                         SEQUENCE LISTING

<110>  Institute for Cancer Research d/b/a The Research Institute 
       of Fox Chase Cancer Center
 
<120>  Systems and MEthods for Treating Patients Having a Genetic 
       Predisposition to Develop Prostate Cancer

<130>  185300-3113

<160>  100   

<170>  PatentIn version 3.5

<210>  1
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln Arg 
1               5                   10                  15      


Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro Glu 
            20                  25                  30          


Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Gln Leu Lys 
        35                  40                  45              


Ala Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln Val Gly Val Asn 
    50                  55                  60                  


Pro Thr Ser Ile Asp Ser Val Val Ile Gly Lys Asp Gln Glu Val Lys 
65                  70                  75                  80  


Leu Gln Pro Gly Gln Val Leu His Met Val Asn Glu Leu Tyr Pro Tyr 
                85                  90                  95      


Ile Val Glu Phe Glu Glu Glu Ala Lys Asn Pro Gly Leu Glu Thr His 
            100                 105                 110         


Arg Lys Arg Lys Arg Ser Gly Asn Ser Asp Ser Ile Glu Arg Asp Ala 
        115                 120                 125             


Ala Gln Glu Ala Glu Ala Gly Thr Gly Leu Glu Pro Gly Ser Asn Ser 
    130                 135                 140                 


Gly Gln Cys Ser Val Pro Leu Lys Lys Gly Lys Asp Ala Pro Ile Lys 
145                 150                 155                 160 


Lys Glu Ser Leu Gly His Trp Ser Gln Gly Leu Lys Ile Ser Met Gln 
                165                 170                 175     


Asp Pro Lys Met Gln Val Tyr Lys Asp Glu Gln Val Val Val Ile Lys 
            180                 185                 190         


Asp Lys Tyr Pro Lys Ala Arg Tyr His Trp Leu Val Leu Pro Trp Thr 
        195                 200                 205             


Ser Ile Ser Ser Leu Lys Ala Val Ala Arg Glu His Leu Glu Leu Leu 
    210                 215                 220                 


Lys His Met His Thr Val Gly Glu Lys Val Ile Val Asp Phe Ala Gly 
225                 230                 235                 240 


Ser Ser Lys Leu Arg Phe Arg Leu Gly Tyr His Ala Ile Pro Ser Met 
                245                 250                 255     


Ser His Val His Leu His Val Ile Ser Gln Asp Phe Asp Ser Pro Cys 
            260                 265                 270         


Leu Lys Asn Lys Lys His Trp Asn Ser Phe Asn Thr Glu Tyr Phe Leu 
        275                 280                 285             


Glu Ser Gln Ala Val Ile Glu Met Val Gln Glu Ala Gly Arg Val Thr 
    290                 295                 300                 


Val Arg Asp Gly Met Pro Glu Leu Leu Lys Leu Pro Leu Arg Cys His 
305                 310                 315                 320 


Glu Cys Gln Gln Leu Leu Pro Ser Ile Pro Gln Leu Lys Glu His Leu 
                325                 330                 335     


Arg Lys His Trp Thr Gln 
            340         


<210>  2
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  3
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Glu Gly Pro Gly Cys Thr Leu Asn Gly Glu Lys Ile Arg Ala 
1               5                   10                  15      


Arg Val Leu Pro Gly Gln Ala Val Thr Gly Val Arg Gly Ser Ala Leu 
            20                  25                  30          


Arg Ser Leu Gln Gly Arg Ala Leu Arg Leu Ala Ala Ser Thr Val Val 
        35                  40                  45              


Val Ser Pro Gln Ala Ala Ala Leu Asn Asn Asp Ser Ser Gln Asn Val 
    50                  55                  60                  


Leu Ser Leu Phe Asn Gly Tyr Val Tyr Ser Gly Val Glu Thr Leu Gly 
65                  70                  75                  80  


Lys Glu Leu Phe Met Tyr Phe Gly Pro Lys Ala Leu Arg Ile His Phe 
                85                  90                  95      


Gly Met Lys Gly Phe Ile Met Ile Asn Pro Leu Glu Tyr Lys Tyr Lys 
            100                 105                 110         


Asn Gly Ala Ser Pro Val Leu Glu Val Gln Leu Thr Lys Asp Leu Ile 
        115                 120                 125             


Cys Phe Phe Asp Ser Ser Val Glu Leu Arg Asn Ser Met Glu Ser Gln 
    130                 135                 140                 


Gln Arg Ile Arg Met Met Lys Glu Leu Asp Val Cys Ser Pro Glu Phe 
145                 150                 155                 160 


Ser Phe Leu Arg Ala Glu Ser Glu Val Lys Lys Gln Lys Gly Arg Met 
                165                 170                 175     


Leu Gly Asp Val Leu Met Asp Gln Asn Val Leu Pro Gly Val Gly Asn 
            180                 185                 190         


Ile Ile Lys Asn Glu Ala Leu Phe Asp Ser Gly Leu His Pro Ala Val 
        195                 200                 205             


Lys Val Cys Gln Leu Thr Asp Glu Gln Ile His His Leu Met Lys Met 
    210                 215                 220                 


Ile Arg Asp Phe Ser Ile Leu Phe Tyr Arg Cys Arg Lys Ala Gly Leu 
225                 230                 235                 240 


Ala Leu Ser Lys His Tyr Lys Val Tyr Lys Arg Pro Asn Cys Gly Gln 
                245                 250                 255     


Cys His Cys Arg Ile Thr Val Cys Arg Phe Gly Asp Asn Asn Arg Met 
            260                 265                 270         


Thr Tyr Phe Cys Pro His Cys Gln Lys Glu Asn Pro Gln His Val Asp 
        275                 280                 285             


Ile Cys Lys Leu Pro Thr Arg Asn Thr Ile Ile Ser Trp Thr Ser Ser 
    290                 295                 300                 


Arg Val Asp His Val Met Asp Ser Val Ala Arg Lys Ser Glu Glu His 
305                 310                 315                 320 


Trp Thr Cys Val Val Cys Thr Leu Ile Asn Lys Pro Ser Ser Lys Ala 
                325                 330                 335     


Cys Asp Ala Cys Leu Thr Ser Arg Pro Ile Asp Ser Val Leu Lys Ser 
            340                 345                 350         


Glu Glu Asn Ser Thr Val Phe Ser His Leu Met Lys Tyr Pro Cys Asn 
        355                 360                 365             


Thr Phe Gly Lys Pro His Thr Glu Val Lys Ile Asn Arg Lys Thr Ala 
    370                 375                 380                 


Phe Gly Thr Thr Thr Leu Val Leu Thr Asp Phe Ser Asn Lys Ser Ser 
385                 390                 395                 400 


Thr Leu Glu Arg Lys Thr Lys Gln Asn Gln Ile Leu Asp Glu Glu Phe 
                405                 410                 415     


Gln Asn Ser Pro Pro Ala Ser Val Cys Leu Asn Asp Ile Gln His Pro 
            420                 425                 430         


Ser Lys Lys Thr Thr Asn Asp Ile Thr Gln Pro Ser Ser Lys Val Asn 
        435                 440                 445             


Ile Ser Pro Thr Ile Ser Ser Glu Ser Lys Leu Phe Ser Pro Ala His 
    450                 455                 460                 


Lys Lys Pro Lys Thr Ala Gln Tyr Ser Ser Pro Glu Leu Lys Ser Cys 
465                 470                 475                 480 


Asn Pro Gly Tyr Ser Asn Ser Glu Leu Gln Ile Asn Met Thr Asp Gly 
                485                 490                 495     


Pro Arg Thr Leu Asn Pro Asp Ser Pro Arg Cys Ser Lys His Asn Arg 
            500                 505                 510         


Leu Cys Ile Leu Arg Val Val Arg Lys Asp Gly Glu Asn Lys Gly Arg 
        515                 520                 525             


Gln Phe Tyr Ala Cys Pro Leu Pro Arg Glu Ala Gln Cys Gly Phe Phe 
    530                 535                 540                 


Glu Trp Ala Asp Leu Ser Phe Pro Phe Cys Asn His Gly Lys Arg Ser 
545                 550                 555                 560 


Thr Met Lys Thr Val Leu Lys Ile Gly Pro Asn Asn Gly Lys Asn Phe 
                565                 570                 575     


Phe Val Cys Pro Leu Gly Lys Glu Lys Gln Cys Asn Phe Phe Gln Trp 
            580                 585                 590         


Ala Glu Asn Gly Pro Gly Ile Lys Ile Ile Pro Gly Cys 
        595                 600                 605 


<210>  4
<211>  1501
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Cys Lys Met Ala Ile Ile Pro Asp Trp Leu Arg Ser His Pro His 
1               5                   10                  15      


Thr Arg Lys Phe Thr His Ser Arg Pro His Ser Ser Pro Cys Arg Val 
            20                  25                  30          


Tyr Ser Arg Asn Gly Ser Pro Asn Lys Phe Arg Ser Ser Ser Thr Thr 
        35                  40                  45              


Ala Val Ala Asn Pro Thr Leu Ser Ser Leu Asp Val Lys Arg Ile Leu 
    50                  55                  60                  


Phe Gln Lys Ile Thr Asp Arg Gly Asp Glu Leu Gln Lys Ala Phe Gln 
65                  70                  75                  80  


Leu Leu Asp Thr Gly Gln Asn Leu Thr Val Ser Lys Ser Glu Leu Arg 
                85                  90                  95      


Arg Ile Ile Thr Asp Phe Leu Met Pro Leu Thr Arg Glu Gln Phe Gln 
            100                 105                 110         


Asp Val Leu Ala Gln Ile Pro Leu Ser Thr Ser Gly Thr Val Pro Tyr 
        115                 120                 125             


Leu Ala Phe Leu Ser Arg Phe Gly Gly Ile Asp Leu Tyr Ile Asn Gly 
    130                 135                 140                 


Ile Lys Arg Gly Gly Gly Asn Glu Met Asn Cys Cys Arg Thr Leu Arg 
145                 150                 155                 160 


Glu Leu Glu Ile Gln Val Gly Glu Lys Val Phe Lys Asn Ile Lys Thr 
                165                 170                 175     


Val Met Lys Ala Phe Glu Leu Ile Asp Val Asn Lys Thr Gly Leu Val 
            180                 185                 190         


Arg Pro Gln Glu Leu Arg Arg Val Leu Glu Thr Phe Cys Met Lys Leu 
        195                 200                 205             


Arg Asp Glu Glu Tyr Glu Lys Phe Ser Lys His Tyr Asn Ile His Lys 
    210                 215                 220                 


Asp Thr Ala Val Asp Tyr Asn Val Phe Leu Lys Asn Leu Ser Ile Asn 
225                 230                 235                 240 


Asn Asp Leu Asn Leu Arg Tyr Cys Met Gly Asn Gln Glu Val Ser Leu 
                245                 250                 255     


Glu Asn Gln Gln Ala Lys Asn Ser Lys Lys Glu Arg Leu Leu Gly Ser 
            260                 265                 270         


Ala Ser Ser Glu Asp Ile Trp Arg Asn Tyr Ser Leu Asp Glu Ile Glu 
        275                 280                 285             


Arg Asn Phe Cys Leu Gln Leu Ser Lys Ser Tyr Glu Lys Val Glu Lys 
    290                 295                 300                 


Ala Leu Ser Ala Gly Asp Pro Cys Lys Gly Gly Tyr Val Ser Phe Asn 
305                 310                 315                 320 


Tyr Leu Lys Ile Val Leu Asp Thr Phe Val Tyr Gln Ile Pro Arg Arg 
                325                 330                 335     


Ile Phe Ile Gln Leu Met Lys Arg Phe Gly Leu Lys Ala Thr Thr Lys 
            340                 345                 350         


Ile Asn Trp Lys Gln Phe Leu Thr Ser Phe His Glu Pro Gln Gly Leu 
        355                 360                 365             


Gln Val Ser Ser Lys Gly Pro Leu Thr Lys Arg Asn Ser Ile Asn Ser 
    370                 375                 380                 


Arg Asn Glu Ser His Lys Glu Asn Ile Ile Thr Lys Leu Phe Arg His 
385                 390                 395                 400 


Thr Glu Asp His Ser Ala Ser Leu Lys Lys Ala Leu Leu Ile Ile Asn 
                405                 410                 415     


Thr Lys Pro Asp Gly Pro Ile Thr Arg Glu Glu Phe Arg Tyr Ile Leu 
            420                 425                 430         


Asn Cys Met Ala Val Lys Leu Ser Asp Ser Glu Phe Lys Glu Leu Met 
        435                 440                 445             


Gln Met Leu Asp Pro Gly Asp Thr Gly Val Val Asn Thr Ser Met Phe 
    450                 455                 460                 


Ile Asp Leu Ile Glu Glu Asn Cys Arg Met Arg Lys Thr Ser Pro Cys 
465                 470                 475                 480 


Thr Asp Ala Lys Thr Pro Phe Leu Leu Ala Trp Asp Ser Val Glu Glu 
                485                 490                 495     


Ile Val His Asp Thr Ile Thr Arg Asn Leu Gln Ala Phe Tyr Asn Met 
            500                 505                 510         


Leu Arg Ser Tyr Asp Leu Gly Asp Thr Gly Arg Ile Gly Arg Asn Asn 
        515                 520                 525             


Phe Lys Lys Ile Met His Val Phe Cys Pro Phe Leu Thr Asn Ala His 
    530                 535                 540                 


Phe Ile Lys Leu Cys Ser Lys Ile Gln Asp Ile Gly Ser Gly Arg Ile 
545                 550                 555                 560 


Leu Tyr Lys Lys Leu Leu Ala Cys Ile Gly Ile Asp Gly Pro Pro Thr 
                565                 570                 575     


Val Ser Pro Val Leu Val Pro Lys Asp Gln Leu Leu Ser Glu His Leu 
            580                 585                 590         


Gln Lys Asp Glu Gln Gln Gln Pro Asp Leu Ser Glu Arg Thr Lys Leu 
        595                 600                 605             


Thr Glu Asp Lys Thr Thr Leu Thr Lys Lys Met Thr Thr Glu Glu Val 
    610                 615                 620                 


Ile Glu Lys Phe Lys Lys Cys Ile Gln Gln Gln Asp Pro Ala Phe Lys 
625                 630                 635                 640 


Lys Arg Phe Leu Asp Phe Ser Lys Glu Pro Asn Gly Lys Ile Asn Val 
                645                 650                 655     


His Asp Phe Lys Lys Val Leu Glu Asp Thr Gly Met Pro Met Asp Asp 
            660                 665                 670         


Asp Gln Tyr Ala Leu Leu Thr Thr Lys Ile Gly Phe Glu Lys Glu Gly 
        675                 680                 685             


Met Ser Tyr Leu Asp Phe Ala Ala Gly Phe Glu Asp Pro Pro Met Arg 
    690                 695                 700                 


Gly Pro Glu Thr Thr Pro Pro Gln Pro Pro Thr Pro Ser Lys Ser Tyr 
705                 710                 715                 720 


Val Asn Ser His Phe Ile Thr Ala Glu Glu Cys Leu Lys Leu Phe Pro 
                725                 730                 735     


Arg Arg Leu Lys Glu Ser Phe Arg Asp Pro Tyr Ser Ala Phe Phe Lys 
            740                 745                 750         


Thr Asp Ala Asp Arg Asp Gly Ile Ile Asn Met His Asp Leu His Arg 
        755                 760                 765             


Leu Leu Leu His Leu Leu Leu Asn Leu Lys Asp Asp Glu Phe Glu Arg 
    770                 775                 780                 


Phe Leu Gly Leu Leu Gly Leu Arg Leu Ser Val Thr Leu Asn Phe Arg 
785                 790                 795                 800 


Glu Phe Gln Asn Leu Cys Glu Lys Arg Pro Trp Arg Thr Asp Glu Ala 
                805                 810                 815     


Pro Gln Arg Leu Ile Arg Pro Lys Gln Lys Val Ala Asp Ser Glu Leu 
            820                 825                 830         


Ala Cys Glu Gln Ala His Gln Tyr Leu Val Thr Lys Ala Lys Asn Arg 
        835                 840                 845             


Trp Ser Asp Leu Ser Lys Asn Phe Leu Glu Thr Asp Asn Glu Gly Asn 
    850                 855                 860                 


Gly Ile Leu Arg Arg Arg Asp Ile Lys Asn Ala Leu Tyr Gly Phe Asp 
865                 870                 875                 880 


Ile Pro Leu Thr Pro Arg Glu Phe Glu Lys Leu Trp Ala Arg Tyr Asp 
                885                 890                 895     


Thr Glu Gly Lys Gly His Ile Thr Tyr Gln Glu Phe Leu Gln Lys Leu 
            900                 905                 910         


Gly Ile Asn Tyr Ser Pro Ala Val His Arg Pro Cys Ala Glu Asp Tyr 
        915                 920                 925             


Phe Asn Phe Met Gly His Phe Thr Lys Pro Gln Gln Leu Gln Glu Glu 
    930                 935                 940                 


Met Lys Glu Leu Gln Gln Ser Thr Glu Lys Ala Val Ala Ala Arg Asp 
945                 950                 955                 960 


Lys Leu Met Asp Arg His Gln Asp Ile Ser Lys Ala Phe Thr Lys Thr 
                965                 970                 975     


Asp Gln Ser Lys Thr Asn Tyr Ile Ser Ile Cys Lys Met Gln Glu Val 
            980                 985                 990         


Leu Glu Glu Cys Gly Cys Ser Leu  Thr Glu Gly Glu Leu  Thr His Leu 
        995                 1000                 1005             


Leu Asn  Ser Trp Gly Val Ser  Arg His Asp Asn Ala  Ile Asn Tyr 
    1010                 1015                 1020             


Leu Asp  Phe Leu Arg Ala Val  Glu Asn Ser Lys Ser  Thr Gly Ala 
    1025                 1030                 1035             


Gln Pro  Lys Glu Lys Glu Glu  Ser Met Pro Ile Asn  Phe Ala Thr 
    1040                 1045                 1050             


Leu Asn  Pro Gln Glu Ala Val  Arg Lys Ile Gln Glu  Val Val Glu 
    1055                 1060                 1065             


Ser Ser  Gln Leu Ala Leu Ser  Thr Ala Phe Ser Ala  Leu Asp Lys 
    1070                 1075                 1080             


Glu Asp  Thr Gly Phe Val Lys  Ala Thr Glu Phe Gly  Gln Val Leu 
    1085                 1090                 1095             


Lys Asp  Phe Cys Tyr Lys Leu  Thr Asp Asn Gln Tyr  His Tyr Phe 
    1100                 1105                 1110             


Leu Arg  Lys Leu Arg Ile His  Leu Thr Pro Tyr Ile  Asn Trp Lys 
    1115                 1120                 1125             


Tyr Phe  Leu Gln Asn Phe Ser  Cys Phe Leu Glu Glu  Thr Ala Asp 
    1130                 1135                 1140             


Glu Trp  Ala Glu Lys Met Pro  Lys Gly Pro Pro Pro  Thr Ser Pro 
    1145                 1150                 1155             


Lys Ala  Thr Ala Asp Arg Asp  Ile Leu Ala Arg Leu  His Lys Ala 
    1160                 1165                 1170             


Val Thr  Ser His Tyr His Ala  Ile Thr Gln Glu Phe  Glu Asn Phe 
    1175                 1180                 1185             


Asp Thr  Met Lys Thr Asn Thr  Ile Ser Arg Glu Glu  Phe Arg Ala 
    1190                 1195                 1200             


Ile Cys  Asn Arg Arg Val Gln  Ile Leu Thr Asp Glu  Gln Phe Asp 
    1205                 1210                 1215             


Arg Leu  Trp Asn Glu Met Pro  Val Asn Ala Lys Gly  Arg Leu Lys 
    1220                 1225                 1230             


Tyr Pro  Asp Phe Leu Ser Arg  Phe Ser Ser Glu Thr  Ala Ala Thr 
    1235                 1240                 1245             


Pro Met  Ala Thr Gly Asp Ser  Ala Val Ala Gln Arg  Gly Ser Ser 
    1250                 1255                 1260             


Val Pro  Asp Val Ser Glu Gly  Thr Arg Ser Ala Leu  Ser Leu Pro 
    1265                 1270                 1275             


Thr Gln  Glu Leu Arg Pro Gly  Ser Lys Ser Gln Ser  His Pro Cys 
    1280                 1285                 1290             


Thr Pro  Ala Ser Thr Thr Val  Ile Pro Gly Thr Pro  Pro Leu Gln 
    1295                 1300                 1305             


Asn Cys  Asp Pro Ile Glu Ser  Arg Leu Arg Lys Arg  Ile Gln Gly 
    1310                 1315                 1320             


Cys Trp  Arg Gln Leu Leu Lys  Glu Cys Lys Glu Lys  Asp Val Ala 
    1325                 1330                 1335             


Arg Gln  Gly Asp Ile Asn Ala  Ser Asp Phe Leu Ala  Leu Val Glu 
    1340                 1345                 1350             


Lys Phe  Asn Leu Asp Ile Ser  Lys Glu Glu Cys Gln  Gln Leu Ile 
    1355                 1360                 1365             


Ile Lys  Tyr Asp Leu Lys Ser  Asn Gly Lys Phe Ala  Tyr Cys Asp 
    1370                 1375                 1380             


Phe Ile  Gln Ser Cys Val Leu  Leu Leu Lys Ala Lys  Glu Ser Ser 
    1385                 1390                 1395             


Leu Met  His Arg Met Lys Ile  Gln Asn Ala His Lys  Met Lys Glu 
    1400                 1405                 1410             


Ala Gly  Ala Glu Thr Pro Ser  Phe Tyr Ser Ala Leu  Leu Arg Ile 
    1415                 1420                 1425             


Gln Pro  Lys Ile Val His Cys  Trp Arg Pro Met Arg  Arg Thr Phe 
    1430                 1435                 1440             


Lys Ser  Tyr Asp Glu Ala Gly  Thr Gly Leu Leu Ser  Val Ala Asp 
    1445                 1450                 1455             


Phe Arg  Thr Val Leu Arg Gln  Tyr Ser Ile Asn Leu  Ser Glu Glu 
    1460                 1465                 1470             


Glu Phe  Phe His Ile Leu Glu  Tyr Tyr Asp Lys Thr  Leu Ser Ser 
    1475                 1480                 1485             


Lys Ile  Ser Tyr Asn Asp Phe  Leu Arg Ala Phe Leu  Gln 
    1490                 1495                 1500     


<210>  5
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  6
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Gly Ile Lys Lys Gln Lys Thr Glu Asn Gln Gln Lys Ser Thr 
1               5                   10                  15      


Asn Val Val Tyr Gln Ala His His Val Ser Arg Asn Lys Arg Gly Gln 
            20                  25                  30          


Val Val Gly Thr Arg Gly Gly Phe Arg Gly Cys Thr Val Trp Leu Thr 
        35                  40                  45              


Gly Leu Ser Gly Ala Gly Lys Thr Thr Ile Ser Phe Ala Leu Glu Glu 
    50                  55                  60                  


Tyr Leu Val Ser His Ala Ile Pro Cys Tyr Ser Leu Asp Gly Asp Asn 
65                  70                  75                  80  


Val Arg His Gly Leu Asn Arg Asn Leu Gly Phe Ser Pro Gly Asp Arg 
                85                  90                  95      


Glu Glu Asn Ile Arg Arg Ile Ala Glu Val Ala Lys Leu Phe Ala Asp 
            100                 105                 110         


Ala Gly Leu Val Cys Ile Thr Ser Phe Ile Ser Pro Phe Ala Lys Asp 
        115                 120                 125             


Arg Glu Asn Ala Arg Lys Ile His Glu Ser Ala Gly Leu Pro Phe Phe 
    130                 135                 140                 


Glu Ile Phe Val Asp Ala Pro Leu Asn Ile Cys Glu Ser Arg Asp Val 
145                 150                 155                 160 


Lys Gly Leu Tyr Lys Arg Ala Arg Ala Gly Glu Ile Lys Gly Phe Thr 
                165                 170                 175     


Gly Ile Asp Ser Asp Tyr Glu Lys Pro Glu Thr Pro Glu Arg Val Leu 
            180                 185                 190         


Lys Thr Asn Leu Ser Thr Val Ser Asp Cys Val His Gln Val Val Glu 
        195                 200                 205             


Leu Leu Gln Glu Gln Asn Ile Val Pro Tyr Thr Ile Ile Lys Asp Ile 
    210                 215                 220                 


His Glu Leu Phe Val Pro Glu Asn Lys Leu Asp His Val Arg Ala Glu 
225                 230                 235                 240 


Ala Glu Thr Leu Pro Ser Leu Ser Ile Thr Lys Leu Asp Leu Gln Trp 
                245                 250                 255     


Val Gln Val Leu Ser Glu Gly Trp Ala Thr Pro Leu Lys Gly Phe Met 
            260                 265                 270         


Arg Glu Lys Glu Tyr Leu Gln Val Met His Phe Asp Thr Leu Leu Asp 
        275                 280                 285             


Asp Gly Val Ile Asn Met Ser Ile Pro Ile Val Leu Pro Val Ser Ala 
    290                 295                 300                 


Glu Asp Lys Thr Arg Leu Glu Gly Cys Ser Lys Phe Val Leu Ala His 
305                 310                 315                 320 


Gly Gly Arg Arg Val Ala Ile Leu Arg Asp Ala Glu Phe Tyr Glu His 
                325                 330                 335     


Arg Lys Glu Glu Arg Cys Ser Arg Val Trp Gly Thr Thr Cys Thr Lys 
            340                 345                 350         


His Pro His Ile Lys Met Val Met Glu Ser Gly Asp Trp Leu Val Gly 
        355                 360                 365             


Gly Asp Leu Gln Val Leu Glu Lys Ile Arg Trp Asn Asp Gly Leu Asp 
    370                 375                 380                 


Gln Tyr Arg Leu Thr Pro Leu Glu Leu Lys Gln Lys Cys Lys Glu Met 
385                 390                 395                 400 


Asn Ala Asp Ala Val Phe Ala Phe Gln Leu Arg Asn Pro Val His Asn 
                405                 410                 415     


Gly His Ala Leu Leu Met Gln Asp Thr Arg Arg Arg Leu Leu Glu Arg 
            420                 425                 430         


Gly Tyr Lys His Pro Val Leu Leu Leu His Pro Leu Gly Gly Trp Thr 
        435                 440                 445             


Lys Asp Asp Asp Val Pro Leu Asp Trp Arg Met Lys Gln His Ala Ala 
    450                 455                 460                 


Val Leu Glu Glu Gly Val Leu Asp Pro Lys Ser Thr Ile Val Ala Ile 
465                 470                 475                 480 


Phe Pro Ser Pro Met Leu Tyr Ala Gly Pro Thr Glu Val Gln Trp His 
                485                 490                 495     


Cys Arg Ser Arg Met Ile Ala Gly Ala Asn Phe Tyr Ile Val Gly Arg 
            500                 505                 510         


Asp Pro Ala Gly Met Pro His Pro Glu Thr Lys Lys Asp Leu Tyr Glu 
        515                 520                 525             


Pro Thr His Gly Gly Lys Val Leu Ser Met Ala Pro Gly Leu Thr Ser 
    530                 535                 540                 


Val Glu Ile Ile Pro Phe Arg Val Ala Ala Tyr Asn Lys Ala Lys Lys 
545                 550                 555                 560 


Ala Met Asp Phe Tyr Asp Pro Ala Arg His Asn Glu Phe Asp Phe Ile 
                565                 570                 575     


Ser Gly Thr Arg Met Arg Lys Leu Ala Arg Glu Gly Glu Asn Pro Pro 
            580                 585                 590         


Asp Gly Phe Met Ala Pro Lys Ala Trp Lys Val Leu Thr Asp Tyr Tyr 
        595                 600                 605             


Arg Ser Leu Glu Lys Asn 
    610                 


<210>  7
<211>  1164
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Gln Gln Ala Asn Val Gly Glu Leu Leu Ala Met Leu Asp Ser 
1               5                   10                  15      


Pro Met Leu Gly Val Arg Asp Asp Val Thr Ala Val Phe Lys Glu Asn 
            20                  25                  30          


Leu Asn Ser Asp Arg Gly Pro Met Leu Val Asn Thr Leu Val Asp Tyr 
        35                  40                  45              


Tyr Leu Glu Thr Ser Ser Gln Pro Ala Leu His Ile Leu Thr Thr Leu 
    50                  55                  60                  


Gln Glu Pro His Asp Lys His Leu Leu Asp Arg Ile Asn Glu Tyr Val 
65                  70                  75                  80  


Gly Lys Ala Ala Thr Arg Leu Ser Ile Leu Ser Leu Leu Gly His Val 
                85                  90                  95      


Ile Arg Leu Gln Pro Ser Trp Lys His Lys Leu Ser Gln Ala Pro Leu 
            100                 105                 110         


Leu Pro Ser Leu Leu Lys Cys Leu Lys Met Asp Thr Asp Val Val Val 
        115                 120                 125             


Leu Thr Thr Gly Val Leu Val Leu Ile Thr Met Leu Pro Met Ile Pro 
    130                 135                 140                 


Gln Ser Gly Lys Gln His Leu Leu Asp Phe Phe Asp Ile Phe Gly Arg 
145                 150                 155                 160 


Leu Ser Ser Trp Cys Leu Lys Lys Pro Gly His Val Ala Glu Val Tyr 
                165                 170                 175     


Leu Val His Leu His Ala Ser Val Tyr Ala Leu Phe His Arg Leu Tyr 
            180                 185                 190         


Gly Met Tyr Pro Cys Asn Phe Val Ser Phe Leu Arg Ser His Tyr Ser 
        195                 200                 205             


Met Lys Glu Asn Leu Glu Thr Phe Glu Glu Val Val Lys Pro Met Met 
    210                 215                 220                 


Glu His Val Arg Ile His Pro Glu Leu Val Thr Gly Ser Lys Asp His 
225                 230                 235                 240 


Glu Leu Asp Pro Arg Arg Trp Lys Arg Leu Glu Thr His Asp Val Val 
                245                 250                 255     


Ile Glu Cys Ala Lys Ile Ser Leu Asp Pro Thr Glu Ala Ser Tyr Glu 
            260                 265                 270         


Asp Gly Tyr Ser Val Ser His Gln Ile Ser Ala Arg Phe Pro His Arg 
        275                 280                 285             


Ser Ala Asp Val Thr Thr Ser Pro Tyr Ala Asp Thr Gln Asn Ser Tyr 
    290                 295                 300                 


Gly Cys Ala Thr Ser Thr Pro Tyr Ser Thr Ser Arg Leu Met Leu Leu 
305                 310                 315                 320 


Asn Met Pro Gly Gln Leu Pro Gln Thr Leu Ser Ser Pro Ser Thr Arg 
                325                 330                 335     


Leu Ile Thr Glu Pro Pro Gln Ala Thr Leu Trp Ser Pro Ser Met Val 
            340                 345                 350         


Cys Gly Met Thr Thr Pro Pro Thr Ser Pro Gly Asn Val Pro Pro Asp 
        355                 360                 365             


Leu Ser His Pro Tyr Ser Lys Val Phe Gly Thr Thr Ala Gly Gly Lys 
    370                 375                 380                 


Gly Thr Pro Leu Gly Thr Pro Ala Thr Ser Pro Pro Pro Ala Pro Leu 
385                 390                 395                 400 


Cys His Ser Asp Asp Tyr Val His Ile Ser Leu Pro Gln Ala Thr Val 
                405                 410                 415     


Thr Pro Pro Arg Lys Glu Glu Arg Met Asp Ser Ala Arg Pro Cys Leu 
            420                 425                 430         


His Arg Gln His His Leu Leu Asn Asp Arg Gly Ser Glu Glu Pro Pro 
        435                 440                 445             


Gly Ser Lys Gly Ser Val Thr Leu Ser Asp Leu Pro Gly Phe Leu Gly 
    450                 455                 460                 


Asp Leu Ala Ser Glu Glu Asp Ser Ile Glu Lys Asp Lys Glu Glu Ala 
465                 470                 475                 480 


Ala Ile Ser Arg Glu Leu Ser Glu Ile Thr Thr Ala Glu Ala Glu Pro 
                485                 490                 495     


Val Val Pro Arg Gly Gly Phe Asp Ser Pro Phe Tyr Arg Asp Ser Leu 
            500                 505                 510         


Pro Gly Ser Gln Arg Lys Thr His Ser Ala Ala Ser Ser Ser Gln Gly 
        515                 520                 525             


Ala Ser Val Asn Pro Glu Pro Leu His Ser Ser Leu Asp Lys Leu Gly 
    530                 535                 540                 


Pro Asp Thr Pro Lys Gln Ala Phe Thr Pro Ile Asp Leu Pro Cys Gly 
545                 550                 555                 560 


Ser Ala Asp Glu Ser Pro Ala Gly Asp Arg Glu Cys Gln Thr Ser Leu 
                565                 570                 575     


Glu Thr Ser Ile Phe Thr Pro Ser Pro Cys Lys Ile Pro Pro Pro Thr 
            580                 585                 590         


Arg Val Gly Phe Gly Ser Gly Gln Pro Pro Pro Tyr Asp His Leu Phe 
        595                 600                 605             


Glu Val Ala Leu Pro Lys Thr Ala His His Phe Val Ile Arg Lys Thr 
    610                 615                 620                 


Glu Glu Leu Leu Lys Lys Ala Lys Gly Asn Thr Glu Glu Asp Gly Val 
625                 630                 635                 640 


Pro Ser Thr Ser Pro Met Glu Val Leu Asp Arg Leu Ile Gln Gln Gly 
                645                 650                 655     


Ala Asp Ala His Ser Lys Glu Leu Asn Lys Leu Pro Leu Pro Ser Lys 
            660                 665                 670         


Ser Val Asp Trp Thr His Phe Gly Gly Ser Pro Pro Ser Asp Glu Ile 
        675                 680                 685             


Arg Thr Leu Arg Asp Gln Leu Leu Leu Leu His Asn Gln Leu Leu Tyr 
    690                 695                 700                 


Glu Arg Phe Lys Arg Gln Gln His Ala Leu Arg Asn Arg Arg Leu Leu 
705                 710                 715                 720 


Arg Lys Val Ile Lys Ala Ala Ala Leu Glu Glu His Asn Ala Ala Met 
                725                 730                 735     


Lys Asp Gln Leu Lys Leu Gln Glu Lys Asp Ile Gln Met Trp Lys Val 
            740                 745                 750         


Ser Leu Gln Lys Glu Gln Ala Arg Tyr Asn Gln Leu Gln Glu Gln Arg 
        755                 760                 765             


Asp Thr Met Val Thr Lys Leu His Ser Gln Ile Arg Gln Leu Gln His 
    770                 775                 780                 


Asp Arg Glu Glu Phe Tyr Asn Gln Ser Gln Glu Leu Gln Thr Lys Leu 
785                 790                 795                 800 


Glu Asp Cys Arg Asn Met Ile Ala Glu Leu Arg Ile Glu Leu Lys Lys 
                805                 810                 815     


Ala Asn Asn Lys Val Cys His Thr Glu Leu Leu Leu Ser Gln Val Ser 
            820                 825                 830         


Gln Lys Leu Ser Asn Ser Glu Ser Val Gln Gln Gln Met Glu Phe Leu 
        835                 840                 845             


Asn Arg Gln Leu Leu Val Leu Gly Glu Val Asn Glu Leu Tyr Leu Glu 
    850                 855                 860                 


Gln Leu Gln Asn Lys His Ser Asp Thr Thr Lys Glu Val Glu Met Met 
865                 870                 875                 880 


Lys Ala Ala Tyr Arg Lys Glu Leu Glu Lys Asn Arg Ser His Val Leu 
                885                 890                 895     


Gln Gln Thr Gln Arg Leu Asp Thr Ser Gln Lys Arg Ile Leu Glu Leu 
            900                 905                 910         


Glu Ser His Leu Ala Lys Lys Asp His Leu Leu Leu Glu Gln Lys Lys 
        915                 920                 925             


Tyr Leu Glu Asp Val Lys Leu Gln Ala Arg Gly Gln Leu Gln Ala Ala 
    930                 935                 940                 


Glu Ser Arg Tyr Glu Ala Gln Lys Arg Ile Thr Gln Val Phe Glu Leu 
945                 950                 955                 960 


Glu Ile Leu Asp Leu Tyr Gly Arg Leu Glu Lys Asp Gly Leu Leu Lys 
                965                 970                 975     


Lys Leu Glu Glu Glu Lys Ala Glu Ala Ala Glu Ala Ala Glu Glu Arg 
            980                 985                 990         


Leu Asp Cys Cys Asn Asp Gly Cys  Ser Asp Ser Met Val  Gly His Asn 
        995                 1000                 1005             


Glu Glu  Ala Ser Gly His Asn  Gly Glu Thr Lys Thr  Pro Arg Pro 
    1010                 1015                 1020             


Ser Ser  Ala Arg Gly Ser Ser  Gly Ser Arg Gly Gly  Gly Gly Ser 
    1025                 1030                 1035             


Ser Ser  Ser Ser Ser Glu Leu  Ser Thr Pro Glu Lys  Pro Pro His 
    1040                 1045                 1050             


Gln Arg  Ala Gly Pro Phe Ser  Ser Arg Trp Glu Thr  Thr Met Gly 
    1055                 1060                 1065             


Glu Ala  Ser Ala Ser Ile Pro  Thr Thr Val Gly Ser  Leu Pro Ser 
    1070                 1075                 1080             


Ser Lys  Ser Phe Leu Gly Met  Lys Ala Arg Glu Leu  Phe Arg Asn 
    1085                 1090                 1095             


Lys Ser  Glu Ser Gln Cys Asp  Glu Asp Gly Met Thr  Ser Ser Leu 
    1100                 1105                 1110             


Ser Glu  Ser Leu Lys Thr Glu  Leu Gly Lys Asp Leu  Gly Val Glu 
    1115                 1120                 1125             


Ala Lys  Ile Pro Leu Asn Leu  Asp Gly Pro His Pro  Ser Pro Pro 
    1130                 1135                 1140             


Thr Pro  Asp Ser Val Gly Gln  Leu His Ile Met Asp  Tyr Asn Glu 
    1145                 1150                 1155             


Thr His  His Glu His Ser 
    1160                 


<210>  8
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Ala Leu Thr Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu Cys 
1               5                   10                  15      


Ile Ala Gly Gln Ala Gly Ala Lys Pro Ser Gly Ala Glu Ser Ser Lys 
            20                  25                  30          


Gly Ala Ala Phe Val Ser Lys Gln Glu Gly Ser Glu Val Val Lys Arg 
        35                  40                  45              


Pro Arg Arg Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro 
    50                  55                  60                  


Asp Pro Leu Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys 
65                  70                  75                  80  


Asp Glu Leu Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe 
                85                  90                  95      


Tyr Gly Pro Val 
            100 


<210>  9
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Val Thr Glu Ala Ser Leu Leu Arg Gln Cys Pro Leu Leu Leu 
1               5                   10                  15      


Pro Gln Asn Arg Ser Lys Thr Val Tyr Glu Gly Phe Ile Ser Ala Gln 
            20                  25                  30          


Gly Arg Asp Phe His Leu Arg Ile Val Leu Pro Glu Asp Leu Gln Leu 
        35                  40                  45              


Lys Asn Ala Arg Leu Leu Cys Ser Trp Gln Leu Arg Thr Ile Leu Ser 
    50                  55                  60                  


Gly Tyr His Arg Ile Val Gln Gln Arg Met Gln His Ser Pro Asp Leu 
65                  70                  75                  80  


Met Ser Phe Met Met Glu Leu Lys Met Leu Leu Glu Val Ala Leu Lys 
                85                  90                  95      


Asn Arg Gln Glu Leu Tyr Ala Leu Pro Pro Pro Pro Gln Phe Tyr Ser 
            100                 105                 110         


Ser Leu Ile Glu Glu Ile Gly Thr Leu Gly Trp Asp Lys Leu Val Tyr 
        115                 120                 125             


Ala Asp Thr Cys Phe Ser Thr Ile Lys Leu Lys Ala Glu Asp Ala Ser 
    130                 135                 140                 


Gly Arg Glu His Leu Ile Thr Leu Lys Leu Lys Ala Lys Tyr Pro Ala 
145                 150                 155                 160 


Glu Ser Pro Asp Tyr Phe Val Asp Phe Pro Val Pro Phe Cys Ala Ser 
                165                 170                 175     


Trp Thr Pro Gln Ser Ser Leu Ile Ser Ile Tyr Ser Gln Phe Leu Ala 
            180                 185                 190         


Ala Ile Glu Ser Leu Lys Ala Phe Trp Asp Val Met Asp Glu Ile Asp 
        195                 200                 205             


Glu Lys Thr Trp Val Leu Glu Pro Glu Lys Pro Pro Arg Ser Ala Thr 
    210                 215                 220                 


Ala Arg Arg Ile Ala Leu Gly Asn Asn Val Ser Ile Asn Ile Glu Val 
225                 230                 235                 240 


Asp Pro Arg His Pro Thr Met Leu Pro Glu Cys Phe Phe Leu Gly Ala 
                245                 250                 255     


Asp His Val Val Lys Pro Leu Gly Ile Lys Leu Ser Arg Asn Ile His 
            260                 265                 270         


Leu Trp Asp Pro Glu Asn Ser Val Leu Gln Asn Leu Lys Asp Val Leu 
        275                 280                 285             


Glu Ile Asp Phe Pro Ala Arg Ala Ile Leu Glu Lys Ser Asp Phe Thr 
    290                 295                 300                 


Met Asp Cys Gly Ile Cys Tyr Ala Tyr Gln Leu Asp Gly Thr Ile Pro 
305                 310                 315                 320 


Asp Gln Val Cys Asp Asn Ser Gln Cys Gly Gln Pro Phe His Gln Ile 
                325                 330                 335     


Cys Leu Tyr Glu Trp Leu Arg Gly Leu Leu Thr Ser Arg Gln Ser Phe 
            340                 345                 350         


Asn Ile Ile Phe Gly Glu Cys Pro Tyr Cys Ser Lys Pro Ile Thr Leu 
        355                 360                 365             


Lys Met Ser Gly Arg Lys His 
    370                 375 


<210>  10
<211>  1137
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Arg Arg Lys Pro Ala Ser Gly Gly Leu Ala Ala Ser Ser Ser 
1               5                   10                  15      


Ala Pro Ala Arg Gln Ala Val Leu Ser Arg Phe Phe Gln Ser Thr Gly 
            20                  25                  30          


Ser Leu Lys Ser Thr Ser Ser Ser Thr Gly Ala Ala Asp Gln Val Asp 
        35                  40                  45              


Pro Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Pro Pro 
    50                  55                  60                  


Ala Pro Pro Ala Pro Ala Phe Pro Pro Gln Leu Pro Pro His Ile Ala 
65                  70                  75                  80  


Thr Glu Ile Asp Arg Arg Lys Lys Arg Pro Leu Glu Asn Asp Gly Pro 
                85                  90                  95      


Val Lys Lys Lys Val Lys Lys Val Gln Gln Lys Glu Gly Gly Ser Asp 
            100                 105                 110         


Leu Gly Met Ser Gly Asn Ser Glu Pro Lys Lys Cys Leu Arg Thr Arg 
        115                 120                 125             


Asn Val Ser Lys Ser Leu Glu Lys Leu Lys Glu Phe Cys Cys Asp Ser 
    130                 135                 140                 


Ala Leu Pro Gln Ser Arg Val Gln Thr Glu Ser Leu Gln Glu Arg Phe 
145                 150                 155                 160 


Ala Val Leu Pro Lys Cys Thr Asp Phe Asp Asp Ile Ser Leu Leu His 
                165                 170                 175     


Ala Lys Asn Ala Val Ser Ser Glu Asp Ser Lys Arg Gln Ile Asn Gln 
            180                 185                 190         


Lys Asp Thr Thr Leu Phe Asp Leu Ser Gln Phe Gly Ser Ser Asn Thr 
        195                 200                 205             


Ser His Glu Asn Leu Gln Lys Thr Ala Ser Lys Ser Ala Asn Lys Arg 
    210                 215                 220                 


Ser Lys Ser Ile Tyr Thr Pro Leu Glu Leu Gln Tyr Ile Glu Met Lys 
225                 230                 235                 240 


Gln Gln His Lys Asp Ala Val Leu Cys Val Glu Cys Gly Tyr Lys Tyr 
                245                 250                 255     


Arg Phe Phe Gly Glu Asp Ala Glu Ile Ala Ala Arg Glu Leu Asn Ile 
            260                 265                 270         


Tyr Cys His Leu Asp His Asn Phe Met Thr Ala Ser Ile Pro Thr His 
        275                 280                 285             


Arg Leu Phe Val His Val Arg Arg Leu Val Ala Lys Gly Tyr Lys Val 
    290                 295                 300                 


Gly Val Val Lys Gln Thr Glu Thr Ala Ala Leu Lys Ala Ile Gly Asp 
305                 310                 315                 320 


Asn Arg Ser Ser Leu Phe Ser Arg Lys Leu Thr Ala Leu Tyr Thr Lys 
                325                 330                 335     


Ser Thr Leu Ile Gly Glu Asp Val Asn Pro Leu Ile Lys Leu Asp Asp 
            340                 345                 350         


Ala Val Asn Val Asp Glu Ile Met Thr Asp Thr Ser Thr Ser Tyr Leu 
        355                 360                 365             


Leu Cys Ile Ser Glu Asn Lys Glu Asn Val Arg Asp Lys Lys Lys Gly 
    370                 375                 380                 


Asn Ile Phe Ile Gly Ile Val Gly Val Gln Pro Ala Thr Gly Glu Val 
385                 390                 395                 400 


Val Phe Asp Ser Phe Gln Asp Ser Ala Ser Arg Ser Glu Leu Glu Thr 
                405                 410                 415     


Arg Met Ser Ser Leu Gln Pro Val Glu Leu Leu Leu Pro Ser Ala Leu 
            420                 425                 430         


Ser Glu Gln Thr Glu Ala Leu Ile His Arg Ala Thr Ser Val Ser Val 
        435                 440                 445             


Gln Asp Asp Arg Ile Arg Val Glu Arg Met Asp Asn Ile Tyr Phe Glu 
    450                 455                 460                 


Tyr Ser His Ala Phe Gln Ala Val Thr Glu Phe Tyr Ala Lys Asp Thr 
465                 470                 475                 480 


Val Asp Ile Lys Gly Ser Gln Ile Ile Ser Gly Ile Val Asn Leu Glu 
                485                 490                 495     


Lys Pro Val Ile Cys Ser Leu Ala Ala Ile Ile Lys Tyr Leu Lys Glu 
            500                 505                 510         


Phe Asn Leu Glu Lys Met Leu Ser Lys Pro Glu Asn Phe Lys Gln Leu 
        515                 520                 525             


Ser Ser Lys Met Glu Phe Met Thr Ile Asn Gly Thr Thr Leu Arg Asn 
    530                 535                 540                 


Leu Glu Ile Leu Gln Asn Gln Thr Asp Met Lys Thr Lys Gly Ser Leu 
545                 550                 555                 560 


Leu Trp Val Leu Asp His Thr Lys Thr Ser Phe Gly Arg Arg Lys Leu 
                565                 570                 575     


Lys Lys Trp Val Thr Gln Pro Leu Leu Lys Leu Arg Glu Ile Asn Ala 
            580                 585                 590         


Arg Leu Asp Ala Val Ser Glu Val Leu His Ser Glu Ser Ser Val Phe 
        595                 600                 605             


Gly Gln Ile Glu Asn His Leu Arg Lys Leu Pro Asp Ile Glu Arg Gly 
    610                 615                 620                 


Leu Cys Ser Ile Tyr His Lys Lys Cys Ser Thr Gln Glu Phe Phe Leu 
625                 630                 635                 640 


Ile Val Lys Thr Leu Tyr His Leu Lys Ser Glu Phe Gln Ala Ile Ile 
                645                 650                 655     


Pro Ala Val Asn Ser His Ile Gln Ser Asp Leu Leu Arg Thr Val Ile 
            660                 665                 670         


Leu Glu Ile Pro Glu Leu Leu Ser Pro Val Glu His Tyr Leu Lys Ile 
        675                 680                 685             


Leu Asn Glu Gln Ala Ala Lys Val Gly Asp Lys Thr Glu Leu Phe Lys 
    690                 695                 700                 


Asp Leu Ser Asp Phe Pro Leu Ile Lys Lys Arg Lys Asp Glu Ile Gln 
705                 710                 715                 720 


Gly Val Ile Asp Glu Ile Arg Met His Leu Gln Glu Ile Arg Lys Ile 
                725                 730                 735     


Leu Lys Asn Pro Ser Ala Gln Tyr Val Thr Val Ser Gly Gln Glu Phe 
            740                 745                 750         


Met Ile Glu Ile Lys Asn Ser Ala Val Ser Cys Ile Pro Thr Asp Trp 
        755                 760                 765             


Val Lys Val Gly Ser Thr Lys Ala Val Ser Arg Phe His Ser Pro Phe 
    770                 775                 780                 


Ile Val Glu Asn Tyr Arg His Leu Asn Gln Leu Arg Glu Gln Leu Val 
785                 790                 795                 800 


Leu Asp Cys Ser Ala Glu Trp Leu Asp Phe Leu Glu Lys Phe Ser Glu 
                805                 810                 815     


His Tyr His Ser Leu Cys Lys Ala Val His His Leu Ala Thr Val Asp 
            820                 825                 830         


Cys Ile Phe Ser Leu Ala Lys Val Ala Lys Gln Gly Asp Tyr Cys Arg 
        835                 840                 845             


Pro Thr Val Gln Glu Glu Arg Lys Ile Val Ile Lys Asn Gly Arg His 
    850                 855                 860                 


Pro Val Ile Asp Val Leu Leu Gly Glu Gln Asp Gln Tyr Val Pro Asn 
865                 870                 875                 880 


Asn Thr Asp Leu Ser Glu Asp Ser Glu Arg Val Met Ile Ile Thr Gly 
                885                 890                 895     


Pro Asn Met Gly Gly Lys Ser Ser Tyr Ile Lys Gln Val Ala Leu Ile 
            900                 905                 910         


Thr Ile Met Ala Gln Ile Gly Ser Tyr Val Pro Ala Glu Glu Ala Thr 
        915                 920                 925             


Ile Gly Ile Val Asp Gly Ile Phe Thr Arg Met Gly Ala Ala Asp Asn 
    930                 935                 940                 


Ile Tyr Lys Gly Gln Ser Thr Phe Met Glu Glu Leu Thr Asp Thr Ala 
945                 950                 955                 960 


Glu Ile Ile Arg Lys Ala Thr Ser Gln Ser Leu Val Ile Leu Asp Glu 
                965                 970                 975     


Leu Gly Arg Gly Thr Ser Thr His Asp Gly Ile Ala Ile Ala Tyr Ala 
            980                 985                 990         


Thr Leu Glu Tyr Phe Ile Arg Asp  Val Lys Ser Leu Thr  Leu Phe Val 
        995                 1000                 1005             


Thr His  Tyr Pro Pro Val Cys  Glu Leu Glu Lys Asn  Tyr Ser His 
    1010                 1015                 1020             


Gln Val  Gly Asn Tyr His Met  Gly Phe Leu Val Ser  Glu Asp Glu 
    1025                 1030                 1035             


Ser Lys  Leu Asp Pro Gly Ala  Ala Glu Gln Val Pro  Asp Phe Val 
    1040                 1045                 1050             


Thr Phe  Leu Tyr Gln Ile Thr  Arg Gly Ile Ala Ala  Arg Ser Tyr 
    1055                 1060                 1065             


Gly Leu  Asn Val Ala Lys Leu  Ala Asp Val Pro Gly  Glu Ile Leu 
    1070                 1075                 1080             


Lys Lys  Ala Ala His Lys Ser  Lys Glu Leu Glu Gly  Leu Ile Asn 
    1085                 1090                 1095             


Thr Lys  Arg Lys Arg Leu Lys  Tyr Phe Ala Lys Leu  Trp Thr Met 
    1100                 1105                 1110             


His Asn  Ala Gln Asp Leu Gln  Lys Trp Thr Glu Glu  Phe Asn Met 
    1115                 1120                 1125             


Glu Glu  Thr Gln Thr Ser Leu  Leu His 
    1130                 1135         


<210>  11
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Ser Leu Phe Arg Ser Glu Thr Met Cys Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Gly Thr Ala Tyr Glu Cys Leu Ser Ala Leu Gly Glu Lys 
            20                  25                  30          


Gly Leu Val Gln Phe Arg Asp Leu Asn Gln Asn Val Ser Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Gly Glu Val Lys Arg Cys Glu Glu Leu Glu Arg Ile 
    50                  55                  60                  


Leu Val Tyr Leu Val Gln Glu Ile Asn Arg Ala Asp Ile Pro Leu Pro 
65                  70                  75                  80  


Glu Gly Glu Ala Ser Pro Pro Ala Pro Pro Leu Lys Gln Val Leu Glu 
                85                  90                  95      


Met Gln Glu Gln Leu Gln Lys Leu Glu Val Glu Leu Arg Glu Val Thr 
            100                 105                 110         


Lys Asn Lys Glu Lys Leu Arg Lys Asn Leu Leu Glu Leu Ile Glu Tyr 
        115                 120                 125             


Thr His Met Leu Arg Val Thr Lys Thr Phe Val Lys Arg Asn Val Glu 
    130                 135                 140                 


Phe Glu Pro Thr Tyr Glu Glu Phe Pro Ser Leu Glu Ser Asp Ser Leu 
145                 150                 155                 160 


Leu Asp Tyr Ser Cys Met Gln Arg Leu Gly Ala Lys Leu Gly Phe Val 
                165                 170                 175     


Ser Gly Leu Ile Asn Gln Gly Lys Val Glu Ala Phe Glu Lys Met Leu 
            180                 185                 190         


Trp Arg Val Cys Lys Gly Tyr Thr Ile Val Ser Tyr Ala Glu Leu Asp 
        195                 200                 205             


Glu Ser Leu Glu Asp Pro Glu Thr Gly Glu Val Ile Lys Trp Tyr Val 
    210                 215                 220                 


Phe Leu Ile Ser Phe Trp Gly Glu Gln Ile Gly His Lys Val Lys Lys 
225                 230                 235                 240 


Ile Cys Asp Cys Tyr His Cys His Val Tyr Pro Tyr Pro Asn Thr Ala 
                245                 250                 255     


Glu Glu Arg Arg Glu Ile Gln Glu Gly Leu Asn Thr Arg Ile Gln Asp 
            260                 265                 270         


Leu Tyr Thr Val Leu His Lys Thr Glu Asp Tyr Leu Arg Gln Val Leu 
        275                 280                 285             


Cys Lys Ala Ala Glu Ser Val Tyr Ser Arg Val Ile Gln Val Lys Lys 
    290                 295                 300                 


Met Lys Ala Ile Tyr His Met Leu Asn Met Cys Ser Phe Asp Val Thr 
305                 310                 315                 320 


Asn Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Glu Ala Asp Leu Gln 
                325                 330                 335     


Asp Leu Arg Arg Ala Leu Glu Glu Gly Ser Arg Glu Ser Gly Ala Thr 
            340                 345                 350         


Ile Pro Ser Phe Met Asn Ile Ile Pro Thr Lys Glu Thr Pro Pro Thr 
        355                 360                 365             


Arg Ile Arg Thr Asn Lys Phe Thr Glu Gly Phe Gln Asn Ile Val Asp 
    370                 375                 380                 


Ala Tyr Gly Val Gly Ser Tyr Arg Glu Val Asn Pro Ala Leu Phe Thr 
385                 390                 395                 400 


Ile Ile Thr Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly 
                405                 410                 415     


His Gly Phe Val Met Phe Leu Phe Ala Leu Leu Leu Val Leu Asn Glu 
            420                 425                 430         


Asn His Pro Arg Leu Asn Gln Ser Gln Glu Ile Met Arg Met Phe Phe 
        435                 440                 445             


Asn Gly Arg Tyr Ile Leu Leu Leu Met Gly Leu Phe Ser Val Tyr Thr 
    450                 455                 460                 


Gly Leu Ile Tyr Asn Asp Cys Phe Ser Lys Ser Val Asn Leu Phe Gly 
465                 470                 475                 480 


Ser Gly Trp Asn Val Ser Ala Met Tyr Ser Ser Ser His Pro Pro Ala 
                485                 490                 495     


Glu His Lys Lys Met Val Leu Trp Asn Asp Ser Val Val Arg His Asn 
            500                 505                 510         


Ser Ile Leu Gln Leu Asp Pro Ser Ile Pro Gly Val Phe Arg Gly Pro 
        515                 520                 525             


Tyr Pro Leu Gly Ile Asp Pro Ile Trp Asn Leu Ala Thr Asn Arg Leu 
    530                 535                 540                 


Thr Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly Ile 
545                 550                 555                 560 


Ile His Met Thr Phe Gly Val Ile Leu Gly Ile Phe Asn His Leu His 
                565                 570                 575     


Phe Arg Lys Lys Phe Asn Ile Tyr Leu Val Ser Ile Pro Glu Leu Leu 
            580                 585                 590         


Phe Met Leu Cys Ile Phe Gly Tyr Leu Ile Phe Met Ile Phe Tyr Lys 
        595                 600                 605             


Trp Leu Val Phe Ser Ala Glu Thr Ser Arg Val Ala Pro Ser Ile Leu 
    610                 615                 620                 


Ile Glu Phe Ile Asn Met Phe Leu Phe Pro Ala Ser Lys Thr Ser Gly 
625                 630                 635                 640 


Leu Tyr Thr Gly Gln Glu Tyr Val Gln Arg Val Leu Leu Val Val Thr 
                645                 650                 655     


Ala Leu Ser Val Pro Val Leu Phe Leu Gly Lys Pro Leu Phe Leu Leu 
            660                 665                 670         


Trp Leu His Asn Gly Arg Ser Cys Phe Gly Val Asn Arg Ser Gly Tyr 
        675                 680                 685             


Thr Leu Ile Arg Lys Asp Ser Glu Glu Glu Val Ser Leu Leu Gly Ser 
    690                 695                 700                 


Gln Asp Ile Glu Glu Gly Asn His Gln Val Glu Asp Gly Cys Arg Glu 
705                 710                 715                 720 


Met Ala Cys Glu Glu Phe Asn Phe Gly Glu Ile Leu Met Thr Gln Val 
                725                 730                 735     


Ile His Ser Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Thr Ala Ser 
            740                 745                 750         


Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Asp 
        755                 760                 765             


Val Leu Trp Ala Met Leu Met Arg Val Gly Leu Arg Val Asp Thr Thr 
    770                 775                 780                 


Tyr Gly Val Leu Leu Leu Leu Pro Val Ile Ala Leu Phe Ala Val Leu 
785                 790                 795                 800 


Thr Ile Phe Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His 
                805                 810                 815     


Ala Ile Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Val Gly 
            820                 825                 830         


Ala Gly Thr Lys Phe Val Pro Phe Ser Phe Ser Leu Leu Ser Ser Lys 
        835                 840                 845             


Phe Asn Asn Asp Asp Ser Val Ala 
    850                 855     


<210>  12
<211>  1467
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Asp Glu Ser Ala Ser Gly Ser Asp Pro Asp Leu Asp Pro Asp 
1               5                   10                  15      


Val Glu Leu Glu Asp Ala Glu Glu Glu Glu Glu Glu Glu Glu Val Ala 
            20                  25                  30          


Val Glu Glu Cys Asp Arg Asp Asp Glu Glu Asp Leu Leu Asp Asp Pro 
        35                  40                  45              


Ser Leu Glu Gly Met Cys Gly Thr Glu His Ala Gln Leu Gly Glu Asp 
    50                  55                  60                  


Gly Gln Gln Pro Pro Arg Cys Thr Ser Thr Thr Ser Ser Gln Ser Glu 
65                  70                  75                  80  


Pro Ser Glu Gln Leu Arg Arg His Gln Gly Lys Asn Leu Ala Ser Glu 
                85                  90                  95      


Asp Pro Lys Lys Lys Arg Ala Gln Lys Pro Ser His Met Arg Arg Asn 
            100                 105                 110         


Ile Arg Lys Leu Leu Arg Glu Asp Gln Leu Glu Pro Val Thr Lys Ala 
        115                 120                 125             


Ala Gln Gln Glu Glu Leu Glu Arg Arg Lys Arg Leu Glu Gln Gln Arg 
    130                 135                 140                 


Lys Asp Tyr Ala Ala Pro Ile Pro Thr Val Pro Leu Glu Phe Leu Pro 
145                 150                 155                 160 


Glu Glu Ile Ala Leu Arg Ala Ser Asp Gly Pro Gln Leu Pro Pro Arg 
                165                 170                 175     


Val Leu Ala Gln Glu Val Ile Cys Leu Asp Ser Ser Ser Gly Ser Glu 
            180                 185                 190         


Asp Glu Lys Ser Ser Arg Asp Glu Val Ile Glu Leu Ser Ser Gly Glu 
        195                 200                 205             


Glu Asp Thr Leu His Ile Val Asp Ser Ser Glu Ser Val Ser Glu Asp 
    210                 215                 220                 


Asp Glu Glu Glu Glu Lys Gly Gly Thr His Val Asn Asp Val Leu Asn 
225                 230                 235                 240 


Gln Arg Asp Ala Leu Gly Arg Val Leu Val Asn Leu Asn His Pro Pro 
                245                 250                 255     


Glu Glu Glu Asn Val Phe Leu Ala Pro Gln Leu Ala Arg Ala Val Lys 
            260                 265                 270         


Pro His Gln Ile Gly Gly Ile Arg Phe Leu Tyr Asp Asn Leu Val Glu 
        275                 280                 285             


Ser Leu Glu Arg Phe Lys Thr Ser Ser Gly Phe Gly Cys Ile Leu Ala 
    290                 295                 300                 


His Ser Met Gly Leu Gly Lys Thr Leu Gln Val Ile Ser Phe Ile Asp 
305                 310                 315                 320 


Val Leu Phe Arg His Thr Pro Ala Lys Thr Val Leu Ala Ile Val Pro 
                325                 330                 335     


Val Asn Thr Leu Gln Asn Trp Leu Ala Glu Phe Asn Met Trp Leu Pro 
            340                 345                 350         


Pro Pro Glu Ala Leu Pro Ala Asp Asn Lys Pro Glu Glu Val Gln Pro 
        355                 360                 365             


Arg Phe Phe Lys Val His Ile Leu Asn Asp Glu His Lys Thr Met Ala 
    370                 375                 380                 


Ser Arg Ala Lys Val Met Ala Asp Trp Val Ser Glu Gly Gly Val Leu 
385                 390                 395                 400 


Leu Met Gly Tyr Glu Met Tyr Arg Leu Leu Thr Leu Lys Lys Ser Phe 
                405                 410                 415     


Ala Thr Gly Arg Pro Lys Lys Thr Lys Lys Arg Ser His Pro Val Ile 
            420                 425                 430         


Ile Asp Leu Asp Glu Glu Asp Arg Gln Gln Glu Phe Arg Arg Glu Phe 
        435                 440                 445             


Glu Lys Ala Leu Cys Arg Pro Gly Pro Asp Val Val Ile Cys Asp Glu 
    450                 455                 460                 


Gly His Arg Ile Lys Asn Cys Gln Ala Ser Thr Ser Gln Ala Leu Lys 
465                 470                 475                 480 


Asn Ile Arg Ser Arg Arg Arg Val Val Leu Thr Gly Tyr Pro Leu Gln 
                485                 490                 495     


Asn Asn Leu Ile Glu Tyr Trp Cys Met Val Asp Phe Val Arg Pro Asp 
            500                 505                 510         


Phe Leu Gly Thr Arg Gln Glu Phe Ser Asn Met Phe Glu Arg Pro Ile 
        515                 520                 525             


Leu Asn Gly Gln Cys Ile Asp Ser Thr Pro Gln Asp Val Arg Leu Met 
    530                 535                 540                 


Arg Tyr Arg Ser His Val Leu His Ser Leu Leu Glu Gly Phe Val Gln 
545                 550                 555                 560 


Arg Arg Gly His Thr Val Leu Lys Ile His Leu Pro Ala Lys Glu Glu 
                565                 570                 575     


Asn Val Ile Leu Val Arg Leu Ser Lys Ile Gln Arg Asp Leu Tyr Thr 
            580                 585                 590         


Gln Phe Met Asp Arg Phe Arg Asp Cys Gly Ser Ser Gly Trp Leu Gly 
        595                 600                 605             


Leu Asn Pro Leu Lys Ala Phe Cys Val Cys Cys Lys Ile Trp Asn His 
    610                 615                 620                 


Pro Asp Val Leu Tyr Glu Ala Leu Gln Lys Glu Ser Leu Ala Asn Glu 
625                 630                 635                 640 


Gln Asp Leu Asp Val Glu Glu Leu Gly Ser Ala Gly Thr Ser Ala Arg 
                645                 650                 655     


Cys Pro Pro Gln Gly Thr Lys Gly Lys Gly Glu Asp Ser Thr Leu Ala 
            660                 665                 670         


Ser Ser Met Gly Glu Ala Thr Asn Ser Lys Phe Leu Gln Gly Val Gly 
        675                 680                 685             


Phe Asn Pro Phe Gln Glu Arg Gly Asn Asn Ile Val Thr Tyr Glu Trp 
    690                 695                 700                 


Ala Lys Asp Leu Leu Thr Asn Tyr Gln Thr Gly Val Leu Glu Asn Ser 
705                 710                 715                 720 


Pro Lys Met Val Leu Leu Phe His Leu Ile Glu Glu Ser Val Lys Leu 
                725                 730                 735     


Gly Asp Lys Ile Leu Val Phe Ser Gln Ser Leu Ser Thr Leu Ala Leu 
            740                 745                 750         


Ile Glu Glu Phe Leu Gly Lys Arg Glu Val Pro Cys Pro Pro Gly Thr 
        755                 760                 765             


Glu Gly Gln Gly Ala Gln Lys Trp Val Arg Asn Ile Ser Tyr Phe Arg 
    770                 775                 780                 


Leu Asp Gly Ser Thr Pro Ala Phe Glu Arg Glu Arg Leu Ile Asn Gln 
785                 790                 795                 800 


Phe Asn Asp Pro Ser Asn Leu Thr Thr Trp Leu Phe Leu Leu Ser Thr 
                805                 810                 815     


Arg Ala Gly Cys Leu Gly Val Asn Leu Ile Gly Ala Asn Arg Val Val 
            820                 825                 830         


Val Phe Asp Ala Ser Trp Asn Pro Cys His Asp Ala Gln Ala Val Cys 
        835                 840                 845             


Arg Val Tyr Arg Tyr Gly Gln Lys Lys Pro Cys Tyr Ile Tyr Arg Leu 
    850                 855                 860                 


Val Ala Asp Tyr Thr Leu Glu Lys Lys Ile Tyr Asp Arg Gln Ile Ser 
865                 870                 875                 880 


Lys Gln Gly Met Ser Asp Arg Val Val Asp Asp Leu Asn Pro Met Leu 
                885                 890                 895     


Asn Phe Thr Arg Lys Glu Val Glu Asn Leu Leu His Phe Val Glu Lys 
            900                 905                 910         


Glu Pro Ala Pro Gln Val Ser Leu Asn Val Lys Gly Ile Lys Glu Ser 
        915                 920                 925             


Val Leu Gln Leu Ala Cys Leu Lys Tyr Pro His Leu Ile Thr Lys Glu 
    930                 935                 940                 


Pro Phe Glu His Glu Ser Leu Leu Leu Asn Arg Lys Asp His Lys Leu 
945                 950                 955                 960 


Thr Lys Ala Glu Lys Lys Ala Ala Lys Lys Ser Tyr Glu Glu Asp Lys 
                965                 970                 975     


Arg Thr Ser Val Pro Tyr Thr Arg Pro Ser Tyr Ala Gln Tyr Tyr Pro 
            980                 985                 990         


Ala Ser Asp Gln Ser Leu Thr Ser  Ile Pro Ala Phe Ser  Gln Arg Asn 
        995                 1000                 1005             


Trp Gln  Pro Thr Leu Lys Gly  Asp Glu Lys Pro Val  Ala Ser Val 
    1010                 1015                 1020             


Arg Pro  Val Gln Ser Thr Pro  Ile Pro Met Met Pro  Arg His Val 
    1025                 1030                 1035             


Pro Leu  Gly Gly Ser Val Ser  Ser Ala Ser Ser Thr  Asn Pro Ser 
    1040                 1045                 1050             


Met Asn  Phe Pro Ile Asn Tyr  Leu Gln Arg Ala Gly  Val Leu Val 
    1055                 1060                 1065             


Gln Lys  Val Val Thr Thr Thr  Asp Ile Val Ile Pro  Gly Leu Asn 
    1070                 1075                 1080             


Ser Ser  Thr Asp Val Gln Ala  Arg Ile Asn Ala Gly  Glu Ser Ile 
    1085                 1090                 1095             


His Ile  Ile Arg Gly Thr Lys  Gly Thr Tyr Ile Arg  Thr Ser Asp 
    1100                 1105                 1110             


Gly Arg  Ile Phe Ala Val Arg  Ala Thr Gly Lys Pro  Lys Val Pro 
    1115                 1120                 1125             


Glu Asp  Gly Arg Met Ala Ala  Ser Gly Ser Gln Gly  Pro Ser Cys 
    1130                 1135                 1140             


Glu Ser  Thr Ser Asn Gly Arg  His Ser Ala Ser Ser  Pro Lys Ala 
    1145                 1150                 1155             


Pro Asp  Pro Glu Gly Leu Ala  Arg Pro Val Ser Pro  Asp Ser Pro 
    1160                 1165                 1170             


Glu Ile  Ile Ser Glu Leu Gln  Gln Tyr Ala Asp Val  Ala Ala Ala 
    1175                 1180                 1185             


Arg Glu  Ser Arg Gln Ser Ser  Pro Ser Thr Asn Ala  Ala Leu Pro 
    1190                 1195                 1200             


Gly Pro  Pro Ala Gln Leu Met  Asp Ser Ser Ala Val  Pro Gly Thr 
    1205                 1210                 1215             


Ala Leu  Gly Thr Glu Pro Arg  Leu Gly Gly His Cys  Leu Asn Ser 
    1220                 1225                 1230             


Ser Leu  Leu Val Thr Gly Gln  Pro Cys Gly Asp Arg  His Pro Val 
    1235                 1240                 1245             


Leu Asp  Leu Arg Gly His Lys  Arg Lys Leu Ala Thr  Pro Pro Ala 
    1250                 1255                 1260             


Ala Gln  Glu Ser Ser Arg Arg  Arg Ser Arg Lys Gly  His Leu Pro 
    1265                 1270                 1275             


Ala Pro  Val Gln Pro Tyr Glu  His Gly Tyr Pro Val  Ser Gly Gly 
    1280                 1285                 1290             


Phe Ala  Met Pro Pro Val Ser  Leu Asn His Asn Leu  Thr Thr Pro 
    1295                 1300                 1305             


Phe Thr  Ser Gln Ala Gly Glu  Asn Ser Leu Phe Met  Gly Ser Thr 
    1310                 1315                 1320             


Pro Ser  Tyr Tyr Gln Leu Ser  Asn Leu Leu Ala Asp  Ala Arg Leu 
    1325                 1330                 1335             


Val Phe  Pro Val Thr Thr Asp  Pro Leu Val Pro Ala  Gly Pro Val 
    1340                 1345                 1350             


Ser Ser  Ser Ser Thr Ala Thr  Ser Val Thr Ala Ser  Asn Pro Ser 
    1355                 1360                 1365             


Phe Met  Leu Asn Pro Ser Val  Pro Gly Ile Leu Pro  Ser Tyr Ser 
    1370                 1375                 1380             


Leu Pro  Phe Ser Gln Pro Leu  Leu Ser Glu Pro Arg  Met Phe Ala 
    1385                 1390                 1395             


Pro Phe  Pro Ser Pro Val Leu  Pro Ser Asn Leu Ser  Arg Gly Met 
    1400                 1405                 1410             


Ser Ile  Tyr Pro Gly Tyr Met  Ser Pro His Ala Gly  Tyr Pro Ala 
    1415                 1420                 1425             


Gly Gly  Leu Leu Arg Ser Gln  Val Pro Pro Phe Asp  Ser His Glu 
    1430                 1435                 1440             


Val Ala  Glu Val Gly Phe Ser  Ser Asn Asp Asp Glu  Asp Lys Asp 
    1445                 1450                 1455             


Asp Asp  Val Ile Glu Val Thr  Gly Lys 
    1460                 1465         


<210>  13
<211>  1158
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr His Gly Glu Glu Leu Gly Ser Asp Val His Gln Asp Ser Ile 
1               5                   10                  15      


Val Leu Thr Tyr Leu Glu Gly Leu Leu Met His Gln Ala Ala Gly Gly 
            20                  25                  30          


Ser Gly Thr Ala Val Asp Lys Lys Ser Ala Gly His Asn Glu Glu Asp 
        35                  40                  45              


Gln Asn Phe Asn Ile Ser Gly Ser Ala Phe Pro Thr Cys Gln Ser Asn 
    50                  55                  60                  


Gly Pro Val Leu Asn Thr His Thr Tyr Gln Gly Ser Gly Met Leu His 
65                  70                  75                  80  


Leu Lys Lys Ala Arg Leu Leu Gln Ser Ser Glu Asp Trp Asn Ala Ala 
                85                  90                  95      


Lys Arg Lys Arg Leu Ser Asp Ser Ile Met Asn Leu Asn Val Lys Lys 
            100                 105                 110         


Glu Ala Leu Leu Ala Gly Met Val Asp Ser Val Pro Lys Gly Lys Gln 
        115                 120                 125             


Asp Ser Thr Leu Leu Ala Ser Leu Leu Gln Ser Phe Ser Ser Arg Leu 
    130                 135                 140                 


Gln Thr Val Ala Leu Ser Gln Gln Ile Arg Gln Ser Leu Lys Glu Gln 
145                 150                 155                 160 


Gly Tyr Ala Leu Ser His Asp Ser Leu Lys Val Glu Lys Asp Leu Arg 
                165                 170                 175     


Cys Tyr Gly Val Ala Ser Ser His Leu Lys Thr Leu Leu Lys Lys Ser 
            180                 185                 190         


Lys Val Lys Asp Gln Lys Pro Asp Thr Asn Leu Pro Asp Val Thr Lys 
        195                 200                 205             


Asn Leu Ile Arg Asp Arg Phe Ala Glu Ser Pro His His Val Gly Gln 
    210                 215                 220                 


Ser Gly Thr Lys Val Met Ser Glu Pro Leu Ser Cys Ala Ala Arg Leu 
225                 230                 235                 240 


Gln Ala Val Ala Ser Met Val Glu Lys Arg Ala Ser Pro Ala Thr Ser 
                245                 250                 255     


Pro Lys Pro Ser Val Ala Cys Ser Gln Leu Ala Leu Leu Leu Ser Ser 
            260                 265                 270         


Glu Ala His Leu Gln Gln Tyr Ser Arg Glu His Ala Leu Lys Thr Gln 
        275                 280                 285             


Asn Ala Asn Gln Ala Ala Ser Glu Arg Leu Ala Ala Met Ala Arg Leu 
    290                 295                 300                 


Gln Glu Asn Gly Gln Lys Asp Val Gly Ser Tyr Gln Leu Pro Lys Gly 
305                 310                 315                 320 


Met Ser Ser His Leu Asn Gly Gln Ala Arg Thr Ser Ser Ser Lys Leu 
                325                 330                 335     


Met Ala Ser Lys Ser Ser Ala Thr Val Phe Gln Asn Pro Met Gly Ile 
            340                 345                 350         


Ile Pro Ser Ser Pro Lys Asn Ala Gly Tyr Lys Asn Ser Leu Glu Arg 
        355                 360                 365             


