                         SEQUENCE LISTING

<110>  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF 
       MILITARY  MEDICINE, INC.
       DVEKSLER, Gabriela
 
<120>  COMPOSITIONS COMPRISING PREGNANCY SPECIFIC GLYCOPROTEINS AND 
       METHODS OF USE THEREOF

<130>  044508-5059-WO

<150>  US 62/219,900
<151>  2015-09-17

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Thr Leu Ser Ala Pro Pro Cys Thr Gln Arg Ile Lys Trp Lys 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Leu Pro Thr 
            20                  25                  30          


Thr Ala Gln Val Thr Ile Glu Ala Glu Pro Thr Lys Val Ser Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Thr Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Gln Met Arg Asp Leu Tyr His Tyr Ile Thr 
65                  70                  75                  80  


Ser Tyr Val Val Asp Gly Glu Ile Ile Ile Tyr Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ala Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Arg Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Gly Asp 
        115                 120                 125             


Asp Gly Thr Arg Gly Val Thr Gly Arg Phe Thr Phe Thr Leu His Leu 
    130                 135                 140                 


Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu 
145                 150                 155                 160 


Thr Met Glu Ala Val Ser Leu Thr Cys Asp Pro Glu Thr Pro Asp Ala 
                165                 170                 175     


Ser Tyr Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr His Ser 
            180                 185                 190         


Leu Lys Leu Ser Glu Thr Asn Arg Thr Leu Phe Leu Leu Gly Val Thr 
        195                 200                 205             


Lys Tyr Thr Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser 
    210                 215                 220                 


Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys Leu Pro 
225                 230                 235                 240 


Lys Pro Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn Lys Asp 
                245                 250                 255     


Val Leu Asn Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile 
            260                 265                 270         


Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Val Lys Arg 
        275                 280                 285             


Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg Asn Glu 
    290                 295                 300                 


Thr Gly Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly Ile Arg 
305                 310                 315                 320 


Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Arg 
                325                 330                 335     


Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Val Leu Tyr Leu 
            340                 345                 350         


Ser Cys Ser Ala Asp Ser Asn Pro Pro Ala Gln Tyr Ser Trp Thr Ile 
        355                 360                 365             


Asn Glu Lys Phe Gln Leu Pro Gly Gln Lys Leu Phe Ile Arg His Ile 
    370                 375                 380                 


Thr Thr Lys His Ser Gly Leu Tyr Val Cys Ser Val Arg Asn Ser Ala 
385                 390                 395                 400 


Thr Gly Lys Glu Ser Ser Lys Ser Met Thr Val Glu Val Ser Asp Trp 
                405                 410                 415     


Thr Val Pro 
            


<210>  2
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Thr Ile Glu Ala Glu Pro Thr Lys Val Ser Glu Gly Lys Asp 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Thr Gly Tyr Ile 
            20                  25                  30          


Trp Tyr Lys Gly Gln Met Arg Asp Leu Tyr His Tyr Ile Thr Ser Tyr 
        35                  40                  45              


Val Val Asp Gly Glu Ile Ile Ile Tyr Gly Pro Ala Tyr Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ala Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Arg 
65                  70                  75                  80  


Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Gly Asp Asp Gly 
                85                  90                  95      


Thr Arg Gly Val Thr Gly Arg Phe Thr Phe Thr Leu His Leu Glu Thr 
            100                 105                 110         


Pro Lys Pro Ser Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu Thr Met 
        115                 120                 125             


Glu Ala Val Ser Leu Thr Cys Asp Pro Glu Thr Pro Asp Ala Ser Tyr 
    130                 135                 140                 


Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr His Ser Leu Lys 
145                 150                 155                 160 


Leu Ser Glu Thr Asn Arg Thr Leu Phe Leu Leu Gly Val Thr Lys Tyr 
                165                 170                 175     


Thr Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser Ala Ser 
            180                 185                 190         


Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys Leu Pro Lys Pro 
        195                 200                 205             


Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn Lys Asp Val Leu 
    210                 215                 220                 


Asn Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile Trp Trp 
225                 230                 235                 240 


Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Val Lys Arg Pro Ile 
                245                 250                 255     


Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg Asn Glu Thr Gly 
            260                 265                 270         


Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly Ile Arg Ser Asp 
        275                 280                 285             


Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Arg Ile Tyr 
    290                 295                 300                 


Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Val Leu Tyr Leu Ser Cys 
305                 310                 315                 320 


Ser Ala Asp Ser Asn Pro Pro Ala Gln Tyr Ser Trp Thr Ile Asn Glu 
                325                 330                 335     


Lys Phe Gln Leu Pro Gly Gln Lys Leu Phe Ile Arg His Ile Thr Thr 
            340                 345                 350         


Lys His Ser Gly Leu Tyr Val Cys Ser Val Arg Asn Ser Ala Thr Gly 
        355                 360                 365             


Lys Glu Ser Ser Lys Ser Met Thr Val Glu Val Ser Asp Trp Thr Val 
    370                 375                 380                 


