gatagaagcc ctcacagaac actgatgagc      420

tgccctgtgg gagaggcccc tagcccttac aatagcagat ttgagagcgt ggcctggagc      480

gccagcgcct gccacgatgg aacaagctgg ctgacaatcg gaatcagcgg acctgataat      540

ggagccgtgg ccgtgctgaa gtacaatgga atcatcacag atacaatcaa gagctggaga      600

aataatatcc tgagaacaca ggagagcgag tgcgcctgcg tgaatggaag ctgctttaca      660

gtgatgacag atggacctag caatggacag gccagccaca agatctttaa gatggagaag      720

ggaaaggtgg tgaagagcgt ggagctggat gcccctaatt accactacga ggagtgcagc      780

tgctaccctg atgccggaga gatcacatgc gtgtgcagag ataattggca cggaagcaat      840

agaccttggg tgagctttaa tcagaatctg gagtaccaga tcggatacat ctgcagcgga      900

gtgtttggag ataatcctag acctaatgat ggaacaggaa gctgcggacc tgtgagcagc      960

aatggagcct acggagtgaa gggatttagc tttaagtacg gaaatggagt gtggatcgga     1020

agaacaaaga gcacaaatag cagaagcgga tttgagatga tctgggaccc taatggatgg     1080

acagagacag atagcagctt tagcgtgaag caggatatcg tggccatcac agattggagc     1140

ggatacagcg gaagctttgt gcagcaccct gagctgacag gactggattg catcagacct     1200

tgcttttggg tggagctgat cagaggaaga cctaaggaga gcacaatctg gacaagcgga     1260

agcagcatca gcttttgcgg agtgaatagc gatacagtgg gatggagctg gcctgatgga     1320

gccgagctgc cttttacaat cgataagtga                                      1350


<210>  29
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 
65                  70                  75                  80  


Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala 
                85                  90                  95      


Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe 
    130                 135                 140                 


Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Ser Gln 
        195                 200                 205             


Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His Pro Ser 
    210                 215                 220                 


Ser Ser Ala Gly Leu Lys Asn Asp Leu Leu Glu Asn Leu Gln Ala Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  30
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
atgagcctgc tgaccgaggt ggagacatac gtgctgtcca tcatccccag cggccctctg       60

aaggccgaga tcgcccagag actggaagat gtgttcgccg gcaagaacac cgacctggaa      120

gtgctgatgg aatggctgaa aaccagaccc atcctgagcc ctctgaccaa gggcatcctg      180

ggcttcgtgt tcaccctgac cgtgcccagc gagagaggcc tgcagaggcg gagattcgtg      240

cagaacgccc tgaacggcaa cggcgacccc aacaacatgg acaaggccgt gaagctgtac      300

agaaagctga agcgggagat caccttccac ggcgccaaag agatcagcct gagctacagc      360

gctggcgccc tggccagctg catgggcctg atctacaaca gaatgggcgc cgtgaccacc      420

gaggtggcct tcggcctggt ctgcgccacc tgcgagcaga tcgccgacag ccagcacaga      480

tcccacagac agatggtcac caccaccaac cccctgatca gacacgagaa cagaatggtg      540

ctggcctcta ccaccgccaa ggccatggaa cagatggccg gcagcagcga gcaggccgcc      600

gaggctatgg aagtcgcctc tcaggctagg cagatggtcc aggccatgag aaccatcggc      660

acccacccca gcagctctgc tggcctgaag aacgacctgc tggaaaacct gcaggcctac      720

cagaaaagaa tgggcgtcca gatgcagaga ttcaagtga                             759


