
                                SEQUENCE LISTING

<110> Qiagen Sciences LLC
      Biopeptides Corp.
      Gundersen Lutheran Medical Foundation, Inc.
      Callister, Steven M.
      Boyle, Jeff
      Miyamasu, Misato
      Dattwyler, Raymond J.
      Arnaboldi, Paul M.

<120> COMPOSITIONS AND METHODS FOR DIAGNOSING
  LYME DISEASE AND FOR PREDICTING LYME DISEASE SPIROCHETE
  ELIMINATION AFTER TREATMENT
  

<130> 770025.466WO

<140> PCT                 
<141> 2016-09-15  

<150> US 62/233,192       
<151> 2015-09-25  

<160> 40

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 1
Asn Val Arg Thr Ala Glu Glu Leu Gly Met Gln Pro Ala Lys Ile Asn
 1               5                  10                  15
Thr Pro Ala Ser Leu Ser Gly Ser Gln
            20                  25

<210> 2
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 2
Asn Thr Pro Ala Ser Leu Ser Gly Ser Gln Ala Ser Trp Thr Leu Arg
 1               5                  10                  15
Val His Val Gly
            20

<210> 3
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 3
Leu Ser Gly Ser Gln Ala Ser Trp Thr Leu Arg Val His Val Gly Ala
 1               5                  10                  15
Asn Gln Asp Glu
            20

<210> 4
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 4
Gln Asp Glu Ala Ile Ala Val Asn Ile Tyr Ala Ala Asn Val Ala Asn
 1               5                  10                  15
Leu Phe Ser Gly
            20

<210> 5
<211> 19
<212> PRT
<213> Borrelia sp.


<400> 5
Ser Leu Ala Lys Ile Glu Asn Ala Ile Arg Met Ile Ser Asp Gln Arg
 1               5                  10                  15
Ala Asn Leu


<210> 6
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 6
Ser Ile Val Met Val Leu Phe Phe Asp Leu Leu Val Ala Cys Ser Ile
 1               5                  10                  15
Gly Leu Val Glu
            20

<210> 7
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 7
Leu Phe Phe Asp Leu Leu Val Ala Cys Ser Ile Gly Leu Val Glu Arg
 1               5                  10                  15
Thr Asn Ala Ala
            20

<210> 8
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 8
Ile Gly Leu Val Glu Arg Thr Asn Ala Ala Leu Glu Ser Ser Ser Lys
 1               5                  10                  15
Asp Leu Lys Asn Lys Ile Leu Lys Ile
            20                  25

<210> 9
<211> 25
<212> PRT
<213> Borrelia sp.

<400> 9
Lys Asp Leu Lys Asn Lys Ile Leu Lys Ile Lys Lys Glu Ala Thr Gly
 1               5                  10                  15
Lys Gly Val Leu Phe Glu Ala Phe Thr
            20                  25

<210> 10
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 10
Gly Lys Gly Val Leu Phe Glu Ala Phe Thr Gly Leu Lys Thr Gly Ser
 1               5                  10                  15
Lys Val Thr Ser Gly Gly Leu Ala Leu
            20                  25

<210> 11
<211> 25
<212> PRT
<213> Borrelia sp.

<400> 11
Ser Lys Val Thr Ser Gly Gly Leu Ala Leu Arg Glu Ala Lys Val Gln
 1               5                  10                  15
Ala Ile Val Glu Thr Gly Lys Phe Leu
            20                  25

<210> 12
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 12
Gln Ala Ile Val Glu Thr Gly Lys Phe Leu Lys Ile Ile Glu Glu Glu
 1               5                  10                  15
Ala Leu Lys Leu Lys Glu Thr Gly Asn
            20                  25

<210> 13
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 13
Glu Ala Leu Lys Leu Lys Glu Thr Gly Asn Ser Gly Gln Phe Leu Ala
 1               5                  10                  15
Met Phe Asp Leu Met Leu Glu Val Val
            20                  25

<210> 14
<211> 25
<212> PRT
<213> Borrelia sp.

<400> 14
Ala Met Phe Asp Leu Met Leu Glu Val Val Glu Ser Leu Glu Asp Val
 1               5                  10                  15
Gly Ile Ile Gly Leu Lys Ala Arg Val
            20                  25

<210> 15
<211> 25
<212> PRT
<213> Borrelia sp.

<400> 15
Val Gly Ile Ile Gly Leu Lys Ala Arg Val Leu Glu Glu Ser Lys Asn
 1               5                  10                  15
Asn Pro Ile Asn Thr Ala Glu Arg Leu
            20                  25

<210> 16
<211> 25
<212> PRT
<213> Borrelia sp.

