                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
       Bolt, Gert
       Kjalke, Marianne Hjortns
       Karpf, Ditte Maria
       Rasmussen, Jakob Ewald
       Thim, Lars
 
<120>  FVIII fusion proteins

<130>  150021

<150>  15186246.2
<151>  2015-09-22

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  2332
<212>  PRT
<213>  homo sapiens

<400>  1

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  2
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  2

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn Pro Pro Val Leu 
1               5                   10                  15      


Lys Arg His Gln Arg 
            20      


<210>  3
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  3

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn Pro Pro Val Leu 
1               5                   10                  15      


Lys Arg His Gln 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  synthetic

<400>  4

Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn Pro Pro Val Leu Lys 
1               5                   10                  15      


Arg His Gln Arg 
            20  


<210>  5
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  5

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr 
            20                  25                  


<210>  6
<211>  54
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  6

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu 
    50                  


<210>  7
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  7

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu 
        115         


<210>  8
<211>  163
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  8

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser 
            


<210>  9
<211>  174
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  9

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp 
                165                 170                 


<210>  10
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  10

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn 
    210                 


<210>  11
<211>  226
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  11

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  12
<211>  228
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  12

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu 
225             


<210>  13
<211>  263
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  13

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr 
            260             


<210>  14
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  14

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr 
            260                 265                 


<210>  15
<211>  278
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  15

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro 
        275             


<210>  16
<211>  280
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  16

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu 
        275                 280 


<210>  17
<211>  330
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  17

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser 
                325                 330 


<210>  18
<211>  339
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  18

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln 
            


<210>  19
<211>  466
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  19

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln 
465     


<210>  20
<211>  490
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  20

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu 
                485                 490 


<210>  21
<211>  521
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  21

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr 
        515                 520     


<210>  22
<211>  561
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  22

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr 
    


<210>  23
<211>  569
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln 
                565                 


<210>  24
<211>  646
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  24

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser 
                645     


<210>  25
<211>  655
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  25

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser 
                645                 650                 655 


<210>  26
<211>  704
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  26

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


<210>  27
<211>  700
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  27

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys 
    690                 695                 700 


<210>  28
<211>  721
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  28

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser 
    


<210>  29
<211>  774
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  29

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser 
    770                 


<210>  30
<211>  784
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  30

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser 
    770                 775                 780                 


<210>  31
<211>  813
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  31

Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe Asn 
1               5                   10                  15      


Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp Phe 
            20                  25                  30          


Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser Asp 
        35                  40                  45              


Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser Leu 
    50                  55                  60                  


Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro Ser 
65                  70                  75                  80  


Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His Phe 
                85                  90                  95      


Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu Ser 
            100                 105                 110         


Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala Thr 
        115                 120                 125             


Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn Leu 
    130                 135                 140                 


Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn Thr 
145                 150                 155                 160 


Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln Leu 
                165                 170                 175     


Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser Gly 
            180                 185                 190         


Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu Glu 
        195                 200                 205             


Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val Ser 
    210                 215                 220                 


Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly Pro 
225                 230                 235                 240 


Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser Leu 
                245                 250                 255     


Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys Thr 
            260                 265                 270         


His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val Trp 
        275                 280                 285             


Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro Leu 
    290                 295                 300                 


Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg Leu 
305                 310                 315                 320 


Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met Val 
                325                 330                 335     


Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro Asp 
            340                 345                 350         


Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp Ile 
        355                 360                 365             


Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro Ser 
    370                 375                 380                 


Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly Gln 
385                 390                 395                 400 


Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu Phe 
                405                 410                 415     


Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg Asn 
            420                 425                 430         


Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His Asn 
        435                 440                 445             


Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu Ile 
    450                 455                 460                 


Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr Lys 
465                 470                 475                 480 


Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val Glu 
                485                 490                 495     


Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg Ser 
            500                 505                 510         


Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe Ser 
        515                 520                 525             


Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr Lys 
    530                 535                 540                 


Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn Thr 
545                 550                 555                 560 


Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys Gln 
                565                 570                 575     


Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile Val 
            580                 585                 590         


Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr Pro 
        595                 600                 605             


Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala Ile 
    610                 615                 620                 


Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile Pro 
625                 630                 635                 640 


Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe Pro 
                645                 650                 655     


Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn Ser 
            660                 665                 670         


Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val Gln 
        675                 680                 685             


Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser Leu 
    690                 695                 700                 


Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly Ser 
705                 710                 715                 720 


Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu Asn 
                725                 730                 735     


Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val Glu 
            740                 745                 750         


Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr Glu 
        755                 760                 765             


Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser Leu 
    770                 775                 780                 


Leu Gln Gly Thr Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg Pro 
785                 790                 795                 800 


Gly Lys Val Pro Phe Leu Arg Val Ala Thr Glu Ser Ser 
                805                 810             


<210>  32
<211>  855
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  32

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser 
    770                 775                 780                 


Leu Leu Gln Gly Thr Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg 
785                 790                 795                 800 


Pro Gly Lys Val Pro Phe Leu Arg Val Ala Thr Glu Ser Ser Ala Lys 
                805                 810                 815     


Thr Pro Ser Lys Leu Leu Asp Pro Leu Ala Trp Asp Asn His Tyr Gly 
            820                 825                 830         


Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu 
        835                 840                 845             


Lys Thr Ala Phe Lys Lys Lys 
    850                 855 


<210>  33
<211>  903
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  33

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser 
    770                 775                 780                 


Leu Leu Gln Gly Thr Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg 
785                 790                 795                 800 


Pro Gly Lys Val Pro Phe Leu Arg Val Ala Thr Glu Ser Ser Ala Lys 
                805                 810                 815     


Thr Pro Ser Lys Leu Leu Asp Pro Leu Ala Trp Asp Asn His Tyr Gly 
            820                 825                 830         


Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu 
        835                 840                 845             


Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu Ser Leu Asn Ala Cys 
    850                 855                 860                 


Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu Gly Gln Asn Lys Pro 
865                 870                 875                 880 


Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg Thr Glu Arg Leu Cys 
                885                 890                 895     


Ser Gln Asn Pro Pro Val Leu 
            900             


<210>  34
<211>  908
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  34

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser 
    770                 775                 780                 


Leu Leu Gln Gly Thr Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg 
785                 790                 795                 800 


Pro Gly Lys Val Pro Phe Leu Arg Val Ala Thr Glu Ser Ser Ala Lys 
                805                 810                 815     


Thr Pro Ser Lys Leu Leu Asp Pro Leu Ala Trp Asp Asn His Tyr Gly 
            820                 825                 830         


Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu 
        835                 840                 845             


Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu Ser Leu Asn Ala Cys 
    850                 855                 860                 


Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu Gly Gln Asn Lys Pro 
865                 870                 875                 880 


Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg Thr Glu Arg Leu Cys 
                885                 890                 895     


Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg 
            900                 905             


<210>  35
<211>  585
<212>  PRT
<213>  homo sapiens

<400>  35

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  36
<211>  273
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  36

Gln Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val 
1               5                   10                  15      


Ser Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His 
            20                  25                  30          


Leu Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr 
        35                  40                  45              


Gln Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp 
    50                  55                  60                  


Ser Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro 
65                  70                  75                  80  


Ile Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser 
                85                  90                  95      


Arg Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp 
            100                 105                 110         


Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala 
        115                 120                 125             


Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn 
    130                 135                 140                 


Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg 
145                 150                 155                 160 


Tyr Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala 
                165                 170                 175     


Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu 
            180                 185                 190         


Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu 
        195                 200                 205             


Gln Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg 
    210                 215                 220                 


Asn Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser 
225                 230                 235                 240 


Gly Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys 
                245                 250                 255     


Arg Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr 
            260                 265                 270         


Pro 
    


<210>  37
<211>  227
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  37

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  38
<211>  28
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  38

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  39
<211>  865
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  39

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 
            20                  25                  30          


Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        35                  40                  45              


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
65                  70                  75                  80  


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
                85                  90                  95      


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 
            100                 105                 110         


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
        115                 120                 125             


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    130                 135                 140                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 
145                 150                 155                 160 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 
                165                 170                 175     


Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
        195                 200                 205             


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
    210                 215                 220                 


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
225                 230                 235                 240 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
                245                 250                 255     


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            260                 265                 270         


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
        275                 280                 285             


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
    290                 295                 300                 


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
305                 310                 315                 320 


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
                325                 330                 335     


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
            340                 345                 350         


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
        355                 360                 365             


Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    370                 375                 380                 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
385                 390                 395                 400 


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
                405                 410                 415     


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
            420                 425                 430         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
        435                 440                 445             


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
    450                 455                 460                 


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
465                 470                 475                 480 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
                485                 490                 495     


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            500                 505                 510         


Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        515                 520                 525             


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 
    530                 535                 540                 


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
545                 550                 555                 560 


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                565                 570                 575     


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 
            580                 585                 590         


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
        595                 600                 605             


Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
    610                 615                 620                 


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 
625                 630                 635                 640 


Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 
                645                 650                 655     


Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
            660                 665                 670         


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
        675                 680                 685             


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 
    690                 695                 700                 


Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
705                 710                 715                 720 


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 
                725                 730                 735     


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            740                 745                 750         


Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 
        755                 760                 765             


Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 
    770                 775                 780                 


Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 
785                 790                 795                 800 


Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
                805                 810                 815     


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 
            820                 825                 830         


Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
        835                 840                 845             


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    850                 855                 860                 


Gly 
865 


<210>  40
<211>  2791
<212>  PRT
<213>  homo sapiens

<400>  40

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Val Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu 
            740                 745                 750         


Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys 
        755                 760                 765             


Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser 
    770                 775                 780                 


Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val 
785                 790                 795                 800 


Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro 
                805                 810                 815     


Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg 
            820                 825                 830         


Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile 
        835                 840                 845             


Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro 
    850                 855                 860                 


Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro 
865                 870                 875                 880 


Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser 
                885                 890                 895     


Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile 
            900                 905                 910         


Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu 
        915                 920                 925             


Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu 
    930                 935                 940                 


Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val 
945                 950                 955                 960 


Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn 
                965                 970                 975     


Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val 
            980                 985                 990         


Glu Glu Asp Pro Val Asp Phe Gly  Asn Ser Trp Lys Val  Ser Ser Gln 
        995                 1000                 1005             


Cys Ala  Asp Thr Arg Lys Val  Pro Leu Asp Ser Ser  Pro Ala Thr 
    1010                 1015                 1020             


Cys His  Asn Asn Ile Met Lys  Gln Thr Met Val Asp  Ser Ser Cys 
    1025                 1030                 1035             


Arg Ile  Leu Thr Ser Asp Val  Phe Gln Asp Cys Asn  Lys Leu Val 
    1040                 1045                 1050             


Asp Pro  Glu Pro Tyr Leu Asp  Val Cys Ile Tyr Asp  Thr Cys Ser 
    1055                 1060                 1065             


Cys Glu  Ser Ile Gly Asp Cys  Ala Cys Phe Cys Asp  Thr Ile Ala 
    1070                 1075                 1080             


Ala Tyr  Ala His Val Cys Ala  Gln His Gly Lys Val  Val Thr Trp 
    1085                 1090                 1095             


Arg Thr  Ala Thr Leu Cys Pro  Gln Ser Cys Glu Glu  Arg Asn Leu 
    1100                 1105                 1110             


Arg Glu  Asn Gly Tyr Glu Cys  Glu Trp Arg Tyr Asn  Ser Cys Ala 
    1115                 1120                 1125             


Pro Ala  Cys Gln Val Thr Cys  Gln His Pro Glu Pro  Leu Ala Cys 
    1130                 1135                 1140             


Pro Val  Gln Cys Val Glu Gly  Cys His Ala His Cys  Pro Pro Gly 
    1145                 1150                 1155             


Lys Ile  Leu Asp Glu Leu Leu  Gln Thr Cys Val Asp  Pro Glu Asp 
    1160                 1165                 1170             


Cys Pro  Val Cys Glu Val Ala  Gly Arg Arg Phe Ala  Ser Gly Lys 
    1175                 1180                 1185             


Lys Val  Thr Leu Asn Pro Ser  Asp Pro Glu His Cys  Gln Ile Cys 
    1190                 1195                 1200             


His Cys  Asp Val Val Asn Leu  Thr Cys Glu Ala Cys  Gln Glu Pro 
    1205                 1210                 1215             


Gly Gly  Leu Val Val Pro Pro  Thr Asp Ala Pro Val  Ser Pro Thr 
    1220                 1225                 1230             


Thr Leu  Tyr Val Glu Asp Ile  Ser Glu Pro Pro Leu  His Asp Phe 
    1235                 1240                 1245             


Tyr Cys  Ser Arg Leu Leu Asp  Leu Val Phe Leu Leu  Asp Gly Ser 
    1250                 1255                 1260             


Ser Arg  Leu Ser Glu Ala Glu  Phe Glu Val Leu Lys  Ala Phe Val 
    1265                 1270                 1275             


Val Asp  Met Met Glu Arg Leu  Arg Ile Ser Gln Lys  Trp Val Arg 
    1280                 1285                 1290             


Val Ala  Val Val Glu Tyr His  Asp Gly Ser His Ala  Tyr Ile Gly 
    1295                 1300                 1305             


Leu Lys  Asp Arg Lys Arg Pro  Ser Glu Leu Arg Arg  Ile Ala Ser 
    1310                 1315                 1320             


Gln Val  Lys Tyr Ala Gly Ser  Gln Val Ala Ser Thr  Ser Glu Val 
    1325                 1330                 1335             


Leu Lys  Tyr Thr Leu Phe Gln  Ile Phe Ser Lys Ile  Asp Arg Pro 
    1340                 1345                 1350             


Glu Ala  Ser Arg Ile Ala Leu  Leu Leu Met Ala Ser  Gln Glu Pro 
    1355                 1360                 1365             


Gln Arg  Met Ser Arg Asn Phe  Val Arg Tyr Val Gln  Gly Leu Lys 
    1370                 1375                 1380             


Lys Lys  Lys Val Ile Val Ile  Pro Val Gly Ile Gly  Pro His Ala 
    1385                 1390                 1395             


Asn Leu  Lys Gln Ile Arg Leu  Ile Glu Lys Gln Ala  Pro Glu Asn 
    1400                 1405                 1410             


Lys Ala  Phe Val Leu Ser Ser  Val Asp Glu Leu Glu  Gln Gln Arg 
    1415                 1420                 1425             


Asp Glu  Ile Val Ser Tyr Leu  Cys Asp Leu Ala Pro  Glu Ala Pro 
    1430                 1435                 1440             


Pro Pro  Thr Leu Pro Pro His  Met Ala Gln Val Thr  Val Gly Pro 
    1445                 1450                 1455             


Gly Leu  Leu Gly Val Ser Thr  Leu Gly Pro Lys Arg  Asn Ser Met 
    1460                 1465                 1470             


Val Leu  Asp Val Ala Phe Val  Leu Glu Gly Ser Asp  Lys Ile Gly 
    1475                 1480                 1485             


Glu Ala  Asp Phe Asn Arg Ser  Lys Glu Phe Met Glu  Glu Val Ile 
    1490                 1495                 1500             


Gln Arg  Met Asp Val Gly Gln  Asp Ser Ile His Val  Thr Val Leu 
    1505                 1510                 1515             


Gln Tyr  Ser Tyr Met Val Thr  Val Glu Tyr Pro Phe  Ser Glu Ala 
    1520                 1525                 1530             


Gln Ser  Lys Gly Asp Ile Leu  Gln Arg Val Arg Glu  Ile Arg Tyr 
    1535                 1540                 1545             


Gln Gly  Gly Asn Arg Thr Asn  Thr Gly Leu Ala Leu  Arg Tyr Leu 
    1550                 1555                 1560             


Ser Asp  His Ser Phe Leu Val  Ser Gln Gly Asp Arg  Glu Gln Ala 
    1565                 1570                 1575             


Pro Asn  Leu Val Tyr Met Val  Thr Gly Asn Pro Ala  Ser Asp Glu 
    1580                 1585                 1590             


Ile Lys  Arg Leu Pro Gly Asp  Ile Gln Val Val Pro  Ile Gly Val 
    1595                 1600                 1605             


Gly Pro  Asn Ala Asn Val Gln  Glu Leu Glu Arg Ile  Gly Trp Pro 
    1610                 1615                 1620             


Asn Ala  Pro Ile Leu Ile Gln  Asp Phe Glu Thr Leu  Pro Arg Glu 
    1625                 1630                 1635             


Ala Pro  Asp Leu Val Leu Gln  Arg Cys Cys Ser Gly  Glu Gly Leu 
    1640                 1645                 1650             


Gln Ile  Pro Thr Leu Ser Pro  Ala Pro Asp Cys Ser  Gln Pro Leu 
    1655                 1660                 1665             


Asp Val  Ile Leu Leu Leu Asp  Gly Ser Ser Ser Phe  Pro Ala Ser 
    1670                 1675                 1680             


Tyr Phe  Asp Glu Met Lys Ser  Phe Ala Lys Ala Phe  Ile Ser Lys 
    1685                 1690                 1695             


Ala Asn  Ile Gly Pro Arg Leu  Thr Gln Val Ser Val  Leu Gln Tyr 
    1700                 1705                 1710             


Gly Ser  Ile Thr Thr Ile Asp  Val Pro Trp Asn Val  Val Pro Glu 
    1715                 1720                 1725             


Lys Ala  His Leu Leu Ser Leu  Val Asp Val Met Gln  Arg Glu Gly 
    1730                 1735                 1740             


Gly Pro  Ser Gln Ile Gly Asp  Ala Leu Gly Phe Ala  Val Arg Tyr 
    1745                 1750                 1755             


Leu Thr  Ser Glu Met His Gly  Ala Arg Pro Gly Ala  Ser Lys Ala 
    1760                 1765                 1770             


Val Val  Ile Leu Val Thr Asp  Val Ser Val Asp Ser  Val Asp Ala 
    1775                 1780                 1785             


Ala Ala  Asp Ala Ala Arg Ser  Asn Arg Val Thr Val  Phe Pro Ile 
    1790                 1795                 1800             