Asn Asn Ile Lys Gln Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu 
    370                 375                 380                 


Lys Ser Gln Thr Ile Pro Lys Pro Met Asn Gly His Ser His Ser Glu 
385                 390                 395                 400 


Arg Gly Ser Ile Phe Glu Glu Ser Ser Thr Pro Thr Thr Ile Asp Glu 
                405                 410                 415     


Tyr Ser Asp Asn Asn Pro Ser Phe Thr Asp Asp Ser Ser Gly Asp Glu 
            420                 425                 430         


Ser Ser Tyr Ser Asn Cys Val Pro Ile Asp Leu Ser Cys Lys His Arg 
        435                 440                 445             


Thr Glu Lys Ser Glu Ser Asp Gln Pro Val Ser Leu Asp Asn Phe Thr 
    450                 455                 460                 


Gln Ser Leu Leu Asn Thr Trp Asp Pro Lys Val Pro Asp Val Asp Ile 
465                 470                 475                 480 


Lys Glu Asp Gln Asp Thr Ser Lys Asn Ser Lys Leu Asn Ser His Gln 
                485                 490                 495     


Lys Val Thr Leu Leu Gln Leu Leu Leu Gly His Lys Asn Glu Glu Asn 
            500                 505                 510         


Val Glu Lys Asn Thr Ser Pro Gln Gly Val His Asn Asp Val Ser Lys 
        515                 520                 525             


Phe Asn Thr Gln Asn Tyr Ala Arg Thr Ser Val Ile Glu Ser Pro Ser 
    530                 535                 540                 


Thr Asn Arg Thr Thr Pro Val Ser Thr Pro Pro Leu Leu Thr Ser Ser 
545                 550                 555                 560 


Lys Ala Gly Ser Pro Ile Asn Leu Ser Gln His Ser Leu Val Ile Lys 
                565                 570                 575     


Trp Asn Ser Pro Pro Tyr Val Cys Ser Thr Gln Ser Glu Lys Leu Thr 
            580                 585                 590         


Asn Thr Ala Ser Asn His Ser Met Asp Leu Thr Lys Ser Lys Asp Pro 
        595                 600                 605             


Pro Gly Glu Lys Pro Ala Gln Asn Glu Gly Ala Gln Asn Ser Ala Thr 
    610                 615                 620                 


Phe Ser Ala Ser Lys Leu Leu Gln Asn Leu Ala Gln Cys Gly Met Gln 
625                 630                 635                 640 


Ser Ser Met Ser Val Glu Glu Gln Arg Pro Ser Lys Gln Leu Leu Thr 
                645                 650                 655     


Gly Asn Thr Asp Lys Pro Ile Gly Met Ile Asp Arg Leu Asn Ser Pro 
            660                 665                 670         


Leu Leu Ser Asn Lys Thr Asn Ala Val Glu Glu Asn Lys Ala Phe Ser 
        675                 680                 685             


Ser Gln Pro Thr Gly Pro Glu Pro Gly Leu Ser Gly Ser Glu Ile Glu 
    690                 695                 700                 


Asn Leu Leu Glu Arg Arg Thr Val Leu Gln Leu Leu Leu Gly Asn Pro 
705                 710                 715                 720 


Asn Lys Gly Lys Ser Glu Lys Lys Glu Lys Thr Pro Leu Arg Asp Glu 
                725                 730                 735     


Ser Thr Gln Glu His Ser Glu Arg Ala Leu Ser Glu Gln Ile Leu Met 
            740                 745                 750         


Val Lys Ile Lys Ser Glu Pro Cys Asp Asp Leu Gln Ile Pro Asn Thr 
        755                 760                 765             


Asn Val His Leu Ser His Asp Ala Lys Ser Ala Pro Phe Leu Gly Met 
    770                 775                 780                 


Ala Pro Ala Val Gln Arg Ser Ala Pro Ala Leu Pro Val Ser Glu Asp 
785                 790                 795                 800 


Phe Lys Ser Glu Pro Val Ser Pro Gln Asp Phe Ser Phe Ser Lys Asn 
                805                 810                 815     


Gly Leu Leu Ser Arg Leu Leu Arg Gln Asn Gln Asp Ser Tyr Leu Ala 
            820                 825                 830         


Asp Asp Ser Asp Arg Ser His Arg Asn Asn Glu Met Ala Leu Leu Glu 
        835                 840                 845             


Ser Lys Asn Leu Cys Met Val Pro Lys Lys Arg Lys Leu Tyr Thr Glu 
    850                 855                 860                 


Pro Leu Glu Asn Pro Phe Lys Lys Met Lys Asn Asn Ile Val Asp Ala 
865                 870                 875                 880 


Ala Asn Asn His Ser Ala Pro Glu Val Leu Tyr Gly Ser Leu Leu Asn 
                885                 890                 895     


Gln Glu Glu Leu Lys Phe Ser Arg Asn Asp Leu Glu Phe Lys Tyr Pro 
            900                 905                 910         


Ala Gly His Gly Ser Ala Ser Glu Ser Glu His Arg Ser Trp Ala Arg 
        915                 920                 925             


Glu Ser Lys Ser Phe Asn Val Leu Lys Gln Leu Leu Leu Ser Glu Asn 
    930                 935                 940                 


Cys Val Arg Asp Leu Ser Pro His Arg Ser Asn Ser Val Ala Asp Ser 
945                 950                 955                 960 


Lys Lys Lys Gly His Lys Asn Asn Val Thr Asn Ser Lys Pro Glu Phe 
                965                 970                 975     


Ser Ile Ser Ser Leu Asn Gly Leu Met Tyr Ser Ser Thr Gln Pro Ser 
            980                 985                 990         


Ser Cys Met Asp Asn Arg Thr Phe  Ser Tyr Pro Gly Val  Val Lys Thr 
        995                 1000                 1005             


Pro Val  Ser Pro Thr Phe Pro  Glu His Leu Gly Cys  Ala Gly Ser 
    1010                 1015                 1020             


Arg Pro  Glu Ser Gly Leu Leu  Asn Gly Cys Ser Met  Pro Ser Glu 
    1025                 1030                 1035             


Lys Gly  Pro Ile Lys Trp Val  Ile Thr Asp Ala Glu  Lys Asn Glu 
    1040                 1045                 1050             


Tyr Glu  Lys Asp Ser Pro Arg  Leu Thr Lys Thr Asn  Pro Ile Leu 
    1055                 1060                 1065             


Tyr Tyr  Met Leu Gln Lys Gly  Gly Asn Ser Val Thr  Ser Arg Glu 
    1070                 1075                 1080             


Thr Gln  Asp Lys Asp Ile Trp  Arg Glu Ala Ser Ser  Ala Glu Ser 
    1085                 1090                 1095             


Val Ser  Gln Val Thr Ala Lys  Glu Glu Leu Leu Pro  Thr Ala Glu 
    1100                 1105                 1110             


Thr Lys  Ala Ser Phe Phe Asn  Leu Arg Ser Pro Tyr  Asn Ser His 
    1115                 1120                 1125             


Met Gly  Asn Asn Ala Ser Arg  Pro His Ser Ala Asn  Gly Glu Val 
    1130                 1135                 1140             


Tyr Gly  Leu Leu Gly Ser Val  Leu Thr Ile Lys Lys  Glu Ser Glu 
    1145                 1150                 1155             


<210>  14
<211>  1494
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asn Gly Gly Lys Glu Cys Asp Gly Gly Asp Lys Glu Gly Gly Leu 
1               5                   10                  15      


Pro Ala Ile Gln Val Pro Val Gly Trp Gln Arg Arg Val Asp Gln Asn 
            20                  25                  30          


Gly Val Leu Tyr Val Ser Pro Ser Gly Ser Leu Leu Ser Cys Leu Glu 
        35                  40                  45              


Gln Val Lys Thr Tyr Leu Leu Thr Asp Gly Thr Cys Lys Cys Gly Leu 
    50                  55                  60                  


Glu Cys Pro Leu Ile Leu Pro Lys Val Phe Asn Phe Asp Pro Gly Ala 
65                  70                  75                  80  


Ala Val Lys Gln Arg Thr Ala Glu Asp Val Lys Ala Asp Glu Asp Val 
                85                  90                  95      


Thr Lys Leu Cys Ile His Lys Arg Lys Ile Ile Ala Val Ala Thr Leu 
            100                 105                 110         


His Lys Ser Met Glu Ala Pro His Pro Ser Leu Val Leu Thr Ser Pro 
        115                 120                 125             


Gly Gly Gly Thr Asn Ala Thr Pro Val Val Pro Ser Arg Ala Ala Thr 
    130                 135                 140                 


Pro Arg Ser Val Arg Asn Lys Ser His Glu Gly Ile Thr Asn Ser Val 
145                 150                 155                 160 


Met Pro Glu Cys Lys Asn Pro Phe Lys Leu Met Ile Gly Ser Ser Asn 
                165                 170                 175     


Ala Met Gly Arg Leu Tyr Val Gln Glu Leu Pro Gly Ser Gln Gln Gln 
            180                 185                 190         


Glu Leu His Pro Val Tyr Pro Arg Gln Arg Leu Gly Ser Ser Glu His 
        195                 200                 205             


Gly Gln Lys Ser Pro Phe Arg Gly Ser His Gly Gly Leu Pro Ser Pro 
    210                 215                 220                 


Ala Ser Ser Gly Ser Gln Ile Tyr Gly Asp Gly Ser Ile Ser Pro Arg 
225                 230                 235                 240 


Thr Asp Pro Leu Gly Ser Pro Asp Val Phe Thr Arg Ser Asn Pro Gly 
                245                 250                 255     


Phe His Gly Ala Pro Asn Ser Ser Pro Ile His Leu Asn Arg Thr Pro 
            260                 265                 270         


Leu Ser Pro Pro Ser Val Met Leu His Gly Ser Pro Val Gln Ser Ser 
        275                 280                 285             


Cys Ala Met Ala Gly Arg Thr Asn Ile Pro Leu Ser Pro Thr Leu Thr 
    290                 295                 300                 


Thr Lys Ser Pro Val Met Lys Lys Pro Met Cys Asn Phe Ser Thr Asn 
305                 310                 315                 320 


Met Glu Ile Pro Arg Ala Met Phe His His Lys Pro Pro Gln Gly Pro 
                325                 330                 335     


Pro Pro Pro Pro Pro Pro Ser Cys Ala Leu Gln Lys Lys Pro Leu Thr 
            340                 345                 350         


Ser Glu Lys Asp Pro Leu Gly Ile Leu Asp Pro Ile Pro Ser Lys Pro 
        355                 360                 365             


Val Asn Gln Asn Pro Val Ile Ile Asn Pro Thr Ser Phe His Ser Asn 
    370                 375                 380                 


Val His Ser Gln Val Pro Met Met Asn Val Ser Met Pro Pro Ala Val 
385                 390                 395                 400 


Val Pro Leu Pro Ser Asn Leu Pro Leu Pro Thr Val Lys Pro Gly His 
                405                 410                 415     


Met Asn His Gly Ser His Val Gln Arg Val Gln His Ser Ala Ser Thr 
            420                 425                 430         


Ser Leu Ser Pro Ser Pro Val Thr Ser Pro Val His Met Met Gly Thr 
        435                 440                 445             


Gly Ile Gly Arg Ile Glu Ala Ser Pro Gln Arg Ser Arg Ser Ser Ser 
    450                 455                 460                 


Thr Ser Ser Asp His Gly Asn Phe Met Met Pro Pro Val Gly Pro Gln 
465                 470                 475                 480 


Ala Thr Ser Ser Gly Ile Lys Val Pro Pro Arg Ser Pro Arg Ser Thr 
                485                 490                 495     


Ile Gly Ser Pro Arg Pro Ser Met Pro Ser Ser Pro Ser Thr Lys Ser 
            500                 505                 510         


Asp Gly His His Gln Tyr Lys Asp Ile Pro Asn Pro Leu Ile Ala Gly 
        515                 520                 525             


Ile Ser Asn Val Leu Asn Thr Pro Ser Ser Ala Ala Phe Pro Thr Ala 
    530                 535                 540                 


Ser Ala Gly Ser Ser Ser Val Lys Ser Gln Pro Gly Leu Leu Gly Met 
545                 550                 555                 560 


Pro Leu Asn Gln Ile Leu Asn Gln His Asn Ala Ala Ser Phe Pro Ala 
                565                 570                 575     


Ser Ser Leu Leu Ser Ala Ala Ala Lys Ala Gln Leu Ala Asn Gln Asn 
            580                 585                 590         


Lys Leu Ala Gly Asn Asn Ser Ser Ser Ser Ser Asn Ser Gly Ala Val 
        595                 600                 605             


Ala Gly Ser Gly Asn Thr Glu Gly His Ser Thr Leu Asn Thr Met Phe 
    610                 615                 620                 


Pro Pro Thr Ala Asn Met Leu Leu Pro Thr Gly Glu Gly Gln Ser Gly 
625                 630                 635                 640 


Arg Ala Ala Leu Arg Asp Lys Leu Met Ser Gln Gln Lys Asp Ala Leu 
                645                 650                 655     


Arg Lys Arg Lys Gln Pro Pro Thr Thr Val Leu Ser Leu Leu Arg Gln 
            660                 665                 670         


Ser Gln Met Asp Ser Ser Ala Val Pro Lys Pro Gly Pro Asp Leu Leu 
        675                 680                 685             


Arg Lys Gln Gly Gln Gly Ser Phe Pro Ile Ser Ser Met Ser Gln Leu 
    690                 695                 700                 


Leu Gln Ser Met Ser Cys Gln Ser Ser His Leu Ser Ser Asn Ser Thr 
705                 710                 715                 720 


Pro Gly Cys Gly Ala Ser Asn Thr Ala Leu Pro Cys Ser Ala Asn Gln 
                725                 730                 735     


Leu His Phe Thr Asp Pro Ser Met Asn Ser Ser Val Leu Gln Asn Ile 
            740                 745                 750         


Pro Leu Arg Gly Glu Ala Val His Cys His Asn Ala Asn Thr Asn Phe 
        755                 760                 765             


Val His Ser Asn Ser Pro Val Pro Asn His His Leu Ala Gly Leu Ile 
    770                 775                 780                 


Asn Gln Ile Gln Ala Ser Gly Asn Cys Gly Met Leu Ser Gln Ser Gly 
785                 790                 795                 800 


Met Ala Leu Gly Asn Ser Leu His Pro Asn Pro Pro Gln Ser Arg Ile 
                805                 810                 815     


Ser Thr Ser Ser Thr Pro Val Ile Pro Asn Ser Ile Val Ser Ser Tyr 
            820                 825                 830         


Asn Gln Thr Ser Ser Glu Ala Gly Gly Ser Gly Pro Ser Ser Ser Ile 
        835                 840                 845             


Ala Ile Ala Gly Thr Asn His Pro Ala Ile Thr Lys Thr Thr Ser Val 
    850                 855                 860                 


Leu Gln Asp Gly Val Ile Val Thr Thr Ala Ala Gly Asn Pro Leu Gln 
865                 870                 875                 880 


Ser Gln Leu Pro Ile Gly Ser Asp Phe Pro Phe Val Gly Gln Glu His 
                885                 890                 895     


Ala Leu His Phe Pro Ser Asn Ser Thr Ser Asn Asn His Leu Pro His 
            900                 905                 910         


Pro Leu Asn Pro Ser Leu Leu Ser Ser Leu Pro Ile Ser Leu Pro Val 
        915                 920                 925             


Asn Gln Gln His Leu Leu Asn Gln Asn Leu Leu Asn Ile Leu Gln Pro 
    930                 935                 940                 


Ser Ala Gly Glu Gly Asp Met Ser Ser Ile Asn Asn Thr Leu Ser Asn 
945                 950                 955                 960 


His Gln Leu Thr His Leu Gln Ser Leu Leu Asn Asn Asn Gln Met Phe 
                965                 970                 975     


Pro Pro Asn Gln Gln Gln Gln Gln Leu Leu Gln Gly Tyr Gln Asn Leu 
            980                 985                 990         


Gln Ala Phe Gln Gly Gln Ser Thr  Ile Pro Cys Pro Ala  Asn Asn Asn 
        995                 1000                 1005             


Pro Met  Ala Cys Leu Phe Gln  Asn Phe Gln Val Arg  Met Gln Glu 
    1010                 1015                 1020             


Asp Ala  Ala Leu Leu Asn Lys  Arg Ile Ser Thr Gln  Pro Gly Leu 
    1025                 1030                 1035             


Thr Ala  Leu Pro Glu Asn Pro  Asn Thr Thr Leu Pro  Pro Phe Gln 
    1040                 1045                 1050             


Asp Thr  Pro Cys Glu Leu Gln  Pro Arg Ile Asp Pro  Ser Leu Gly 
    1055                 1060                 1065             


Gln Gln  Val Lys Asp Gly Leu  Val Val Gly Gly Pro  Gly Asp Ala 
    1070                 1075                 1080             


Ser Val  Asp Ala Ile Tyr Lys  Ala Val Val Asp Ala  Ala Ser Lys 
    1085                 1090                 1095             


Gly Met  Gln Val Val Ile Thr  Thr Ala Val Asn Ser  Thr Thr Gln 
    1100                 1105                 1110             


Ile Ser  Pro Ile Pro Ala Leu  Ser Ala Met Ser Ala  Phe Thr Ala 
    1115                 1120                 1125             


Ser Ile  Gly Asp Pro Leu Asn  Leu Ser Ser Ala Val  Ser Ala Val 
    1130                 1135                 1140             


Ile His  Gly Arg Asn Met Gly  Gly Val Asp His Asp  Gly Arg Leu 
    1145                 1150                 1155             


Arg Asn  Ser Arg Gly Ala Arg  Leu Pro Lys Asn Leu  Asp His Gly 
    1160                 1165                 1170             


Lys Asn  Val Asn Glu Gly Asp  Gly Phe Glu Tyr Phe  Lys Ser Ala 
    1175                 1180                 1185             


Ser Cys  His Thr Ser Lys Lys  Gln Trp Asp Gly Glu  Gln Ser Pro 
    1190                 1195                 1200             


Arg Gly  Glu Arg Asn Arg Trp  Lys Tyr Glu Glu Phe  Leu Asp His 
    1205                 1210                 1215             


Pro Gly  His Ile His Ser Ser  Pro Cys His Glu Arg  Pro Asn Asn 
    1220                 1225                 1230             


Val Ser  Thr Leu Pro Phe Leu  Pro Gly Glu Gln His  Pro Ile Leu 
    1235                 1240                 1245             


Leu Pro  Pro Arg Asn Cys Pro  Gly Asp Lys Ile Leu  Glu Glu Asn 
    1250                 1255                 1260             


Phe Arg  Tyr Asn Asn Tyr Lys  Arg Thr Met Met Ser  Phe Lys Glu 
    1265                 1270                 1275             


Arg Leu  Glu Asn Thr Val Glu  Arg Cys Ala His Ile  Asn Gly Asn 
    1280                 1285                 1290             


Arg Pro  Arg Gln Ser Arg Gly  Phe Gly Glu Leu Leu  Ser Thr Ala 
    1295                 1300                 1305             


Lys Gln  Asp Leu Val Leu Glu  Glu Gln Ser Pro Ser  Ser Ser Asn 
    1310                 1315                 1320             


Ser Leu  Glu Asn Ser Leu Val  Lys Asp Tyr Ile His  Tyr Asn Gly 
    1325                 1330                 1335             


Asp Phe  Asn Ala Lys Ser Val  Asn Gly Cys Val Pro  Ser Pro Ser 
    1340                 1345                 1350             


Asp Ala  Lys Ser Ile Ser Ser  Glu Asp Asp Leu Arg  Asn Pro Asp 
    1355                 1360                 1365             


Ser Pro  Ser Ser Asn Glu Leu  Ile His Tyr Arg Pro  Arg Thr Phe 
    1370                 1375                 1380             


Asn Val  Gly Asp Leu Val Trp  Gly Gln Ile Lys Gly  Leu Thr Ser 
    1385                 1390                 1395             


Trp Pro  Gly Lys Leu Val Arg  Glu Asp Asp Val His  Asn Ser Cys 
    1400                 1405                 1410             


Gln Gln  Ser Pro Glu Glu Gly  Lys Val Glu Pro Glu  Lys Leu Lys 
    1415                 1420                 1425             


Thr Leu  Thr Glu Gly Leu Glu  Ala Tyr Ser Arg Val  Arg Lys Arg 
    1430                 1435                 1440             


Asn Arg  Lys Ser Gly Lys Leu  Asn Asn His Leu Glu  Ala Ala Ile 
    1445                 1450                 1455             


His Glu  Ala Met Ser Glu Leu  Asp Lys Met Ser Gly  Thr Val His 
    1460                 1465                 1470             


Gln Ile  Pro Gln Gly Asp Arg  Gln Met Arg Pro Pro  Lys Pro Lys 
    1475                 1480                 1485             


Arg Arg  Lys Ile Ser Arg 
    1490                 


<210>  15
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Ser Ser His Leu Leu Asn Lys Gly Leu Pro Leu Gly Val Arg 
1               5                   10                  15      


Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg Pro Leu Val Ala Leu 
            20                  25                  30          


Leu Asp Gly Arg Asp Cys Thr Val Glu Met Pro Ile Leu Lys Asp Val 
        35                  40                  45              


Ala Thr Val Ala Phe Cys Asp Ala Gln Ser Thr Gln Glu Ile His Glu 
    50                  55                  60                  


Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met Tyr His Thr Ile Thr 
65                  70                  75                  80  


Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys Ala Leu Arg Ile Ile Val 
                85                  90                  95      


Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile Lys Ser Ala Gly Asp 
            100                 105                 110         


Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala Ser Val Glu Glu Thr 
        115                 120                 125             


Ala Asp Ser Thr Leu Cys His Ile Leu Asn Leu Tyr Arg Arg Ala Thr 
    130                 135                 140                 


Trp Leu His Gln Ala Leu Arg Glu Gly Thr Arg Val Gln Ser Val Glu 
145                 150                 155                 160 


Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly Glu Thr 
                165                 170                 175     


Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln Ala Val Ala Leu Arg 
            180                 185                 190         


Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr Asp Pro Tyr Leu Ser 
        195                 200                 205             


Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg Val Ser Thr Leu Gln 
    210                 215                 220                 


Asp Leu Leu Phe His Ser Asp Cys Val Thr Leu His Cys Gly Leu Asn 
225                 230                 235                 240 


Glu His Asn His His Leu Ile Asn Asp Phe Thr Val Lys Gln Met Arg 
                245                 250                 255     


Gln Gly Ala Phe Leu Val Asn Thr Ala Arg Gly Gly Leu Val Asp Glu 
            260                 265                 270         


Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly Ala Ala 
        275                 280                 285             


Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe Ser Gln Gly Pro Leu 
    290                 295                 300                 


Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro His Ala Ala Trp Tyr Ser 
305                 310                 315                 320 


Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala Ala Arg Glu Ile Arg 
                325                 330                 335     


Arg Ala Ile Thr Gly Arg Ile Pro Asp Ser Leu Lys Asn Cys Val Asn 
            340                 345                 350         


Lys Asp His Leu Thr Ala Ala Thr His Trp Ala Ser Met Asp Pro Ala 
        355                 360                 365             


Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr Arg Tyr Pro Pro Gly 
    370                 375                 380                 


Val Val Gly Val Ala Pro Thr Gly Ile Pro Ala Ala Val Glu Gly Ile 
385                 390                 395                 400 


Val Pro Ser Ala Met Ser Leu Ser His Gly Leu Pro Pro Val Ala His 
                405                 410                 415     


Pro Pro His Ala Pro Ser Pro Gly Gln Thr Val Lys Pro Glu Ala Asp 
            420                 425                 430         


Arg Asp His Ala Ser Asp Gln Leu 
        435                 440 


<210>  16
<211>  1791
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Asp Arg Cys Tyr Pro Val Ile Phe Pro Asp Glu Arg Asn Phe 
1               5                   10                  15      


Arg Pro Phe Thr Ser Asp Ser Leu Ala Ala Ile Glu Lys Arg Ile Ala 
            20                  25                  30          


Ile Gln Lys Glu Lys Lys Lys Ser Lys Asp Gln Thr Gly Glu Val Pro 
        35                  40                  45              


Gln Pro Arg Pro Gln Leu Asp Leu Lys Ala Ser Arg Lys Leu Pro Lys 
    50                  55                  60                  


Leu Tyr Gly Asp Ile Pro Arg Glu Leu Ile Gly Lys Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Phe Tyr Arg Asn His Lys Thr Phe Met Val Leu Asn Arg 
                85                  90                  95      


Lys Arg Thr Ile Tyr Arg Phe Ser Ala Lys His Ala Leu Phe Ile Phe 
            100                 105                 110         


Gly Pro Phe Asn Ser Ile Arg Ser Leu Ala Ile Arg Val Ser Val His 
        115                 120                 125             


Ser Leu Phe Ser Met Phe Ile Ile Gly Thr Val Ile Ile Asn Cys Val 
    130                 135                 140                 


Phe Met Ala Thr Gly Pro Ala Lys Asn Ser Asn Ser Asn Asn Thr Asp 
145                 150                 155                 160 


Ile Ala Glu Cys Val Phe Thr Gly Ile Tyr Ile Phe Glu Ala Leu Ile 
                165                 170                 175     


Lys Ile Leu Ala Arg Gly Phe Ile Leu Asp Glu Phe Ser Phe Leu Arg 
            180                 185                 190         


Asp Pro Trp Asn Trp Leu Asp Ser Ile Val Ile Gly Ile Ala Ile Val 
        195                 200                 205             


Ser Tyr Ile Pro Gly Ile Thr Ile Lys Leu Leu Pro Leu Arg Thr Phe 
    210                 215                 220                 


Arg Val Phe Arg Ala Leu Lys Ala Ile Ser Val Val Ser Arg Leu Lys 
225                 230                 235                 240 


Val Ile Val Gly Ala Leu Leu Arg Ser Val Lys Lys Leu Val Asn Val 
                245                 250                 255     


Ile Ile Leu Thr Phe Phe Cys Leu Ser Ile Phe Ala Leu Val Gly Gln 
            260                 265                 270         


Gln Leu Phe Met Gly Ser Leu Asn Leu Lys Cys Ile Ser Arg Asp Cys 
        275                 280                 285             


Lys Asn Ile Ser Asn Pro Glu Ala Tyr Asp His Cys Phe Glu Lys Lys 
    290                 295                 300                 


Glu Asn Ser Pro Glu Phe Lys Met Cys Gly Ile Trp Met Gly Asn Ser 
305                 310                 315                 320 


Ala Cys Ser Ile Gln Tyr Glu Cys Lys His Thr Lys Ile Asn Pro Asp 
                325                 330                 335     


Tyr Asn Tyr Thr Asn Phe Asp Asn Phe Gly Trp Ser Phe Leu Ala Met 
            340                 345                 350         


Phe Arg Leu Met Thr Gln Asp Ser Trp Glu Lys Leu Tyr Gln Gln Thr 
        355                 360                 365             


Leu Arg Thr Thr Gly Leu Tyr Ser Val Phe Phe Phe Ile Val Val Ile 
    370                 375                 380                 


Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Thr Leu Ala Val Val Thr 
385                 390                 395                 400 


Met Ala Tyr Glu Glu Gln Asn Lys Asn Val Ala Ala Glu Ile Glu Ala 
                405                 410                 415     


Lys Glu Lys Met Phe Gln Glu Ala Gln Gln Leu Leu Lys Glu Glu Lys 
            420                 425                 430         


Glu Ala Leu Val Ala Met Gly Ile Asp Arg Ser Ser Leu Thr Ser Leu 
        435                 440                 445             


Glu Thr Ser Tyr Phe Thr Pro Lys Lys Arg Lys Leu Phe Gly Asn Lys 
    450                 455                 460                 


Lys Arg Lys Ser Phe Phe Leu Arg Glu Ser Gly Lys Asp Gln Pro Pro 
465                 470                 475                 480 


Gly Ser Asp Ser Asp Glu Asp Cys Gln Lys Lys Pro Gln Leu Leu Glu 
                485                 490                 495     


Gln Thr Lys Arg Leu Ser Gln Asn Leu Ser Leu Asp His Phe Asp Glu 
            500                 505                 510         


His Gly Asp Pro Leu Gln Arg Gln Arg Ala Leu Ser Ala Val Ser Ile 
        515                 520                 525             


Leu Thr Ile Thr Met Lys Glu Gln Glu Lys Ser Gln Glu Pro Cys Leu 
    530                 535                 540                 


Pro Cys Gly Glu Asn Leu Ala Ser Lys Tyr Leu Val Trp Asn Cys Cys 
545                 550                 555                 560 


Pro Gln Trp Leu Cys Val Lys Lys Val Leu Arg Thr Val Met Thr Asp 
                565                 570                 575     


Pro Phe Thr Glu Leu Ala Ile Thr Ile Cys Ile Ile Ile Asn Thr Val 
            580                 585                 590         


Phe Leu Ala Met Glu His His Lys Met Glu Ala Ser Phe Glu Lys Met 
        595                 600                 605             


Leu Asn Ile Gly Asn Leu Val Phe Thr Ser Ile Phe Ile Ala Glu Met 
    610                 615                 620                 


Cys Leu Lys Ile Ile Ala Leu Asp Pro Tyr His Tyr Phe Arg Arg Gly 
625                 630                 635                 640 


Trp Asn Ile Phe Asp Ser Ile Val Ala Leu Leu Ser Phe Ala Asp Val 
                645                 650                 655     


Met Asn Cys Val Leu Gln Lys Arg Ser Trp Pro Phe Leu Arg Ser Phe 
            660                 665                 670         


Arg Val Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn 
        675                 680                 685             


Thr Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Ser Leu 
    690                 695                 700                 


Thr Val Val Leu Val Ile Val Ile Phe Ile Phe Ser Val Val Gly Met 
705                 710                 715                 720 


Gln Leu Phe Gly Arg Ser Phe Asn Ser Gln Lys Ser Pro Lys Leu Cys 
                725                 730                 735     


Asn Pro Thr Gly Pro Thr Val Ser Cys Leu Arg His Trp His Met Gly 
            740                 745                 750         


Asp Phe Trp His Ser Phe Leu Val Val Phe Arg Ile Leu Cys Gly Glu 
        755                 760                 765             


Trp Ile Glu Asn Met Trp Glu Cys Met Gln Glu Ala Asn Ala Ser Ser 
    770                 775                 780                 


Ser Leu Cys Val Ile Val Phe Ile Leu Ile Thr Val Ile Gly Lys Leu 
785                 790                 795                 800 


Val Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Asn 
                805                 810                 815     


Glu Glu Arg Asn Gly Asn Leu Glu Gly Glu Ala Arg Lys Thr Lys Val 
            820                 825                 830         


Gln Leu Ala Leu Asp Arg Phe Arg Arg Ala Phe Cys Phe Val Arg His 
        835                 840                 845             


Thr Leu Glu His Phe Cys His Lys Trp Cys Arg Lys Gln Asn Leu Pro 
    850                 855                 860                 


Gln Gln Lys Glu Val Ala Gly Gly Cys Ala Ala Gln Ser Lys Asp Ile 
865                 870                 875                 880 


Ile Pro Leu Val Met Glu Met Lys Arg Gly Ser Glu Thr Gln Glu Glu 
                885                 890                 895     


Leu Gly Ile Leu Thr Ser Val Pro Lys Thr Leu Gly Val Arg His Asp 
            900                 905                 910         


Trp Thr Trp Leu Ala Pro Leu Ala Glu Glu Glu Asp Asp Val Glu Phe 
        915                 920                 925             


Ser Gly Glu Asp Asn Ala Gln Arg Ile Thr Gln Pro Glu Pro Glu Gln 
    930                 935                 940                 


Gln Ala Tyr Glu Leu His Gln Glu Asn Lys Lys Pro Thr Ser Gln Arg 
945                 950                 955                 960 


Val Gln Ser Val Glu Ile Asp Met Phe Ser Glu Asp Glu Pro His Leu 
                965                 970                 975     


Thr Ile Gln Asp Pro Arg Lys Lys Ser Asp Val Thr Ser Ile Leu Ser 
            980                 985                 990         


Glu Cys Ser Thr Ile Asp Leu Gln  Asp Gly Phe Gly Trp  Leu Pro Glu 
        995                 1000                 1005             


Met Val  Pro Lys Lys Gln Pro  Glu Arg Cys Leu Pro  Lys Gly Phe 
    1010                 1015                 1020             


Gly Cys  Cys Phe Pro Cys Cys  Ser Val Asp Lys Arg  Lys Pro Pro 
    1025                 1030                 1035             


Trp Val  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Gln Ile Val 
    1040                 1045                 1050             


Lys His  Ser Trp Phe Glu Ser  Phe Ile Ile Phe Val  Ile Leu Leu 
    1055                 1060                 1065             


Ser Ser  Gly Ala Leu Ile Phe  Glu Asp Val His Leu  Glu Asn Gln 
    1070                 1075                 1080             


Pro Lys  Ile Gln Glu Leu Leu  Asn Cys Thr Asp Ile  Ile Phe Thr 
    1085                 1090                 1095             


His Ile  Phe Ile Leu Glu Met  Val Leu Lys Trp Val  Ala Phe Gly 
    1100                 1105                 1110             


Phe Gly  Lys Tyr Phe Thr Ser  Ala Trp Cys Cys Leu  Asp Phe Ile 
    1115                 1120                 1125             


Ile Val  Ile Val Ser Val Thr  Thr Leu Ile Asn Leu  Met Glu Leu 
    1130                 1135                 1140             


Lys Ser  Phe Arg Thr Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu 
    1145                 1150                 1155             


Ser Gln  Phe Glu Gly Met Lys  Val Val Val Asn Ala  Leu Ile Gly 
    1160                 1165                 1170             


Ala Ile  Pro Ala Ile Leu Asn  Val Leu Leu Val Cys  Leu Ile Phe 
    1175                 1180                 1185             


Trp Leu  Val Phe Cys Ile Leu  Gly Val Tyr Phe Phe  Ser Gly Lys 
    1190                 1195                 1200             


Phe Gly  Lys Cys Ile Asn Gly  Thr Asp Ser Val Ile  Asn Tyr Thr 
    1205                 1210                 1215             


Ile Ile  Thr Asn Lys Ser Gln  Cys Glu Ser Gly Asn  Phe Ser Trp 
    1220                 1225                 1230             


Ile Asn  Gln Lys Val Asn Phe  Asp Asn Val Gly Asn  Ala Tyr Leu 
    1235                 1240                 1245             


Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Ile 
    1250                 1255                 1260             


Tyr Ala  Ala Val Asp Ser Thr  Glu Lys Glu Gln Gln  Pro Glu Phe 
    1265                 1270                 1275             


Glu Ser  Asn Ser Leu Gly Tyr  Ile Tyr Phe Val Val  Phe Ile Ile 
    1280                 1285                 1290             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1295                 1300                 1305             


Asp Asn  Phe Asn Gln Gln Gln  Lys Lys Leu Gly Gly  Gln Asp Ile 
    1310                 1315                 1320             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1325                 1330                 1335             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Leu Asn 
    1340                 1345                 1350             


Lys Cys  Gln Gly Leu Val Phe  Asp Ile Val Thr Ser  Gln Ile Phe 
    1355                 1360                 1365             


Asp Ile  Ile Ile Ile Ser Leu  Ile Ile Leu Asn Met  Ile Ser Met 
    1370                 1375                 1380             


Met Ala  Glu Ser Tyr Asn Gln  Pro Lys Ala Met Lys  Ser Ile Leu 
    1385                 1390                 1395             


Asp His  Leu Asn Trp Val Phe  Val Val Ile Phe Thr  Leu Glu Cys 
    1400                 1405                 1410             


Leu Ile  Lys Ile Phe Ala Leu  Arg Gln Tyr Tyr Phe  Thr Asn Gly 
    1415                 1420                 1425             


Trp Asn  Leu Phe Asp Cys Val  Val Val Leu Leu Ser  Ile Val Ser 
    1430                 1435                 1440             


Thr Met  Ile Ser Thr Leu Glu  Asn Gln Glu His Ile  Pro Phe Pro 
    1445                 1450                 1455             


Pro Thr  Leu Phe Arg Ile Val  Arg Leu Ala Arg Ile  Gly Arg Ile 
    1460                 1465                 1470             


Leu Arg  Leu Val Arg Ala Ala  Arg Gly Ile Arg Thr  Leu Leu Phe 
    1475                 1480                 1485             


Ala Leu  Met Met Ser Leu Pro  Ser Leu Phe Asn Ile  Gly Leu Leu 
    1490                 1495                 1500             


Leu Phe  Leu Ile Met Phe Ile  Tyr Ala Ile Leu Gly  Met Asn Trp 
    1505                 1510                 1515             


Phe Ser  Lys Val Asn Pro Glu  Ser Gly Ile Asp Asp  Ile Phe Asn 
    1520                 1525                 1530             


Phe Lys  Thr Phe Ala Ser Ser  Met Leu Cys Leu Phe  Gln Ile Ser 
    1535                 1540                 1545             


Thr Ser  Ala Gly Trp Asp Ser  Leu Leu Ser Pro Met  Leu Arg Ser 
    1550                 1555                 1560             


Lys Glu  Ser Cys Asn Ser Ser  Ser Glu Asn Cys His  Leu Pro Gly 
    1565                 1570                 1575             


Ile Ala  Thr Ser Tyr Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu 
    1580                 1585                 1590             


Ile Val  Val Asn Met Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Asn 
    1595                 1600                 1605             


Thr Ala  Thr Glu Glu Ser Glu  Asp Pro Leu Gly Glu  Asp Asp Phe 
    1610                 1615                 1620             


Asp Ile  Phe Tyr Glu Val Trp  Glu Lys Phe Asp Pro  Glu Ala Thr 
    1625                 1630                 1635             


Gln Phe  Ile Lys Tyr Ser Ala  Leu Ser Asp Phe Ala  Asp Ala Leu 
    1640                 1645                 1650             


Pro Glu  Pro Leu Arg Val Ala  Lys Pro Asn Lys Tyr  Gln Phe Leu 
    1655                 1660                 1665             


Val Met  Asp Leu Pro Met Val  Ser Glu Asp Arg Leu  His Cys Met 
    1670                 1675                 1680             


Asp Ile  Leu Phe Ala Phe Thr  Ala Arg Val Leu Gly  Gly Ser Asp 
    1685                 1690                 1695             


Gly Leu  Asp Ser Met Lys Ala  Met Met Glu Glu Lys  Phe Met Glu 
    1700                 1705                 1710             


Ala Asn  Pro Leu Lys Lys Leu  Tyr Glu Pro Ile Val  Thr Thr Thr 
    1715                 1720                 1725             


Lys Arg  Lys Glu Glu Glu Arg  Gly Ala Ala Ile Ile  Gln Lys Ala 
    1730                 1735                 1740             


Phe Arg  Lys Tyr Met Met Lys  Val Thr Lys Gly Asp  Gln Gly Asp 
    1745                 1750                 1755             


Gln Asn  Asp Leu Glu Asn Gly  Pro His Ser Pro Leu  Gln Thr Leu 
    1760                 1765                 1770             


Cys Asn  Gly Asp Leu Ser Ser  Phe Gly Val Ala Lys  Gly Lys Val 
    1775                 1780                 1785             


His Cys  Asp 
    1790     


<210>  17
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Gly Trp Ser Cys Leu Val Thr Gly Ala Gly Gly Phe Leu Gly 
1               5                   10                  15      


Gln Arg Ile Ile Arg Leu Leu Val Lys Glu Lys Glu Leu Lys Glu Ile 
            20                  25                  30          


Arg Val Leu Asp Lys Ala Phe Gly Pro Glu Leu Arg Glu Glu Phe Ser 
        35                  40                  45              


Lys Leu Gln Asn Lys Thr Lys Leu Thr Val Leu Glu Gly Asp Ile Leu 
    50                  55                  60                  


Asp Glu Pro Phe Leu Lys Arg Ala Cys Gln Asp Val Ser Val Ile Ile 
65                  70                  75                  80  


His Thr Ala Cys Ile Ile Asp Val Phe Gly Val Thr His Arg Glu Ser 
                85                  90                  95      


Ile Met Asn Val Asn Val Lys Gly Thr Gln Leu Leu Leu Glu Ala Cys 
            100                 105                 110         


Val Gln Ala Ser Val Pro Val Phe Ile Tyr Thr Ser Ser Ile Glu Val 
        115                 120                 125             


Ala Gly Pro Asn Ser Tyr Lys Glu Ile Ile Gln Asn Gly His Glu Glu 
    130                 135                 140                 


Glu Pro Leu Glu Asn Thr Trp Pro Ala Pro Tyr Pro His Ser Lys Lys 
145                 150                 155                 160 


Leu Ala Glu Lys Ala Val Leu Ala Ala Asn Gly Trp Asn Leu Lys Asn 
                165                 170                 175     


Gly Gly Thr Leu Tyr Thr Cys Ala Leu Arg Pro Met Tyr Ile Tyr Gly 
            180                 185                 190         


Glu Gly Ser Arg Phe Leu Ser Ala Ser Ile Asn Glu Ala Leu Asn Asn 
        195                 200                 205             


Asn Gly Ile Leu Ser Ser Val Gly Lys Phe Ser Thr Val Asn Pro Val 
    210                 215                 220                 


Tyr Val Gly Asn Val Ala Trp Ala His Ile Leu Ala Leu Arg Ala Leu 
225                 230                 235                 240 


Gln Asp Pro Lys Lys Ala Pro Ser Ile Arg Gly Gln Phe Tyr Tyr Ile 
                245                 250                 255     


Ser Asp Asp Thr Pro His Gln Ser Tyr Asp Asn Leu Asn Tyr Thr Leu 
            260                 265                 270         


Ser Lys Glu Phe Gly Leu Arg Leu Asp Ser Arg Trp Ser Phe Pro Leu 
        275                 280                 285             


Ser Leu Met Tyr Trp Ile Gly Phe Leu Leu Glu Ile Val Ser Phe Leu 
    290                 295                 300                 


Leu Arg Pro Ile Tyr Thr Tyr Arg Pro Pro Phe Asn Arg His Ile Val 
305                 310                 315                 320 


Thr Leu Ser Asn Ser Val Phe Thr Phe Ser Tyr Lys Lys Ala Gln Arg 
                325                 330                 335     


Asp Leu Ala Tyr Lys Pro Leu Tyr Ser Trp Glu Glu Ala Lys Gln Lys 
            340                 345                 350         


Thr Val Glu Trp Val Gly Ser Leu Val Asp Arg His Lys Glu Thr Leu 
        355                 360                 365             


Lys Ser Lys Thr Gln 
    370             


<210>  18
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  19
<211>  1186
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Glu Pro Pro Gly Lys Pro Leu Ser Cys Glu Glu Lys Glu Lys 
1               5                   10                  15      


Leu Lys Glu Lys Leu Ala Phe Leu Lys Arg Glu Tyr Ser Lys Thr Leu 
            20                  25                  30          


Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Lys Ile Lys His Ser Ile 
        35                  40                  45              


Lys Lys Thr Val Glu Glu Gln Asp Cys Leu Ser Gln Gln Asp Leu Ser 
    50                  55                  60                  


Pro Gln Leu Lys His Ser Glu Pro Lys Asn Lys Ile Cys Val Tyr Asp 
65                  70                  75                  80  


Lys Leu His Ile Lys Thr His Leu Asp Glu Glu Thr Gly Glu Lys Thr 
                85                  90                  95      


Ser Ile Thr Leu Asp Val Gly Pro Glu Ser Phe Asn Pro Gly Asp Gly 
            100                 105                 110         


Pro Gly Gly Leu Pro Ile Gln Arg Thr Asp Asp Thr Gln Glu His Phe 
        115                 120                 125             


Pro His Arg Val Ser Asp Pro Ser Gly Glu Gln Lys Gln Lys Leu Pro 
    130                 135                 140                 


Ser Arg Arg Lys Lys Gln Gln Lys Arg Thr Phe Ile Ser Gln Glu Arg 
145                 150                 155                 160 


Asp Cys Val Phe Gly Thr Asp Ser Leu Arg Leu Ser Gly Lys Arg Leu 
                165                 170                 175     


Lys Glu Gln Glu Glu Ile Ser Ser Lys Asn Pro Ala Arg Ser Pro Val 
            180                 185                 190         


Thr Glu Ile Arg Thr His Leu Leu Ser Leu Lys Ser Glu Leu Pro Asp 
        195                 200                 205             


Ser Pro Glu Pro Val Thr Glu Ile Asn Glu Asp Ser Val Leu Ile Pro 
    210                 215                 220                 


Pro Thr Ala Gln Pro Glu Lys Gly Val Asp Thr Phe Leu Arg Arg Pro 
225                 230                 235                 240 


Asn Phe Thr Arg Ala Thr Thr Val Pro Leu Gln Thr Leu Ser Asp Ser 
                245                 250                 255     


Gly Ser Ser Gln His Leu Glu His Ile Pro Pro Lys Gly Ser Ser Glu 
            260                 265                 270         


Leu Thr Thr His Asp Leu Lys Asn Ile Arg Phe Thr Ser Pro Val Ser 
        275                 280                 285             


Leu Glu Ala Gln Gly Lys Lys Met Thr Val Ser Thr Asp Asn Leu Leu 
    290                 295                 300                 


Val Asn Lys Ala Ile Ser Lys Ser Gly Gln Leu Pro Thr Ser Ser Asn 
305                 310                 315                 320 


Leu Glu Ala Asn Ile Ser Cys Ser Leu Asn Glu Leu Thr Tyr Asn Asn 
                325                 330                 335     


Leu Pro Ala Asn Glu Asn Gln Asn Leu Lys Glu Gln Asn Gln Thr Glu 
            340                 345                 350         


Lys Ser Leu Lys Ser Pro Ser Asp Thr Leu Asp Gly Arg Asn Glu Asn 
        355                 360                 365             


Leu Gln Glu Ser Glu Ile Leu Ser Gln Pro Lys Ser Leu Ser Leu Glu 
    370                 375                 380                 


Ala Thr Ser Pro Leu Ser Ala Glu Lys His Ser Cys Thr Val Pro Glu 
385                 390                 395                 400 


Gly Leu Leu Phe Pro Ala Glu Tyr Tyr Val Arg Thr Thr Arg Ser Met 
                405                 410                 415     


Ser Asn Cys Gln Arg Lys Val Ala Val Glu Ala Val Ile Gln Ser His 
            420                 425                 430         


Leu Asp Val Lys Lys Lys Gly Phe Lys Asn Lys Asn Lys Asp Ala Ser 
        435                 440                 445             


Lys Asn Leu Asn Leu Ser Asn Glu Glu Thr Asp Gln Ser Glu Ile Arg 
    450                 455                 460                 


Met Ser Gly Thr Cys Thr Gly Gln Pro Ser Ser Arg Thr Ser Gln Lys 
465                 470                 475                 480 


Leu Leu Ser Leu Thr Lys Val Ser Ser Pro Ala Gly Pro Thr Glu Asp 
                485                 490                 495     


Asn Asp Leu Ser Arg Lys Ala Val Ala Gln Ala Pro Gly Arg Arg Tyr 
            500                 505                 510         


Thr Gly Lys Arg Lys Ser Ala Cys Thr Pro Ala Ser Asp His Cys Glu 
        515                 520                 525             


Pro Leu Leu Pro Thr Ser Ser Leu Ser Ile Val Asn Arg Ser Lys Glu 
    530                 535                 540                 


Glu Val Thr Ser His Lys Tyr Gln His Glu Lys Leu Phe Ile Gln Val 
545                 550                 555                 560 


Lys Gly Lys Lys Ser Arg His Gln Lys Glu Asp Ser Leu Ser Trp Ser 
                565                 570                 575     


Asn Ser Ala Tyr Leu Ser Leu Asp Asp Asp Ala Phe Thr Ala Pro Phe 
            580                 585                 590         


His Arg Asp Gly Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu Ser 
        595                 600                 605             


Ile Thr Asp Phe Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys Leu 
    610                 615                 620                 


Glu Lys Val Lys Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu Ser 
625                 630                 635                 640 


Lys Met Phe Gly Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe Pro 
                645                 650                 655     


Glu Glu Leu Ser Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu Glu 
            660                 665                 670         


Glu Asp Leu Ile Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro Asn 
        675                 680                 685             


Ser Gln Ser Gln His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu Leu 
    690                 695                 700                 


Tyr Thr Pro Leu Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro Thr 
705                 710                 715                 720 


Thr Asp Met Cys Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro Ala 
                725                 730                 735     


Phe Gly Pro Gln Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala Gly 
            740                 745                 750         


Arg Thr Cys Cys Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val Cys 
        755                 760                 765             


Leu Ala Ser Asp Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala Lys 
    770                 775                 780                 


Pro His Thr Thr Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr Cys 
785                 790                 795                 800 


Asp Cys Asp Ser Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser Phe 
                805                 810                 815     


Thr Phe Lys Glu Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu His 
            820                 825                 830         


Lys His Ser Val Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser Asp 
        835                 840                 845             


Ser Ile Asn Pro Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn Pro 
    850                 855                 860                 


Ser Gly Ser Cys Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg Ala 
865                 870                 875                 880 


Gly Cys Lys Glu Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val Ser 
                885                 890                 895     


Leu Trp Lys Ala Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr Trp 
            900                 905                 910         


His Phe Ala Glu Val Pro Val Leu Gln Ile Val Pro Val Pro Asp Val 
        915                 920                 925             


Tyr Asn Leu Val Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu Ile 
    930                 935                 940                 


Arg Ala Leu Phe Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val Leu 
945                 950                 955                 960 


Leu Lys Ser Gly Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg Arg 
                965                 970                 975     


Leu Val Ser Ser Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val Met 
            980                 985                 990         


Thr Phe Ala Glu Asp Gly Gly Gly  Lys Glu Asn Gln Phe  Leu Met Pro 
        995                 1000                 1005             


Pro Glu  Glu Thr Ile Leu Thr  Phe Ala Glu Val Gln  Gly Met Gln 
    1010                 1015                 1020             


Glu Ala  Leu Leu Gly Thr Thr  Ile Met Asn Asn Ile  Val Ile Trp 
    1025                 1030                 1035             


Asn Leu  Lys Thr Gly Gln Leu  Leu Lys Lys Met His  Ile Asp Asp 
    1040                 1045                 1050             


Ser Tyr  Gln Ala Ser Val Cys  His Lys Ala Tyr Ser  Glu Met Gly 
    1055                 1060                 1065             


Leu Leu  Phe Ile Val Leu Ser  His Pro Cys Ala Lys  Glu Ser Glu 
    1070                 1075                 1080             


Ser Leu  Arg Ser Pro Val Phe  Gln Leu Ile Val Ile  Asn Pro Lys 
    1085                 1090                 1095             


Thr Thr  Leu Ser Val Gly Val  Met Leu Tyr Cys Leu  Pro Pro Gly 
    1100                 1105                 1110             


Gln Ala  Gly Arg Phe Leu Glu  Gly Asp Val Lys Asp  His Cys Ala 
    1115                 1120                 1125             


Ala Ala  Ile Leu Thr Ser Gly  Thr Ile Ala Ile Trp  Asp Leu Leu 
    1130                 1135                 1140             


Leu Gly  Gln Cys Thr Ala Leu  Leu Pro Pro Val Ser  Asp Gln His 
    1145                 1150                 1155             


Trp Ser  Phe Val Lys Trp Ser  Gly Thr Asp Ser His  Leu Leu Ala 
    1160                 1165                 1170             


Gly Gln  Lys Asp Gly Asn Ile  Phe Val Tyr His Tyr  Ser 
    1175                 1180                 1185     


<210>  20
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Asp Ser Trp Val Pro Asn Ser Ala Ser Gly Gln Asp Pro Gly 
1               5                   10                  15      


Gly Arg Arg Arg Ala Trp Ala Glu Leu Leu Ala Gly Arg Val Lys Arg 
            20                  25                  30          


Glu Lys Tyr Asn Pro Glu Arg Ala Gln Lys Leu Lys Glu Ser Ala Val 
        35                  40                  45              


Arg Leu Leu Arg Ser His Gln Asp Leu Asn Ala Leu Leu Leu Glu Val 
    50                  55                  60                  


Glu Gly Pro Leu Cys Lys Lys Leu Ser Leu Ser Lys Val Ile Asp Cys 
65                  70                  75                  80  


Asp Ser Ser Glu Ala Tyr Ala Asn His Ser Ser Ser Phe Ile Gly Ser 
                85                  90                  95      


Ala Leu Gln Asp Gln Ala Ser Arg Leu Gly Val Pro Val Gly Ile Leu 
            100                 105                 110         


Ser Ala Gly Met Val Ala Ser Ser Val Gly Gln Ile Cys Thr Ala Pro 
        115                 120                 125             


Ala Glu Thr Ser His Pro Val Leu Leu Thr Val Glu Gln Arg Lys Lys 
    130                 135                 140                 


Leu Ser Ser Leu Leu Glu Phe Ala Gln Tyr Leu Leu Ala His Ser Met 
145                 150                 155                 160 


Phe Ser Arg Leu Ser Phe Cys Gln Glu Leu Trp Lys Ile Gln Ser Ser 
                165                 170                 175     


Leu Leu Leu Glu Ala Val Trp His Leu His Val Gln Gly Ile Val Ser 
            180                 185                 190         


Leu Gln Glu Leu Leu Glu Ser His Pro Asp Met His Ala Val Gly Ser 
        195                 200                 205             


Trp Leu Phe Arg Asn Leu Cys Cys Leu Cys Glu Gln Met Glu Ala Ser 
    210                 215                 220                 


Cys Gln His Ala Asp Val Ala Arg Ala Met Leu Ser Asp Phe Val Gln 
225                 230                 235                 240 


Met Phe Val Leu Arg Gly Phe Gln Lys Asn Ser Asp Leu Arg Arg Thr 
                245                 250                 255     


Val Glu Pro Glu Lys Met Pro Gln Val Thr Val Asp Val Leu Gln Arg 
            260                 265                 270         


Met Leu Ile Phe Ala Leu Asp Ala Leu Ala Ala Gly Val Gln Glu Glu 
        275                 280                 285             


Ser Ser Thr His Lys Ile Val Arg Cys Trp Phe Gly Val Phe Ser Gly 
    290                 295                 300                 


His Thr Leu Gly Ser Val Ile Ser Thr Asp Pro Leu Lys Arg Phe Phe 
305                 310                 315                 320 


Ser His Thr Leu Thr Gln Ile Leu Thr His Ser Pro Val Leu Lys Ala 
                325                 330                 335     


Ser Asp Ala Val Gln Met Gln Arg Glu Trp Ser Phe Ala Arg Thr His 
            340                 345                 350         


Pro Leu Leu Thr Ser Leu Tyr Arg Arg Leu Phe Val Met Leu Ser Ala 
        355                 360                 365             


Glu Glu Leu Val Gly His Leu Gln Glu Val Leu Glu Thr Gln Glu Val 
    370                 375                 380                 


His Trp Gln Arg Val Leu Ser Phe Val Ser Ala Leu Val Val Cys Phe 
385                 390                 395                 400 


Pro Glu Ala Gln Gln Leu Leu Glu Asp Trp Val Ala Arg Leu Met Ala 
                405                 410                 415     


Gln Ala Phe Glu Ser Cys Gln Leu Asp Ser Met Val Thr Ala Phe Leu 
            420                 425                 430         


Val Val Arg Gln Ala Ala Leu Glu Gly Pro Ser Ala Phe Leu Ser Tyr 
        435                 440                 445             


Ala Asp Trp Phe Lys Ala Ser Phe Gly Ser Thr Arg Gly Tyr His Gly 
    450                 455                 460                 


Cys Ser Lys Lys Ala Leu Val Phe Leu Phe Thr Phe Leu Ser Glu Leu 
465                 470                 475                 480 


Val Pro Phe Glu Ser Pro Arg Tyr Leu Gln Val His Ile Leu His Pro 
                485                 490                 495     


Pro Leu Val Pro Gly Lys Tyr Arg Ser Leu Leu Thr Asp Tyr Ile Ser 
            500                 505                 510         


Leu Ala Lys Thr Arg Leu Ala Asp Leu Lys Val Ser Ile Glu Asn Met 
        515                 520                 525             


Gly Leu Tyr Glu Asp Leu Ser Ser Ala Gly Asp Ile Thr Glu Pro His 
    530                 535                 540                 


Ser Gln Ala Leu Gln Asp Val Glu Lys Ala Ile Met Val Phe Glu His 
545                 550                 555                 560 


Thr Gly Asn Ile Pro Val Thr Val Met Glu Ala Ser Ile Phe Arg Arg 
                565                 570                 575     


Pro Tyr Tyr Val Ser His Phe Leu Pro Ala Leu Leu Thr Pro Arg Val 
            580                 585                 590         


Leu Pro Lys Val Pro Asp Ser Arg Val Ala Phe Ile Glu Ser Leu Lys 
        595                 600                 605             


Arg Ala Asp Lys Ile Pro Pro Ser Leu Tyr Ser Thr Tyr Cys Gln Ala 
    610                 615                 620                 


Cys Ser Ala Ala Glu Glu Lys Pro Glu Asp Ala Ala Leu Gly Val Arg 
625                 630                 635                 640 


Ala Glu Pro Asn Ser Ala Glu Glu Pro Leu Gly Gln Leu Thr Ala Ala 
                645                 650                 655     


Leu Gly Glu Leu Arg Ala Ser Met Thr Asp Pro Ser Gln Arg Asp Val 
            660                 665                 670         


Ile Ser Ala Gln Val Ala Val Ile Ser Glu Arg Leu Arg Ala Val Leu 
        675                 680                 685             


Gly His Asn Glu Asp Asp Ser Ser Val Glu Ile Ser Lys Ile Gln Leu 
    690                 695                 700                 


Ser Ile Asn Thr Pro Arg Leu Glu Pro Arg Glu His Met Ala Val Asp 
705                 710                 715                 720 


Leu Leu Leu Thr Ser Phe Cys Gln Asn Leu Met Ala Ala Ser Ser Val 
                725                 730                 735     


Ala Pro Pro Glu Arg Gln Gly Pro Trp Ala Ala Leu Phe Val Arg Thr 
            740                 745                 750         


Met Cys Gly Arg Val Leu Pro Ala Val Leu Thr Arg Leu Cys Gln Leu 
        755                 760                 765             


Leu Arg His Gln Gly Pro Ser Leu Ser Ala Pro His Val Leu Gly Leu 
    770                 775                 780                 


Ala Ala Leu Ala Val His Leu Gly Glu Ser Arg Ser Ala Leu Pro Glu 
785                 790                 795                 800 


Val Asp Val Gly Pro Pro Ala Pro Gly Ala Gly Leu Pro Val Pro Ala 
                805                 810                 815     


Leu Phe Asp Ser Leu Leu Thr Cys Arg Thr Arg Asp Ser Leu Phe Phe 
            820                 825                 830         


Cys Leu Lys Phe Cys Thr Ala Ala Ile Ser Tyr Ser Leu Cys Lys Phe 
        835                 840                 845             


Ser Ser Gln Ser Arg Asp Thr Leu Cys Ser Cys Leu Ser Pro Gly Leu 
    850                 855                 860                 


Ile Lys Lys Phe Gln Phe Leu Met Phe Arg Leu Phe Ser Glu Ala Arg 
865                 870                 875                 880 


Gln Pro Leu Ser Glu Glu Asp Val Ala Ser Leu Ser Trp Arg Pro Leu 
                885                 890                 895     


His Leu Pro Ser Ala Asp Trp Gln Arg Ala Ala Leu Ser Leu Trp Thr 
            900                 905                 910         


His Arg Thr Phe Arg Glu Val Leu Lys Glu Glu Asp Val His Leu Thr 
        915                 920                 925             


Tyr Gln Asp Trp Leu His Leu Glu Leu Glu Ile Gln Pro Glu Ala Asp 
    930                 935                 940                 


Ala Leu Ser Asp Thr Glu Arg Gln Asp Phe His Gln Trp Ala Ile His 
945                 950                 955                 960 


Glu His Phe Leu Pro Glu Ser Ser Ala Ser Gly Gly Cys Asp Gly Asp 
                965                 970                 975     


Leu Gln Ala Ala Cys Thr Ile Leu Val Asn Ala Leu Met Asp Phe His 
            980                 985                 990         


Gln Ser Ser Arg Ser Tyr Asp His  Ser Glu Asn Ser Asp  Leu Val Phe 
        995                 1000                 1005             


Gly Gly  Arg Thr Gly Asn Glu  Asp Ile Ile Ser Arg  Leu Gln Glu 
    1010                 1015                 1020             


Met Val  Ala Asp Leu Glu Leu  Gln Gln Asp Leu Ile  Val Pro Leu 
    1025                 1030                 1035             


Gly His  Thr Pro Ser Gln Glu  His Phe Leu Phe Glu  Ile Phe Arg 
    1040                 1045                 1050             


Arg Arg  Leu Gln Ala Leu Thr  Ser Gly Trp Ser Val  Ala Ala Ser 
    1055                 1060                 1065             


Leu Gln  Arg Gln Arg Glu Leu  Leu Met Tyr Lys Arg  Ile Leu Leu 
    1070                 1075                 1080             


Arg Leu  Pro Ser Ser Val Leu  Cys Gly Ser Ser Phe  Gln Ala Glu 
    1085                 1090                 1095             


Gln Pro  Ile Thr Ala Arg Cys  Glu Gln Phe Phe His  Leu Val Asn 
    1100                 1105                 1110             


Ser Glu  Met Arg Asn Phe Cys  Ser His Gly Gly Ala  Leu Thr Gln 
    1115                 1120                 1125             


Asp Ile  Thr Ala His Phe Phe  Arg Gly Leu Leu Asn  Ala Cys Leu 
    1130                 1135                 1140             


Arg Ser  Arg Asp Pro Ser Leu  Met Val Asp Phe Ile  Leu Ala Lys 
    1145                 1150                 1155             


Cys Gln  Thr Lys Cys Pro Leu  Ile Leu Thr Ser Ala  Leu Val Trp 
    1160                 1165                 1170             


Trp Pro  Ser Leu Glu Pro Val  Leu Leu Cys Arg Trp  Arg Arg His 
    1175                 1180                 1185             


Cys Gln  Ser Pro Leu Pro Arg  Glu Leu Gln Lys Leu  Gln Glu Gly 
    1190                 1195                 1200             


Arg Gln  Phe Ala Ser Asp Phe  Leu Ser Pro Glu Ala  Ala Ser Pro 
    1205                 1210                 1215             


Ala Pro  Asn Pro Asp Trp Leu  Ser Ala Ala Ala Leu  His Phe Ala 
    1220                 1225                 1230             


Ile Gln  Gln Val Arg Glu Glu  Asn Ile Arg Lys Gln  Leu Lys Lys 
    1235                 1240                 1245             


Leu Asp  Cys Glu Arg Glu Glu  Leu Leu Val Phe Leu  Phe Phe Phe 
    1250                 1255                 1260             


Ser Leu  Met Gly Leu Leu Ser  Ser His Leu Thr Ser  Asn Ser Thr 
    1265                 1270                 1275             


Thr Asp  Leu Pro Lys Ala Phe  His Val Cys Ala Ala  Ile Leu Glu 
    1280                 1285                 1290             


Cys Leu  Glu Lys Arg Lys Ile  Ser Trp Leu Ala Leu  Phe Gln Leu 
    1295                 1300                 1305             


Thr Glu  Ser Asp Leu Arg Leu  Gly Arg Leu Leu Leu  Arg Val Ala 
    1310                 1315                 1320             


Pro Asp  Gln His Thr Arg Leu  Leu Pro Phe Ala Phe  Tyr Ser Leu 
    1325                 1330                 1335             


Leu Ser  Tyr Phe His Glu Asp  Ala Ala Ile Arg Glu  Glu Ala Phe 
    1340                 1345                 1350             


Leu His  Val Ala Val Asp Met  Tyr Leu Lys Leu Val  Gln Leu Phe 
    1355                 1360                 1365             


Val Ala  Gly Asp Thr Ser Thr  Val Ser Pro Pro Ala  Gly Arg Ser 
    1370                 1375                 1380             


Leu Glu  Leu Lys Gly Gln Gly  Asn Pro Val Glu Leu  Ile Thr Lys 
    1385                 1390                 1395             


Ala Arg  Leu Phe Leu Leu Gln  Leu Ile Pro Arg Cys  Pro Lys Lys 
    1400                 1405                 1410             


Ser Phe  Ser His Val Ala Glu  Leu Leu Ala Asp Arg  Gly Asp Cys 
    1415                 1420                 1425             


Asp Pro  Glu Val Ser Ala Ala  Leu Gln Ser Arg Gln  Gln Ala Ala 
    1430                 1435                 1440             


Pro Asp  Ala Asp Leu Ser Gln  Glu Pro His Leu Phe  
    1445                 1450                 1455 


<210>  21
<211>  1417
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Gly  Ser Lys Ser Ala Lys  Ile Gln Ser 
    1115                 1120                 1125             


Gly Ile  Phe Gly Lys Gly Ser  Ala Tyr Ser Arg His  Asn Ala Glu 
    1130                 1135                 1140             


Arg Leu  Phe Lys Lys Leu Ile  Leu Asp Lys Ile Leu  Asp Glu Asp 
    1145                 1150                 1155             


Leu Tyr  Ile Asn Ala Asn Asp  Gln Ala Ile Ala Tyr  Val Met Leu 
    1160                 1165                 1170             


Gly Asn  Lys Ala Gln Thr Val  Leu Asn Gly Asn Leu  Lys Val Asp 
    1175                 1180                 1185             


Phe Met  Glu Thr Glu Asn Ser  Ser Ser Val Lys Lys  Gln Lys Ala 
    1190                 1195                 1200             


Leu Val  Ala Lys Val Ser Gln  Arg Glu Glu Met Val  Lys Lys Cys 
    1205                 1210                 1215             


Leu Gly  Glu Leu Thr Glu Val  Cys Lys Ser Leu Gly  Lys Val Phe 
    1220                 1225                 1230             


Gly Val  His Tyr Phe Asn Ile  Phe Asn Thr Val Thr  Leu Lys Lys 
    1235                 1240                 1245             


Leu Ala  Glu Ser Leu Ser Ser  Asp Pro Glu Val Leu  Leu Gln Ile 
    1250                 1255                 1260             


Asp Gly  Val Thr Glu Asp Lys  Leu Glu Lys Tyr Gly  Ala Glu Val 
    1265                 1270                 1275             


Ile Ser  Val Leu Gln Lys Tyr  Ser Glu Trp Thr Ser  Pro Ala Glu 
    1280                 1285                 1290             


Asp Ser  Ser Pro Gly Ile Ser  Leu Ser Ser Ser Arg  Gly Pro Gly 
    1295                 1300                 1305             


Arg Ser  Ala Ala Glu Glu Leu  Asp Glu Glu Ile Pro  Val Ser Ser 
    1310                 1315                 1320             


His Tyr  Phe Ala Ser Lys Thr  Arg Asn Glu Arg Lys  Arg Lys Lys 
    1325                 1330                 1335             


Met Pro  Ala Ser Gln Arg Ser  Lys Arg Arg Lys Thr  Ala Ser Ser 
    1340                 1345                 1350             


Gly Ser  Lys Ala Lys Gly Gly  Ser Ala Thr Cys Arg  Lys Ile Ser 
    1355                 1360                 1365             


Ser Lys  Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
    1370                 1375                 1380             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1385                 1390                 1395             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1400                 1405                 1410             


Tyr Ala  Phe Ser 
    1415         


<210>  22
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Ala Met Thr Leu 
1               5                   10                  15      


Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro Ser Phe Pro 
            20                  25                  30          


Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr Thr Gln 
        35                  40                  45              


Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu Arg Arg 
    50                  55                  60                  


Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu Trp Asn Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys Asn Tyr Arg 
                85                  90                  95      


His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys Gly Glu Asn 
            100                 105                 110         


Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala Ile Gln Ser 
        115                 120                 125             


Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly Pro Lys Thr 
    130                 135                 140                 


Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp Tyr Ser Ser 
145                 150                 155                 160 


Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln Lys Val Leu 
                165                 170                 175     


Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn Trp Ala Asn 
            180                 185                 190         


Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala Ser Cys Pro 
        195                 200                 205             


Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys Tyr Glu Asp 
    210                 215                 220                 


Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr Cys Lys His 
225                 230                 235                 240 


Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys Ser Asn Ser 
                245                 250                 255     


Ile Tyr 
        


<210>  23
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Val Leu Ala Gln Ser Arg Val Ser Ala Gly Val Gly Ser Pro His 
1               5                   10                  15      


Cys Ser Gly Ser Gly Gly Gly Gly Ser Asp Ser Phe Pro Trp Pro Ala 
            20                  25                  30          


Ser His Pro Gly Asn Pro Gln Cys Ser Phe Ser Thr Ala Phe Leu Ala 
        35                  40                  45              


Ser Pro Arg Leu Ser Arg Gly Thr Leu Ala Tyr Leu Pro Pro Ala Pro 
    50                  55                  60                  


Trp Ser Ser Leu Ala Thr Pro Ser Ala Leu Leu Gly Ser Ser Cys Ala 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Ala Arg Cys Pro Gln Pro Arg Ala Leu Ser Pro 
                85                  90                  95      


Glu Leu Gly Thr Lys Ala Gly Pro Arg Arg Pro His Arg Trp Glu Leu 
            100                 105                 110         


Pro Arg Ser Pro Ser Gln Gly Ala Gln Gly Pro Ala Pro Arg Arg Arg 
        115                 120                 125             


Leu Leu Glu Thr Met Lys Gly Ile Val Ala Ala Ser Gly Ser Glu Thr 
    130                 135                 140                 


Glu Asp Glu Asp Ser Met Asp Ile Pro Leu Asp Leu Ser Ser Ser Ala 
145                 150                 155                 160 


Gly Ser Gly Lys Arg Arg Arg Arg Gly Asn Leu Pro Lys Glu Ser Val 
                165                 170                 175     


Gln Ile Leu Arg Asp Trp Leu Tyr Glu His Arg Tyr Asn Ala Tyr Pro 
            180                 185                 190         


Ser Glu Gln Glu Lys Ala Leu Leu Ser Gln Gln Thr His Leu Ser Thr 
        195                 200                 205             


Leu Gln Val Cys Asn Trp Phe Ile Asn Ala Arg Arg Arg Leu Leu Pro 
    210                 215                 220                 


Asp Met Leu Arg Lys Asp Gly Lys Asp Pro Asn Gln Phe Thr Ile Ser 
225                 230                 235                 240 


Arg Arg Gly Ala Lys Ile Ser Glu Thr Ser Ser Val Glu Ser Val Met 
                245                 250                 255     


Gly Ile Lys Asn Phe Met Pro Ala Leu Glu Glu Thr Pro Phe His Ser 
            260                 265                 270         


Cys Thr Ala Gly Pro Asn Pro Thr Leu Gly Arg Pro Leu Ser Pro Lys 
        275                 280                 285             


Pro Ser Ser Pro Gly Ser Val Leu Ala Arg Pro Ser Val Ile Cys His 
    290                 295                 300                 


Thr Thr Val Thr Ala Leu Lys Asp Val Pro Phe Ser Leu Cys Gln Ser 
305                 310                 315                 320 


Val Gly Val Gly Gln Asn Thr Asp Ile Gln Gln Ile Ala Ala Lys Asn 
                325                 330                 335     


Phe Thr Asp Thr Ser Leu Met Tyr Pro Glu Asp Thr Cys Lys Ser Gly 
            340                 345                 350         


Pro Ser Thr Asn Thr Gln Ser Gly Leu Phe Asn Thr Pro Pro Pro Thr 
        355                 360                 365             


Pro Pro Asp Leu Asn Gln Asp Phe Ser Gly Phe Gln Leu Leu Val Asp 
    370                 375                 380                 


Val Ala Leu Lys Arg Ala Ala Glu Met Glu Leu Gln Ala Lys Leu Thr 
385                 390                 395                 400 


Ala 
    


<210>  24
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  25
<211>  826
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Trp Ala Leu Cys Ser Leu Leu Arg Ser Ala Ala Gly Arg Thr Met 
1               5                   10                  15      


Ser Gln Gly Arg Thr Ile Ser Gln Ala Pro Ala Arg Arg Glu Arg Pro 
            20                  25                  30          


Arg Lys Asp Pro Leu Arg His Leu Arg Thr Arg Glu Lys Arg Gly Pro 
        35                  40                  45              


Ser Gly Cys Ser Gly Gly Pro Asn Thr Val Tyr Leu Gln Val Val Ala 
    50                  55                  60                  


Ala Gly Ser Arg Asp Ser Gly Ala Ala Leu Tyr Val Phe Ser Glu Phe 
65                  70                  75                  80  


Asn Arg Tyr Leu Phe Asn Cys Gly Glu Gly Val Gln Arg Leu Met Gln 
                85                  90                  95      


Glu His Lys Leu Lys Val Ala Arg Leu Asp Asn Ile Phe Leu Thr Arg 
            100                 105                 110         


Met His Trp Ser Asn Val Gly Gly Leu Ser Gly Met Ile Leu Thr Leu 
        115                 120                 125             


Lys Glu Thr Gly Leu Pro Lys Cys Val Leu Ser Gly Pro Pro Gln Leu 
    130                 135                 140                 


Glu Lys Tyr Leu Glu Ala Ile Lys Ile Phe Ser Gly Pro Leu Lys Gly 
145                 150                 155                 160 


Ile Glu Leu Ala Val Arg Pro His Ser Ala Pro Glu Tyr Glu Asp Glu 
                165                 170                 175     


Thr Met Thr Val Tyr Gln Ile Pro Ile His Ser Glu Gln Arg Arg Gly 
            180                 185                 190         


Lys His Gln Pro Trp Gln Ser Pro Glu Arg Pro Leu Ser Arg Leu Ser 
        195                 200                 205             


Pro Glu Arg Ser Ser Asp Ser Glu Ser Asn Glu Asn Glu Pro His Leu 
    210                 215                 220                 


Pro His Gly Val Ser Gln Arg Arg Gly Val Arg Asp Ser Ser Leu Val 
225                 230                 235                 240 


Val Ala Phe Ile Cys Lys Leu His Leu Lys Arg Gly Asn Phe Leu Val 
                245                 250                 255     


Leu Lys Ala Lys Glu Met Gly Leu Pro Val Gly Thr Ala Ala Ile Ala 
            260                 265                 270         


Pro Ile Ile Ala Ala Val Lys Asp Gly Lys Ser Ile Thr His Glu Gly 
        275                 280                 285             


Arg Glu Ile Leu Ala Glu Glu Leu Cys Thr Pro Pro Asp Pro Gly Ala 
    290                 295                 300                 


Ala Phe Val Val Val Glu Cys Pro Asp Glu Ser Phe Ile Gln Pro Ile 
305                 310                 315                 320 


Cys Glu Asn Ala Thr Phe Gln Arg Tyr Gln Gly Lys Ala Asp Ala Pro 
                325                 330                 335     


Val Ala Leu Val Val His Met Ala Pro Ala Ser Val Leu Val Asp Ser 
            340                 345                 350         


Arg Tyr Gln Gln Trp Met Glu Arg Phe Gly Pro Asp Thr Gln His Leu 
        355                 360                 365             


Val Leu Asn Glu Asn Cys Ala Ser Val His Asn Leu Arg Ser His Lys 
    370                 375                 380                 


Ile Gln Thr Gln Leu Asn Leu Ile His Pro Asp Ile Phe Pro Leu Leu 
385                 390                 395                 400 


Thr Ser Phe Arg Cys Lys Lys Glu Gly Pro Thr Leu Ser Val Pro Met 
                405                 410                 415     


Val Gln Gly Glu Cys Leu Leu Lys Tyr Gln Leu Arg Pro Arg Arg Glu 
            420                 425                 430         