<400> 16
Asn Asn Pro Ile Asn Thr Ala Glu Arg Leu Leu Ala Ala Lys Ala Gln
 1               5                  10                  15
Ile Glu Asn Gln Leu Lys Val Val Lys
            20                  25

<210> 17
<211> 25
<212> PRT
<213> Borrelia sp.

<400> 17
Gln Ile Glu Asn Gln Leu Lys Val Val Lys Glu Lys Gln Asn Ile Glu
 1               5                  10                  15
Asn Gly Gly Glu Lys Lys Asn Asn Lys
            20                  25

<210> 18
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 18
Leu Lys Val Val Lys Glu Lys Gln Asn Ile Glu Asn Gly Gly Glu Lys
 1               5                  10                  15
Lys Asn Asn Lys Ser Lys Lys Lys Lys
            20                  25

<210> 19
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 19
Phe Gly Leu Ser Gly Ala Tyr Gly Asn Glu Thr Phe Asn Asn Ser Ser
 1               5                  10                  15
Ile Thr Tyr Ser Leu Lys Asp Lys Ser
            20                  25

<210> 20
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 20
Ser Ile Thr Tyr Ser Leu Lys Asp Lys Ser Val Val Gly Asn Asp Leu
 1               5                  10                  15
Leu Ser Pro Thr Leu Ser Asn Ser Ala
            20                  25

<210> 21
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 21
Leu Leu Ser Pro Thr Leu Ser Asn Ser Ala Ile Leu Ala Ser Phe Gly
 1               5                  10                  15
Ala Lys Tyr Lys Leu Gly Leu Thr Lys
            20                  25

<210> 22
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 22
Gly Ala Lys Tyr Lys Leu Gly Leu Thr Lys Ile Asn Asp Lys Asn Thr
 1               5                  10                  15
Tyr Leu Ile Leu
            20

<210> 23
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 23
Leu Gly Leu Thr Lys Ile Asn Asp Lys Asn Thr Tyr Leu Ile Leu Gln
 1               5                  10                  15
Met Gly Thr Asp
            20

<210> 24
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 24
Thr Tyr Leu Ile Leu Gln Met Gly Thr Asp Phe Gly Ile Asp Pro Phe
 1               5                  10                  15
Ala Ser Asp Phe
            20

<210> 25
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 25
Gln Met Gly Thr Asp Phe Gly Ile Asp Pro Phe Ala Ser Asp Phe Ser
 1               5                  10                  15
Ile Phe Gly His
            20

<210> 26
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 26
Phe Ala Ser Asp Phe Ser Ile Phe Gly His Ile Ser Lys Ala Ala Asn
 1               5                  10                  15
Phe Lys Lys Glu Thr Pro Ser Asp Pro
            20                  25

<210> 27
<211> 25
<212> PRT
<213> Borrelia sp.

<400> 27
Asn Phe Lys Lys Glu Thr Pro Ser Asp Pro Asn Lys Lys Ala Glu Ile
 1               5                  10                  15
Phe Asp Pro Asn Gly Asn Ala Leu Asn
            20                  25

<210> 28
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 28
Ile Phe Asp Pro Asn Gly Asn Ala Leu Asn Phe Ser Lys Asn Thr Glu
 1               5                  10                  15
Leu Gly Ile Ala Phe Ser Thr Gly Ala
            20                  25

<210> 29
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 29
Glu Leu Gly Ile Ala Phe Ser Thr Gly Ala Ser Ile Gly Phe Ala Trp
 1               5                  10                  15
Asn Lys Asp Thr
            20

<210> 30
<211> 20
<212> PRT
<213> Borrelia sp.


<400> 30
Phe Ser Thr Gly Ala Ser Ile Gly Phe Ala Trp Asn Lys Asp Thr Gly
 1               5                  10                  15
Glu Lys Glu Ser
            20

<210> 31
<211> 25
<212> PRT
<213> Borrelia sp.


<400> 31
Phe Ser Thr Gly Ala Ser Ile Gly Phe Ala Trp Asn Lys Asp Thr Gly
 1               5                  10                  15
Glu Lys Glu Ser Trp Ala Ile Lys Gly
            20                  25

<210> 32
<211> 15
<212> PRT
<213> Borrelia sp.


<400> 32
Lys Glu Met Leu Ala Asn Ser Val Lys Glu Leu Thr Ser Pro Ile
 1               5                  10                  15

<210> 33
<211> 21
<212> PRT
<213> Borrelia sp.