Gly Ile  Gly Asp Arg Tyr Asp  Ala Ala Gln Leu Arg  Ile Leu Ala 
    1805                 1810                 1815             


Gly Pro  Ala Gly Asp Ser Asn  Val Val Lys Leu Gln  Arg Ile Glu 
    1820                 1825                 1830             


Asp Leu  Pro Thr Met Val Thr  Leu Gly Asn Ser Phe  Leu His Lys 
    1835                 1840                 1845             


Leu Cys  Ser Gly Phe Val Arg  Ile Cys Met Asp Glu  Asp Gly Asn 
    1850                 1855                 1860             


Glu Lys  Arg Pro Gly Asp Val  Trp Thr Leu Pro Asp  Gln Cys His 
    1865                 1870                 1875             


Thr Val  Thr Cys Gln Pro Asp  Gly Gln Thr Leu Leu  Lys Thr His 
    1880                 1885                 1890             


Arg Val  Asn Cys Asp Arg Gly  Leu Arg Pro Ser Cys  Pro Asn Ser 
    1895                 1900                 1905             


Gln Ser  Pro Val Lys Val Glu  Glu Thr Cys Gly Cys  Arg Trp Thr 
    1910                 1915                 1920             


Cys Pro  Cys Val Cys Thr Gly  Ser Ser Thr Arg His  Ile Val Thr 
    1925                 1930                 1935             


Phe Asp  Gly Gln Asn Phe Lys  Leu Thr Gly Ser Cys  Ser Tyr Val 
    1940                 1945                 1950             


Leu Phe  Gln Asn Lys Glu Gln  Asp Leu Glu Val Ile  Leu His Asn 
    1955                 1960                 1965             


Gly Ala  Cys Ser Pro Gly Ala  Arg Gln Gly Cys Met  Lys Ser Ile 
    1970                 1975                 1980             


Glu Val  Lys His Ser Ala Leu  Ser Val Glu Leu His  Ser Asp Met 
    1985                 1990                 1995             


Glu Val  Thr Val Asn Gly Arg  Leu Val Ser Val Pro  Tyr Val Gly 
    2000                 2005                 2010             


Gly Asn  Met Glu Val Asn Val  Tyr Gly Ala Ile Met  His Glu Val 
    2015                 2020                 2025             


Arg Phe  Asn His Leu Gly His  Ile Phe Thr Phe Thr  Pro Gln Asn 
    2030                 2035                 2040             


Asn Glu  Phe Gln Leu Gln Leu  Ser Pro Lys Thr Phe  Ala Ser Lys 
    2045                 2050                 2055             


Thr Tyr  Gly Leu Cys Gly Ile  Cys Asp Glu Asn Gly  Ala Asn Asp 
    2060                 2065                 2070             


Phe Met  Leu Arg Asp Gly Thr  Val Thr Thr Asp Trp  Lys Thr Leu 
    2075                 2080                 2085             


Val Gln  Glu Trp Thr Val Gln  Arg Pro Gly Gln Thr  Cys Gln Pro 
    2090                 2095                 2100             


Ile Leu  Glu Glu Gln Cys Leu  Val Pro Asp Ser Ser  His Cys Gln 
    2105                 2110                 2115             


Val Leu  Leu Leu Pro Leu Phe  Ala Glu Cys His Lys  Val Leu Ala 
    2120                 2125                 2130             


Pro Ala  Thr Phe Tyr Ala Ile  Cys Gln Gln Asp Ser  Cys His Gln 
    2135                 2140                 2145             


Glu Gln  Val Cys Glu Val Ile  Ala Ser Tyr Ala His  Leu Cys Arg 
    2150                 2155                 2160             


Thr Asn  Gly Val Cys Val Asp  Trp Arg Thr Pro Asp  Phe Cys Ala 
    2165                 2170                 2175             


Met Ser  Cys Pro Pro Ser Leu  Val Tyr Asn His Cys  Glu His Gly 
    2180                 2185                 2190             


Cys Pro  Arg His Cys Asp Gly  Asn Val Ser Ser Cys  Gly Asp His 
    2195                 2200                 2205             


Pro Ser  Glu Gly Cys Phe Cys  Pro Pro Asp Lys Val  Met Leu Glu 
    2210                 2215                 2220             


Gly Ser  Cys Val Pro Glu Glu  Ala Cys Thr Gln Cys  Ile Gly Glu 
    2225                 2230                 2235             


Asp Gly  Val Gln His Gln Phe  Leu Glu Ala Trp Val  Pro Asp His 
    2240                 2245                 2250             


Gln Pro  Cys Gln Ile Cys Thr  Cys Leu Ser Gly Arg  Lys Val Asn 
    2255                 2260                 2265             


Cys Thr  Thr Gln Pro Cys Pro  Thr Ala Lys Ala Pro  Thr Cys Gly 
    2270                 2275                 2280             


Leu Cys  Glu Val Ala Arg Leu  Arg Gln Asn Ala Asp  Gln Cys Cys 
    2285                 2290                 2295             


Pro Glu  Tyr Glu Cys Val Cys  Asp Pro Val Ser Cys  Asp Leu Pro 
    2300                 2305                 2310             


Pro Val  Pro His Cys Glu Arg  Gly Leu Gln Pro Thr  Leu Thr Asn 
    2315                 2320                 2325             


Pro Gly  Glu Cys Arg Pro Asn  Phe Thr Cys Ala Cys  Arg Lys Glu 
    2330                 2335                 2340             


Glu Cys  Lys Arg Val Ser Pro  Pro Ser Cys Pro Pro  His Arg Leu 
    2345                 2350                 2355             


Pro Thr  Leu Arg Lys Thr Gln  Cys Cys Asp Glu Tyr  Glu Cys Ala 
    2360                 2365                 2370             


Cys Asn  Cys Val Asn Ser Thr  Val Ser Cys Pro Leu  Gly Tyr Leu 
    2375                 2380                 2385             


Ala Ser  Thr Ala Thr Asn Asp  Cys Gly Cys Thr Thr  Thr Thr Cys 
    2390                 2395                 2400             


Leu Pro  Asp Lys Val Cys Val  His Arg Ser Thr Ile  Tyr Pro Val 
    2405                 2410                 2415             


Gly Gln  Phe Trp Glu Glu Gly  Cys Asp Val Cys Thr  Cys Thr Asp 
    2420                 2425                 2430             


Met Glu  Asp Ala Val Met Gly  Leu Arg Val Ala Gln  Cys Ser Gln 
    2435                 2440                 2445             


Lys Pro  Cys Glu Asp Ser Cys  Arg Ser Gly Phe Thr  Tyr Val Leu 
    2450                 2455                 2460             


His Glu  Gly Glu Cys Cys Gly  Arg Cys Leu Pro Ser  Ala Cys Glu 
    2465                 2470                 2475             


Val Val  Thr Gly Ser Pro Arg  Gly Asp Ser Gln Ser  Ser Trp Lys 
    2480                 2485                 2490             


Ser Val  Gly Ser Gln Trp Ala  Ser Pro Glu Asn Pro  Cys Leu Ile 
    2495                 2500                 2505             


Asn Glu  Cys Val Arg Val Lys  Glu Glu Val Phe Ile  Gln Gln Arg 
    2510                 2515                 2520             


Asn Val  Ser Cys Pro Gln Leu  Glu Val Pro Val Cys  Pro Ser Gly 
    2525                 2530                 2535             


Phe Gln  Leu Ser Cys Lys Thr  Ser Ala Cys Cys Pro  Ser Cys Arg 
    2540                 2545                 2550             


Cys Glu  Arg Met Glu Ala Cys  Met Leu Asn Gly Thr  Val Ile Gly 
    2555                 2560                 2565             


Pro Gly  Lys Thr Val Met Ile  Asp Val Cys Thr Thr  Cys Arg Cys 
    2570                 2575                 2580             


Met Val  Gln Val Gly Val Ile  Ser Gly Phe Lys Leu  Glu Cys Arg 
    2585                 2590                 2595             


Lys Thr  Thr Cys Asn Pro Cys  Pro Leu Gly Tyr Lys  Glu Glu Asn 
    2600                 2605                 2610             


Asn Thr  Gly Glu Cys Cys Gly  Arg Cys Leu Pro Thr  Ala Cys Thr 
    2615                 2620                 2625             


Ile Gln  Leu Arg Gly Gly Gln  Ile Met Thr Leu Lys  Arg Asp Glu 
    2630                 2635                 2640             


Thr Leu  Gln Asp Gly Cys Asp  Thr His Phe Cys Lys  Val Asn Glu 
    2645                 2650                 2655             


Arg Gly  Glu Tyr Phe Trp Glu  Lys Arg Val Thr Gly  Cys Pro Pro 
    2660                 2665                 2670             


Phe Asp  Glu His Lys Cys Leu  Ala Glu Gly Gly Lys  Ile Met Lys 
    2675                 2680                 2685             


Ile Pro  Gly Thr Cys Cys Asp  Thr Cys Glu Glu Pro  Glu Cys Asn 
    2690                 2695                 2700             


Asp Ile  Thr Ala Arg Leu Gln  Tyr Val Lys Val Gly  Ser Cys Lys 
    2705                 2710                 2715             