Pro 
385 


<210>  3
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Pro Leu Pro Ala Pro Ser Cys Thr Gln Arg Ile Thr Trp Lys 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Glu Val Thr Ile Glu Ala Gln Pro Pro Lys Val Ser Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Pro Gly 
    50                  55                  60                  


Tyr Phe Trp Tyr Lys Gly Glu Met Thr Asp Leu Tyr His Tyr Ile Ile 
65                  70                  75                  80  


Ser Tyr Ile Val Asp Gly Lys Ile Ile Ile Tyr Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Arg Lys Asp Ala Gly Thr Tyr Thr Leu His Ile Ile Lys Arg Gly 
        115                 120                 125             


Asp Glu Thr Arg Glu Glu Ile Arg His Phe Thr Phe Thr Leu Tyr Leu 
    130                 135                 140                 


Glu Thr Pro Lys Pro Tyr Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu 
145                 150                 155                 160 


Ala Met Glu Ala Val Arg Leu Ile Cys Asp Pro Glu Thr Leu Asp Ala 
                165                 170                 175     


Ser Tyr Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Val Thr His Arg 
            180                 185                 190         


Leu Gln Leu Ser Lys Thr Asn Arg Thr Leu Tyr Leu Phe Gly Val Thr 
        195                 200                 205             


Lys Tyr Ile Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser 
    210                 215                 220                 


Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys Leu Pro 
225                 230                 235                 240 


Ile Pro Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn Lys Asp 
                245                 250                 255     


Val Leu Ala Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile 
            260                 265                 270         


Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Gly Val Lys Arg 
        275                 280                 285             


Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg Asn Glu 
    290                 295                 300                 


Thr Gly Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly Leu Arg 
305                 310                 315                 320 


Ser Asn Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Arg 
                325                 330                 335     


Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn Leu Asp Leu 
            340                 345                 350         


Ser Cys Phe Thr Glu Ser Asn Pro Pro Ala Glu Tyr Phe Trp Thr Ile 
        355                 360                 365             


Asn Gly Lys Phe Gln Gln Ser Gly Gln Lys Leu Phe Ile Pro Gln Ile 
    370                 375                 380                 


Thr Arg Asn His Ser Gly Leu Tyr Ala Cys Ser Val His Asn Ser Ala 
385                 390                 395                 400 


Thr Gly Lys Glu Ile Ser Lys Ser Met Thr Val Lys Val Ser Gly Pro 
                405                 410                 415     


Cys His Gly Asp Leu Thr Glu Ser Gln Ser 
            420                 425     


<210>  4
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Val Thr Ile Glu Ala Gln Pro Pro Lys Val Ser Glu Gly Lys Asp 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Pro Gly Tyr Phe 
            20                  25                  30          


Trp Tyr Lys Gly Glu Met Thr Asp Leu Tyr His Tyr Ile Ile Ser Tyr 
        35                  40                  45              


Ile Val Asp Gly Lys Ile Ile Ile Tyr Gly Pro Ala Tyr Ser Gly Arg 
    50                  55                  60                  


Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Arg 
65                  70                  75                  80  


Lys Asp Ala Gly Thr Tyr Thr Leu His Ile Ile Lys Arg Gly Asp Glu 
                85                  90                  95      


Thr Arg Glu Glu Ile Arg His Phe Thr Phe Thr Leu Tyr Leu Glu Thr 
            100                 105                 110         


Pro Lys Pro Tyr Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu Ala Met 
        115                 120                 125             


Glu Ala Val Arg Leu Ile Cys Asp Pro Glu Thr Leu Asp Ala Ser Tyr 
    130                 135                 140                 


Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Val Thr His Arg Leu Gln 
145                 150                 155                 160 


Leu Ser Lys Thr Asn Arg Thr Leu Tyr Leu Phe Gly Val Thr Lys Tyr 
                165                 170                 175     


Ile Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser Ala Ser 
            180                 185                 190         


Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys Leu Pro Ile Pro 
        195                 200                 205             


Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn Lys Asp Val Leu 
    210                 215                 220                 


Ala Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile Trp Trp 
225                 230                 235                 240 


Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Gly Val Lys Arg Pro Ile 
                245                 250                 255     


Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg Asn Glu Thr Gly 
            260                 265                 270         


Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly Leu Arg Ser Asn 
        275                 280                 285             


Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Arg Ile Tyr 
    290                 295                 300                 


Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn Leu Asp Leu Ser Cys 
305                 310                 315                 320 


Phe Thr Glu Ser Asn Pro Pro Ala Glu Tyr Phe Trp Thr Ile Asn Gly 
                325                 330                 335     


Lys Phe Gln Gln Ser Gly Gln Lys Leu Phe Ile Pro Gln Ile Thr Arg 
            340                 345                 350         


Asn His Ser Gly Leu Tyr Ala Cys Ser Val His Asn Ser Ala Thr Gly 
        355                 360                 365             


Lys Glu Ile Ser Lys Ser Met Thr Val Lys Val Ser Gly Pro Cys His 
    370                 375                 380                 


Gly Asp Leu Thr Glu Ser Gln Ser 
385                 390         