<400> 33
Ala Thr Lys Ala Ile Gly Lys Lys Ile Gln Gln Asn Gly Gly Leu Ala
 1               5                  10                  15
Val Glu Ala Gly His
            20

<210> 34
<211> 40
<212> PRT
<213> Borrelia burgdorferi

<400> 34
Asn Val Arg Thr Ala Glu Glu Leu Gly Met Gln Pro Ala Lys Ile Asn
 1               5                  10                  15
Thr Pro Ala Ser Leu Ser Gly Ser Gln Ala Ser Trp Thr Leu Arg Val
            20                  25                  30
His Val Gly Ala Asn Gln Asp Glu
        35                  40

<210> 35
<211> 20
<212> PRT
<213> Borrelia  burgdorferi

<400> 35
Gln Asp Glu Ala Ile Ala Val Asn Ile Tyr Ala Ala Asn Val Ala Asn
 1               5                  10                  15
Leu Phe Ser Gly
            20

<210> 36
<211> 19
<212> PRT
<213> Borrelia  burgdorferi

<400> 36
Ser Leu Ala Lys Ile Glu Asn Ala Ile Arg Met Ile Ser Asp Gln Arg
 1               5                  10                  15
Ala Asn Leu


<210> 37
<211> 180
<212> PRT
<213> Borrelia burgdorferi

<400> 37
Ser Ile Val Met Val Leu Phe Phe Asp Leu Leu Val Ala Cys Ser Ile
 1               5                  10                  15
Gly Leu Val Glu Arg Thr Asn Ala Ala Leu Glu Ser Ser Ser Lys Asp
            20                  25                  30
Leu Lys Asn Lys Ile Leu Lys Ile Lys Lys Glu Ala Thr Gly Lys Gly
        35                  40                  45
Val Leu Phe Glu Ala Phe Thr Gly Leu Lys Thr Gly Ser Lys Val Thr
    50                  55                  60
Ser Gly Gly Leu Ala Leu Arg Glu Ala Lys Val Gln Ala Ile Val Glu
65                  70                  75                  80
Thr Gly Lys Phe Leu Lys Ile Ile Glu Glu Glu Ala Leu Lys Leu Lys
                85                  90                  95
Glu Thr Gly Asn Ser Gly Gln Phe Leu Ala Met Phe Asp Leu Met Leu
            100                 105                 110
Glu Val Val Glu Ser Leu Glu Asp Val Gly Ile Ile Gly Leu Lys Ala
        115                 120                 125
Arg Val Leu Glu Glu Ser Lys Asn Asn Pro Ile Asn Thr Ala Glu Arg
    130                 135                 140
Leu Leu Ala Ala Lys Ala Gln Ile Glu Asn Gln Leu Lys Val Val Lys
145                 150                 155                 160
Glu Lys Gln Asn Ile Glu Asn Gly Gly Glu Lys Lys Asn Asn Lys Ser
                165                 170                 175
Lys Lys Lys Lys
            180

<210> 38
<211> 150
<212> PRT
<213> Borrelia burgdorferi

<400> 38
Phe Gly Leu Ser Gly Ala Tyr Gly Asn Glu Thr Phe Asn Asn Ser Ser
 1               5                  10                  15
Ile Thr Tyr Ser Leu Lys Asp Lys Ser Val Val Gly Asn Asp Leu Leu
            20                  25                  30
Ser Pro Thr Leu Ser Asn Ser Ala Ile Leu Ala Ser Phe Gly Ala Lys
        35                  40                  45
Tyr Lys Leu Gly Leu Thr Lys Ile Asn Asp Lys Asn Thr Tyr Leu Ile
    50                  55                  60
Leu Gln Met Gly Thr Asp Phe Gly Ile Asp Pro Phe Ala Ser Asp Phe
65                  70                  75                  80
Ser Ile Phe Gly His Ile Ser Lys Ala Ala Asn Phe Lys Lys Glu Thr
                85                  90                  95
Pro Ser Asp Pro Asn Lys Lys Ala Glu Ile Phe Asp Pro Asn Gly Asn
            100                 105                 110
Ala Leu Asn Phe Ser Lys Asn Thr Glu Leu Gly Ile Ala Phe Ser Thr
        115                 120                 125
Gly Ala Ser Ile Gly Phe Ala Trp Asn Lys Asp Thr Gly Glu Lys Glu
    130                 135                 140
Ser Trp Ala Ile Lys Gly
145                 150

<210> 39
<211> 21
<212> PRT
<213> Borrelia burgdorferi

<400> 39
Ala Thr Lys Ala Ile Gly Lys Lys Ile Gln Gln Asn Gly Gly Leu Ala
 1               5                  10                  15
Val Glu Ala Gly His
            20

<210> 40
<211> 15
<212> PRT
<213> Borrelia burgdorferi

<400> 40
Lys Glu Met Leu Ala Asn Ser Val Lys Glu Leu Thr Ser Pro Ile
 1               5                  10                  15