Ser Glu  Val Glu Val Asp Ile  His Tyr Cys Gln Gly  Lys Cys Ala 
    2720                 2725                 2730             


Ser Lys  Ala Met Tyr Ser Ile  Asp Ile Asn Asp Val  Gln Asp Gln 
    2735                 2740                 2745             


Cys Ser  Cys Cys Ser Pro Thr  Arg Thr Glu Pro Met  Gln Val Ala 
    2750                 2755                 2760             


Leu His  Cys Thr Asn Gly Ser  Val Val Tyr His Glu  Val Leu Asn 
    2765                 2770                 2775             


Ala Met  Glu Cys Lys Cys Ser  Pro Arg Lys Cys Ser  Lys 
    2780                 2785                 2790     


<210>  41
<211>  1663
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  41

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Asp Lys Thr His Thr Cys Pro 
        755                 760                 765             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    770                 775                 780                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
785                 790                 795                 800 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                805                 810                 815     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            820                 825                 830         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        835                 840                 845             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    850                 855                 860                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
865                 870                 875                 880 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                885                 890                 895     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            900                 905                 910         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        915                 920                 925             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    930                 935                 940                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
945                 950                 955                 960 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                965                 970                 975     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Asp Gln Glu Glu 
            980                 985                 990         


Ile Asp Tyr Asp Asp Thr Ile Ser  Val Glu Met Lys Lys  Glu Asp Phe 
        995                 1000                 1005             


Asp Ile  Tyr Asp Glu Asp Glu  Asn Gln Ser Pro Arg  Ser Phe Gln 
    1010                 1015                 1020             


Lys Lys  Thr Arg His Tyr Phe  Ile Ala Ala Val Glu  Arg Leu Trp 
    1025                 1030                 1035             


Asp Tyr  Gly Met Ser Ser Ser  Pro His Val Leu Arg  Asn Arg Ala 
    1040                 1045                 1050             


Gln Ser  Gly Ser Val Pro Gln  Phe Lys Lys Val Val  Phe Gln Glu 
    1055                 1060                 1065             


Phe Thr  Asp Gly Ser Phe Thr  Gln Pro Leu Tyr Arg  Gly Glu Leu 
    1070                 1075                 1080             


Asn Glu  His Leu Gly Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val 
    1085                 1090                 1095             


Glu Asp  Asn Ile Met Val Thr  Phe Arg Asn Gln Ala  Ser Arg Pro 
    1100                 1105                 1110             


Tyr Ser  Phe Tyr Ser Ser Leu  Ile Ser Tyr Glu Glu  Asp Gln Arg 
    1115                 1120                 1125             


Gln Gly  Ala Glu Pro Arg Lys  Asn Phe Val Lys Pro  Asn Glu Thr 
    1130                 1135                 1140             


Lys Thr  Tyr Phe Trp Lys Val  Gln His His Met Ala  Pro Thr Lys 
    1145                 1150                 1155             


Asp Glu  Phe Asp Cys Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp 
    1160                 1165                 1170             


Leu Glu  Lys Asp Val His Ser  Gly Leu Ile Gly Pro  Leu Leu Val 
    1175                 1180                 1185             


Cys His  Thr Asn Thr Leu Asn  Pro Ala His Gly Arg  Gln Val Thr 
    1190                 1195                 1200             


Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
    1205                 1210                 1215             


Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
    1220                 1225                 1230             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1235                 1240                 1245             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1250                 1255                 1260             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1265                 1270                 1275             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1280                 1285                 1290             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1295                 1300                 1305             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1310                 1315                 1320             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1325                 1330                 1335             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1340                 1345                 1350             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1355                 1360                 1365             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1370                 1375                 1380             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1385                 1390                 1395             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1400                 1405                 1410             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1415                 1420                 1425             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1430                 1435                 1440             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1445                 1450                 1455             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1460                 1465                 1470             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1475                 1480                 1485             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1490                 1495                 1500             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1505                 1510                 1515             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1520                 1525                 1530             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1535                 1540                 1545             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1550                 1555                 1560             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1565                 1570                 1575             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1580                 1585                 1590             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1595                 1600                 1605             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1610                 1615                 1620             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1625                 1630                 1635             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1640                 1645                 1650             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 
    1655                 1660             


<210>  42
<211>  1464
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  42

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Ser Ser Ser Ser Lys Ala Pro 
        755                 760                 765             


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
    770                 775                 780                 


Pro Ile Leu Pro Gln Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile 
785                 790                 795                 800 


Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu 
                805                 810                 815     


Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile 
            820                 825                 830         


Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His 
        835                 840                 845             


Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys 
    850                 855                 860                 


Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr 
865                 870                 875                 880 


Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg 
                885                 890                 895     


Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser 
            900                 905                 910         


Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln 
        915                 920                 925             


Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr 
    930                 935                 940                 


Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp 
945                 950                 955                 960 


Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu 
                965                 970                 975     


Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr 
            980                 985                 990         


Asn Thr Leu Asn Pro Ala His Gly  Arg Gln Val Thr Val  Gln Glu Phe 
        995                 1000                 1005             


Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe 
    1010                 1015                 1020             


Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln 
    1025                 1030                 1035             


Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile 
    1040                 1045                 1050             


Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln 
    1055                 1060                 1065             


Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu 
    1070                 1075                 1080             


Asn Ile  His Ser Ile His Phe  Ser Gly His Val Phe  Thr Val Arg 
    1085                 1090                 1095             


Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly 
    1100                 1105                 1110             


Val Phe  Glu Thr Val Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp 
    1115                 1120                 1125             


Arg Val  Glu Cys Leu Ile Gly  Glu His Leu His Ala  Gly Met Ser 
    1130                 1135                 1140             


Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly 
    1145                 1150                 1155             


Met Ala  Ser Gly His Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly 
    1160                 1165                 1170             


Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser 
    1175                 1180                 1185             


Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile 
    1190                 1195                 1200             


Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile His Gly  Ile Lys Thr 
    1205                 1210                 1215             


Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe 
    1220                 1225                 1230             


Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg 
    1235                 1240                 1245             


Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe Phe Gly  Asn Val Asp 
    1250                 1255                 1260             


Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala 
    1265                 1270                 1275             


Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr Ser Ile  Arg Ser Thr 
    1280                 1285                 1290             


Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met 
    1295                 1300                 1305             


Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr 
    1310                 1315                 1320             


Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser 
    1325                 1330                 1335             


Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro 
    1340                 1345                 1350             


Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys 
    1355                 1360                 1365             


Thr Met  Lys Val Thr Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu 
    1370                 1375                 1380             


Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln 
    1385                 1390                 1395             


Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys 
    1400                 1405                 1410             


Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser 
    1415                 1420                 1425             


Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln 
    1430                 1435                 1440             


Ser Trp  Val His Gln Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys 
    1445                 1450                 1455             


Glu Ala  Gln Asp Leu Tyr 
    1460                 


<210>  43
<211>  2021
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  43

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Asp Ala His Lys Ser Glu Val 
        755                 760                 765             


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
    770                 775                 780                 


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
785                 790                 795                 800 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
                805                 810                 815     


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            820                 825                 830         


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
        835                 840                 845             


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    850                 855                 860                 


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
865                 870                 875                 880 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
                885                 890                 895     


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            900                 905                 910         


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
        915                 920                 925             


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
    930                 935                 940                 


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
945                 950                 955                 960 


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
                965                 970                 975     


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
            980                 985                 990         


Ser Lys Leu Val Thr Asp Leu Thr  Lys Val His Thr Glu  Cys Cys His 
        995                 1000                 1005             


Gly Asp  Leu Leu Glu Cys Ala  Asp Asp Arg Ala Asp  Leu Ala Lys 
    1010                 1015                 1020             


Tyr Ile  Cys Glu Asn Gln Asp  Ser Ile Ser Ser Lys  Leu Lys Glu 
    1025                 1030                 1035             


Cys Cys  Glu Lys Pro Leu Leu  Glu Lys Ser His Cys  Ile Ala Glu 
    1040                 1045                 1050             


Val Glu  Asn Asp Glu Met Pro  Ala Asp Leu Pro Ser  Leu Ala Ala 
    1055                 1060                 1065             


Asp Phe  Val Glu Ser Lys Asp  Val Cys Lys Asn Tyr  Ala Glu Ala 
    1070                 1075                 1080             


Lys Asp  Val Phe Leu Gly Met  Phe Leu Tyr Glu Tyr  Ala Arg Arg 
    1085                 1090                 1095             


His Pro  Asp Tyr Ser Val Val  Leu Leu Leu Arg Leu  Ala Lys Thr 
    1100                 1105                 1110             


Tyr Glu  Thr Thr Leu Glu Lys  Cys Cys Ala Ala Ala  Asp Pro His 
    1115                 1120                 1125             


Glu Cys  Tyr Ala Lys Val Phe  Asp Glu Phe Lys Pro  Leu Val Glu 
    1130                 1135                 1140             


Glu Pro  Gln Asn Leu Ile Lys  Gln Asn Cys Glu Leu  Phe Glu Gln 
    1145                 1150                 1155             