Trp Gln Arg Asp Ala Ile Ile Thr Cys Asn Pro Glu Glu Phe Ile Val 
        435                 440                 445             


Glu Ala Leu Gln Leu Pro Asn Phe Gln Gln Ser Val Gln Glu Tyr Arg 
    450                 455                 460                 


Arg Ser Ala Gln Asp Gly Pro Ala Pro Ala Glu Lys Arg Ser Gln Tyr 
465                 470                 475                 480 


Pro Glu Ile Ile Phe Leu Gly Thr Gly Ser Ala Ile Pro Met Lys Ile 
                485                 490                 495     


Arg Asn Val Ser Ala Thr Leu Val Asn Ile Ser Pro Asp Thr Ser Leu 
            500                 505                 510         


Leu Leu Asp Cys Gly Glu Gly Thr Phe Gly Gln Leu Cys Arg His Tyr 
        515                 520                 525             


Gly Asp Gln Val Asp Arg Val Leu Gly Thr Leu Ala Ala Val Phe Val 
    530                 535                 540                 


Ser His Leu His Ala Asp His His Thr Gly Leu Pro Ser Ile Leu Leu 
545                 550                 555                 560 


Gln Arg Glu Arg Ala Leu Ala Ser Leu Gly Lys Pro Leu His Pro Leu 
                565                 570                 575     


Leu Val Val Ala Pro Asn Gln Leu Lys Ala Trp Leu Gln Gln Tyr His 
            580                 585                 590         


Asn Gln Cys Gln Glu Val Leu His His Ile Ser Met Ile Pro Ala Lys 
        595                 600                 605             


Cys Leu Gln Glu Gly Ala Glu Ile Ser Ser Pro Ala Val Glu Arg Leu 
    610                 615                 620                 


Ile Ser Ser Leu Leu Arg Thr Cys Asp Leu Glu Glu Phe Gln Thr Cys 
625                 630                 635                 640 


Leu Val Arg His Cys Lys His Ala Phe Gly Cys Ala Leu Val His Thr 
                645                 650                 655     


Ser Gly Trp Lys Val Val Tyr Ser Gly Asp Thr Met Pro Cys Glu Ala 
            660                 665                 670         


Leu Val Arg Met Gly Lys Asp Ala Thr Leu Leu Ile His Glu Ala Thr 
        675                 680                 685             


Leu Glu Asp Gly Leu Glu Glu Glu Ala Val Glu Lys Thr His Ser Thr 
    690                 695                 700                 


Thr Ser Gln Ala Ile Ser Val Gly Met Arg Met Asn Ala Glu Phe Ile 
705                 710                 715                 720 


Met Leu Asn His Phe Ser Gln Arg Tyr Ala Lys Val Pro Leu Phe Ser 
                725                 730                 735     


Pro Asn Phe Ser Glu Lys Val Gly Val Ala Phe Asp His Met Lys Val 
            740                 745                 750         


Cys Phe Gly Asp Phe Pro Thr Met Pro Lys Leu Ile Pro Pro Leu Lys 
        755                 760                 765             


Ala Leu Phe Ala Gly Asp Ile Glu Glu Met Glu Glu Arg Arg Glu Lys 
    770                 775                 780                 


Arg Glu Leu Arg Gln Val Arg Ala Ala Leu Leu Ser Arg Glu Leu Ala 
785                 790                 795                 800 


Gly Gly Leu Glu Asp Gly Glu Pro Gln Gln Lys Arg Ala His Thr Glu 
                805                 810                 815     


Glu Pro Gln Ala Lys Lys Val Arg Ala Gln 
            820                 825     


<210>  26
<211>  2036
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ala Val Thr Met Ser Val Pro Gly Arg Lys Ala Pro Pro Arg 
1               5                   10                  15      


Pro Gly Pro Val Pro Glu Ala Ala Gln Pro Phe Leu Phe Thr Pro Arg 
            20                  25                  30          


Gly Pro Ser Ala Gly Gly Gly Pro Gly Ser Gly Thr Ser Pro Gln Val 
        35                  40                  45              


Glu Trp Thr Ala Arg Arg Leu Val Trp Val Pro Ser Glu Leu His Gly 
    50                  55                  60                  


Phe Glu Ala Ala Ala Leu Arg Asp Glu Gly Glu Glu Glu Ala Glu Val 
65                  70                  75                  80  


Glu Leu Ala Glu Ser Gly Arg Arg Leu Arg Leu Pro Arg Asp Gln Ile 
                85                  90                  95      


Gln Arg Met Asn Pro Pro Lys Phe Ser Lys Ala Glu Asp Met Ala Glu 
            100                 105                 110         


Leu Thr Cys Leu Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg 
        115                 120                 125             


Tyr Tyr Ser Gly Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val 
    130                 135                 140                 


Ile Asn Pro Tyr Lys Gln Leu Pro Ile Tyr Thr Glu Ala Ile Val Glu 
145                 150                 155                 160 


Met Tyr Arg Gly Lys Lys Arg His Glu Val Pro Pro His Val Tyr Ala 
                165                 170                 175     


Val Thr Glu Gly Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln 
            180                 185                 190         


Ser Ile Leu Cys Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr 
        195                 200                 205             


Lys Lys Val Ile Gln Tyr Leu Ala His Val Ala Ser Ser Pro Lys Gly 
    210                 215                 220                 


Arg Lys Glu Pro Gly Val Pro Ala Ser Val Ser Thr Val Ser Tyr Gly 
225                 230                 235                 240 


Glu Leu Glu Arg Gln Leu Leu Gln Ala Asn Pro Ile Leu Glu Ala Phe 
                245                 250                 255     


Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser Arg Phe Gly Lys 
            260                 265                 270         


Phe Ile Arg Ile Asn Phe Asp Val Ala Gly Tyr Ile Val Gly Ala Asn 
        275                 280                 285             


Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Ile Arg Gln Ala Lys 
    290                 295                 300                 


Asp Glu Cys Ser Phe His Ile Phe Tyr Gln Leu Leu Gly Gly Ala Gly 
305                 310                 315                 320 


Glu Gln Leu Lys Ala Asp Leu Leu Leu Glu Pro Cys Ser His Tyr Arg 
                325                 330                 335     


Phe Leu Thr Asn Gly Pro Ser Ser Ser Pro Gly Gln Glu Arg Glu Leu 
            340                 345                 350         


Phe Gln Glu Thr Leu Glu Ser Leu Arg Val Leu Gly Phe Ser His Glu 
        355                 360                 365             


Glu Ile Ile Ser Met Leu Arg Met Val Ser Ala Val Leu Gln Phe Gly 
    370                 375                 380                 


Asn Ile Ala Leu Lys Arg Glu Arg Asn Thr Asp Gln Ala Thr Met Pro 
385                 390                 395                 400 


Asp Asn Thr Ala Ala Gln Lys Leu Cys Arg Leu Leu Gly Leu Gly Val 
                405                 410                 415     


Thr Asp Phe Ser Arg Ala Leu Leu Thr Pro Arg Ile Lys Val Gly Arg 
            420                 425                 430         


Asp Tyr Val Gln Lys Ala Gln Thr Lys Glu Gln Ala Asp Phe Ala Leu 
        435                 440                 445             


Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu Phe Arg Trp Leu Val 
    450                 455                 460                 


Leu Arg Leu Asn Arg Ala Leu Asp Arg Ser Pro Arg Gln Gly Ala Ser 
465                 470                 475                 480 


Phe Leu Gly Ile Leu Asp Ile Ala Gly Phe Glu Ile Phe Gln Leu Asn 
                485                 490                 495     


Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn Glu Lys Leu Gln Gln 
            500                 505                 510         


Leu Phe Asn His Thr Met Phe Val Leu Glu Gln Glu Glu Tyr Gln Arg 
        515                 520                 525             


Glu Gly Ile Pro Trp Thr Phe Leu Asp Phe Gly Leu Asp Leu Gln Pro 
    530                 535                 540                 


Cys Ile Asp Leu Ile Glu Arg Pro Ala Asn Pro Pro Gly Leu Leu Ala 
545                 550                 555                 560 


Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala Thr Asp Lys Ser Phe 
                565                 570                 575     


Val Glu Lys Val Ala Gln Glu Gln Gly Gly His Pro Lys Phe Gln Arg 
            580                 585                 590         


Pro Arg His Leu Arg Asp Gln Ala Asp Phe Ser Val Leu His Tyr Ala 
        595                 600                 605             


Gly Lys Val Asp Tyr Lys Ala Asn Glu Trp Leu Met Lys Asn Met Asp 
    610                 615                 620                 


Pro Leu Asn Asp Asn Val Ala Ala Leu Leu His Gln Ser Thr Asp Arg 
625                 630                 635                 640 


Leu Thr Ala Glu Ile Trp Lys Asp Glu His Gly Gly Phe Gln Gln Phe 
                645                 650                 655     


Ser Phe Leu Gly Ser Phe Pro Pro Ser Pro Pro Gly Ser Ala Glu Arg 
            660                 665                 670         


Cys Ser Ser Ala Ile Ser Pro Pro Gly Val Glu Gly Ile Val Gly Leu 
        675                 680                 685             


Glu Gln Val Ser Ser Leu Gly Asp Gly Pro Pro Gly Gly Arg Pro Arg 
    690                 695                 700                 


Arg Gly Met Phe Arg Thr Val Gly Gln Leu Tyr Lys Glu Ser Leu Ser 
705                 710                 715                 720 


Arg Leu Met Ala Thr Leu Ser Asn Thr Asn Pro Ser Phe Val Arg Cys 
                725                 730                 735     


Ile Val Pro Asn His Glu Lys Arg Ala Gly Lys Leu Glu Pro Arg Leu 
            740                 745                 750         


Val Leu Asp Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile 
        755                 760                 765             


Cys Arg Gln Gly Phe Pro Asn Arg Ile Leu Phe Gln Glu Phe Arg Gln 
    770                 775                 780                 


Arg Tyr Glu Ile Leu Thr Pro Asn Ala Ile Pro Lys Gly Phe Met Asp 
785                 790                 795                 800 


Gly Lys Gln Ala Cys Glu Lys Met Ile Gln Ala Leu Glu Leu Asp Pro 
                805                 810                 815     


Asn Leu Tyr Arg Val Gly Gln Ser Lys Ile Phe Phe Arg Ala Gly Val 
            820                 825                 830         


Leu Ala Gln Leu Glu Glu Glu Arg Asp Leu Lys Val Thr Asp Ile Ile 
        835                 840                 845             


Val Ser Phe Gln Ala Ala Ala Arg Gly Tyr Leu Ala Arg Arg Ala Phe 
    850                 855                 860                 


Gln Lys Arg Gln Gln Gln Gln Ser Ala Leu Arg Val Met Gln Arg Asn 
865                 870                 875                 880 


Cys Ala Ala Tyr Leu Lys Leu Arg His Trp Gln Trp Trp Arg Leu Phe 
                885                 890                 895     


Thr Lys Val Lys Pro Leu Leu Gln Val Thr Arg Gln Asp Glu Val Leu 
            900                 905                 910         


Gln Ala Arg Ala Gln Glu Leu Gln Lys Val Gln Glu Leu Gln Gln Gln 
        915                 920                 925             


Ser Ala Arg Glu Val Gly Glu Leu Gln Gly Arg Val Ala Gln Leu Glu 
    930                 935                 940                 


Glu Glu Arg Ala Arg Leu Ala Glu Gln Leu Arg Ala Glu Ala Glu Leu 
945                 950                 955                 960 


Cys Ala Glu Ala Glu Glu Thr Arg Gly Arg Leu Ala Ala Arg Lys Gln 
                965                 970                 975     


Glu Leu Glu Leu Val Val Ser Glu Leu Glu Ala Arg Val Gly Glu Glu 
            980                 985                 990         


Glu Glu Cys Ser Arg Gln Met Gln  Thr Glu Lys Lys Arg  Leu Gln Gln 
        995                 1000                 1005             


His Ile  Gln Glu Leu Glu Ala  His Leu Glu Ala Glu  Glu Gly Ala 
    1010                 1015                 1020             


Arg Gln  Lys Leu Gln Leu Glu  Lys Val Thr Thr Glu  Ala Lys Met 
    1025                 1030                 1035             


Lys Lys  Phe Glu Glu Asp Leu  Leu Leu Leu Glu Asp  Gln Asn Ser 
    1040                 1045                 1050             


Lys Leu  Ser Lys Glu Arg Lys  Leu Leu Glu Asp Arg  Leu Ala Glu 
    1055                 1060                 1065             


Phe Ser  Ser Gln Ala Ala Glu  Glu Glu Glu Lys Val  Lys Ser Leu 
    1070                 1075                 1080             


Asn Lys  Leu Arg Leu Lys Tyr  Glu Ala Thr Ile Ala  Asp Met Glu 
    1085                 1090                 1095             


Asp Arg  Leu Arg Lys Glu Glu  Lys Gly Arg Gln Glu  Leu Glu Lys 
    1100                 1105                 1110             


Leu Lys  Arg Arg Leu Asp Gly  Glu Ser Ser Glu Leu  Gln Glu Gln 
    1115                 1120                 1125             


Met Val  Glu Gln Gln Gln Arg  Ala Glu Glu Leu Arg  Ala Gln Leu 
    1130                 1135                 1140             


Gly Arg  Lys Glu Glu Glu Leu  Gln Ala Ala Leu Ala  Arg Ala Glu 
    1145                 1150                 1155             


Asp Glu  Gly Gly Ala Arg Ala  Gln Leu Leu Lys Ser  Leu Arg Glu 
    1160                 1165                 1170             


Ala Gln  Ala Ala Leu Ala Glu  Ala Gln Glu Asp Leu  Glu Ser Glu 
    1175                 1180                 1185             


Arg Val  Ala Arg Thr Lys Ala  Glu Lys Gln Arg Arg  Asp Leu Gly 
    1190                 1195                 1200             


Glu Glu  Leu Glu Ala Leu Arg  Gly Glu Leu Glu Asp  Thr Leu Asp 
    1205                 1210                 1215             


Ser Thr  Asn Ala Gln Gln Glu  Leu Arg Ser Lys Arg  Glu Gln Glu 
    1220                 1225                 1230             


Val Thr  Glu Leu Lys Lys Thr  Leu Glu Glu Glu Thr  Arg Ile His 
    1235                 1240                 1245             


Glu Ala  Ala Val Gln Glu Leu  Arg Gln Arg His Gly  Gln Ala Leu 
    1250                 1255                 1260             


Gly Glu  Leu Ala Glu Gln Leu  Glu Gln Ala Arg Arg  Gly Lys Gly 
    1265                 1270                 1275             


Ala Trp  Glu Lys Thr Arg Leu  Ala Leu Glu Ala Glu  Val Ser Glu 
    1280                 1285                 1290             


Leu Arg  Ala Glu Leu Ser Ser  Leu Gln Thr Ala Arg  Gln Glu Gly 
    1295                 1300                 1305             


Glu Gln  Arg Arg Arg Arg Leu  Glu Leu Gln Leu Gln  Glu Val Gln 
    1310                 1315                 1320             


Gly Arg  Ala Gly Asp Gly Glu  Arg Ala Arg Ala Glu  Ala Ala Glu 
    1325                 1330                 1335             


Lys Leu  Gln Arg Ala Gln Ala  Glu Leu Glu Asn Val  Ser Gly Ala 
    1340                 1345                 1350             


Leu Asn  Glu Ala Glu Ser Lys  Thr Ile Arg Leu Ser  Lys Glu Leu 
    1355                 1360                 1365             


Ser Ser  Thr Glu Ala Gln Leu  His Asp Ala Gln Glu  Leu Leu Gln 
    1370                 1375                 1380             


Glu Glu  Thr Arg Ala Lys Leu  Ala Leu Gly Ser Arg  Val Arg Ala 
    1385                 1390                 1395             


Met Glu  Ala Glu Ala Ala Gly  Leu Arg Glu Gln Leu  Glu Glu Glu 
    1400                 1405                 1410             


Ala Ala  Ala Arg Glu Arg Ala  Gly Arg Glu Leu Gln  Thr Ala Gln 
    1415                 1420                 1425             


Ala Gln  Leu Ser Glu Trp Arg  Arg Arg Gln Glu Glu  Glu Ala Gly 
    1430                 1435                 1440             


Ala Leu  Glu Ala Gly Glu Glu  Ala Arg Arg Arg Ala  Ala Arg Glu 
    1445                 1450                 1455             


Ala Glu  Ala Leu Thr Gln Arg  Leu Ala Glu Lys Thr  Glu Thr Val 
    1460                 1465                 1470             


Asp Arg  Leu Glu Arg Gly Arg  Arg Arg Leu Gln Gln  Glu Leu Asp 
    1475                 1480                 1485             


Asp Ala  Thr Met Asp Leu Glu  Gln Gln Arg Gln Leu  Val Ser Thr 
    1490                 1495                 1500             


Leu Glu  Lys Lys Gln Arg Lys  Phe Asp Gln Leu Leu  Ala Glu Glu 
    1505                 1510                 1515             


Lys Ala  Ala Val Leu Arg Ala  Val Glu Glu Arg Glu  Arg Ala Glu 
    1520                 1525                 1530             


Ala Glu  Gly Arg Glu Arg Glu  Ala Arg Ala Leu Ser  Leu Thr Arg 
    1535                 1540                 1545             


Ala Leu  Glu Glu Glu Gln Glu  Ala Arg Glu Glu Leu  Glu Arg Gln 
    1550                 1555                 1560             


Asn Arg  Ala Leu Arg Ala Glu  Leu Glu Ala Leu Leu  Ser Ser Lys 
    1565                 1570                 1575             


Asp Asp  Val Gly Lys Ser Val  His Glu Leu Glu Arg  Ala Cys Arg 
    1580                 1585                 1590             


Val Ala  Glu Gln Ala Ala Asn  Asp Leu Arg Ala Gln  Val Thr Glu 
    1595                 1600                 1605             


Leu Glu  Asp Glu Leu Thr Ala  Ala Glu Asp Ala Lys  Leu Arg Leu 
    1610                 1615                 1620             


Glu Val  Thr Val Gln Ala Leu  Lys Thr Gln His Glu  Arg Asp Leu 
    1625                 1630                 1635             


Gln Gly  Arg Asp Glu Ala Gly  Glu Glu Arg Arg Arg  Gln Leu Ala 
    1640                 1645                 1650             


Lys Gln  Leu Arg Asp Ala Glu  Val Glu Arg Asp Glu  Glu Arg Lys 
    1655                 1660                 1665             


Gln Arg  Thr Leu Ala Val Ala  Ala Arg Lys Lys Leu  Glu Gly Glu 
    1670                 1675                 1680             


Leu Glu  Glu Leu Lys Ala Gln  Met Ala Ser Ala Gly  Gln Gly Lys 
    1685                 1690                 1695             


Glu Glu  Ala Val Lys Gln Leu  Arg Lys Met Gln Ala  Gln Met Lys 
    1700                 1705                 1710             


Glu Leu  Trp Arg Glu Val Glu  Glu Thr Arg Thr Ser  Arg Glu Glu 
    1715                 1720                 1725             


Ile Phe  Ser Gln Asn Arg Glu  Ser Glu Lys Arg Leu  Lys Gly Leu 
    1730                 1735                 1740             


Glu Ala  Glu Val Leu Arg Leu  Gln Glu Glu Leu Ala  Ala Ser Asp 
    1745                 1750                 1755             


Arg Ala  Arg Arg Gln Ala Gln  Gln Asp Arg Asp Glu  Met Ala Asp 
    1760                 1765                 1770             


Glu Val  Ala Asn Gly Asn Leu  Ser Lys Ala Ala Ile  Leu Glu Glu 
    1775                 1780                 1785             


Lys Arg  Gln Leu Glu Gly Arg  Leu Gly Gln Leu Glu  Glu Glu Leu 
    1790                 1795                 1800             


Glu Glu  Glu Gln Ser Asn Ser  Glu Leu Leu Asn Asp  Arg Tyr Arg 
    1805                 1810                 1815             


Lys Leu  Leu Leu Gln Val Glu  Ser Leu Thr Thr Glu  Leu Ser Ala 
    1820                 1825                 1830             


Glu Arg  Ser Phe Ser Ala Lys  Ala Glu Ser Gly Arg  Gln Gln Leu 
    1835                 1840                 1845             


Glu Arg  Gln Ile Gln Glu Leu  Arg Gly Arg Leu Gly  Glu Glu Asp 
    1850                 1855                 1860             


Ala Gly  Ala Arg Ala Arg His  Lys Met Thr Ile Ala  Ala Leu Glu 
    1865                 1870                 1875             


Ser Lys  Leu Ala Gln Ala Glu  Glu Gln Leu Glu Gln  Glu Thr Arg 
    1880                 1885                 1890             


Glu Arg  Ile Leu Ser Gly Lys  Leu Val Arg Arg Ala  Glu Lys Arg 
    1895                 1900                 1905             


Leu Lys  Glu Val Val Leu Gln  Val Glu Glu Glu Arg  Arg Val Ala 
    1910                 1915                 1920             


Asp Gln  Leu Arg Asp Gln Leu  Glu Lys Gly Asn Leu  Arg Val Lys 
    1925                 1930                 1935             


Gln Leu  Lys Arg Gln Leu Glu  Glu Ala Glu Glu Glu  Ala Ser Arg 
    1940                 1945                 1950             


Ala Gln  Ala Gly Arg Arg Arg  Leu Gln Arg Glu Leu  Glu Asp Val 
    1955                 1960                 1965             


Thr Glu  Ser Ala Glu Ser Met  Asn Arg Glu Val Thr  Thr Leu Arg 
    1970                 1975                 1980             


Asn Arg  Leu Arg Arg Gly Pro  Leu Thr Phe Thr Thr  Arg Thr Val 
    1985                 1990                 1995             


Arg Gln  Val Phe Arg Leu Glu  Glu Gly Val Ala Ser  Asp Glu Glu 
    2000                 2005                 2010             


Ala Glu  Glu Ala Gln Pro Gly  Ser Gly Pro Ser Pro  Glu Pro Glu 
    2015                 2020                 2025             


Gly Ser  Pro Pro Ala His Pro  Gln 
    2030                 2035     


<210>  27
<211>  1137
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Lys Cys Val Phe Val Thr Val Gly Thr Thr Ser Phe Asp Asp Leu 
1               5                   10                  15      


Ile Ala Cys Val Ser Ala Pro Asp Ser Leu Gln Lys Ile Glu Ser Leu 
            20                  25                  30          


Gly Tyr Asn Arg Leu Ile Leu Gln Ile Gly Arg Gly Thr Val Val Pro 
        35                  40                  45              


Glu Pro Phe Ser Thr Glu Ser Phe Thr Leu Asp Val Tyr Arg Tyr Lys 
    50                  55                  60                  


Asp Ser Leu Lys Glu Asp Ile Gln Lys Ala Asp Leu Val Ile Ser His 
65                  70                  75                  80  


Ala Gly Ala Gly Ser Cys Leu Glu Thr Leu Glu Lys Gly Lys Pro Leu 
                85                  90                  95      


Val Val Val Ile Asn Glu Lys Leu Met Asn Asn His Gln Leu Glu Leu 
            100                 105                 110         


Ala Lys Gln Leu His Lys Glu Gly His Leu Phe Tyr Cys Thr Cys Arg 
        115                 120                 125             


Val Leu Thr Cys Pro Gly Gln Ala Lys Ser Ile Ala Ser Ala Pro Gly 
    130                 135                 140                 


Lys Cys Gln Asp Ser Ala Ala Leu Thr Ser Thr Ala Phe Ser Gly Leu 
145                 150                 155                 160 


Asp Phe Gly Leu Leu Ser Gly Tyr Leu His Lys Gln Ala Leu Val Thr 
                165                 170                 175     


Ala Thr His Pro Thr Cys Thr Leu Leu Phe Pro Ser Cys His Ala Phe 
            180                 185                 190         


Phe Pro Leu Pro Leu Thr Pro Thr Leu Tyr Lys Met His Lys Gly Trp 
        195                 200                 205             


Lys Asn Tyr Cys Ser Gln Lys Ser Leu Asn Glu Ala Ser Met Asp Glu 
    210                 215                 220                 


Tyr Leu Gly Ser Leu Gly Leu Phe Arg Lys Leu Thr Ala Lys Asp Ala 
225                 230                 235                 240 


Ser Cys Leu Phe Arg Ala Ile Ser Glu Gln Leu Phe Cys Ser Gln Val 
                245                 250                 255     


His His Leu Glu Ile Arg Lys Ala Cys Val Ser Tyr Met Arg Glu Asn 
            260                 265                 270         


Gln Gln Thr Phe Glu Ser Tyr Val Glu Gly Ser Phe Glu Lys Tyr Leu 
        275                 280                 285             


Glu Arg Leu Gly Asp Pro Lys Glu Ser Ala Gly Gln Leu Glu Ile Arg 
    290                 295                 300                 


Ala Leu Ser Leu Ile Tyr Asn Arg Asp Phe Ile Leu Tyr Arg Phe Pro 
305                 310                 315                 320 


Gly Lys Pro Pro Thr Tyr Val Thr Asp Asn Gly Tyr Glu Asp Lys Ile 
                325                 330                 335     


Leu Leu Cys Tyr Ser Ser Ser Gly His Tyr Asp Ser Val Tyr Ser Lys 
            340                 345                 350         


Gln Phe Gln Ser Ser Ala Ala Val Cys Gln Ala Val Leu Tyr Glu Ile 
        355                 360                 365             


Leu Tyr Lys Asp Val Phe Val Val Asp Glu Glu Glu Leu Lys Thr Ala 
    370                 375                 380                 


Ile Lys Leu Phe Arg Ser Gly Ser Lys Lys Asn Arg Asn Asn Ala Val 
385                 390                 395                 400 


Thr Gly Ser Glu Asp Ala His Thr Asp Tyr Lys Ser Ser Asn Gln Asn 
                405                 410                 415     


Arg Met Glu Glu Trp Gly Ala Cys Tyr Asn Ala Glu Asn Ile Pro Glu 
            420                 425                 430         


Gly Tyr Asn Lys Gly Thr Glu Glu Thr Lys Ser Pro Glu Asn Pro Ser 
        435                 440                 445             


Lys Met Pro Phe Pro Tyr Lys Val Leu Lys Ala Leu Asp Pro Glu Ile 
    450                 455                 460                 


Tyr Arg Asn Val Glu Phe Asp Val Trp Leu Asp Ser Arg Lys Glu Leu 
465                 470                 475                 480 


Gln Lys Ser Asp Tyr Met Glu Tyr Ala Gly Arg Gln Tyr Tyr Leu Gly 
                485                 490                 495     


Asp Lys Cys Gln Val Cys Leu Glu Ser Glu Gly Arg Tyr Tyr Asn Ala 
            500                 505                 510         


His Ile Gln Glu Val Gly Asn Glu Asn Asn Ser Val Thr Val Phe Ile 
        515                 520                 525             


Glu Glu Leu Ala Glu Lys His Val Val Pro Leu Ala Asn Leu Lys Pro 
    530                 535                 540                 


Val Thr Gln Val Met Ser Val Pro Ala Trp Asn Ala Met Pro Ser Arg 
545                 550                 555                 560 


Lys Gly Arg Gly Tyr Gln Lys Met Pro Gly Gly Tyr Val Pro Glu Ile 
                565                 570                 575     


Val Ile Ser Glu Met Asp Ile Lys Gln Gln Lys Lys Met Phe Lys Lys 
            580                 585                 590         


Ile Arg Gly Lys Glu Val Tyr Met Thr Met Ala Tyr Gly Lys Gly Asp 
        595                 600                 605             


Pro Leu Leu Pro Pro Arg Leu Gln His Ser Met His Tyr Gly His Asp 
    610                 615                 620                 


Pro Pro Met His Tyr Ser Gln Thr Ala Gly Asn Val Met Ser Asn Glu 
625                 630                 635                 640 


His Phe His Pro Gln His Pro Ser Pro Arg Gln Gly Arg Gly Tyr Gly 
                645                 650                 655     


Met Pro Arg Asn Ser Ser Arg Phe Ile Asn Arg His Asn Met Pro Gly 
            660                 665                 670         


Pro Lys Val Asp Phe Tyr Pro Gly Pro Gly Lys Arg Cys Cys Gln Ser 
        675                 680                 685             


Tyr Asp Asn Phe Ser Tyr Arg Ser Arg Ser Phe Arg Arg Ser His Arg 
    690                 695                 700                 


Gln Met Ser Cys Val Asn Lys Glu Ser Gln Tyr Gly Phe Thr Pro Gly 
705                 710                 715                 720 


Asn Gly Gln Met Pro Arg Gly Leu Glu Glu Thr Ile Thr Phe Tyr Glu 
                725                 730                 735     


Val Glu Glu Gly Asp Glu Thr Ala Tyr Pro Thr Leu Pro Asn His Gly 
            740                 745                 750         


Gly Pro Ser Thr Met Val Pro Ala Thr Ser Gly Tyr Cys Val Gly Arg 
        755                 760                 765             


Arg Gly His Ser Ser Gly Lys Gln Thr Leu Asn Leu Glu Glu Gly Asn 
    770                 775                 780                 


Gly Gln Ser Glu Asn Gly Arg Tyr His Glu Glu Tyr Leu Tyr Arg Ala 
785                 790                 795                 800 


Glu Pro Asp Tyr Glu Thr Ser Gly Val Tyr Ser Thr Thr Ala Ser Thr 
                805                 810                 815     


Ala Asn Leu Ser Leu Gln Asp Arg Lys Ser Cys Ser Met Ser Pro Gln 
            820                 825                 830         


Asp Thr Val Thr Ser Tyr Asn Tyr Pro Gln Lys Met Met Gly Asn Ile 
        835                 840                 845             


Ala Ala Val Ala Ala Ser Cys Ala Asn Asn Val Pro Ala Pro Val Leu 
    850                 855                 860                 


Ser Asn Gly Ala Ala Ala Asn Gln Ala Ile Ser Thr Thr Ser Val Ser 
865                 870                 875                 880 


Ser Gln Asn Ala Ile Gln Pro Leu Phe Val Ser Pro Pro Thr His Gly 
                885                 890                 895     


Arg Pro Val Ile Ala Ser Pro Ser Tyr Pro Cys His Ser Ala Ile Pro 
            900                 905                 910         


His Ala Gly Ala Ser Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        915                 920                 925             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    930                 935                 940                 


Pro Ala Leu Asp Val Gly Glu Thr Ser Asn Leu Gln Pro Pro Pro Pro 
945                 950                 955                 960 


Leu Pro Pro Pro Pro Tyr Ser Cys Asp Pro Ser Gly Ser Asp Leu Pro 
                965                 970                 975     


Gln Asp Thr Lys Val Leu Gln Tyr Tyr Phe Asn Leu Gly Leu Gln Cys 
            980                 985                 990         


Tyr Tyr His Ser Tyr Trp His Ser  Met Val Tyr Val Pro  Gln Met Gln 
        995                 1000                 1005             


Gln Gln  Leu His Val Glu Asn  Tyr Pro Val Tyr Thr  Glu Pro Pro 
    1010                 1015                 1020             


Leu Val  Asp Gln Thr Val Pro  Gln Cys Tyr Ser Glu  Val Arg Arg 
    1025                 1030                 1035             


Glu Asp  Gly Ile Gln Ala Glu  Ala Ser Ala Asn Asp  Thr Phe Pro 
    1040                 1045                 1050             


Asn Ala  Asp Ser Ser Ser Val  Pro His Gly Ala Val  Tyr Tyr Pro 
    1055                 1060                 1065             


Val Met  Ser Asp Pro Tyr Gly  Gln Pro Pro Leu Pro  Gly Phe Asp 
    1070                 1075                 1080             


Ser Cys  Leu Pro Val Val Pro  Asp Tyr Ser Cys Val  Pro Pro Trp 
    1085                 1090                 1095             


His Pro  Val Gly Thr Ala Tyr  Gly Gly Ser Ser Gln  Ile His Gly 
    1100                 1105                 1110             


Ala Ile  Asn Pro Gly Pro Ile  Gly Cys Ile Ala Pro  Ser Pro Pro 
    1115                 1120                 1125             


Ala Ser  His Tyr Val Pro Gln  Gly Met 
    1130                 1135         


<210>  28
<211>  2541
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
1               5                   10                  15      


Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile 
            20                  25                  30          


Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 
        35                  40                  45              


Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
    50                  55                  60                  


Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
65                  70                  75                  80  


Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                85                  90                  95      


Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
            100                 105                 110         


Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
        115                 120                 125             


Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr 
    130                 135                 140                 


Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
145                 150                 155                 160 


Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                165                 170                 175     


Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
            180                 185                 190         


Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
        195                 200                 205             


Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
    210                 215                 220                 


Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
225                 230                 235                 240 


Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                245                 250                 255     


Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
            260                 265                 270         


Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
        275                 280                 285             


Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
    290                 295                 300                 


Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
305                 310                 315                 320 


Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                325                 330                 335     


Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn 
            340                 345                 350         


Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
        355                 360                 365             


Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
    370                 375                 380                 


Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
385                 390                 395                 400 


Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                405                 410                 415     


Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
            420                 425                 430         


Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
        435                 440                 445             


Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
    450                 455                 460                 


Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
465                 470                 475                 480 


His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                485                 490                 495     


Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
            500                 505                 510         


Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
        515                 520                 525             


Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
    530                 535                 540                 


Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
545                 550                 555                 560 


Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                565                 570                 575     


Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
            580                 585                 590         


Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
        595                 600                 605             


Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
    610                 615                 620                 


Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
625                 630                 635                 640 


Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                645                 650                 655     


Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 
            660                 665                 670         


Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
        675                 680                 685             


Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
    690                 695                 700                 


Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
705                 710                 715                 720 


Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                725                 730                 735     


Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
            740                 745                 750         


Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
        755                 760                 765             


Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
    770                 775                 780                 


Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
785                 790                 795                 800 


Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                805                 810                 815     


Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala 
            820                 825                 830         


Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
        835                 840                 845             


Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
    850                 855                 860                 


Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
865                 870                 875                 880 


Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                885                 890                 895     


Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
            900                 905                 910         


Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
        915                 920                 925             


Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 
    930                 935                 940                 


Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
945                 950                 955                 960 


Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                965                 970                 975     


Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
            980                 985                 990         


Phe Leu Gln Pro Gly Gly Lys Met  Val Ala Ala Ala Lys  Ala Ser Val 
        995                 1000                 1005             


Pro Thr  Ile Gln Asp Gln Ala  Ser Ala Met Gln Leu  Ser Gln Cys 
    1010                 1015                 1020             


Ala Lys  Asn Leu Gly Thr Ala  Leu Ala Glu Leu Arg  Thr Ala Ala 
    1025                 1030                 1035             


Gln Lys  Ala Gln Glu Ala Cys  Gly Pro Leu Glu Met  Asp Ser Ala 
    1040                 1045                 1050             


Leu Ser  Val Val Gln Asn Leu  Glu Lys Asp Leu Gln  Glu Val Lys 
    1055                 1060                 1065             


Ala Ala  Ala Arg Asp Gly Lys  Leu Lys Pro Leu Pro  Gly Glu Thr 
    1070                 1075                 1080             


Met Glu  Lys Cys Thr Gln Asp  Leu Gly Asn Ser Thr  Lys Ala Val 
    1085                 1090                 1095             


Ser Ser  Ala Ile Ala Gln Leu  Leu Gly Glu Val Ala  Gln Gly Asn 
    1100                 1105                 1110             


Glu Asn  Tyr Ala Gly Ile Ala  Ala Arg Asp Val Ala  Gly Gly Leu 
    1115                 1120                 1125             


Arg Ser  Leu Ala Gln Ala Ala  Arg Gly Val Ala Ala  Leu Thr Ser 
    1130                 1135                 1140             


Asp Pro  Ala Val Gln Ala Ile  Val Leu Asp Thr Ala  Ser Asp Val 
    1145                 1150                 1155             


Leu Asp  Lys Ala Ser Ser Leu  Ile Glu Glu Ala Lys  Lys Ala Ala 
    1160                 1165                 1170             


Gly His  Pro Gly Asp Pro Glu  Ser Gln Gln Arg Leu  Ala Gln Val 
    1175                 1180                 1185             


Ala Lys  Ala Val Thr Gln Ala  Leu Asn Arg Cys Val  Ser Cys Leu 
    1190                 1195                 1200             


Pro Gly  Gln Arg Asp Val Asp  Asn Ala Leu Arg Ala  Val Gly Asp 
    1205                 1210                 1215             


Ala Ser  Lys Arg Leu Leu Ser  Asp Ser Leu Pro Pro  Ser Thr Gly 
    1220                 1225                 1230             


Thr Phe  Gln Glu Ala Gln Ser  Arg Leu Asn Glu Ala  Ala Ala Gly 
    1235                 1240                 1245             


Leu Asn  Gln Ala Ala Thr Glu  Leu Val Gln Ala Ser  Arg Gly Thr 
    1250                 1255                 1260             


Pro Gln  Asp Leu Ala Arg Ala  Ser Gly Arg Phe Gly  Gln Asp Phe 
    1265                 1270                 1275             


Ser Thr  Phe Leu Glu Ala Gly  Val Glu Met Ala Gly  Gln Ala Pro 
    1280                 1285                 1290             


Ser Gln  Glu Asp Arg Ala Gln  Val Val Ser Asn Leu  Lys Gly Ile 
    1295                 1300                 1305             


Ser Met  Ser Ser Ser Lys Leu  Leu Leu Ala Ala Lys  Ala Leu Ser 
    1310                 1315                 1320             


Thr Asp  Pro Ala Ala Pro Asn  Leu Lys Ser Gln Leu  Ala Ala Ala 
    1325                 1330                 1335             


Ala Arg  Ala Val Thr Asp Ser  Ile Asn Gln Leu Ile  Thr Met Cys 
    1340                 1345                 1350             


Thr Gln  Gln Ala Pro Gly Gln  Lys Glu Cys Asp Asn  Ala Leu Arg 
    1355                 1360                 1365             


Glu Leu  Glu Thr Val Arg Glu  Leu Leu Glu Asn Pro  Val Gln Pro 
    1370                 1375                 1380             


Ile Asn  Asp Met Ser Tyr Phe  Gly Cys Leu Asp Ser  Val Met Glu 
    1385                 1390                 1395             


Asn Ser  Lys Val Leu Gly Glu  Ala Met Thr Gly Ile  Ser Gln Asn 
    1400                 1405                 1410             


Ala Lys  Asn Gly Asn Leu Pro  Glu Phe Gly Asp Ala  Ile Ser Thr 
    1415                 1420                 1425             


Ala Ser  Lys Ala Leu Cys Gly  Phe Thr Glu Ala Ala  Ala Gln Ala 
    1430                 1435                 1440             


Ala Tyr  Leu Val Gly Val Ser  Asp Pro Asn Ser Gln  Ala Gly Gln 
    1445                 1450                 1455             


Gln Gly  Leu Val Glu Pro Thr  Gln Phe Ala Arg Ala  Asn Gln Ala 
    1460                 1465                 1470             


Ile Gln  Met Ala Cys Gln Ser  Leu Gly Glu Pro Gly  Cys Thr Gln 
    1475                 1480                 1485             


Ala Gln  Val Leu Ser Ala Ala  Thr Ile Val Ala Lys  His Thr Ser 
    1490                 1495                 1500             


Ala Leu  Cys Asn Ser Cys Arg  Leu Ala Ser Ala Arg  Thr Thr Asn 
    1505                 1510                 1515             


Pro Thr  Ala Lys Arg Gln Phe  Val Gln Ser Ala Lys  Glu Val Ala 
    1520                 1525                 1530             


Asn Ser  Thr Ala Asn Leu Val  Lys Thr Ile Lys Ala  Leu Asp Gly 
    1535                 1540                 1545             


Ala Phe  Thr Glu Glu Asn Arg  Ala Gln Cys Arg Ala  Ala Thr Ala 
    1550                 1555                 1560             


Pro Leu  Leu Glu Ala Val Asp  Asn Leu Ser Ala Phe  Ala Ser Asn 
    1565                 1570                 1575             


Pro Glu  Phe Ser Ser Ile Pro  Ala Gln Ile Ser Pro  Glu Gly Arg 
    1580                 1585                 1590             


Ala Ala  Met Glu Pro Ile Val  Ile Ser Ala Lys Thr  Met Leu Glu 
    1595                 1600                 1605             


Ser Ala  Gly Gly Leu Ile Gln  Thr Ala Arg Ala Leu  Ala Val Asn 
    1610                 1615                 1620             


Pro Arg  Asp Pro Pro Ser Trp  Ser Val Leu Ala Gly  His Ser Arg 
    1625                 1630                 1635             


Thr Val  Ser Asp Ser Ile Lys  Lys Leu Ile Thr Ser  Met Arg Asp 
    1640                 1645                 1650             


Lys Ala  Pro Gly Gln Leu Glu  Cys Glu Thr Ala Ile  Ala Ala Leu 
    1655                 1660                 1665             


Asn Ser  Cys Leu Arg Asp Leu  Asp Gln Ala Ser Leu  Ala Ala Val 
    1670                 1675                 1680             


Ser Gln  Gln Leu Ala Pro Arg  Glu Gly Ile Ser Gln  Glu Ala Leu 
    1685                 1690                 1695             


His Thr  Gln Met Leu Thr Ala  Val Gln Glu Ile Ser  His Leu Ile 
    1700                 1705                 1710             


Glu Pro  Leu Ala Asn Ala Ala  Arg Ala Glu Ala Ser  Gln Leu Gly 
    1715                 1720                 1725             


His Lys  Val Ser Gln Met Ala  Gln Tyr Phe Glu Pro  Leu Thr Leu 
    1730                 1735                 1740             


Ala Ala  Val Gly Ala Ala Ser  Lys Thr Leu Ser His  Pro Gln Gln 
    1745                 1750                 1755             


Met Ala  Leu Leu Asp Gln Thr  Lys Thr Leu Ala Glu  Ser Ala Leu 
    1760                 1765                 1770             


Gln Leu  Leu Tyr Thr Ala Lys  Glu Ala Gly Gly Asn  Pro Lys Gln 
    1775                 1780                 1785             


Ala Ala  His Thr Gln Glu Ala  Leu Glu Glu Ala Val  Gln Met Met 
    1790                 1795                 1800             


Thr Glu  Ala Val Glu Asp Leu  Thr Thr Thr Leu Asn  Glu Ala Ala 
    1805                 1810                 1815             


Ser Ala  Ala Gly Val Val Gly  Gly Met Val Asp Ser  Ile Thr Gln 
    1820                 1825                 1830             


Ala Ile  Asn Gln Leu Asp Glu  Gly Pro Met Gly Glu  Pro Glu Gly 
    1835                 1840                 1845             


Ser Phe  Val Asp Tyr Gln Thr  Thr Met Val Arg Thr  Ala Lys Ala 
    1850                 1855                 1860             


Ile Ala  Val Thr Val Gln Glu  Met Val Thr Lys Ser  Asn Thr Ser 
    1865                 1870                 1875             


Pro Glu  Glu Leu Gly Pro Leu  Ala Asn Gln Leu Thr  Ser Asp Tyr 
    1880                 1885                 1890             


Gly Arg  Leu Ala Ser Glu Ala  Lys Pro Ala Ala Val  Ala Ala Glu 
    1895                 1900                 1905             


Asn Glu  Glu Ile Gly Ser His  Ile Lys His Arg Val  Gln Glu Leu 
    1910                 1915                 1920             


Gly His  Gly Cys Ala Ala Leu  Val Thr Lys Ala Gly  Ala Leu Gln 
    1925                 1930                 1935             


Cys Ser  Pro Ser Asp Ala Tyr  Thr Lys Lys Glu Leu  Ile Glu Cys 
    1940                 1945                 1950             


Ala Arg  Arg Val Ser Glu Lys  Val Ser His Val Leu  Ala Ala Leu 
    1955                 1960                 1965             


Gln Ala  Gly Asn Arg Gly Thr  Gln Ala Cys Ile Thr  Ala Ala Ser 
    1970                 1975                 1980             


Ala Val  Ser Gly Ile Ile Ala  Asp Leu Asp Thr Thr  Ile Met Phe 
    1985                 1990                 1995             


Ala Thr  Ala Gly Thr Leu Asn  Arg Glu Gly Thr Glu  Thr Phe Ala 
    2000                 2005                 2010             


Asp His  Arg Glu Gly Ile Leu  Lys Thr Ala Lys Val  Leu Val Glu 
    2015                 2020                 2025             


Asp Thr  Lys Val Leu Val Gln  Asn Ala Ala Gly Ser  Gln Glu Lys 
    2030                 2035                 2040             


Leu Ala  Gln Ala Ala Gln Ser  Ser Val Ala Thr Ile  Thr Arg Leu 
    2045                 2050                 2055             


Ala Asp  Val Val Lys Leu Gly  Ala Ala Ser Leu Gly  Ala Glu Asp 
    2060                 2065                 2070             


Pro Glu  Thr Gln Val Val Leu  Ile Asn Ala Val Lys  Asp Val Ala 
    2075                 2080                 2085             


Lys Ala  Leu Gly Asp Leu Ile  Ser Ala Thr Lys Ala  Ala Ala Gly 
    2090                 2095                 2100             


Lys Val  Gly Asp Asp Pro Ala  Val Trp Gln Leu Lys  Asn Ser Ala 
    2105                 2110                 2115             


Lys Val  Met Val Thr Asn Val  Thr Ser Leu Leu Lys  Thr Val Lys 
    2120                 2125                 2130             


Ala Val  Glu Asp Glu Ala Thr  Lys Gly Thr Arg Ala  Leu Glu Ala 
    2135                 2140                 2145             


Thr Thr  Glu His Ile Arg Gln  Glu Leu Ala Val Phe  Cys Ser Pro 
    2150                 2155                 2160             


Glu Pro  Pro Ala Lys Thr Ser  Thr Pro Glu Asp Phe  Ile Arg Met 
    2165                 2170                 2175             


Thr Lys  Gly Ile Thr Met Ala  Thr Ala Lys Ala Val  Ala Ala Gly 
    2180                 2185                 2190             


Asn Ser  Cys Arg Gln Glu Asp  Val Ile Ala Thr Ala  Asn Leu Ser 
    2195                 2200                 2205             


Arg Arg  Ala Ile Ala Asp Met  Leu Arg Ala Cys Lys  Glu Ala Ala 
    2210                 2215                 2220             


Tyr His  Pro Glu Val Ala Pro  Asp Val Arg Leu Arg  Ala Leu His 
    2225                 2230                 2235             


Tyr Gly  Arg Glu Cys Ala Asn  Gly Tyr Leu Glu Leu  Leu Asp His 
    2240                 2245                 2250             


Val Leu  Leu Thr Leu Gln Lys  Pro Ser Pro Glu Leu  Lys Gln Gln 
    2255                 2260                 2265             


Leu Thr  Gly His Ser Lys Arg  Val Ala Gly Ser Val  Thr Glu Leu 
    2270                 2275                 2280             


Ile Gln  Ala Ala Glu Ala Met  Lys Gly Thr Glu Trp  Val Asp Pro 
    2285                 2290                 2295             


Glu Asp  Pro Thr Val Ile Ala  Glu Asn Glu Leu Leu  Gly Ala Ala 
    2300                 2305                 2310             


Ala Ala  Ile Glu Ala Ala Ala  Lys Lys Leu Glu Gln  Leu Lys Pro 
    2315                 2320                 2325             


Arg Ala  Lys Pro Lys Glu Ala  Asp Glu Ser Leu Asn  Phe Glu Glu 
    2330                 2335                 2340             


Gln Ile  Leu Glu Ala Ala Lys  Ser Ile Ala Ala Ala  Thr Ser Ala 
    2345                 2350                 2355             


Leu Val  Lys Ala Ala Ser Ala  Ala Gln Arg Glu Leu  Val Ala Gln 
    2360                 2365                 2370             


Gly Lys  Val Gly Ala Ile Pro  Ala Asn Ala Leu Asp  Asp Gly Gln 
    2375                 2380                 2385             


Trp Ser  Gln Gly Leu Ile Ser  Ala Ala Arg Met Val  Ala Ala Ala 
    2390                 2395                 2400             


Thr Asn  Asn Leu Cys Glu Ala  Ala Asn Ala Ala Val  Gln Gly His 
    2405                 2410                 2415             


Ala Ser  Gln Glu Lys Leu Ile  Ser Ser Ala Lys Gln  Val Ala Ala 
    2420                 2425                 2430             


Ser Thr  Ala Gln Leu Leu Val  Ala Cys Lys Val Lys  Ala Asp Gln 
    2435                 2440                 2445             


Asp Ser  Glu Ala Met Lys Arg  Leu Gln Ala Ala Gly  Asn Ala Val 
    2450                 2455                 2460             


Lys Arg  Ala Ser Asp Asn Leu  Val Lys Ala Ala Gln  Lys Ala Ala 
    2465                 2470                 2475             


Ala Phe  Glu Glu Gln Glu Asn  Glu Thr Val Val Val  Lys Glu Lys 
    2480                 2485                 2490             


Met Val  Gly Gly Ile Ala Gln  Ile Ile Ala Ala Gln  Glu Glu Met 
    2495                 2500                 2505             


Leu Arg  Lys Glu Arg Glu Leu  Glu Glu Ala Arg Lys  Lys Leu Ala 
    2510                 2515                 2520             


Gln Ile  Arg Gln Gln Gln Tyr  Lys Phe Leu Pro Ser  Glu Leu Arg 
    2525                 2530                 2535             


Asp Glu  His 
    2540     


<210>  29
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Glu Leu Gly Glu Leu Lys His Met Val Met Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Ala Lys Ala Leu His Leu Leu Lys Ser Ser 
        35                  40                  45              


Cys Ala Pro Ser Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Arg Lys Thr Leu Gly Pro Ser Asp Leu Ser Leu Leu Ser Leu 
65                  70                  75                  80  


Pro Pro Gly Thr Ser Pro Val Gly Ser Pro Gly Pro Leu Ala Pro Ile 
                85                  90                  95      


Pro Pro Thr Leu Leu Ala Pro Gly Thr Leu Leu Gly Pro Lys Arg Glu 
            100                 105                 110         


Val Asp Met His Pro Pro Leu Pro Gln Pro Val His Pro Asp Val Thr 
        115                 120                 125             


Met Lys Pro Leu Pro Phe Tyr Glu Val Tyr Gly Glu Leu Ile Arg Pro 
    130                 135                 140                 


Thr Thr Leu Ala Ser Thr Ser Ser Gln Arg Phe Glu Glu Ala His Phe 
145                 150                 155                 160 


Thr Phe Ala Leu Thr Pro Gln Gln Val Gln Gln Ile Leu Thr Ser Arg 
                165                 170                 175     


Glu Val Leu Pro Gly Ala Lys Cys Asp Tyr Thr Ile Gln Val Gln Leu 
            180                 185                 190         


Arg Phe Cys Leu Cys Glu Thr Ser Cys Pro Gln Glu Asp Tyr Phe Pro 
        195                 200                 205             


Pro Asn Leu Phe Val Lys Val Asn Gly Lys Leu Cys Pro Leu Pro Gly 
    210                 215                 220                 


Tyr Leu Pro Pro Thr Lys Asn Gly Ala Glu Pro Lys Arg Pro Ser Arg 
225                 230                 235                 240 


Pro Ile Asn Ile Thr Pro Leu Ala Arg Leu Ser Ala Thr Val Pro Asn 
                245                 250                 255     


Thr Ile Val Val Asn Trp Ser Ser Glu Phe Gly Arg Asn Tyr Ser Leu 
            260                 265                 270         


Ser Val Tyr Leu Val Arg Gln Leu Thr Ala Gly Thr Leu Leu Gln Lys 
        275                 280                 285             


Leu Arg Ala Lys Gly Ile Arg Asn Pro Asp His Ser Arg Ala Leu Ile 
    290                 295                 300                 


Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Val Ala Thr Thr Ser 
305                 310                 315                 320 


Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg Leu Thr Val 
                325                 330                 335     


Pro Cys Arg Ala Leu Thr Cys Ala His Leu Gln Ser Phe Asp Ala Ala 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Thr Cys Pro Val 
        355                 360                 365             


Cys Asp Lys Lys Ala Pro Tyr Glu Ser Leu Ile Ile Asp Gly Leu Phe 
    370                 375                 380                 


Met Glu Ile Leu Ser Ser Cys Ser Asp Cys Asp Glu Ile Gln Phe Met 
385                 390                 395                 400 


Glu Asp Gly Ser Trp Cys Pro Met Lys Pro Lys Lys Glu Ala Ser Glu 
                405                 410                 415     


Val Cys Pro Pro Pro Gly Tyr Gly Leu Asp Gly Leu Gln Tyr Ser Pro 
            420                 425                 430         


Val Gln Gly Gly Asp Pro Ser Glu Asn Lys Lys Lys Val Glu Val Ile 
        435                 440                 445             


Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu Glu Asp Leu Pro Pro Thr 
    450                 455                 460                 


Lys Lys His Cys Ser Val Thr Ser Ala Ala Ile Pro Ala Leu Pro Gly 
465                 470                 475                 480 


Ser Lys Gly Val Leu Thr Ser Gly His Gln Pro Ser Ser Val Leu Arg 
                485                 490                 495     


Ser Pro Ala Met Gly Thr Leu Gly Gly Asp Phe Leu Ser Ser Leu Pro 
            500                 505                 510         


Leu His Glu Tyr Pro Pro Ala Phe Pro Leu Gly Ala Asp Ile Gln Gly 
        515                 520                 525             


Leu Asp Leu Phe Ser Phe Leu Gln Thr Glu Ser Gln His Tyr Gly Pro 
    530                 535                 540                 


Ser Val Ile Thr Ser Leu Asp Glu Gln Asp Ala Leu Gly His Phe Phe 
545                 550                 555                 560 


Gln Tyr Arg Gly Thr Pro Ser His Phe Leu Gly Pro Leu Ala Pro Thr 
                565                 570                 575     


Leu Gly Ser Ser His Cys Ser Ala Thr Pro Ala Pro Pro Pro Gly Arg 
            580                 585                 590         


Val Ser Ser Ile Val Ala Pro Gly Gly Ala Leu Arg Glu Gly His Gly 
        595                 600                 605             


Gly Pro Leu Pro Ser Gly Pro Ser Leu Thr Gly Cys Arg Ser Asp Ile 
    610                 615                 620                 


Ile Ser Leu Asp 
625             


<210>  30
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val 
        115                 120                 125             


Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu 
    130                 135                 140                 


Cys Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu 
    210                 215                 220                 


Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg 
    290                 295                 300                 


Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  31
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Pro Lys Lys Arg Pro Glu Thr Gln Lys Thr Ser Glu Ile Val 
1               5                   10                  15      


Leu Arg Pro Arg Asn Lys Arg Ser Arg Ser Pro Leu Glu Leu Glu Pro 
            20                  25                  30          


Glu Ala Lys Lys Leu Cys Ala Lys Gly Ser Gly Pro Ser Arg Arg Cys 
        35                  40                  45              


Asp Ser Asp Cys Leu Trp Val Gly Leu Ala Gly Pro Gln Ile Leu Pro 
    50                  55                  60                  


Pro Cys Arg Ser Ile Val Arg Thr Leu His Gln His Lys Leu Gly Arg 
65                  70                  75                  80  


Ala Ser Trp Pro Ser Val Gln Gln Gly Leu Gln Gln Ser Phe Leu His 
                85                  90                  95      


Thr Leu Asp Ser Tyr Arg Ile Leu Gln Lys Ala Ala Pro Phe Asp Arg 
            100                 105                 110         


Arg Ala Thr Ser Leu Ala Trp His Pro Thr His Pro Ser Thr Val Ala 
        115                 120                 125             


Val Gly Ser Lys Gly Gly Asp Ile Met Leu Trp Asn Phe Gly Ile Lys 
    130                 135                 140                 


Asp Lys Pro Thr Phe Ile Lys Gly Ile Gly Ala Gly Gly Ser Ile Thr 
145                 150                 155                 160 


Gly Leu Lys Phe Asn Pro Leu Asn Thr Asn Gln Phe Tyr Ala Ser Ser 
                165                 170                 175     


Met Glu Gly Thr Thr Arg Leu Gln Asp Phe Lys Gly Asn Ile Leu Arg 
            180                 185                 190         


Val Phe Ala Ser Ser Asp Thr Ile Asn Ile Trp Phe Cys Ser Leu Asp 
        195                 200                 205             


Val Ser Ala Ser Ser Arg Met Val Val Thr Gly Asp Asn Val Gly Asn 
    210                 215                 220                 


Val Ile Leu Leu Asn Met Asp Gly Lys Glu Leu Trp Asn Leu Arg Met 
225                 230                 235                 240 


His Lys Lys Lys Val Thr His Val Ala Leu Asn Pro Cys Cys Asp Trp 
                245                 250                 255     


Phe Leu Ala Thr Ala Ser Val Asp Gln Thr Val Lys Ile Trp Asp Leu 
            260                 265                 270         


Arg Gln Val Arg Gly Lys Ala Ser Phe Leu Tyr Ser Leu Pro His Arg 
        275                 280                 285             


His Pro Val Asn Ala Ala Cys Phe Ser Pro Asp Gly Ala Arg Leu Leu 
    290                 295                 300                 


Thr Thr Asp Gln Lys Ser Glu Ile Arg Val Tyr Ser Ala Ser Gln Trp 
305                 310                 315                 320 


Asp Cys Pro Leu Gly Leu Ile Pro His Pro His Arg His Phe Gln His 
                325                 330                 335     


Leu Thr Pro Ile Lys Ala Ala Trp His Pro Arg Tyr Asn Leu Ile Val 
            340                 345                 350         


Val Gly Arg Tyr Pro Asp Pro Asn Phe Lys Ser Cys Thr Pro Tyr Glu 
        355                 360                 365             


Leu Arg Thr Ile Asp Val Phe Asp Gly Asn Ser Gly Lys Met Met Cys 
    370                 375                 380                 


Gln Leu Tyr Asp Pro Glu Ser Ser Gly Ile Ser Ser Leu Asn Glu Phe 
385                 390                 395                 400 


Asn Pro Met Gly Asp Thr Leu Ala Ser Ala Met Gly Tyr His Ile Leu 
                405                 410                 415     


Ile Trp Ser Gln Glu Glu Ala Arg Thr Arg Lys 
            420                 425         


<210>  32
<211>  2288
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Gly Ser Pro Glu Glu Asn Lys Glu Met Arg Tyr Tyr Met Leu 
1               5                   10                  15      


Gln Arg Ser Ser Met Ser Gly Leu His Leu Val Lys Gln Gly Arg Asp 
            20                  25                  30          


Arg Lys Lys Ile Asp Ser Gln Arg Asp Phe Thr Val Ala Ser Pro Ala 
        35                  40                  45              


Glu Phe Val Thr Arg Phe Gly Gly Asn Lys Val Ile Glu Lys Val Leu 
    50                  55                  60                  


Ile Ala Asn Asn Gly Ile Ala Ala Val Lys Cys Met Arg Ser Ile Arg 
65                  70                  75                  80  


Arg Trp Ser Tyr Glu Met Phe Arg Asn Glu Arg Ala Ile Arg Phe Val 
                85                  90                  95      


Val Met Val Thr Pro Glu Asp Leu Lys Ala Asn Ala Glu Tyr Ile Lys 
            100                 105                 110         


Met Ala Asp His Tyr Val Pro Val Pro Gly Gly Pro Asn Asn Asn Asn 
        115                 120                 125             


Tyr Ala Asn Val Glu Leu Ile Leu Asp Ile Ala Lys Arg Ile Pro Val 
    130                 135                 140                 


Gln Ala Val Trp Ala Gly Trp Gly His Ala Ser Glu Asn Pro Lys Leu 
145                 150                 155                 160 


Pro Glu Leu Leu Leu Lys Asn Gly Ile Ala Phe Met Gly Pro Pro Ser 
                165                 170                 175     


Gln Ala Met Trp Ala Leu Gly Asp Lys Ile Ala Ser Ser Ile Val Ala 
            180                 185                 190         


Gln Thr Ala Gly Ile Pro Thr Leu Pro Trp Ser Gly Ser Gly Leu Arg 
        195                 200                 205             


Val Asp Trp Gln Glu Asn Asp Phe Ser Lys Arg Ile Leu Asn Val Pro 
    210                 215                 220                 


Gln Glu Leu Tyr Glu Lys Gly Tyr Val Lys Asp Val Asp Asp Gly Leu 
225                 230                 235                 240 


Gln Ala Ala Glu Glu Val Gly Tyr Pro Val Met Ile Lys Ala Ser Glu 
                245                 250                 255     


Gly Gly Gly Gly Lys Gly Ile Arg Lys Val Asn Asn Ala Asp Asp Phe 
            260                 265                 270         


Pro Asn Leu Phe Arg Gln Val Gln Ala Glu Val Pro Gly Ser Pro Ile 
        275                 280                 285             


Phe Val Met Arg Leu Ala Lys Gln Ser Arg His Leu Glu Val Gln Ile 
    290                 295                 300                 


Leu Ala Asp Gln Tyr Gly Asn Ala Ile Ser Leu Phe Gly Arg Asp Cys 
305                 310                 315                 320 


Ser Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Ala Thr 
                325                 330                 335     


Ile Ala Thr Pro Ala Val Phe Glu His Met Glu Gln Cys Ala Val Lys 
            340                 345                 350         


Leu Ala Lys Met Val Gly Tyr Val Ser Ala Gly Thr Val Glu Tyr Leu 
        355                 360                 365             


Tyr Ser Gln Asp Gly Ser Phe Tyr Phe Leu Glu Leu Asn Pro Arg Leu 
    370                 375                 380                 


Gln Val Glu His Pro Cys Thr Glu Met Val Ala Asp Val Asn Leu Pro 
385                 390                 395                 400 


Ala Ala Gln Leu Gln Ile Ala Met Gly Ile Pro Leu Tyr Arg Ile Lys 
                405                 410                 415     


Asp Ile Arg Met Met Tyr Gly Val Ser Pro Trp Gly Asp Ser Pro Ile 
            420                 425                 430         


Asp Phe Glu Asp Ser Ala His Val Pro Cys Pro Arg Gly His Val Ile 
        435                 440                 445             


Ala Ala Arg Ile Thr Ser Glu Asn Pro Asp Glu Gly Phe Lys Pro Ser 
    450                 455                 460                 


Ser Gly Thr Val Gln Glu Leu Asn Phe Arg Ser Asn Lys Asn Val Trp 
465                 470                 475                 480 


Gly Tyr Phe Ser Val Ala Ala Ala Gly Gly Leu His Glu Phe Ala Asp 
                485                 490                 495     


Ser Gln Phe Gly His Cys Phe Ser Trp Gly Glu Asn Arg Glu Glu Ala 
            500                 505                 510         


Ile Ser Asn Met Val Val Ala Leu Lys Glu Leu Ser Ile Arg Gly Asp 
        515                 520                 525             


Phe Arg Thr Thr Val Glu Tyr Leu Ile Lys Leu Leu Glu Thr Glu Ser 
    530                 535                 540                 


Phe Gln Met Asn Arg Ile Asp Thr Gly Trp Leu Asp Arg Leu Ile Ala 
545                 550                 555                 560 


Glu Lys Val Gln Ala Glu Arg Pro Asp Thr Met Leu Gly Val Val Cys 
                565                 570                 575     


Gly Ala Leu His Val Ala Asp Val Ser Leu Arg Asn Ser Val Ser Asn 
            580                 585                 590         


Phe Leu His Ser Leu Glu Arg Gly Gln Val Leu Pro Ala His Thr Leu 
        595                 600                 605             


Leu Asn Thr Val Asp Val Glu Leu Ile Tyr Glu Gly Val Lys Tyr Val 
    610                 615                 620                 


Leu Lys Val Thr Arg Gln Ser Pro Asn Ser Tyr Val Val Ile Met Asn 
625                 630                 635                 640 


Gly Ser Cys Val Glu Val Asp Val His Arg Leu Ser Asp Gly Gly Leu 
                645                 650                 655     


Leu Leu Ser Tyr Asp Gly Ser Ser Tyr Thr Thr Tyr Met Lys Glu Glu 
            660                 665                 670         


Val Asp Arg Tyr Arg Ile Thr Ile Gly Asn Lys Thr Cys Val Phe Glu 
        675                 680                 685             


Lys Glu Asn Asp Pro Ser Val Met Arg Ser Pro Ser Ala Gly Lys Leu 
    690                 695                 700                 


Ile Gln Tyr Ile Val Glu Asp Gly Gly His Val Phe Ala Gly Gln Cys 
705                 710                 715                 720 


Tyr Ala Glu Ile Glu Val Met Lys Met Val Met Thr Leu Thr Ala Val 
                725                 730                 735     


Glu Ser Gly Cys Ile His Tyr Val Lys Arg Pro Gly Ala Ala Leu Asp 
            740                 745                 750         


Pro Gly Cys Val Leu Ala Lys Met Gln Leu Asp Asn Pro Ser Lys Val 
        755                 760                 765             


Gln Gln Ala Glu Leu His Thr Gly Ser Leu Pro Arg Ile Gln Ser Thr 
    770                 775                 780                 


Ala Leu Arg Gly Glu Lys Leu His Arg Val Phe His Tyr Val Leu Asp 
785                 790                 795                 800 


Asn Leu Val Asn Val Met Asn Gly Tyr Cys Leu Pro Asp Pro Phe Phe 
                805                 810                 815     


Ser Ser Lys Val Lys Asp Trp Val Glu Arg Leu Met Lys Thr Leu Arg 
            820                 825                 830         


Asp Pro Ser Leu Pro Leu Leu Glu Leu Gln Asp Ile Met Thr Ser Val 
        835                 840                 845             


Ser Gly Arg Ile Pro Pro Asn Val Glu Lys Ser Ile Lys Lys Glu Met 
    850                 855                 860                 


Ala Gln Tyr Ala Ser Asn Ile Thr Ser Val Leu Cys Gln Phe Pro Ser 
865                 870                 875                 880 


Gln Gln Ile Ala Asn Ile Leu Asp Ser His Ala Ala Thr Leu Asn Arg 
                885                 890                 895     


Lys Ser Glu Arg Glu Val Phe Phe Met Asn Thr Gln Ser Ile Val Gln 
            900                 905                 910         


Leu Val Gln Arg Tyr Arg Ser Gly Ile Arg Gly His Met Lys Ala Val 
        915                 920                 925             


Val Met Asp Leu Leu Arg Gln Tyr Leu Arg Val Glu Thr Gln Phe Gln 
    930                 935                 940                 


Asn Gly His Tyr Asp Lys Cys Val Phe Ala Leu Arg Glu Glu Asn Lys 
945                 950                 955                 960 


Ser Asp Met Asn Thr Val Leu Asn Tyr Ile Phe Ser His Ala Gln Val 
                965                 970                 975     


Thr Lys Lys Asn Leu Leu Val Thr Met Leu Ile Asp Gln Leu Cys Gly 
            980                 985                 990         


Arg Asp Pro Thr Leu Thr Asp Glu  Leu Leu Asn Ile Leu  Thr Glu Leu 
        995                 1000                 1005             


Thr Gln  Leu Ser Lys Thr Thr  Asn Ala Lys Val Ala  Leu Arg Ala 
    1010                 1015                 1020             


Arg Gln  Val Leu Ile Ala Ser  His Leu Pro Ser Tyr  Glu Leu Arg 
    1025                 1030                 1035             


His Asn  Gln Val Glu Ser Ile  Phe Leu Ser Ala Ile  Asp Met Tyr 
    1040                 1045                 1050             


Gly His  Gln Phe Cys Ile Glu  Asn Leu Gln Lys Leu  Ile Leu Ser 
    1055                 1060                 1065             


Glu Thr  Ser Ile Phe Asp Val  Leu Pro Asn Phe Phe  Tyr His Ser 
    1070                 1075                 1080             


Asn Gln  Val Val Arg Met Ala  Ala Leu Glu Val Tyr  Val Arg Arg 
    1085                 1090                 1095             


Ala Tyr  Ile Ala Tyr Glu Leu  Asn Ser Val Gln His  Arg Gln Leu 
    1100                 1105                 1110             


Lys Asp  Asn Thr Cys Val Val  Glu Phe Gln Phe Met  Leu Pro Thr 
    1115                 1120                 1125             


Ser His  Pro Asn Arg Gly Asn  Ile Pro Thr Leu Asn  Arg Met Ser 
    1130                 1135                 1140             


Phe Ser  Ser Asn Leu Asn His  Tyr Gly Met Thr His  Val Ala Ser 
    1145                 1150                 1155             


Val Ser  Asp Val Leu Leu Asp  Asn Ser Phe Thr Pro  Pro Cys Gln 
    1160                 1165                 1170             


Arg Met  Gly Gly Met Val Ser  Phe Arg Thr Phe Glu  Asp Phe Val 
    1175                 1180                 1185             


Arg Ile  Phe Asp Glu Val Met  Gly Cys Phe Ser Asp  Ser Pro Pro 
    1190                 1195                 1200             


Gln Ser  Pro Thr Phe Pro Glu  Ala Gly His Thr Ser  Leu Tyr Asp 
    1205                 1210                 1215             


Glu Asp  Lys Val Pro Arg Asp  Glu Pro Ile His Ile  Leu Asn Val 
    1220                 1225                 1230             


Ala Ile  Lys Thr Asp Cys Asp  Ile Glu Asp Asp Arg  Leu Ala Ala 
    1235                 1240                 1245             


Met Phe  Arg Glu Phe Thr Gln  Gln Asn Lys Ala Thr  Leu Val Asp 
    1250                 1255                 1260             


His Gly  Ile Arg Arg Leu Thr  Phe Leu Val Ala Gln  Lys Asp Phe 
    1265                 1270                 1275             


Arg Lys  Gln Val Asn Tyr Glu  Val Asp Arg Arg Phe  His Arg Glu 
    1280                 1285                 1290             


Phe Pro  Lys Phe Phe Thr Phe  Arg Ala Arg Asp Lys  Phe Glu Glu 
    1295                 1300                 1305             


Asp Arg  Ile Tyr Arg His Leu  Glu Pro Ala Leu Ala  Phe Gln Leu 
    1310                 1315                 1320             


Glu Leu  Asn Arg Met Arg Asn  Phe Asp Leu Thr Ala  Ile Pro Cys 
    1325                 1330                 1335             


Ala Asn  His Lys Met His Leu  Tyr Leu Gly Ala Ala  Lys Val Glu 
    1340                 1345                 1350             


Val Gly  Thr Glu Val Thr Asp  Tyr Arg Phe Phe Val  Arg Ala Ile 
    1355                 1360                 1365             


Ile Arg  His Ser Asp Leu Val  Thr Lys Glu Ala Ser  Phe Glu Tyr 
    1370                 1375                 1380             


Leu Gln  Asn Glu Gly Glu Arg  Leu Leu Leu Glu Ala  Met Asp Glu 
    1385                 1390                 1395             


Leu Glu  Val Ala Phe Asn Asn  Thr Asn Val Arg Thr  Asp Cys Asn 
    1400                 1405                 1410             


His Ile  Phe Leu Asn Phe Val  Pro Thr Val Ile Met  Asp Pro Ser 
    1415                 1420                 1425             


Lys Ile  Glu Glu Ser Val Arg  Ser Met Val Met Arg  Tyr Gly Ser 
    1430                 1435                 1440             


Arg Leu  Trp Lys Leu Arg Val  Leu Gln Ala Glu Leu  Lys Ile Asn 
    1445                 1450                 1455             


Ile Arg  Leu Thr Pro Thr Gly  Lys Ala Ile Pro Ile  Arg Leu Phe 
    1460                 1465                 1470             


Leu Thr  Asn Glu Ser Gly Tyr  Tyr Leu Asp Ile Ser  Leu Tyr Lys 
    1475                 1480                 1485             


Glu Val  Thr Asp Ser Arg Thr  Ala Gln Ile Met Phe  Gln Ala Tyr 
    1490                 1495                 1500             


Gly Asp  Lys Gln Gly Pro Leu  His Gly Met Leu Ile  Asn Thr Pro 
    1505                 1510                 1515             


Tyr Val  Thr Lys Asp Leu Leu  Gln Ser Lys Arg Phe  Gln Ala Gln 
    1520                 1525                 1530             


Ser Leu  Gly Thr Thr Tyr Ile  Tyr Asp Ile Pro Glu  Met Phe Arg 
    1535                 1540                 1545             


Gln Ser  Leu Ile Lys Leu Trp  Glu Ser Met Ser Thr  Gln Ala Phe 
    1550                 1555                 1560             


Leu Pro  Ser Pro Pro Leu Pro  Ser Asp Met Leu Thr  Tyr Thr Glu 
    1565                 1570                 1575             


Leu Val  Leu Asp Asp Gln Gly  Gln Leu Val His Met  Asn Arg Leu 
    1580                 1585                 1590             


Pro Gly  Gly Asn Glu Ile Gly  Met Val Ala Trp Lys  Met Thr Phe 
    1595                 1600                 1605             


Lys Ser  Pro Glu Tyr Pro Glu  Gly Arg Asp Ile Ile  Val Ile Gly 
    1610                 1615                 1620             


Asn Asp  Ile Thr Tyr Arg Ile  Gly Ser Phe Gly Pro  Gln Glu Asp 
    1625                 1630                 1635             


Leu Leu  Phe Leu Arg Ala Ser  Glu Leu Ala Arg Ala  Glu Gly Ile 
    1640                 1645                 1650             


Pro Arg  Ile Tyr Val Ser Ala  Asn Ser Gly Ala Arg  Ile Gly Leu 
    1655                 1660                 1665             


Ala Glu  Glu Ile Arg His Met  Phe His Val Ala Trp  Val Asp Pro 
    1670                 1675                 1680             


Glu Asp  Pro Tyr Lys Gly Tyr  Arg Tyr Leu Tyr Leu  Thr Pro Gln 
    1685                 1690                 1695             


Asp Tyr  Lys Arg Val Ser Ala  Leu Asn Ser Val His  Cys Glu His 
    1700                 1705                 1710             


Val Glu  Asp Glu Gly Glu Ser  Arg Tyr Lys Ile Thr  Asp Ile Ile 
    1715                 1720                 1725             


Gly Lys  Glu Glu Gly Ile Gly  Pro Glu Asn Leu Arg  Gly Ser Gly 
    1730                 1735                 1740             


Met Ile  Ala Gly Glu Ser Ser  Leu Ala Tyr Asn Glu  Ile Ile Thr 
    1745                 1750                 1755             


Ile Ser  Leu Val Thr Cys Arg  Ala Ile Gly Ile Gly  Ala Tyr Leu 
    1760                 1765                 1770             


Val Arg  Leu Gly Gln Arg Thr  Ile Gln Val Glu Asn  Ser His Leu 
    1775                 1780                 1785             


Ile Leu  Thr Gly Ala Gly Ala  Leu Asn Lys Val Leu  Gly Arg Glu 
    1790                 1795                 1800             


Val Tyr  Thr Ser Asn Asn Gln  Leu Gly Gly Ile Gln  Ile Met His 
    1805                 1810                 1815             


Asn Asn  Gly Val Thr His Cys  Thr Val Cys Asp Asp  Phe Glu Gly 
    1820                 1825                 1830             


Val Phe  Thr Val Leu His Trp  Leu Ser Tyr Met Pro  Lys Ser Val 
    1835                 1840                 1845             


His Ser  Ser Val Pro Leu Leu  Asn Ser Lys Asp Pro  Ile Asp Arg 
    1850                 1855                 1860             


Ile Ile  Glu Phe Val Pro Thr  Lys Thr Pro Tyr Asp  Pro Arg Trp 
    1865                 1870                 1875             


Met Leu  Ala Gly Arg Pro His  Pro Thr Gln Lys Gly  Gln Trp Leu 
    1880                 1885                 1890             


Ser Gly  Phe Phe Asp Tyr Gly  Ser Phe Ser Glu Ile  Met Gln Pro 
    1895                 1900                 1905             


Trp Ala  Gln Thr Val Val Val  Gly Arg Ala Arg Leu  Gly Gly Ile 
    1910                 1915                 1920             


