                         SEQUENCE LISTING

<110>  UNIVERSITY HEALTH NETWORK
 
<120>  METHODS, COMPOUNDS AND COMPOSITIONS FOR MODULATING BLOOD BRAIN 
       BARRIER INTEGRITY AND RE-MYELINATION

<130>  05014971-177PCT

<140>  N/A
<141>  2016-09-22

<150>  US62/338,793
<151>  2016-05-19

<150>  US62/222,697
<151>  2015-09-23

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser Ser Thr Leu Ser 
1               5                   10                  15      


Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys Arg Ala Leu Arg 
        35                  40                  45              


Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp 
    50                  55                  60                  


Leu Ala Phe His Ser Ala Val His Gly Ile Glu Asp Leu Met Ile Gln 
65                  70                  75                  80  


His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro Pro Arg Gly 
                85                  90                  95      


Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala Pro Asp Pro Cys 
            100                 105                 110         


Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg Pro Pro Gly Phe 
        115                 120                 125             


Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg Ser Phe His His 
    130                 135                 140                 


His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu Leu Asp Asn 
145                 150                 155                 160 


Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala Leu Gly Ala 
                165                 170                 175     


Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys Asn Met Gln 
            180                 185                 190         


Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn Leu Pro 
        195                 200                 205             


Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro Gly Gly 
    210                 215                 220                 


Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val Glu Ile 
225                 230                 235                 240 


Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr Ala Gly 
                245                 250                 255     


Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala Met Ala Phe 
            260                 265                 270         


Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys Pro Pro Ser 
        275                 280                 285             


Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile Thr Ile 
    290                 295                 300                 


Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val Glu Asp Ala 
305                 310                 315                 320 


Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly Asp Pro Asn 
                325                 330                 335     


Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg Ala Phe Leu 
            340                 345                 350         


Pro Asp Leu Glu Lys Leu His 
        355                 


<210>  2
<211>  1077
<212>  DNA
<213>  Homo sapiens

<400>  2
tgcaagatcc tccgctgcaa tgctgagtac gtatcgtcca ctctgagcct tagaggtggg       60

ggttcatcag gagcacttcg aggaggagga ggaggaggcc ggggtggagg ggtgggctct      120

ggcggcctct gtcgagccct ccgctcctat gcgctctgca ctcggcgcac cgcccgcacc      180

tgccgcgggg acctcgcctt ccattcggcg gtacatggca tcgaagacct gatgatccag      240

cacaactgct cccgccaggg ccctacagcc cctcccccgc cccggggccc cgcccttcca      300

ggcgcgggct ccggcctccc tgccccggac ccttgtgact atgaaggccg gttttcccgg      360

ctgcatggtc gtcccccggg gttcttgcat tgcgcttcct tcggggaccc ccatgtgcgc      420

agcttccacc atcactttca cacatgccgt gtccaaggag cttggcctct actggataat      480

gacttcctct ttgtccaagc caccagctcc cccatggcgt tgggggccaa cgctaccgcc      540

acccggaagc tcaccatcat atttaagaac atgcaggaat gcattgatca gaaggtgtat      600

caggctgagg tggataatct tcctgtagcc tttgaagatg gttctatcaa tggaggtgac      660

cgacctgggg gatccagttt gtcgattcaa actgctaacc ctgggaacca tgtggagatc      720

caagctgcct acattggcac aactataatc attcggcaga cagctgggca gctctccttc      780

tccatcaagg tagcagagga tgtggccatg gccttctcag ctgaacagga cctgcagctc      840

tgtgttgggg ggtgccctcc aagtcagcga ctctctcgat cagagcgcaa tcgtcgggga      900

gctataacca ttgatactgc cagacggctg tgcaaggaag ggcttccagt ggaagatgct      960

tacttccatt cctgtgtctt tgatgtttta atttctggtg atcccaactt taccgtggca     1020

gctcaggcag cactggagga tgcccgagcc ttcctgccag acttagagaa gctgcat        1077


<210>  3
<211>  357
<212>  PRT
<213>  Mus musculus

<400>  3

Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser Ser Thr Leu Ser 
1               5                   10                  15      


Leu Arg Gly Gly Gly Ser Pro Asp Thr Pro Arg Gly Gly Gly Arg Gly 
            20                  25                  30          


Gly Leu Ala Ser Gly Gly Leu Cys Arg Ala Leu Arg Ser Tyr Ala Leu 
        35                  40                  45              


Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp Leu Ala Phe His 
    50                  55                  60                  


Ser Ala Val His Gly Ile Glu Asp Leu Met Ile Gln His Asn Cys Ser 
65                  70                  75                  80  