Leu Gly  Glu Tyr Lys Phe Gln  Asn Ala Leu Leu Val  Arg Tyr Thr 
    1160                 1165                 1170             


Lys Lys  Val Pro Gln Val Ser  Thr Pro Thr Leu Val  Glu Val Ser 
    1175                 1180                 1185             


Arg Asn  Leu Gly Lys Val Gly  Ser Lys Cys Cys Lys  His Pro Glu 
    1190                 1195                 1200             


Ala Lys  Arg Met Pro Cys Ala  Glu Asp Tyr Leu Ser  Val Val Leu 
    1205                 1210                 1215             


Asn Gln  Leu Cys Val Leu His  Glu Lys Thr Pro Val  Ser Asp Arg 
    1220                 1225                 1230             


Val Thr  Lys Cys Cys Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys 
    1235                 1240                 1245             


Phe Ser  Ala Leu Glu Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe 
    1250                 1255                 1260             


Asn Ala  Glu Thr Phe Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser 
    1265                 1270                 1275             


Glu Lys  Glu Arg Gln Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu 
    1280                 1285                 1290             


Val Lys  His Lys Pro Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val 
    1295                 1300                 1305             


Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp 
    1310                 1315                 1320             


Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala 
    1325                 1330                 1335             


Ala Ser  Gln Ala Ala Leu Gly  Leu Asp Gln Glu Glu  Ile Asp Tyr 
    1340                 1345                 1350             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1355                 1360                 1365             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1370                 1375                 1380             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1385                 1390                 1395             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1400                 1405                 1410             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1415                 1420                 1425             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1430                 1435                 1440             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1445                 1450                 1455             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1460                 1465                 1470             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1475                 1480                 1485             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1490                 1495                 1500             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1505                 1510                 1515             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1520                 1525                 1530             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1535                 1540                 1545             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1550                 1555                 1560             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1565                 1570                 1575             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1580                 1585                 1590             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1595                 1600                 1605             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1610                 1615                 1620             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1625                 1630                 1635             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1640                 1645                 1650             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1655                 1660                 1665             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    1670                 1675                 1680             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    1685                 1690                 1695             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    1700                 1705                 1710             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    1715                 1720                 1725             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    1730                 1735                 1740             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    1745                 1750                 1755             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    1760                 1765                 1770             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    1775                 1780                 1785             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    1790                 1795                 1800             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    1805                 1810                 1815             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    1820                 1825                 1830             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    1835                 1840                 1845             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    1850                 1855                 1860             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    1865                 1870                 1875             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    1880                 1885                 1890             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    1895                 1900                 1905             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    1910                 1915                 1920             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    1925                 1930                 1935             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    1940                 1945                 1950             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    1955                 1960                 1965             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    1970                 1975                 1980             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    1985                 1990                 1995             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2000                 2005                 2010             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2015                 2020     


<210>  44
<211>  1709
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  44

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Gln Val Asp Thr Thr Lys Ala 
        755                 760                 765             


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Val Phe Gln Glu Glu Thr 
    770                 775                 780                 


Val Thr Leu His Cys Glu Val Leu His Leu Pro Gly Ser Ser Ser Thr 
785                 790                 795                 800 


Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln Thr Ser Thr Pro Ser Tyr 
                805                 810                 815     


Arg Ile Thr Ser Ala Ser Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln 
            820                 825                 830         


Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile Gln Leu Glu Ile His Arg 
        835                 840                 845             


Gly Trp Leu Leu Leu Gln Val Ser Ser Arg Val Phe Thr Glu Gly Glu 
    850                 855                 860                 


Pro Leu Ala Leu Arg Cys His Ala Trp Lys Asp Lys Leu Val Tyr Asn 
865                 870                 875                 880 


Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe Lys Phe Phe His Trp Asn 
                885                 890                 895     


Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile Ser His Asn Gly Thr Tyr 
            900                 905                 910         


His Cys Ser Gly Met Gly Lys His Arg Tyr Thr Ser Ala Gly Ile Ser 
        915                 920                 925             


Val Thr Val Lys Glu Leu Phe Pro Ala Pro Val Leu Asn Ala Ser Val 
    930                 935                 940                 


Thr Ser Pro Leu Leu Glu Gly Asn Leu Val Thr Leu Ser Cys Glu Thr 
945                 950                 955                 960 


Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu Tyr Phe Ser Phe Tyr 
                965                 970                 975     


Met Gly Ser Lys Thr Leu Arg Gly Arg Asn Thr Ser Ser Glu Tyr Gln 
            980                 985                 990         


Ile Leu Thr Ala Arg Arg Glu Asp  Ser Gly Leu Tyr Trp  Cys Glu Ala 
        995                 1000                 1005             


Ala Thr  Glu Asp Gly Asn Val  Leu Lys Arg Ser Pro  Glu Leu Glu 
    1010                 1015                 1020             


Leu Gln  Val Leu Gly Leu Gln  Leu Pro Thr Pro Asp  Gln Glu Glu 
    1025                 1030                 1035             


Ile Asp  Tyr Asp Asp Thr Ile  Ser Val Glu Met Lys  Lys Glu Asp 
    1040                 1045                 1050             


Phe Asp  Ile Tyr Asp Glu Asp  Glu Asn Gln Ser Pro  Arg Ser Phe 
    1055                 1060                 1065             


Gln Lys  Lys Thr Arg His Tyr  Phe Ile Ala Ala Val  Glu Arg Leu 
    1070                 1075                 1080             


Trp Asp  Tyr Gly Met Ser Ser  Ser Pro His Val Leu  Arg Asn Arg 
    1085                 1090                 1095             


Ala Gln  Ser Gly Ser Val Pro  Gln Phe Lys Lys Val  Val Phe Gln 
    1100                 1105                 1110             


Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Pro Leu Tyr  Arg Gly Glu 
    1115                 1120                 1125             


Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro Tyr Ile  Arg Ala Glu 
    1130                 1135                 1140             


Val Glu  Asp Asn Ile Met Val  Thr Phe Arg Asn Gln  Ala Ser Arg 
    1145                 1150                 1155             


Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser Tyr Glu  Glu Asp Gln 
    1160                 1165                 1170             


Arg Gln  Gly Ala Glu Pro Arg  Lys Asn Phe Val Lys  Pro Asn Glu 
    1175                 1180                 1185             


Thr Lys  Thr Tyr Phe Trp Lys  Val Gln His His Met  Ala Pro Thr 
    1190                 1195                 1200             


Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 
    1205                 1210                 1215             


Asp Leu  Glu Lys Asp Val His  Ser Gly Leu Ile Gly  Pro Leu Leu 
    1220                 1225                 1230             


Val Cys  His Thr Asn Thr Leu  Asn Pro Ala His Gly  Arg Gln Val 
    1235                 1240                 1245             


Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr 
    1250                 1255                 1260             


Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala 
    1265                 1270                 1275             


Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr 
    1280                 1285                 1290             


Arg Phe  His Ala Ile Asn Gly  Tyr Ile Met Asp Thr  Leu Pro Gly 
    1295                 1300                 1305             


Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 
    1310                 1315                 1320             


Met Gly  Ser Asn Glu Asn Ile  His Ser Ile His Phe  Ser Gly His 
    1325                 1330                 1335             


Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Leu Tyr 
    1340                 1345                 1350             


Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val Glu Met  Leu Pro Ser 
    1355                 1360                 1365             


Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu Ile Gly  Glu His Leu 
    1370                 1375                 1380             


His Ala  Gly Met Ser Thr Leu  Phe Leu Val Tyr Ser  Asn Lys Cys 
    1385                 1390                 1395             


Gln Thr  Pro Leu Gly Met Ala  Ser Gly His Ile Arg  Asp Phe Gln 
    1400                 1405                 1410             


Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala 
    1415                 1420                 1425             


Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 
    1430                 1435                 1440             


Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile 
    1445                 1450                 1455             


His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 
    1460                 1465                 1470             


Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 
    1475                 1480                 1485             


Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 
    1490                 1495                 1500             


Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn 
    1505                 1510                 1515             


Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr 
    1520                 1525                 1530             


Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 
    1535                 1540                 1545             


Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser 
    1550                 1555                 1560             


Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 
    1565                 1570                 1575             


Thr Trp  Ser Pro Ser Lys Ala  Arg Leu His Leu Gln  Gly Arg Ser 
    1580                 1585                 1590             


Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln 
    1595                 1600                 1605             


Val Asp  Phe Gln Lys Thr Met  Lys Val Thr Gly Val  Thr Thr Gln 
    1610                 1615                 1620             


Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu 
    1625                 1630                 1635             


Ile Ser  Ser Ser Gln Asp Gly  His Gln Trp Thr Leu  Phe Phe Gln 
    1640                 1645                 1650             


Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr 
    1655                 1660                 1665             


Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu 
    1670                 1675                 1680             


Arg Ile  His Pro Gln Ser Trp  Val His Gln Ile Ala  Leu Arg Met 
    1685                 1690                 1695             


Glu Val  Leu Gly Cys Glu Ala  Gln Asp Leu Tyr 
    1700                 1705                 


<210>  45
<211>  1662
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  45

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Ser Phe Ser Gln Asn Ser Arg 
        755                 760                 765             