Pro Val  Gly Val Val Ala Val  Glu Thr Arg Thr Val  Glu Leu Ser 
    1925                 1930                 1935             


Ile Pro  Ala Asp Pro Ala Asn  Leu Asp Ser Glu Ala  Lys Ile Ile 
    1940                 1945                 1950             


Gln Gln  Ala Gly Gln Val Trp  Phe Pro Asp Ser Ala  Phe Lys Thr 
    1955                 1960                 1965             


Tyr Gln  Ala Ile Lys Asp Phe  Asn Arg Glu Gly Leu  Pro Leu Met 
    1970                 1975                 1980             


Val Phe  Ala Asn Trp Arg Gly  Phe Ser Gly Gly Met  Lys Asp Met 
    1985                 1990                 1995             


Tyr Asp  Gln Val Leu Lys Phe  Gly Ala Tyr Ile Val  Asp Gly Leu 
    2000                 2005                 2010             


Arg Glu  Cys Cys Gln Pro Val  Leu Val Tyr Ile Pro  Pro Gln Ala 
    2015                 2020                 2025             


Glu Leu  Arg Gly Gly Ser Trp  Val Val Ile Asp Ser  Ser Ile Asn 
    2030                 2035                 2040             


Pro Arg  His Met Glu Met Tyr  Ala Asp Arg Glu Ser  Arg Gly Ser 
    2045                 2050                 2055             


Val Leu  Glu Pro Glu Gly Thr  Val Glu Ile Lys Phe  Arg Arg Lys 
    2060                 2065                 2070             


Asp Leu  Val Lys Thr Met Arg  Arg Val Asp Pro Val  Tyr Ile His 
    2075                 2080                 2085             


Leu Ala  Glu Arg Leu Gly Thr  Pro Glu Leu Ser Thr  Ala Glu Arg 
    2090                 2095                 2100             


Lys Glu  Leu Glu Asn Lys Leu  Lys Glu Arg Glu Glu  Phe Leu Ile 
    2105                 2110                 2115             


Pro Ile  Tyr His Gln Val Ala  Val Gln Phe Ala Asp  Leu His Asp 
    2120                 2125                 2130             


Thr Pro  Gly Arg Met Gln Glu  Lys Gly Val Ile Ser  Asp Ile Leu 
    2135                 2140                 2145             


Asp Trp  Lys Thr Ser Arg Thr  Phe Phe Tyr Trp Arg  Leu Arg Arg 
    2150                 2155                 2160             


Leu Leu  Leu Glu Asp Leu Val  Lys Lys Lys Ile His  Asn Ala Asn 
    2165                 2170                 2175             


Pro Glu  Leu Thr Asp Gly Gln  Ile Gln Ala Met Leu  Arg Arg Trp 
    2180                 2185                 2190             


Phe Val  Glu Val Glu Gly Thr  Val Lys Ala Tyr Val  Trp Asp Asn 
    2195                 2200                 2205             


Asn Lys  Asp Leu Ala Glu Trp  Leu Glu Lys Gln Leu  Thr Glu Glu 
    2210                 2215                 2220             


Asp Gly  Val His Ser Val Ile  Glu Glu Asn Ile Lys  Cys Ile Ser 
    2225                 2230                 2235             


Arg Asp  Tyr Val Leu Lys Gln  Ile Arg Ser Leu Val  Gln Ala Asn 
    2240                 2245                 2250             


Pro Glu  Val Ala Met Asp Ser  Ile Ile His Met Thr  Gln His Ile 
    2255                 2260                 2265             


Ser Pro  Thr Gln Arg Ala Glu  Val Ile Arg Ile Leu  Ser Thr Met 
    2270                 2275                 2280             


Asp Ser  Pro Ser Thr 
    2285             


<210>  33
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  33

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln 
                85                  90                  95      


Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu 
            100                 105                 110         


Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg 
        115                 120                 125             


Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys 
    130                 135                 140                 


Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr 
145                 150                 155                 160 


Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp 
                165                 170                 175     


Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu 
            180                 185                 190         


Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp 
        195                 200                 205             


Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Glu Ser Ser Val Ser Ser 
    210                 215                 220                 


Ser Ser Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly 
225                 230                 235                 240 


Ser Val Thr Glu Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala 
                245                 250                 255     


Glu Gln Met Val Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met 
            260                 265                 270         


Asn Leu Leu Ser Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu 
        275                 280                 285             


Gly Leu Pro Ala Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys 
    290                 295                 300                 


Glu Lys Gln Lys Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu 
305                 310                 315                 320 


Pro Gly Gln Tyr Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His 
                325                 330                 335     


Val Thr Leu Glu Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu 
            340                 345                 350         


Gln His Leu Leu Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val 
        355                 360                 365             


Ala Gly Gly Val Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu 
    370                 375                 380                 


Arg Ile Ser Pro Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg 
385                 390                 395                 400 


Pro Leu Asn Arg Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala 
                405                 410                 415     


Gln Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys 
            420                 425                 430         


Gln Tyr Gln Gln Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile 
        435                 440                 445             


Glu Gln Leu Lys Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu 
    450                 455                 460                 


Leu Gln Gly Asp Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly 
465                 470                 475                 480 


Asn Ser Thr Arg Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly 
                485                 490                 495     


Gln Val Gly Ala Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu 
            500                 505                 510         


Asp Ala Gln Ile Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met 
        515                 520                 525             


Gln Gln Val Ile Gly Lys Asp Leu Ala Pro Gly Phe Val Ile Lys Val 
    530                 535                 540                 


Ile Ile 
545     


<210>  34
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Phe Arg Ile Tyr Lys Arg Lys Val Leu Ile Leu Thr Leu Val 
1               5                   10                  15      


Val Ala Ala Cys Gly Phe Val Leu Trp Ser Ser Asn Gly Arg Gln Arg 
            20                  25                  30          


Lys Asn Glu Ala Leu Ala Pro Pro Leu Leu Asp Ala Glu Pro Ala Arg 
        35                  40                  45              


Gly Ala Gly Gly Arg Gly Gly Asp His Pro Ser Val Ala Val Gly Ile 
    50                  55                  60                  


Arg Arg Val Ser Asn Val Ser Ala Ala Ser Leu Val Pro Ala Val Pro 
65                  70                  75                  80  


Gln Pro Glu Ala Asp Asn Leu Thr Leu Arg Tyr Arg Ser Leu Val Tyr 
                85                  90                  95      


Gln Leu Asn Phe Asp Gln Thr Leu Arg Asn Val Asp Lys Ala Gly Thr 
            100                 105                 110         


Trp Ala Pro Arg Glu Leu Val Leu Val Val Gln Val His Asn Arg Pro 
        115                 120                 125             


Glu Tyr Leu Arg Leu Leu Leu Asp Ser Leu Arg Lys Ala Gln Gly Ile 
    130                 135                 140                 


Asp Asn Val Leu Val Ile Phe Ser His Asp Phe Trp Ser Thr Glu Ile 
145                 150                 155                 160 


Asn Gln Leu Ile Ala Gly Val Asn Phe Cys Pro Val Leu Gln Val Phe 
                165                 170                 175     


Phe Pro Phe Ser Ile Gln Leu Tyr Pro Asn Glu Phe Pro Gly Ser Asp 
            180                 185                 190         


Pro Arg Asp Cys Pro Arg Asp Leu Pro Lys Asn Ala Ala Leu Lys Leu 
        195                 200                 205             


Gly Cys Ile Asn Ala Glu Tyr Pro Asp Ser Phe Gly His Tyr Arg Glu 
    210                 215                 220                 


Ala Lys Phe Ser Gln Thr Lys His His Trp Trp Trp Lys Leu His Phe 
225                 230                 235                 240 


Val Trp Glu Arg Val Lys Ile Leu Arg Asp Tyr Ala Gly Leu Ile Leu 
                245                 250                 255     


Phe Leu Glu Glu Asp His Tyr Leu Ala Pro Asp Phe Tyr His Val Phe 
            260                 265                 270         


Lys Lys Met Trp Lys Leu Lys Gln Gln Glu Cys Pro Glu Cys Asp Val 
        275                 280                 285             


Leu Ser Leu Gly Thr Tyr Ser Ala Ser Arg Ser Phe Tyr Gly Met Ala 
    290                 295                 300                 


Asp Lys Val Asp Val Lys Thr Trp Lys Ser Thr Glu His Asn Met Gly 
305                 310                 315                 320 


Leu Ala Leu Thr Arg Asn Ala Tyr Gln Lys Leu Ile Glu Cys Thr Asp 
                325                 330                 335     


Thr Phe Cys Thr Tyr Asp Asp Tyr Asn Trp Asp Trp Thr Leu Gln Tyr 
            340                 345                 350         


Leu Thr Val Ser Cys Leu Pro Lys Phe Trp Lys Val Leu Val Pro Gln 
        355                 360                 365             


Ile Pro Arg Ile Phe His Ala Gly Asp Cys Gly Met His His Lys Lys 
    370                 375                 380                 


Thr Cys Arg Pro Ser Thr Gln Ser Ala Gln Ile Glu Ser Leu Leu Asn 
385                 390                 395                 400 


Asn Asn Lys Gln Tyr Met Phe Pro Glu Thr Leu Thr Ile Ser Glu Lys 
                405                 410                 415     


Phe Thr Val Val Ala Ile Ser Pro Pro Arg Lys Asn Gly Gly Trp Gly 
            420                 425                 430         


Asp Ile Arg Asp His Glu Leu Cys Lys Ser Tyr Arg Arg Leu Gln 
        435                 440                 445         


<210>  35
<211>  1975
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Gly Glu Gln Met Asp Pro Thr Gly Ser Gln Leu Asp Ser Asp 
1               5                   10                  15      


Phe Ser Gln Gln Asp Thr Pro Cys Leu Ile Ile Glu Asp Ser Gln Pro 
            20                  25                  30          


Glu Ser Gln Val Leu Glu Asp Asp Ser Gly Ser His Phe Ser Met Leu 
        35                  40                  45              


Ser Arg His Leu Pro Asn Leu Gln Thr His Lys Glu Asn Pro Val Leu 
    50                  55                  60                  


Asp Val Val Ser Asn Pro Glu Gln Thr Ala Gly Glu Glu Arg Gly Asp 
65                  70                  75                  80  


Gly Asn Ser Gly Phe Asn Glu His Leu Lys Glu Asn Lys Val Ala Asp 
                85                  90                  95      


Pro Val Asp Ser Ser Asn Leu Asp Thr Cys Gly Ser Ile Ser Gln Val 
            100                 105                 110         


Ile Glu Gln Leu Pro Gln Pro Asn Arg Thr Ser Ser Val Leu Gly Met 
        115                 120                 125             


Ser Val Glu Ser Ala Pro Ala Val Glu Glu Glu Lys Gly Glu Glu Leu 
    130                 135                 140                 


Glu Gln Lys Glu Lys Glu Lys Glu Glu Asp Thr Ser Gly Asn Thr Thr 
145                 150                 155                 160 


His Ser Leu Gly Ala Glu Asp Thr Ala Ser Ser Gln Leu Gly Phe Gly 
                165                 170                 175     


Val Leu Glu Leu Ser Gln Ser Gln Asp Val Glu Glu Asn Thr Val Pro 
            180                 185                 190         


Tyr Glu Val Asp Lys Glu Gln Leu Gln Ser Val Thr Thr Asn Ser Gly 
        195                 200                 205             


Tyr Thr Arg Leu Ser Asp Val Asp Ala Asn Thr Ala Ile Lys His Glu 
    210                 215                 220                 


Glu Gln Ser Asn Glu Asp Ile Pro Ile Ala Glu Gln Ser Ser Lys Asp 
225                 230                 235                 240 


Ile Pro Val Thr Ala Gln Pro Ser Lys Asp Val His Val Val Lys Glu 
                245                 250                 255     


Gln Asn Pro Pro Pro Ala Arg Ser Glu Asp Met Pro Phe Ser Pro Lys 
            260                 265                 270         


Ala Ser Val Ala Ala Met Glu Ala Lys Glu Gln Leu Ser Ala Gln Glu 
        275                 280                 285             


Leu Met Glu Ser Gly Leu Gln Ile Gln Lys Ser Pro Glu Pro Glu Val 
    290                 295                 300                 


Leu Ser Thr Gln Glu Asp Leu Phe Asp Gln Ser Asn Lys Thr Val Ser 
305                 310                 315                 320 


Ser Asp Gly Cys Ser Thr Pro Ser Arg Glu Glu Gly Gly Cys Ser Leu 
                325                 330                 335     


Ala Ser Thr Pro Ala Thr Thr Leu His Leu Leu Gln Leu Ser Gly Gln 
            340                 345                 350         


Arg Ser Leu Val Gln Asp Ser Leu Ser Thr Asn Ser Ser Asp Leu Val 
        355                 360                 365             


Ala Pro Ser Pro Asp Ala Phe Arg Ser Thr Pro Phe Ile Val Pro Ser 
    370                 375                 380                 


Ser Pro Thr Glu Gln Glu Gly Arg Gln Asp Lys Pro Met Asp Thr Ser 
385                 390                 395                 400 


Val Leu Ser Glu Glu Gly Gly Glu Pro Phe Gln Lys Lys Leu Gln Ser 
                405                 410                 415     


Gly Glu Pro Val Glu Leu Glu Asn Pro Pro Leu Leu Pro Glu Ser Thr 
            420                 425                 430         


Val Ser Pro Gln Ala Ser Thr Pro Ile Ser Gln Ser Thr Pro Val Phe 
        435                 440                 445             


Pro Pro Gly Ser Leu Pro Ile Pro Ser Gln Pro Gln Phe Ser His Asp 
    450                 455                 460                 


Ile Phe Ile Pro Ser Pro Ser Leu Glu Glu Gln Ser Asn Asp Gly Lys 
465                 470                 475                 480 


Lys Asp Gly Asp Met His Ser Ser Ser Leu Thr Val Glu Cys Ser Lys 
                485                 490                 495     


Thr Ser Glu Ile Glu Pro Lys Asn Ser Pro Glu Asp Leu Gly Leu Ser 
            500                 505                 510         


Leu Thr Gly Asp Ser Cys Lys Leu Met Leu Ser Thr Ser Glu Tyr Ser 
        515                 520                 525             


Gln Ser Pro Lys Met Glu Ser Leu Ser Ser His Arg Ile Asp Glu Asp 
    530                 535                 540                 


Gly Glu Asn Thr Gln Ile Glu Asp Thr Glu Pro Met Ser Pro Val Leu 
545                 550                 555                 560 


Asn Ser Lys Phe Val Pro Ala Glu Asn Asp Ser Ile Leu Met Asn Pro 
                565                 570                 575     


Ala Gln Asp Gly Glu Val Gln Leu Ser Gln Asn Asp Asp Lys Thr Lys 
            580                 585                 590         


Gly Asp Asp Thr Asp Thr Arg Asp Asp Ile Ser Ile Leu Ala Thr Gly 
        595                 600                 605             


Cys Lys Gly Arg Glu Glu Thr Val Ala Glu Asp Val Cys Ile Asp Leu 
    610                 615                 620                 


Thr Cys Asp Ser Gly Ser Gln Ala Val Pro Ser Pro Ala Thr Arg Ser 
625                 630                 635                 640 


Glu Ala Leu Ser Ser Val Leu Asp Gln Glu Glu Ala Met Glu Ile Lys 
                645                 650                 655     


Glu His His Pro Glu Glu Gly Ser Ser Gly Ser Glu Val Glu Glu Ile 
            660                 665                 670         


Pro Glu Thr Pro Cys Glu Ser Gln Gly Glu Glu Leu Lys Glu Glu Asn 
        675                 680                 685             


Met Glu Ser Val Pro Leu His Leu Ser Leu Thr Glu Thr Gln Ser Gln 
    690                 695                 700                 


Gly Leu Cys Leu Gln Lys Glu Met Pro Lys Lys Glu Cys Ser Glu Ala 
705                 710                 715                 720 


Met Glu Val Glu Thr Ser Val Ile Ser Ile Asp Ser Pro Gln Lys Leu 
                725                 730                 735     


Ala Ile Leu Asp Gln Glu Leu Glu His Lys Glu Gln Glu Ala Trp Glu 
            740                 745                 750         


Glu Ala Thr Ser Glu Asp Ser Ser Val Val Ile Val Asp Val Lys Glu 
        755                 760                 765             


Pro Ser Pro Arg Val Asp Val Ser Cys Glu Pro Leu Glu Gly Val Glu 
    770                 775                 780                 


Lys Cys Ser Asp Ser Gln Ser Trp Glu Asp Ile Ala Pro Glu Ile Glu 
785                 790                 795                 800 


Pro Cys Ala Glu Asn Arg Leu Asp Thr Lys Glu Glu Lys Ser Val Glu 
                805                 810                 815     


Tyr Glu Gly Asp Leu Lys Ser Gly Thr Ala Glu Thr Glu Pro Val Glu 
            820                 825                 830         


Gln Asp Ser Ser Gln Pro Ser Leu Pro Leu Val Arg Ala Asp Asp Pro 
        835                 840                 845             


Leu Arg Leu Asp Gln Glu Leu Gln Gln Pro Gln Thr Gln Glu Lys Thr 
    850                 855                 860                 


Ser Asn Ser Leu Thr Glu Asp Ser Lys Met Ala Asn Ala Lys Gln Leu 
865                 870                 875                 880 


Ser Ser Asp Ala Glu Ala Gln Lys Leu Gly Lys Pro Ser Ala His Ala 
                885                 890                 895     


Ser Gln Ser Phe Cys Glu Ser Ser Ser Glu Thr Pro Phe His Phe Thr 
            900                 905                 910         


Leu Pro Lys Glu Gly Asp Ile Ile Pro Pro Leu Thr Gly Ala Thr Pro 
        915                 920                 925             


Pro Leu Ile Gly His Leu Lys Leu Glu Pro Lys Arg His Ser Thr Pro 
    930                 935                 940                 


Ile Gly Ile Ser Asn Tyr Pro Glu Ser Thr Ile Ala Thr Ser Asp Val 
945                 950                 955                 960 


Met Ser Glu Ser Met Val Glu Thr His Asp Pro Ile Leu Gly Ser Gly 
                965                 970                 975     


Lys Gly Asp Ser Gly Ala Ala Pro Asp Val Asp Asp Lys Leu Cys Leu 
            980                 985                 990         


Arg Met Lys Leu Val Ser Pro Glu  Thr Glu Ala Ser Glu  Glu Ser Leu 
        995                 1000                 1005             


Gln Phe  Asn Leu Glu Lys Pro  Ala Thr Gly Glu Arg  Lys Asn Gly 
    1010                 1015                 1020             


Ser Thr  Ala Val Ala Glu Ser  Val Ala Ser Pro Gln  Lys Thr Met 
    1025                 1030                 1035             


Ser Val  Leu Ser Cys Ile Cys  Glu Ala Arg Gln Glu  Asn Glu Ala 
    1040                 1045                 1050             


Arg Ser  Glu Asp Pro Pro Thr  Thr Pro Ile Arg Gly  Asn Leu Leu 
    1055                 1060                 1065             


His Phe  Pro Ser Ser Gln Gly  Glu Glu Glu Lys Glu  Lys Leu Glu 
    1070                 1075                 1080             


Gly Asp  His Thr Ile Arg Gln  Ser Gln Gln Pro Met  Lys Pro Ile 
    1085                 1090                 1095             


Ser Pro  Val Lys Asp Pro Val  Ser Pro Ala Ser Gln  Lys Met Val 
    1100                 1105                 1110             


Ile Gln  Gly Pro Ser Ser Pro  Gln Gly Glu Ala Met  Val Thr Asp 
    1115                 1120                 1125             


Val Leu  Glu Asp Gln Lys Glu  Gly Arg Ser Thr Asn  Lys Glu Asn 
    1130                 1135                 1140             


Pro Ser  Lys Ala Leu Ile Glu  Arg Pro Ser Gln Asn  Asn Ile Gly 
    1145                 1150                 1155             


Ile Gln  Thr Met Glu Cys Ser  Leu Arg Val Pro Glu  Thr Val Ser 
    1160                 1165                 1170             


Ala Ala  Thr Gln Thr Ile Lys  Asn Val Cys Glu Gln  Gly Thr Ser 
    1175                 1180                 1185             


Thr Val  Asp Gln Asn Phe Gly  Lys Gln Asp Ala Thr  Val Gln Thr 
    1190                 1195                 1200             


Glu Arg  Gly Ser Gly Glu Lys  Pro Val Ser Ala Pro  Gly Asp Asp 
    1205                 1210                 1215             


Thr Glu  Ser Leu His Ser Gln  Gly Glu Glu Glu Phe  Asp Met Pro 
    1220                 1225                 1230             


Gln Pro  Pro His Gly His Val  Leu His Arg His Met  Arg Thr Ile 
    1235                 1240                 1245             


Arg Glu  Val Arg Thr Leu Val  Thr Arg Val Ile Thr  Asp Val Tyr 
    1250                 1255                 1260             


Tyr Val  Asp Gly Thr Glu Val  Glu Arg Lys Val Thr  Glu Glu Thr 
    1265                 1270                 1275             


Glu Glu  Pro Ile Val Glu Cys  Gln Glu Cys Glu Thr  Glu Val Ser 
    1280                 1285                 1290             


Pro Ser  Gln Thr Gly Gly Ser  Ser Gly Asp Leu Gly  Asp Ile Ser 
    1295                 1300                 1305             


Ser Phe  Ser Ser Lys Ala Ser  Ser Leu His Arg Thr  Ser Ser Gly 
    1310                 1315                 1320             


Thr Ser  Leu Ser Ala Met His  Ser Ser Gly Ser Ser  Gly Lys Gly 
    1325                 1330                 1335             


Ala Gly  Pro Leu Arg Gly Lys  Thr Ser Gly Thr Glu  Pro Ala Asp 
    1340                 1345                 1350             


Phe Ala  Leu Pro Ser Ser Arg  Gly Gly Pro Gly Lys  Leu Ser Pro 
    1355                 1360                 1365             


Arg Lys  Gly Val Ser Gln Thr  Gly Thr Pro Val Cys  Glu Glu Asp 
    1370                 1375                 1380             


Gly Asp  Ala Gly Leu Gly Ile  Arg Gln Gly Gly Lys  Ala Pro Val 
    1385                 1390                 1395             


Thr Pro  Arg Gly Arg Gly Arg  Arg Gly Arg Pro Pro  Ser Arg Thr 
    1400                 1405                 1410             


Thr Gly  Thr Arg Glu Thr Ala  Val Pro Gly Pro Leu  Gly Ile Glu 
    1415                 1420                 1425             


Asp Ile  Ser Pro Asn Leu Ser  Pro Asp Asp Lys Ser  Phe Ser Arg 
    1430                 1435                 1440             


Val Val  Pro Arg Val Pro Asp  Ser Thr Arg Arg Thr  Asp Val Gly 
    1445                 1450                 1455             


Ala Gly  Ala Leu Arg Arg Ser  Asp Ser Pro Glu Ile  Pro Phe Gln 
    1460                 1465                 1470             


Ala Ala  Ala Gly Pro Ser Asp  Gly Leu Asp Ala Ser  Ser Pro Gly 
    1475                 1480                 1485             


Asn Ser  Phe Val Gly Leu Arg  Val Val Ala Lys Trp  Ser Ser Asn 
    1490                 1495                 1500             


Gly Tyr  Phe Tyr Ser Gly Lys  Ile Thr Arg Asp Val  Gly Ala Gly 
    1505                 1510                 1515             


Lys Tyr  Lys Leu Leu Phe Asp  Asp Gly Tyr Glu Cys  Asp Val Leu 
    1520                 1525                 1530             


Gly Lys  Asp Ile Leu Leu Cys  Asp Pro Ile Pro Leu  Asp Thr Glu 
    1535                 1540                 1545             


Val Thr  Ala Leu Ser Glu Asp  Glu Tyr Phe Ser Ala  Gly Val Val 
    1550                 1555                 1560             


Lys Gly  His Arg Lys Glu Ser  Gly Glu Leu Tyr Tyr  Ser Ile Glu 
    1565                 1570                 1575             


Lys Glu  Gly Gln Arg Lys Trp  Tyr Lys Arg Met Ala  Val Ile Leu 
    1580                 1585                 1590             


Ser Leu  Glu Gln Gly Asn Arg  Leu Arg Glu Gln Tyr  Gly Leu Gly 
    1595                 1600                 1605             


Pro Tyr  Glu Ala Val Thr Pro  Leu Thr Lys Ala Ala  Asp Ile Ser 
    1610                 1615                 1620             


Leu Asp  Asn Leu Val Glu Gly  Lys Arg Lys Arg Arg  Ser Asn Val 
    1625                 1630                 1635             


Ser Ser  Pro Ala Thr Pro Thr  Ala Ser Ser Ser Ser  Ser Thr Thr 
    1640                 1645                 1650             


Pro Thr  Arg Lys Ile Thr Glu  Ser Pro Arg Ala Ser  Met Gly Val 
    1655                 1660                 1665             


Leu Ser  Gly Lys Arg Lys Leu  Ile Thr Ser Glu Glu  Glu Arg Ser 
    1670                 1675                 1680             


Pro Ala  Lys Arg Gly Arg Lys  Ser Ala Thr Val Lys  Pro Val Gly 
    1685                 1690                 1695             


Ala Gly  Glu Phe Val Ser Pro  Cys Glu Ser Gly Asp  Asn Thr Gly 
    1700                 1705                 1710             


Glu Pro  Ser Ala Leu Glu Glu  Gln Arg Gly Pro Leu  Pro Leu Asn 
    1715                 1720                 1725             


Lys Thr  Leu Phe Leu Gly Tyr  Ala Phe Leu Leu Thr  Met Ala Thr 
    1730                 1735                 1740             


Thr Ser  Asp Lys Leu Ala Ser  Arg Ser Lys Leu Pro  Asp Gly Pro 
    1745                 1750                 1755             


Thr Gly  Ser Ser Glu Glu Glu  Glu Glu Phe Leu Glu  Ile Pro Pro 
    1760                 1765                 1770             


Phe Asn  Lys Gln Tyr Thr Glu  Ser Gln Leu Arg Ala  Gly Ala Gly 
    1775                 1780                 1785             


Tyr Ile  Leu Glu Asp Phe Asn  Glu Ala Gln Cys Asn  Thr Ala Tyr 
    1790                 1795                 1800             


Gln Cys  Leu Leu Ile Ala Asp  Gln His Cys Arg Thr  Arg Lys Tyr 
    1805                 1810                 1815             


Phe Leu  Cys Leu Ala Ser Gly  Ile Pro Cys Val Ser  His Val Trp 
    1820                 1825                 1830             


Val His  Asp Ser Cys His Ala  Asn Gln Leu Gln Asn  Tyr Arg Asn 
    1835                 1840                 1845             


Tyr Leu  Leu Pro Ala Gly Tyr  Ser Leu Glu Glu Gln  Arg Ile Leu 
    1850                 1855                 1860             


Asp Trp  Gln Pro Arg Glu Asn  Pro Phe Gln Asn Leu  Lys Val Leu 
    1865                 1870                 1875             


Leu Val  Ser Asp Gln Gln Gln  Asn Phe Leu Glu Leu  Trp Ser Glu 
    1880                 1885                 1890             


Ile Leu  Met Thr Gly Gly Ala  Ala Ser Val Lys Gln  His His Ser 
    1895                 1900                 1905             


Ser Ala  His Asn Lys Asp Ile  Ala Leu Gly Val Phe  Asp Val Val 
    1910                 1915                 1920             


Val Thr  Asp Pro Ser Cys Pro  Ala Ser Val Leu Lys  Cys Ala Glu 
    1925                 1930                 1935             


Ala Leu  Gln Leu Pro Val Val  Ser Gln Glu Trp Val  Ile Gln Cys 
    1940                 1945                 1950             


Leu Ile  Val Gly Glu Arg Ile  Gly Phe Lys Gln His  Pro Lys Tyr 
    1955                 1960                 1965             


Lys His  Asp Tyr Val Ser His  
    1970                 1975 


<210>  36
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Arg Tyr Arg Leu Ala Trp Leu Leu His Pro Ala Leu Pro Ser Thr 
1               5                   10                  15      


Phe Arg Ser Val Leu Gly Ala Arg Leu Pro Pro Pro Glu Arg Leu Cys 
            20                  25                  30          


Gly Phe Gln Lys Lys Thr Tyr Ser Lys Met Asn Asn Pro Ala Ile Lys 
        35                  40                  45              


Arg Ile Gly Asn His Ile Thr Lys Ser Pro Glu Asp Lys Arg Glu Tyr 
    50                  55                  60                  


Arg Gly Leu Glu Leu Ala Asn Gly Ile Lys Val Leu Leu Ile Ser Asp 
65                  70                  75                  80  


Pro Thr Thr Asp Lys Ser Ser Ala Ala Leu Asp Val His Ile Gly Ser 
                85                  90                  95      


Leu Ser Asp Pro Pro Asn Ile Ala Gly Leu Ser His Phe Cys Glu His 
            100                 105                 110         


Met Leu Phe Leu Gly Thr Lys Lys Tyr Pro Lys Glu Asn Glu Tyr Ser 
        115                 120                 125             


Gln Phe Leu Ser Glu His Ala Gly Ser Ser Asn Ala Phe Thr Ser Gly 
    130                 135                 140                 


Glu His Thr Asn Tyr Tyr Phe Asp Val Ser His Glu His Leu Glu Gly 
145                 150                 155                 160 


Ala Leu Asp Arg Phe Ala Gln Phe Phe Leu Cys Pro Leu Phe Asp Glu 
                165                 170                 175     


Ser Cys Lys Asp Arg Glu Val Asn Ala Val Asp Ser Glu His Glu Lys 
            180                 185                 190         


Asn Val Met Asn Asp Ala Trp Arg Leu Phe Gln Leu Glu Lys Ala Thr 
        195                 200                 205             


Gly Asn Pro Lys His Pro Phe Ser Lys Phe Gly Thr Gly Asn Lys Tyr 
    210                 215                 220                 


Thr Leu Glu Thr Arg Pro Asn Gln Glu Gly Ile Asp Val Arg Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Phe His Ser Ala Tyr Tyr Ser Ser Asn Leu Met Ala Val 
                245                 250                 255     


Cys Val Leu Gly Arg Glu Ser Leu Asp Asp Leu Thr Asn Leu Val Val 
            260                 265                 270         


Lys Leu Phe Ser Glu Val Glu Asn Lys Asn Val Pro Leu Pro Glu Phe 
        275                 280                 285             


Pro Glu His Pro Phe Gln Glu Glu His Leu Lys Gln Leu Tyr Lys Ile 
    290                 295                 300                 


Val Pro Ile Lys Asp Ile Arg Asn Leu Tyr Val Thr Phe Pro Ile Pro 
305                 310                 315                 320 


Asp Leu Gln Lys Tyr Tyr Lys Ser Asn Pro Gly His Tyr Leu Gly His 
                325                 330                 335     


Leu Ile Gly His Glu Gly Pro Gly Ser Leu Leu Ser Glu Leu Lys Ser 
            340                 345                 350         


Lys Gly Trp Val Asn Thr Leu Val Gly Gly Gln Lys Glu Gly Ala Arg 
        355                 360                 365             


Gly Phe Met Phe Phe Ile Ile Asn Val Asp Leu Thr Glu Glu Gly Leu 
    370                 375                 380                 


Leu His Val Glu Asp Ile Ile Leu His Met Phe Gln Tyr Ile Gln Lys 
385                 390                 395                 400 


Leu Arg Ala Glu Gly Pro Gln Glu Trp Val Phe Gln Glu Cys Lys Asp 
                405                 410                 415     


Leu Asn Ala Val Ala Phe Arg Phe Lys Asp Lys Glu Arg Pro Arg Gly 
            420                 425                 430         


Tyr Thr Ser Lys Ile Ala Gly Ile Leu His Tyr Tyr Pro Leu Glu Glu 
        435                 440                 445             


Val Leu Thr Ala Glu Tyr Leu Leu Glu Glu Phe Arg Pro Asp Leu Ile 
    450                 455                 460                 


Glu Met Val Leu Asp Lys Leu Arg Pro Glu Asn Val Arg Val Ala Ile 
465                 470                 475                 480 


Val Ser Lys Ser Phe Glu Gly Lys Thr Asp Arg Thr Glu Glu Trp Tyr 
                485                 490                 495     


Gly Thr Gln Tyr Lys Gln Glu Ala Ile Pro Asp Glu Val Ile Lys Lys 
            500                 505                 510         


Trp Gln Asn Ala Asp Leu Asn Gly Lys Phe Lys Leu Pro Thr Lys Asn 
        515                 520                 525             


Glu Phe Ile Pro Thr Asn Phe Glu Ile Leu Pro Leu Glu Lys Glu Ala 
    530                 535                 540                 


Thr Pro Tyr Pro Ala Leu Ile Lys Asp Thr Ala Met Ser Lys Leu Trp 
545                 550                 555                 560 


Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys Ala Cys Leu Asn Phe 
                565                 570                 575     


Glu Phe Phe Ser Pro Phe Ala Tyr Val Asp Pro Leu His Cys Asn Met 
            580                 585                 590         


Ala Tyr Leu Tyr Leu Glu Leu Leu Lys Asp Ser Leu Asn Glu Tyr Ala 
        595                 600                 605             


Tyr Ala Ala Glu Leu Ala Gly Leu Ser Tyr Asp Leu Gln Asn Thr Ile 
    610                 615                 620                 


Tyr Gly Met Tyr Leu Ser Val Lys Gly Tyr Asn Asp Lys Gln Pro Ile 
625                 630                 635                 640 


Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr Phe Glu Ile Asp Glu 
                645                 650                 655     


Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met Arg Ser Leu Asn Asn 
            660                 665                 670         


Phe Arg Ala Glu Gln Pro His Gln His Ala Met Tyr Tyr Leu Arg Leu 
        675                 680                 685             


Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu Leu Lys Glu Ala Leu 
    690                 695                 700                 


Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe Ile Pro Gln Leu Leu 
705                 710                 715                 720 


Ser Arg Leu His Ile Glu Ala Leu Leu His Gly Asn Ile Thr Lys Gln 
                725                 730                 735     


Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp Thr Leu Ile Glu His 
            740                 745                 750         


Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu Val Arg Tyr Arg Glu 
        755                 760                 765             


Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr Gln Gln Arg Asn Glu 
    770                 775                 780                 


Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr Gln Thr Asp Met Gln 
785                 790                 795                 800 


Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe Cys Gln Ile Ile Ser 
                805                 810                 815     


Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu Gln Leu Gly Tyr Ile 
            820                 825                 830         


Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile Gln Gly Leu Arg Phe 
        835                 840                 845             


Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu Glu Ser Arg Val Glu 
    850                 855                 860                 


Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu Asp Met Thr Glu Glu 
865                 870                 875                 880 


Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile Arg Arg Leu Asp Lys 
                885                 890                 895     


Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr Trp Gly Glu Ile Ile 
            900                 905                 910         


Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr Glu Val Ala Tyr Leu 
        915                 920                 925             


Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe Tyr Lys Glu Met Leu 
    930                 935                 940                 


Ala Val Asp Ala Pro Arg Arg His Lys Val Ser Val His Val Leu Ala 
945                 950                 955                 960 


Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu Phe Pro Cys Gln Asn 
                965                 970                 975     


Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro Gln Pro Glu Val Ile 
            980                 985                 990         


Gln Asn Met Thr Glu Phe Lys Arg  Gly Leu Pro Leu Phe  Pro Leu Val 
        995                 1000                 1005             


Lys Pro  His Ile Asn Phe Met  Ala Ala Lys Leu 
    1010                 1015                 


<210>  37
<211>  2458
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ser Gly Ser Thr Gln Pro Val Ala Gln Thr Trp Arg Ala Thr Glu 
1               5                   10                  15      


Pro Arg Tyr Pro Pro His Ser Leu Ser Tyr Pro Val Gln Ile Ala Arg 
            20                  25                  30          


Thr His Thr Asp Val Gly Leu Leu Glu Tyr Gln His His Ser Arg Asp 
        35                  40                  45              


Tyr Ala Ser His Leu Ser Pro Gly Ser Ile Ile Gln Pro Gln Arg Arg 
    50                  55                  60                  


Arg Pro Ser Leu Leu Ser Glu Phe Gln Pro Gly Asn Glu Arg Ser Gln 
65                  70                  75                  80  


Glu Leu His Leu Arg Pro Glu Ser His Ser Tyr Leu Pro Glu Leu Gly 
                85                  90                  95      


Lys Ser Glu Met Glu Phe Ile Glu Ser Lys Arg Pro Arg Leu Glu Leu 
            100                 105                 110         


Leu Pro Asp Pro Leu Leu Arg Pro Ser Pro Leu Leu Ala Thr Gly Gln 
        115                 120                 125             


Pro Ala Gly Ser Glu Asp Leu Thr Lys Asp Arg Ser Leu Thr Gly Lys 
    130                 135                 140                 


Leu Glu Pro Val Ser Pro Pro Ser Pro Pro His Thr Asp Pro Glu Leu 
145                 150                 155                 160 


Glu Leu Val Pro Pro Arg Leu Ser Lys Glu Glu Leu Ile Gln Asn Met 
                165                 170                 175     


Asp Arg Val Asp Arg Glu Ile Thr Met Val Glu Gln Gln Ile Ser Lys 
            180                 185                 190         


Leu Lys Lys Lys Gln Gln Gln Leu Glu Glu Glu Ala Ala Lys Pro Pro 
        195                 200                 205             


Glu Pro Glu Lys Pro Val Ser Pro Pro Pro Ile Glu Ser Lys His Arg 
    210                 215                 220                 


Ser Leu Val Gln Ile Ile Tyr Asp Glu Asn Arg Lys Lys Ala Glu Ala 
225                 230                 235                 240 


Ala His Arg Ile Leu Glu Gly Leu Gly Pro Gln Val Glu Leu Pro Leu 
                245                 250                 255     


Tyr Asn Gln Pro Ser Asp Thr Arg Gln Tyr His Glu Asn Ile Lys Ile 
            260                 265                 270         


Asn Gln Ala Met Arg Lys Lys Leu Ile Leu Tyr Phe Lys Arg Arg Asn 
        275                 280                 285             


His Ala Arg Lys Gln Trp Glu Gln Lys Phe Cys Gln Arg Tyr Asp Gln 
    290                 295                 300                 


Leu Met Glu Ala Trp Glu Lys Lys Val Glu Arg Ile Glu Asn Asn Pro 
305                 310                 315                 320 


Arg Arg Arg Ala Lys Glu Ser Lys Val Arg Glu Tyr Tyr Glu Lys Gln 
                325                 330                 335     


Phe Pro Glu Ile Arg Lys Gln Arg Glu Leu Gln Glu Arg Met Gln Arg 
            340                 345                 350         


Val Gly Gln Arg Gly Ser Gly Leu Ser Met Ser Ala Ala Arg Ser Glu 
        355                 360                 365             


His Glu Val Ser Glu Ile Ile Asp Gly Leu Ser Glu Gln Glu Asn Leu 
    370                 375                 380                 


Glu Lys Gln Met Arg Gln Leu Ala Val Ile Pro Pro Met Leu Tyr Asp 
385                 390                 395                 400 


Ala Asp Gln Gln Arg Ile Lys Phe Ile Asn Met Asn Gly Leu Met Ala 
                405                 410                 415     


Asp Pro Met Lys Val Tyr Lys Asp Arg Gln Val Met Asn Met Trp Ser 
            420                 425                 430         


Glu Gln Glu Lys Glu Thr Phe Arg Glu Lys Phe Met Gln His Pro Lys 
        435                 440                 445             


Asn Phe Gly Leu Ile Ala Ser Phe Leu Glu Arg Lys Thr Val Ala Glu 
    450                 455                 460                 


Cys Val Leu Tyr Tyr Tyr Leu Thr Lys Lys Asn Glu Asn Tyr Lys Ser 
465                 470                 475                 480 


Leu Val Arg Arg Ser Tyr Arg Arg Arg Gly Lys Ser Gln Gln Gln Gln 
                485                 490                 495     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Met Pro 
            500                 505                 510         


Arg Ser Ser Gln Glu Glu Lys Asp Glu Lys Glu Lys Glu Lys Glu Ala 
        515                 520                 525             


Glu Lys Glu Glu Glu Lys Pro Glu Val Glu Asn Asp Lys Glu Asp Leu 
    530                 535                 540                 


Leu Lys Glu Lys Thr Asp Asp Thr Ser Gly Glu Asp Asn Asp Glu Lys 
545                 550                 555                 560 


Glu Ala Val Ala Ser Lys Gly Arg Lys Thr Ala Asn Ser Gln Gly Arg 
                565                 570                 575     


Arg Lys Gly Arg Ile Thr Arg Ser Met Ala Asn Glu Ala Asn Ser Glu 
            580                 585                 590         


Glu Ala Ile Thr Pro Gln Gln Ser Ala Glu Leu Ala Ser Met Glu Leu 
        595                 600                 605             


Asn Glu Ser Ser Arg Trp Thr Glu Glu Glu Met Glu Thr Ala Lys Lys 
    610                 615                 620                 


Gly Leu Leu Glu His Gly Arg Asn Trp Ser Ala Ile Ala Arg Met Val 
625                 630                 635                 640 


Gly Ser Lys Thr Val Ser Gln Cys Lys Asn Phe Tyr Phe Asn Tyr Lys 
                645                 650                 655     


Lys Arg Gln Asn Leu Asp Glu Ile Leu Gln Gln His Lys Leu Lys Met 
            660                 665                 670         


Glu Lys Glu Arg Asn Ala Arg Arg Lys Lys Lys Lys Ala Pro Ala Ala 
        675                 680                 685             


Ala Ser Glu Glu Ala Ala Phe Pro Pro Val Val Glu Asp Glu Glu Met 
    690                 695                 700                 


Glu Ala Ser Gly Val Ser Gly Asn Glu Glu Glu Met Val Glu Glu Ala 
705                 710                 715                 720 


Glu Ala Thr Val Asn Asn Ser Ser Asp Thr Glu Ser Ile Pro Ser Pro 
                725                 730                 735     


His Thr Glu Ala Ala Lys Asp Thr Gly Gln Asn Gly Pro Lys Pro Pro 
            740                 745                 750         


Ala Thr Leu Gly Ala Asp Gly Pro Pro Pro Gly Pro Pro Thr Pro Pro 
        755                 760                 765             


Pro Glu Asp Ile Pro Ala Pro Thr Glu Pro Thr Pro Ala Ser Glu Ala 
    770                 775                 780                 


Thr Gly Ala Pro Thr Pro Pro Pro Ala Pro Pro Ser Pro Ser Ala Pro 
785                 790                 795                 800 


Pro Pro Val Val Pro Lys Glu Glu Lys Glu Glu Glu Thr Ala Ala Ala 
                805                 810                 815     


Pro Pro Val Glu Glu Gly Glu Glu Gln Lys Pro Pro Ala Ala Glu Glu 
            820                 825                 830         


Leu Ala Val Asp Thr Gly Lys Ala Glu Glu Pro Val Lys Ser Glu Cys 
        835                 840                 845             


Thr Glu Glu Ala Glu Glu Gly Pro Ala Lys Gly Lys Asp Ala Glu Ala 
    850                 855                 860                 


Ala Glu Ala Thr Ala Glu Gly Ala Leu Lys Ala Glu Lys Lys Glu Gly 
865                 870                 875                 880 


Gly Ser Gly Arg Ala Thr Thr Ala Lys Ser Ser Gly Ala Pro Gln Asp 
                885                 890                 895     


Ser Asp Ser Ser Ala Thr Cys Ser Ala Asp Glu Val Asp Glu Ala Glu 
            900                 905                 910         


Gly Gly Asp Lys Asn Arg Leu Leu Ser Pro Arg Pro Ser Leu Leu Thr 
        915                 920                 925             


Pro Thr Gly Asp Pro Arg Ala Asn Ala Ser Pro Gln Lys Pro Leu Asp 
    930                 935                 940                 


Leu Lys Gln Leu Lys Gln Arg Ala Ala Ala Ile Pro Pro Ile Gln Val 
945                 950                 955                 960 


Thr Lys Val His Glu Pro Pro Arg Glu Asp Ala Ala Pro Thr Lys Pro 
                965                 970                 975     


Ala Pro Pro Ala Pro Pro Pro Pro Gln Asn Leu Gln Pro Glu Ser Asp 
            980                 985                 990         


Ala Pro Gln Gln Pro Gly Ser Ser  Pro Arg Gly Lys Ser  Arg Ser Pro 
        995                 1000                 1005             


Ala Pro  Pro Ala Asp Lys Glu  Ala Glu Lys Pro Val  Phe Phe Pro 
    1010                 1015                 1020             


Ala Phe  Ala Ala Glu Ala Gln  Lys Leu Pro Gly Asp  Pro Pro Cys 
    1025                 1030                 1035             


Trp Thr  Ser Gly Leu Pro Phe  Pro Val Pro Pro Arg  Glu Val Ile 
    1040                 1045                 1050             


Lys Ala  Ser Pro His Ala Pro  Asp Pro Ser Ala Phe  Ser Tyr Ala 
    1055                 1060                 1065             


Pro Pro  Gly His Pro Leu Pro  Leu Gly Leu His Asp  Thr Ala Arg 
    1070                 1075                 1080             


Pro Val  Leu Pro Arg Pro Pro  Thr Ile Ser Asn Pro  Pro Pro Leu 
    1085                 1090                 1095             


Ile Ser  Ser Ala Lys His Pro  Ser Val Leu Glu Arg  Gln Ile Gly 
    1100                 1105                 1110             


Ala Ile  Ser Gln Gly Met Ser  Val Gln Leu His Val  Pro Tyr Ser 
    1115                 1120                 1125             


Glu His  Ala Lys Ala Pro Val  Gly Pro Val Thr Met  Gly Leu Pro 
    1130                 1135                 1140             


Leu Pro  Met Asp Pro Lys Lys  Leu Ala Pro Phe Ser  Gly Val Lys 
    1145                 1150                 1155             


Gln Glu  Gln Leu Ser Pro Arg  Gly Gln Ala Gly Pro  Pro Glu Ser 
    1160                 1165                 1170             


Leu Gly  Val Pro Thr Ala Gln  Glu Ala Ser Val Leu  Arg Gly Thr 
    1175                 1180                 1185             


Ala Leu  Gly Ser Val Pro Gly  Gly Ser Ile Thr Lys  Gly Ile Pro 
    1190                 1195                 1200             


Ser Thr  Arg Val Pro Ser Asp  Ser Ala Ile Thr Tyr  Arg Gly Ser 
    1205                 1210                 1215             


Ile Thr  His Gly Thr Pro Ala  Asp Val Leu Tyr Lys  Gly Thr Ile 
    1220                 1225                 1230             


Thr Arg  Ile Ile Gly Glu Asp  Ser Pro Ser Arg Leu  Asp Arg Gly 
    1235                 1240                 1245             


Arg Glu  Asp Ser Leu Pro Lys  Gly His Val Ile Tyr  Glu Gly Lys 
    1250                 1255                 1260             


Lys Gly  His Val Leu Ser Tyr  Glu Gly Gly Met Ser  Val Thr Gln 
    1265                 1270                 1275             


Cys Ser  Lys Glu Asp Gly Arg  Ser Ser Ser Gly Pro  Pro His Glu 
    1280                 1285                 1290             


Thr Ala  Ala Pro Lys Arg Thr  Tyr Asp Met Met Glu  Gly Arg Val 
    1295                 1300                 1305             


Gly Arg  Ala Ile Ser Ser Ala  Ser Ile Glu Gly Leu  Met Gly Arg 
    1310                 1315                 1320             


Ala Ile  Pro Pro Glu Arg His  Ser Pro His His Leu  Lys Glu Gln 
    1325                 1330                 1335             


His His  Ile Arg Gly Ser Ile  Thr Gln Gly Ile Pro  Arg Ser Tyr 
    1340                 1345                 1350             


Val Glu  Ala Gln Glu Asp Tyr  Leu Arg Arg Glu Ala  Lys Leu Leu 
    1355                 1360                 1365             


Lys Arg  Glu Gly Thr Pro Pro  Pro Pro Pro Pro Ser  Arg Asp Leu 
    1370                 1375                 1380             


Thr Glu  Ala Tyr Lys Thr Gln  Ala Leu Gly Pro Leu  Lys Leu Lys 
    1385                 1390                 1395             


Pro Ala  His Glu Gly Leu Val  Ala Thr Val Lys Glu  Ala Gly Arg 
    1400                 1405                 1410             


Ser Ile  His Glu Ile Pro Arg  Glu Glu Leu Arg His  Thr Pro Glu 
    1415                 1420                 1425             


Leu Pro  Leu Ala Pro Arg Pro  Leu Lys Glu Gly Ser  Ile Thr Gln 
    1430                 1435                 1440             


Gly Thr  Pro Leu Lys Tyr Asp  Thr Gly Ala Ser Thr  Thr Gly Ser 
    1445                 1450                 1455             


Lys Lys  His Asp Val Arg Ser  Leu Ile Gly Ser Pro  Gly Arg Thr 
    1460                 1465                 1470             


Phe Pro  Pro Val His Pro Leu  Asp Val Met Ala Asp  Ala Arg Ala 
    1475                 1480                 1485             


Leu Glu  Arg Ala Cys Tyr Glu  Glu Ser Leu Lys Ser  Arg Pro Gly 
    1490                 1495                 1500             


Thr Ala  Ser Ser Ser Gly Gly  Ser Ile Ala Arg Gly  Ala Pro Val 
    1505                 1510                 1515             


Ile Val  Pro Glu Leu Gly Lys  Pro Arg Gln Ser Pro  Leu Thr Tyr 
    1520                 1525                 1530             


Glu Asp  His Gly Ala Pro Phe  Ala Gly His Leu Pro  Arg Gly Ser 
    1535                 1540                 1545             


Pro Val  Thr Thr Arg Glu Pro  Thr Pro Arg Leu Gln  Glu Gly Ser 
    1550                 1555                 1560             


Leu Ser  Ser Ser Lys Ala Ser  Gln Asp Arg Lys Leu  Thr Ser Thr 
    1565                 1570                 1575             


Pro Arg  Glu Ile Ala Lys Ser  Pro His Ser Thr Val  Pro Glu His 
    1580                 1585                 1590             


His Pro  His Pro Ile Ser Pro  Tyr Glu His Leu Leu  Arg Gly Val 
    1595                 1600                 1605             


Ser Gly  Val Asp Leu Tyr Arg  Ser His Ile Pro Leu  Ala Phe Asp 
    1610                 1615                 1620             


Pro Thr  Ser Ile Pro Arg Gly  Ile Pro Leu Asp Ala  Ala Ala Ala 
    1625                 1630                 1635             


Tyr Tyr  Leu Pro Arg His Leu  Ala Pro Asn Pro Thr  Tyr Pro His 
    1640                 1645                 1650             


Leu Tyr  Pro Pro Tyr Leu Ile  Arg Gly Tyr Pro Asp  Thr Ala Ala 
    1655                 1660                 1665             


Leu Glu  Asn Arg Gln Thr Ile  Ile Asn Asp Tyr Ile  Thr Ser Gln 
    1670                 1675                 1680             


Gln Met  His His Asn Ala Ala  Thr Ala Met Ala Gln  Arg Ala Asp 
    1685                 1690                 1695             


Met Leu  Arg Gly Leu Ser Pro  Arg Glu Ser Ser Leu  Ala Leu Asn 
    1700                 1705                 1710             


Tyr Ala  Ala Gly Pro Arg Gly  Ile Ile Asp Leu Ser  Gln Val Pro 
    1715                 1720                 1725             


His Leu  Pro Val Leu Val Pro  Pro Thr Pro Gly Thr  Pro Ala Thr 
    1730                 1735                 1740             


Ala Met  Asp Arg Leu Ala Tyr  Leu Pro Thr Ala Pro  Gln Pro Phe 
    1745                 1750                 1755             


Ser Ser  Arg His Ser Ser Ser  Pro Leu Ser Pro Gly  Gly Pro Thr 
    1760                 1765                 1770             


His Leu  Thr Lys Pro Thr Thr  Thr Ser Ser Ser Glu  Arg Glu Arg 
    1775                 1780                 1785             


Asp Arg  Asp Arg Glu Arg Asp  Arg Asp Arg Glu Arg  Glu Lys Ser 
    1790                 1795                 1800             


Ile Leu  Thr Ser Thr Thr Thr  Val Glu His Ala Pro  Ile Trp Arg 
    1805                 1810                 1815             


Pro Gly  Thr Glu Gln Ser Ser  Gly Ser Ser Gly Gly  Gly Gly Gly 
    1820                 1825                 1830             


Ser Ser  Ser Arg Pro Ala Ser  His Ser His Ala His  Gln His Ser 
    1835                 1840                 1845             


Pro Ile  Ser Pro Arg Thr Gln  Asp Ala Leu Gln Gln  Arg Pro Ser 
    1850                 1855                 1860             


Val Leu  His Asn Thr Gly Met  Lys Gly Ile Ile Thr  Ala Val Glu 
    1865                 1870                 1875             


Pro Ser  Thr Pro Thr Val Leu  Arg Ser Thr Ser Thr  Ser Ser Pro 
    1880                 1885                 1890             


Val Arg  Pro Ala Ala Thr Phe  Pro Pro Ala Thr His  Cys Pro Leu 
    1895                 1900                 1905             


Gly Gly  Thr Leu Asp Gly Val  Tyr Pro Thr Leu Met  Glu Pro Val 
    1910                 1915                 1920             


Leu Leu  Pro Lys Glu Ala Pro  Arg Val Ala Arg Pro  Glu Arg Pro 
    1925                 1930                 1935             


Arg Ala  Asp Thr Gly His Ala  Phe Leu Ala Lys Pro  Pro Ala Arg 
    1940                 1945                 1950             


Ser Gly  Leu Glu Pro Ala Ser  Ser Pro Ser Lys Gly  Ser Glu Pro 
    1955                 1960                 1965             


Arg Pro  Leu Val Pro Pro Val  Ser Gly His Ala Thr  Ile Ala Arg 
    1970                 1975                 1980             


Thr Pro  Ala Lys Asn Leu Ala  Pro His His Ala Ser  Pro Asp Pro 
    1985                 1990                 1995             


Pro Ala  Pro Pro Ala Ser Ala  Ser Asp Pro His Arg  Glu Lys Thr 
    2000                 2005                 2010             


Gln Ser  Lys Pro Phe Ser Ile  Gln Glu Leu Glu Leu  Arg Ser Leu 
    2015                 2020                 2025             


Gly Tyr  His Gly Ser Ser Tyr  Ser Pro Glu Gly Val  Glu Pro Val 
    2030                 2035                 2040             


Ser Pro  Val Ser Ser Pro Ser  Leu Thr His Asp Lys  Gly Leu Pro 
    2045                 2050                 2055             


Lys His  Leu Glu Glu Leu Asp  Lys Ser His Leu Glu  Gly Glu Leu 
    2060                 2065                 2070             


Arg Pro  Lys Gln Pro Gly Pro  Val Lys Leu Gly Gly  Glu Ala Ala 
    2075                 2080                 2085             


His Leu  Pro His Leu Arg Pro  Leu Pro Glu Ser Gln  Pro Ser Ser 
    2090                 2095                 2100             


Ser Pro  Leu Leu Gln Thr Ala  Pro Gly Val Lys Gly  His Gln Arg 
    2105                 2110                 2115             


Val Val  Thr Leu Ala Gln His  Ile Ser Glu Val Ile  Thr Gln Asp 
    2120                 2125                 2130             


Tyr Thr  Arg His His Pro Gln  Gln Leu Ser Ala Pro  Leu Pro Ala 
    2135                 2140                 2145             


Pro Leu  Tyr Ser Phe Pro Gly  Ala Ser Cys Pro Val  Leu Asp Leu 
    2150                 2155                 2160             


Arg Arg  Pro Pro Ser Asp Leu  Tyr Leu Pro Pro Pro  Asp His Gly 
    2165                 2170                 2175             


Ala Pro  Ala Arg Gly Ser Pro  His Ser Glu Gly Gly  Lys Arg Ser 
    2180                 2185                 2190             


Pro Glu  Pro Asn Lys Thr Ser  Val Leu Gly Gly Gly  Glu Asp Gly 
    2195                 2200                 2205             


Ile Glu  Pro Val Ser Pro Pro  Glu Gly Met Thr Glu  Pro Gly His 
    2210                 2215                 2220             


Ser Arg  Ser Ala Val Tyr Pro  Leu Leu Tyr Arg Asp  Gly Glu Gln 
    2225                 2230                 2235             


Thr Glu  Pro Ser Arg Met Gly  Ser Lys Ser Pro Gly  Asn Thr Ser 
    2240                 2245                 2250             


Gln Pro  Pro Ala Phe Phe Ser  Lys Leu Thr Glu Ser  Asn Ser Ala 
    2255                 2260                 2265             


Met Val  Lys Ser Lys Lys Gln  Glu Ile Asn Lys Lys  Leu Asn Thr 
    2270                 2275                 2280             


His Asn  Arg Asn Glu Pro Glu  Tyr Asn Ile Ser Gln  Pro Gly Thr 
    2285                 2290                 2295             


Glu Ile  Phe Asn Met Pro Ala  Ile Thr Gly Thr Gly  Leu Met Thr 
    2300                 2305                 2310             


Tyr Arg  Ser Gln Ala Val Gln  Glu His Ala Ser Thr  Asn Met Gly 
    2315                 2320                 2325             


Leu Glu  Ala Ile Ile Arg Lys  Ala Leu Met Gly Gly  Gly Gly Lys 
    2330                 2335                 2340             


Ala Lys  Val Ser Gly Arg Pro  Ser Ser Arg Lys Ala  Lys Ser Pro 
    2345                 2350                 2355             


Ala Pro  Gly Leu Ala Ser Gly  Asp Arg Pro Pro Ser  Val Ser Ser 
    2360                 2365                 2370             


Val His  Ser Glu Gly Asp Cys  Asn Arg Arg Thr Pro  Leu Thr Asn 
    2375                 2380                 2385             


Arg Val  Trp Glu Asp Arg Pro  Ser Ser Ala Gly Ser  Thr Pro Phe 
    2390                 2395                 2400             


Pro Tyr  Asn Pro Leu Ile Met  Arg Leu Gln Ala Gly  Val Met Ala 
    2405                 2410                 2415             


Ser Pro  Pro Pro Pro Gly Leu  Pro Ala Gly Ser Gly  Pro Leu Ala 
    2420                 2425                 2430             


Gly Pro  His His Ala Trp Asp  Glu Glu Pro Lys Pro  Leu Leu Cys 
    2435                 2440                 2445             


Ser Gln  Tyr Glu Thr Leu Ser  Asp Ser Glu 
    2450                 2455             


<210>  38
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Glu Lys Pro Lys Leu His Tyr Phe Asn Ala Arg Gly Arg Met 
1               5                   10                  15      


Glu Ser Thr Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu 
            20                  25                  30          


Lys Phe Ile Lys Ser Ala Glu Asp Leu Asp Lys Leu Arg Asn Asp Gly 
        35                  40                  45              


Tyr Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
65                  70                  75                  80  


Leu Tyr Gly Lys Asp Ile Lys Glu Arg Ala Leu Ile Asp Met Tyr Ile 
                85                  90                  95      


Glu Gly Ile Ala Asp Leu Gly Glu Met Ile Leu Leu Leu Pro Val Cys 
            100                 105                 110         


Pro Pro Glu Glu Lys Asp Ala Lys Leu Ala Leu Ile Lys Glu Lys Ile 
        115                 120                 125             


Lys Asn Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Lys Ser His Gly 
    130                 135                 140                 


Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Arg Ala Asp Ile His Leu 
145                 150                 155                 160 


Val Glu Leu Leu Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                165                 170                 175     


Ser Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
            180                 185                 190         


Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Pro Arg Lys Pro Pro Met 
        195                 200                 205             


Asp Glu Lys Ser Leu Glu Glu Ala Arg Lys Ile Phe Arg Phe 
    210                 215                 220         


<210>  39
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Val Ser Thr Gly Val Lys Val Pro Arg Asn Phe Arg Leu Leu 
1               5                   10                  15      


Glu Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr Val Ser 
            20                  25                  30          


Trp Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp Thr Gly 
        35                  40                  45              


Met Ile Ile Gly Pro Pro Arg Thr Asn Tyr Glu Asn Arg Ile Tyr Ser 
    50                  55                  60                  


Leu Lys Val Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro Ser Val 
65                  70                  75                  80  


Arg Phe Val Thr Lys Ile Asn Met Asn Gly Ile Asn Asn Ser Ser Gly 
                85                  90                  95      


Met Val Asp Ala Arg Ser Ile Pro Val Leu Ala Lys Trp Gln Asn Ser 
            100                 105                 110         


Tyr Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met Met Ser 
        115                 120                 125             


Lys Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Thr Tyr Asn 
    130                 135                 140                 


Asn 
145 


<210>  40
<211>  1541
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Lys Asp Lys Gln Lys Lys Lys Lys Glu Arg Thr Trp Ala Glu Ala 
1               5                   10                  15      


Ala Arg Leu Val Leu Glu Asn Tyr Ser Asp Ala Pro Met Thr Pro Lys 
            20                  25                  30          


Gln Ile Leu Gln Val Ile Glu Ala Glu Gly Leu Lys Glu Met Arg Ser 
        35                  40                  45              


Gly Thr Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Ser Asn Ser 
    50                  55                  60                  


Arg Gly Gly Glu Gly Leu Phe Tyr Lys Leu Pro Gly Arg Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Leu Lys Lys Asp Ala Leu Gln Trp Ser Arg His Pro Ala Thr 
                85                  90                  95      


Val Glu Gly Glu Glu Pro Glu Asp Thr Ala Asp Val Glu Ser Cys Gly 
            100                 105                 110         


Ser Asn Glu Ala Ser Thr Val Ser Gly Glu Asn Asp Val Ser Leu Asp 
        115                 120                 125             


Glu Thr Ser Ser Asn Ala Ser Cys Ser Thr Glu Ser Gln Ser Arg Pro 
    130                 135                 140                 


Leu Ser Asn Pro Arg Asp Ser Tyr Arg Ala Ser Ser Gln Ala Asn Lys 
145                 150                 155                 160 


Gln Lys Lys Lys Thr Gly Val Met Leu Pro Arg Val Val Leu Thr Pro 
                165                 170                 175     


Leu Lys Val Asn Gly Ala His Val Glu Ser Ala Ser Gly Phe Ser Gly 
            180                 185                 190         


Cys His Ala Asp Gly Glu Ser Gly Ser Pro Ser Ser Ser Ser Ser Gly 
        195                 200                 205             


Ser Leu Ala Leu Gly Ser Ala Ala Ile Arg Gly Gln Ala Glu Val Thr 
    210                 215                 220                 


Gln Asp Pro Ala Pro Leu Leu Arg Gly Phe Arg Lys Pro Ala Thr Gly 
225                 230                 235                 240 


Gln Met Lys Arg Asn Arg Gly Glu Glu Ile Asp Phe Glu Thr Pro Gly 
                245                 250                 255     


Ser Ile Leu Val Asn Thr Asn Leu Arg Ala Leu Ile Asn Ser Arg Thr 
            260                 265                 270         


Phe His Ala Leu Pro Ser His Phe Gln Gln Gln Leu Leu Phe Leu Leu 
        275                 280                 285             


Pro Glu Val Asp Arg Gln Val Gly Thr Asp Gly Leu Leu Arg Leu Ser 
    290                 295                 300                 


Ser Ser Ala Leu Asn Asn Glu Phe Phe Thr His Ala Ala Gln Ser Trp 
305                 310                 315                 320 


Arg Glu Arg Leu Ala Asp Gly Glu Phe Thr His Glu Met Gln Val Arg 
                325                 330                 335     


Ile Arg Gln Glu Met Glu Lys Glu Lys Lys Val Glu Gln Trp Lys Glu 
            340                 345                 350         


Lys Phe Phe Glu Asp Tyr Tyr Gly Gln Lys Leu Gly Leu Thr Lys Glu 
        355                 360                 365             


Glu Ser Leu Gln Gln Asn Val Gly Gln Glu Glu Ala Glu Ile Lys Ser 
    370                 375                 380                 


Gly Leu Cys Val Pro Gly Glu Ser Val Arg Ile Gln Arg Gly Pro Ala 
385                 390                 395                 400 


Thr Arg Gln Arg Asp Gly His Phe Lys Lys Arg Ser Arg Pro Asp Leu 
                405                 410                 415     


Arg Thr Arg Ala Arg Arg Asn Leu Tyr Lys Lys Gln Glu Ser Glu Gln 
            420                 425                 430         


Ala Gly Val Ala Lys Asp Ala Lys Ser Val Ala Ser Asp Val Pro Leu 
        435                 440                 445             


Tyr Lys Asp Gly Glu Ala Lys Thr Asp Pro Ala Gly Leu Ser Ser Pro 
    450                 455                 460                 


His Leu Pro Gly Thr Ser Ser Ala Ala Pro Asp Leu Glu Gly Pro Glu 
465                 470                 475                 480 


Phe Pro Val Glu Ser Val Ala Ser Arg Ile Gln Ala Glu Pro Asp Asn 
                485                 490                 495     


Leu Ala Arg Ala Ser Ala Ser Pro Asp Arg Ile Pro Ser Leu Pro Gln 
            500                 505                 510         


Glu Thr Val Asp Gln Glu Pro Lys Asp Gln Lys Arg Lys Ser Phe Glu 
        515                 520                 525             


Gln Ala Ala Ser Ala Ser Phe Pro Glu Lys Lys Pro Arg Leu Glu Asp 
    530                 535                 540                 


Arg Gln Ser Phe Arg Asn Thr Ile Glu Ser Val His Thr Glu Lys Pro 
545                 550                 555                 560 


Gln Pro Thr Lys Glu Glu Pro Lys Val Pro Pro Ile Arg Ile Gln Leu 
                565                 570                 575     


Ser Arg Ile Lys Pro Pro Trp Val Val Lys Gly Gln Pro Thr Tyr Gln 
            580                 585                 590         


Ile Cys Pro Arg Ile Ile Pro Thr Thr Glu Ser Ser Cys Arg Gly Trp 
        595                 600                 605             


Thr Gly Ala Arg Thr Leu Ala Asp Ile Lys Ala Arg Ala Leu Gln Val 
    610                 615                 620                 


Arg Gly Ala Arg Gly His His Cys His Arg Glu Ala Ala Thr Thr Ala 
625                 630                 635                 640 


Ile Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Ala Thr Asp 
                645                 650                 655     


Glu Gly Gly Gly Arg Gly Ser Ser Ser Gly Asp Gly Gly Glu Ala Cys 
            660                 665                 670         


Gly His Pro Glu Pro Arg Gly Gly Pro Ser Thr Pro Gly Lys Cys Thr 
        675                 680                 685             


Ser Asp Leu Gln Arg Thr Gln Leu Leu Pro Pro Tyr Pro Leu Asn Gly 
    690                 695                 700                 


Glu His Thr Gln Ala Gly Thr Ala Met Ser Arg Ala Arg Arg Glu Asp 
705                 710                 715                 720 


Leu Pro Ser Leu Arg Lys Glu Glu Ser Cys Leu Leu Gln Arg Ala Thr 
                725                 730                 735     


Val Gly Leu Thr Asp Gly Leu Gly Asp Ala Ser Gln Leu Pro Val Ala 
            740                 745                 750         


Pro Thr Gly Asp Gln Pro Cys Gln Ala Leu Pro Leu Leu Ser Ser Gln 
        755                 760                 765             


Thr Ser Val Ala Glu Arg Leu Val Glu Gln Pro Gln Leu His Pro Asp 
    770                 775                 780                 


Val Arg Thr Glu Cys Glu Ser Gly Thr Thr Ser Trp Glu Ser Asp Asp 
785                 790                 795                 800 


Glu Glu Gln Gly Pro Thr Val Pro Ala Asp Asn Gly Pro Ile Pro Ser 
                805                 810                 815     


Leu Val Gly Asp Asp Thr Leu Glu Lys Gly Thr Gly Gln Ala Leu Asp 
            820                 825                 830         


Ser His Pro Thr Met Lys Asp Pro Val Asn Val Thr Pro Ser Ser Thr 
        835                 840                 845             


Pro Glu Ser Ser Pro Thr Asp Cys Leu Gln Asn Arg Ala Phe Asp Asp 
    850                 855                 860                 


Glu Leu Gly Leu Gly Gly Ser Cys Pro Pro Met Arg Glu Ser Asp Thr 
865                 870                 875                 880 


Arg Gln Glu Asn Leu Lys Thr Lys Ala Leu Val Ser Asn Ser Ser Leu 
                885                 890                 895     


His Trp Ile Pro Ile Pro Ser Asn Asp Glu Val Val Lys Gln Pro Lys 
            900                 905                 910         


Pro Glu Ser Arg Glu His Ile Pro Ser Val Glu Pro Gln Val Gly Glu 
        915                 920                 925             


Glu Trp Glu Lys Ala Ala Pro Thr Pro Pro Ala Leu Pro Gly Asp Leu 
    930                 935                 940                 


Thr Ala Glu Glu Gly Leu Asp Pro Leu Asp Ser Leu Thr Ser Leu Trp 
945                 950                 955                 960 


Thr Val Pro Ser Arg Gly Gly Ser Asp Ser Asn Gly Ser Tyr Cys Gln 
                965                 970                 975     


Gln Val Asp Ile Glu Lys Leu Lys Ile Asn Gly Asp Ser Glu Ala Leu 
            980                 985                 990         


Ser Pro His Gly Glu Ser Thr Asp  Thr Ala Ser Asp Phe  Glu Gly His 
        995                 1000                 1005             


Leu Thr  Glu Asp Ser Ser Glu  Ala Asp Thr Arg Glu  Ala Ala Val 
    1010                 1015                 1020             


Thr Lys  Gly Ser Ser Val Asp  Lys Asp Glu Lys Pro  Asn Trp Asn 
    1025                 1030                 1035             


Gln Ser  Ala Pro Leu Ser Lys  Val Asn Gly Asp Met  Arg Leu Val 
    1040                 1045                 1050             


Thr Arg  Thr Asp Gly Met Val  Ala Pro Gln Ser Trp  Val Ser Arg 
    1055                 1060                 1065             


Val Cys  Ala Val Arg Gln Lys  Ile Pro Asp Ser Leu  Leu Leu Ala 
    1070                 1075                 1080             


Ser Thr  Glu Tyr Gln Pro Arg  Ala Val Cys Leu Ser  Met Pro Gly 
    1085                 1090                 1095             


Ser Ser  Val Glu Ala Thr Asn  Pro Leu Val Met Gln  Leu Leu Gln 
    1100                 1105                 1110             


Gly Ser  Leu Pro Leu Glu Lys  Val Leu Pro Pro Ala  His Asp Asp 
    1115                 1120                 1125             


Ser Met  Ser Glu Ser Pro Gln  Val Pro Leu Thr Lys  Asp Gln Ser 
    1130                 1135                 1140             


His Gly  Ser Leu Arg Met Gly  Ser Leu His Gly Leu  Gly Lys Asn 
    1145                 1150                 1155             


Ser Gly  Met Val Asp Gly Ser  Ser Pro Ser Ser Leu  Arg Ala Leu 
    1160                 1165                 1170             


Lys Glu  Pro Leu Leu Pro Asp  Ser Cys Glu Thr Gly  Thr Gly Leu 
    1175                 1180                 1185             


Ala Arg  Ile Glu Ala Thr Gln  Ala Pro Gly Ala Pro  Gln Lys Asn 
    1190                 1195                 1200             


Cys Lys  Ala Val Pro Ser Phe  Asp Ser Leu His Pro  Val Thr Asn 
    1205                 1210                 1215             


Pro Ile  Thr Ser Ser Arg Lys  Leu Glu Glu Met Asp  Ser Lys Glu 
    1220                 1225                 1230             


Gln Phe  Ser Ser Phe Ser Cys  Glu Asp Gln Lys Glu  Val Arg Ala 
    1235                 1240                 1245             


Met Ser  Gln Asp Ser Asn Ser  Asn Ala Ala Pro Gly  Lys Ser Pro 
    1250                 1255                 1260             


Gly Asp  Leu Thr Thr Ser Arg  Thr Pro Arg Phe Ser  Ser Pro Asn 
    1265                 1270                 1275             


Val Ile  Ser Phe Gly Pro Glu  Gln Thr Gly Arg Ala  Leu Gly Asp 
    1280                 1285                 1290             


Gln Ser  Asn Val Thr Gly Gln  Gly Lys Lys Leu Phe  Gly Ser Gly 
    1295                 1300                 1305             


Asn Val  Ala Ala Thr Leu Gln  Arg Pro Arg Pro Ala  Asp Pro Met 
    1310                 1315                 1320             


Pro Leu  Pro Ala Glu Ile Pro  Pro Val Phe Pro Ser  Gly Lys Leu 
    1325                 1330                 1335             


Gly Pro  Ser Thr Asn Ser Met  Ser Gly Gly Val Gln  Thr Pro Arg 
    1340                 1345                 1350             


Glu Asp  Trp Ala Pro Lys Pro  His Ala Phe Val Gly  Ser Val Lys 
    1355                 1360                 1365             


Asn Glu  Lys Thr Phe Val Gly  Gly Pro Leu Lys Ala  Asn Ala Glu 
    1370                 1375                 1380             


Asn Arg  Lys Ala Thr Gly His  Ser Pro Leu Glu Leu  Val Gly His 
    1385                 1390                 1395             


Leu Glu  Gly Met Pro Phe Val  Met Asp Leu Pro Phe  Trp Lys Leu 
    1400                 1405                 1410             


Pro Arg  Glu Pro Gly Lys Gly  Leu Ser Glu Pro Leu  Glu Pro Ser 
    1415                 1420                 1425             


Ser Leu  Pro Ser Gln Leu Ser  Ile Lys Gln Ala Phe  Tyr Gly Lys 
    1430                 1435                 1440             


Leu Ser  Lys Leu Gln Leu Ser  Ser Thr Ser Phe Asn  Tyr Ser Ser 
    1445                 1450                 1455             


Ser Ser  Pro Thr Phe Pro Lys  Gly Leu Ala Gly Ser  Val Val Gln 
    1460                 1465                 1470             


Leu Ser  His Lys Ala Asn Phe  Gly Ala Ser His Ser  Ala Ser Leu 
    1475                 1480                 1485             


Ser Leu  Gln Met Phe Thr Asp  Ser Ser Thr Val Glu  Ser Ile Ser 
    1490                 1495                 1500             


Leu Gln  Cys Ala Cys Ser Leu  Lys Ala Met Ile Met  Cys Gln Gly 
    1505                 1510                 1515             


Cys Gly  Ala Phe Cys His Asp  Asp Cys Ile Gly Pro  Ser Lys Leu 
    1520                 1525                 1530             


Cys Val  Leu Cys Leu Val Val  Arg 
    1535                 1540     


<210>  41
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ser Asp Gln Asp His Ser Met Asp Glu Met Thr Ala Val Val Lys 
1               5                   10                  15      


Ile Glu Lys Gly Val Gly Gly Asn Asn Gly Gly Asn Gly Asn Gly Gly 
            20                  25                  30          


Gly Ala Phe Ser Gln Ala Arg Ser Ser Ser Thr Gly Ser Ser Ser Ser 
        35                  40                  45              


Thr Gly Gly Gly Gly Gln Glu Ser Gln Pro Ser Pro Leu Ala Leu Leu 
    50                  55                  60                  


Ala Ala Thr Cys Ser Arg Ile Glu Ser Pro Asn Glu Asn Ser Asn Asn 
65                  70                  75                  80  


Ser Gln Gly Pro Ser Gln Ser Gly Gly Thr Gly Glu Leu Asp Leu Thr 
                85                  90                  95      


Ala Thr Gln Leu Ser Gln Gly Ala Asn Gly Trp Gln Ile Ile Ser Ser 
            100                 105                 110         