Arg Gln Gly Pro Thr Ala Pro Pro Pro Ala Arg Gly Pro Ala Leu Pro 
                85                  90                  95      


Gly Ala Gly Pro Ala Pro Leu Thr Pro Asp Pro Cys Asp Tyr Glu Ala 
            100                 105                 110         


Arg Phe Ser Arg Leu His Gly Arg Ala Pro Gly Phe Leu His Cys Ala 
        115                 120                 125             


Ser Phe Gly Asp Pro His Val Arg Ser Phe His Asn Gln Phe His Thr 
    130                 135                 140                 


Cys Arg Val Gln Gly Ala Trp Pro Leu Leu Asp Asn Asp Phe Leu Phe 
145                 150                 155                 160 


Val Gln Ala Thr Ser Ser Pro Val Ser Ser Gly Ala Asn Ala Thr Thr 
                165                 170                 175     


Ile Arg Lys Ile Thr Ile Ile Phe Lys Asn Met Gln Glu Cys Ile Asp 
            180                 185                 190         


Gln Lys Val Tyr Gln Ala Glu Val Asp Asn Leu Pro Ala Ala Phe Glu 
        195                 200                 205             


Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro Gly Gly Ser Ser Leu Ser 
    210                 215                 220                 


Ile Gln Thr Ala Asn Leu Gly Ser His Val Glu Ile Arg Ala Ala Tyr 
225                 230                 235                 240 


Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr Ala Gly Gln Leu Ser Phe 
                245                 250                 255     


Ser Ile Arg Val Ala Glu Asp Val Ala Arg Ala Phe Ser Ala Glu Gln 
            260                 265                 270         


Asp Leu Gln Leu Cys Val Gly Gly Cys Pro Pro Ser Gln Arg Leu Ser 
        275                 280                 285             


Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile Ala Ile Asp Thr Ala Arg 
    290                 295                 300                 


Arg Leu Cys Lys Glu Gly Leu Pro Val Glu Asp Ala Tyr Phe Gln Ser 
305                 310                 315                 320 


Cys Val Phe Asp Val Ser Val Ser Gly Asp Pro Asn Phe Thr Val Ala 
                325                 330                 335     


Ala Gln Thr Ala Leu Asp Asp Ala Arg Ile Phe Leu Thr Asp Leu Glu 
            340                 345                 350         


Asn Leu His Leu Phe 
        355         


<210>  4
<211>  1071
<212>  DNA
<213>  Mus musculus

<400>  4
tgcaagatcc tccgctgcaa tgccgagtat gtctcgtcca ctctgagtct tcggggaggt       60

ggctcaccgg acacgccgcg tggaggcggc cgtggtgggc tggcctcagg tggcttgtgt      120

cgcgccctgc gctcctacgc tctctgcacg cggcgcacgg cccgcacctg ccgcggggac      180

cttgctttcc actctgcggt gcatggcata gaggacctga tgatccagca caactgctca      240

cgccagggtc ccacggcccc gcccccggcc cggggccccg ccctgcccgg ggccgggcca      300

gcgcccctga ccccagatcc ctgtgactat gaggcccggt tttccaggct gcacggtcga      360

gccccgggct tcttgcattg cgcatccttt ggagatcccc atgtgcgcag tttccacaac      420

caatttcaca catgccgtgt ccaaggagct tggcccttgc tagataacga cttcctcttt      480

gtccaggcca ccagctcccc ggtttcgtcg ggagccaacg ctaccaccat ccggaagatc      540

actatcatat ttaaaaacat gcaggaatgc attgaccaga aagtctacca ggctgaggtg      600

gacaatcttc ctgcagcctt tgaagatggt tctatcaatg ggggcgaccg acctgggggc      660

tcgagtttgt ccattcaaac tgctaacctt gggagtcacg tggagattcg agctgcctac      720

attggaacaa ctatcatcat tcgacagaca gctgggcagc tctccttctc catcagggta      780

gcagaggatg tggcgcgggc cttctccgca gagcaggacc tacagctgtg tgttggggga      840

tgccctccga gccagcgact ctctcgctca gagcgcaacc gccgtggggc tatagccata      900

gatactgcca gaaggctgtg taaggaaggg cttccggttg aagatgccta cttccaatcc      960

tgcgtctttg atgtttcagt ctccggtgac cccaacttta ctgtggcagc tcagacagct     1020

ctggacgatg cccgaatctt cttgacggat ttagagaact tacatctctt t              1071


<210>  5
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  5
cttggtaccc atcatcatca tcatcatcag tgcaagatcc tccgctg                     47


<210>  6
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  6
gcgtctagac actcgagcgt cgagctgccc agctgtctgt c                           41