His Pro Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu 
    770                 775                 780                 


Asn Asp Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met 
785                 790                 795                 800 


Pro Lys Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg 
                805                 810                 815     


Gln Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala 
            820                 825                 830         


Lys Tyr Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser 
        835                 840                 845             


Asn Asn Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His 
    850                 855                 860                 


Ser Gly Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu 
865                 870                 875                 880 


Asn Glu Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp 
                885                 890                 895     


Phe Lys Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser 
            900                 905                 910         


Asp Asn Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro 
        915                 920                 925             


Ser Met Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly 
    930                 935                 940                 


Lys Lys Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser 
945                 950                 955                 960 


Glu Glu Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser 
                965                 970                 975     


Gln Glu Ser Ser Trp Gly Lys Asn Val Ser Ser Asp Gln Glu Glu Ile 
            980                 985                 990         


Asp Tyr Asp Asp Thr Ile Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp 
        995                 1000                 1005             


Ile Tyr  Asp Glu Asp Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys 
    1010                 1015                 1020             


Lys Thr  Arg His Tyr Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp 
    1025                 1030                 1035             


Tyr Gly  Met Ser Ser Ser Pro  His Val Leu Arg Asn  Arg Ala Gln 
    1040                 1045                 1050             


Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe 
    1055                 1060                 1065             


Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn 
    1070                 1075                 1080             


Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu 
    1085                 1090                 1095             


Asp Asn  Ile Met Val Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr 
    1100                 1105                 1110             


Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln 
    1115                 1120                 1125             


Gly Ala  Glu Pro Arg Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys 
    1130                 1135                 1140             


Thr Tyr  Phe Trp Lys Val Gln  His His Met Ala Pro  Thr Lys Asp 
    1145                 1150                 1155             


Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu 
    1160                 1165                 1170             


Glu Lys  Asp Val His Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys 
    1175                 1180                 1185             


His Thr  Asn Thr Leu Asn Pro  Ala His Gly Arg Gln  Val Thr Val 
    1190                 1195                 1200             


Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser 
    1205                 1210                 1215             


Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys 
    1220                 1225                 1230             


Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe 
    1235                 1240                 1245             


His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val 
    1250                 1255                 1260             


Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly 
    1265                 1270                 1275             


Ser Asn  Glu Asn Ile His Ser  Ile His Phe Ser Gly  His Val Phe 
    1280                 1285                 1290             


Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu 
    1295                 1300                 1305             


Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala 
    1310                 1315                 1320             


Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly Glu His  Leu His Ala 
    1325                 1330                 1335             


Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr 
    1340                 1345                 1350             


Pro Leu  Gly Met Ala Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr 
    1355                 1360                 1365             


Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu 
    1370                 1375                 1380             


His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe 
    1385                 1390                 1395             


Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro Met Ile  Ile His Gly 
    1400                 1405                 1410             


Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile 
    1415                 1420                 1425             


Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln 
    1430                 1435                 1440             


Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly 
    1445                 1450                 1455             


Asn Val  Asp Ser Ser Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro 
    1460                 1465                 1470             


Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro Thr His  Tyr Ser Ile 
    1475                 1480                 1485             


Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser 
    1490                 1495                 1500             


Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala 
    1505                 1510                 1515             


Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp 
    1520                 1525                 1530             


Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala 
    1535                 1540                 1545             


Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp 
    1550                 1555                 1560             


Phe Gln  Lys Thr Met Lys Val  Thr Gly Val Thr Thr  Gln Gly Val 
    1565                 1570                 1575             


Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser 
    1580                 1585                 1590             


Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly 
    1595                 1600                 1605             


Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val 
    1610                 1615                 1620             


Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile 
    1625                 1630                 1635             


His Pro  Gln Ser Trp Val His  Gln Ile Ala Leu Arg  Met Glu Val 
    1640                 1645                 1650             


Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    1655                 1660         


<210>  46
<211>  2030
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  46

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Asp Ala His Lys Ser Glu Val 
        755                 760                 765             


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
    770                 775                 780                 


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
785                 790                 795                 800 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
                805                 810                 815     


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            820                 825                 830         


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
        835                 840                 845             


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    850                 855                 860                 


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
865                 870                 875                 880 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
                885                 890                 895     


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            900                 905                 910         


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
        915                 920                 925             


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
    930                 935                 940                 


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
945                 950                 955                 960 


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
                965                 970                 975     


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
            980                 985                 990         


Ser Lys Leu Val Thr Asp Leu Thr  Lys Val His Thr Glu  Cys Cys His 
        995                 1000                 1005             


Gly Asp  Leu Leu Glu Cys Ala  Asp Asp Arg Ala Asp  Leu Ala Lys 
    1010                 1015                 1020             


Tyr Ile  Cys Glu Asn Gln Asp  Ser Ile Ser Ser Lys  Leu Lys Glu 
    1025                 1030                 1035             


Cys Cys  Glu Lys Pro Leu Leu  Glu Lys Ser His Cys  Ile Ala Glu 
    1040                 1045                 1050             


Val Glu  Asn Asp Glu Met Pro  Ala Asp Leu Pro Ser  Leu Ala Ala 
    1055                 1060                 1065             


Asp Phe  Val Glu Ser Lys Asp  Val Cys Lys Asn Tyr  Ala Glu Ala 
    1070                 1075                 1080             


Lys Asp  Val Phe Leu Gly Met  Phe Leu Tyr Glu Tyr  Ala Arg Arg 
    1085                 1090                 1095             


His Pro  Asp Tyr Ser Val Val  Leu Leu Leu Arg Leu  Ala Lys Thr 
    1100                 1105                 1110             


Tyr Glu  Thr Thr Leu Glu Lys  Cys Cys Ala Ala Ala  Asp Pro His 
    1115                 1120                 1125             


Glu Cys  Tyr Ala Lys Val Phe  Asp Glu Phe Lys Pro  Leu Val Glu 
    1130                 1135                 1140             


Glu Pro  Gln Asn Leu Ile Lys  Gln Asn Cys Glu Leu  Phe Glu Gln 
    1145                 1150                 1155             


Leu Gly  Glu Tyr Lys Phe Gln  Asn Ala Leu Leu Val  Arg Tyr Thr 
    1160                 1165                 1170             


Lys Lys  Val Pro Gln Val Ser  Thr Pro Thr Leu Val  Glu Val Ser 
    1175                 1180                 1185             


Arg Asn  Leu Gly Lys Val Gly  Ser Lys Cys Cys Lys  His Pro Glu 
    1190                 1195                 1200             


Ala Lys  Arg Met Pro Cys Ala  Glu Asp Tyr Leu Ser  Val Val Leu 
    1205                 1210                 1215             


Asn Gln  Leu Cys Val Leu His  Glu Lys Thr Pro Val  Ser Asp Arg 
    1220                 1225                 1230             


Val Thr  Lys Cys Cys Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys 
    1235                 1240                 1245             


Phe Ser  Ala Leu Glu Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe 
    1250                 1255                 1260             


Asn Ala  Glu Thr Phe Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser 
    1265                 1270                 1275             


Glu Lys  Glu Arg Gln Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu 
    1280                 1285                 1290             


Val Lys  His Lys Pro Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val 
    1295                 1300                 1305             


Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp 
    1310                 1315                 1320             


Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala 
    1325                 1330                 1335             


Ala Ser  Gln Ala Ala Leu Gly  Leu Glu Ile Thr Arg  Thr Thr Leu 
    1340                 1345                 1350             


Gln Ser  Asp Gln Glu Glu Ile  Asp Tyr Asp Asp Thr  Ile Ser Val 
    1355                 1360                 1365             


Glu Met  Lys Lys Glu Asp Phe  Asp Ile Tyr Asp Glu  Asp Glu Asn 
    1370                 1375                 1380             


Gln Ser  Pro Arg Ser Phe Gln  Lys Lys Thr Arg His  Tyr Phe Ile 
    1385                 1390                 1395             


Ala Ala  Val Glu Arg Leu Trp  Asp Tyr Gly Met Ser  Ser Ser Pro 
    1400                 1405                 1410             


His Val  Leu Arg Asn Arg Ala  Gln Ser Gly Ser Val  Pro Gln Phe 
    1415                 1420                 1425             


Lys Lys  Val Val Phe Gln Glu  Phe Thr Asp Gly Ser  Phe Thr Gln 
    1430                 1435                 1440             


Pro Leu  Tyr Arg Gly Glu Leu  Asn Glu His Leu Gly  Leu Leu Gly 
    1445                 1450                 1455             


Pro Tyr  Ile Arg Ala Glu Val  Glu Asp Asn Ile Met  Val Thr Phe 
    1460                 1465                 1470             


Arg Asn  Gln Ala Ser Arg Pro  Tyr Ser Phe Tyr Ser  Ser Leu Ile 
    1475                 1480                 1485             


Ser Tyr  Glu Glu Asp Gln Arg  Gln Gly Ala Glu Pro  Arg Lys Asn 
    1490                 1495                 1500             


Phe Val  Lys Pro Asn Glu Thr  Lys Thr Tyr Phe Trp  Lys Val Gln 
    1505                 1510                 1515             