Ser Ser Gly Ala Thr Pro Thr Ser Lys Glu Gln Ser Gly Ser Ser Thr 
        115                 120                 125             


Asn Gly Ser Asn Gly Ser Glu Ser Ser Lys Asn Arg Thr Val Ser Gly 
    130                 135                 140                 


Gly Gln Tyr Val Val Ala Ala Ala Pro Asn Leu Gln Asn Gln Gln Val 
145                 150                 155                 160 


Leu Thr Gly Leu Pro Gly Val Met Pro Asn Ile Gln Tyr Gln Val Ile 
                165                 170                 175     


Pro Gln Phe Gln Thr Val Asp Gly Gln Gln Leu Gln Phe Ala Ala Thr 
            180                 185                 190         


Gly Ala Gln Val Gln Gln Asp Gly Ser Gly Gln Ile Gln Ile Ile Pro 
        195                 200                 205             


Gly Ala Asn Gln Gln Ile Ile Thr Asn Arg Gly Ser Gly Gly Asn Ile 
    210                 215                 220                 


Ile Ala Ala Met Pro Asn Leu Leu Gln Gln Ala Val Pro Leu Gln Gly 
225                 230                 235                 240 


Leu Ala Asn Asn Val Leu Ser Gly Gln Thr Gln Tyr Val Thr Asn Val 
                245                 250                 255     


Pro Val Ala Leu Asn Gly Asn Ile Thr Leu Leu Pro Val Asn Ser Val 
            260                 265                 270         


Ser Ala Ala Thr Leu Thr Pro Ser Ser Gln Ala Val Thr Ile Ser Ser 
        275                 280                 285             


Ser Gly Ser Gln Glu Ser Gly Ser Gln Pro Val Thr Ser Gly Thr Thr 
    290                 295                 300                 


Ile Ser Ser Ala Ser Leu Val Ser Ser Gln Ala Ser Ser Ser Ser Phe 
305                 310                 315                 320 


Phe Thr Asn Ala Asn Ser Tyr Ser Thr Thr Thr Thr Thr Ser Asn Met 
                325                 330                 335     


Gly Ile Met Asn Phe Thr Thr Ser Gly Ser Ser Gly Thr Asn Ser Gln 
            340                 345                 350         


Gly Gln Thr Pro Gln Arg Val Ser Gly Leu Gln Gly Ser Asp Ala Leu 
        355                 360                 365             


Asn Ile Gln Gln Asn Gln Thr Ser Gly Gly Ser Leu Gln Ala Gly Gln 
    370                 375                 380                 


Gln Lys Glu Gly Glu Gln Asn Gln Gln Thr Gln Gln Gln Gln Ile Leu 
385                 390                 395                 400 


Ile Gln Pro Gln Leu Val Gln Gly Gly Gln Ala Leu Gln Ala Leu Gln 
                405                 410                 415     


Ala Ala Pro Leu Ser Gly Gln Thr Phe Thr Thr Gln Ala Ile Ser Gln 
            420                 425                 430         


Glu Thr Leu Gln Asn Leu Gln Leu Gln Ala Val Pro Asn Ser Gly Pro 
        435                 440                 445             


Ile Ile Ile Arg Thr Pro Thr Val Gly Pro Asn Gly Gln Val Ser Trp 
    450                 455                 460                 


Gln Thr Leu Gln Leu Gln Asn Leu Gln Val Gln Asn Pro Gln Ala Gln 
465                 470                 475                 480 


Thr Ile Thr Leu Ala Pro Met Gln Gly Val Ser Leu Gly Gln Thr Ser 
                485                 490                 495     


Ser Ser Asn Thr Thr Leu Thr Pro Ile Ala Ser Ala Ala Ser Ile Pro 
            500                 505                 510         


Ala Gly Thr Val Thr Val Asn Ala Ala Gln Leu Ser Ser Met Pro Gly 
        515                 520                 525             


Leu Gln Thr Ile Asn Leu Ser Ala Leu Gly Thr Ser Gly Ile Gln Val 
    530                 535                 540                 


His Pro Ile Gln Gly Leu Pro Leu Ala Ile Ala Asn Ala Pro Gly Asp 
545                 550                 555                 560 


His Gly Ala Gln Leu Gly Leu His Gly Ala Gly Gly Asp Gly Ile His 
                565                 570                 575     


Asp Asp Thr Ala Gly Gly Glu Glu Gly Glu Asn Ser Pro Asp Ala Gln 
            580                 585                 590         


Pro Gln Ala Gly Arg Arg Thr Arg Arg Glu Ala Cys Thr Cys Pro Tyr 
        595                 600                 605             


Cys Lys Asp Ser Glu Gly Arg Gly Ser Gly Asp Pro Gly Lys Lys Lys 
    610                 615                 620                 


Gln His Ile Cys His Ile Gln Gly Cys Gly Lys Val Tyr Gly Lys Thr 
625                 630                 635                 640 


Ser His Leu Arg Ala His Leu Arg Trp His Thr Gly Glu Arg Pro Phe 
                645                 650                 655     


Met Cys Thr Trp Ser Tyr Cys Gly Lys Arg Phe Thr Arg Ser Asp Glu 
            660                 665                 670         


Leu Gln Arg His Lys Arg Thr His Thr Gly Glu Lys Lys Phe Ala Cys 
        675                 680                 685             


Pro Glu Cys Pro Lys Arg Phe Met Arg Ser Asp His Leu Ser Lys His 
    690                 695                 700                 


Ile Lys Thr His Gln Asn Lys Lys Gly Gly Pro Gly Val Ala Leu Ser 
705                 710                 715                 720 


Val Gly Thr Leu Pro Leu Asp Ser Gly Ala Gly Ser Glu Gly Ser Gly 
                725                 730                 735     


Thr Ala Thr Pro Ser Ala Leu Ile Thr Thr Asn Met Val Ala Met Glu 
            740                 745                 750         


Ala Ile Cys Pro Glu Gly Ile Ala Arg Leu Ala Asn Ser Gly Ile Asn 
        755                 760                 765             


Val Met Gln Val Ala Asp Leu Gln Ser Ile Asn Ile Ser Gly Asn Gly 
    770                 775                 780                 


Phe 
785 


<210>  42
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Lys Leu Lys Leu Lys Asn Val Phe Leu Ala Tyr Phe Leu Val Ser 
1               5                   10                  15      


Ile Ala Gly Leu Leu Tyr Ala Leu Val Gln Leu Gly Gln Pro Cys Asp 
            20                  25                  30          


Cys Leu Pro Pro Leu Arg Ala Ala Ala Glu Gln Leu Arg Gln Lys Asp 
        35                  40                  45              


Leu Arg Ile Ser Gln Leu Gln Ala Glu Leu Arg Arg Pro Pro Pro Ala 
    50                  55                  60                  


Pro Ala Gln Pro Pro Glu Pro Glu Ala Leu Pro Thr Ile Tyr Val Val 
65                  70                  75                  80  


Thr Pro Thr Tyr Ala Arg Leu Val Gln Lys Ala Glu Leu Val Arg Leu 
                85                  90                  95      


Ser Gln Thr Leu Ser Leu Val Pro Arg Leu His Trp Leu Leu Val Glu 
            100                 105                 110         


Asp Ala Glu Gly Pro Thr Pro Leu Val Ser Gly Leu Leu Ala Ala Ser 
        115                 120                 125             


Gly Leu Leu Phe Thr His Leu Val Val Leu Thr Pro Lys Ala Gln Arg 
    130                 135                 140                 


Leu Arg Glu Gly Glu Pro Gly Trp Val His Pro Arg Gly Val Glu Gln 
145                 150                 155                 160 


Arg Asn Lys Ala Leu Asp Trp Leu Arg Gly Arg Gly Gly Ala Val Gly 
                165                 170                 175     


Gly Glu Lys Asp Pro Pro Pro Pro Gly Thr Gln Gly Val Val Tyr Phe 
            180                 185                 190         


Ala Asp Asp Asp Asn Thr Tyr Ser Arg Glu Leu Phe Glu Glu Met Arg 
        195                 200                 205             


Trp Thr Arg Gly Val Ser Val Trp Pro Val Gly Leu Val Gly Gly Leu 
    210                 215                 220                 


Arg Phe Glu Gly Pro Gln Val Gln Asp Gly Arg Val Val Gly Phe His 
225                 230                 235                 240 


Thr Ala Trp Glu Pro Ser Arg Pro Phe Pro Val Asp Met Ala Gly Phe 
                245                 250                 255     


Ala Val Ala Leu Pro Leu Leu Leu Asp Lys Pro Asn Ala Gln Phe Asp 
            260                 265                 270         


Ser Thr Ala Pro Arg Gly His Leu Glu Ser Ser Leu Leu Ser His Leu 
        275                 280                 285             


Val Asp Pro Lys Asp Leu Glu Pro Arg Ala Ala Asn Cys Thr Arg Val 
    290                 295                 300                 


Leu Val Trp His Thr Arg Thr Glu Lys Pro Lys Met Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Leu Gln Arg Gln Gly Arg Gly Ser Asp Pro Ala Ile Glu Val 
                325                 330                 335 


<210>  43
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Thr Arg Glu Cys Pro Ser Pro Ala Pro Gly Pro Gly Ala Pro Leu 
1               5                   10                  15      


Ser Gly Ser Val Leu Ala Glu Ala Ala Val Val Phe Ala Val Val Leu 
            20                  25                  30          


Ser Ile His Ala Thr Val Trp Asp Arg Tyr Ser Trp Cys Ala Val Ala 
        35                  40                  45              


Leu Ala Val Gln Ala Phe Tyr Val Gln Tyr Lys Trp Asp Arg Leu Leu 
    50                  55                  60                  


Gln Gln Gly Ser Ala Val Phe Gln Phe Arg Met Ser Ala Asn Ser Gly 
65                  70                  75                  80  


Leu Leu Pro Ala Ser Met Val Met Pro Leu Leu Gly Leu Val Met Lys 
                85                  90                  95      


Glu Arg Cys Gln Thr Ala Gly Asn Pro Phe Phe Glu Arg Phe Gly Ile 
            100                 105                 110         


Val Val Ala Ala Thr Gly Met Ala Val Ala Leu Phe Ser Ser Val Leu 
        115                 120                 125             


Ala Leu Gly Ile Thr Arg Pro Val Pro Thr Asn Thr Cys Val Ile Leu 
    130                 135                 140                 


Gly Leu Ala Gly Gly Val Ile Ile Tyr Ile Met Lys His Ser Leu Ser 
145                 150                 155                 160 


Val Gly Glu Val Ile Glu Val Leu Glu Val Leu Leu Ile Phe Val Tyr 
                165                 170                 175     


Leu Asn Met Ile Leu Leu Tyr Leu Leu Pro Arg Cys Phe Thr Pro Gly 
            180                 185                 190         


Glu Ala Leu Leu Val Leu Gly Gly Ile Ser Phe Val Leu Asn Gln Leu 
        195                 200                 205             


Ile Lys Arg Ser Leu Thr Leu Val Glu Ser Gln Gly Asp Pro Val Asp 
    210                 215                 220                 


Phe Phe Leu Leu Val Val Val Val Gly Met Val Leu Met Gly Ile Phe 
225                 230                 235                 240 


Phe Ser Thr Leu Phe Val Phe Met Asp Ser Gly Thr Trp Ala Ser Ser 
                245                 250                 255     


Ile Phe Phe His Leu Met Thr Cys Val Leu Ser Leu Gly Val Val Leu 
            260                 265                 270         


Pro Trp Leu His Arg Leu Ile Arg Arg Asn Pro Leu Leu Trp Leu Leu 
        275                 280                 285             


Gln Phe Leu Phe Gln Thr Asp Thr Arg Ile Tyr Leu Leu Ala Tyr Trp 
    290                 295                 300                 


Ser Leu Leu Ala Thr Leu Ala Cys Leu Val Val Leu Tyr Gln Asn Ala 
305                 310                 315                 320 


Lys Arg Ser Ser Ser Glu Ser Lys Lys His Gln Ala Pro Thr Ile Ala 
                325                 330                 335     


Arg Lys Tyr Phe His Leu Ile Val Val Ala Thr Tyr Ile Pro Gly Ile 
            340                 345                 350         


Ile Phe Asp Arg Pro Leu Leu Tyr Val Ala Ala Thr Val Cys Leu Ala 
        355                 360                 365             


Val Phe Ile Phe Leu Glu Tyr Val Arg Tyr Phe Arg Ile Lys Pro Leu 
    370                 375                 380                 


Gly His Thr Leu Arg Ser Phe Leu Ser Leu Phe Leu Asp Glu Arg Asp 
385                 390                 395                 400 


Ser Gly Pro Leu Ile Leu Thr His Ile Tyr Leu Leu Leu Gly Met Ser 
                405                 410                 415     


Leu Pro Ile Trp Leu Ile Pro Arg Pro Cys Thr Gln Lys Gly Ser Leu 
            420                 425                 430         


Gly Gly Ala Arg Ala Leu Val Pro Tyr Ala Gly Val Leu Ala Val Gly 
        435                 440                 445             


Val Gly Asp Thr Val Ala Ser Ile Phe Gly Ser Thr Met Gly Glu Ile 
    450                 455                 460                 


Arg Trp Pro Gly Thr Lys Lys Thr Phe Glu Gly Thr Met Thr Ser Ile 
465                 470                 475                 480 


Phe Ala Gln Ile Ile Ser Val Ala Leu Ile Leu Ile Phe Asp Ser Gly 
                485                 490                 495     


Val Asp Leu Asn Tyr Ser Tyr Ala Trp Ile Leu Gly Ser Ile Ser Thr 
            500                 505                 510         


Val Ser Leu Leu Glu Ala Tyr Thr Thr Gln Ile Asp Asn Leu Leu Leu 
        515                 520                 525             


Pro Leu Tyr Leu Leu Ile Leu Leu Met Ala 
    530                 535             


<210>  44
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asn Ser Glu Leu Asp Tyr Tyr Glu Lys Phe Glu Glu Val His Gly 
1               5                   10                  15      


Ile Leu Met Tyr Lys Asp Phe Val Lys Tyr Trp Asp Asn Val Glu Ala 
            20                  25                  30          


Phe Gln Ala Arg Pro Asp Asp Leu Val Ile Ala Thr Tyr Pro Lys Ser 
        35                  40                  45              


Gly Thr Thr Trp Val Ser Glu Ile Val Tyr Met Ile Tyr Lys Glu Gly 
    50                  55                  60                  


Asp Val Glu Lys Cys Lys Glu Asp Val Ile Phe Asn Arg Ile Pro Phe 
65                  70                  75                  80  


Leu Glu Cys Arg Lys Glu Asn Leu Met Asn Gly Val Lys Gln Leu Asp 
                85                  90                  95      


Glu Met Asn Ser Pro Arg Ile Val Lys Thr His Leu Pro Pro Glu Leu 
            100                 105                 110         


Leu Pro Ala Ser Phe Trp Glu Lys Asp Cys Lys Ile Ile Tyr Leu Cys 
        115                 120                 125             


Arg Asn Ala Lys Asp Val Ala Val Ser Phe Tyr Tyr Phe Phe Leu Met 
    130                 135                 140                 


Val Ala Gly His Pro Asn Pro Gly Ser Phe Pro Glu Phe Val Glu Lys 
145                 150                 155                 160 


Phe Met Gln Gly Gln Val Pro Tyr Gly Ser Trp Tyr Lys His Val Lys 
                165                 170                 175     


Ser Trp Trp Glu Lys Gly Lys Ser Pro Arg Val Leu Phe Leu Phe Tyr 
            180                 185                 190         


Glu Asp Leu Lys Glu Asp Ile Arg Lys Glu Val Ile Lys Leu Ile His 
        195                 200                 205             


Phe Leu Glu Arg Lys Pro Ser Glu Glu Leu Val Asp Arg Ile Ile His 
    210                 215                 220                 


His Thr Ser Phe Gln Glu Met Lys Asn Asn Pro Ser Thr Asn Tyr Thr 
225                 230                 235                 240 


Thr Leu Pro Asp Glu Ile Met Asn Gln Lys Leu Ser Pro Phe Met Arg 
                245                 250                 255     


Lys Gly Ile Thr Gly Asp Trp Lys Asn His Phe Thr Val Ala Leu Asn 
            260                 265                 270         


Glu Lys Phe Asp Lys His Tyr Glu Gln Gln Met Lys Glu Ser Thr Leu 
        275                 280                 285             


Lys Phe Arg Thr Glu Ile 
    290                 


<210>  45
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Met  Lys Ser Ser Leu Ser  Ile Phe His Pro Gly  His Cys Leu 
    1220                 1225                 1230             


Lys Leu  
    1235 


<210>  46
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Val Leu Arg Val Gly Leu Cys Pro Gly Leu Thr Glu Glu Met 
1               5                   10                  15      


Ile Gln Leu Leu Arg Ser His Arg Ile Lys Thr Val Val Asp Leu Val 
            20                  25                  30          


Ser Ala Asp Leu Glu Glu Val Ala Gln Lys Cys Gly Leu Ser Tyr Lys 
        35                  40                  45              


Thr Trp Arg Ala His Ser Ser Gly Asn Leu Gly Gly Leu Gln Leu Pro 
    50                  55                  60                  


Gln Val Pro Ala Gly Arg Ser Trp Ser Gly Val Arg Asn Ala Leu Lys 
65                  70                  75                  80  


Lys Ala Gly Leu Gly His Gly Gly Thr Asp Gly Leu Ser Leu Asn Ala 
                85                  90                  95      


Phe Asp Glu Arg Gly Thr Ala Val Ser Thr Ser Arg Leu Asp Lys Leu 
            100                 105                 110         


Leu Asp Ala Gly Leu Tyr Thr Gly Glu Val Thr Glu Ile Val Gly Gly 
        115                 120                 125             


Pro Gly Ser Gly Lys Thr Gln Val Cys Leu Cys Met Ala Ala Asn Val 
    130                 135                 140                 


Ala His Gly Leu Gln Gln Asn Val Leu Tyr Val Asp Ser Asn Gly Gly 
145                 150                 155                 160 


Leu Thr Ala Ser Arg Leu Leu Gln Leu Leu Gln Ala Lys Thr Gln Asp 
                165                 170                 175     


Glu Glu Glu Gln Ala Glu Ala Leu Arg Arg Ile Gln Val Val His Ala 
            180                 185                 190         


Phe Asp Ile Phe Gln Met Leu Asp Val Leu Gln Glu Leu Arg Gly Thr 
        195                 200                 205             


Val Ala Gln Gln Val Thr Gly Ser Ser Gly Thr Val Lys Val Val Val 
    210                 215                 220                 


Val Asp Ser Val Thr Ala Val Val Ser Pro Leu Leu Gly Gly Gln Gln 
225                 230                 235                 240 


Arg Glu Gly Leu Ala Leu Met Met Gln Leu Ala Arg Glu Leu Lys Thr 
                245                 250                 255     


Leu Ala Arg Asp Leu Gly Met Ala Val Val Val Thr Asn His Ile Thr 
            260                 265                 270         


Arg Asp Arg Asp Ser Gly Arg Leu Lys Pro Ala Leu Gly Arg Ser Trp 
        275                 280                 285             


Ser Phe Val Pro Ser Thr Arg Ile Leu Leu Asp Thr Ile Glu Gly Ala 
    290                 295                 300                 


Gly Ala Ser Gly Gly Arg Arg Met Ala Cys Leu Ala Lys Ser Ser Arg 
305                 310                 315                 320 


Gln Pro Thr Gly Phe Gln Glu Met Val Asp Ile Gly Thr Trp Gly Thr 
                325                 330                 335     


Ser Glu Gln Ser Ala Thr Leu Gln Gly Asp Gln Thr 
            340                 345             


<210>  47
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Ser Arg Asp His Asn Asn Pro Gln Glu Gly Pro Thr Ser Ser 
1               5                   10                  15      


Ser Gly Arg Arg Ala Ala Val Glu Asp Asn His Leu Leu Ile Lys Ala 
            20                  25                  30          


Val Gln Asn Glu Asp Val Asp Leu Val Gln Gln Leu Leu Glu Gly Gly 
        35                  40                  45              


Ala Asn Val Asn Phe Gln Glu Glu Glu Gly Gly Trp Thr Pro Leu His 
    50                  55                  60                  


Asn Ala Val Gln Met Ser Arg Glu Asp Ile Val Glu Leu Leu Leu Arg 
65                  70                  75                  80  


His Gly Ala Asp Pro Val Leu Arg Lys Lys Asn Gly Ala Thr Pro Phe 
                85                  90                  95      


Ile Leu Ala Ala Ile Ala Gly Ser Val Lys Leu Leu Lys Leu Phe Leu 
            100                 105                 110         


Ser Lys Gly Ala Asp Val Asn Glu Cys Asp Phe Tyr Gly Phe Thr Ala 
        115                 120                 125             


Phe Met Glu Ala Ala Val Tyr Gly Lys Val Lys Ala Leu Lys Phe Leu 
    130                 135                 140                 


Tyr Lys Arg Gly Ala Asn Val Asn Leu Arg Arg Lys Thr Lys Glu Asp 
145                 150                 155                 160 


Gln Glu Arg Leu Arg Lys Gly Gly Ala Thr Ala Leu Met Asp Ala Ala 
                165                 170                 175     


Glu Lys Gly His Val Glu Val Leu Lys Ile Leu Leu Asp Glu Met Gly 
            180                 185                 190         


Ala Asp Val Asn Ala Cys Asp Asn Met Gly Arg Asn Ala Leu Ile His 
        195                 200                 205             


Ala Leu Leu Ser Ser Asp Asp Ser Asp Val Glu Ala Ile Thr His Leu 
    210                 215                 220                 


Leu Leu Asp His Gly Ala Asp Val Asn Val Arg Gly Glu Arg Gly Lys 
225                 230                 235                 240 


Thr Pro Leu Ile Leu Ala Val Glu Lys Lys His Leu Gly Leu Val Gln 
                245                 250                 255     


Arg Leu Leu Glu Gln Glu His Ile Glu Ile Asn Asp Thr Asp Ser Asp 
            260                 265                 270         


Gly Lys Thr Ala Leu Leu Leu Ala Val Glu Leu Lys Leu Lys Lys Ile 
        275                 280                 285             


Ala Glu Leu Leu Cys Lys Arg Gly Ala Ser Thr Asp Cys Gly Asp Leu 
    290                 295                 300                 


Val Met Thr Ala Arg Arg Asn Tyr Asp His Ser Leu Val Lys Val Leu 
305                 310                 315                 320 


Leu Ser His Gly Ala Lys Glu Asp Phe His Pro Pro Ala Glu Asp Trp 
                325                 330                 335     


Lys Pro Gln Ser Ser His Trp Gly Ala Ala Leu Lys Asp Leu His Arg 
            340                 345                 350         


Ile Tyr Arg Pro Met Ile Gly Lys Leu Lys Phe Phe Ile Asp Glu Lys 
        355                 360                 365             


Tyr Lys Ile Ala Asp Thr Ser Glu Gly Gly Ile Tyr Leu Gly Phe Tyr 
    370                 375                 380                 


Glu Lys Gln Glu Val Ala Val Lys Thr Phe Cys Glu Gly Ser Pro Arg 
385                 390                 395                 400 


Ala Gln Arg Glu Val Ser Cys Leu Gln Ser Ser Arg Glu Asn Ser His 
                405                 410                 415     


Leu Val Thr Phe Tyr Gly Ser Glu Ser His Arg Gly His Leu Phe Val 
            420                 425                 430         


Cys Val Thr Leu Cys Glu Gln Thr Leu Glu Ala Cys Leu Asp Val His 
        435                 440                 445             


Arg Gly Glu Asp Val Glu Asn Glu Glu Asp Glu Phe Ala Arg Asn Val 
    450                 455                 460                 


Leu Ser Ser Ile Phe Lys Ala Val Gln Glu Leu His Leu Ser Cys Gly 
465                 470                 475                 480 


Tyr Thr His Gln Asp Leu Gln Pro Gln Asn Ile Leu Ile Asp Ser Lys 
                485                 490                 495     


Lys Ala Ala His Leu Ala Asp Phe Asp Lys Ser Ile Lys Trp Ala Gly 
            500                 505                 510         


Asp Pro Gln Glu Val Lys Arg Asp Leu Glu Asp Leu Gly Arg Leu Val 
        515                 520                 525             


Leu Tyr Val Val Lys Lys Gly Ser Ile Ser Phe Glu Asp Leu Lys Ala 
    530                 535                 540                 


Gln Ser Asn Glu Glu Val Val Gln Leu Ser Pro Asp Glu Glu Thr Lys 
545                 550                 555                 560 


Asp Leu Ile His Arg Leu Phe His Pro Gly Glu His Val Arg Asp Cys 
                565                 570                 575     


Leu Ser Asp Leu Leu Gly His Pro Phe Phe Trp Thr Trp Glu Ser Arg 
            580                 585                 590         


Tyr Arg Thr Leu Arg Asn Val Gly Asn Glu Ser Asp Ile Lys Thr Arg 
        595                 600                 605             


Lys Ser Glu Ser Glu Ile Leu Arg Leu Leu Gln Pro Gly Pro Ser Glu 
    610                 615                 620                 


His Ser Lys Ser Phe Asp Lys Trp Thr Thr Lys Ile Asn Glu Cys Val 
625                 630                 635                 640 


Met Lys Lys Met Asn Lys Phe Tyr Glu Lys Arg Gly Asn Phe Tyr Gln 
                645                 650                 655     


Asn Thr Val Gly Asp Leu Leu Lys Phe Ile Arg Asn Leu Gly Glu His 
            660                 665                 670         


Ile Asp Glu Glu Lys His Lys Lys Met Lys Leu Lys Ile Gly Asp Pro 
        675                 680                 685             


Ser Leu Tyr Phe Gln Lys Thr Phe Pro Asp Leu Val Ile Tyr Val Tyr 
    690                 695                 700                 


Thr Lys Leu Gln Asn Thr Glu Tyr Arg Lys His Phe Pro Gln Thr His 
705                 710                 715                 720 


Ser Pro Asn Lys Pro Gln Cys Asp Gly Ala Gly Gly Ala Ser Gly Leu 
                725                 730                 735     


Ala Ser Pro Gly Cys 
            740     


<210>  48
<211>  2179
<212>  DNA
<213>  Homo sapiens

<400>  48
acttctggag gtaaggcggt cgtcagccta tctcttctgc tggctgggct caatgccgcg       60

ggtgagcgtt cggccgaggc tgctcctacc cttgagtgat gtgccttgaa tgacgctgct      120

ttcatgcgct gctctcacgg ctgctttctc cgtcctcccc tgttactacc ttgggctgtt      180

tcagcgggcg ctcgcgttgg tcttcgaccc actttgcgtt tgttcacgtg tgctcccgac      240

acctagtgat gatgcgggtg tgctggttgg tgagacagga cagccggcac cagcgaatca      300

gacttccaca tttggaagca gttgtgattg ggcgtggccc agagaccaag atcactgata      360

agaaatgttc tcgacagcaa gtacagttga aagcagagtg taacaaggga tatgtcaagg      420

taaagcaggt aggagtcaat cccaccagca ttgactcagt cgtaattggg aaggaccaag      480

aggtgaagct gcagcctggc caggttctcc acatggtgaa tgaactttat ccatatattg      540

tagagtttga ggaagaggca aagaaccctg gcctggaaac acacaggaag agaaagagat      600

caggcaacag tgattctata gaaagggatg ctgctcagga agctgaggct gggacagggc      660

tggaacctgg gagcaactct ggccaatgct ctgtgcccct aaagaaggga aaagatgcac      720

ctatcaaaaa ggaatccctg ggccactgga gtcaaggctt gaagatttct atgcaggacc      780

ccaaaatgca ggtttacaaa gatgagcagg tggtggtgat aaaggataaa tacccaaagg      840

cccgttacca ttggctggtc ttaccgtgga cctccatttc cagtctgaag gctgtggcca      900

gggaacacct tgaactcctt aagcatatgc acactgtggg ggaaaaggtg attgtagatt      960

ttgctgggtc cagcaaactc cgcttccgat tgggctacca cgccattccg agtatgagcc     1020

atgtacatct tcatgtgatc agccaggatt ttgattctcc ttgccttaaa aacaaaaaac     1080

attggaattc tttcaataca gaatacttcc tagaatcaca agctgtgatc gagatggtac     1140

aagaggctgg tagagtaact gtccgagatg ggatgcctga gctcttgaag ctgccccttc     1200

gttgtcatga gtgccagcag ctgctgcctt ccattcctca gctgaaagaa catctcagga     1260

agcactggac acagtgattc tgcagagcct gagctgctgc tgtggtgtgg cccactggag     1320

caaactgctg gcacctattc tgggttgctt gtgaacttct actcatttcc taaattaaaa     1380

catgcagctt tttcacaaat ttattctatt attgagtggc cacaatgtag agtggctcaa     1440

agtacttcag gattaggaat ttgggtttgt catagatgta ttctctggtg agggtggctg     1500

ggatatacct gacccaccat cttcagaagg acccatgtca ggtctgacca ttgggagcaa     1560

agccatgttc acactgacct aatgcagagt atggaagcat tgggctggtt atacatttct     1620

gtttcttaga tttatcctcc gcctctgtag gcatggacaa cctttaatca gagcatctag     1680

agtggcctct tgtttatcct gaagatactg atgggtcttg ttttctgtta gtctgttttg     1740

taatattctt ttcccttcct tcatggggag gcttagtttg tccagtcctt ccatgccctt     1800

ctatcccaga ttacctaaat gttcccttct caggaattct gtctcatcag ttcttcacag     1860

tgagaaaaga ggctagatga tggtgtgggg ggttggagtt ttcttctaat accgagggtt     1920

cctggctgtg aggaaacagc cacatgttcg tcatgattga gctgtgaagt cttcttggac     1980

ctgttgtctg aaaataaagt taatttgttt gaggcatctc tcttaagtag gtggaaacta     2040

ttgaagttca gctaacaatc acagcatagg ttctgatgca tggaaaggtg gttggtgaat     2100

gaaaaagttg cgtagagcca ctactttctt tttccctgag aataaatttg gataaaacag     2160

ttgtattcaa aaaaaaaaa                                                  2179


<210>  49
<211>  7224
<212>  DNA
<213>  Homo sapiens

<400>  49
gtaccttgat ttcgtattct gagaggctgc tgcttagcgg tagccccttg gtttccgtgg       60

caacggaaaa gcgcgggaat tacagataaa ttaaaactgc gactgcgcgg cgtgagctcg      120

ctgagacttc ctggacgggg gacaggctgt ggggtttctc agataactgg gcccctgcgc      180

tcaggaggcc ttcaccctct gctctgggta aagttcattg gaacagaaag aaatggattt      240

atctgctctt cgcgttgaag aagtacaaaa tgtcattaat gctatgcaga aaatcttaga      300

gtgtcccatc tgtctggagt tgatcaagga acctgtctcc acaaagtgtg accacatatt      360

ttgcaaattt tgcatgctga aacttctcaa ccagaagaaa gggccttcac agtgtccttt      420

atgtaagaat gatataacca aaaggagcct acaagaaagt acgagattta gtcaacttgt      480

tgaagagcta ttgaaaatca tttgtgcttt tcagcttgac acaggtttgg agtatgcaaa      540

cagctataat tttgcaaaaa aggaaaataa ctctcctgaa catctaaaag atgaagtttc      600

tatcatccaa agtatgggct acagaaaccg tgccaaaaga cttctacaga gtgaacccga      660

aaatccttcc ttgcaggaaa ccagtctcag tgtccaactc tctaaccttg gaactgtgag      720

aactctgagg acaaagcagc ggatacaacc tcaaaagacg tctgtctaca ttgaattggg      780

atctgattct tctgaagata ccgttaataa ggcaacttat tgcagtgtgg gagatcaaga      840

attgttacaa atcacccctc aaggaaccag ggatgaaatc agtttggatt ctgcaaaaaa      900

ggctgcttgt gaattttctg agacggatgt aacaaatact gaacatcatc aacccagtaa      960

taatgatttg aacaccactg agaagcgtgc agctgagagg catccagaaa agtatcaggg     1020

tagttctgtt tcaaacttgc atgtggagcc atgtggcaca aatactcatg ccagctcatt     1080

acagcatgag aacagcagtt tattactcac taaagacaga atgaatgtag aaaaggctga     1140

attctgtaat aaaagcaaac agcctggctt agcaaggagc caacataaca gatgggctgg     1200

aagtaaggaa acatgtaatg ataggcggac tcccagcaca gaaaaaaagg tagatctgaa     1260

tgctgatccc ctgtgtgaga gaaaagaatg gaataagcag aaactgccat gctcagagaa     1320

tcctagagat actgaagatg ttccttggat aacactaaat agcagcattc agaaagttaa     1380

tgagtggttt tccagaagtg atgaactgtt aggttctgat gactcacatg atggggagtc     1440

tgaatcaaat gccaaagtag ctgatgtatt ggacgttcta aatgaggtag atgaatattc     1500

tggttcttca gagaaaatag acttactggc cagtgatcct catgaggctt taatatgtaa     1560

aagtgaaaga gttcactcca aatcagtaga gagtaatatt gaagacaaaa tatttgggaa     1620

aacctatcgg aagaaggcaa gcctccccaa cttaagccat gtaactgaaa atctaattat     1680

aggagcattt gttactgagc cacagataat acaagagcgt cccctcacaa ataaattaaa     1740

gcgtaaaagg agacctacat caggccttca tcctgaggat tttatcaaga aagcagattt     1800

ggcagttcaa aagactcctg aaatgataaa tcagggaact aaccaaacgg agcagaatgg     1860

tcaagtgatg aatattacta atagtggtca tgagaataaa acaaaaggtg attctattca     1920

gaatgagaaa aatcctaacc caatagaatc actcgaaaaa gaatctgctt tcaaaacgaa     1980

agctgaacct ataagcagca gtataagcaa tatggaactc gaattaaata tccacaattc     2040

aaaagcacct aaaaagaata ggctgaggag gaagtcttct accaggcata ttcatgcgct     2100

tgaactagta gtcagtagaa atctaagccc acctaattgt actgaattgc aaattgatag     2160

ttgttctagc agtgaagaga taaagaaaaa aaagtacaac caaatgccag tcaggcacag     2220

cagaaaccta caactcatgg aaggtaaaga acctgcaact ggagccaaga agagtaacaa     2280

gccaaatgaa cagacaagta aaagacatga cagcgatact ttcccagagc tgaagttaac     2340

aaatgcacct ggttctttta ctaagtgttc aaataccagt gaacttaaag aatttgtcaa     2400

tcctagcctt ccaagagaag aaaaagaaga gaaactagaa acagttaaag tgtctaataa     2460

tgctgaagac cccaaagatc tcatgttaag tggagaaagg gttttgcaaa ctgaaagatc     2520

tgtagagagt agcagtattt cattggtacc tggtactgat tatggcactc aggaaagtat     2580

ctcgttactg gaagttagca ctctagggaa ggcaaaaaca gaaccaaata aatgtgtgag     2640

tcagtgtgca gcatttgaaa accccaaggg actaattcat ggttgttcca aagataatag     2700

aaatgacaca gaaggcttta agtatccatt gggacatgaa gttaaccaca gtcgggaaac     2760

aagcatagaa atggaagaaa gtgaacttga tgctcagtat ttgcagaata cattcaaggt     2820

ttcaaagcgc cagtcatttg ctccgttttc aaatccagga aatgcagaag aggaatgtgc     2880

aacattctct gcccactctg ggtccttaaa gaaacaaagt ccaaaagtca cttttgaatg     2940

tgaacaaaag gaagaaaatc aaggaaagaa tgagtctaat atcaagcctg tacagacagt     3000

taatatcact gcaggctttc ctgtggttgg tcagaaagat aagccagttg ataatgccaa     3060

atgtagtatc aaaggaggct ctaggttttg tctatcatct cagttcagag gcaacgaaac     3120

tggactcatt actccaaata aacatggact tttacaaaac ccatatcgta taccaccact     3180

ttttcccatc aagtcatttg ttaaaactaa atgtaagaaa aatctgctag aggaaaactt     3240

tgaggaacat tcaatgtcac ctgaaagaga aatgggaaat gagaacattc caagtacagt     3300

gagcacaatt agccgtaata acattagaga aaatgttttt aaagaagcca gctcaagcaa     3360

tattaatgaa gtaggttcca gtactaatga agtgggctcc agtattaatg aaataggttc     3420

cagtgatgaa aacattcaag cagaactagg tagaaacaga gggccaaaat tgaatgctat     3480

gcttagatta ggggttttgc aacctgaggt ctataaacaa agtcttcctg gaagtaattg     3540

taagcatcct gaaataaaaa agcaagaata tgaagaagta gttcagactg ttaatacaga     3600

tttctctcca tatctgattt cagataactt agaacagcct atgggaagta gtcatgcatc     3660

tcaggtttgt tctgagacac ctgatgacct gttagatgat ggtgaaataa aggaagatac     3720

tagttttgct gaaaatgaca ttaaggaaag ttctgctgtt tttagcaaaa gcgtccagaa     3780

aggagagctt agcaggagtc ctagcccttt cacccataca catttggctc agggttaccg     3840

aagaggggcc aagaaattag agtcctcaga agagaactta tctagtgagg atgaagagct     3900

tccctgcttc caacacttgt tatttggtaa agtaaacaat ataccttctc agtctactag     3960

gcatagcacc gttgctaccg agtgtctgtc taagaacaca gaggagaatt tattatcatt     4020

gaagaatagc ttaaatgact gcagtaacca ggtaatattg gcaaaggcat ctcaggaaca     4080

tcaccttagt gaggaaacaa aatgttctgc tagcttgttt tcttcacagt gcagtgaatt     4140

ggaagacttg actgcaaata caaacaccca ggatcctttc ttgattggtt cttccaaaca     4200

aatgaggcat cagtctgaaa gccagggagt tggtctgagt gacaaggaat tggtttcaga     4260

tgatgaagaa agaggaacgg gcttggaaga aaataatcaa gaagagcaaa gcatggattc     4320

aaacttaggt gaagcagcat ctgggtgtga gagtgaaaca agcgtctctg aagactgctc     4380

agggctatcc tctcagagtg acattttaac cactcagcag agggatacca tgcaacataa     4440

cctgataaag ctccagcagg aaatggctga actagaagct gtgttagaac agcatgggag     4500

ccagccttct aacagctacc cttccatcat aagtgactct tctgcccttg aggacctgcg     4560

aaatccagaa caaagcacat cagaaaaagc agtattaact tcacagaaaa gtagtgaata     4620

ccctataagc cagaatccag aaggcctttc tgctgacaag tttgaggtgt ctgcagatag     4680

ttctaccagt aaaaataaag aaccaggagt ggaaaggtca tccccttcta aatgcccatc     4740

attagatgat aggtggtaca tgcacagttg ctctgggagt cttcagaata gaaactaccc     4800

atctcaagag gagctcatta aggttgttga tgtggaggag caacagctgg aagagtctgg     4860

gccacacgat ttgacggaaa catcttactt gccaaggcaa gatctagagg gaacccctta     4920

cctggaatct ggaatcagcc tcttctctga tgaccctgaa tctgatcctt ctgaagacag     4980

agccccagag tcagctcgtg ttggcaacat accatcttca acctctgcat tgaaagttcc     5040

ccaattgaaa gttgcagaat ctgcccagag tccagctgct gctcatacta ctgatactgc     5100

tgggtataat gcaatggaag aaagtgtgag cagggagaag ccagaattga cagcttcaac     5160

agaaagggtc aacaaaagaa tgtccatggt ggtgtctggc ctgaccccag aagaatttat     5220

gctcgtgtac aagtttgcca gaaaacacca catcacttta actaatctaa ttactgaaga     5280

gactactcat gttgttatga aaacagatgc tgagtttgtg tgtgaacgga cactgaaata     5340

ttttctagga attgcgggag gaaaatgggt agttagctat ttctgggtga cccagtctat     5400

taaagaaaga aaaatgctga atgagcatga ttttgaagtc agaggagatg tggtcaatgg     5460

aagaaaccac caaggtccaa agcgagcaag agaatcccag gacagaaaga tcttcagggg     5520

gctagaaatc tgttgctatg ggcccttcac caacatgccc acagatcaac tggaatggat     5580

ggtacagctg tgtggtgctt ctgtggtgaa ggagctttca tcattcaccc ttggcacagg     5640

tgtccaccca attgtggttg tgcagccaga tgcctggaca gaggacaatg gcttccatgc     5700

aattgggcag atgtgtgagg cacctgtggt gacccgagag tgggtgttgg acagtgtagc     5760

actctaccag tgccaggagc tggacaccta cctgataccc cagatccccc acagccacta     5820

ctgactgcag ccagccacag gtacagagcc acaggacccc aagaatgagc ttacaaagtg     5880

gcctttccag gccctgggag ctcctctcac tcttcagtcc ttctactgtc ctggctacta     5940

aatattttat gtacatcagc ctgaaaagga cttctggcta tgcaagggtc ccttaaagat     6000

tttctgcttg aagtctccct tggaaatctg ccatgagcac aaaattatgg taatttttca     6060

cctgagaaga ttttaaaacc atttaaacgc caccaattga gcaagatgct gattcattat     6120

ttatcagccc tattctttct attcaggctg ttgttggctt agggctggaa gcacagagtg     6180

gcttggcctc aagagaatag ctggtttccc taagtttact tctctaaaac cctgtgttca     6240

caaaggcaga gagtcagacc cttcaatgga aggagagtgc ttgggatcga ttatgtgact     6300

taaagtcaga atagtccttg ggcagttctc aaatgttgga gtggaacatt ggggaggaaa     6360

ttctgaggca ggtattagaa atgaaaagga aacttgaaac ctgggcatgg tggctcacgc     6420

ctgtaatccc agcactttgg gaggccaagg tgggcagatc actggaggtc aggagttcga     6480

aaccagcctg gccaacatgg tgaaacccca tctctactaa aaatacagaa attagccggt     6540

catggtggtg gacacctgta atcccagcta ctcaggtggc taaggcagga gaatcacttc     6600

agcccgggag gtggaggttg cagtgagcca agatcatacc acggcactcc agcctgggtg     6660

acagtgagac tgtggctcaa aaaaaaaaaa aaaaaaagga aaatgaaact agaagagatt     6720

tctaaaagtc tgagatatat ttgctagatt tctaaagaat gtgttctaaa acagcagaag     6780

attttcaaga accggtttcc aaagacagtc ttctaattcc tcattagtaa taagtaaaat     6840

gtttattgtt gtagctctgg tatataatcc attcctctta aaatataaga cctctggcat     6900

gaatatttca tatctataaa atgacagatc ccaccaggaa ggaagctgtt gctttctttg     6960

aggtgatttt tttcctttgc tccctgttgc tgaaaccata cagcttcata aataattttg     7020

cttgctgaag gaagaaaaag tgtttttcat aaacccatta tccaggactg tttatagctg     7080

ttggaaggac taggtcttcc ctagcccccc cagtgtgcaa gggcagtgaa gacttgattg     7140

tacaaaatac gttttgtaaa tgttgtgctg ttaacactgc aaataaactt ggtagcaaac     7200

acttccaaaa aaaaaaaaaa aaaa                                            7224


<210>  50
<211>  2402
<212>  DNA
<213>  Homo sapiens

<400>  50
gacgcgcgcg agatttgaat ttcctctgcg tgcggtcagt gcccgcgcag cgttgagttg       60

cacagcggta ttctcaccag gccctgcaat cggtgggcca cagtgccggc cacagagatg      120

gtggaaggac caggctgtac tctgaatgga gagaagattc gcgcgcgggt gctcccgggc      180

caggcggtga ccggcgtgcg gggaagcgct ctgcggagtc tgcagggccg cgccttgcgg      240

ctcgcagcct ccacggttgt ggtctccccg caggctgctg cactgaataa tgattccagc      300

cagaatgtct tgagcctgtt taatggatat gtttacagtg gcgtggaaac tttggggaag      360

gagctcttta tgtactttgg accaaaagct ttacggattc atttcggaat gaaaggcttc      420

atcatgatta atccacttga gtataaatat aaaaatggag cttctcctgt tttggaagtg      480

cagctcacca aagatttgat ttgtttcttt gactcatcag tagaactcag aaactcaatg      540

gaaagccaac agagaataag aatgatgaaa gaattagatg tatgttcacc tgaatttagt      600

ttcttgagag cagaaagtga agttaaaaaa cagaaaggcc ggatgctagg tgatgtgcta      660

atggatcaga acgtattgcc tggagtaggg aacatcatca aaaatgaagc tctctttgac      720

agtggtctcc acccagctgt taaagtttgt caattaacag atgaacagat ccatcacctc      780

atgaaaatga tacgtgattt cagcattctc ttttacaggt gccgtaaagc aggacttgct      840

ctctctaaac actataaggt ttacaagcgt cctaattgtg gtcagtgcca ctgcagaata      900

actgtgtgcc gctttgggga caataacaga atgacatatt tctgtcctca ctgtcaaaaa      960

gaaaatcctc aacatgttga catatgcaag ctaccgacta gaaatactat aatcagttgg     1020

acatctagca gggtggatca tgttatggac tccgtggctc ggaagtcgga agagcactgg     1080

acctgtgtgg tgtgtacttt aatcaataag ccctcttcta aggcatgtga tgcttgcttg     1140

acctcaaggc ctattgattc agtgctcaag agtgaagaaa attctactgt ctttagccac     1200

ttaatgaagt acccgtgtaa tacttttgga aaacctcata cagaagtcaa gatcaacaga     1260

aaaactgcat ttggaactac aactcttgtc ttgactgatt ttagcaataa atccagtact     1320

ttggaaagaa aaacaaagca aaaccagata ctagatgagg agtttcaaaa ctctcctcct     1380

gctagtgttt gtttgaatga tatacagcac ccctccaaga agacaacaaa cgatataact     1440

caaccatcca gcaaagtaaa catatcacct acaatcagtt cagaatctaa attatttagt     1500

ccagcacata aaaaaccgaa aacagcccaa tactcatcac cagagcttaa aagctgcaac     1560

cctggatatt ctaacagtga acttcaaatt aatatgacag atggccctcg taccttaaat     1620

cctgacagcc ctcgctgcag taaacacaac cgcctctgca ttctccgagt tgtgaggaag     1680

gatggggaaa acaagggcag gcagttttat gcctgtcctc tacctagaga agcacaatgt     1740

ggattttttg aatgggcaga tttgtccttc ccattctgca accatggcaa gcgttccacc     1800

atgaaaacag tattgaagat tggacctaac aatggaaaga atttttttgt gtgtcctctt     1860

gggaaggaaa aacaatgcaa ttttttccag tgggcagaaa atgggccagg aataaaaatt     1920

attcctggat gctaatatct gtagattctc tggcatttag tctcttcaaa ctgtgtataa     1980

tgtttggtcc tcctctgttt catagaaaag tcatagaata tctatgatac attgaaaagt     2040

tactgcaata tttgagaact gttctttttt tttcttgtgt gtgccatctt tccattgttg     2100

gctacgtctt ttcttttgcc ttgatgaacg ttctatgtat ttcatcggat atacagcata     2160

ttccatttag gatgtgtatt taatgcattt agtaatgacg ataaagtgtt tttagtatgc     2220

ttttagtctc ttgtaactgg ggagaagcag tgtttttttt ttaggaaagg attatgcgac     2280

acaataaaat aagatattct gtctgtagtg aatacatttc tcatgtacta acactattta     2340

taatatatga ttaaagatat ttcttgtttt attaaataat aagaaataag atctccttta     2400

tg                                                                    2402


<210>  51
<211>  4933
<212>  DNA
<213>  Homo sapiens

<400>  51
agcttcttgc caggcgcgta ggctcattct ccagtcagcg actgccgtcg tctctcgggc       60

aacagcgtcc tagagacgcc gaatgggcag cccctctgag accccgcggc ttggggtccg      120

cgcacgcggg tgccggccca gctaggcgga gaatcgagga ggggttcccg ggctcatcgc      180

agaggattgg aagggcctag attactgccc aatgacaaaa gtgtgggctt aatgtcctca      240

ctcttcaggg agagaatgtg gactttagca tttgaactga atatttgaga ttgaagattt      300

ctgaatagga tttaatgtgc aaaatggcga ttataccaga ctggcttagg tcgcatcctc      360

acacacgaaa atttacacat tcaagacccc attcttcacc gtgtagagta tattcaagga      420

atggttcccc aaataagttc agatcttctt caaccacagc tgttgcaaat ccaacactgt      480

cctccttaga tgttaaacgg attttatttc aaaaaattac cgacagaggg gatgagttgc      540

aaaaagcctt tcagctgctg gatactggtc agaacttgac tgtgtcaaaa agtgaactga      600

gaagaatcat cacagacttc ctgatgccgc tcacacgaga acagtttcag gacgtgttgg      660

ctcagatccc ccttagcacc tctggtactg taccgtacct tgcctttctg tccaggtttg      720

gtggaattga cctatatata aatggtataa agaggggagg tgggaatgaa atgaattgct      780

gccgcacatt aagagaactt gaaatccaag tgggagaaaa ggttttcaaa aacattaaga      840

ctgttatgaa agcctttgag ctcattgatg ttaacaagac tggactggtt cgaccgcagg      900

agctaagaag ggttctggag accttctgta tgaagttaag agacgaggaa tacgaaaagt      960

tttcgaaaca ctacaacatc cacaaggata ctgcagtaga ttacaacgtg tttttgaaga     1020

atctcagcat aaataacgac ttgaacctta gatattgtat gggaaatcaa gaggtctcgt     1080

tggagaatca acaagccaaa aattccaaaa aggaacgttt gctaggttct gcatcatctg     1140

aagatatctg gagaaactac tccttggatg aaattgagag gaacttttgt ctacaacttt     1200

cgaagtctta tgaaaaggtt gaaaaggccc tcagtgcagg ggacccctgt aaaggtggct     1260

acgtgtcttt taattatcta aagattgtcc tcgacacttt tgtataccaa ataccaagaa     1320

gaatttttat ccagttaatg aaaagatttg gacttaaagc caccactaaa atcaattgga     1380

agcaatttct aacatcattt catgagcctc aggggttgca agttagcagt aaaggtcccc     1440

tgacaaaaag aaatagcatc aactctagaa atgaatctca caaggaaaac atcatcacaa     1500

agttatttag acacactgaa gatcactctg cgtcactgaa gaaagcatta ctgataatca     1560

acactaaacc cgatggaccg ataacaagag aagaatttcg atatattcta aattgcatgg     1620

ctgtaaaact aagcgattca gaattcaaag aactaatgca aatgcttgac cctggggaca     1680

ctggagtggt caacaccagc atgtttattg atctgattga agagaactgt aggatgagaa     1740

agacatctcc ctgtacagat gctaagacac ctttcctcct ggcctgggat tcagtggaag     1800

aaattgttca tgatacaatt actaggaacc tacaagcttt ttataacatg ctacgctcat     1860

atgaccttgg agacacaggg cgcattggcc gaaataattt caagaaaatc atgcacgtct     1920

tctgtccatt tttaacgaat gcacatttca taaaactctg cagtaagatt caggacattg     1980

gttcaggaag aatcctttac aagaaacttt tggcatgcat aggaattgat ggcccaccca     2040

ctgtctctcc agttcttgtt ccaaaggatc agctgttaag tgaacattta caaaaagatg     2100

aacagcagca gccagatctt tctgagagaa ccaagctcac ggaggataaa accaccctga     2160

ccaagaagat gaccacagaa gaagtgattg aaaaattcaa aaagtgtata cagcagcagg     2220

acccggcatt caaaaaacga tttcttgact tcagcaagga gcctaatgga aaaattaacg     2280

tgcatgactt taagaaggta ctggaagaca ctgggatgcc catggacgat gatcagtatg     2340

ccctgctgac cactaaaata ggcttcgaga aggaagggat gagctatctt gattttgcag     2400

caggatttga agatcctcca atgagagggc cggaaaccac tccgccgcag cctccaactc     2460

cttcaaaaag ttacgtgaac agccacttta tcaccgcaga agaatgcctg aagcttttcc     2520

ctaggaggct gaaggagtca ttccgggacc cctactctgc cttctttaaa acagatgctg     2580

acagggatgg cataatcaac atgcatgacc ttcacagact gctcctgcat ctactgctta     2640

atctcaaaga cgacgagttt gagcgcttcc ttggccttct tggcttgaga cttagtgtca     2700

ctttaaattt tcgggaattt caaaatttgt gtgagaagag accatggaga acagatgaag     2760

cgcctcaaag actcattaga ccaaaacaga aggttgcgga ttcagaacta gcttgtgagc     2820

aggctcatca gtatcttgtt accaaagcaa aaaacagatg gtcagacttg tctaagaatt     2880

ttctagaaac cgataatgag ggcaatggca ttcttcgacg ccgggacata aagaacgcac     2940

tgtacggttt tgatattccc ctcacaccaa gagagtttga aaagctttgg gcaagatacg     3000

acaccgaggg aaaagggcac attacttacc aggaattttt acagaaattg ggtattaact     3060

attcgcctgc tgtccatcgg ccctgtgcag aggattattt caacttcatg ggtcatttta     3120

caaagccaca gcagctacag gaagagatga aggagctgca gcagagcaca gagaaggctg     3180

tggcagccag ggataagctt atggaccgcc atcaagatat cagcaaagca ttcaccaaaa     3240

ctgatcaatc caaaaccaac tacatatcca tatgcaagat gcaggaagtg ctggaagaat     3300

gtggatgttc tcttaccgaa ggggagctga cccatctgct aaacagttgg ggagtcagcc     3360

ggcatgataa tgctatcaat tacctcgact tcctgagagc agtggagaac agcaagtcaa     3420

caggagctca gcccaaggaa aaagaagaga gcatgccaat caattttgca acgctgaatc     3480

cacaggaggc tgtgaggaag atccaggaag tagttgagtc ctcccagctg gctttgtcca     3540

cggcattttc tgcattggat aaagaggata caggatttgt aaaggctaca gaattcggac     3600

aagttcttaa ggatttctgt tacaaactaa cggacaatca gtatcattat tttttgagga     3660

aactaagaat tcatctaacc ccctatataa attggaaata ttttctccag aactttagct     3720

gtttccttga ggagacagct gatgagtggg ctgagaaaat gcccaaaggc ccgccgccta     3780

cctctcccaa ggccacagcc gacagagaca tcctggctcg cctccacaaa gcagtgactt     3840

cccattacca tgccatcacc caggagtttg agaattttga caccatgaaa acgaacacca     3900

tctccagaga ggagtttagg gccatttgta atcgccgcgt ccaaatcctg acggacgaac     3960

agtttgacag actctggaac gagatgccag tcaatgccaa ggggaggctg aaatacccgg     4020

acttcctgag caggttcagt tccgagacag cagccacacc aatggccact ggtgactcgg     4080

ccgtggccca gagagggagc agtgtccctg acgtctcgga aggcaccaga tctgccctct     4140

cattgcccac tcaggagctg agaccagggt caaagtcgca gagccacccc tgtactccag     4200

cgagcaccac cgtgatcccg ggcactccac ccttgcagaa ctgtgatccc atagagagca     4260

ggctccggaa gagaatccag ggctgctggc gccagctcct gaaagaatgc aaggagaagg     4320

acgtggccag acagggggac atcaacgcct ccgatttcct ggctcttgtg gagaaattca     4380

acctggacat aagcaaagag gagtgtcagc agctcattat aaaatacgac ttaaagagca     4440

acgggaaatt tgcatactgt gacttcattc agagctgtgt cctcctgcta aaagcaaagg     4500

aaagctcact gatgcacagg atgaagatcc agaatgcaca caagatgaaa gaagccggcg     4560

cggagacgcc atctttttac tctgctctgc tgcgtattca gcccaaaatt gtgcactgct     4620

ggaggccaat gcggcgcacg ttcaaaagct atgatgaggc tggaacaggg ctgctaagcg     4680

tcgcagattt caggacggtc ctgagacagt acagcatcaa cctctctgag gaagagttct     4740

tccatattct ggagtattac gataagacgc tgtcttcaaa aatctcctac aacgacttcc     4800

tccgggcatt cctccagtag acacccctgc tgtgtgccca gcgggacgac agccacaggg     4860

cctgtttcaa ggctaataaa atcctataat ttgggggttt catgaatttt caaaaaaaac     4920

aaaactcaaa aaa                                                        4933


<210>  52
<211>  5160
<212>  DNA
<213>  Homo sapiens

<400>  52
aaaacccgga ggagcgggat ggcgcgcttt gactctggag tgggagtggg agcgagcgct       60

tctgcgactc cagttgtgag agccgcaagg gcatgggaat tgacgccact caccgacccc      120

cagtctcaat ctcaacgctg tgaggaaacc tcgactttgc caggtcccca agggcagcgg      180

ggctcggcga gcgaggcacc cttctccgtc cccatcccaa tccaagcgct cctggcactg      240

acgacgccaa gagactcgag tgggagttaa agcttccagt gagggcagca ggtgtccagg      300

ccgggcctgc gggttcctgt tgacgtcttg ccctaggcaa aggtcccagt tccttctcgg      360

agccggctgt cccgcgccac tggaaaccgc acctccccgc agcatgggca ccagcctcag      420

cccgaacgac ccttggccgc taaacccgct gtccatccag cagaccacgc tcctgctact      480

cctgtcggtg ctggccactg tgcatgtggg ccagcggctg ctgaggcaac ggaggcggca      540

gctccggtcc gcgcccccgg gcccgtttgc gtggccactg atcggaaacg cggcggcggt      600

gggccaggcg gctcacctct cgttcgctcg cctggcgcgg cgctacggcg acgttttcca      660

gatccgcctg ggcagctgcc ccatagtggt gctgaatggc gagcgcgcca tccaccaggc      720

cctggtgcag cagggctcgg ccttcgccga ccggccggcc ttcgcctcct tccgtgtggt      780

gtccggcggc cgcagcatgg ctttcggcca ctactcggag cactggaagg tgcagcggcg      840

cgcagcccac agcatgatgc gcaacttctt cacgcgccag ccgcgcagcc gccaagtcct      900

cgagggccac gtgctgagcg aggcgcgcga gctggtggcg ctgctggtgc gcggcagcgc      960

ggacggcgcc ttcctcgacc cgaggccgct gaccgtcgtg gccgtggcca acgtcatgag     1020

tgccgtgtgt ttcggctgcc gctacagcca cgacgacccc gagttccgtg agctgctcag     1080

ccacaacgaa gagttcgggc gcacggtggg cgcgggcagc ctggtggacg tgatgccctg     1140

gctgcagtac ttccccaacc cggtgcgcac cgttttccgc gaattcgagc agctcaaccg     1200

caacttcagc aacttcatcc tggacaagtt cttgaggcac tgcgaaagcc ttcggcccgg     1260

ggccgccccc cgcgacatga tggacgcctt tatcctctct gcggaaaaga aggcggccgg     1320

ggactcgcac ggtggtggcg cgcggctgga tttggagaac gtaccggcca ctatcactga     1380

catcttcggc gccagccagg acaccctgtc caccgcgctg cagtggctgc tcctcctctt     1440

caccaggtat cctgatgtgc agactcgagt gcaggcagaa ttggatcagg tcgtggggag     1500

ggaccgtctg ccttgtatgg gtgaccagcc caacctgccc tatgtcctgg ccttccttta     1560

tgaagccatg cgcttctcca gctttgtgcc tgtcactatt cctcatgcca ccactgccaa     1620

cacctctgtc ttgggctacc acattcccaa ggacactgtg gtttttgtca accagtggtc     1680

tgtgaatcat gacccactga agtggcctaa cccggagaac tttgatccag ctcgattctt     1740

ggacaaggat ggcctcatca acaaggacct gaccagcaga gtgatgattt tttcagtggg     1800

caaaaggcgg tgcattggcg aagaactttc taagatgcag ctttttctct tcatctccat     1860

cctggctcac cagtgcgatt tcagggccaa cccaaatgag cctgcgaaaa tgaatttcag     1920

ttatggtcta accattaaac ccaagtcatt taaagtcaat gtcactctca gagagtccat     1980

ggagctcctt gatagtgctg tccaaaattt acaagccaag gaaacttgcc aataagaagc     2040

aagaggcaag ctgaaatttt agaaatattc acatcttcgg agatgaggag taaaattcag     2100

tttttttcca gttcctcttt tgtgctgctt ctcaattagc gtttaaggtg agcataaatc     2160

aactgtccat caggtgaggt gtgctccata cccagcggtt cttcatgagt agtgggctat     2220

gcaggagctt ctgggagatt tttttgagtc aaagacttaa agggcccaat gaattattat     2280

atacatactg catcttggtt atttctgaag gtagcattct ttggagttaa aatgcacata     2340

tagacacata cacccaaaca cttacaccaa actactgaat gaagcagtat tttggtaacc     2400

aggccatttt tggtgggaat ccaagattgg tctcccatat gcagaaatag acaaaaagta     2460

tattaaacaa agtttcagag tatattgttg aagagacaga gacaagtaat ttcagtgtaa     2520

agtgtgtgat tgaaggtgat aagggaaaag ataaagacca gaaattccct tttcaccttt     2580

tcaggaaaat aacttagact ctagtattta tgggtggatt tatccttttg ccttctggta     2640

tacttcctta cttttaagga taaatcataa agtcagttgc tcaaaaagaa atcaatagtt     2700

gaattagtga gtatagtggg gttccatgag ttatcatgaa ttttaaagta tgcattatta     2760

aattgtaaaa ctccaaggtg atgttgtacc tcttttgctt gccaaagtac agaatttgaa     2820

ttatcagcaa agaaaaaaaa aaaagccagc caagctttaa attatgtgac cataatgtac     2880

tgatttcagt aagtctcata ggttaaaaaa aaaagtcacc aaatagtgtg aaatatatta     2940

cttaactgtc cgtaagcagt atattagtat tatcttgttc aggaaaaggt tgaataatat     3000

atgccttgta taatattgaa aattgaaaag tacaactaac gcaaccaagt gtgctaaaaa     3060

tgagcttgat taaatcaacc acctattttt gacatggaaa tgaagcaggg tttcttttct     3120

tcactcaaat tttggcgaat ctcaaaatta gatcctaaga tgtgttctta tttttataac     3180

atctttattg aaattctatt tataatacag aatcttgttt tgaaaataac ctaattaata     3240

tattaaaatt ccaaattcat ggcatgctta aattttaact aaattttaaa gccattctga     3300

ttattgagtt ccagttgaag ttagtggaaa tctgaacatt ctcctgtgga aggcagagaa     3360

atctaagctg tgtctgccca atgaataatg gaaaatgcca tgaattacct ggatgttctt     3420

tttacgaggt gacaagagtt ggggacagaa ctcccattac aactgaccaa gtttctcttc     3480

tagatgattt tttgaaagtt aacattaatg cctgcttttt ggaaagtcag aatcagaaga     3540

tagtcttgga agctgtttgg aaaagacagt ggagatgagg tcagttgtgt tttttaagat     3600

ggcaattact ttggtagctg ggaaagcata aagctcaaat gaaatgtatg cattcacatt     3660

tagaaaagtg aattgaagtt tcaagtttta aagttcattg caattaaact tccaaagaaa     3720

gttctacagt gtcctaagtg ctaagtgctt attacatttt attaagcttt ttggaatctt     3780

tgtaccaaaa ttttaaaaaa gggagttttt gatagttgtg tgtatgtgtg tgtggggtgg     3840

ggggatggta agagaaaaga gagaaacact gaaaagaagg aaagatggtt aaacattttc     3900

ccactcattc tgaattaatt aatttggagc acaaaattca aagcatggac atttagaaga     3960

aagatgtttg gcgtagcaga gttaaatctc aaataggcta ttaaaaaagt ctacaacata     4020

gcagatctgt tttgtggttt ggaatattaa aaaacttcat gtaattttat tttaaaattt     4080

catagctgta cttcttgaat ataaaaaatc atgccagtat ttttaaaggc attagagtca     4140

actacacaaa gcaggcttgc ccagtacatt taaatttttt ggcacttgcc attccaaaat     4200

attatgcccc accaaggctg agacagtgaa tttgggctgc tgtagcctat ttttttagat     4260

tgagaaatgt gtagctgcaa aaataatcat gaaccaatct ggatgcctca ttatgtcaac     4320

caggtccaga tgtgctataa tctgttttta cgtatgtagg cccagtcgtc atcagatgct     4380

tgcggcaaaa ggaaagctgt gtttatatgg aagaaagtaa ggtgcttgga gtttacctgg     4440

cttatttaat atgcttataa cctagttaaa gaaaggaaaa gaaaacaaaa aacgaatgaa     4500

aataactgaa tttggaggct ggagtaatca gattactgct ttaatcagaa accctcattg     4560

tgtttctacc ggagagagaa tgtatttgct gacaaccatt aaagtcagaa gttttactcc     4620

aggttattgc aataaagtat aatgtttatt aaatgcttca tttgtatgtc aaagctttga     4680

ctctataagc aaattgcttt tttccaaaac aaaaagatgt ctcaggtttg ttttgtgaat     4740

tttctaaaag ctttcatgtc ccagaactta gcctttacct gtgaagtgtt actacagcct     4800

taatattttc ctagtagatc tatattagat caaatagttg catagcagta tatgttaatt     4860

tgtgtgtttt tagctgtgac acaactgtgt gattaaaagg tatactttag tagacattta     4920

taactcaagg ataccttctt atttaatctt ttcttatttt tgtactttat catgaatgct     4980

tttagtgtgt gcataatagc tacagtgcat agttgtagac aaagtacatt ctggggaaac     5040

aacatttata tgtagccttt actgtttgat ataccaaatt aaaaaaaaat tgtatctcat     5100

tacttatact gggacaccat taccaaaata ataaaaatca ctttcataat cttgaaaaaa     5160


<210>  53
<211>  3859
<212>  DNA
<213>  Homo sapiens

<400>  53
ctaggcggcg gcggccgggt ccccaaggct gggcgctgct tgcggaaccg acggggcgga       60

gaggagcgtg gcgggaggag gagtaggaga agggggctgg tcaagggaag tgcgacgtgt      120

ctgcggagcc tttttatacc tccttcccgg gagtccggca gccgctgctg ctgctgctgc      180

tgctgctgcc gccgccgccg ccgccgtccc tgcgtccttc ggtctctgct cccgggaccc      240

gggctccgcc gcagccagcc agcatgtcgg ggatcaagaa gcaaaagacg gagaaccagc      300

agaaatccac caatgtagtc tatcaggccc accatgtgag caggaataag agagggcaag      360

tggttggaac aaggggtggg ttccgaggat gtaccgtgtg gctaacaggt ctctctggtg      420

ctggaaaaac aacgataagt tttgccctgg aggagtacct tgtctcccat gccatccctt      480

gttactccct ggatggggac aatgtccgtc atggccttaa cagaaatctc ggattctctc      540

ctggggacag agaggaaaat atccgccgga ttgctgaggt ggctaagctg tttgctgatg      600

ctggtctggt ctgcattacc agctttattt ctccattcgc aaaggatcgt gagaatgccc      660

gcaaaataca tgaatcagca gggctgccat tctttgaaat atttgtagat gcacctctaa      720

atatttgtga aagcagagac gtaaaaggcc tctataaaag ggccagagct ggggagatta      780

aaggatttac aggtattgat tctgattatg agaaacctga aactcctgag cgtgtgctta      840

aaaccaattt gtccacagtg agtgactgtg tccaccaggt agtggaactt ctgcaagagc      900

agaacattgt accctatact ataatcaaag atatccacga actctttgtg ccggaaaaca      960

aacttgacca cgtccgagct gaggctgaaa ctctcccttc attatcaatt actaagctgg     1020

atctccagtg ggtccaggtt ttgagcgaag gctgggccac tcccctcaaa ggtttcatgc     1080

gggagaagga gtacttacag gttatgcact ttgacaccct gctagatgat ggcgtgatca     1140

acatgagcat ccccattgta ctgcccgtct ctgcagagga taagacacgg ctggaagggt     1200

gcagcaagtt tgtcctggca catggtggac ggagggtagc tatcttacga gacgctgaat     1260

tctatgaaca cagaaaagag gaacgctgtt cccgtgtttg ggggacaaca tgtacaaaac     1320

acccccatat caaaatggtg atggaaagtg gggactggct ggttggtgga gaccttcagg     1380

tgctggagaa aataagatgg aatgatgggc tggaccaata ccgtctgaca cctctggagc     1440

tcaaacagaa atgtaaagaa atgaatgctg atgcggtgtt tgcattccag ttgcgcaatc     1500

ctgtccacaa tggccatgcc ctgttgatgc aggacactcg ccgcaggctc ctagagaggg     1560

gctacaagca cccggtcctc ctactacacc ctctgggcgg ctggaccaag gatgacgatg     1620

tgcctctaga ctggcggatg aagcagcacg cggctgtgct cgaggaaggg gtcctggatc     1680

ccaagtcaac cattgttgcc atctttccgt ctcccatgtt atatgctggc cccacagagg     1740

tccagtggca ctgcaggtcc cggatgattg cgggtgccaa tttctacatt gtggggaggg     1800

accctgcagg aatgccccat cctgaaacca agaaggatct gtatgaaccc actcatgggg     1860

gcaaggtctt gagcatggcc cctggcctca cctctgtgga aatcattcca ttccgagtgg     1920

ctgcctacaa caaagccaaa aaagccatgg acttctatga tccagcaagg cacaatgagt     1980

ttgacttcat ctcaggaact cgaatgagga agctcgcccg ggaaggagag aatcccccag     2040

atggcttcat ggcccccaaa gcatggaagg tcctgacaga ttattacagg tccctggaga     2100

agaactaagc ctttggctcc agagtttctt tctgaagtgc tctttgatta ccttttctat     2160

ttttatgatt agatgctttg tattaaattg cttctcaatg atgcatttta atcttttata     2220

atgaagtaaa agttgtgtct ataattaaaa aaaaatatat atatatacac acacacatat     2280

acatacaaag tcaaactgaa gaccaaatct tagcaggtaa aagcaatatt cttatacatt     2340

tcataataaa attagctcta tgtattttct actgcacctg agcaggcagg tcccagattt     2400

cttaaggctt tgtttgacca tgtgtctagt tacttgctga aaagtgaata tattttccag     2460

catgtcttga caacctgtac tcttccaatg tcatttatca gttgtaaaat atatcagatt     2520

gtgtcctctt ctgtacaatt gacaaaaaaa aaaatttttt tttctcactc taaaagaggt     2580

gtggctcaca tcaagattct tcctgatatt ttacctcatg ctgtacaaag ccttaatgtt     2640

gtaatcatat cttacgtgtt gaagacctga ctggagaaac aaaatgtgca ataacgtgaa     2700

ttttatctta gagatctgtg cagcctattt ctgtcacaaa agttatattg tctaataaga     2760

gaagtcttaa tggcctctgt gaataatgta actccagtta cacggtgact tttaatagca     2820

tacagtgatt tgatgaaagg acgtcaaaca atgtggcgat gtcgtggaaa gttatctttc     2880

ccgctctttg ctgtggtcat tgtgtcttgc agaaaggatg gccctgatgc agcagcagcg     2940

ccagctgtaa taaaaaataa ttcacactat cagactagca aggcactaga actggaaaag     3000

accacagaaa acaaagaatc caaccctttc atcttacagg tgaacaaact gtgatgatgc     3060

acatgtatgt gttttgtaag ctgtgagcac cgtaacaaaa tgtaaatttg ccattattag     3120

gaagtgctgg tggcagtgaa gaagcaccca ggccacttga ctcccagtct ggtgccctgt     3180

ctacaccaga caacacagga gctgggtcag attcccctca gctgcttaac aaagttcctc     3240

gaacagaaag tgcttacaaa gctgccttct cggatactga aaggtcgagt tttctgaact     3300

gcactgattt tattgcagtt gaaaaaaaaa aaaagctatt ccaaagattt caagctgttc     3360

tgagacatct tctgatggct ttacttcctg agaggcaatg tttttacttt atgcataatt     3420

cattgttgcc aaggaataaa gtgaagaaac agcacctttt aatatatagg tctctctgga     3480

agagacctaa attagaaaga gaaaactgtg acaattttca tattctcatt cttaaaaaac     3540

actaatctta actaacaaaa gttcttttga gaataagtta cacacaatgg ccacagcagt     3600

ttgtctttaa tagtatagtg cctatactca tgtaatcggt tactcactac tgcctttaaa     3660

aaaaaaaacc agcatattta ttgaaaacat gagacaggat tatagtgcct taaccgatat     3720

attttgtgac ttaaaaaata catttaaaac tgctcttctg ctctagtacc atgcttagtg     3780

caaatgatta tttctatgta caactgatgc ttgttcttat tttaataaat ttatcagagt     3840

gaaaaaaaaa aaaaaaaaa                                                  3859


<210>  54
<211>  8626
<212>  DNA
<213>  Homo sapiens

<400>  54
acgacggggg aggtgctgta cgtccaagat ggcggcgccc tgtaggctgg agggactgtg       60