His His  Met Ala Pro Thr Lys  Asp Glu Phe Asp Cys  Lys Ala Trp 
    1520                 1525                 1530             


Ala Tyr  Phe Ser Asp Val Asp  Leu Glu Lys Asp Val  His Ser Gly 
    1535                 1540                 1545             


Leu Ile  Gly Pro Leu Leu Val  Cys His Thr Asn Thr  Leu Asn Pro 
    1550                 1555                 1560             


Ala His  Gly Arg Gln Val Thr  Val Gln Glu Phe Ala  Leu Phe Phe 
    1565                 1570                 1575             


Thr Ile  Phe Asp Glu Thr Lys  Ser Trp Tyr Phe Thr  Glu Asn Met 
    1580                 1585                 1590             


Glu Arg  Asn Cys Arg Ala Pro  Cys Asn Ile Gln Met  Glu Asp Pro 
    1595                 1600                 1605             


Thr Phe  Lys Glu Asn Tyr Arg  Phe His Ala Ile Asn  Gly Tyr Ile 
    1610                 1615                 1620             


Met Asp  Thr Leu Pro Gly Leu  Val Met Ala Gln Asp  Gln Arg Ile 
    1625                 1630                 1635             


Arg Trp  Tyr Leu Leu Ser Met  Gly Ser Asn Glu Asn  Ile His Ser 
    1640                 1645                 1650             


Ile His  Phe Ser Gly His Val  Phe Thr Val Arg Lys  Lys Glu Glu 
    1655                 1660                 1665             


Tyr Lys  Met Ala Leu Tyr Asn  Leu Tyr Pro Gly Val  Phe Glu Thr 
    1670                 1675                 1680             


Val Glu  Met Leu Pro Ser Lys  Ala Gly Ile Trp Arg  Val Glu Cys 
    1685                 1690                 1695             


Leu Ile  Gly Glu His Leu His  Ala Gly Met Ser Thr  Leu Phe Leu 
    1700                 1705                 1710             


Val Tyr  Ser Asn Lys Cys Gln  Thr Pro Leu Gly Met  Ala Ser Gly 
    1715                 1720                 1725             


His Ile  Arg Asp Phe Gln Ile  Thr Ala Ser Gly Gln  Tyr Gly Gln 
    1730                 1735                 1740             


Trp Ala  Pro Lys Leu Ala Arg  Leu His Tyr Ser Gly  Ser Ile Asn 
    1745                 1750                 1755             


Ala Trp  Ser Thr Lys Glu Pro  Phe Ser Trp Ile Lys  Val Asp Leu 
    1760                 1765                 1770             


Leu Ala  Pro Met Ile Ile His  Gly Ile Lys Thr Gln  Gly Ala Arg 
    1775                 1780                 1785             


Gln Lys  Phe Ser Ser Leu Tyr  Ile Ser Gln Phe Ile  Ile Met Tyr 
    1790                 1795                 1800             


Ser Leu  Asp Gly Lys Lys Trp  Gln Thr Tyr Arg Gly  Asn Ser Thr 
    1805                 1810                 1815             


Gly Thr  Leu Met Val Phe Phe  Gly Asn Val Asp Ser  Ser Gly Ile 
    1820                 1825                 1830             


Lys His  Asn Ile Phe Asn Pro  Pro Ile Ile Ala Arg  Tyr Ile Arg 
    1835                 1840                 1845             


Leu His  Pro Thr His Tyr Ser  Ile Arg Ser Thr Leu  Arg Met Glu 
    1850                 1855                 1860             


Leu Met  Gly Cys Asp Leu Asn  Ser Cys Ser Met Pro  Leu Gly Met 
    1865                 1870                 1875             


Glu Ser  Lys Ala Ile Ser Asp  Ala Gln Ile Thr Ala  Ser Ser Tyr 
    1880                 1885                 1890             


Phe Thr  Asn Met Phe Ala Thr  Trp Ser Pro Ser Lys  Ala Arg Leu 
    1895                 1900                 1905             


His Leu  Gln Gly Arg Ser Asn  Ala Trp Arg Pro Gln  Val Asn Asn 
    1910                 1915                 1920             


Pro Lys  Glu Trp Leu Gln Val  Asp Phe Gln Lys Thr  Met Lys Val 
    1925                 1930                 1935             


Thr Gly  Val Thr Thr Gln Gly  Val Lys Ser Leu Leu  Thr Ser Met 
    1940                 1945                 1950             


Tyr Val  Lys Glu Phe Leu Ile  Ser Ser Ser Gln Asp  Gly His Gln 
    1955                 1960                 1965             


Trp Thr  Leu Phe Phe Gln Asn  Gly Lys Val Lys Val  Phe Gln Gly 
    1970                 1975                 1980             


Asn Gln  Asp Ser Phe Thr Pro  Val Val Asn Ser Leu  Asp Pro Pro 
    1985                 1990                 1995             


Leu Leu  Thr Arg Tyr Leu Arg  Ile His Pro Gln Ser  Trp Val His 
    2000                 2005                 2010             


Gln Ile  Ala Leu Arg Met Glu  Val Leu Gly Cys Glu  Ala Gln Asp 
    2015                 2020                 2025             


Leu Tyr  
    2030 


<210>  47
<211>  1718
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  47

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Gln Val Asp Thr Thr Lys Ala 
        755                 760                 765             


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Val Phe Gln Glu Glu Thr 
    770                 775                 780                 


Val Thr Leu His Cys Glu Val Leu His Leu Pro Gly Ser Ser Ser Thr 
785                 790                 795                 800 


Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln Thr Ser Thr Pro Ser Tyr 
                805                 810                 815     


Arg Ile Thr Ser Ala Ser Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln 
            820                 825                 830         


Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile Gln Leu Glu Ile His Arg 
        835                 840                 845             


Gly Trp Leu Leu Leu Gln Val Ser Ser Arg Val Phe Thr Glu Gly Glu 
    850                 855                 860                 


Pro Leu Ala Leu Arg Cys His Ala Trp Lys Asp Lys Leu Val Tyr Asn 
865                 870                 875                 880 


Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe Lys Phe Phe His Trp Asn 
                885                 890                 895     


Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile Ser His Asn Gly Thr Tyr 
            900                 905                 910         


His Cys Ser Gly Met Gly Lys His Arg Tyr Thr Ser Ala Gly Ile Ser 
        915                 920                 925             


Val Thr Val Lys Glu Leu Phe Pro Ala Pro Val Leu Asn Ala Ser Val 
    930                 935                 940                 


Thr Ser Pro Leu Leu Glu Gly Asn Leu Val Thr Leu Ser Cys Glu Thr 
945                 950                 955                 960 


Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu Tyr Phe Ser Phe Tyr 
                965                 970                 975     


Met Gly Ser Lys Thr Leu Arg Gly Arg Asn Thr Ser Ser Glu Tyr Gln 
            980                 985                 990         


Ile Leu Thr Ala Arg Arg Glu Asp  Ser Gly Leu Tyr Trp  Cys Glu Ala 
        995                 1000                 1005             


Ala Thr  Glu Asp Gly Asn Val  Leu Lys Arg Ser Pro  Glu Leu Glu 
    1010                 1015                 1020             


Leu Gln  Val Leu Gly Leu Gln  Leu Pro Thr Pro Glu  Ile Thr Arg 
    1025                 1030                 1035             


Thr Thr  Leu Gln Ser Asp Gln  Glu Glu Ile Asp Tyr  Asp Asp Thr 
    1040                 1045                 1050             


Ile Ser  Val Glu Met Lys Lys  Glu Asp Phe Asp Ile  Tyr Asp Glu 
    1055                 1060                 1065             


Asp Glu  Asn Gln Ser Pro Arg  Ser Phe Gln Lys Lys  Thr Arg His 
    1070                 1075                 1080             


Tyr Phe  Ile Ala Ala Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser 
    1085                 1090                 1095             


Ser Ser  Pro His Val Leu Arg  Asn Arg Ala Gln Ser  Gly Ser Val 
    1100                 1105                 1110             


Pro Gln  Phe Lys Lys Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser 
    1115                 1120                 1125             


Phe Thr  Gln Pro Leu Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly 
    1130                 1135                 1140             


Leu Leu  Gly Pro Tyr Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met 
    1145                 1150                 1155             


Val Thr  Phe Arg Asn Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser 
    1160                 1165                 1170             


Ser Leu  Ile Ser Tyr Glu Glu  Asp Gln Arg Gln Gly  Ala Glu Pro 
    1175                 1180                 1185             


Arg Lys  Asn Phe Val Lys Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp 
    1190                 1195                 1200             


Lys Val  Gln His His Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys 
    1205                 1210                 1215             


Lys Ala  Trp Ala Tyr Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val 
    1220                 1225                 1230             


His Ser  Gly Leu Ile Gly Pro  Leu Leu Val Cys His  Thr Asn Thr 
    1235                 1240                 1245             


Leu Asn  Pro Ala His Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala 
    1250                 1255                 1260             


Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr 
    1265                 1270                 1275             


Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro Cys Asn  Ile Gln Met 
    1280                 1285                 1290             


Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn 
    1295                 1300                 1305             


Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp 
    1310                 1315                 1320             


Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn 
    1325                 1330                 1335             


Ile His  Ser Ile His Phe Ser  Gly His Val Phe Thr  Val Arg Lys 
    1340                 1345                 1350             


Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn Leu Tyr  Pro Gly Val 
    1355                 1360                 1365             


Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg 
    1370                 1375                 1380             


Val Glu  Cys Leu Ile Gly Glu  His Leu His Ala Gly  Met Ser Thr 
    1385                 1390                 1395             


Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln Thr Pro  Leu Gly Met 
    1400                 1405                 1410             


Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln 
    1415                 1420                 1425             


Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly 
    1430                 1435                 1440             


Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys 
    1445                 1450                 1455             


Val Asp  Leu Leu Ala Pro Met  Ile Ile His Gly Ile  Lys Thr Gln 
    1460                 1465                 1470             


Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile 
    1475                 1480                 1485             


Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly 
    1490                 1495                 1500             


Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe Gly Asn  Val Asp Ser 
    1505                 1510                 1515             


Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg 
    1520                 1525                 1530             


Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu 
    1535                 1540                 1545             


Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro 
    1550                 1555                 1560             


Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala 
    1565                 1570                 1575             


Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys 
    1580                 1585                 1590             


Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln 
    1595                 1600                 1605             


Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr 
    1610                 1615                 1620             


Met Lys  Val Thr Gly Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu 
    1625                 1630                 1635             


Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp 
    1640                 1645                 1650             


Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val 
    1655                 1660                 1665             


Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu 
    1670                 1675                 1680             


Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser 
    1685                 1690                 1695             


Trp Val  His Gln Ile Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu 
    1700                 1705                 1710             


Ala Gln  Asp Leu Tyr 
    1715             


<210>  48
<211>  1671
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  48

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Ser Phe Ser Gln Asn Ser Arg 
        755                 760                 765             


His Pro Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu 
    770                 775                 780                 


Asn Asp Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met 
785                 790                 795                 800 


Pro Lys Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg 
                805                 810                 815     


Gln Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala 
            820                 825                 830         


Lys Tyr Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser 
        835                 840                 845             


Asn Asn Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His 
    850                 855                 860                 


Ser Gly Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu 
865                 870                 875                 880 


Asn Glu Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp 
                885                 890                 895     


Phe Lys Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser 
            900                 905                 910         


Asp Asn Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro 
        915                 920                 925             


Ser Met Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly 
    930                 935                 940                 


Lys Lys Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser 
945                 950                 955                 960 


Glu Glu Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser 
                965                 970                 975     


Gln Glu Ser Ser Trp Gly Lys Asn Val Ser Ser Glu Ile Thr Arg Thr 
            980                 985                 990         


Thr Leu Gln Ser Asp Gln Glu Glu  Ile Asp Tyr Asp Asp  Thr Ile Ser 
        995                 1000                 1005             


Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile Tyr Asp  Glu Asp Glu 
    1010                 1015                 1020             


Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys Thr Arg  His Tyr Phe 
    1025                 1030                 1035             


Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr Gly Met  Ser Ser Ser 
    1040                 1045                 1050             


Pro His  Val Leu Arg Asn Arg  Ala Gln Ser Gly Ser  Val Pro Gln 
    1055                 1060                 1065             


Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr Asp Gly  Ser Phe Thr 
    1070                 1075                 1080             


Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu His Leu  Gly Leu Leu 
    1085                 1090                 1095             


Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp Asn Ile  Met Val Thr 
    1100                 1105                 1110             


Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser Phe Tyr  Ser Ser Leu 
    1115                 1120                 1125             


Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly Ala Glu  Pro Arg Lys 
    1130                 1135                 1140             


Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr Tyr Phe  Trp Lys Val 
    1145                 1150                 1155             


Gln His  His Met Ala Pro Thr  Lys Asp Glu Phe Asp  Cys Lys Ala 
    1160                 1165                 1170             


Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu Lys Asp  Val His Ser 
    1175                 1180                 1185             


Gly Leu  Ile Gly Pro Leu Leu  Val Cys His Thr Asn  Thr Leu Asn 
    1190                 1195                 1200             


Pro Ala  His Gly Arg Gln Val  Thr Val Gln Glu Phe  Ala Leu Phe 
    1205                 1210                 1215             


Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp Tyr Phe  Thr Glu Asn 
    1220                 1225                 1230             


Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn Ile Gln  Met Glu Asp 
    1235                 1240                 1245             


Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His Ala Ile  Asn Gly Tyr 
    1250                 1255                 1260             


Ile Met  Asp Thr Leu Pro Gly  Leu Val Met Ala Gln  Asp Gln Arg 
    1265                 1270                 1275             


Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser Asn Glu  Asn Ile His 
    1280                 1285                 1290             


Ser Ile  His Phe Ser Gly His  Val Phe Thr Val Arg  Lys Lys Glu 
    1295                 1300                 1305             


Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr Pro Gly  Val Phe Glu 
    1310                 1315                 1320             


Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly Ile Trp  Arg Val Glu 
    1325                 1330                 1335             


Cys Leu  Ile Gly Glu His Leu  His Ala Gly Met Ser  Thr Leu Phe 
    1340                 1345                 1350             


Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro Leu Gly  Met Ala Ser 
    1355                 1360                 1365             


Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala Ser Gly  Gln Tyr Gly 
    1370                 1375                 1380             


Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His Tyr Ser  Gly Ser Ile 
    1385                 1390                 1395             


Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser Trp Ile  Lys Val Asp 
    1400                 1405                 1410             


Leu Leu  Ala Pro Met Ile Ile  His Gly Ile Lys Thr  Gln Gly Ala 
    1415                 1420                 1425             


Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser Gln Phe  Ile Ile Met 
    1430                 1435                 1440             


Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr Tyr Arg  Gly Asn Ser 
    1445                 1450                 1455             


Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn Val Asp  Ser Ser Gly 
    1460                 1465                 1470             


Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile Ile Ala  Arg Tyr Ile 
    1475                 1480                 1485             


Arg Leu  His Pro Thr His Tyr  Ser Ile Arg Ser Thr  Leu Arg Met 
    1490                 1495                 1500             


Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys Ser Met  Pro Leu Gly 
    1505                 1510                 1515             


Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln Ile Thr  Ala Ser Ser 
    1520                 1525                 1530             


Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser Pro Ser  Lys Ala Arg 
    1535                 1540                 1545             


Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp Arg Pro  Gln Val Asn 
    1550                 1555                 1560             


Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe Gln Lys  Thr Met Lys 
    1565                 1570                 1575             


Val Thr  Gly Val Thr Thr Gln  Gly Val Lys Ser Leu  Leu Thr Ser 
    1580                 1585                 1590             


Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser Ser Gln  Asp Gly His 
    1595                 1600                 1605             


Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys Val Lys  Val Phe Gln 
    1610                 1615                 1620             


Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val Asn Ser  Leu Asp Pro 
    1625                 1630                 1635             


Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His Pro Gln  Ser Trp Val 
    1640                 1645                 1650             


His Gln  Ile Ala Leu Arg Met  Glu Val Leu Gly Cys  Glu Ala Gln 
    1655                 1660                 1665             


Asp Leu  Tyr 
    1670     


<210>  49
<211>  1672
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  49

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Asp Lys Thr His Thr Cys Pro 
        755                 760                 765             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    770                 775                 780                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
785                 790                 795                 800 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                805                 810                 815     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            820                 825                 830         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        835                 840                 845             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    850                 855                 860                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
865                 870                 875                 880 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                885                 890                 895     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            900                 905                 910         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        915                 920                 925             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    930                 935                 940                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
945                 950                 955                 960 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                965                 970                 975     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Glu Ile Thr Arg 
            980                 985                 990         


Thr Thr Leu Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
        995                 1000                 1005             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1010                 1015                 1020             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1025                 1030                 1035             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1040                 1045                 1050             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1055                 1060                 1065             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1070                 1075                 1080             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1085                 1090                 1095             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1100                 1105                 1110             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1115                 1120                 1125             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1130                 1135                 1140             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1145                 1150                 1155             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1160                 1165                 1170             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1175                 1180                 1185             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1190                 1195                 1200             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1205                 1210                 1215             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1220                 1225                 1230             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1235                 1240                 1245             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1250                 1255                 1260             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1265                 1270                 1275             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1280                 1285                 1290             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1295                 1300                 1305             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1310                 1315                 1320             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1325                 1330                 1335             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    1340                 1345                 1350             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    1355                 1360                 1365             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    1370                 1375                 1380             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    1385                 1390                 1395             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    1400                 1405                 1410             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    1415                 1420                 1425             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    1430                 1435                 1440             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    1445                 1450                 1455             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    1460                 1465                 1470             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    1475                 1480                 1485             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    1490                 1495                 1500             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    1505                 1510                 1515             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    1520                 1525                 1530             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    1535                 1540                 1545             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    1550                 1555                 1560             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    1565                 1570                 1575             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    1580                 1585                 1590             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    1595                 1600                 1605             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    1610                 1615                 1620             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    1625                 1630                 1635             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    1640                 1645                 1650             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    1655                 1660                 1665             


Gln Asp  Leu Tyr 
    1670         