aggtaaacag ctgaggggga ggagacggtg gtgaccatga aagacaccag gttgacagca      120

ctggaaactg aagtaccagt tgtcgctaga acagtttggt agtggcccca atgaagaacc      180

ttcagaacct gtagcacacg tcctggagcc agcacagcgc cttcgagcga gagaatggcc      240

caacaagcaa atgtcgggga gcttcttgcc atgctggact cccccatgct gggtgtgcgg      300

gacgacgtga cagctgtctt taaagagaac ctcaattctg accgtggccc tatgcttgta      360

aacaccttgg tggattatta cctggaaacc agctctcagc cggcattgca catcctgacc      420

accttgcaag agccacatga caagcacctc ttggacagga ttaacgaata tgtgggcaaa      480

gccgccactc gtttatccat cctctcgtta ctgggtcatg tcataagact gcagccatct      540

tggaagcata agctctctca agcacctctt ttgccttctt tactaaaatg tctcaagatg      600

gacactgacg tcgttgtcct cacaacaggc gtcttggtgt tgataaccat gctaccaatg      660

attccacagt ctgggaaaca gcatcttctt gatttctttg acatttttgg ccgtctgtca      720

tcatggtgcc tgaagaaacc aggccacgtg gcggaagtct atctcgtcca tctccatgcc      780

agtgtgtacg cactctttca tcgcctttat ggaatgtacc cttgcaactt cgtctccttt      840

ttgcgttctc attacagtat gaaagaaaac ctggagactt ttgaagaagt ggtcaagcca      900

atgatggagc atgtgcgaat tcatccggaa ttagtgactg gatccaagga ccatgaactg      960

gaccctcgaa ggtggaagag attagaaact catgatgttg tgatcgagtg tgccaaaatc     1020

tctctggatc ccacagaagc ctcatatgaa gatggctatt ctgtgtctca ccaaatctca     1080

gcccgctttc ctcatcgttc agccgatgtc accaccagcc cttatgctga cacacagaat     1140

agctatgggt gtgctacttc taccccttac tccacgtctc ggctgatgtt gttaaatatg     1200

ccagggcagc tacctcagac tctgagttcc ccatcgacac ggctgataac tgaaccacca     1260

caagctactc tttggagccc atctatggtt tgtggtatga ccactcctcc aacttctcct     1320

ggaaatgtcc cacctgatct gtcacaccct tacagtaaag tctttggtac aactgcaggt     1380

ggaaaaggaa ctcctctggg aaccccagca acctctcctc ctccagcccc actctgtcat     1440

tcggatgact acgtgcacat ttcactcccc caggccacag tcacaccccc caggaaggaa     1500

gagagaatgg attctgcaag accatgtcta cacagacaac accatcttct gaatgacaga     1560

ggatcagaag agccacctgg cagcaaaggt tctgtcactc taagtgatct tccagggttt     1620

ttaggtgatc tggcctctga agaagatagt attgaaaaag ataaagaaga agctgcaata     1680

tctagagaac tttctgagat caccacagca gaggcagagc ctgtggttcc tcgaggaggc     1740

tttgactctc ccttttaccg agacagtctc ccaggttctc agcggaagac ccactcggca     1800

gcctccagtt ctcagggcgc cagcgtgaac cctgagcctt tacactcctc cctggacaag     1860

cttgggcctg acacaccaaa gcaagccttt actcccatag acctgccctg cggcagtgct     1920

gatgaaagcc ctgcgggaga cagggaatgc cagacttctt tggagaccag tatcttcact     1980

cccagtcctt gtaaaattcc acctccgacg agagtgggct ttggaagcgg gcagcctccc     2040

ccgtatgatc atctttttga ggtggcattg ccaaagacag cccatcattt tgtcatcagg     2100

aagactgagg agctgttaaa gaaagcaaaa ggaaacacag aggaagatgg tgtgccctct     2160

acctccccaa tggaagtgct ggacagactg atacagcagg gagcagacgc gcacagcaag     2220

gagctgaaca agttgccttt acccagcaag tctgtcgact ggacccactt tggaggctct     2280

cctccttcag atgagatccg caccctccga gaccagttgc ttttactgca caaccagtta     2340

ctctatgagc gttttaagag gcagcagcat gccctccgga acaggcggct cctccgcaag     2400

gtgatcaaag cagcagctct ggaggaacat aatgctgcca tgaaagatca gttgaagtta     2460

caagagaagg acatccagat gtggaaggtt agtctgcaga aagaacaagc tagatacaat     2520

cagctccagg agcagcgtga cactatggta accaagctcc acagccagat cagacagctg     2580

cagcatgacc gagaggaatt ctacaaccag agccaggaat tacagacgaa gctggaggac     2640

tgcaggaaca tgattgcgga gctgcggata gaactgaaga aggccaacaa caaggtgtgt     2700

cacactgagc tgctgctcag tcaggtttcc caaaagctct caaacagtga gtcggtccag     2760

cagcagatgg agttcttgaa caggcagctg ttggttcttg gggaggtcaa cgagctctat     2820

ttggaacaac tgcagaacaa gcactcagat accacaaagg aagtagaaat gatgaaagcc     2880

gcctatcgga aagagctaga aaaaaacaga agccatgttc tccagcagac tcagaggctt     2940

gatacctccc aaaaacggat tttggaactg gaatctcacc tggccaagaa agaccacctt     3000

cttttggaac agaagaaata tctagaggat gtcaaactcc aggcaagagg acagctgcag     3060

gccgcagaga gcaggtatga ggctcagaaa aggataaccc aggtgtttga attggagatc     3120

ttagatttat atggcaggtt ggagaaagat ggcctcctga aaaaacttga agaagaaaaa     3180

gcagaagcag ctgaagcagc agaagaaagg cttgactgtt gtaatgacgg gtgctcagat     3240

tccatggtag ggcacaatga agaggcatct ggccacaacg gtgagaccaa gacccccagg     3300

cccagcagcg cccggggcag tagtggaagc agaggtggtg gaggcagcag cagcagcagc     3360

agcgagcttt ctaccccaga gaaaccccca caccagaggg caggcccatt cagcagtcgg     3420

tgggagacga ctatgggaga agcgtctgcc agcatcccca ccactgtggg ctcacttccc     3480

agttcaaaaa gcttcctggg tatgaaggct cgagagttat ttcgtaataa gagcgagagc     3540

cagtgtgatg aggacggcat gaccagtagc ctttctgaga gcctaaagac agaactgggc     3600

aaagacttgg gtgtggaagc caagattccc ctgaacctag atggccctca cccgtctccc     3660

ccgaccccgg acagtgttgg acagctacat atcatggact acaatgagac tcatcatgaa     3720

cacagctaag gaatgatggt caatcagtgt taacttgcat attgttggca cagaacagga     3780

ggtgtgaatg cacgtttcaa agctttcctg tttccagggt ctgagtgcaa gttcatgtgt     3840

ggaaatggga cggaggtcct ttggacagct gactgaatgc agaacggttt ttggatctgg     3900

cattgaaatg cctcttgacc ttcccctcca cccgccctaa ccccctctca tttacctcgc     3960

agtgtgttct aatccaaggg ccagttggtg ttcctcagta gctttacttt cttcctttcc     4020

cccccaaatg gttgcgtcct ttgaacctgt gcaatatgag gccaaattta atctttgagt     4080

ctaacacacc actttctgct ttcccgaagt tcagataact gggttggctc tcaattagac     4140

caggtagttt gttgcattgc aggtaagtct ggttttgtcc cttccaggag gacatagcct     4200

gcaaagctgg ttgtctttac atgaaagcgt ttacatgaga ctttccgact gcttttttga     4260

ttctgaagtt cagcatctaa agcagcaggt ctagaagaac aacggtttat tcatacttgc     4320

attcttttgg cagttctgat aagcttccta gaaagttctg tgtaaacaga agcctgtttc     4380

agaaatctgg agctggcact gtggagacca cacacccttt gggaaagctc ttgtctcttc     4440

ttcccccact acctcttatt tatttggtgt ttgcttgaat gctggtacta ttgtgaccac     4500

aggctggtgt gtaggtggta aaacctgttc tccataggag ggaaggagca gtcactggga     4560

gaggttaccc gagaagcact tgagcatgag gaactgcacc tttaggccat ctcagcttgc     4620

tgggcctttt gttaaaccct tctgtctact ggcctccctt tgtgtgcata cgcctcttgt     4680

tcatgtcagc ttatatgtga cactgcagca gaaaggctct gaaggtccaa agagtttctg     4740

caaagtgtat gtgaccatca tttcccaggc cattagggtt gcctcactgt agcaggttct     4800

aggctaccag aagaggggca gctttttcat accaattcca actttcaggg gctgactctc     4860

cagggagctg atgtcatcac actctccatg ttagtaatgg cagagcagtc taaacagagt     4920

ccgggagaat gctggcaaag gctggctgtg tatacccact aggctgcccc acgtgctccc     4980

gagagatgac actagtcaga aaattggcag tggcagagaa tccaaactca acaagtgctc     5040

ctgaaagaaa cgctagaagc ctaagaactg tggtctggtg ttccagctga ggcaggggga     5100

tttggtagga aggagccagt gaacttggct ttcctgtttc tatctttcat taaaaagaat     5160

agaaggattc agtcataaag aggtaaaaaa ctgtcacggt acgaaatctt agtgcccacg     5220

gaggcctcga gcagagagaa tgaaagtctt tttttttttt tttttttttt agcatggcaa     5280

taaatattct agcatcccta actaaagggg actagacagt tagagactct gtcaccctag     5340

ctataccagc agaaaacctg ttcaggcagg ctttctgggt gtgactgatt cccagcctgt     5400

ggcagggcgt ggtcccaact actcagccta gcacaggctg gcagttggta ctgaattgtc     5460

agatgtggag tattagtgac accacacatt taattcagct ttgtccaaag gaaagcttaa     5520

aacccaatac agtctagttt cctggttccg ttttagaaaa ggaaaacgtg aacaaactta     5580

gaaagggaag gaaatcccat cagtgaatcc tgaaactggt tttaagtgct ttccttctcc     5640

tcatgcccaa gagatctgtg ccatagaaca agataccagg cacttaaagc cttttcctga     5700

attggaaagg aaaagaggcc caagtgcaaa agaaaaaaca ttttagaaac ggacagctta     5760

taaaaataaa gggaagaaag gaggcagcat ggagagaggc ctgtgctaga agctccatgg     5820

acgtgtctgc acagggtcct cagctcatcc atgcggcctg ggtgtccttt tactcagctt     5880

tataacaaat gtggctccaa gctcaggtgc ctttgagttc taggaggctg tgggttttat     5940

tcaactacgg ttgggagaat gagacctgga gtcatgttga aggtgcccaa cctaaaaatg     6000

taggctttca tgttgcaaag aactccagag tcagtagtta ggtttggttt ggttttggac     6060

atgataaacc tgccaagagt caacaggtca cttgatcatg ctgcagtggg tagttctaag     6120

gatggaaagg tgacagtatt actctcgaga ggcaattcag tcctgggcaa aggtattagt     6180

acaataagcg ttaagggcag agtctacctt gaaaccaatt aagcagcttg gtattcataa     6240

atattgggat tggatggcct ccatccagaa atcactatgg gtgagcatac ctgtctcagc     6300

tgtttggcca atgtgcataa cctactcgga tccccacctg acactaacca gagtcagcac     6360

aggccccgag gagcccgaag tctgctgctg tgcagcatgg aattccttta aaaaggtgca     6420

ctacagtttt agcggggagg gggataggaa gacgcagagc aaatgagctc cggagtccct     6480

gcaggtgaat aaacacacag atctgcatct gatagaactt tgatggattt tcaaaaagcc     6540

gttgacaagg ctctgctata cagtctataa aaattgttat tatgggattg gaagaaacac     6600

gtggtcatga atagaaaaaa aacaaaccca aaggtaggaa ggtcaaggtc atttcttaga     6660

tggagaagtt gtgaaagatg tccttggaga tgagttttag gaccagcatt actaaggcag     6720

gtgggcagac agtgacctct ctaggtgtgt ccacagagtt tttcaggaga gaaaactgcc     6780

tgacctttgg gactaagctg cggaatcttc ttactaagct tgaagagtgg agaggcgaga     6840

ggtgagctac tttgtgagcc aaagcttatg tgacatggtt ggggaaacag tccaaactgt     6900

tctgagaagg tgaactgtta cgacccagga caattagaaa aattcaccca ccatgccgca     6960

cattactggg taaaagcagg gcagcaggga acaaaactcc agactcttgg gccgtcccca     7020

tttgcaacag cacacatagt ttctggtata tttgttggga aagataaaac tctagcagtt     7080

gttgagggga ggatgtataa aatggtcatg gggatgaaag gatctctgag accacagagg     7140

ctcagactca ctgttaagaa tagaaaactg ggtatgcgtt tcatgtagcc agcagaactg     7200

aagtgtgctg tgacaagcca atgtgaattt ctaccaaata gtagagcata ccacttgaag     7260

aaggaaagaa ccgaagagca aacaaaagtt ctgcgtaatg agactcacct tttctcgctg     7320

aaagcactaa gaggtgggag gaggcctgca caggctggag gagggtttgg gcagagcgaa     7380

gacccggcca ggaccttggt gagatggggt gccgcccacc tcctgcggat actcttggag     7440

agttgttccc ccagggggct ctgccccacc tggagaagga agctgcctgg tgtggagtga     7500

ctcaaatcag tatacctatc tgctgcacct tcactctcca gggtacatgc tttaaaaccg     7560

acccgcaaca agtattggaa aaatgtatcc agtctgaaga tgtttgtgta tctgtttaca     7620

tccagagttc tgtgacacat gccccccaga ttgctgcaaa gatcccaagg cattgattgc     7680

acttgattaa gcttttgtct gtaggtgaaa gaacaagttt aggtcgagga ctggccccta     7740

ggctgctgct gtgacccttg tcccatgtgg cttgtttgcc tgtccgggac tcttcgatgt     7800

gcccagggga gcgtgttcct gtctcttcca tgccgtcctg cagtccttat ctgctcgcct     7860

gagggaagag tagctgtagc tacaagggaa gcctgcctgg aagagccgag cacctgtgcc     7920

catggcttct ggtcatgaaa cgagttaatg atggcagagg agcttcctcc ccacttcgca     7980

gcgccacatt atccatcctc tgagataagt aggctggttt aaccattgga atggaccttt     8040

cagtggaaac cctgagagtc tgagaacccc cagaccaacc cttccctccc tttccccacc     8100

tcttacagtg tttggacagg agggtatggt gctgctctgt gtagcaagta ctttggctta     8160

tgaaagaggc agccacgcat tttgcactag gaagaatcag taatcacttt tcagaagact     8220

tctatggacc acaaatatat tacggaggaa cagattttgc taagacataa tctagtttta     8280

taactcaatc atgaatgaac catgtgtggc aaacttgcag tttaaagggg tcccatcagt     8340

gaaagaaact gatttttttt aacggactgc ttttagttaa attgaagaaa gtcagctctt     8400

gtcaaaaggt ctaaactttc ccgcctcaat cctaaaagca tgtcaacaat ccacatcaga     8460

tgccataaat atgaactgca ggataaaatg gtacaatctt agtgaatggg aattggaatc     8520

aaaagagttt gctgtccttc ttagaatgtt ctaaaatgtc aaggcagttg cttgtgttta     8580

actgtgaaca aataaaaatt tattgttttg cactacaaaa aaaaaa                    8626


<210>  55
<211>  760
<212>  DNA
<213>  Homo sapiens

<400>  55
gattgtggct caccctccat cactcccagg ggcccctggc ccagcagccg cagctcccaa       60

ccacaatatc ctttggggtt tggcctacgg agctggggcg gatgaccccc aaatagccct      120

ggcagattcc ccctagaccc gcccgcacca tggtcaggca tgcccctcct catcgctggg      180

cacagcccag agggtataaa cagtgctgga ggctggcggg gcaggccagc tgagtcctga      240

gcagcagccc agcgcagcca ccgagacacc atgagagccc tcacactcct cgccctattg      300

gccctggccg cactttgcat cgctggccag gcaggtgcga agcccagcgg tgcagagtcc      360

agcaaaggtg cagcctttgt gtccaagcag gagggcagcg aggtagtgaa gagacccagg      420

cgctacctgt atcaatggct gggagcccca gtcccctacc cggatcccct ggagcccagg      480

agggaggtgt gtgagctcaa tccggactgt gacgagttgg ctgaccacat cggctttcag      540

gaggcctatc ggcgcttcta cggcccggtc tagggtgtcg ctctgctggc ctggccggca      600

accccagttc tgctcctctc caggcaccct tctttcctct tccccttgcc cttgccctga      660

cctcccagcc ctatggatgt ggggtcccca tcatcccagc tgctcccaaa taaactccag      720

aagaggaatc tgtgggcctg tgaaaaaaaa aaaaaaaaaa                            760


<210>  56
<211>  1738
<212>  DNA
<213>  Homo sapiens

<400>  56
agcggactgc gcatgtgcag gacccagcag gtctagagct tttctgtgtt tctccggact       60

tcgagccatg gcggtgacgg aagcgagcct gttgcgccag tgccccctgc ttctgcccca      120

gaaccggtcg aaaaccgtgt atgagggatt catctcggct cagggaagag acttccacct      180

taggatagtg ttgcctgaag atttacaact gaagaatgca agattattat gtagttggca      240

gctgagaaca atacttagtg gataccatcg aatagtacaa cagagaatgc agcactctcc      300

tgatctaatg agctttatga tggagttgaa gatgcttttg gaagttgcct taaagaatag      360

acaagagctg tatgcactac ctcctcctcc ccagttctac tcaagcctta ttgaagagat      420

aggaactctt ggttgggata aacttgtgta tgcggatacc tgcttcagta ccatcaagtt      480

aaaagcagaa gatgcttctg gtagagagca tttaatcact ctcaagttga aggcaaagta      540

tcctgcagaa tcaccagatt attttgtgga ttttcctgtt ccattttgtg cctcctggac      600

acctcagagc tccttaataa gcatttatag tcagtttttg gcagcaatag aatcactaaa      660

ggcattctgg gatgttatgg atgaaatcga tgagaagacc tgggtacttg agccagaaaa      720

acctccacgg agtgcaacag cacgcagaat tgcattaggt aataatgttt ccataaatat      780

agaggtagac cccaggcatc ctactatgct tcctgagtgc ttctttcttg gagctgacca      840

tgtggtaaaa cccctgggaa ttaagctgag caggaacata catttgtggg atccagaaaa      900

tagtgtgtta caaaatttga aagatgtttt agaaattgat tttccagctc gtgctatcct      960

ggaaaaatct gattttacta tggattgtgg aatttgttat gcttatcaac ttgacggtac     1020

cattcctgat caagtgtgtg ataattctca gtgtggacaa cctttccatc aaatatgctt     1080

atatgagtgg ctgagaggac tactaactag tagacagagt tttaacatca tatttggtga     1140

atgtccatat tgtagtaagc caattacctt aaaaatgtct ggaaggaaac actgaaataa     1200

gaatacaaca tttcggtgaa gagctggaaa cttaaaaaat tatcaaaagg aattttggta     1260

tcatcttcag agaaaaaata aagcaagaaa tactaacatc aaaaggacag gtatgatgat     1320

gcgataataa taaacatctg cgtttgtctc ttcactaaga gtaaactggg aaattgtagg     1380

ccaaagtcca gttgaacttt ctaagtctgt gatccccgtg ctgactgtgg aagtgtattt     1440

ataccaagat ggagatcttg acttcttgaa tatatctgga ctggtaaaat cttgatgagg     1500

ctcataaaat gagtttggga attgtgtata gctgattttt tgtgggaaac tgtttacttc     1560

attcaaaggt tcttgagact cttgatattt ctgtcttctc cttgtgcttt cctatggaaa     1620

aaatacatat atagtttagt ttgttagacg tgagttatcc aagtatttat tttgtgtagt     1680

gtgtaagaat gctaaataaa atgttataca agatcaaaaa aaaaaaaaaa aaaaaaaa       1738


<210>  57
<211>  4472
<212>  DNA
<213>  Homo sapiens

<400>  57
ccgcagacgc ctgggaactg cggccgcggg ctcgcgctcc tcgccaggcc ctgccgccgg       60

gctgccatcc ttgccctgcc atgtctcgcc ggaagcctgc gtcgggcggc ctcgctgcct      120

ccagctcagc ccctgcgagg caagcggttt tgagccgatt cttccagtct acgggaagcc      180

tgaaatccac ctcctcctcc acaggtgcag ccgaccaggt ggaccctggc gctgcagcgg      240

ctgcagcggc cgcagcggcc gcagcgcccc cagcgccccc agctcccgcc ttcccgcccc      300

agctgccgcc gcacatagct acagaaattg acagaagaaa gaagagacca ttggaaaatg      360

atgggcctgt taaaaagaaa gtaaagaaag tccaacaaaa ggaaggagga agtgatctgg      420

gaatgtctgg caactctgag ccaaagaaat gtctgaggac caggaatgtt tcaaagtctc      480

tggaaaaatt gaaagaattc tgctgcgatt ctgcccttcc tcaaagtaga gtccagacag      540

aatctctgca ggagagattt gcagttctgc caaaatgtac tgattttgat gatatcagtc      600

ttctacacgc aaagaatgca gtttcttctg aagattcgaa acgtcaaatt aatcaaaagg      660

acacaacact ttttgatctc agtcagtttg gatcatcaaa tacaagtcat gaaaatttac      720

agaaaactgc ttccaaatca gctaacaaac ggtccaaaag catctatacg ccgctagaat      780

tacaatacat agaaatgaag cagcagcaca aagatgcagt tttgtgtgtg gaatgtggat      840

ataagtatag attctttggg gaagatgcag agattgcagc ccgagagctc aatatttatt      900

gccatttaga tcacaacttt atgacagcaa gtatacctac tcacagactg tttgttcatg      960

tacgccgcct ggtggcaaaa ggatataagg tgggagttgt gaagcaaact gaaactgcag     1020

cattaaaggc cattggagac aacagaagtt cactcttttc ccggaaattg actgcccttt     1080

atacaaaatc tacacttatt ggagaagatg tgaatcccct aatcaagctg gatgatgctg     1140

taaatgttga tgagataatg actgatactt ctaccagcta tcttctgtgc atctctgaaa     1200

ataaggaaaa tgttagggac aaaaaaaagg gcaacatttt tattggcatt gtgggagtgc     1260

agcctgccac aggcgaggtt gtgtttgata gtttccagga ctctgcttct cgttcagagc     1320

tagaaacccg gatgtcaagc ctgcagccag tagagctgct gcttccttcg gccttgtccg     1380

agcaaacaga ggcgctcatc cacagagcca catctgttag tgtgcaggat gacagaattc     1440

gagtcgaaag gatggataac atttattttg aatacagcca tgctttccag gcagttacag     1500

agttttatgc aaaagataca gttgacatca aaggttctca aattatttct ggcattgtta     1560

acttagagaa gcctgtgatt tgctctttgg ctgccatcat aaaatacctc aaagaattca     1620

acttggaaaa gatgctctcc aaacctgaga attttaaaca gctatcaagt aaaatggaat     1680

ttatgacaat taatggaaca acattaagga atctggaaat cctacagaat cagactgata     1740

tgaaaaccaa aggaagtttg ctgtgggttt tagaccacac taaaacttca tttgggagac     1800

ggaagttaaa gaagtgggtg acccagccac tccttaaatt aagggaaata aatgcccggc     1860

ttgatgctgt atcggaagtt ctccattcag aatctagtgt gtttggtcag atagaaaatc     1920

atctacgtaa attgcccgac atagagaggg gactctgtag catttatcac aaaaaatgtt     1980

ctacccaaga gttcttcttg attgtcaaaa ctttatatca cctaaagtca gaatttcaag     2040

caataatacc tgctgttaat tcccacattc agtcagactt gctccggacc gttattttag     2100

aaattcctga actcctcagt ccagtggagc attacttaaa gatactcaat gaacaagctg     2160

ccaaagttgg ggataaaact gaattattta aagacctttc tgacttccct ttaataaaaa     2220

agaggaagga tgaaattcaa ggtgttattg acgagatccg aatgcatttg caagaaatac     2280

gaaaaatact aaaaaatcct tctgcacaat atgtgacagt atcaggacag gagtttatga     2340

tagaaataaa gaactctgct gtatcttgta taccaactga ttgggtaaag gttggaagca     2400

caaaagctgt gagccgcttt cactctcctt ttattgtaga aaattacaga catctgaatc     2460

agctccggga gcagctagtc cttgactgca gtgctgaatg gcttgatttt ctagagaaat     2520

tcagtgaaca ttatcactcc ttgtgtaaag cagtgcatca cctagcaact gttgactgca     2580

ttttctccct ggccaaggtc gctaagcaag gagattactg cagaccaact gtacaagaag     2640

aaagaaaaat tgtaataaaa aatggaaggc accctgtgat tgatgtgttg ctgggagaac     2700

aggatcaata tgtcccaaat aatacagatt tatcagagga ctcagagaga gtaatgataa     2760

ttaccggacc aaacatgggt ggaaagagct cctacataaa acaagttgca ttgattacca     2820

tcatggctca gattggctcc tatgttcctg cagaagaagc gacaattggg attgtggatg     2880

gcattttcac aaggatgggt gctgcagaca atatatataa aggacagagt acatttatgg     2940

aagaactgac tgacacagca gaaataatca gaaaagcaac atcacagtcc ttggttatct     3000

tggatgaact aggaagaggg acgagcactc atgatggaat tgccattgcc tatgctacac     3060

ttgagtattt catcagagat gtgaaatcct taaccctgtt tgtcacccat tatccgccag     3120

tttgtgaact agaaaaaaat tactcacacc aggtggggaa ttaccacatg ggattcttgg     3180

tcagtgagga tgaaagcaaa ctggatccag gcgcagcaga acaagtccct gattttgtca     3240

ccttccttta ccaaataact agaggaattg cagcaaggag ttatggatta aatgtggcta     3300

aactagcaga tgttcctgga gaaattttga agaaagcagc tcacaagtca aaagagctgg     3360

aaggattaat aaatacgaaa agaaagagac tcaagtattt tgcaaagtta tggacgatgc     3420

ataatgcaca agacctgcag aagtggacag aggagttcaa catggaagaa acacagactt     3480

ctcttcttca ttaaaatgaa gactacattt gtgaacaaaa aatggagaat taaaaatacc     3540

aactgtacaa aataactctc cagtaacagc ctatctttgt gtgacatgtg agcataaaat     3600

tatgaccatg gtatattcct attggaaaca gagaggtttt tctgaagaca gtctttttca     3660

agtttctgtc ttcctaactt ttctacgtat aaacactctt gaatagactt ccactttgta     3720

attagaaaat tttatggaca gtaagtccag taaagcctta agtggcagaa tataattccc     3780

aagcttttgg agggtgatat aaaaatttac ttgatatttt tatttgtttc agttcagata     3840

attggcaact gggtgaatct ggcaggaatc tatccattga actaaaataa ttttattatg     3900

caaccagttt atccaccaag aacataagaa ttttttataa gtagaaagaa ttggccaggc     3960

atggtggctc atgcctgtaa tcccagcact ttgggaggcc aaggtaggca gatcacctga     4020

ggtcaggagt tcaagaccag cctggccaac atggcaaaac cccatcttta ctaaaaatat     4080

aaagtacatc tctactaaaa atacgaaaaa attagctggg catggtggcg cacacctgta     4140

gtcccagcta ctccggaggc tgaggcagga gaatctcttg aacctgggag gcggaggttg     4200

caatgagccg agatcacgtc actgcactcc agcttgggca acagagcaag actccatctc     4260

aaaaaaaaaa aaagaaaaaa gaaaagaaat agaattatca agcttttaaa aactagagca     4320

cagaaggaat aaggtcatga aatttaaaag gttaaatatt gtcataggat taagcagttt     4380

aaagattgtt ggatgaaatt atttgtcatt cattcaagta ataaatattt aatgaatact     4440

tgctataaaa aaaaaaaaaa aaaaaaaaaa aa                                   4472


<210>  58
<211>  6550
<212>  DNA
<213>  Homo sapiens

<400>  58
gggggcggaa ccggaaccgg cagtggcttg ggggcgggac ctcgcggact gctgtggcgg       60

cagctggagc ggcggccgcg gtggcagaac cgggggcggc cgctgcagtc tggagcccca      120

tagtgcgggg ccgcggccag gccacaggaa gagctcgagg cccgggccgc accggctgag      180

tgtgcgggcc cgcgcggctc ggagccgccg ccgcccatcg agcccctccg ggcgcgggtc      240

ggcccgccat ggggtccctg ttccggagcg agaccatgtg cctggcgcag ctcttcctgc      300

agtcgggcac ggcctacgag tgcctcagcg ccctgggcga gaaaggcctg gtccagttcc      360

gagacctcaa ccagaacgta agttctttcc aaagaaaatt tgttggtgag gtgaagaggt      420

gtgaagagct agagcgaata ttggtgtatt tggtacagga aattaataga gctgatattc      480

cccttcctga aggagaggcc agccctcctg cgccacccct gaaacaggtt ctagaaatgc      540

aggagcagtt gcagaagctc gaggttgaac tgagagaagt cactaagaac aaggagaaac      600

tgaggaaaaa cttgctggaa ctgatagagt acactcacat gctgagagtg acaaagacct      660

ttgtgaaacg caatgttgag tttgaaccca cttatgaaga attcccttcc ttagagagtg      720

attctttgtt ggattacagc tgtatgcaga ggctgggagc aaaactggga tttgtgtctg      780

gcctaattaa ccaaggaaaa gtggaagcat ttgaaaaaat gttgtggaga gtctgcaaag      840

ggtacaccat cgtgtcctat gcagaactgg atgaatccct tgaagaccct gaaacagggg      900

aagtcataaa atggtatgtc tttttaatat ccttttgggg agagcagatt ggccacaagg      960

ttaagaagat atgtgattgc taccactgcc acgtgtaccc ctatccaaac acagccgagg     1020

agcggaggga gatccaggag gggctgaaca cccgcatcca ggatctctac actgtactgc     1080

acaaaaccga ggactatttg aggcaagtgc tatgtaaagc cgccgagtct gtctacagcc     1140

gtgtgatcca ggtgaagaaa atgaaggcca tctatcacat gctgaacatg tgcagctttg     1200

acgtgaccaa caagtgcctc attgctgagg tctggtgtcc cgaggcggat ctgcaggacc     1260

tgcgccgggc actggaggag ggctcgagag agagtggtgc tacaatcccc tcattcatga     1320

atataatccc cacaaaagaa acacccccca ctcggatccg caccaacaaa ttcaccgagg     1380

gatttcagaa catcgtggat gcttatggag tcggaagcta cagagaagtc aatccagctc     1440

tctttaccat catcaccttc ccgtttttat ttgctgtgat gtttggagac ttcggacatg     1500

gctttgtgat gtttttattt gccctcttgt tggtgttaaa tgaaaatcat cccagactaa     1560

atcagtcaca agagatcatg aggatgtttt ttaatggccg gtacatcctc ctgctgatgg     1620

ggctgttctc agtgtacact ggcctcatct acaacgactg cttttcaaag tcagtcaacc     1680

tgttcggctc tgggtggaac gtgtcggcca tgtacagctc cagccaccca cccgcagagc     1740

ataagaagat ggtgctttgg aatgacagcg tcgttagaca caacagcatt ttgcagctgg     1800

atccaagcat tcctggagtg ttccgaggcc cttatcccct tggcattgat cctatttgga     1860

acttggccac aaatcgcctc acttttctaa actctttcaa aatgaaaatg tccgtgattt     1920

taggaatcat tcatatgact tttggagtca ttctgggaat atttaaccac ttgcacttca     1980

ggaagaagtt caacatttac ctggtttcca tcccggaact tctcttcatg ctctgtatct     2040

ttggatacct tatatttatg attttctaca agtggctggt tttttcagca gaaacctcca     2100

gagttgctcc cagcattctg attgaattta ttaacatgtt tttattccca gccagtaaaa     2160

caagtggcct ttacacaggg caggagtatg tccagagagt gctgctggtt gtcacagcat     2220

tgtctgtccc tgtcctcttc ttgggaaagc cactgttttt gttgtggctt cacaatgggc     2280

gtagttgctt cggggtgaac cggagtggct acacacttat aaggaaagat agtgaggaag     2340

aagtttcatt gctgggaagc caagatatag aagagggaaa tcaccaggtg gaagatggat     2400

gtagagaaat ggcgtgtgaa gagtttaatt ttggagaaat attaatgacc caagtaatcc     2460

attccatcga gtactgtctg ggatgcatct ccaacaccgc ctcctacctg aggctctggg     2520

cgcttagcct ggctcacgca cagttgtctg atgtcctgtg ggccatgctg atgcgcgtgg     2580

gcctccgcgt tgacaccacc tatggcgtct tgctactgct cccggttatc gcgctctttg     2640

cagttttgac cattttcatc cttctgatca tggaagggct ttctgcgttt cttcacgcca     2700

tacgcctcca ctgggtagaa tttcagaaca aattctacgt tggtgcaggc accaaatttg     2760

ttcctttctc attcagtcta ctttcatcaa agttcaataa cgacgacagt gtggcatgat     2820

catattgctg taaccaacaa gctttcagat ttatggagaa tgaccatgtt atagactttc     2880

acttatgtca gatttatgat aggaaaaatt ccatcttcat tactgcctta tgacatagcc     2940

aaataattct gtaagatata cctcttcctc atatgttaaa tattttgtaa agtttaccaa     3000

tttgagatat aaaaatttct tttggttttt tatgatgagc aaatataagt taatgccaaa     3060

cgttatgtta aagttatttt ttcaaataca ggatttgggg agagaagcca attttgcatg     3120

gctagttgaa aatggtatta gatacttatt tcctttaaac tttatttaaa acaaacaaca     3180

gagttaatct gtcacctgaa gttgccagat aatattttcc aacagctgaa gtagggatag     3240

ttttttaaaa aatttaatga tgggtaatca aaacattcac atttattctg ctggatttaa     3300

aaatatgtac tttttttttt tttttgagat gaagtcttgc tgtgtcacgt aggctggagt     3360

gcaatggcac gatcgtgtct cattgcaact tccgcctcct ggattcaggt gattctcctg     3420

tctcagcctc ccgagtaact gggattacag gcatgcgcca ccgtgaccag ctaatttttt     3480

tgtatttttg tagagatggg gtttcaccat gttggccagg ctggtctcga acttctgacc     3540

tcaagtgatc cacctgcctc ggcctcccta agtgctggga ttacaggcgt gagccaccat     3600

gcctggccaa aatatgcaaa tattttttat cctgtgctac ctagaattac aagtagagga     3660

ttgtttttac aattttgtct tgttttagta attggggaca atgggataaa atgacataca     3720

acaaatggtt atcccacttg tatatttttt taaagactct tatcctgtta cccttacata     3780

aaaccagtta tgataattgt atgtttggaa gataaattgt atgctgagcc ttaaaaccca     3840

gtgtgactgt agaagatata atgcggacat gatttgaatt tagtgacagc ttggctgatg     3900

tcactgaacc agaagggttt atactgagtg aaggaaaggt aaaaagtagt attttgtata     3960

tttttgtaac aaaatataaa tgaagatatt ttaccatgaa gagattgcac ttatccttga     4020

gaacagtcta aatataaatg aagatatttt accatgaaga gattgcactt atccttgaga     4080

acagtctaat gatacttttt ttactttcag actgtttcta gctaaagttc tgataaaagt     4140

attgagttaa tttaaacttt caaacactgt ttagatcagt tgaaaactaa ttcttaatag     4200

ccattgtttt ataatcttta gtttaaattc atctgtttga catttggttt tttgtgaact     4260

tgagtcagtc ctattgaaca ttttgaccta tattcttgca aattatgtta atttttcata     4320

ttttagtttg attttagaca attattttca aaaagaaacc tgactttttt tcaccttctt     4380

gacattgtga gtgatacacg ttaaaaggct atttgcccgc atcctcctct atcctgtttc     4440

gaggtagaga gcttggcact tctgttacaa gctgagagtc tggaggtgct gagtttaacg     4500

tggctgtgca gctgatttca aggcatgagc tgaacagcgt tgacacagcc gtgacttaca     4560

attaaaccct ttcaattaca gtacagattc tgtgtgctac ttgatgagat gttacccaag     4620

gccagtttgg acttactgct ttttgtccct catattaaat tatcaaatga tgccgatgaa     4680

atgcttgaaa atgattctgc tctcaaagtt atgcttccct agaaaggtgt catgtcgggc     4740

acttgtgttg ggtgactatg acatcccagc agtgctggtc aggtctcaga gttgctttca     4800

cctagagctg atgcttccac aaggggacat ttgtgttact ttgctccagg ggtctgtcat     4860

aaaaacaatg gtaactactt catccctagg aagcccaaga cttcagggca ctgttagctg     4920

attggtaaat aagggacacg atattcacgg gaattgttta ctgctcccca ctagtaattc     4980

tcatggggcc acttttttaa ctctttctaa ttaacacctc ttctcagcat agagcagagg     5040

atgcagtcat ttctctgttg aaatctatgt agtatttatg tagaatgtca ttatatgaaa     5100

agcgaattca gaatcctaac tctgggaaag cgctctctgg aaatgtagtt tgataatagt     5160

gtcttatagg ggccacggga atttgtttct ctataaagcg atgggctcca gtgtcatgtt     5220

accagagtta tcgctcagtt ttgtttgtta aggcttttgc tagaacctat tatgtatcca     5280

gtttttaaaa catacttcat tcccttgata gcagagatcc agagcacaga tggcaagttg     5340

tgtggatgat actgaatatg tttattttcc taaagataaa tgtcacgaca cgacatttct     5400

cagtttttat ttagatgttt attaccatgt gttaacagaa tcttaaaacc caagggattt     5460

cttcagtaaa ctagactttg attcaacctg ctgggctgga gactgtaatt gccgtggtca     5520

gttaaggagt gcaaagggtg ttctgtctga taggatctgg gtgagccctg cggactttcc     5580

agcagcgaaa ggacttggaa ctcctctttc gctgaatgct gctctgtttc tggaatggat     5640

attttataac aacattctgg tgtcagcatc ccctcagcag ttgtttattt aaaaattttt     5700

ttattttttt tgagacagtg tctcactctg tcacctaggc tgaagtgcag tggtgcagtc     5760

tcggctcact gcaacctctg cctcctgggt ttaagcaatt ctcctgccct agcctcccga     5820

gtagctggga ttacaggcgc ctgccacagt gcccggctaa tttttgtatt tttagtagag     5880

acagggtttc accatgttgg ccaggctggt ctcaaactcc tgacctcagg tgatctaccc     5940

accttggcct cccaaagtgc tgggattaca ggcgtgagcc accgcgcctg gccctctgca     6000

gttgtttaat aaggcacaga atacctgtag cataggtcag ccttacgatg tccatgaatt     6060

acatattcag acgttttaga gcctgataca ttttggaaaa gaaaaacaac ttctacacct     6120

attctacagt ccgcatttaa aacaataaat tcctctatta aaaacgtaaa gccgggtttg     6180

cttgcgtgcc acagggaata tatccaggaa ggttattatg aagctgtcaa atcaagatga     6240

tgggaataag gcagtttgaa cgaacagtct tcccacagtc aggccatttt tgctgatttg     6300

gtttagaatt ttcagaaata cttagtacac tccacctgtt ctttgatggg aatatctaag     6360

aaggctaggt aggttcttag ggttagcctg agtcatctag gggctcaact ccttgtgagg     6420

ggaaatgaca gtgaacaagt tagtactttg ctccacaaat gcatgaaagg acaaatttgc     6480

atcttctatc agtatttaac ttccttttgc taatgacaaa taaatatatc tatattttta     6540

aaaaaaaaaa                                                            6550


<210>  59
<211>  4731
<212>  DNA
<213>  Homo sapiens

<400>  59
tgtatgtagg ctgggagtgt ctgctgatca cttggagtgc tgtcccttgg aacaggagga       60

gtaagattga gcacccctgc agtggaccat gagtcggtaa tgcccactga ggacctctgg      120

gagccatgtc agacgaatct gcctcaggga gcgatccaga cctggacccg gacgtggagc      180

tggaggatgc ggaagaggag gaggaggagg aggaggtggc agtggaggag tgtgacaggg      240

atgatgaaga agacctgctg gatgacccat ccctggaagg catgtgtggc actgagcatg      300

cccagttggg agaagatggg cagcagccgc cgcggtgcac ttcaactacc tcatctcagt      360

ctgagccttc agagcagctt aggcgccacc aaggcaagaa cctagcctcc gaggacccca      420

aaaagaagag agctcagaag ccctcccaca tgagaagaaa catacgaaag ctactccggg      480

aggatcaatt ggagcctgtt accaaagcag cacagcaaga agagttggaa agaaggaagc      540

gcctggagca gcagaggaaa gattatgcag cccctattcc tactgttccg ctggagttcc      600

tccctgagga aattgcttta agggcaagtg acggtcccca actgcctcct cgggtcttgg      660

cccaggaagt catttgtttg gacagtagca gtggcagtga ggatgaaaaa agcagtcgag      720

atgaggtgat tgaactgagc tctggagagg aggacactct gcacattgtg gacagcagtg      780

aatctgtcag tgaagatgat gaggaagaag agaagggtgg cacccatgtc aatgatgtct      840

taaaccagcg tgacgccctt gggcgggtcc ttgtcaacct aaaccaccct ccagaggagg      900

aaaatgtctt ccttgcccca cagttggcac gggctgtgaa acctcatcag attggcggga      960

tccggttcct ttacgataac ctagtggagt ctctggagag gtttaagacc agcagtggct     1020

ttggctgtat tctggcccac agcatgggtc tggggaaaac tttgcaagtg atctctttca     1080

tcgacgtcct cttccgccac acgccagcca aaacagtcct tgccattgtg ccggttaata     1140

ctcttcagaa ttggctggca gagttcaaca tgtggcttcc acctcctgaa gccctcccgg     1200

ctgacaacaa gcctgaagaa gtccagcctc ggttctttaa agttcacatc ttgaatgatg     1260

agcacaagac gatggcatct cgtgctaaag tgatggctga ttgggtgtca gagggtggcg     1320

tgctgctgat ggggtacgag atgtacagac tcctcactct gaagaaatca tttgccacag     1380

gtagaccgaa gaaaaccaag aagcgttctc acccagtcat cattgatcta gatgaggaag     1440

atcggcagca ggagtttcgg agagagtttg agaaggcttt atgccgccct ggccctgatg     1500

tagtaatctg tgatgaggga caccgcatca aaaactgcca ggccagcacc tcacaggctc     1560

tgaagaatat ccgctctcgc cgccgggtgg tgctgactgg gtaccctctg caaaacaacc     1620

tcattgagta ctggtgcatg gtggactttg tgcgcccaga cttccttggc acccggcagg     1680

agttcagcaa catgtttgaa cgccctatcc tgaatgggca atgtattgac agcacacctc     1740

aggacgtccg cctcatgcgg taccggagcc atgtcctgca cagtcttctg gagggctttg     1800

tgcagaggag aggccacact gtgctgaaga ttcatctccc tgccaaggaa gaaaatgtga     1860

tccttgtgcg gctctccaag atccagcgag atttgtatac acagttcatg gatcgcttcc     1920

gggactgtgg tagcagcggt tggctggggc tgaaccccct taaggcattc tgtgtgtgtt     1980

gcaagatctg gaatcaccct gatgtgctgt atgaagccct tcagaaggag agcttggcca     2040

atgagcagga cctagacgtg gaagaacttg gctctgcagg gaccagtgcc cgctgtccac     2100

cacagggaac aaaaggcaag ggagaggata gcaccttggc ttcctcgatg ggagaggcaa     2160

ccaatagcaa gttcctacag ggcgttggct tcaacccttt ccaggagcga ggcaacaaca     2220

ttgtcacata tgaatgggcc aaggaccttc tgactaatta ccagactgga gtcctagaaa     2280

actctcccaa gatggtactg cttttccacc tgattgagga aagtgtgaag cttggggaca     2340

agatccttgt gtttagccag agtctttcca ccttggctct catcgaggaa ttccttggaa     2400

aacgagaagt accctgtcca cctggtaccg aggggcaagg agcacagaag tgggttcgaa     2460

acatcagcta cttccggcta gatggtagca cccctgcctt tgagagggag cggcttatta     2520

atcagttcaa tgatcccagc aacctcacca cctggctgtt ccttctctct acaagggccg     2580

gatgcttggg tgtgaatctg attggtgcca accgagtggt ggtgtttgat gcttcctgga     2640

acccttgcca tgatgcccag gcagtatgtc gggtataccg ttatggccag aaaaagccct     2700

gttacatcta tcgccttgtg gctgattaca ctctagaaaa gaagatctat gaccgtcaga     2760

tttccaagca gggcatgtca gatcgggtgg tggatgatct aaatccaatg ctgaacttca     2820

cacggaaaga ggtggaaaac ctactgcact ttgttgagaa ggagccagct ccccaagttt     2880

ccttgaacgt aaaggggatc aaggagtcag tcctgcaact ggcctgtctg aagtaccctc     2940

acctcatcac caaggagcct ttcgagcatg agtcattgct cttgaaccga aaggatcaca     3000

agctaaccaa ggctgagaaa aaagcagcaa agaaaagcta tgaggaagac aaacgcacat     3060

cagtccccta tacccgccca tcgtatgcgc agtattaccc tgccagcgat cagagcctga     3120

ccagcatccc cgccttcagc cagagaaact ggcagccaac tttgaagggt gatgaaaagc     3180

ctgtggccag tgttcgtcct gtgcagtcca cccccatccc catgatgccc cggcatgtcc     3240

cattgggagg aagtgtaagc tctgcctcca gcacaaatcc atccatgaac tttcccatca     3300

actacttgca gcgtgcagga gtccttgtgc agaaggtggt caccacgaca gatattgtta     3360

ttcctggact caacagctcc acagatgtac aggcaagaat taatgctggt gagagcatcc     3420

acatcatccg tgggacaaaa gggacgtaca tccgtaccag tgatggacgg atctttgctg     3480

tccgggcaac tggcaaacca aaggttcctg aagatggtcg gatggctgcc tcaggttccc     3540

agggaccttc ttgcgagtcc acaagcaacg gcagacacag tgcctcatca cccaaagccc     3600

ccgaccctga ggggctggcc aggcccgtct ctcctgacag cccagagatc atcagtgagc     3660

ttcagcagta tgcagatgtg gctgctgccc gggaatcccg tcagagctcc ccaagcacca     3720

atgccgccct gcctggcccc ccggcccaac ttatggacag cagtgctgtt cccgggacag     3780

ctctcggaac tgagcctcga ctagggggtc attgcctcaa tagttccctc ttggtgactg     3840

gccagccctg tggtgacagg cacccagtgc tggacttaag gggccacaag cgaaagttgg     3900

ccacaccacc tgctgcccag gagtcatccc gccggcggtc caggaagggt catctgccag     3960

cccccgtgca gccgtatgaa cacgggtatc cagtctctgg cgggtttgcc atgccacccg     4020

tctccttaaa ccataacctc accaccccct tcacctccca ggctggggag aactccctgt     4080

ttatgggcag taccccctcc tactaccagc tgtccaattt gctggcagat gcccgcctgg     4140

tgtttccagt gactactgac cctctggtgc cagcaggccc cgtcagttcc tcttccacgg     4200

ctacctcagt cactgccagc aacccctcct tcatgctcaa cccttctgtg ccagggatac     4260

tacccagcta ttcactccca ttctcacagc cactcctgtc cgagccgagg atgtttgcgc     4320

cttttccttc ccctgtcttg cccagcaacc tttcgcgggg catgtctatc tatccaggct     4380

acatgtcccc acatgcaggc tacccagctg gtggcctcct acggtcccag gtgcctccat     4440

ttgactctca tgaggttgcc gaggttgggt tcagctccaa tgatgatgag gataaagacg     4500

atgatgtgat agaggtcact gggaaatagc tagggagccc ctccccacct cacttggggc     4560

ccccagcagg ttgcccacca agctggaagg cagtgattta gaccttttga gaataggaca     4620

cttggcagga gggaaaagga agaggacaaa ggagggtggt tggccaaagt ggcagagctc     4680

tgttgctgtt taacaaaaga ggcaaaaaaa aaaaaaaaaa aaaaaaaaaa a              4731


<210>  60
<211>  7556
<212>  DNA
<213>  Homo sapiens

<400>  60
gcaggcgcct tcgcggaccg agcctgacgg agccggaggc tgggagccgc ggcggcctgg       60

ggaagtgttt ggattgtgag ctatttcaga actgttctca ggactcatta ttttaacatt      120

tgggagaaac acagccagaa gatgcacact tgactgaagg aggacaggga atctgaagac      180

tccggatgac atcagagcta cttttcaaca gccttctcaa ttttctttct cagaaagcag      240

aggctcagag cttggagaca gacgaacact gatatttgca tttaatgggg aacaaaagat      300

gaagaaggaa aaggaatata ttcactaagg attctatctg cttactgcta cagacctatg      360

tgttaaggaa ttcttctcct cctccttgcg tagaagttga tcagcactgt ggtcagactg      420

catttatctt gtcattgcca gaagaaatct tggacagaat gtaacagtac gtctctctct      480

gattgcgatg gaaggtgata aactgatact cctttattaa agttacatcg cactcaccac      540

agaaaaccat tctttaaagt gaatagaaac caagcccttg tgaacacttc tattgaacat      600

gactcatgga gaagagcttg gctctgatgt gcaccaggat tctattgttt taacttacct      660

agaaggatta ctaatgcatc aggcagcagg gggatcaggt actgccgttg acaaaaagtc      720

tgctgggcat aatgaagagg atcagaactt taacatttct ggcagtgcat ttcccacctg      780

tcaaagtaat ggtccagttc tcaatacaca tacatatcag gggtctggca tgctgcacct      840

caaaaaagcc agactgttgc agtcttctga ggactggaat gcagcaaagc ggaagaggct      900

gtctgattct atcatgaatt taaacgtaaa gaaggaagct ttgctagctg gcatggttga      960

cagtgtgcct aaaggcaaac aggatagcac attactggcc tctttgcttc agtcattcag     1020

ctctaggctg cagactgttg ctctgtcaca acaaatcagg cagagcctca aggagcaagg     1080

atatgccctc agtcatgatt ctttaaaagt ggagaaggat ttaaggtgct atggtgttgc     1140

atcaagtcac ttaaaaactt tgttgaagaa aagtaaagtt aaagatcaaa agcctgatac     1200

gaatcttcct gatgtgacta aaaacctcat cagagatagg tttgcagagt ctcctcatca     1260

tgttggacaa agtggaacaa aggtcatgag tgaaccgttg tcatgtgctg caagattaca     1320

ggctgttgca agcatggtgg aaaaaagggc tagtcctgcc acctcaccta aacctagtgt     1380

tgcttgtagc cagttagcat tacttctgtc aagcgaagcc catttgcagc agtattctcg     1440

agaacacgct ttaaaaacgc aaaatgcaaa tcaagcagca agtgaaagac ttgctgctat     1500

ggccagattg caagaaaatg gccagaagga tgttggcagt taccagctcc caaaaggaat     1560

gtcaagccat cttaatggtc aggcaagaac atcatcaagc aaactgatgg ctagcaaaag     1620

tagtgctaca gtgtttcaaa atccaatggg tatcattcct tcttccccta aaaatgcagg     1680

ttataagaac tcactggaaa gaaacaatat aaaacaagct gctaacaata gtttgctttt     1740

acatcttctt aaaagccaga ctatacctaa gccaatgaat ggacacagtc acagtgagag     1800

aggaagcatt tttgaggaaa gtagtacacc tacaactatt gatgaatatt cagataacaa     1860

tcctagtttt acagatgaca gcagtggtga tgaaagttct tattccaact gtgttcccat     1920

agacttgtct tgcaaacacc gaactgaaaa atcagaatct gaccaacctg tttccctgga     1980

taacttcact caatccttgc taaacacttg ggatccaaaa gtcccagatg tagatatcaa     2040

agaagatcaa gatacctcaa agaattctaa gctaaactca caccagaaag taacacttct     2100

tcaattgcta cttggccata agaatgaaga aaatgtagaa aaaaacacca gccctcaggg     2160

agtacacaat gatgtgagca agttcaatac acaaaattat gcaaggactt ctgtgataga     2220

aagccccagt acaaatcgga ctactccagt gagcactcca cctttactta catcaagcaa     2280

agcagggtct cccatcaatc tctctcaaca ctctctggtc atcaaatgga attccccacc     2340

atatgtctgc agtactcagt ctgaaaagct aacaaatact gcatctaacc actcaatgga     2400

ccttacaaaa agcaaagacc caccaggaga gaaaccagcc caaaatgaag gtgcacagaa     2460

ctctgcaacg tttagtgcca gtaagctgtt acaaaattta gcacaatgtg gaatgcagtc     2520

atccatgtca gtggaagagc agagacccag caaacagctg ttaactggaa acacagataa     2580

accgataggt atgattgata gattaaatag ccctttgctc tcaaataaaa caaatgcagt     2640

tgaagaaaat aaagcattta gtagtcaacc aacaggtcct gaaccagggc tttctggttc     2700

tgaaatagaa aatctgcttg aaagacgtac tgtcctccag ttgctcctgg ggaaccccaa     2760

caaagggaag agtgaaaaaa aagagaaaac tcccttaaga gatgaaagta ctcaggaaca     2820

ctcagagaga gctttaagtg aacaaatact gatggtgaaa ataaaatctg agccttgtga     2880

tgacttacaa attcctaaca caaatgtgca cttgagccat gatgctaaga gtgccccatt     2940

cttgggtatg gctcctgctg tgcagagaag cgcacctgcc ttaccagtgt ccgaagactt     3000

taaatcggag cctgtttcac ctcaggattt ttctttctcc aagaatggtc tgctaagtcg     3060

attgctaaga caaaatcaag atagttacct ggcagatgat tcagacagga gtcacagaaa     3120

taatgaaatg gcacttctag aatcaaagaa tctttgcatg gtccctaaga aaaggaagct     3180

ttatactgag ccattagaaa atccatttaa aaagatgaaa aacaacattg ttgatgctgc     3240

aaacaatcac agtgccccag aagtactgta tgggtccttg cttaaccagg aagagctgaa     3300

atttagcaga aatgatcttg aatttaaata tcctgctggt catggctcag ccagcgaaag     3360

tgaacacagg agttgggcca gagagagcaa aagctttaat gttctgaaac agctgcttct     3420

ctcagaaaac tgtgtgcgag atttgtcccc gcacagaagt aactctgtgg ctgacagtaa     3480

aaagaaagga cacaaaaata atgtgaccaa cagcaaacct gaatttagca tttcttcttt     3540

aaatggactg atgtacagtt ccactcagcc cagcagttgc atggataaca ggacattttc     3600

atacccaggt gtagtaaaaa ctcctgtgag tcctactttc cctgagcact tgggctgtgc     3660

agggtctaga ccagaatctg ggcttttgaa tgggtgttcc atgcccagtg agaaaggacc     3720

cattaagtgg gttatcactg atgcggagaa gaatgagtat gaaaaagact ctccaagatt     3780

gaccaaaacc aacccaatac tatattacat gcttcaaaaa ggaggcaatt ctgttaccag     3840

tcgagaaaca caagacaagg acatttggag ggaggcttca tctgctgaaa gtgtctcaca     3900

ggtcacagcc aaagaagagt tacttcctac tgcagaaacg aaagcttctt tctttaattt     3960

aagaagccct tacaatagcc atatgggaaa taatgcttct cgcccacaca gcgcaaatgg     4020

agaagtttat ggacttctgg gaagcgtgct aacgataaag aaagaatcag aataaaatgt     4080

acctgccatc cagttttgga tctttttaaa actaatgagt atgaacttga gatctgtata     4140

aataagagca tgatttgaaa aaaagcatgg tataattgaa acttttttca ttttgaaaag     4200

tattggttac tggtgatgtt gaaatatgca tactaatttt tgcttaacat tagatgtcat     4260

gaggaaacta ctgaactagc aattggttgt ttaacacttc tgtatgcatc agataacaac     4320

tgtgagtagc ctatgaatga aattctttta taaatattag gcataaatta aaatgtaaaa     4380

ctccattcat agtggattaa tgcattttgc tgcctttatt agggtacttt attttgcttt     4440

tcagaagtca gcctacataa cacattttta aagtctaaac tgttaaacaa ctctttaaag     4500

gataattatc caataaaaaa aaacctagtg ctgattcaca gcttattatc caattcaaaa     4560

ataaattaga aaaatatatg cttacatttt tcacttttgc taaaaagaaa aaaaaaaggt     4620

gtttattttt aactcttgga agaggttttg tggttcccaa tgtgtctgtc ccaccctgat     4680

ccttttcaat atatatttct ttaaaccttg tgctacttag taaaaattga ttacaattga     4740

gggaagtttg atagatcctt taaaaaaaag gcagatttcc attttttgta ttttaactac     4800

tttactaaat taatactcct ccttttacag aattagaaaa gttaacattt atctttaggt     4860

ggtttcctga aaagttgaat atttaagaaa ttgtttttaa cagaagcaaa atggcttttc     4920

tttggacagt tttcaccatc tcttgtaaaa gttaattctc accattcctg tggtacctgc     4980

gagtgttatg accaggattc cttaaacctg aactcagacc acttgcatta gaaccatctg     5040

gagcacttgt tttaaaatgc agattcatag gcagcatctc agatctacag aacaagaatc     5100

tctgctaagt ggacctggaa tcttccatct gcatcttaac atgctctcta ggtgtttctt     5160

gtgtttgaga accatgactt atgactttcc tcagaacatg agactgtaaa acaaaaacaa     5220

aaaactatgt gatgcctcta ttttccccaa tacagtcaca catcagctca aaatttgcaa     5280

tattgtagtt catatattac cgttatgtct ttggaaatcg ggttcagaac actttttatg     5340

acaaaaattg ggtggagggg ataactttca tatctggctc aacatctcag gaaaatctgt     5400

gattatttgt gtgttctaat gagtaacatc tacttagtta gccttaggga tggaaaaaca     5460

gggccactta ccaaactcag gtgattccag gatggtttgg aaacttctcc tgaatgcatc     5520

cttaaccttt attaaaacca ttgtcctaag aacaatgcca acaaagctta caacatttag     5580

tttaaaccca agaagggcac taaactcaga ttgactaaat aaaaagtaca aagggcacat     5640

atacgtgaca gaattgtaca caatcactcc attggatctt ttactttaaa gtagtgatga     5700

aaagtacatg ttgatactgt cttagaagaa attaatatat tagtgaagcc acatggggtt     5760

tcagttgcga aacaggtctg tttttatgtt cagtttgtac aatccacaat tcattcacca     5820

gatattttgt tcttaattgt gaaccaggtt agcaaatgac ctatcaaaaa ttattctata     5880

atcactacta gttaggatat tgatttaaaa ttgttctact tgaagtggtt tctaagattt     5940

ttatattaaa aataggtgtg atttcctaat atgatctaaa accctaaatg gttatttttc     6000

ctcagaatga tttgtaaata gctactggaa atattataca gtaataggag tgggtattat     6060

gcaacatcat ggagaagtga aggcataggc ttattctgac ataaaattcc actggccagt     6120

tgaatatatt ctattccatg tccatactat gacaatctta ttgtcaacac tatataaata     6180

agcttttaaa caagtcattt ttcttgatcg ttgtggaagg tttggagcct tagaggtatg     6240

tcagaaaaaa tatgttggta ttctcccttg ggtaggggga aatgaccttt ttacaagaga     6300

gtgaaattta ggtcagggaa aagaccaagg gccagcattg ctacttttgt gtgtgtgtgt     6360

gtgggttttg ttttgttttt ttggttggct ggttgttttc gttgttgtta acaaaggaat     6420

gagaatatgt aatacttaaa taaacatgac cacgaagaat gctgttctga tttactagag     6480

aatgttccca atttgaattt agggtgattt taaagaacag tgagaaaggg catacatcca     6540

cagattcact ttgtttatgc atatgtagat acaaggatgc acatatacac attttcaagg     6600

actattttag atatctagac aatttcttct aataaagtca tttgtgaaag ggtactacag     6660

cttattgaca tcagtaaggt agcattcatt acctgtttat tctctgctgc atcttacaga     6720

agagtaaact ggtgagagta tatattttat atatatatat atatatatat atataatatg     6780

tatatatata tatattgact tgttacatga agatgttaaa atcggttttt aaaggtgatg     6840

taaatagtga tttccttaat gaaaaataca tattttgtat tgttctaatg caacagaaaa     6900

gccttttaat ctctttggtt cctgtatatt ccatgtataa gtgtaaatat aatcagacag     6960

gtttaaaagt tgtgcatgta tgtatacagt tgcaagtctg gacaaatgta tagaataaac     7020

cttttattta agttgtgatt acctgctgca tgaaaagtgc atgggggacc ctgtgcatct     7080

gtgcatttgg caaaatgtct taacaaatca gatcagatgt tcatcctaac atgacagtat     7140

tccatttctg gacatgacgt ctgtggttta agctttgtga aagaatgtgc tttgattcga     7200

agggtcttaa agaatttttt taatcgtcaa ccacttttaa acataaagaa ttcacacaac     7260

tactttcatg aattttttaa tcccattgca aacattattc caagagtatc ccagtattag     7320

caatactgga atataggcac attaccattc atagtaagaa ttctggtgtt tacacaacca     7380

aatttgatgc gatctgctca gtaatataat ttgccatttt tattagaaat ttaatttctt     7440

catgtgatgt catgaaactg tacatactgc agtgtgaatt tttttgtttt gttttttaat     7500

cttttagtgt ttacttcctg cagtgaattt gaataaatga gaaaaaatgc attgtc         7556


<210>  61
<211>  6032
<212>  DNA
<213>  Homo sapiens

<400>  61
aaccaaccag ccacccgtca gagagggaca tgcgcactcc agggaaggca ctcaaaagtg       60

gggggcagga aagatgtaca ttgaagatgt cagtttctac atgtgggaag tagacattga      120

aggctttatg gtttacagac aagatcttta gaagataagc actaaaggac caaggaaata      180

aataccagaa atcaagaaga gcacacacta ttttccttca tcaatccata gaaccctaat      240

gcttctttag ttccatcaaa cacagaggaa tgaccaccat ggcagatggc aacagaggat      300

gtcaacaatt ttttggagag agaagaggta ctcccttata gggactcgta aagacataga      360

gcatctggaa attaactgcc tccattacac tgctgagtca cacacaacgc ttgttatgtt      420

ttcatcactt ctctccagaa ggctacatta ttggaatttt gaagtcatga aaacatcaga      480

tgaaccaacc tgcaacacct tggattcaga ttggaagata aagagaaagt ttaaagaatg      540

tggcctataa aggcgggtac ctggaaatat taaccgactc acactgtaaa aatgagacca      600

gtttctaaac aatagagatt gtcttagtac aacatcaagg ttcaagacaa atgttgaact      660

aaaaacttta cactccccac ccccacttca gacaggtacc agcattggtg aattatgatt      720

ttccttagtc agaagcactc atttttaccc atgtagacca tccttaggaa ttaaatattg      780

gttatttaat gtagattata atgggaagct gatttttttc acaatggcat atttcaagga      840

cttggttcca aactgagctg aagcttccca atgcgttttg tacagtctgg gaaaaactgt      900

gctgcactgg cccacttttg aaggccatca tgctctgtaa tataaggata tcatcttatt      960

gctgatatct ttggagagtc cctagcagac acagaaaatg aatggaggca aagagtgtga     1020

cggaggggac aaggaaggag gtcttccagc tatacaagtt cctgtgggtt ggcagcgtcg     1080

tgtggatcaa aatggagtgc tttatgtcag tcccagtggg tctttgttat cttgcttgga     1140

gcaggttaaa acatacctgc ttactgatgg aacatgcaag tgtggcttgg aatgtcctct     1200

tattcttccc aaggtattta attttgatcc tggagctgct gtgaaacaga gaaccgcaga     1260

agatgttaag gcagatgaag atgtcacaaa gctatgcata cataaaagaa aaattattgc     1320

agtggccaca cttcataaaa gcatggaagc cccacatcct tctctggtgc tcaccagtcc     1380

cggaggagga acaaatgcaa ctccagtagt accttctcgg gcagcaactc caagatcagt     1440

aagaaataag tctcatgaag gaattacaaa ttctgtaatg cctgaatgta agaatccttt     1500

caagttaatg attggatcat caaatgccat gggaaggcta tatgtacaag aactgcctgg     1560

aagccaacaa caagaactcc accctgtcta cccccgacag agattgggca gcagtgaaca     1620

tggacagaaa tctccattcc gtggcagcca tggaggcctg cccagcccag cgtcatcagg     1680

ttcccagata tatggagatg gttcaatctc tccaaggact gacccacttg gaagtcctga     1740

tgttttcaca agaagtaatc ctggttttca tggagctccc aattctagtc ctattcacct     1800

gaataggact cctctttctc caccttcagt aatgctacat ggttctcctg tacagtcatc     1860

ctgtgcaatg gctggaagga ctaatatacc tctttcccca accttgacta caaagagtcc     1920

agtaatgaaa aaaccaatgt gtaatttttc aactaatatg gaaataccac gagcaatgtt     1980

ccaccacaaa ccaccccaag gcccacctcc ccctcctcca ccttcttgtg ctcttcagaa     2040

aaagccatta acatctgaga aagatccact tggcattctt gaccctattc ctagtaaacc     2100

agtgaatcag aaccctgtta tcattaatcc aaccagtttc cattcaaatg tccactctca     2160

ggtacctatg atgaatgtaa gcatgcctcc tgctgttgtt cctttgccaa gtaatctccc     2220

attgccaact gtaaaacctg gtcacatgaa tcatgggagt catgtacaaa gagttcagca     2280

ttcagcttca acctccctgt ccccttctcc agtgacatcc cccgtgcaca tgatggggac     2340

tggaattgga aggattgagg catcgcccca aagatcacgc tcatcttcca catcatcaga     2400

tcatggaaat ttcatgatgc cacctgtagg accccaggcc acttctagtg gtattaaggt     2460

tccacccagg tcaccaaggt caacaatagg gtccccaagg ccatcaatgc catcaagccc     2520

ttctaccaag tccgatggac atcatcagta caaggatatc cctaacccat taattgctgg     2580

aataagtaat gtactaaata ccccaagcag tgcagctttt cctactgcat ctgccggaag     2640

tagttctgta aagagtcagc ctggtttgct gggaatgcct ttaaatcaga tcttgaacca     2700

gcacaatgct gcctcctttc cagcaagtag tttactctca gcagcagcca aagcacagct     2760

agcaaatcaa aacaaacttg ctggtaacaa cagtagcagc agtagcaatt ctggagctgt     2820

tgccggcagt ggcaacactg aaggacatag cactttaaac accatgttcc ctcctactgc     2880

caacatgctt ctcccaacag gtgaagggca aagtggtcga gcagcactaa gagataagct     2940

gatgtctcag caaaaagacg cattgcggaa aagaaaacaa ccacctacga cagtgttgag     3000

tttgctcaga cagtctcaaa tggatagttc tgcagttcct aaacctggac ctgacttgct     3060

aaggaagcag ggtcagggtt catttcccat cagttcaatg tctcagttac tacagtctat     3120

gagttgtcaa agctctcact tgagtagcaa tagtaccccg ggttgtgggg cctcaaatac     3180

tgctttgcct tgctctgcta accagctgca ttttacagat cccagtatga actctagtgt     3240

tcttcagaac atacctttaa gaggggaagc cgtgcactgc cacaatgcaa acactaactt     3300

tgttcacagt aacagtccag tccccaacca ccatcttgca ggtttaataa atcagattca     3360

ggctagcggg aactgtggga tgctcagtca gtcgggcatg gctttaggaa attccttaca     3420

tcccaatcca cctcagtcaa gaatttcaac gtcctccact ccagtgatac caaacagcat     3480

tgttagcagc tataatcaaa caagttctga agcaggcggt tcaggaccat catcctccat     3540

agccatagcg ggcaccaacc accctgccat cacaaagaca acatctgttc ttcaagatgg     3600

cgtcatagtc accactgcag ctggaaaccc actgcagagt cagctaccca ttgggagtga     3660

ttttcctttt gttggccagg agcacgcact tcattttcca tccaacagca cttcaaacaa     3720

ccatcttcca caccccttga accccagcct cctcagttct ctacctatct ctttgccagt     3780

gaatcaacag catctcctaa accagaatct attaaatatc ctccagcctt cagcaggaga     3840

aggtgatatg tcatcaataa acaatacttt gagtaaccat caactgactc atctacagtc     3900

gctgttaaac aacaatcaga tgtttcctcc aaatcagcaa cagcagcaac ttctccaggg     3960

gtaccagaat ctccaggcgt tccaaggaca gtccacaatt ccttgcccag ctaacaataa     4020

ccccatggct tgtctgtttc agaactttca ggtgagaatg caggaagatg cagctctcct     4080

aaacaaaaga ataagcactc agcctgggct cacagcactt cctgagaatc caaacactac     4140

acttccacct tttcaagata caccttgtga gttgcaaccg aggattgacc catctcttgg     4200

tcaacaggtg aaggatggcc tcgttgtggg tggcccaggt gatgcttccg tagatgccat     4260

ttacaaagca gttgtcgatg cagccagcaa aggaatgcag gttgtcatca ccactgcagt     4320

caacagtaca actcagatca gccccattcc agctctgagt gccatgagtg ccttcactgc     4380

ctcaattggt gacccattaa atctctccag tgctgtcagt gcggtcattc atggacggaa     4440

catgggaggt gttgatcatg atggtaggct gaggaattca agaggggctc ggctgcccaa     4500

gaatctagac catgggaaaa atgtgaacga aggagatggg tttgaatatt tcaagtcagc     4560

aagttgccac acatccaaaa aacagtggga cggggagcaa agccccagag gggagcgaaa     4620

caggtggaag tacgaggaat ttttagatca tccaggccat atccacagta gtccttgtca     4680

tgaaaggccc aacaatgtct ctacactgcc atttctgcct ggggaacagc acccaatact     4740

gttaccacca agaaactgtc caggggataa aattctagag gaaaatttca ggtataataa     4800

ctacaaaaga actatgatga gttttaagga gagactagag aacactgtgg aaagatgtgc     4860

acacataaat gggaatagac ctcgacagag tcggggattt ggagagctgc taagcactgc     4920

aaagcaagac ctggtcctag aggagcagtc tccaagttcc tcaaatagtt tggaaaattc     4980

tctggtcaaa gactacatcc attacaatgg agactttaat gccaaaagcg ttaatgggtg     5040

tgtgcctagc ccttcagatg ctaaaagcat tagtagtgaa gatgacctaa ggaacccaga     5100

ctccccctct tcaaatgaat tgatacatta tagaccaagg acgttcaatg ttggcgactt     5160

ggtctggggc caaatcaaag gactgacttc ctggcctgga aaattagtaa gagaagacga     5220

cgttcacaat tcatgtcaac aaagccccga ggaagggaag gtggagcccg agaagttgaa     5280

gacactaaca gaaggtttgg aagcctacag ccgtgtccgg aaaaggaaca gaaaaagtgg     5340

aaagctaaat aaccatttag aagctgctat tcatgaggcc atgagtgaac tggacaaaat     5400

gtctgggact gtacaccaaa tcccacaggg tgacagacaa atgagacccc ccaaacccaa     5460

gaggaggaag atctccagat aacagagact actccactaa tgcgcagtgt ttattaaagg     5520

aacatgcaca gatgtatctg tatataggta ttgatatagc cacagttata tcaatattta     5580

gactatggca gatagctacc accaccacag ggtgctaaaa gaaacagtga tacaaaattt     5640

ttttgatcag gaaggataat gaatgctgga aaagccaatc aaagtctctg tgtgatgaga     5700

gtgatcaatg gtcaagagat tactgagaaa ctctttttct ataatactaa attgtgatta     5760

taagaaatag tccaaatgtt tctgaagaat tttcaatgtt gtatatagaa aatacagaat     5820

ttcatggtga tatcagaaat gtaaatattg tacagtattg tcatgtacaa gcgtacctaa     5880

tgcacacttt atcttttatt gtacaaagaa atagtgtaca aaattctttg gtttctatgg     5940

agtacaccta ccagagacta ccagtgtaaa gtgataaata aaaatacaac ctaaatgctt     6000

ttctatgata atgtaaaaaa aaaaaaaaaa aa                                   6032


<210>  62
<211>  2288
<212>  DNA
<213>  Homo sapiens

<400>  62
tcgtcggagc gcggctcagc ggcgcggcgg agactcggca cggcggcggc caggcgcagg       60

cgggcgggcg gagcagcgga cggcgccgag gccgccccac gcgccgggct cgcggcggcg      120

cagcgcgccg gagtggtcgg ggcccgcggc cgctcgcgcc tctcgatggg cagctcgcac      180

ttgctcaaca agggcctgcc gcttggcgtc cgacctccga tcatgaacgg gcccctgcac      240

ccgcggcccc tggtggcatt gctggatggc cgggactgca cagtggagat gcccatcctg      300

aaggacgtgg ccactgtggc cttctgcgac gcgcagtcca cgcaggagat ccatgagaag      360

gtcctgaacg aggctgtggg ggccctgatg taccacacca tcactctcac cagggaggac      420

ctggagaagt tcaaagccct ccgcatcatc gtccggattg gcagtggttt tgacaacatc      480

gacatcaagt cggccgggga tttaggcatt gccgtctgca acgtgcccgc ggcgtctgtg      540

gaggagacgg ccgactcgac gctgtgccac atcctgaacc tgtaccggcg ggccacctgg      600

ctgcaccagg cgctgcggga gggcacacga gtccagagcg tcgagcagat ccgcgaggtg      660

gcgtccggcg ctgccaggat ccgcggggag accttgggca tcatcggact tggtcgcgtg      720

gggcaggcag tggcgctgcg ggccaaggcc ttcggcttca acgtgctctt ctacgaccct      780

tacttgtcgg atggcgtgga gcgggcgctg gggctgcagc gtgtcagcac cctgcaggac      840

ctgctcttcc acagcgactg cgtgaccctg cactgcggcc tcaacgagca caaccaccac      900

ctcatcaacg acttcaccgt caagcagatg agacaagggg ccttcctggt gaacacagcc      960

cggggtggcc tggtggatga gaaggcgctg gcccaggccc tgaaggaggg ccggatccgc     1020

ggcgcggccc tggatgtgca cgagtcggaa cccttcagct ttagccaggg ccctctgaag     1080

gatgcaccca acctcatctg caccccccat gctgcatggt acagcgagca ggcatccatc     1140

gagatgcgag aggaggcggc acgggagatc cgcagagcca tcacaggccg gatcccagac     1200

agcctgaaga actgtgtcaa caaggaccat ctgacagccg ccacccactg ggccagcatg     1260

gaccccgccg tcgtgcaccc tgagctcaat ggggctgcct ataggtaccc tccgggcgtg     1320

gtgggcgtgg cccccactgg catcccagct gctgtggaag gtatcgtccc cagcgccatg     1380

tccctgtccc acggcctgcc ccctgtggcc cacccgcccc acgccccttc tcctggccaa     1440

accgtcaagc ccgaggcgga tagagaccac gccagtgacc agttgtagcc cgggaggagc     1500

tctccagcct cggcgcctgg gcagagggcc cggaaaccct cggaccagag tgtgtggagg     1560

aggcatctgt gtggtggccc tggcactgca gagactggtc cgggctgtca ggaggcggga     1620

gggggcagcg ctgggcctcg tgtcgcttgt cgtcgtccgt cctgtgggcg ctctgccctg     1680

tgtccttcgc gttcctcgtt aagcagaaga agtcagtagt tattctccca tgaacgttct     1740

tgtctgtgta cagtttttag aacattacaa aggatctgtt tgcttagctg tcaacaaaaa     1800

gaaaacctga aggagcattt ggaagtcaat ttgaggtttt tttttttgtt tttttttttt     1860

ttgtatgttg gaacgtgccc cagaatgagg cagttggcaa acttctcagg acaatgaatc     1920

cttcccgttt ttctttttat gccacacagt gcattgtttt ttctacctgc ttgtcttatt     1980

tttagaataa tttagaaaaa caaaacaaag gctgtttttc ctaattttgg catgaacccc     2040

cccttgttcc aaatgaagac ggcatcacga agcagctcca aaaggaaaag cttgggcggt     2100

gcccagcgtg cccgctgccc atcgacgtct gtcctgggga cgtggagggt ggcagcgtcc     2160

ccgcctgcac cagtgccgtc ctgctgatgt ggtaggctag caatattttg gttaaaatca     2220

tgtttgtgac tgtaaccatt tgtatgaatt attttaaaga aataaaaatc ctggaaagag     2280

ccagcgtg                                                              2288


<210>  63
<211>  6500
<212>  DNA
<213>  Homo sapiens

<400>  63
tcctgctata cccacagtgg tggtcatctc ttctgatctt cacagccaat cagctcccaa       60

ggcccctgac ctcagctcag cttttgtaga tccttatgac accatccttt aagactggaa      120

tcctagggca ggctgtttta ttcccgcctc ctgaggcctt tctgaggatc tgtggcttgt      180

ctctgtcctg agggtgaaga tggatgacag atgctaccca gtaatctttc cagatgagcg      240

gaatttccgc cccttcactt ccgactctct ggctgcaatt gagaagcgga ttgccatcca      300

aaaggagaaa aagaagtcta aagaccagac aggagaagta ccccagcctc ggcctcagct      360

tgacctaaag gcctccagga agttgcccaa gctctatggc gacattcctc gtgagctcat      420

aggaaagcct ctggaagact tggacccatt ctaccgaaat cataagacat ttatggtgtt      480

aaacagaaag aggacaatct accgcttcag tgccaagcat gccttgttca tttttgggcc      540

tttcaattca atcagaagtt tagccattag agtctcagtc cattcattgt tcagcatgtt      600

cattatcggc accgttatca tcaactgcgt gttcatggct acagggcctg ctaaaaacag      660

caacagtaac aatactgaca ttgcagagtg tgtcttcact gggatttata tttttgaagc      720

tttgattaaa atattggcaa gaggtttcat tctggatgag ttttctttcc ttcgagatcc      780

atggaactgg ctggactcca ttgtcattgg aatagcgatt gtgtcatata ttccaggaat      840

caccatcaaa ctattgcccc tgcgtacctt ccgtgtgttc agagctttga aagcaatttc      900

agtagtttca cgtctgaagg tcatcgtggg ggccttgcta cgctctgtga agaagctggt      960

caacgtgatt atcctcacct tcttttgcct cagcatcttt gccctggtag gtcagcagct     1020

cttcatggga agtctgaacc tgaaatgcat ctcgagggac tgtaaaaata tcagtaaccc     1080

ggaagcttat gaccattgct ttgaaaagaa agaaaattca cctgaattca aaatgtgtgg     1140

catctggatg ggtaacagtg cctgttccat acaatatgaa tgtaagcaca ccaaaattaa     1200

tcctgactat aattatacga attttgacaa ctttggctgg tcttttcttg ccatgttccg     1260

gctgatgacc caagattcct gggagaagct ttatcaacag accctgcgta ctactgggct     1320

ctactcagtc ttcttcttca ttgtggtcat tttcctgggc tccttctacc tgattaactt     1380

aaccctggct gttgttacca tggcatatga ggagcagaac aagaatgtag ctgcagagat     1440

agaggccaag gaaaagatgt ttcaggaagc ccagcagctg ttaaaggagg aaaaggaggc     1500

tctggttgcc atgggaattg acagaagttc acttacttcc cttgaaacat catattttac     1560

cccaaaaaag agaaagctct ttggtaataa gaaaaggaag tccttctttt tgagagagtc     1620

tgggaaagac cagcctcctg ggtcagattc tgatgaagat tgccaaaaaa agccacagct     1680

cctagagcaa accaaacgac tgtcccagaa tctatcactg gaccactttg atgagcatgg     1740

agatcctctc caaaggcaga gagcactgag tgctgtcagc atcctcacca tcaccatgaa     1800

ggaacaagaa aaatcacaag agccttgtct cccttgtgga gaaaacctgg catccaagta     1860

cctcgtgtgg aactgttgcc cccagtggct gtgcgttaag aaggtcctga gaactgtgat     1920

gactgacccg tttactgagc tggccatcac catctgcatc atcatcaaca ctgtcttctt     1980

ggccatggag catcacaaga tggaggccag ttttgagaag atgttgaata tagggaattt     2040

ggttttcact agcattttta tagcagaaat gtgcctaaaa atcattgcgc tcgatcccta     2100

ccactacttt cgccgaggct ggaacatttt tgacagcatt gttgctcttc tgagttttgc     2160

agatgtaatg aactgtgtac ttcaaaagag aagctggcca ttcttgcgtt ccttcagagt     2220

gctcagggtc ttcaagttag ccaaatcctg gccaactttg aacacactaa ttaagataat     2280

cggcaactct gtcggagccc ttggaagcct gactgtggtc ctggtcattg tgatctttat     2340

tttctcagta gttggcatgc agctttttgg ccgtagcttc aattcccaaa agagtccaaa     2400

actctgtaac ccgacaggcc cgacagtctc atgtttacgg cactggcaca tgggggattt     2460

ctggcactcc ttcctagtgg tattccgcat cctctgcggg gaatggatcg aaaatatgtg     2520

ggaatgtatg caagaagcga atgcatcatc atcattgtgt gttattgtct tcatattgat     2580

cacggtgata ggaaaacttg tggtgctcaa cctcttcatt gccttactgc tcaattcctt     2640

tagcaatgag gaaagaaatg gaaacttaga aggagaggcc aggaaaacta aagtccagtt     2700

agcactggat cgattccgcc gggctttttg ttttgtgaga cacactcttg agcatttctg     2760

tcacaagtgg tgcaggaagc aaaacttacc acagcaaaaa gaggtggcag gaggctgtgc     2820

tgcacaaagc aaagacatca ttcccctggt catggagatg aaaaggggct cagagaccca     2880

ggaggagctt ggtatactaa cctctgtacc aaagaccctg ggcgtcaggc atgattggac     2940

ttggttggca ccacttgcgg aggaggaaga tgacgttgaa ttttctggtg aagataatgc     3000

acagcgcatc acacaacctg agcctgaaca acaggcctat gagctccatc aggagaacaa     3060

gaagcccacg agccagagag ttcaaagtgt ggaaattgac atgttctctg aagatgagcc     3120

tcatctgacc atacaggatc cccgaaagaa gtctgatgtt accagtatac tatcagaatg     3180

tagcaccatt gatcttcagg atggctttgg atggttacct gagatggttc ccaaaaagca     3240

accagagaga tgtttgccca aaggctttgg ttgctgcttt ccatgctgta gcgtggacaa     3300

gagaaagcct ccctgggtca tttggtggaa cctgcggaaa acctgctacc aaatagtgaa     3360

acacagctgg tttgagagct ttattatctt tgtgattctg ctgagcagtg gggcactgat     3420

atttgaagat gttcaccttg agaaccaacc caaaatccaa gaattactaa attgtactga     3480

cattattttt acacatattt ttatcctgga gatggtacta aaatgggtag ccttcggatt     3540

tggaaagtat ttcaccagtg cctggtgctg ccttgatttc atcattgtga ttgtctctgt     3600

gaccaccctc attaacttaa tggaattgaa gtccttccgg actctacgag cactgaggcc     3660

tcttcgtgcg ctgtcccagt ttgaaggaat gaaggtggtg gtcaatgctc tcataggtgc     3720

catacctgcc attctgaatg ttttgcttgt ctgcctcatt ttctggctcg tattttgtat     3780

tctgggagta tacttctttt ctggaaaatt tgggaaatgc attaatggaa cagactcagt     3840

tataaattat accatcatta caaataaaag tcaatgtgaa agtggcaatt tctcttggat     3900

caaccagaaa gtcaactttg acaatgtggg aaatgcttac ctcgctctgc tgcaagtggc     3960

aacatttaag ggctggatgg atattatata tgcagctgtt gattccacag agaaagaaca     4020

acagccagag tttgagagca attcactcgg ttacatttac ttcgtagtct ttatcatctt     4080

tggctcattc ttcactctga atctcttcat tggcgttatc attgacaact tcaaccaaca     4140

gcagaaaaag ttaggtggcc aagacatttt tatgacagaa gaacagaaga aatactataa     4200

tgcaatgaaa aaattaggat ccaaaaaacc tcaaaaaccc attccacggc ctctgaacaa     4260

atgtcaaggt ctcgtgttcg acatagtcac aagccagatc tttgacatca tcatcataag     4320

tctcattatc ctaaacatga ttagcatgat ggctgaatca tacaaccaac ccaaagccat     4380

gaaatccatc cttgaccatc tcaactgggt ctttgtggtc atctttacgt tagaatgtct     4440

catcaaaatc tttgctttga ggcaatacta cttcaccaat ggctggaatt tatttgactg     4500

tgtggtcgtg cttctttcca ttgttagtac aatgatttct accttggaaa atcaggagca     4560

cattcctttc cctccgacgc tcttcagaat tgtccgcttg gctcggattg gccgaatcct     4620

gaggcttgtc cgggctgcac gaggaatcag gactctcctc tttgctctga tgatgtcgct     4680

tccttctctg ttcaacattg gtcttctact ctttctgatt atgtttatct atgccattct     4740

gggtatgaac tggttttcca aagtgaatcc agagtctgga atcgatgaca tattcaactt     4800

caagactttt gccagcagca tgctctgtct cttccagata agcacatcag caggttggga     4860

ttccctgctc agccccatgc tgcgatcaaa agaatcatgt aactcttcct cagaaaactg     4920

ccacctccct ggcatagcca catcctactt tgtcagttac attatcatct cctttctcat     4980

tgttgtcaac atgtacattg ctgtgatttt agagaacttc aatacagcca ctgaagaaag     5040

tgaggaccct ttgggtgaag atgactttga catattttat gaagtgtggg aaaagtttga     5100

cccagaagca acacaattta tcaaatattc tgccctttct gactttgctg atgccttgcc     5160

tgagcctttg cgtgtcgcaa agccaaataa atatcaattt ctagtaatgg acttgcccat     5220

ggtgagtgaa gatcgcctcc actgcatgga tattcttttc gccttcaccg ctagggtact     5280

cggtggctct gatggcctag atagtatgaa agcaatgatg gaagagaagt tcatggaagc     5340

caatcctctc aagaagttgt atgaacccat agtcaccacc accaagagaa aggaagagga     5400

aagaggtgct gctattattc aaaaggcctt tcgaaagtac atgatgaagg tgaccaaggg     5460

tgaccaaggt gaccaaaatg acttggaaaa cgggcctcat tcaccactcc agactctttg     5520

caatggagac ttgtctagct ttggggtggc caagggcaag gtccactgtg actgagccct     5580

cacctccacg cctacctcat agcttcacag ccttgccttc agcctctgag ctccaggggt     5640

cagcagctta gtgtatcaac agggagtgga ttcaccaaat tagccattcc attttctttt     5700

ctggctaaaa taaatgatat ttcaatttca ttttaaataa tacttacaga gatataagat     5760

aaggctactt gacaaccagt ggtactatta taataaggaa gaagacacca ggaaggactg     5820

taaaaggaca taccaatttt aggattgaaa tagttcaggc cgggcgcagt ggctcatgcc     5880

tgtaatccca gcactttgag aggccaaggc aggtggatca cgaggtcaag agatcgagac     5940

catcctggcc aacatgatga aactccgtct ctactaaaaa tacaaaaatt agctgggcat     6000

ggtggcgtgc gcctgtagtc ccagctactt gggaggctga ggcaggagaa tcgcttaaac     6060

ctgggagacg gaggttgcag tgagccaaga tcgtgccact gcactccagc ctggtgacag     6120

agtgagactc tgtttcaaaa aagaaaagaa aagaaacatg gttcaaatta tatctaaaca     6180

aaaaagaata agaaacaaaa aacacattaa aattttaagt tgtattttct atgtttctag     6240

atacatcatt tttgtttgat attttcctga tgcaagtatg tggtttatca catgtagctc     6300

ttttgcatgc taaatgaaaa ttcaaaactt gccaataaat gaatagctta ttgcagacat     6360

tttttaccaa cattaattat tttgggtttg tttaaaacct agaggcacaa tcttgacttg     6420

tcaattacta ccctttcaca agctaccatc tcagatatat atatatatat aaattcaata     6480

aagctttctg tttgtgttcc                                                 6500


<210>  64
<211>  3371
<212>  DNA
<213>  Homo sapiens

<400>  64
cggaaggccg gaggggcagt ccgccgcggg ggcgagcgcg catgcgcctt cctgggaccc       60

acggcaggcg cgaatcccag cggccggcgg gcggcgggga tacttctaca tagacataat      120

caagttttga ctatttggaa accaagcatc attaaaattc tctcaaactc ctaattgcga      180

agaatcgata acatttcaag aagtgataac atttctctga acaagaaaag aagtgattga      240

ccacgtttta aaagtactct ggcactggtg ctgtgttttc ttcccctccc taaatttgaa      300

gaactatgga gaaatggtac ttgatgacag tagtggtttt aataggacta acagtacgat      360

ggacagtgtc tcttaattct tattcaggtg ctggtaaacc gcctatgttt ggtgattatg      420

aagctcagag acactggcaa gaaataactt ttaatttacc ggtcaaacaa tggtatttta      480

acagcagtga taacaattta cagtattggg gattggatta cccacctctt acagcttatc      540

atagtctcct atgtgcatat gtggcaaagt ttataaatcc agactggatt gctctccata      600

catcacgtgg atatgagagt caggcacata agctcttcat gcgtacaaca gttttaattg      660

ctgatctgct gatttacata cctgcagtgg ttttgtactg ttgttgctta aaagaaatct      720

caactaagaa aaagattgct aatgcattat gcatcttgct gtatccaggc cttattctta      780

tagactatgg acattttcaa tataattctg tgagtcttgg ctttgctttg tggggtgttc      840

ttggaatatc ttgtgactgc gacctcctag ggtcactggc attttgctta gctataaatt      900

ataaacagat ggaactttac cacgccttgc catttttttg ctttttactt ggcaagtgtt      960

ttaaaaaagg cctcaaagga aaggggtttg tgttgctagt taagctagct tgtattgttg     1020

tggcttcctt cgttctctgc tggctgccat tctttacaga aagggaacaa accctgcagg     1080

ttctaagaag actcttcccg gttgatcgtg gattatttga ggataaagta gccaatattt     1140

ggtgcagctt caatgtcttt ctgaagatta aggatatttt gccacgtcac atccaattaa     1200

taatgagctt ttgttctacg tttttgagcc tgcttcctgc atgcataaaa ttaatacttc     1260

agccctcttc caaaggattc aaatttacac tggttagctg tgcgctatca ttctttttat     1320

tttctttcca agtacatgaa aaatccattc tcttggtgtc actaccagtc tgcttagttt     1380

taagtgaaat tccttttatg tctacttggt ttttacttgt gtcaacattt agtatgctac     1440

ctcttctatt gaaggatgaa ctcctaatgc cctctgttgt gacaacaatg gcatttttta     1500

tagcttgtgt aacttccttt tcaatatttg aaaagacttc tgaagaagaa ctgcagttga     1560

aatccttttc catttctgtg aggaaatatc ttccatgttt tacatttctt tccagaatta     1620

tacaatattt gtttcttatc tcagtcatca ctatggtgct tctgacgttg atgactgtca     1680

cactggatcc tcctcagaaa ctaccggact tgttttctgt attggtgtgt tttgtatctt     1740

gcttgaactt cctgttcttc ttggtatact ttaacattat tattatgtgg gattccaaaa     1800

gtggaagaaa tcagaagaaa atcagctagc tgtattccta aacaaattgt ttcctaaaca     1860

aatgtgaaaa tgtgaacagt gctgaaaggt tttgtgaact ttttgctatg tataaatgaa     1920

attaccattt tgagaaccat ggaaccacag gaaaggaaat ggtgaaaagt cattgttgtc     1980

tacacaaaat aaatgtatat ggagaccaaa gaccaatgga ggcttgtcta agtactgctt     2040

ggccaaaaca tgtggtttta ttattcacag ctattcaagt ggggaaaaaa gagaaacatg     2100

tccttaatcc cattgtttac tcaggaaatg cactttttaa atgtctttaa aaaactgaga     2160

aatatttctt gatatttgct ttgtctaaac ctacttcctt catcagacca tatagtgagc     2220

ttcatgggag aattgagccc cttcttttta atggaaatca ctaattttgg tattcaaact     2280

tacattttag aatgcaagta gtgtgtattt cactgtttag aagtcatatc ttagggaatt     2340

aaatttgtga taatcttttt aattactgag aaggcaattt aaactgcttg aagtttgaat     2400

atgccttatt acacatgcaa atttgattgt tttaacaagg caaataaacc ataatcttat     2460

ttatttccaa gaatgcatat tttaatacaa ttaaaaatga attttcctga atttaaatgt     2520

aagctttaac ttaactttaa gtggtttgag tgaagtcttc taaattacac ataatcactg     2580

gttctaaact tccagaacca ttctgtttaa ttaaacatta tattatatat atattattat     2640

tgacatggtt cagggttacc actgccagag cattgattca tgttaacttc atcctattaa     2700

tactgtatca ccctgtatta gcagaagcca atatttatta tagtattcaa ctggtaaaaa     2760

taatacatga tatccatgtt gcagtttctc atataaagat atgttttctt tagcctctgt     2820

aataaagata atcattttcc catcaacatt ttttaaggaa tatatttctt ctttcataag     2880

atagccatta aactatatta agtggtggta tattttaata tagtgcaaat caaaccacat     2940

acaaaaaaaa actggttcta gacacggaca gtcacaggct gatataagaa ggtatgtgtt     3000

tctaagtctg gtaaaggaag tgggtttaga caaagcaaaa atctagaaag gtttctttct     3060

caaagcaaat gtgcataaag actcaaaggg caggtcaacg cagaatagca gccttgaatc     3120

actgccgaat cagcaagaac attgctgtcc atggtcacca tctgtaatca ctgtgcccaa     3180

atgtcagcat cttggctggc tggtgtagct ttatttttaa aaatattttt tgtaatagta     3240

cacttgtgtt taacatagaa tgttgactta gataaatgat gaggaagtta taaataattg     3300

gagtagcata actttattat ttggaaataa aagtattatg tacatatatt agtaaaatga     3360

aatgcacctg a                                                          3371


<210>  65
<211>  1689
<212>  DNA
<213>  Homo sapiens

<400>  65
aggaaatgag gtgagaagta cgtccactct tctgtccagc ttttaacaat ctaactaatg       60

ccctctccag ggtcacccta gaatcagatc tgctccccag catcttctgt ttcctggtga      120

gtgattcctg ctactttgga tggccatgac gggctggagc tgccttgtga caggagcagg      180

agggtttctg ggacagagga tcatccgcct cttggtgaag gagaaggagc tgaaggagat      240

cagggtcttg gacaaggcct tcggaccaga attgagagag gaattttcta aactccagaa      300

caagaccaag ctgacagtgc tggaaggaga cattctggat gagccattcc tgaagagagc      360

ctgccaggac gtctcggtca tcatccacac cgcctgtatc attgatgtct tcggtgtcac      420

tcacagagag tctatcatga atgtcaatgt gaaaggtacc cagctcctgt tagaggcctg      480

tgtccaagct agtgtgccag tcttcatcta caccagtagc atagaggtag ccgggcccaa      540

ctcctacaag gaaatcatcc agaatggcca tgaagaagag cctctggaaa acacatggcc      600

cgctccatac ccacacagca aaaagcttgc tgagaaggct gtactggcgg ctaacgggtg      660

gaatctgaaa aacggcggca ccctgtacac ttgtgcctta cgacccatgt atatctatgg      720

ggaaggaagc cgattccttt ctgctagtat aaacgaggcc ctgaacaaca atgggatcct      780

gtcaagtgtt ggaaagttct ccactgttaa cccagtctat gttggcaatg tggcctgggc      840

ccacattctg gccttgaggg ccctgcagga ccccaagaag gccccaagca tccgaggaca      900

gttctactat atctcagatg acacgcctca ccaaagctat gataacctta attacaccct      960

gagcaaagag ttcggcctcc gccttgattc cagatggagc tttcctttat ccctgatgta     1020

ttggattggc ttcctgctgg aaatagtgag cttcctactc aggccaattt acacctatcg     1080

accgcccttc aaccgccaca tagtcacatt gtcaaatagc gtattcacct tctcttataa     1140

gaaggctcag cgagatctgg cgtataagcc actctacagc tgggaggaag ccaagcagaa     1200

aacggtggag tgggttggtt cccttgtgga ccggcacaag gagaccctga agtccaagac     1260

tcagtgattt aaggatgaca gagatgtgca tgtgggtatt gttaggagat gtcatcaagc     1320

tccaccctcc tggcctcata cagaaagtga caagggcaca agctcaggtc ctgctgcctc     1380

cctttcatac aatggccaac ttattgtatt cctcatgtca tcaaaacctg cgcagtcatt     1440

ggcccaacaa gaaggtttct gtcctaatca tataccagag gaaagaccat gtggtttgct     1500

gttaccaaat ctcagtagct gattctgaac aatttaggga ctcttttaac ttgagggtcg     1560

ttttgactac tagagctcca tttctactct taaatgagaa aggatttcct ttctttttaa     1620

tcttccattc cttcacatag tttgataaaa agatcaataa atgtttgaat gtttaatgtg     1680

aaaaaaaaa                                                             1689


<210>  66
<211>  3927
<212>  DNA
<213>  Homo sapiens

<400>  66
taccgcgccg gagccttccg cagctgccgc ttcagtccga aggaggaagg gaaccaaccc       60

actttctcgg cgccgcggct cttttctaaa agtaatgtga aaacctttgc atcttctgat      120

agtctagcca aggtccaaga agtagcaagc tggcttttgg aaatgaatca ggaactgctc      180

tctgtgggca gcaaaagacg acgaactgga ggctctctga gaggtaaccc ttcctcaagc      240

caggtagatg aagaacagat gaatcgtgtg gtagaggagg aacagcaaca gcaactcaga      300

caacaagagg aggagcacac tgcaaggaat ggtgaagttg ttggagtaga acctagacct      360

ggaggccaaa atgattccca gcaaggacag ttggaagaaa acaataatag atttatttcg      420

gtagatgagg actcctcagg aaaccaagaa gaacaagagg aagatgaaga acatgctggt      480

gaacaagatg aggaggatga ggaggaggag gagatggacc aggagagtga cgattttgat      540

cagtctgatg atagtagcag agaagatgaa catacacata ctaacagtgt cacgaactcc      600

agtagtattg tggacctgcc cgttcaccaa ctctcctccc cattctatac aaaaacaaca      660

aaaatgaaaa gaaagttgga ccatggttct gaggtccgct ctttttcttt gggaaagaaa      720

ccatgcaaag tctcagaata tacaagtacc actgggcttg taccatgttc agcaacacca      780

acaacttttg gggacctcag agcagccaat ggccaagggc aacaacgacg ccgaattaca      840

tctgtccagc cacctacagg cctccaggaa tggctaaaaa tgtttcagag ctggagtgga      900

ccagagaaat tgcttgcttt agatgaactc attgatagtt gtgaaccaac acaagtaaaa      960

catatgatgc aagtgataga accccagttt caacgagact tcatttcatt gctccctaaa     1020

gagttggcac tctatgtgct ttcattcctg gaacccaaag acctgctaca agcagctcag     1080

acatgtcgct actggagaat tttggctgaa gacaaccttc tctggagaga gaaatgcaaa     1140

gaagagggga ttgatgaacc attgcacatc aagagaagaa aagtaataaa accaggtttc     1200

atacacagtc catggaaaag tgcatacatc agacagcaca gaattgatac taactggagg     1260

cgaggagaac tcaaatctcc taaggtgctg aaaggacatg atgatcatgt gatcacatgc     1320

ttacagtttt gtggtaaccg aatagttagt ggttctgatg acaacacttt aaaagtttgg     1380

tcagcagtca caggcaaatg tctgagaaca ttagtgggac atacaggtgg agtatggtca     1440

tcacaaatga gagacaacat catcattagt ggatctacag atcggacact caaagtgtgg     1500

aatgcagaga ctggagaatg tatacacacc ttatatgggc atacttccac tgtgcgttgt     1560

atgcatcttc atgaaaaaag agttgttagc ggttctcgag atgccactct tagggtttgg     1620

gatattgaga caggccagtg tttacatgtt ttgatgggtc atgttgcagc agtccgctgt     1680

gttcaatatg atggcaggag ggttgttagt ggagcatatg attttatggt aaaggtgtgg     1740

gatccagaga ctgaaacctg tctacacacg ttgcaggggc atactaatag agtctattca     1800

ttacagtttg atggtatcca tgtggtgagt ggatctcttg atacatcaat ccgtgtttgg     1860

gatgtggaga cagggaattg cattcacacg ttaacagggc accagtcgtt aacaagtgga     1920

atggaactca aagacaatat tcttgtctct gggaatgcag attctacagt taaaatctgg     1980

gatatcaaaa caggacagtg tttacaaaca ttgcaaggtc ccaacaagca tcagagtgct     2040

gtgacctgtt tacagttcaa caagaacttt gtaattacca gctcagatga tggaactgta     2100

aaactatggg acttgaaaac gggtgaattt attcgaaacc tagtcacatt ggagagtggg     2160

gggagtgggg gagttgtgtg gcggatcaga gcctcaaaca caaagctggt gtgtgcagtt     2220

gggagtcgga atgggactga agaaaccaag ctgctggtgc tggactttga tgtggacatg     2280

aagtgaagag cagaaaagat gaatttgtcc aattgtgtag acgatatact ccctgccctt     2340

ccccctgcaa aaagaaaaaa agaaaagaaa aagaaaaaaa tcccttgttc tcagtggtgc     2400

aggatgttgg cttggggcaa cagattgaaa agacctacag actaagaagg aaaagaagaa     2460

gagatgacaa accataactg acaagagagg cgtctgctgt ctcatcacat aaaaggcttc     2520

acttttgact gagggcagct ttgcaaaatg agactttcta aatcaaacca ggtgcaatta     2580

tttctttatt ttcttctcca gtggtcattg ggcagtgtta atgctgaaac atcattacag     2640

attctgctag cctgttcttt taccactgac agctagacac ctagaaagga actgcaataa     2700

tatcaaaaca agtactggtt gactttctaa ttagagagca tctgcaacaa aaagtcattt     2760

ttctggagtg gaaaagctta aaaaaattac tgtgaattgt ttttgtacag ttatcatgaa     2820

aagctttttt tttttttttt ttgccaacca ttgccaatgt caatcaatca cagtattagc     2880

ctctgttaat ctatttactg ttgcttccat atacattctt caatgcatat gttgctcaaa     2940

ggtggcaagt tgtcctgggt tctgtgagtc ctgagatgga tttaattctt gatgctggtg     3000

ctagaagtag gtcttcaaat atgggattgt tgtcccaacc ctgtactgta ctcccagtgg     3060

ccaaacttat ttatgctgct aaatgaaaga aagaaaaaag caaattattt ttttttattt     3120

tttttctgct gtgacgtttt agtcccagac tgaattccaa atttgctcta gtttggttat     3180

ggaaaaaaga ctttttgcca ctgaaacttg agccatctgt gcctctaaga ggctgagaat     3240

ggaagagttt cagataataa agagtgaagt ttgcctgcaa gtaaagaatt gagagtgtgt     3300

gcaaagctta ttttctttta tctgggcaaa aattaaaaca cattccttgg aacagagcta     3360

ttacttgcct gttctgtgga gaaacttttc tttttgaggg ctgtggtgaa tggatgaacg     3420

tacatcgtaa aactgacaaa atattttaaa aatatataaa acacaaaatt aaaataaagt     3480

tgctggtcag tcttagtgtt ttacagtatt tgggaaaaca actgttacag ttttattgct     3540

ctgagtaact gacaaagcag aaactattca gtttttgtag taaaggcgtc acatgcaaac     3600

aaacaaaatg aatgaaacag tcaaatggtt tgcctcattc tccaagagcc acaactcaag     3660

ctgaactgtg aaagtggttt aacactgtat cctaggcgat cttttttcct ccttctgttt     3720

atttttttgt ttgttttatt tatagtctga tttaaaacaa tcagattcaa gttggttaat     3780

tttagttatg taacaacctg acatgatgga ggaaaacaac ctttaaaggg attgtgtcta     3840

tggtttgatt cacttagaaa ttttattttc ttataactta agtgcaataa aatgtgtttt     3900

ttcatgttaa aaaaaaaaaa aaaaaaa                                         3927


<210>  67
<211>  2219
<212>  DNA
<213>  Homo sapiens

<400>  67
gcacaaccag aatttgccaa aacaggaaat aggtgtttca tatatacggc tctaaccttc       60

tctctctgca ccttccttct gtcaatagat gaaacaaata cttcatcctg ctctggaaac      120

cactgcaatg acattattcc cagtgctgtt gttcctggtt gctgggctgc ttccatcttt      180

tccagcaaat gaagataagg atcccgcttt tactgctttg ttaaccaccc aaacacaagt      240

gcaaagggag attgtgaata agcacaatga actgaggaga gcagtatctc cccctgccag      300

aaacatgctg aagatggaat ggaacaaaga ggctgcagca aatgcccaaa agtgggcaaa      360

ccagtgcaat tacagacaca gtaacccaaa ggatcgaatg acaagtctaa aatgtggtga      420

gaatctctac atgtcaagtg cctccagctc atggtcacaa gcaatccaaa gctggtttga      480

tgagtacaat gattttgact ttggtgtagg gccaaagact cccaacgcag tggttggaca      540

ttatacacag gttgtttggt actcttcata cctcgttgga tgtggaaatg cctactgtcc      600

caatcaaaaa gttctaaaat actactatgt ttgccaatat tgtcctgctg gtaattgggc      660

taatagacta tatgtccctt atgaacaagg agcaccttgt gccagttgcc cagataactg      720

tgacgatgga ctatgcacca atggttgcaa gtacgaagat ctctatagta actgtaaaag      780

tttgaagctc acattaacct gtaaacatca gttggtcagg gacagttgca aggcctcctg      840

caattgttca aacagcattt attaaatacg cattacacac cgagtagggc tatgtagaga      900

ggagtcagat tatctactta gatttggcat ctacttagat ttaacatata ctagctgaga      960

aattgtaggc atgtttgata cacatttgat ttcaaatgtt tttcttctgg atctgctttt     1020

tattttacaa aaatattttt catacaaatg gttaaaaaga aacaaaatct ataacaacaa     1080

ctttggattt ttatatataa actttgtgat ttaaatttac tgaatttaat tagggtgaaa     1140

attttgaaag ttgtattctc atatgactaa gttcactaaa accctggatt gaaagtgaaa     1200

attatgttcc tagaacaaaa tgtacaaaaa gaacaatata attttcacat gaacccttgg     1260

ctgtagttgc ctttcctagc tccactctaa ggctaagcat cttcaaagac gttttcccat     1320

atgctgtctt aattcttttc actcattcac ccttcttccc aatcatctgg ctggcatcct     1380

cacaattgag ttgaagctgt tcctcctaaa acaatcctga cttttatttt gccaaaatca     1440

atacaatcct ttgaattttt tatctgcata aattttacag tagaatatga tcaaaccttc     1500

atttttaaac ctctcttctc tttgacaaaa cttccttaaa aaagaataca agataatata     1560

ggtaaatacc ctccactcaa ggaggtagaa ctcagtcctc tcccttgtga gtcttcacta     1620

aaatcagtga ctcacttcca aagagtggag tatggaaagg gaaacatagt aactttacag     1680

gggagaaaaa tgacaaatga cgtcttcacc aagtgatcaa aattaacgtc accagtgata     1740

agtcattcag atttgttcta gataatcttt ctaaaaattc ataatcccaa tctaattatg     1800

agctaaaaca tccagcaaac tcaagttgaa ggacattcta caaaatatcc ctggggtatt     1860

ttagagtatt cctcaaaact gtaaaaatca tggaaaataa gggaatcctg agaaacaatc     1920

acagaccaca tgagactaag gagacatgtg agccaaatgc aatgtgcttc ttggatcaga     1980

tcctggaaca gaaaaagatc agtaatgaaa aaactgatga agtctgaata gaatctggag     2040

tatttttaac agtagtgttg atttcttaat cttgataaat atagcagggt aatgtaagat     2100

gataacgtta gagaaactga aactgggtga gggctatcta ggaattctct gtactatctt     2160

accaaatttt cggtaagtct aagaaagcaa tgcaaaataa aaagtgtctt gaaaaaaaa      2219


<210>  68
<211>  4069
<212>  DNA
<213>  Homo sapiens

<400>  68
gcaggccgaa tggtggattt aattggccgg agtttagggc gcgcttggcc cgcgtgggtc       60

agctgatcgc gcactgaggg tgcgatcccg ggctccccat tccttcctgg ggcgcctccc      120

cggcccaggg ccaactgggt cccggtgtcg gcaggcctgg ggtcggcgac ggctgctctt      180

ttcgttctgt cgcctgcccg atggacgagc ctcccgggaa gcccctcagc tgtgaggaga      240

aggaaaagtt aaaggagaaa ttagcattct tgaaaaggga atacagcaag acactagccc      300

gccttcagcg tgcccaaaga gctgaaaaga ttaagcattc tattaagaaa acagtagaag      360

aacaagattg tttgtctcag caggatctct caccgcagct aaaacactca gaacctaaaa      420

ataaaatatg tgtttatgac aagttacaca tcaaaaccca tcttgatgaa gaaactggag      480

aaaagacatc tatcacactt gatgttgggc ctgagtcctt taaccctgga gatggcccag      540

gaggattacc tatacaaaga acagatgaca cccaagaaca ttttccccac agggtcagtg      600

accctagtgg tgagcaaaag cagaagctgc caagcagaag aaagaagcag cagaagagga      660

catttatttc acaggagaga gactgtgtct ttggcactga ttcactcaga ttgtctggga      720

aaagactaaa ggaacaggaa gaaatcagta gcaaaaatcc tgctagatca ccagtaactg      780

aaataagaac tcacctttta agtcttaaat ctgaacttcc agattctcca gaaccagtta      840

cagaaattaa tgaagacagt gtattaattc caccaactgc ccaaccagaa aaaggtgttg      900

atacattcct aagaagacct aatttcacca gggcgactac agttccttta cagactctat      960

cagatagcgg tagtagtcag caccttgaac acattcctcc taaaggtagc agtgaactta     1020

ctactcacga cctaaaaaac attagattta cttcacctgt aagtttggag gcacaaggca     1080

aaaaaatgac tgtctctaca gataacctcc ttgtaaataa agctataagt aaaagtggcc     1140

aactgcccac aagttctaat ttagaggcaa atatttcatg ttctctaaat gaactcacct     1200

acaataactt accagcaaat gaaaaccaaa acttaaaaga acaaaatcaa acagagaaat     1260

ctttaaaatc tcccagtgac actcttgatg gcaggaatga aaatcttcag gaaagtgaga     1320

ttctaagtca acctaagagt cttagcctgg aagcaacctc tcctctttct gcagaaaaac     1380

attcttgcac agtgcctgaa ggccttctgt ttcctgcaga atattatgtt agaacaacac     1440

gaagcatgtc caattgccag aggaaagtag ccgtggaggc tgtcattcag agtcatttgg     1500

atgtcaagaa aaaagggttt aaaaataaaa ataaggatgc aagtaaaaat ttaaaccttt     1560

ccaatgagga aactgaccaa agtgaaatta ggatgtctgg cacatgcaca ggacaaccaa     1620

gttcaagaac ctctcagaaa cttctctcat taactaaagt cagctctccc gctgggccca     1680

ctgaagataa tgacttgtct aggaaggcag ttgcccaagc acctggtaga agatacacag     1740

gaaaaagaaa atcagcctgc accccagcat cagatcattg tgaaccactt ttgccaactt     1800

ctagcctgtc gattgttaac aggtccaagg aagaagtcac ctcacacaaa tatcagcacg     1860

aaaaattatt tattcaagtg aaagggaaga aaagtcgtca tcaaaaagag gattcccttt     1920

cttggagtaa tagtgcttat ttatccttgg atgatgatgc tttcacggct ccatttcata     1980

gggatggaat gctgagttta aagcaactac tgtcttttct cagtatcaca gactttcagt     2040

tacctgatga agactttgga cctcttaagc ttgaaaaagt gaagtcctgc tcagaaaaac     2100

cagtggagcc ctttgagtca aaaatgtttg gagagagaca tcttaaagag ggaagctgta     2160

tttttccaga ggaactgagt cctaaacgca tggatacaga aatggaggac ttagaagagg     2220

accttattgt tctaccagga aaatcacatc ccaaaaggcc aaactcgcaa agccagcata     2280

caaagacggg cctttcttca tccatattac tttatactcc tttaaatacg gttgcgcctg     2340

atgataatga caggcctacc acagacatgt gttcacctgc tttccccatc ttaggtacta     2400

ctccagcctt tggccctcaa ggctcctatg aaaaagcatc tacagaagtt gctggacgaa     2460

cttgctgcac accccaactt gctcatttga aagactcagt ctgtcttgcc agtgatacta     2520

aacaattcga cagttcaggc agcccagcaa aaccacatac caccctgcaa gtgtcaggca     2580

ggcaaggaca acctacctgt gactgtgact ctgtcccgcc aggaacacct ccacccattg     2640

agtcattcac ttttaaagaa aatcagctct gtagaaacac atgccaggag ctgcataaac     2700

attccgtcga acagactgaa acagcagagc ttcctgcttc tgatagcata aacccaggca     2760

acctacaatt ggtttcagag ttaaagaatc cttcaggttc ctgttccgta gatgtgagtg     2820

ccatgttttg ggaaagagcc ggttgtaaag agccatgtat cataactgct tgcgaagatg     2880

tagtttctct ttggaaagct ctggatgctt ggcagtggga aaaactttat acctggcact     2940

tcgcagaggt tccagtatta cagatagttc cagtgcctga tgtgtataat ctcgtgtgtg     3000

tagctttggg aaatttggaa atcagagaga tcagggcatt gttttgttcc tctgatgatg     3060

aaagtgaaaa gcaagtacta ctgaagtctg gaaatataaa agctgtgctt ggcctgacaa     3120

agaggaggct agttagtagc agtgggaccc tttctgatca acaagtagaa gtcatgacgt     3180

ttgcagaaga tggaggaggc aaagaaaacc aatttttgat gccccctgag gagactatac     3240

taacttttgc tgaggtccaa gggatgcaag aagctctgct tggtactact attatgaaca     3300

acattgttat ttggaattta aaaactggtc aactcctgaa aaagatgcac attgatgatt     3360

cttaccaagc ttcagtctgt cacaaagcct attctgaaat ggggcttctc tttattgtcc     3420

tgagtcatcc ctgtgccaaa gagagtgagt cgttgcgaag ccctgtgttt cagctcattg     3480

tgattaaccc taagacgact ctcagcgtgg gtgtgatgct gtactgtctt cctccagggc     3540

aggctggcag gttcctggaa ggtgacgtga aagatcactg tgcagcagca atcttgactt     3600

ctggaacaat tgccatttgg gacttacttc tcggtcagtg tactgccctc ctcccacctg     3660

tctctgacca acattggtct tttgtgaaat ggtcgggtac agactctcat ttgctggctg     3720

gacaaaaaga tggaaatata tttgtatacc actattcata agttagggta aagtgaaaac     3780

acaattttct ggatatattg ggcctcttag tattttttgg agttttaaat ataaaggaga     3840

atatctgaat gacacttaaa atgattgctt gtttatgtcc agacagactt attttttatt     3900

ctaatgatgg tagcaccact gatcttggat gtacatttat gtatactttg agaaaaaggg     3960

ttttaggttg atttttgtaa tttcccacat ttgtacatgt gcttttaaag gtgtacataa     4020

agcttcaaat ggcaataaat atttattttt atacattcaa aaaaaaaaa                 4069


<210>  69
<211>  5460
<212>  DNA
<213>  Homo sapiens

<400>  69
cgggcgcagg gagccgccgc cggggctgta ggcgccaagg ccatgtccga ctcgtgggtc       60

ccgaactccg cctcgggcca ggacccaggg ggccgccgga gggcctgggc cgagctgctg      120

gcgggaaggg tcaagaggga aaaatataat cctgaaaggg cacagaaatt aaaggaatca      180

gctgtgcgcc tcctgcgaag ccatcaggac ctgaatgccc ttttgcttga ggtagaaggt      240

ccactgtgta aaaaattgtc tctcagcaaa gtgattgact gtgacagttc tgaggcctat      300

gctaatcatt ctagttcatt tataggctct gctttgcagg atcaagcctc aaggctgggg      360

gttcccgtgg gtattctctc agccgggatg gttgcctcta gcgtgggaca gatctgcacg      420

gctccagcgg agaccagtca ccctgtgctg ctgactgtgg agcagagaaa gaagctgtct      480

tccctgttag agtttgctca gtatttattg gcacacagta tgttctcccg tctttccttc      540

tgtcaagaat tatggaaaat acagagttct ttgttgcttg aagcggtgtg gcatcttcac      600

gtacaaggca ttgtgagcct gcaagagctg ctggaaagcc atcccgacat gcatgctgtg      660

ggatcgtggc tcttcaggaa tctgtgctgc ctttgtgaac agatggaagc atcctgccag      720

catgctgacg tcgccagggc catgctttct gattttgttc aaatgtttgt tttgagggga      780

tttcagaaaa actcagatct gagaagaact gtggagcctg aaaaaatgcc gcaggtcacg      840

gttgatgtac tgcagagaat gctgattttt gcacttgacg ctttggctgc tggagtacag      900

gaggagtcct ccactcacaa gatcgtgagg tgctggttcg gagtgttcag tggacacacg      960

cttggcagtg taatttccac agatcctctg aagaggttct tcagtcatac cctgactcag     1020

atactcactc acagccctgt gctgaaagca tctgatgctg ttcagatgca gagagagtgg     1080

agctttgcgc ggacacaccc tctgctcacc tcactgtacc gcaggctctt tgtgatgctg     1140

agtgcagagg agttggttgg ccatttgcaa gaagttctgg aaacgcagga ggttcactgg     1200

cagagagtgc tctcctttgt gtctgccctg gttgtctgct ttccagaagc gcagcagctg     1260

cttgaagact gggtggcgcg tttgatggcc caggcattcg agagctgcca gctggacagc     1320

atggtcactg cgttcctggt tgtgcgccag gcagcactgg agggcccctc tgcgttcctg     1380

tcatatgcag actggttcaa ggcctccttt gggagcacac gaggctacca tggctgcagc     1440

aagaaggccc tggtcttcct gtttacgttc ttgtcagaac tcgtgccttt tgagtctccc     1500

cggtacctgc aggtgcacat tctccaccca cccctggttc ccggcaagta ccgctccctc     1560

ctcacagact acatctcatt ggccaagaca cggctggccg acctcaaggt ttctatagaa     1620

aacatgggac tctacgagga tttgtcatca gctggggaca ttactgagcc ccacagccaa     1680

gctcttcagg atgttgaaaa ggccatcatg gtgtttgagc atacggggaa catcccagtc     1740

accgtcatgg aggccagcat attcaggagg ccttactacg tgtcccactt cctccccgcc     1800

ctgctcacac ctcgagtgct ccccaaagtc cctgactccc gtgtggcgtt tatagagtct     1860

ctgaagagag cagataaaat ccccccatct ctgtactcca cctactgcca ggcctgctct     1920

gctgctgaag agaagccaga agatgcagcc ctgggagtga gggcagaacc caactctgct     1980

gaggagcccc tgggacagct cacagctgca ctgggagagc tgagagcctc catgacagac     2040

cccagccagc gtgatgttat atcggcacag gtggcagtga tttctgaaag actgagggct     2100

gtcctgggcc acaatgagga tgacagcagc gttgagatat caaagattca gctcagcatc     2160

aacacgccga gactggagcc acgggaacac atggctgtgg acctcctgct gacgtctttc     2220

tgtcagaacc tgatggctgc ctccagtgtc gctcccccgg agaggcaggg tccctgggct     2280

gccctcttcg tgaggaccat gtgtggacgt gtgctccctg cagtgctcac ccggctctgc     2340

cagctgctcc gtcaccaggg cccgagcctg agtgccccac atgtgctggg gttggctgcc     2400

ctggccgtgc acctgggtga gtccaggtct gcgctcccag aggtggatgt gggtcctcct     2460

gcacctggtg ctggccttcc tgtccctgcg ctctttgaca gcctcctgac ctgtaggacg     2520

agggattcct tgttcttctg cctgaaattt tgtacagcag caatttctta ctctctctgc     2580

aagttttctt cccagtcacg agatactttg tgcagctgct tatctccagg ccttattaaa     2640

aagtttcagt tcctcatgtt cagattgttc tcagaggccc gacagcctct ttctgaggag     2700

gacgtagcca gcctttcctg gagacccttg caccttcctt ctgcagactg gcagagagct     2760

gccctctctc tctggacaca cagaaccttc cgagaggtgt tgaaagagga agatgttcac     2820

ttaacttacc aagactggtt acacctggag ctggaaattc aacctgaagc tgatgctctt     2880

tcagatactg aacggcagga cttccaccag tgggcgatcc atgagcactt tctccctgag     2940

tcctcggctt cagggggctg tgacggagac ctgcaggctg cgtgtaccat tcttgtcaac     3000

gcactgatgg atttccacca aagctcaagg agttatgacc actcagaaaa ttctgatttg     3060

gtctttggtg gccgcacagg aaatgaggat attatttcca gattgcagga gatggtagct     3120

gacctggagc tgcagcaaga cctcatagtg cctctcggcc acaccccttc ccaggagcac     3180

ttcctctttg agattttccg cagacggctc caggctctga caagcgggtg gagcgtggct     3240

gccagccttc agagacagag ggagctgcta atgtacaaac ggatcctcct ccgcctgcct     3300

tcgtctgtcc tctgcggcag cagcttccag gcagaacagc ccatcactgc cagatgcgag     3360

cagttcttcc acttggtcaa ctctgagatg agaaacttct gctcccacgg aggtgccctg     3420

acacaggaca tcactgccca cttcttcagg ggcctcctga acgcctgtct gcggagcaga     3480

gacccctccc tgatggtcga cttcatactg gccaagtgcc agacgaaatg ccccttaatt     3540

ttgacctctg ctctggtgtg gtggccgagc ctggagcctg tgctgctctg ccggtggagg     3600

agacactgcc agagcccgct gccccgggaa ctgcagaagc tacaagaagg ccggcagttt     3660

gccagcgatt tcctctcccc tgaggctgcc tccccagcac ccaacccgga ctggctctca     3720

gctgctgcac tgcactttgc gattcaacaa gtcagggaag aaaacatcag gaagcagcta     3780

aagaagctgg actgcgagag agaggagcta ttggttttcc ttttcttctt ctccttgatg     3840

ggcctgctgt cgtcacatct gacctcaaat agcaccacag acctgccaaa ggctttccac     3900

gtttgtgcag caatcctcga gtgtttagag aagaggaaga tatcctggct ggcactcttt     3960

cagttgacag agagtgacct caggctgggg cggctcctcc tccgtgtggc cccggatcag     4020

cacaccaggc tgctgccttt cgctttttac agtcttctct cctacttcca tgaagacgcg     4080

gccatcaggg aagaggcctt cctgcatgtt gctgtggaca tgtacttgaa gctggtccag     4140

ctcttcgtgg ctggggatac aagcacagtt tcacctccag ctggcaggag cctggagctc     4200

aagggtcagg gcaaccccgt ggaactgata acaaaagctc gtctttttct gctgcagtta     4260

atacctcggt gcccgaaaaa gagcttctca cacgtggcag agctgctggc tgatcgtggg     4320

gactgcgacc cagaggtgag cgccgccctc cagagcagac agcaggctgc ccctgacgct     4380

gacctgtccc aggagcctca tctcttctga cgggacctgc cactgcacac cagcccagct     4440

cccgtgtaaa taatttatta caagcataac atggagctct tgttgcacta aaaagtggat     4500

tacaaatctc ctcgactgct ttagtgggga aaggaatcaa ttatttatga actgtccggc     4560

cccgagtcac tcagcgtttg cgggaaaata aaccactggt cccagagcag aggaaggcta     4620

cttgagccgg acaccaagcc cgcctccagc accaagggcg ggcagcaccc tccgaccctc     4680

ccatgcgggt gcacacgaag ggtgaggctg acacagccac tgcggagtcc aggctgctag     4740

aggtgctcat cctcactgcc gtcctcaggt gggttcgggc ttcaccgcct ggccctctgt     4800

ggtcacagag gggctcggtg gcccaggtgg tggttccgcc tccaggggca gggccttgtc     4860

ctgggtctgt gtcagcgggt gcaccatgga catgtgtaca ttgaggttgt gggccttctc     4920

aaaccgccgg ccacactggt cacaggcaaa gtccagctca gtctcagcct tgtgtttggt     4980

catgtggtac ttgagggatg cccgctgcct gcactggaac ccacagacct cacacctggg     5040

ggacagaggc agataagaag gtgcgagggc cacagccctg ggagggggtc ctgactcaca     5100

cttactgcaa aggcttggct cccgaatgtc gcatttggtg gacgagaagg tgcttccgct     5160

gcttgaaggt ttgtccacat tcgtcacaga tatagttccg cacctctgag aggggagagt     5220

ccagtgagtc caggcccctg atgctccaac ctcccggggg gacgacgatg acaatgtgaa     5280

accatcacag ctgggaagac atttctgcac atggttcacc atgcagtggg cccaagcaag     5340

gggcctatga gggcctcgtt tattaagatc tttaaactgc tttatacact gtcacgtggc     5400

ttcatcagct gtgtgcattt caggatggtt tttaaagaaa cctcagaaag ctatttcctt     5460


<210>  70
<211>  4555
<212>  DNA
<213>  Homo sapiens

<400>  70
aatcggaata ggcaagcttc cggcgggaag tgagccaggg cttggcgcgg cggccgtggt       60

tgcggcgcgg gaagtttgga tcctggttcc gtccgctagg agtctgcgtg cgaggattat      120

ggctgctgtt cctcaaaata atctacagga gcaactagaa cgtcactcag ccagaacact      180

taataataaa ttaagtcttt caaaaccaaa attttcaggt ttcactttta aaaagaaaac      240

atcttcagat aacaatgtat ctgtaactaa tgtgtcagta gcaaaaacac ctgtattaag      300

aaataaagat gttaatgtta ccgaagactt ttccttcagt gaacctctac ccaacaccac      360

aaatcagcaa agggtcaagg acttctttaa aaatgctcca gcaggacagg aaacacagag      420

aggtggatca aaatcattat tgccagattt cttgcagact ccgaaggaag ttgtatgcac      480

tacccaaaac acaccaactg taaagaaatc ccgggatact gctctcaaga aattagaatt      540

tagttcttca ccagattctt taagtaccat caatgattgg gatgatatgg atgactttga      600

tacttctgag acttcaaaat catttgttac accaccccaa agtcactttg taagagtaag      660

cactgctcag aaatcaaaaa agggtaagag aaactttttt aaagcacagc tttatacaac      720

aaacacagta aagactgatt tgcctccacc ctcctctgaa agcgagcaaa tagatttgac      780

tgaggaacag aaggatgact cagaatggtt aagcagcgat gtgatttgca tcgatgatgg      840

ccccattgct gaagtgcata taaatgaaga tgctcaggaa agtgactctc tgaaaactca      900

tttggaagat gaaagagata atagcgaaaa gaagaagaat ttggaagaag ctgaattaca      960

ttcaactgag aaagttccat gtattgaatt tgatgatgat gattatgata cggattttgt     1020

tccaccttct ccagaagaaa ttatttctgc ttcttcttcc tcttcaaaat gccttagtac     1080

gttaaaggac cttgacacct ctgacagaaa agaggatgtt cttagcacat caaaagatct     1140

tttgtcaaaa cctgagaaaa tgagtatgca ggagctgaat ccagaaacca gcacagactg     1200

tgacgctaga cagataagtt tacagcagca gcttattcat gtgatggagc acatctgtaa     1260

attaattgat actattcctg atgataaact gaaacttttg gattgtggga acgaactgct     1320

tcagcagcgg aacataagaa ggaaacttct aacggaagta gattttaata aaagtgatgc     1380

cagtcttctt ggctcattgt ggagatacag gcctgattca cttgatggcc ctatggaggg     1440

tgattcctgc cctacaggga attctatgaa ggagttaaat ttttcacacc ttccctcaaa     1500

ttctgtttct cctggggact gtttactgac taccacccta ggaaagacag gattctctgc     1560

caccaggaag aatctttttg aaaggccttt attcaatacc catttacaga agtcctttgt     1620

aagtagcaac tgggctgaaa caccaagact aggaaaaaaa aatgaaagct cttatttccc     1680

aggaaatgtt ctcacaagca ctgctgtgaa agatcagaat aaacatactg cttcaataaa     1740

tgacttagaa agagaaaccc aaccttccta tgatattgat aattttgaca tagatgactt     1800

tgatgatgat gatgactggg aagacataat gcataattta gcagccagca aatcttccac     1860

agctgcctat caacccatca aggaaggtcg gccaattaaa tcagtatcag aaagactttc     1920

ctcagccaag acagactgtc ttccagtgtc atctactgct caaaatataa acttctcaga     1980

gtcaattcag aattatactg acaagtcagc acaaaattta gcatccagaa atctgaaaca     2040

tgagcgtttc caaagtctta gttttcctca tacaaaggaa atgatgaaga tttttcataa     2100

aaaatttggc ctgcataatt ttagaactaa tcagctagag gcgatcaatg ctgcactgct     2160

tggtgaagac tgttttatcc tgatgccgac tggaggtggt aagagtttgt gttaccagct     2220

ccctgcctgt gtttctcctg gggtcactgt tgtcatttct cccttgagat cacttatcgt     2280

agatcaagtc caaaagctga cttccttgga tattccagct acatatctga caggtgataa     2340

gactgactca gaagctacaa atatttacct ccagttatca aaaaaagacc caatcataaa     2400

acttctatat gtcactccag aaaagatctg tgcaagtaac agactcattt ctactctgga     2460

gaatctctat gagaggaagc tcttggcacg ttttgttatt gatgaagcac attgtgtcag     2520

tcagtgggga catgattttc gtcaagatta caaaagaatg aatatgcttc gccagaagtt     2580

tccttctgtt ccggtgatgg ctcttacggc cacagctaat cccagggtac agaaggacat     2640

cctgactcag ctgaagattc tcagacctca ggtgtttagc atgagcttta acagacataa     2700

tctgaaatac tatgtattac cgaaaaagcc taaaaaggtg gcatttgatt gcctagaatg     2760

gatcagaaag caccacccat atgattcagg gataatttac tgcctctcca ggcgagaatg     2820

tgacaccatg gctgacacgt tacagagaga tgggctcgct gctcttgctt accatgctgg     2880

cctcagtgat tctgccagag atgaagtgca gcagaagtgg attaatcagg atggctgtca     2940

ggttatctgt gctacaattg catttggaat ggggattgac aaaccggacg tgcgatttgt     3000

gattcatgca tctctcccta aatctgtgga gggttactac caagaatctg gcagagctgg     3060

aagagatggg gaaatatctc actgcctgct tttctatacc tatcatgatg tgaccagact     3120

gaaaagactt ataatgatgg aaaaagatgg aaaccatcat acaagagaaa ctcacttcaa     3180

taatttgtat agcatggtac attactgtga aaatataacg gaatgcagga gaatacagct     3240

tttggcctac tttggtgaaa atggatttaa tcctgatttt tgtaagaaac acccagatgt     3300

ttcttgtgat aattgctgta aaacaaagga ttataaaaca agagatgtga ctgacgatgt     3360

gaaaagtatt gtaagatttg ttcaagaaca tagttcatca caaggaatga gaaatataaa     3420

acatgtaggt ccttctggaa gatttactat gaatatgctg gtcgacattt tcttggggag     3480

taagagtgca aaaatccagt caggtatatt tggaaaagga tctgcttatt cacgacacaa     3540

tgccgaaaga ctttttaaaa agctgatact tgacaagatt ttggatgaag acttatatat     3600

caatgccaat gaccaggcga tcgcttatgt gatgctcgga aataaagccc aaactgtact     3660

aaatggcaat ttaaaggtag actttatgga aacagaaaat tccagcagtg tgaaaaaaca     3720

aaaagcgtta gtagcaaaag tgtctcagag ggaagagatg gttaaaaaat gtcttggaga     3780

acttacagaa gtctgcaaat ctctggggaa agtttttggt gtccattact tcaatatttt     3840

taataccgtc actctcaaga agcttgcaga atctttatct tctgatcctg aggttttgct     3900

tcaaattgat ggtgttactg aagacaaact ggaaaaatat ggtgcggaag tgatttcagt     3960

attacagaaa tactctgaat ggacatcgcc agctgaagac agttccccag ggataagcct     4020

gtccagcagc agaggccccg gaagaagtgc cgctgaggag ctcgacgagg aaatacccgt     4080

atcttcccac tactttgcaa gtaaaaccag aaatgaaagg aagaggaaaa agatgccagc     4140

ctcccaaagg tctaagagga gaaaaactgc ttccagtggt tccaaggcaa agggggggtc     4200

tgccacatgt agaaagatat cttccaaaac gaaatcctcc agcatcattg gatccagttc     4260

agcctcacat acttctcaag cgacatcagg agccaatagc aaattgggga ttatggctcc     4320

accgaagcct ataaatagac cgtttcttaa gccttcatat gcattctcat aacaaccgaa     4380

tctcaatgta catagaccct ctttcttgtt tgtcagcatc tgaccatctg tgactataaa     4440

gctgttattc ttgttatacc atttgaagtt tttactcgtc tctattaata tttaaataaa     4500

tgctgggggg tgatagttct tctttttaaa ataaacattt tcttttgaat aagca          4555


<210>  71
<211>  2264
<212>  DNA
<213>  Homo sapiens

<400>  71
cttttgaagt taacaaaaat tgagtccctg gctgggaggt cccccgagtg ttccgctgtg       60

ggctggaggt ggcgtttctg tcgtgattta tgtggagtgg ttcaaaacag aagttaatca      120

ctcgggaagc ggacgggagg ggcggcgcta ctgcgcatgc ccgggagccg cctggagttt      180

ggaactccac attctttcag acccggcccg ctgcggggcg ttcctggggg gtagcctcaa      240

ggccagcggg gttccttcgg ctgcgtttct gtgggaggcc ctgaaacgcg cggagcttcc      300

ctctgcctcc aggctttccc agcgagagtg aaattaaact tgaaactcgg atcaactggc      360

agtcgttgtt ggtagaacgc cctaaggacc cctccccgcg ggacggaggg aggactcggg      420

acagggaatt ggccctggga gaaaacgcgc ggggggcgtc cgagacgccc cgtgaaagcc      480

gtgccgaccc ttgggaggac tgacaggtct agagacacgc gctgtctgtt gtggtgggcc      540

tcccgggaat aagtgagggg ctctgtgttt cgaggatggt tctagcgcag agccgggtgt      600

ctgccggggt gggctccccg cattgttcgg gctccggcgg gggcggctct gattcctttc      660

catggcccgc ctcccacccc gggaatcccc agtgctcctt ttccacggct tttctggcgt      720

ccccccgact ctcccgcggc actttggcct accttccccc agcgccgtgg tcctccctgg      780

cgaccccctc tgcgctcctg gggtcctcct gcgccccccc tcctccaccg gcgcgctgcc      840

cacagccgcg tgccctctcc ccggagctgg ggaccaaggc tgggccccgc cggccgcatc      900

ggtgggaact tccgcggtcc ccatcccagg gcgcacaggg tccagctcct cggcgccgac      960

tcctggaaac aatgaaaggt attgttgcag catctggcag tgagactgag gatgaggaca     1020

gcatggacat tcccttggac ctttcttcat ccgctggctc aggcaagaga aggagaaggg     1080

gcaacctacc caaggagtct gtgcagattc ttcgggattg gctgtatgag caccgttaca     1140

atgcctatcc ttcagagcaa gaaaaagcgt tgctgtccca gcaaacacac ctgtctacgc     1200

tacaggtctg taactggttc atcaacgccc gccgcaggct cctccctgac atgctgagaa     1260

aggatggcaa agatccaaat cagttcacaa tttcccgccg tggggccaag atttctgaaa     1320

cgagctctgt ggagtccgtg atgggcatca aaaacttcat gccagctcta gaggagaccc     1380

catttcattc ctgtacagct gggccaaacc caaccctagg gaggccactg tctcctaagc     1440

cgtcatcccc gggatcagtt ttggctcgtc catcagtgat ctgccatacc actgtgactg     1500

cattgaaaga tgtccctttc tctctctgcc agtcggtcgg tgtgggacaa aacacagata     1560

tacagcagat agcggccaaa aacttcacag acacctctct catgtaccca gaggacactt     1620

gtaaatctgg accaagtacg aatacacaga gtggtctttt caacactcct ccccctactc     1680

caccggacct caaccaggac ttcagtggat ttcagcttct agtggatgtt gcactcaaac     1740

gggctgcaga gatggagctt caggcaaaac ttacagctta acccattttc aagcaaaaca     1800

gttctcagaa atgtcatgat tgccggggtg aaggcaagag atgaattgca ttattttata     1860

tattttttat taatatttgc acatgggatt gctaaaacag cttcctgtta ctgagatgtc     1920

ttcaatggaa tacagtcatt ccaagaacta taaacttaaa gctactgtag aaacaaaggg     1980

ttttcttttt taaatgtttc ttggtagatt attcataatg tgagatggtt cccaatatca     2040

tgtgattttt tttttcctcc ccttcccttt ttttgttatt ttttcagact gtgcaatact     2100

tagagaacct atagcatctt ctcattccca tgtggaacag gatgcccaca tactgtctaa     2160

ttaataaatt ttccattttt tttcaaacaa gtatgaatct agttggttga tgcctttttt     2220

ttcatgacat aataaagtat tttctttaaa aaaaaaaaaa aaaa                      2264


<210>  72
<211>  6055
<212>  DNA
<213>  Homo sapiens

<400>  72
actgagtccc gggaccccgg gagagcggtc aatgtgtggt cgctgcgttt cctctgcctg       60

cgccgggcat cacttgcgcg ccgcagaaag tccgtctggc agcctggata tcctctccta      120

ccggcacccg cagacgcccc tgcagccgcg gtcggcgccc gggctcccta gccctgtgcg      180

ctcaactgtc ctgcgctgcg gggtgccgcg agttccacct ccgcgcctcc ttctctagac      240

aggcgctggg agaaagaacc ggctcccgag ttctgggcat ttcgcccggc tcgaggtgca      300

ggatgcagag caaggtgctg ctggccgtcg ccctgtggct ctgcgtggag acccgggccg      360

cctctgtggg tttgcctagt gtttctcttg atctgcccag gctcagcata caaaaagaca      420

tacttacaat taaggctaat acaactcttc aaattacttg caggggacag agggacttgg      480

actggctttg gcccaataat cagagtggca gtgagcaaag ggtggaggtg actgagtgca      540

gcgatggcct cttctgtaag acactcacaa ttccaaaagt gatcggaaat gacactggag      600

cctacaagtg cttctaccgg gaaactgact tggcctcggt catttatgtc tatgttcaag      660

attacagatc tccatttatt gcttctgtta gtgaccaaca tggagtcgtg tacattactg      720

agaacaaaaa caaaactgtg gtgattccat gtctcgggtc catttcaaat ctcaacgtgt      780

cactttgtgc aagataccca gaaaagagat ttgttcctga tggtaacaga atttcctggg      840

acagcaagaa gggctttact attcccagct acatgatcag ctatgctggc atggtcttct      900

gtgaagcaaa aattaatgat gaaagttacc agtctattat gtacatagtt gtcgttgtag      960

ggtataggat ttatgatgtg gttctgagtc cgtctcatgg aattgaacta tctgttggag     1020

aaaagcttgt cttaaattgt acagcaagaa ctgaactaaa tgtggggatt gacttcaact     1080

gggaataccc ttcttcgaag catcagcata agaaacttgt aaaccgagac ctaaaaaccc     1140

agtctgggag tgagatgaag aaatttttga gcaccttaac tatagatggt gtaacccgga     1200

gtgaccaagg attgtacacc tgtgcagcat ccagtgggct gatgaccaag aagaacagca     1260

catttgtcag ggtccatgaa aaaccttttg ttgcttttgg aagtggcatg gaatctctgg     1320

tggaagccac ggtgggggag cgtgtcagaa tccctgcgaa gtaccttggt tacccacccc     1380

cagaaataaa atggtataaa aatggaatac cccttgagtc caatcacaca attaaagcgg     1440

ggcatgtact gacgattatg gaagtgagtg aaagagacac aggaaattac actgtcatcc     1500

ttaccaatcc catttcaaag gagaagcaga gccatgtggt ctctctggtt gtgtatgtcc     1560

caccccagat tggtgagaaa tctctaatct ctcctgtgga ttcctaccag tacggcacca     1620

ctcaaacgct gacatgtacg gtctatgcca ttcctccccc gcatcacatc cactggtatt     1680

ggcagttgga ggaagagtgc gccaacgagc ccagccaagc tgtctcagtg acaaacccat     1740

acccttgtga agaatggaga agtgtggagg acttccaggg aggaaataaa attgaagtta     1800

ataaaaatca atttgctcta attgaaggaa aaaacaaaac tgtaagtacc cttgttatcc     1860

aagcggcaaa tgtgtcagct ttgtacaaat gtgaagcggt caacaaagtc gggagaggag     1920

agagggtgat ctccttccac gtgaccaggg gtcctgaaat tactttgcaa cctgacatgc     1980

agcccactga gcaggagagc gtgtctttgt ggtgcactgc agacagatct acgtttgaga     2040

acctcacatg gtacaagctt ggcccacagc ctctgccaat ccatgtggga gagttgccca     2100

cacctgtttg caagaacttg gatactcttt ggaaattgaa tgccaccatg ttctctaata     2160

gcacaaatga cattttgatc atggagctta agaatgcatc cttgcaggac caaggagact     2220

atgtctgcct tgctcaagac aggaagacca agaaaagaca ttgcgtggtc aggcagctca     2280

cagtcctaga gcgtgtggca cccacgatca caggaaacct ggagaatcag acgacaagta     2340

ttggggaaag catcgaagtc tcatgcacgg catctgggaa tccccctcca cagatcatgt     2400

ggtttaaaga taatgagacc cttgtagaag actcaggcat tgtattgaag gatgggaacc     2460

ggaacctcac tatccgcaga gtgaggaagg aggacgaagg cctctacacc tgccaggcat     2520

gcagtgttct tggctgtgca aaagtggagg catttttcat aatagaaggt gcccaggaaa     2580

agacgaactt ggaaatcatt attctagtag gcacggcggt gattgccatg ttcttctggc     2640

tacttcttgt catcatccta cggaccgtta agcgggccaa tggaggggaa ctgaagacag     2700

gctacttgtc catcgtcatg gatccagatg aactcccatt ggatgaacat tgtgaacgac     2760

tgccttatga tgccagcaaa tgggaattcc ccagagaccg gctgaagcta ggtaagcctc     2820

ttggccgtgg tgcctttggc caagtgattg aagcagatgc ctttggaatt gacaagacag     2880

caacttgcag gacagtagca gtcaaaatgt tgaaagaagg agcaacacac agtgagcatc     2940

gagctctcat gtctgaactc aagatcctca ttcatattgg tcaccatctc aatgtggtca     3000

accttctagg tgcctgtacc aagccaggag ggccactcat ggtgattgtg gaattctgca     3060

aatttggaaa cctgtccact tacctgagga gcaagagaaa tgaatttgtc ccctacaaga     3120

ccaaaggggc acgattccgt caagggaaag actacgttgg agcaatccct gtggatctga     3180

aacggcgctt ggacagcatc accagtagcc agagctcagc cagctctgga tttgtggagg     3240

agaagtccct cagtgatgta gaagaagagg aagctcctga agatctgtat aaggacttcc     3300

tgaccttgga gcatctcatc tgttacagct tccaagtggc taagggcatg gagttcttgg     3360

catcgcgaaa gtgtatccac agggacctgg cggcacgaaa tatcctctta tcggagaaga     3420

acgtggttaa aatctgtgac tttggcttgg cccgggatat ttataaagat ccagattatg     3480

tcagaaaagg agatgctcgc ctccctttga aatggatggc cccagaaaca atttttgaca     3540

gagtgtacac aatccagagt gacgtctggt cttttggtgt tttgctgtgg gaaatatttt     3600

ccttaggtgc ttctccatat cctggggtaa agattgatga agaattttgt aggcgattga     3660

aagaaggaac tagaatgagg gcccctgatt atactacacc agaaatgtac cagaccatgc     3720

tggactgctg gcacggggag cccagtcaga gacccacgtt ttcagagttg gtggaacatt     3780

tgggaaatct cttgcaagct aatgctcagc aggatggcaa agactacatt gttcttccga     3840

tatcagagac tttgagcatg gaagaggatt ctggactctc tctgcctacc tcacctgttt     3900

cctgtatgga ggaggaggaa gtatgtgacc ccaaattcca ttatgacaac acagcaggaa     3960

tcagtcagta tctgcagaac agtaagcgaa agagccggcc tgtgagtgta aaaacatttg     4020

aagatatccc gttagaagaa ccagaagtaa aagtaatccc agatgacaac cagacggaca     4080

gtggtatggt tcttgcctca gaagagctga aaactttgga agacagaacc aaattatctc     4140

catcttttgg tggaatggtg cccagcaaaa gcagggagtc tgtggcatct gaaggctcaa     4200

accagacaag cggctaccag tccggatatc actccgatga cacagacacc accgtgtact     4260

ccagtgagga agcagaactt ttaaagctga tagagattgg agtgcaaacc ggtagcacag     4320

cccagattct ccagcctgac tcggggacca cactgagctc tcctcctgtt taaaaggaag     4380

catccacacc cccaactcct ggacatcaca tgagaggtgc tgctcagatt ttcaagtgtt     4440

gttctttcca ccagcaggaa gtagccgcat ttgattttca tttcgacaac agaaaaagga     4500

cctcggactg cagggagcca gtcttctagg catatcctgg aagaggcttg tgacccaaga     4560

atgtgtctgt gtcttctccc agtgttgacc tgatcctctt tttcattcat ttaaaaagca     4620

tttatcatgc cccctgctgc gggtctcacc atgggtttag aacaaagacg ttcaagaaat     4680

ggccccatcc tcaaagaagt agcagtacct ggggagctga cacttctgta aaactagaag     4740

ataaaccagg caatgtaagt gttcgaggtg ttgaagatgg gaaggatttg cagggctgag     4800

tctatccaag aggctttgtt taggacgtgg gtcccaagcc aagccttaag tgtggaattc     4860

ggattgatag aaaggaagac taacgttacc ttgctttgga gagtactgga gcctgcaaat     4920

gcattgtgtt tgctctggtg gaggtgggca tggggtctgt tctgaaatgt aaagggttca     4980

gacggggttt ctggttttag aaggttgcgt gttcttcgag ttgggctaaa gtagagttcg     5040

ttgtgctgtt tctgactcct aatgagagtt ccttccagac cgttacgtgt ctcctggcca     5100

agccccagga aggaaatgat gcagctctgg ctccttgtct cccaggctga tcctttattc     5160

agaataccac aaagaaagga cattcagctc aaggctccct gccgtgttga agagttctga     5220

ctgcacaaac cagcttctgg tttcttctgg aatgaatacc ctcatatctg tcctgatgtg     5280

atatgtctga gactgaatgc gggaggttca atgtgaagct gtgtgtggtg tcaaagtttc     5340

aggaaggatt ttaccctttt gttcttcccc ctgtccccaa cccactctca ccccgcaacc     5400

catcagtatt ttagttattt ggcctctact ccagtaaacc tgattgggtt tgttcactct     5460

ctgaatgatt attagccaga cttcaaaatt attttatagc ccaaattata acatctattg     5520

tattatttag acttttaaca tatagagcta tttctactga tttttgccct tgttctgtcc     5580

tttttttcaa aaaagaaaat gtgttttttg tttggtacca tagtgtgaaa tgctgggaac     5640

aatgactata agacatgcta tggcacatat atttatagtc tgtttatgta gaaacaaatg     5700

taatatatta aagccttata tataatgaac tttgtactat tcacattttg tatcagtatt     5760

atgtagcata acaaaggtca taatgctttc agcaattgat gtcattttat taaagaacat     5820

tgaaaaactt gaaggaatcc ctttgcaagg ttgcattact gtacccatca tttctaaaat     5880

ggaagagggg gtggctgggc acagtggccg acacctaaaa acccagcact ttggggggcc     5940

aaggtgggag gatcgcttga gcccaggagt tcaagaccag tctggccaac atggtcagat     6000

tccatctcaa agaaaaaagg taaaaataaa ataaaatgga gaagaaggaa tcaga          6055


<210>  73
<211>  3814
<212>  DNA
<213>  Homo sapiens

<400>  73
agctcggtgc acggcgcgct gattggctgg atccgccatg cggagcggct aggtggtgca       60

cgggaaacgc gggcgtaggt gaccggcggc tttctcagtt ttggtggaga cgggcgcatg      120

tgggcgcttt gctcgctgct gcggtccgcg gccggacgca ccatgtcgca gggacgcacc      180

atatcgcagg cacccgcccg ccgcgagcgg ccgcgcaagg acccgctgcg gcacctgcgc      240

acgcgagaga agcgcggacc gtcggggtgc tccggcggcc caaacaccgt gtacctgcag      300

gtggtggcag cgggtagccg ggactcgggc gccgcgctct acgtcttctc cgagttcaac      360

cggtatctct tcaactgtgg agaaggcgtt cagagactca tgcaggagca caagttaaag      420

gttgctcgcc tggacaacat attcctgaca cgaatgcact ggtctaatgt tgggggctta      480

agtggaatga ttcttacttt aaaggaaacc gggcttccaa agtgtgtact ttctggacct      540

ccacaactgg aaaaatacct cgaagcaatc aaaatatttt ctggtccatt gaaaggaata      600

gaactggctg tgcggcccca ctctgcccca gaatacgagg atgaaaccat gacagtttac      660

cagatcccca tacacagtga acagaggagg ggaaagcacc aaccatggca gagtccagaa      720

aggcctctca gcaggctcag tccagagcga tcttcagact ccgagtcgaa tgaaaatgag      780

ccacaccttc cacatggtgt tagccagaga agaggggtca gggactcttc cctggtcgta      840

gctttcatct gtaagcttca cttaaagaga ggaaacttct tggtgctcaa agcaaaggag      900

atgggcctcc cagttgggac agctgccatc gctcccatca ttgctgctgt caaggacggg      960

aaaagcatca ctcatgaagg aagagagatt ttggctgaag agctgtgtac tcctccagat     1020

cctggtgctg cttttgtggt ggtagaatgt ccagatgaaa gcttcattca acccatctgt     1080

gagaatgcca cctttcagag gtaccaagga aaggcagatg cccccgtggc cttggtggtt     1140

cacatggccc cagcatctgt gcttgtggac agcaggtacc agcagtggat ggagaggttt     1200

gggcctgaca cccagcactt ggtcctgaat gagaactgtg cctcagttca caaccttcgc     1260

agccacaaga ttcaaaccca gctcaacctc atccacccgg acatcttccc cctgctcacc     1320

agtttccgct gtaagaagga gggccccacc ctcagtgtgc ccatggttca gggtgaatgc     1380

ctcctcaagt accagctccg tcccaggagg gagtggcaga gggatgccat tattacttgc     1440

aatcctgagg aattcatagt tgaggcgctg cagcttccca acttccagca gagcgtgcag     1500

gagtacagga ggagtgcgca ggacggccca gccccagcag agaaaagaag tcagtaccca     1560

gaaatcatct tccttggaac agggtctgcc atcccgatga agattcgaaa tgtcagtgcc     1620

acacttgtca acataagccc cgacacgtct ctgctactgg actgtggtga gggcacattt     1680

gggcagctgt gccgtcatta cggagaccag gtggacaggg tcctgggcac cctggctgct     1740

gtgtttgtgt cccacctgca cgcagatcac cacacgggct tgccaagtat cttgctgcag     1800

agagaacgcg ccttggcatc tttgggaaag ccgcttcacc ctttgctggt ggttgccccc     1860

aaccagctca aagcctggct ccagcagtac cacaaccagt gccaggaggt cctgcaccac     1920

atcagtatga ttcctgccaa atgccttcag gaaggggctg agatctccag tcctgcagtg     1980

gaaagattga tcagttcgct gttgcgaaca tgtgatttgg aagagtttca gacctgtctg     2040

gtgcggcact gcaagcatgc gtttggctgt gcgctggtgc acacctctgg ctggaaagtg     2100

gtctattccg gggacaccat gccctgcgag gctctggtcc ggatggggaa agatgccacc     2160

ctcctgatac atgaagccac cctggaagat ggtttggaag aggaagcagt ggaaaagaca     2220

cacagcacaa cgtcccaagc catcagcgtg gggatgcgga tgaacgcgga gttcattatg     2280

ctgaaccact tcagccagcg ctatgccaag gtccccctct tcagccccaa cttcagcgag     2340

aaagtgggag ttgcctttga ccacatgaag gtctgctttg gagactttcc aacaatgccc     2400

aagctgattc ccccactgaa agccctgttt gctggcgaca tcgaggagat ggaggagcgc     2460

agggagaagc gggagctgcg gcaggtgcgg gcggccctcc tgtccaggga gctggcaggc     2520

ggcctggagg atggggagcc tcagcagaag cgggcccaca cagaggagcc acaggccaag     2580

aaggtcagag cccagtgaag atctgggaga ccctgaactc agaaggctgt gtgtcttctg     2640

ccccacgcac gcacccgtat ctgccctcct tgctggtaga agctgaagag cacggtcccc     2700

caggaggcag ctcaggatag gtggtatgga gctgtgccga ggcttgggct cccacataag     2760

cactagtcta tagatgcctc ttaggactgg tgcctggcac agccgcgggc caggaggctg     2820

ccacacggaa gcaagcagat gaactaattt catttcaagg cagtttttaa agaagtcttg     2880

gaaacagacg gcggcacctt tcctctaatc cagcaaagtg attccctgca caccagagac     2940

aagcagagta acaggatcag tgggtctaag tgtccgagac ttaacgaaaa tagtatttca     3000

gctgcaataa agattgagtt tgcaattgtg agttcttttg cttcctcctg ctgctgctac     3060

agagcagggt ctgctgtgca ccaccttgga gaaggctctc tgtgctgtag tgtggcagct     3120

gcctggtacc cgggtggctt ggaagaagtc agctcccgtc gtagtgagca cctctggaac     3180

ctgtcctcag agagccaccc ttattcgcca agtctttttg acaactcgag ctgtgccagc     3240

tcacagcagg gcgtgctttc tctatcaatc aatcaatcaa tcaatcaaat caatcagtga     3300

gagcctggct gggctggtgt cattggtcag ggaaatgcaa gtcttctggt ggttctgggt     3360

aaaagtggag acaatagatt tgctgtgttg ttgcttccat actgagagga gtgaggatca     3420

ctttgccctc gaaggttttg agaaatggca cacggggctg gtttccattg tcctccttgc     3480

gggatttaca gacgtggatt agtgctcgac aaatggagag cattttccaa ggaagtaagt     3540

aagtaaagta agtaagtaag taagtaagtt gaatctagta tttattgtgt atattcccta     3600

cccaggagaa tgtaaaaaga agagctttaa aaactcaaaa gacaagcaag cgagagatca     3660

gccagggacc tggctttaca caggtggtga ccttcaggct ccatcccggt gtgcatttga     3720

gattgacggc catgtccccg caggtttatt aaagcaagaa cagatgccaa gctcagggat     3780

aataaatcta ttttaataac gttaaaaaaa aaaa                                 3814


<210>  74
<211>  6930
<212>  DNA
<213>  Homo sapiens

<400>  74
ctctttctcc ccaggccgaa gcctcgggac ggccctggaa gccgaccatg gcagccgtga       60

ccatgtcggt gcccgggcgg aaggcgcccc ccaggccggg cccagtgccc gaggcggccc      120

agccgttcct gttcacgccc cgcgggccca gcgcgggtgg cgggcctggc tcgggcacct      180

ccccgcaggt ggagtggacg gcccggcgtc tcgtgtgggt gccttcggag cttcacgggt      240

tcgaggcggc ggcgctgcgg gacgaaggcg aggaggaggc ggaggtggag ctggcggaga      300

gcgggaggcg gctgcgactg ccgcgggacc agatccagcg catgaacccg cccaagttca      360

gcaaggccga ggacatggcc gagctgacct gcctcaacga ggcctcggtc ctgcacaacc      420

tccgggagcg gtactactcc ggcctcatct acacgtactc cggccttttc tgtgtggtca      480

tcaacccgta caagcagctt cccatctaca cagaagccat tgtggagatg taccggggca      540

agaagcgcca cgaggtgcca ccccacgtgt acgcagtgac cgagggggcc tatcggagca      600

tgctgcagga tcgtgaggac cagtccattc tctgcactgg agagtctgga gctgggaaga      660

cggaaaacac caagaaggtc atccagtacc tcgcccacgt ggcgtcgtct ccaaagggca      720

ggaaggagcc gggtgtcccc gcctccgtca gcaccgtgtc ttatggtgag ctggagcggc      780

agctgcttca ggccaacccc atcctagagg cctttggcaa tgccaagaca gtgaagaatg      840

acaactcctc ccgattcggc aaattcatcc gcatcaactt tgatgttgcc gggtacatcg      900

tgggcgccaa cattgagacc tacctgctgg agaagtcgcg ggccatccgc caggccaagg      960

acgagtgcag cttccacatc ttctaccagc tgctgggggg cgctggagag cagctcaaag     1020

ccgacctcct cctcgagccc tgctcccact accggttcct gaccaacggg ccgtcatcct     1080

ctcccggcca ggagcgggaa ctcttccagg agacgctgga gtcgctgcgg gtcctgggat     1140

tcagccacga ggaaatcatc tccatgctgc ggatggtctc agcagttctc cagtttggca     1200

acattgcctt gaagagagaa cggaacaccg atcaagccac catgcctgac aacacagctg     1260

cacagaagct ctgccgcctc ttgggactgg gggtgacgga tttctcccga gccttgctca     1320

cccctcgcat caaagttggc cgagactatg tgcagaaagc ccagactaag gaacaggctg     1380

acttcgcgct ggaggccctg gccaaggcca cctacgagcg cctcttccgc tggctggttc     1440

tgcgcctcaa ccgggccttg gaccgcagcc cccgccaagg cgcctccttc ctgggcatcc     1500

tggacatcgc gggctttgag atcttccagc tgaactcctt cgagcagctc tgcatcaact     1560

acaccaacga gaagctgcag cagctcttca accacaccat gttcgtgctg gagcaggagg     1620

agtaccagcg tgagggcatc ccctggacct tcctcgactt tggcctcgac ctgcagccct     1680

gcatcgacct catcgagcgg ccggccaacc cccctggact cctggccctg ctggatgagg     1740

agtgctggtt cccgaaggcc acagacaagt cgtttgtgga gaaggtagcc caggagcagg     1800

gcggccaccc caagttccag cggccgaggc acctgcggga tcaggccgac ttcagtgttc     1860

tccactacgc gggcaaggtc gactacaagg ccaacgagtg gctgatgaaa aacatggacc     1920

ctctgaatga caacgtcgca gccttgctcc accagagcac agaccggctg acggcagaga     1980

tctggaaaga cgaacatggg ggcttccagc agttctcttt ccttggctcc ttcccaccgt     2040

cgcccccagg atctgcagag aggtgcagct ctgctatttc tccgccaggg gtggagggca     2100

tcgtggggct ggaacaggtg agcagcctgg gcgacggccc accaggtggc cgcccccgtc     2160

ggggtatgtt ccggacagtg ggacagctct acaaggagtc cctgagccgc ctcatggcca     2220

cactcagcaa caccaacccc agttttgtcc gctgcattgt ccccaaccac gagaagaggg     2280

ccgggaagct ggagccacgg ctggtgctgg accagcttcg ctgcaacggg gtcctggagg     2340

gcatccgcat ctgtcgccag ggcttcccca accgcatcct cttccaggag ttccggcagc     2400

gatacgagat cctgacaccc aatgccatcc ccaagggctt catggatggg aagcaggcct     2460

gtgaaaagat gatccaggcg ctggaactgg accccaacct ctaccgcgtg ggacagagca     2520

agatcttctt ccgggctggg gtcctggccc agctggaaga ggagcgagac ctgaaggtca     2580

ccgacatcat cgtctccttc caggcagctg cccggggata cctggctcgc agggccttcc     2640

agaagcgcca gcagcagcag agcgccctga gggtgatgca gcggaactgc gcggcctacc     2700

tcaagctgag acactggcag tggtggcggc tgtttaccaa ggtgaagcca ctgctgcagg     2760

tgacgcggca ggatgaggtg ctgcaggcac gggcccagga gctgcagaaa gtgcaggagc     2820

tacagcagca gagcgcccgc gaagttgggg agctccaggg ccgagtggca cagctggaag     2880

aggagcgcgc ccgcctggca gagcaattgc gagcagaggc agaactgtgt gcagaggccg     2940

aggagacgcg ggggaggctg gcagcccgca agcaggagct ggagctggtg gtgtcagagc     3000

tggaggctcg cgtgggcgag gaggaggagt gcagccgtca aatgcaaacc gagaagaaga     3060

ggctgcagca gcacatacag gagctagagg cccaccttga ggctgaggag ggtgcgcggc     3120

agaagctgca gctggagaag gtgacgacag aggcaaaaat gaagaaattt gaagaggacc     3180

tgctgctcct ggaagaccag aattccaagc tgagcaagga gcggaagctg ctggaagatc     3240

gtctggccga gttctcatcc caggcagctg aggaggagga gaaggtcaag agcctcaata     3300

agctacggct caaatatgag gccacaatcg cagacatgga ggaccgccta cggaaggagg     3360

agaagggtcg ccaggagctg gagaagctga agcggaggct ggatggggag agctcagagc     3420

tgcaggagca gatggtggag cagcaacagc gggcagagga gctgcgggcc cagctgggcc     3480

ggaaggagga ggagctgcag gctgccctgg ccagggcaga agacgagggt ggggcccggg     3540

cccagctgct gaaatccctg cgggaggctc aagcagccct ggccgaggcc caggaggacc     3600

tggagtctga gcgtgtggcc aggaccaagg cggagaagca gcgccgggac ctgggcgagg     3660

agctggaggc gctgcggggc gagctggagg acacgctgga ctccaccaac gcacagcagg     3720

agctccggtc caagagggaa caggaggtga cggagctgaa gaagactctg gaggaggaga     3780

ctcgcatcca cgaggcggca gtgcaggagc tgaggcagcg ccacggccag gccctggggg     3840

agctggcgga gcagctggag caggcccgga ggggcaaagg tgcatgggag aagacccggc     3900

tggccctgga ggccgaggtg tccgagctgc gggcagaact gagcagcctg cagactgcac     3960

gtcaggaggg tgagcagcgg aggcgccgcc tggagttaca gctgcaggag gtgcagggcc     4020

gggctggtga tggggagagg gcacgagcgg aggctgctga gaagctgcag cgagcccagg     4080

ctgaactgga gaatgtgtct ggggcgctga acgaggctga gtccaaaacc atccgtctta     4140

gcaaggagct gagcagcaca gaagcccagc tgcacgatgc ccaggagctg ctgcaggagg     4200

agaccagggc gaaattggcc ttggggtccc gggtgcgagc catggaggct gaggcagccg     4260

ggctgcgtga gcagctggag gaggaggcag ctgccaggga acgggcgggc cgtgaactgc     4320

agactgccca ggcccagctt tccgagtggc ggcggcgcca ggaggaggag gcaggggcac     4380

tggaggcagg ggaggaggca cggcgccggg cagcccggga ggccgaggcc ctgacccagc     4440

gcctggcaga aaagacagag accgtggatc ggctggagcg gggccgccgc cggctgcagc     4500

aggagctgga cgacgccacc atggacctgg agcagcagcg gcagcttgtg agcaccctgg     4560

agaagaagca gcgcaagttt gaccagcttc tggcagagga gaaggcagct gtacttcggg     4620

cagtggagga acgtgagcgg gccgaggcag agggccggga gcgtgaggct cgggccctgt     4680

cactgacacg ggcactggag gaggagcagg aggcacgtga ggagctggag cggcagaacc     4740

gggccctgcg ggctgagctg gaggcactgc tgagcagcaa ggatgacgtc ggcaagagcg     4800

tgcatgagct ggaacgagcc tgccgggtag cagaacaggc agccaatgat ctgcgagcac     4860

aggtgacaga actggaggat gagctgacag cggccgagga tgccaagctg cgtctggagg     4920

tgactgtgca ggctctcaag actcagcatg agcgtgacct gcagggccgt gatgaggctg     4980

gtgaagagag gcggaggcag ctggccaagc agctgagaga tgcagaggtg gagcgggatg     5040

aggagcggaa gcagcgcact ctggccgtgg ctgcccgcaa gaagctggag ggagagctgg     5100

aggagctgaa ggctcagatg gcctctgccg gccagggcaa ggaggaggcg gtgaagcagc     5160

ttcgcaagat gcaggcccag atgaaggagc tatggcggga ggtggaggag acacgcacct     5220

cccgggagga gatcttctcc cagaatcggg aaagtgaaaa gcgcctcaag ggcctggagg     5280

ctgaggtgct gcggctgcag gaggaactgg ccgcctcgga ccgtgctcgg cggcaggccc     5340

agcaggaccg ggatgagatg gcagatgagg tggccaatgg taaccttagc aaggcagcca     5400

ttctggagga gaagcgtcag ctggaggggc gcctggggca gttggaggaa gagctggagg     5460

aggagcagag caactcggag ctgctcaatg accgctaccg caagctgctc ctgcaggtag     5520

agtcactgac cacagagctg tcagctgagc gcagtttctc agccaaggca gagagcgggc     5580

ggcagcagct ggaacggcag atccaggagc tacggggacg cctgggtgag gaggatgctg     5640

gggcccgtgc ccgccacaag atgaccattg ctgcccttga gtctaagttg gcccaggctg     5700

aggagcagct agagcaagag accagagagc gcatcctctc tggaaagctg gtgcgcagag     5760

ctgagaagcg gcttaaagag gtggtgctcc aggtggagga ggagcggagg gtggctgacc     5820

agctccggga ccagctggag aagggaaacc ttcgagtcaa gcagctgaag cggcagctgg     5880

aggaggccga ggaggaggca tcccgggctc aggccggccg ccggaggctg cagcgtgagc     5940

tggaagatgt cacagagtcg gccgagtcca tgaaccgtga agtgaccaca ctgaggaacc     6000

ggcttcgacg cggccccctc accttcacca cccgcacggt gcgccaggtc ttccgactag     6060

aggagggcgt ggcatccgac gaggaggcag aggaagcaca gcctgggtct gggccatccc     6120

cggagcctga ggggtcccca ccagcccacc cccagtgacc ctaccctgtc cccagatgca     6180

ctaacagatg gggcccagcc cccttcctcc ctggacccca cgggcccctg tcccaggaac     6240

cccgccctct gacttcttgc cctttggaaa tggtgcagca ctctggcatt tatcaccccc     6300

acctgggtcc cctgcaacct cccatcaaag gatgacccct aaacacagag gagcggggca     6360

ggcagggagg caatgactgg agctaccttg cttgttgggg gactgggtac agttggcaag     6420

ctgtgtttcc atcagctccc tgtcctcctt tcttccctcg ttattgatct atagacatta     6480

ggaagggagt gagacggctc ctccaccatc ctcagccagt gcaacccatt ccctctgctt     6540

ctctctctct ctctctctct ccctccctct ccttccctac cctctcacca tctttcttgg     6600

cctctctgag ggtctctctg tgcatctttt taggaatctc gctctcactc tctacgtagc     6660

cactctcctt cccccatttc tgcgtccacc cctgaactcc tgagcgacag aagccccagg     6720

cctccaccag ccttgaaccc ttgcaaaggg gcaggacaag gggacccctc tcactcctgc     6780

tgctgcccat gctctgccct cccttctggt tgctctgagg gttcggagct tccctctggg     6840

actaaaggag tgtcctttac cctcccagcc tccaggctct ggcagaaata aactccaacc     6900

cgactggacc ataaaaaaaa aaaaaaaaaa                                      6930


<210>  75
<211>  4179
<212>  DNA
<213>  Homo sapiens

<400>  75
acggatttcc gcctccctca cagaaggcag tcactgcaac gtgcgtggcc tcagttgcgt       60

catatccggc ccttgcgatc agggcttgag gaacccgcgc catgaagtgc gtgtttgtta      120

ccgtagggac caccagcttt gacgacctca ttgcgtgtgt gtcggcgccc gacagtctgc      180

aaaaaatcga gagccttggt tacaaccgac ttatcctgca aattggtaga ggaacggtgg      240

tacctgaacc cttcagtact gagtcgttta ctctggatgt ttacaggtac aaggattcct      300

tgaaagaaga cattcagaaa gcagatcttg ttattagtca cgcaggtgca ggaagctgtt      360

tggagactct ggaaaaagga aagccactcg tagtggttat aaacgaaaag ttgatgaaca      420

atcatcagct ggaactggca aagcagctac acaaagaggg tcatctcttc tattgtacct      480

gcagggtcct gacttgtcct gggcaagcca agtccattgc ttctgctcct gggaagtgcc      540

aagattctgc agcgctgact tcaactgcct tttcaggcct agactttggg ctgctttccg      600

gatacctgca taagcaagcc cttgttactg ctacccatcc tacctgcacc ctgctttttc      660

cctcttgcca cgcttttttt cctctccctc ttacccccac cctgtacaaa atgcataaag      720

gatggaaaaa ctactgcagc cagaagtctt tgaatgaggc atcaatggat gaatatttag      780

gcagcttagg gctgtttcga aagctgactg ccaaggatgc ctcttgcctc tttcgggcca      840

tttcggagca gttgttttgc agccaggtcc atcatttgga aatcaggaag gcttgtgtct      900

catatatgag ggaaaatcaa caaacttttg agtcttatgt ggagggatct tttgagaaat      960

acctggaacg gttgggagat cccaaggaaa gtgctggcca gctggaaata agagctcttt     1020

ctctaattta taatcgggat ttcattcttt atcgctttcc tggaaaacct ccaacttatg     1080

tcacagataa tggctatgaa gacaagattc tactctgcta ctcaagtagt ggtcactatg     1140

attctgtgta ctcaaaacaa tttcagtcaa gtgcagctgt ttgtcaggct gtattgtacg     1200

aaattctcta taaagatgtg tttgttgtgg atgaagaaga gttgaagact gcgattaaat     1260

tgtttcgaag tggttctaag aagaacagaa ataatgctgt aactggaagc gaggatgccc     1320

atactgatta caagagttca aatcagaata ggatggaaga gtggggtgcc tgctacaatg     1380

ctgaaaatat accagagggc tacaataaag gaacagaaga aacaaagtct ccagaaaatc     1440

catcaaagat gcccttcccc tataaggtgc tcaaagccct ggatccagaa atctatcgta     1500

atgtagaatt tgatgtttgg ttggacagca gaaaagaact tcaaaaatct gattacatgg     1560

agtatgctgg gagacagtac tatttgggag acaagtgtca ggtttgcttg gaatcagaag     1620

gaagatatta taatgctcat atccaggaag ttggaaatga gaacaattca gtaacagtct     1680

tcattgaaga attggcggaa aagcatgttg ttccactggc taacttaaaa ccagttaccc     1740

aagtgatgtc tgttcctgcc tggaatgcta tgcccagtcg gaaaggaaga ggttaccaga     1800

aaatgcctgg gggttatgtc ccggaaatag ttatatcaga gatggacata aagcaacaga     1860

agaagatgtt caagaaaatt cgagggaaag aagtttacat gactatggct tacggcaagg     1920

gagaccccct cctcccaccc aggctgcagc acagtatgca ttatgggcac gatcctccaa     1980

tgcactactc acagacagct ggcaatgtta tgtctaatga acattttcat cctcagcatc     2040

catctccgag acaaggtcgg ggatatggga tgcccaggaa ttcatctcgg tttataaaca     2100

ggcacaacat gccgggccct aaagttgatt tttacccagg cccaggtaaa aggtgctgcc     2160

agagctatga taacttctct tatagatctc gttcatttag acgtagtcac cgccagatga     2220

gttgtgtgaa taaggagtcc cagtatggat ttaccccagg gaatggacag atgcccaggg     2280

gcttggaaga aactattact ttttatgaag ttgaagaagg ggatgagact gcttatccaa     2340

ctttacctaa tcatggaggt ccctctacaa tggttcctgc tacttcagga tactgtgttg     2400

gaaggcgggg acatagctca ggcaaacaga ctttgaattt agaggagggc aatggccaga     2460

gtgaaaatgg gcgatatcat gaagaatatc tttatcgtgc agagccagac tatgaaactt     2520

caggtgttta tagcacaact gcatctacag caaacttgtc tcttcaggac agaaagtcat     2580

gttctatgtc tcctcaggac acagttacct catacaacta cccccagaag atgatgggaa     2640

atattgcagc agttgcagct tcctgtgcca ataatgttcc agctccagtc ttatctaacg     2700

gtgcagcggc taatcaagct attagtacca cttcagtttc ctcacagaat gctatacagc     2760

ctctctttgt atctccacct acacacggca ggccagtgat tgcctcacca tcctatccat     2820

gccattctgc tattcctcat gctggtgcct ctctaccacc accaccacca ccaccaccac     2880

caccaccacc accaccacct cctcctcctc ctcctcctcc tcctcctcct cctcctgctc     2940

ttgatgtggg agagacttca aacttacaac caccaccacc actaccacct ccaccttatt     3000

cctgtgatcc aagcggcagt gatttgcctc aagatacaaa agttttgcag tactatttca     3060

atctaggatt gcagtgctat taccacagct actggcactc catggtctat gtgccacaga     3120

tgcagcagca gcttcatgta gagaattatc cagtctatac tgagccacct ctggtagatc     3180

aaaccgttcc tcaatgctac agtgaggtga ggagagaaga tggcatacag gcggaagcat     3240

cagcaaatga tacttttccg aatgctgatt cttcatctgt ccctcatgga gcagtctatt     3300

atccagtaat gtcagatccc tatgggcagc cacctttgcc aggttttgac tcctgccttc     3360

cggttgtgcc agattattcc tgtgttcccc cctggcatcc agttggtaca gcatatggtg     3420

gttcttctca aattcatggt gctataaatc ctgggccaat tggctgtatt gctccatctc     3480

ccccagcttc tcattatgta cctcagggta tgtaagatcc agcagtatga agtattcttg     3540

cactgccatt ttcttgctgt ttttgttttt aaaaagtatt ttatgttagt ggttaaatga     3600

tttaggtgat tagtgtttac tattgtattt gtctttaaaa ttattttatc ttttgattta     3660

aaatagtact ttaaaattaa ggggtattat tttgggctgt gactaaggaa attgagatgg     3720

atgtacaact agccccatat tgagcatact tcattgtatt cagctgtttt cctgtcagcc     3780

atttgtcagc tttatattag ctgatggtac caattgataa aatgaatata aagtatttca     3840

ttggttcaaa aatcacacat catattaaac catgcagaat tggagtaact tccacttttt     3900

tctagaaagt aaaaccaaga gcctttgctt ctggataact cacttaatat taaattaaag     3960

agctcttcac gtttcttgag aattatctga agccagttgc attctgtgat atcagttttg     4020

aaggcacatg gttctctgct ttagatttat cccatatgct attgtttaat actggatgta     4080

tgtaagtgtt ttactgcact gtattgaatt ggtgtctttt gcacagttag cagtaaataa     4140

aaattagcat ttaaaattgc caaaaaaaaa aaaaaaaaa                            4179


<210>  76
<211>  3976
<212>  DNA
<213>  Homo sapiens

<400>  76
accaagtgag gaaactgggg gacgctgtgg ggaggggcgt ggggctggat cgcgcagcgg       60

ctgcttcctt taccttcctc ccatggtctc cttccggttc tcgatgcttc tctgagccta      120

agggtttccg ccactcgttc accctccccc cagctcatga tcctcctccc tcccccgccc      180

tcctggtcca atctccgatc tgtttagtaa gaaggtgctg ttccgagaag aaggaaaagg      240

gcttgacacg tattcactcg gccccggacg tgggaagcaa gccgtctggc ttcggcctca      300

catcggtctt gtgctcggga cggcggcgtt ggcggactga tccgcggcgg tgaagaggcg      360

cctgtgtctg gcagagctgg tgtgagacga gacaatcctg ccccgccgcc gggataatca      420

agagttttgg ccggaccttt gagcatacac cgagagagtg aggagccaga cgacaagcac      480

acactatggc gctgaaacgg attaataagg aacttagtga tttggcccgt gaccctccag      540

cacaatgttc tgcaggtcca gttggggatg atatgtttca ttggcaagcc acaattatgg      600

gacctaatga cagcccatat caaggcggtg tattcttttt gacaattcat tttcctacag      660

actacccctt caaaccacct aaggttgcat ttacaacaag aatttatcat ccaaatatta      720

acagtaatgg cagcatttgt ctcgatattc taagatcaca gtggtcgcct gctttaacaa      780

tttctaaagt tcttttatcc atttgttcac tgctatgtga tccaaaccca gatgaccccc      840

tagtgccaga gattgcacgg atctataaaa cagacagaga taagtacaac agaatatctc      900

gggaatggac tcagaagtat gccatgtgat gctaccttaa agtcagaata acctgcatta      960

tagctggaat aaactttaaa ttactgttcc ttttttgatt ttcttatccg gctgctcccc     1020

tatcagacct catctttttt aattttattt tttgtttacc tccctccatt cattcacatg     1080

ctcatctgag aagacttaag ttcttccagc tttggacaat aactgctttt agaaactgta     1140

aagtagttac aagagaacag ttgcccaaga ctcagaattt ttaaaaaaaa aaatggagca     1200

tgtgtattat gtggccaatg tcttcactct aacttggtta tgagactaaa accattcctc     1260

actgctctaa catgctgaag aaatcatctg agggggaggg agatggatgc tcagttgtca     1320

catcaaagga tacagcatta ttctagcagc atccattctt gtttaagcct tccactgtta     1380

gagatttgag gttacatgat atgctttatg ctcataactg atgtggctgg agaattggta     1440

ttgaatttat agcatcagca gaacagaaaa tgtgatgtat tttatgcatg tcaataaagg     1500

aatgacctgt tcttgttcta cagagaatgg aaattggaag tcaaacaccc tttgtattcc     1560

aaaatagggt ctcaaacatt ttgtaatttt catttaaatt gttaggaggc ttggagctat     1620

tagttaatct atcttccaat acactgttta atatagcact gaataaatga tgcaagttgt     1680

caatggatga gtgatcaact aatagctctg ctagtaattg atttattttt cttcaataaa     1740

gttgcataaa ccaatgagtt agctgcctgg attaatcagt atgggaaaca atcttttgta     1800

aatgcaaagc tgttttttgt atatactgtt gggatttgct tcattgtttg acatcaaatg     1860

atgatgtaaa gttcgaaaga gtgaatattt tgccatgttc agttaaagtg cacagtctgt     1920

tacaggttga cacattgctt gacctgattt atgcagaatt aataagctat ttggatagtg     1980

tagctttaat gtgctgcaca tgatactggc agccctagag ttcatagatg gacttttggg     2040

acccagcagt tttgaaatgt gtttatggag tttaagaaat ttattttcca ggtgcagccc     2100

ctgtctaact gaaatttctc ttcaccttgt acacttgaca gctgaaaaaa aacaacatgg     2160

gagtaataat gggtcaaaat ttgcaaaata aagtactgtt ttggtgtggg agttgtcatg     2220

aggctgtgtt gaagtgactt atctatgtgg gatattgagt atccattgaa atggatttgt     2280

tcagccattt acattaatga gcatttaaat gcaacagata tcatttcagg tgacttaaca     2340

tgaatgaata aaagtcaatg ctattggatt gttttttgtt tgacaagtgc tatctgtgcc     2400

actgatttaa cttctgtagt aacaagggca ttaccattct tcacctttcc taattctgat     2460

cccatagttt tacatttttc ctgtttattt tgattttgtt cactgcttta tttcttaaag     2520

ttctagcaca tctgtgactc ctccacttcc acatttttgc actgcttaca cttacgtgca     2580

atcttattcc ttgtctgcac acacatgtgg aaagctagaa ataaatgtta aaacttactt     2640

tttataaaca ttttaatatg tagtttggac atgatttatt gacttaaggt tcttctctaa     2700

actggaagtg aaatgcatgc cttctgaaga tgttctggct ttgttaattc tgtaatcatt     2760

tcattgggga aaaaaccagc tacgcagttt ttccaatgag tgaatttttt cattttgtgt     2820

tttgcttaaa acggctcctt cagggtagat gtcatactgc ataacttttt tggattcaaa     2880

ttatgaatga gaaattagtt aacattctgc tccacaaggt aagaaaaact gctctttggc     2940

tctattttca aaattacttc tgagatgcat atagtctcaa aataacagct ttagtaggca     3000

tatcacttct tgaaagccaa acatgagtgt aagacacttt tatgaaacac ggtggatccc     3060

taactggctt tcaaattgac ctttatagcc ttagacaacc cttaggtatt tacggagatg     3120

acttctttga ttgtcataac aattagtgga tgtgtccagt tctctgtatc tttgacttga     3180

tgctttatac atcatttcat ttgttgcttc taagggaata agccatagag gcttctccag     3240

gtttaaaaga acagtaaagt acctggaaaa ccaacatttt tgaatgtatg gacactggac     3300

atgagatatg tacaatgaaa tcttaaaaga atctaagaat ttgccctctt tgccccactc     3360

cacccagtaa tttgacatta ctagtgccat gtataggacc caactgagta ttagaatcag     3420

ttttgactat gtctttgtat ttcctaaatc ttttaatgca taaaccgaat tagggtccag     3480

ttggcctgtt aatggtaaat ttacatttta aatgactcag tttgtttttc ctgggcgagt     3540

ttgcaatgtg ataatcagat tttttaaaac tgattaattt gctttcttgt gtgggtgtac     3600

tcacatttta aagtatgaac cacagttaac tagtggtctc aggggtagtg aaacactcac     3660

tttttttttt gtttgttttt ttttgtttgt tgaaatggct tagttgaagt atacttaagg     3720

tactgatcat gctgtgttag taatttgggc ggggaggggg gtaactcagc catgttttgt     3780

gttggcataa caaaactgtt aatgattgtt gattacactt ttaagtgaat ttgtctttta     3840

tgaggaaccc agtgcaagtc actaaatatt gtctaatagt gacatctgca taagacttgt     3900

aatagctgaa gttaattgag cttaaaggaa ttgttaccat taaagtctgt gtttaaagac     3960

aaaaaaaaaa aaaaaa                                                     3976


<210>  77
<211>  8434
<212>  DNA
<213>  Homo sapiens

<400>  77
ggaagagttc tagcctgaaa gggaactcgg gcgtcgtcct ggcgtcctct ccggattgcg       60

ccgcaccctc gcttcctgcc agggaggggc tgccgggctt tggcggctcc cgagcatcga      120

gaacggggcc agagcagctt cctgcctgcc ccccgcgacc atagagcgcg ggcccagggc      180

gccgcccgcg ggtgggggac gttcccagga cggaagtggc cgagagagtg tcgaagggag      240

ggcgaggccg gagcccgagg gcgacccgag aagcggcggg gcggcgggcc ggcgggcggg      300

gcgcagagcc aggcagcgca ggtatagcca ggctggagaa aagaagctgc caccatggtt      360

gcactttcac tgaagatcag cattgggaat gtggtgaaga cgatgcagtt tgagccgtct      420

accatggtgt acgacgcctg ccgcatcatt cgtgagcgga tcccagaggc cccagctggt      480

cctcccagcg actttgggct ctttctgtca gatgatgacc ccaaaaaggg tatatggctg      540

gaggctggga aagctttgga ctactacatg ctccgaaatg gggacactat ggagtacagg      600

aagaaacaga gacccctgaa gatccgtatg ctggatggaa ctgtgaagac gatcatggtg      660

gatgactcta agactgtcac tgacatgctc atgaccatct gtgcccgcat tggcatcacc      720

aatcatgatg aatattcatt ggttcgagag ctgatggaag agaaaaagga ggaaataaca      780

gggaccttaa gaaaggacaa gacattgctg cgagatgaaa agaagatgga gaaactaaag      840

cagaaattgc acacagatga tgagttgaac tggctggacc atggtcggac actgagggag      900

cagggtgtag aggagcacga gacgctgctg ctgcggagga agttctttta ctcagaccag      960

aatgtggatt cccgggaccc tgtacagctg aacctcctgt atgtgcaggc acgagatgac     1020

atcctgaatg gctcccaccc tgtctccttt gacaaggcct gtgagtttgc tggcttccaa     1080

tgccagatcc agtttgggcc ccacaatgag cagaagcaca aggctggctt ccttgacctg     1140

aaggacttcc tgcccaagga gtatgtgaag cagaagggag agcgtaagat cttccaggca     1200

cacaagaatt gtgggcagat gagtgagatt gaggccaagg tccgctacgt gaagctagcc     1260

cgttctctca agacttacgg tgtctccttc ttcctggtga aggaaaaaat gaaagggaag     1320

aacaagctag tgcccaggct tctgggcatc accaaggagt gtgtgatgcg agtggatgag     1380

aagaccaagg aagtgatcca ggagtggaac ctcaccaaca tcaaacgctg ggctgcgtct     1440

cccaaaagct tcaccctgga ttttggagat taccaagatg gctattactc agtacagaca     1500

actgaagggg agcagattgc acagctcatt gccggctaca tcgatatcat cctgaagaag     1560

aaaaaaagca aggatcactt tgggctggaa ggagatgagg agtctactat gctggaggac     1620

tcagtgtccc ccaaaaagtc aacagtcctg cagcagcaat acaaccgggt ggggaaagtg     1680

gagcatggct ctgtggccct gcctgccatc atgcgctctg gagcctctgg tcctgagaat     1740

ttccaggtgg gcagcatgcc ccctgcccag cagcagatta ccagcggcca gatgcaccga     1800

ggacacatgc ctcctctgac ttcagcccag caggcactca ctggaaccat taactccagc     1860

atgcaggccg tgcaggctgc ccaggccacc ctggatgact ttgacactct gccgcctctt     1920

ggccaggatg ctgcctctaa ggcctggcgt aaaaacaaga tggatgaatc aaagcatgag     1980

atccactctc aggtagatgc catcacagct ggtactgcgt ctgtggtgaa cctgacagca     2040

ggggaccctg ctgagacaga ctataccgca gtgggctgtg cagtcaccac aatctcctcc     2100

aacctgacgg agatgtcccg tggggtgaag ctgctggctg ccttgctgga ggacgaaggc     2160

ggcagtggtc ggcccctgtt gcaggcagca aagggccttg cgggagcagt gtcagaactg     2220

ctgcgcagtg cccaaccagc cagtgctgag ccccgtcaga acctgctgca agcagctggg     2280

aacgtgggcc aggccagtgg ggagctgttg caacaaattg gggaaagtga tactgacccc     2340

cacttccagg atgcgctaat gcagctcgcc aaagctgtgg caagtgctgc agctgccctg     2400

gtcctcaagg ccaagagtgt ggcccagcgg acagaggact cgggacttca gacccaagtt     2460

attgctgcag caacacagtg tgccctatcc acttcccaac tagtggcctg tactaaggtg     2520

gtggcaccta caatcagctc acctgtctgc caagagcaac tggtggaggc tggacgactg     2580

gtagccaaag ccgtggaggg ctgtgtgtct gcctcccagg cagctacaga ggatgggcaa     2640

ctgttgcgag gggtaggagc agcagccaca gctgtcaccc aggccctaaa tgagctgctg     2700

cagcatgtga aagcccatgc cacaggggct gggcctgctg gccgttatga ccaggctact     2760

gacaccatcc taaccgtcac tgagaacatc tttagctcca tgggtgatgc tggggagatg     2820

gtgcgacagg cccgcatcct ggcccaagcc acatctgacc tggtcaatgc catcaaggct     2880

gatgctgagg gggaaagtga tctggagaac tcccgcaagc tcttaagtgc tgccaagatc     2940

ctagctgatg ccacagccaa gatggtagag gctgccaagg gagcagctgc ccaccctgac     3000

agtgaggagc agcagcagcg gctgcgggag gcagctgagg ggctgcgcat ggccaccaat     3060

gcagctgcgc agaatgccat caagaaaaag ctggtgcagc gcctggagca tgcagccaag     3120

caggctgcag cctcagccac acagaccatc gctgcagctc agcacgcagc ctctaccccc     3180

aaggcctctg ccggccccca gcccctgctg gtgcagagct gcaaggcagt ggcagagcag     3240

attccactgc tggtgcaggg cgtccgagga agccaagccc agcctgacag ccccagcgct     3300

cagcttgccc tcattgctgc cagccagagc ttcctgcagc caggtgggaa gatggtggca     3360

gctgcaaagg cctcagtgcc aacgattcag gaccaggctt cagccatgca gctgagtcag     3420

tgtgccaaga acctgggcac cgcgctggct gaactccgga cggctgccca gaaggctcag     3480

gaagcatgtg gacctttgga gatggattct gcactgagtg tggtacagaa tctagagaaa     3540

gatctacagg aagtgaaggc agcagctcga gatggcaagc ttaaaccctt acctggggag     3600

acaatggaga agtgtaccca ggacctgggc aacagcacca aagccgtgag ctcagccatc     3660

gcccagctac tgggagaggt tgcccagggc aatgagaatt atgcaggtat tgcagctcgg     3720

gatgtggcag gtgggctgcg gtcactggcc caggccgcta ggggagtcgc tgcactgacg     3780

tcagatcctg cagtgcaggc cattgtactt gatacggcca gtgatgtgct ggacaaggcc     3840

agcagcctca ttgaggaggc gaaaaaggca gctggccatc caggggaccc tgagagccag     3900

cagcggcttg cccaggtggc taaagcagtg acccaggctc tgaaccgctg tgtcagctgc     3960

ctacctggcc agcgcgatgt ggataatgcc ctgagggcag ttggagatgc cagcaagcga     4020

ctcctgagtg actcgcttcc tcctagcact gggacatttc aagaagctca gagccggttg     4080

aatgaagctg ctgctgggct gaatcaggca gccacagaac tggtgcaggc ctctcgggga     4140

acccctcagg acctggctcg agcctcaggc cgatttggac aggacttcag caccttcctg     4200

gaagctggtg tggagatggc aggccaggct ccgagccagg aggaccgagc ccaagttgtg     4260

tccaacttga agggcatctc catgtcttca agcaaacttc ttctggctgc caaggccctg     4320

tccacggacc ctgctgcccc taacctcaag agtcagctgg ctgcagctgc cagggcagta     4380

actgacagca tcaatcagct catcactatg tgcacccagc aggcacccgg ccagaaggag     4440

tgtgataacg ccctgcggga attggagacg gtccgggaac tcctggagaa cccagtccag     4500

cccatcaatg acatgtccta ctttggttgc ctggacagtg taatggagaa ctcaaaggtg     4560

ctgggcgagg ccatgactgg catctcccaa aatgccaaga acggaaacct gccagagttt     4620

ggagatgcca tttccacagc ctcaaaggca ctttgtggct tcaccgaggc agctgcacag     4680

gctgcatatc tggttggtgt ctctgacccc aatagccaag ctggacagca agggctagtg     4740

gagcccacac agtttgcccg tgcaaaccag gcaattcaga tggcctgcca gagtttggga     4800

gagcctggct gtacccaggc ccaggtgctc tctgcagcca ccattgtggc taaacacacc     4860

tctgcactgt gtaacagctg tcgcctggct tctgcccgta ccaccaatcc tactgccaag     4920

cgccagtttg tacagtcagc caaggaggtg gccaacagca cagctaatct tgtcaagacc     4980

atcaaggcgc tagatggggc cttcacagag gagaaccgtg cccagtgccg agcagcaaca     5040

gcccctctgc tggaggctgt ggacaatctg agtgcctttg cgtccaaccc tgagttctcc     5100

agcattcctg cccagatcag ccctgagggt cgggctgcca tggagcccat tgtgatctct     5160

gccaagacaa tgttagagag tgccggggga ctcatccaga cagcccgggc cctcgcagtc     5220

aatccccggg accccccgag ctggtcggtg ctggccggcc actcccgtac tgtctcagac     5280

tccatcaaga agctaattac aagcatgagg gacaaggctc cagggcagct ggagtgtgaa     5340

acggccattg cagctctgaa cagttgtcta cgggacctag accaggcttc cctcgctgca     5400

gtcagccagc agcttgctcc ccgtgaggga atctctcaag aggccttgca cactcagatg     5460

ctcactgcag tccaagagat ctcccatctc attgagccgc tggccaatgc tgcccgggct     5520

gaagcctccc agctgggaca caaggtgtcc cagatggcgc agtactttga gccgctcacc     5580

ctggctgcag tgggtgctgc ctccaagacc ctgagccacc cgcagcagat ggcactcctg     5640

gaccagacta aaacattggc agagtctgcc ctgcagttgc tatacactgc caaggaggct     5700

ggtggtaacc caaagcaagc agctcacacc caggaagccc tggaggaggc tgtgcagatg     5760

atgaccgagg ccgtagagga cctgacaaca accctcaacg aggcagccag tgctgctggg     5820

gtcgtgggtg gcatggtgga ctccatcacc caggccatca accagctaga tgaaggacca     5880

atgggtgaac cagaaggttc cttcgtggat taccaaacaa ctatggtgcg gacagccaag     5940

gccattgcag tgaccgttca ggagatggtt accaagtcaa acaccagccc agaggagctg     6000

ggccctcttg ctaaccagct gaccagtgac tatggccgtc tggcctcgga ggccaagcct     6060

gcagcggtgg ctgctgaaaa tgaagagata ggttcccata tcaaacaccg ggtacaggag     6120

ctgggccatg gctgtgccgc tctggtcacc aaggcaggcg ccctgcagtg cagccccagt     6180

gatgcctaca ccaagaagga gctcatagag tgtgcccgga gagtctctga gaaggtctcc     6240

cacgtcctgg ctgcgctcca ggctgggaat cgtggcaccc aggcctgcat cacagcagcc     6300

agcgctgtgt ctggtatcat tgctgacctc gacaccacca tcatgttcgc cactgctggc     6360

acgctcaatc gtgagggtac tgaaactttc gctgaccacc gggagggcat cctgaagact     6420

gcgaaggtgc tggtggagga caccaaggtc ctggtgcaaa acgcagctgg gagccaggag     6480

aagttggcgc aggctgccca gtcctccgtg gcgaccatca cccgcctcgc tgatgtggtc     6540

aagctgggtg cagccagcct gggagctgag gaccctgaga cccaggtggt actaatcaac     6600

gcagtgaaag atgtagccaa agccctggga gacctcatca gtgcaacgaa ggctgcagct     6660

ggcaaagttg gagatgaccc tgctgtgtgg cagctaaaga actctgccaa ggtgatggtg     6720

accaatgtga catcattgct taagacagta aaagccgtgg aagatgaggc caccaaaggc     6780

actcgggccc tggaggcaac cacagaacac atacggcagg agctggcggt tttctgttcc     6840

ccagagccac ctgccaagac ctctacccca gaagacttca tccgaatgac caagggtatc     6900

accatggcaa ccgccaaggc cgttgctgct ggcaattcct gtcgccagga agatgtcatt     6960

gccacagcca atctgagccg ccgtgctatt gcagatatgc ttcgggcttg caaggaagca     7020

gcttaccacc cagaagtggc ccctgatgtg cggcttcgag ccctgcacta tggccgggag     7080

tgtgccaatg gctacctgga actgctggac catgtactgc tgaccctgca gaagccaagc     7140

ccagaactga agcagcagtt gacaggacat tcaaagcgtg tggctggttc cgtcactgag     7200

ctcatccagg ctgctgaagc catgaaggga acagaatggg tagacccaga ggaccccaca     7260

gtcattgctg agaatgagct cctgggagct gcagccgcca ttgaggctgc agccaaaaag     7320

ctagagcagc tgaagccccg ggccaaaccc aaggaggcag atgagtcctt gaactttgag     7380

gagcagatac tagaagctgc caagtccatt gcagcagcca ccagtgcact ggtaaaggct     7440

gcgtcggctg cccagagaga actagtggcc caagggaagg tgggtgccat tccagccaat     7500

gcactggacg atgggcagtg gtcccagggc ctcatttctg ctgcccggat ggtggctgcg     7560

gccaccaaca atctgtgtga ggcagccaat gcagctgtac aaggccatgc cagccaggag     7620

aagctcatct catcagccaa gcaggtagct gcctccacag cccagctcct tgtggcctgc     7680

aaggtcaagg ctgaccagga ctcggaggca atgaaacgac ttcaggctgc tggcaacgca     7740

gtgaagcgag cctcagataa tctggtgaaa gcagcacaga aggctgcagc ctttgaagag     7800

caggagaatg agacagtggt ggtgaaagag aagatggttg gcggcattgc ccagatcatc     7860

gcagcacagg aagaaatgct tcggaaggaa cgagagctgg aagaggcgcg gaagaaactg     7920

gcccagatcc ggcagcagca gtacaagttt ctgccttcag agcttcgaga tgagcactaa     7980

agaagcctct tctatttaat gcagacccgg cccagagact gtgcgtgcca ctaccaaagc     8040

cttctgggct gtcggggccc aacctgccca accccagcac tccccaaagt gcctgccaaa     8100

ccccagggcc tggccccgcc cagtcccgca gtacatcccc tgtcccctcc ccaaccccaa     8160

gtgccttcat gccctagggc cccccaagtg cctgcccctc cccagagtat taacgctcca     8220

agagtattat taacgctgct gtacctcgat ctgaatctgc cggggcccca gcccactcca     8280

ccctgccagc agcttccggc cagtccccac agcctcatca gctctcttca ccgttttttg     8340

atactatctt cccccacccc cagctaccca taggggctgc agagttataa gccccaaaca     8400

ggtcatgctc caataaaaat gattctacct acaa                                 8434


<210>  78
<211>  2902
<212>  DNA
<213>  Homo sapiens

<400>  78
ggcatttgcg gccggcgcca gggtggagag ttgtgcgccg gtccctgggc ctgagctccg       60

gctccggctg gggcgcctgc gatgtctcaa gatggcggag ctgggcgaat taaagcacat      120

ggtgatgagt ttccgggtgt ctgagctcca ggtgcttctt ggctttgctg gccggaacaa      180

gagtggacgg aagcacgagc tcctggccaa ggctctgcac ctcctgaagt ccagctgtgc      240

ccctagtgtc cagatgaaga tcaaagagct ttaccgacga cgctttcccc ggaagaccct      300

ggggccctct gatctctccc ttctctcttt gccccctggc acctctcctg taggctcccc      360

tggtcctcta gctcccattc ccccaacgct gttggcccct ggcaccctgc tgggccccaa      420

gcgtgaggtg gacatgcacc cccctctgcc ccagcctgtg caccctgatg tcaccatgaa      480

accattgccc ttctatgaag tctatgggga gctcatccgg cccaccaccc ttgcatccac      540

ttctagccag cggtttgagg aagcgcactt tacctttgcc ctcacacccc agcaagtgca      600

gcagattctt acatccagag aggttctgcc aggagccaaa tgtgattata ccatacaggt      660

gcagctaagg ttctgtctct gtgagaccag ctgcccccag gaagattatt ttccccccaa      720

cctctttgtc aaggtcaatg ggaaactgtg ccccctgccg ggttaccttc ccccaaccaa      780

gaatggggcc gagcccaaga ggcccagccg ccccatcaac atcacacccc tggctcgact      840

ctcagccact gttcccaaca ccattgtggt caattggtca tctgagttcg gacggaatta      900

ctccttgtct gtgtacctgg tgaggcagtt gactgcagga acccttctac aaaaactcag      960

agcaaagggt atccggaacc cagaccactc gcgggcactg atcaaggaga aattgactgc     1020

tgaccctgac agtgaggtgg ccactacaag tctccgggtg tcactcatgt gcccgctagg     1080

gaagatgcgc ctgactgtcc cttgtcgtgc cctcacctgc gcccacctgc agagcttcga     1140

tgctgccctt tatctacaga tgaatgagaa gaagcctaca tggacatgtc ctgtgtgtga     1200

caagaaggct ccctatgaat ctcttatcat tgatggttta tttatggaga ttcttagttc     1260

ctgttcagat tgtgatgaga tccaattcat ggaagatgga tcctggtgcc caatgaaacc     1320

caagaaggag gcatctgagg tttgcccccc gccagggtat gggctggatg gcctccagta     1380

cagcccagtc caggggggag atccatcaga gaataagaag aaggtcgaag ttattgactt     1440

gacaatagaa agctcatcag atgaggagga tctgccccct accaagaagc actgttctgt     1500

cacctcagct gccatcccgg ccctacctgg aagcaaagga gtcctgacat ctggccacca     1560

gccatcctcg gtgctaagga gccctgctat gggcacgttg ggtggggatt tcctgtccag     1620

tctcccacta catgagtacc cacctgcctt cccactggga gccgacatcc aaggtttaga     1680

tttattttca tttcttcaga cagagagtca gcactatggc ccctctgtca tcacctcact     1740

agatgaacag gatgcccttg gccacttctt ccagtaccga gggacccctt ctcactttct     1800

gggcccactg gcccccacgc tggggagctc ccactgcagc gccactccgg cgccccctcc     1860

tggccgtgtc agcagcattg tggcccctgg gggggccttg agggaggggc atggaggacc     1920

cctgccctca ggtccctctt tgactggctg tcggtcagac atcatttccc tggactgagt     1980

tccctggatt atggaaactt cgctgtcccc caacactgag caagtatgct gtggagtccc     2040

aaccccagct actctgatcc ctctgggggc tctggccaag ggccagacag accttcacag     2100

atgcctactt ttggcctcat ctctgcctga caaggccagc acccaaaggg ttaatattta     2160

acctcttttt aaggacactg gggtctgttt ctggaaatgt tctttagatg gtggcacatt     2220

cctttgggta tgttaaccta ggcagtggga ggcaaatggg atggtatgtg agctaggaga     2280

agggctgaac cctcagcctt gactatgtct agagcctctt ggggaagggg cacctctctt     2340

gaaccccaaa tgctctctct tcttattacc caaacccatg gctctatttc ttcttcacat     2400

ccattgtctc ttcatgtcta ttccattccc ttcggccaaa cagacaggtg gaaaaactga     2460

gacaggcagt ttcagagatg gacagagaac tttattttgg attgtggatg tggacttttt     2520

tgtacataaa taagaaaaac caaaatactc caaagatgac ttcccctgcc tcctactcca     2580

gtatgacaga ggaggatgta aggccttagc catgatctgc aggggtctgg gagtcaggcc     2640

cggcctattg cttgggtctc tctctattta tatatctaag ttcacagtgt ttcttattcc     2700

cccctaagct tctagaggct catggccctg tagttaggcc tggctcattc tgcacctttc     2760

cagggaggtg gaaggaccct gtgccctcct tcccaatctt ctttttcagg ctcgccaagg     2820

cctaggacct atgttgtaat tttacttttt atttctaaag ttgtagtgaa gctctcaccc     2880

ataataaagg ttgtgaatgt tc                                              2902


<210>  79
<211>  1384
<212>  DNA
<213>  Homo sapiens

<400>  79
gtaagaaacg gttgaactgg atgcaatttt tatcacagct tgtgtaagac tgcctctgtc       60

cctcctctca catgccattg gttaaccagc agacagtgtg ctcaggggcg ttgccagctc      120

attgctctta tagcctgtga gggaggaaga aagaaacatt tgccagccag gctagtgaca      180

gaaatggatt cgaaatatca gtgtgtgaag ctgaatgatg gtcacttcat gcctgtcctg      240

ggatttggca cctatgcgcc tgcagaggtt cctaaaagta aagctttaga ggccaccaaa      300

ttggcaattg aagctggctt ccgccatatt gattctgctc atttatacaa taatgaggag      360

caggttggac tggccatccg aagcaagatt gcagatggca gtgtgaagag agaagacata      420

ttctacactt caaagctttg gtgcaattcc catcgaccag agttggtccg accagccttg      480

gaaaggtcac tgaaaaatct tcaattggat tatgttgacc tctaccttat tcattttcca      540

gtgtctgtaa agccaggtga ggaagtgatc ccaaaagatg aaaatggaaa aatactattt      600

gacacagtgg atctctgtgc cacatgggag gccgtggaga agtgtaaaga tgcaggattg      660

gccaagtcca tcggggtgtc caacttcaac cgcaggcagc tggagatgat cctcaacaag      720

ccagggctca agtacaagcc tgtctgcaac caggtggaat gtcatcctta cttcaaccag      780

agaaaactgc tggatttctg caagtcaaaa gacattgttc tggttgccta tagtgctctg      840

ggatcccacc gagaagaacc atgggtggac ccgaactccc cggtgctctt ggaggaccca      900

gtcctttgtg ccttggcaaa aaagcacaag cgaaccccag ccctgattgc cctgcgctac      960

cagctacagc gtggggttgt ggtcctggcc aagagctaca atgagcagcg catcagacag     1020

aacgtgcagg tgtttgaatt ccagttgact tcagaggaga tgaaagccat agatggccta     1080

aacagaaatg tgcgatattt gacccttgat atttttgctg gcccccctaa ttatccattt     1140

tctgatgaat attaacatgg agggcattgc atgaggtctg ccagaaggcc ctgcgtgtgg     1200

atggtgacac agaggatggc tctatgctgg tgactggaca catcgcctct ggttaaatct     1260

ctcctgcttg gtgatttcag caagctacag caaagcccat tggccagaaa ggaaagacaa     1320

taattttgtt ttttcatttt gaaaaaatta aatgctctct cctaaagatt cttcacctaa     1380

aaaa                                                                  1384


<210>  80
<211>  1870
<212>  DNA
<213>  Homo sapiens

<400>  80
ctccgagacg ggtggggccg gagctccaag ctggtttgaa caagccctgg gcatgtttgg       60

cgggaagttg gcttagctcg gctacctgtg gccccgcagt tttgtagtcc ccgccttgtt      120

tctccccaga ggcctctcaa tcctccctcc atgatcttcg catagagcac agtacccctt      180

cacacggagg acgcgatggc tcccaagaaa cgcccagaaa cccagaagac ctccgagatt      240

gtattacgcc ccaggaacaa gaggagcagg agtcccctgg agctggagcc cgaggccaag      300

aagctctgtg cgaagggctc cggtcctagc agaagatgtg actcagactg cctctgggtg      360

gggctggctg gcccacagat cctgccacca tgccgcagca tcgtcaggac cctccaccag      420

cataagctgg gcagagcttc ctggccatct gtccagcagg ggctccagca gtcctttttg      480

cacactctgg attcttaccg gatattacaa aaggctgccc cctttgacag gagggctaca      540

tccttggcgt ggcacccaac tcaccccagc accgtggctg tgggttccaa agggggagat      600

atcatgctct ggaattttgg catcaaggac aaacccacct tcatcaaagg gattggagct      660

ggagggagca tcactgggct gaagtttaac cctctcaata ccaaccagtt ttacgcctcc      720

tcaatggagg gaacaactag gctgcaagac tttaaaggca acattctacg agtttttgcc      780

agctcagaca ccatcaacat ctggttttgt agcctggatg tgtctgctag tagccgaatg      840

gtggtcacag gagacaacgt ggggaacgtg atcctgctga acatggacgg caaagagctt      900

tggaatctca gaatgcacaa aaagaaagtg acgcatgtgg ccctgaaccc atgctgtgat      960

tggttcctgg ccacagcctc cgtagatcaa acagtgaaaa tttgggacct gcgccaggtt     1020

agagggaaag ccagcttcct ctactcgctg ccgcacaggc atcctgtcaa cgcagcttgt     1080

ttcagtcccg atggagcccg gctcctgacc acggaccaga agagcgagat ccgagtttac     1140

tctgcttccc agtgggactg ccccctgggc ctgatcccgc accctcaccg tcacttccag     1200

cacctcacac ccatcaaggc agcctggcat cctcgctaca acctcattgt tgtgggccga     1260

tacccagatc ctaatttcaa aagttgtacc ccttatgaat tgaggacgat cgacgtgttc     1320

gatggaaact cagggaagat gatgtgtcag ctctatgacc cagaatcttc tggcatcagt     1380

tcgcttaatg aattcaatcc catgggggac acgctggcct ctgcaatggg ttaccacatt     1440

ctcatctgga gccaggagga agccaggaca cggaagtgag agacactaaa gaaggtgtgg     1500

gccagacaag gccttggagc ccacacatgg gatcaagtcc tgcaagcaga ggtggcgatt     1560

tgttaaaggg ccaaaagtat ccaaggttag ggttggagca ggggtgctgg gacctggggc     1620

actgtgggac tgggacactt ttatgttaat gctctggact tgcctccaga gactgctcca     1680

gagttggtga cacagctgtc ccaagggccc ctctgtatct agcctggaac caaggttatc     1740

ttggaactaa atgacttttc tcctctcagt gggtggtagc agagggatca agcagttatt     1800

tgatttgtgc tcacttttga tatggccaat aaaaccatac cgactgagaa aaaaaaaaaa     1860

aaaaaaaaaa                                                            1870


<210>  81
<211>  9655
<212>  DNA
<213>  Homo sapiens

<400>  81
ggcagccagg agaggcagtg gagcttttct ccgttgactg tcagaagaaa gtgactgttg       60

ttgaaaatgt ttgctgcaac taaaggagag ctgctaagat ctactttcta gttaaacaag      120

cttttatatt tctccccggc tcctctcagt tcccttggga aatcaactaa ttgtgtgtgt      180

aagctaagtg tgtggaggag agaagatgca aaaaggaaga gaaaggtggg gaaagaagga      240

aattgggaac aattagacaa aaagactata gtttgaggcc atcaggagta ttctagtctg      300

actgaagcca ggcagaaggc acagtatctc ttgtcctcct gggttttaag cagctgcaac      360

aggaggagga actgcggctt gtgtttacaa ggccgaaatc tgaagaaaaa gcttccattc      420

ttttcccatc ttgatatgga gggttctcca gaggaaaata aggaaatgag atattacatg      480

cttcaaaggt ccagcatgtc tggcttgcac ctagtaaagc agggccgaga cagaaagaaa      540

atagattctc aacgagattt cactgtggct tctccagcag aatttgttac tcgctttggg      600

ggaaataaag tgattgagaa ggttcttatt gctaacaatg gcattgcagc agtgaaatgc      660

atgcggtcta tccgtaggtg gtcttatgaa atgtttcgaa atgaacgtgc aattagattc      720

gttgtcatgg tcacacctga agaccttaaa gccaatgcag aatacattaa gatggcagat      780

cactatgtgc cagtgcctgg aggaccaaac aacaacaact atgcaaatgt ggaattaatt      840

cttgatattg ctaaaaggat cccagtacaa gcagtgtggg ctggctgggg tcatgcttct      900

gagaatccca aactaccgga acttctcttg aaaaatggca ttgccttcat gggtcctcca      960

agccaggcca tgtgggcttt aggggataag attgcatctt ccatagtggc tcaaactgca     1020

ggtatcccaa ctcttccctg gagcggcagt ggtcttcgtg tggactggca ggaaaatgat     1080

ttttcaaaac gtatcttaaa tgttccccag gagctatatg aaaaaggtta tgtgaaagat     1140

gtggatgatg ggctacaggc agctgaggaa gttggatatc cagtaatgat caaggcctca     1200

gagggaggag gagggaaggg aattagaaaa gtcaacaatg cagatgactt ccctaatctc     1260

ttcagacagg ttcaagctga agttcctgga tctcccatat ttgtgatgag actagccaaa     1320

caatctcgtc atctggaggt gcagatctta gcggaccaat atggcaatgc tatctctttg     1380

tttggtcgtg attgctctgt acaacgcagg catcagaaga ttattgaaga agcacctgct     1440

actattgcta ctccagcagt atttgaacac atggaacagt gtgcggtgaa acttgccaaa     1500

atggtgggtt atgtgagtgc tgggactgtg gaatacctgt acagccagga tggcagcttc     1560

tactttctgg aattgaatcc tcggctgcag gtagagcacc cttgtacaga gatggtggct     1620

gatgtcaatc tccctgcagc acagctccag attgccatgg ggattcctct atatagaatc     1680

aaggatatcc gtatgatgta tggggtatct ccctggggtg attctcccat tgattttgaa     1740

gattctgcac acgttccttg tccaaggggc catgttattg ctgctcggat cactagtgaa     1800

aatccagatg agggttttaa gcccagctca ggaacagttc aggagctaaa tttccgcagc     1860

aataagaatg tttggggata tttcagtgtt gctgctgcag ggggacttca tgaatttgct     1920

gattctcagt ttggtcactg cttttcttgg ggagaaaaca gagaagaggc aatttcaaac     1980

atggtggtgg ctttgaagga gctgtctatt cggggtgact ttcgaactac agttgaatac     2040

ctgatcaaat tgttagagac tgaaagcttt cagatgaaca gaattgatac tggctggctg     2100

gacagactga tagcagaaaa agtacaggct gagcgacctg acaccatgtt gggggttgtg     2160

tgtggtgccc tccacgtggc agatgtgagc ctgcggaata gcgtctctaa cttccttcac     2220

tccttagaaa ggggtcaagt ccttcctgct catacacttc tgaatacagt agatgttgaa     2280

cttatctatg agggagtcaa gtatgtactt aaggtgactc gacagtcccc caactcctat     2340

gtggtgatca tgaatggctc atgtgtagaa gtagatgtac atcggctgag tgacggtgga     2400

ctgctcttgt cctatgatgg cagcagttat actacgtata tgaaagagga agtggataga     2460

tatcgcatca caattggcaa taaaacctgt gtgtttgaga aggaaaatga cccatcggtg     2520

atgcgctcac cttctgctgg gaagttaatc cagtacattg tagaagatgg aggtcatgtg     2580

tttgccggcc agtgctatgc tgagattgag gtaatgaaga tggtaatgac cttaacagct     2640

gtggagtctg gctgtatcca ttacgtcaag cgacctggag cagctcttga ccctggctgt     2700

gtactagcca aaatgcaact ggacaacccc agcaaggttc agcaggctga acttcacaca     2760

ggtagtctgc cacggatcca gagcacggca ctcagaggcg agaaactcca tcgagtgttc     2820

cattatgtcc tggataatct ggtcaatgta atgaatggat actgccttcc agatcctttc     2880

tttagcagca aggtaaaaga ctgggtagag cgattgatga aaaccctcag agatccctcc     2940

ctgcctctcc tagaattgca agatattatg accagtgtgt ctggccgcat tccccccaat     3000

gtggagaagt ctatcaagaa ggaaatggct cagtatgcta gcaacatcac atcagtcctc     3060

tgtcagtttc ccagccagca gattgcaaac atcctagata gccatgcagc tacattgaac     3120

cggaaatctg aacgggaagt cttctttatg aatactcaga gcattgttca gctggtacag     3180

aggtaccgaa gtggcatccg aggccacatg aaggctgtgg tgatggatct gctccggcag     3240

tacctgcgag tagagacaca attccagaat ggtcactatg acaaatgtgt attcgccctc     3300

cgagaagaga ataaaagtga catgaacact gtactgaact acatcttctc tcacgctcaa     3360

gtcaccaaga agaatcttct ggtcacaatg cttattgatc agttgtgtgg ccgggaccct     3420

actctcactg atgagctgct gaatattctc acagagctaa ctcaactcag taagaccacc     3480

aatgccaaag tagcacttcg agcacgccag gttcttattg cctcccattt gccatcatat     3540

gagcttcgcc ataaccaagt agagtctatc ttcctatcag ctattgacat gtatggacat     3600

caattttgca ttgagaacct gcagaaactc atcctatcag aaacatctat ttttgatgtc     3660

ctaccaaact tcttctatca cagcaaccaa gtagtgagga tggcagctct ggaggtgtat     3720

gttcgaaggg cttatattgc ctatgaactt aacagcgtac aacaccgcca gcttaaggac     3780

aacacctgtg tggtggaatt ccagttcatg ctgcccacat ctcatccaaa cagagggaac     3840

atccctacgc taaacagaat gtccttctcc tccaacctca accactatgg catgacccat     3900

gtagctagtg tcagcgatgt actgttggac aactcattca ctccaccttg tcagcggatg     3960

ggcggaatgg tctcttttcg gacttttgaa gattttgtca ggatctttga tgaagtgatg     4020

ggctgcttct ctgactcccc accccagagt cccacattcc ctgaggcagg tcacacgtct     4080

ctttatgatg aggataaggt tcccagggat gaaccaattc acattctcaa tgtggctatc     4140

aagactgact gtgatattga ggatgacagg ctggcagcta tgttcagaga atttacccag     4200

caaaataaag ctaccctggt tgaccatggg atccggcgcc ttactttcct ggttgcacaa     4260

aaggatttca gaaagcaggt caactatgag gtggatcgga gatttcatag agaattccct     4320

aaatttttta cattccgagc aagggataag tttgaggagg atcgtatcta tcgtcatctg     4380

gagcctgctc tggctttcca gttagagctg aaccggatga gaaattttga cctcactgcc     4440

attccatgtg ctaatcacaa gatgcacctg tatctcgggg cagccaaggt ggaagtgggc     4500

acagaagtga cagactacag gttctttgtt cgtgcaatca tcaggcattc tgatctggtc     4560

accaaggaag cttcttttga atatctgcaa aatgaagggg agcggctact cctggaagcc     4620

atggatgagt tggaagttgc ttttaacaat acaaatgtcc gcactgactg taaccacatc     4680

ttcctcaact ttgtgcccac ggttatcatg gacccatcaa agattgagga atccgtgcgg     4740

agcatggtaa tgcggtatgg aagtcgcctg tggaaattgc gcgtcctcca ggcagaactg     4800

aaaatcaaca ttcgcctgac gccaactgga aaagcaattc ccatccgcct cttcctgaca     4860

aacgagtctg gctattactt ggatatcagc ctatacaagg aagtgactga ctccaggaca     4920

gcacagatca tgtttcaggc atatggagac aaacagggac cactgcatgg aatgttaatc     4980

aatactccat atgtgaccaa agacctgctg caatcaaaga ggttccaggc acaatcctta     5040

gggacaacat acatatatga tatcccagag atgtttcggc agtccctgat caaactctgg     5100

gagtctatgt ccactcaagc atttcttcca tctccccctc tgccttctga catgctgact     5160

tacactgaac tggtactgga tgatcaaggt cagctggtcc acatgaacag gcttccagga     5220

ggaaatgaga ttggcatggt agcttggaaa atgaccttta aaagtcctga atatccagaa     5280

ggccgagata tcattgttat tggcaatgac atcacatacc gaattgggtc ctttgggcct     5340

caagaggatt tgttatttct cagagcttcc gaacttgcta gggcagaagg tattccacgc     5400

atctatgtat cagccaacag tggagcaaga atcggactgg cagaagaaat tcgccatatg     5460

tttcatgtgg cctgggtaga tcctgaggat ccttacaagg gatacaggta tttatatctg     5520

actcctcaag attataagag agtcagtgct ctcaactctg tccattgtga acacgtggaa     5580

gatgaaggag aatccaggta caagataaca gatattattg ggaaagaaga gggaattgga     5640

cccgagaacc ttcgaggttc tggaatgatt gctggagaat cctcattggc ctataatgag     5700

atcattacca tcagcctggt gacgtgccgg gccattggga ttggggctta ccttgtccgg     5760

ctgggacaga gaaccatcca ggttgagaat tctcacttaa ttctaacagg agctggagcc     5820

ctcaacaaag tcctcgggcg ggaagtgtac acctccaata accagctggg gggcatccag     5880

attatgcaca acaatggggt gacccactgc actgtgtgtg atgactttga aggggttttc     5940

actgtcctgc actggctgtc ttacatgccc aagagcgtgc acagttcagt tcctcttctg     6000

aactcaaagg atcctataga cagaatcatc gagtttgttc ccacaaagac cccatacgat     6060

cctcgatgga tgctagcagg ccgtcctcac ccaacccaaa aaggtcagtg gttgagtggc     6120

ttttttgact atggatcttt ctcagagatt atgcagccct gggcacagac tgtggtggtt     6180

ggtagagcca ggctaggagg aatacctgtg ggagttgttg ctgtagaaac ccgaacagta     6240

gaactaagta tcccagctga tccagcaaac ctggattctg aagccaagat aatccagcag     6300

gctggccagg tttggttccc agattctgcg tttaagacgt atcaggccat caaggacttc     6360

aaccgggaag ggctgcctct gatggtcttt gccaactgga gaggcttctc tggtggaatg     6420

aaagatatgt acgaccaagt gctgaagttt ggtgcttaca ttgtggatgg cttgagggag     6480

tgctgccagc ctgtgctggt ttacattcct ccccaggctg agctgcgggg tggctcctgg     6540

gtggtgattg actcctccat caacccccgg cacatggaga tgtatgctga ccgagaaagc     6600

aggggatctg ttctggagcc agaagggaca gtagaaatca aattccgcag aaaggatctg     6660

gtgaaaacca tgcgtcgggt ggacccagtc tacatccact tggctgagcg attggggacc     6720

ccagagctaa gcacagctga gcggaaggag ttggagaaca agttgaagga gcgggaggaa     6780

ttcctaattc ccatttacca tcaggtagcc gtgcagtttg ctgacttgca cgacacacca     6840

ggccggatgc aggagaaggg tgttattagc gatatcctgg attggaaaac atcccgtacc     6900

ttcttctact ggcggctgag gcgtcttctg ctggaggacc tggtcaagaa gaaaatccac     6960

aatgccaacc ctgagctgac tgatggccag attcaagcca tgttaaggcg ctggtttgtg     7020

gaagtggaag gaacagtgaa ggcttatgtt tgggacaata ataaggatct ggcggagtgg     7080

ctagagaaac agctgacaga ggaggatggt gttcactcgg taatagagga aaacatcaaa     7140

tgcatcagca gagactacgt cctcaagcaa atccgcagct tggtccaggc caatccagag     7200

gttgccatgg attccatcat ccatatgacg cagcacatat cacccactca gcgagcagaa     7260

gtcatacgga tcctctccac aatggattcc ccttccacgt aggaagagct tcctgcctgt     7320

ccctgccctg tctctggaga aaagggctag agctgccttt tacaactgta accactgtaa     7380

tgagaaggca caggagaccc agcactggag tcaaatggca ttttacttcc tctcgtttca     7440

ggttatgcat gacatcctgg gatgtaagat cacagaatcc ccctccagcc caccagtcac     7500

acctacccca ttcagtattt attaccctgg ccaggcctag tcctccactc cctgcacagg     7560

actgagaagg caatgaaagg tacaaacatg taccatgagg tcttactaac caaagtaggg     7620

ctgcccctcc tgtcctgaca gccccttggc ctcccagcat ggggaagcgt gaggagttgc     7680

ccagcagtga gcagcccccc tcactcctgg ccccatgagc cgcagccaca ggcagcagag     7740

gagggctaag gagaggagga agcctcaagt ccattgttta ttaccccgac tcttagccca     7800

gcacacagta ggcactggag aggaatgatt cccagtttaa ccacactacg gtacctttta     7860

tgaagaaaaa ttagagcata aaatctacta caagctccat aggaactcaa agatgagggc     7920

aaaactgtga gccaagaagc agagaaagaa aatagaacca gttattcttg atttagggga     7980

cctcaacctt gggttcagtc tctgaggaca aagggaaagg tagttgttgg cctgcctctc     8040

gcctgcacgt cactgctgga ctagctgtcg catgtggctg ggagctgcaa ggccagtgct     8100

tgaggggccc cagcagttcc acaggtggtg aagcctgagt tggcagagga ggagccagaa     8160

gagaactgcc ctttctgcac tggtggaaac tagttattta tgccatgtgg agagccagtg     8220

agatagatag atagtctgtt tgttttgagg acttggaaag ttgttcctat gaagcctgga     8280

gcttggatgg ttttgagagg ttaatggtgc ctccacactc actcttccct agttccagga     8340

ttactgtcct agcagctaac ggttctactc tcttccccag agtgtagaca ggcagcaggt     8400

ctccccacag ctctgaaagg accctggtga cagctacacc ctcagcacca ggagctggcc     8460

ttcctgatga gggaggcttc caggaaacac agaatccaca tgaccttaag attatttaca     8520

actcagtcat ggtgctgctg tcctccaggc ttactggccc ctcctgactg gcatcagggg     8580

cttcctcagg tggtggagag agtttacttt caacaactag tttattcaag aaaagaactt     8640

actgattcct ctgttcctaa agcaagagtg gcaggtgatc agggctggtg tagcatccgg     8700

ttcctttagt gcagctaact gcatttgtca ctgatgacca aggaggaaat cactaagaca     8760

tttgagaagc agtggtatga acgttcttgg acaagccaca gttctgagcc ttaaccctgt     8820

agtttgcaca caagaacgag ctccacctcc ccttcttcag gaggaatctg tgcggataga     8880

ttggctggac ttttcaatgg ttctgggttg caggtgggca ctgtatggct gggtatggag     8940

cggacagccc ccaggagtca gagcctcagc ccggctgccc tggtggaagg tacaggtgtt     9000

cagcaccttc agaaaagggc ataaagtggt gggggacaat tctcagtcca ggaaaatgca     9060

ttgaccattg ctggctattt gcttacctag taagaattgg attcattttt gaccagatta     9120

ttcttctatg cttttttgca ataaatcaaa tcccacatat ctacaagtgg tatgaagtcc     9180

tgcacccccc aggaggcctg tccaggcatg tcttcagagg cagggtgggt tacactcatt     9240

tacctcccct ctccccacca aattatgaca caaacgagta tgtttcctct ctagaaccct     9300

gtaatgcctc ctcccccatc cccagagctc cttactgtag gtcttaccct ggacaaggat     9360

tttttcaagt tggaggcaca gaacatgagc aatctgacat tcccacagcc cctcaaacat     9420

gcaaggctac taaggcagga ggagtataaa tgatggatat tgaccaagac ctgcttggac     9480

ggagaccgcc atattatctg ttctcttcgt tcacaaaaca gccttcactt gtctcagaat     9540

ttgatggaca catactgtga tgagcaggag cttcagatgc actctttaca cattttgttg     9600

aaataaacct ctacatttgt agaagaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa          9655


<210>  82
<211>  4126
<212>  DNA
<213>  Homo sapiens

<400>  82
ggggaagaga ggcacagaca cagataggag aagggcaccg gctggagcca cttgcaggac       60

tgagggtttt tgcaacaaaa ccctagcagc ctgaagaact ctaagccaga tggggtggct      120

ggacgagagc agctcttggc tcagcaaaga atgcacagta tgatcagctc agtggatgtg      180

aagtcagaag ttcctgtggg cctggagccc atctcacctt tagacctaag gacagacctc      240

aggatgatga tgcccgtggt ggaccctgtt gtccgtgaga agcaattgca gcaggaatta      300

cttcttatcc agcagcagca acaaatccag aagcagcttc tgatagcaga gtttcagaaa      360

cagcatgaga acttgacacg gcagcaccag gctcagcttc aggagcatat caaggaactt      420

ctagccataa aacagcaaca agaactccta gaaaaggagc agaaactgga gcagcagagg      480

caagaacagg aagtagagag gcatcgcaga gaacagcagc ttcctcctct cagaggcaaa      540

gatagaggac gagaaagggc agtggcaagt acagaagtaa agcagaagct tcaagagttc      600

ctactgagta aatcagcaac gaaagacact ccaactaatg gaaaaaatca ttccgtgagc      660

cgccatccca agctctggta cacggctgcc caccacacat cattggatca aagctctcca      720

ccccttagtg gaacatctcc atcctacaag tacacattac caggagcaca agatgcaaag      780

gatgatttcc cccttcgaaa aactgaatcc tcagtcagta gcagttctcc aggctctggt      840

cccagttcac caaacaatgg gccaactgga agtgttactg aaaatgagac ttcggttttg      900

ccccctaccc ctcatgccga gcaaatggtt tcacagcaac gcattctaat tcatgaagat      960

tccatgaacc tgctaagtct ttatacctct ccttctttgc ccaacattac cttggggctt     1020

cccgcagtgc catcccagct caatgcttcg aattcactca aagaaaagca gaagtgtgag     1080

acgcagacgc ttaggcaagg tgttcctctg cctgggcagt atggaggcag catcccggca     1140

tcttccagcc accctcatgt tactttagag ggaaagccac ccaacagcag ccaccaggct     1200

ctcctgcagc atttattatt gaaagaacaa atgcgacagc aaaagcttct tgtagctggt     1260

ggagttccct tacatcctca gtctcccttg gcaacaaaag agagaatttc acctggcatt     1320

agaggtaccc acaaattgcc ccgtcacaga cccctgaacc gaacccagtc tgcacctttg     1380

cctcagagca cgttggctca gctggtcatt caacagcaac accagcaatt cttggagaag     1440

cagaagcaat accagcagca gatccacatg aacaaactgc tttcgaaatc tattgaacaa     1500

ctgaagcaac caggcagtca ccttgaggaa gcagaggaag agcttcaggg ggaccaggcg     1560

atgcaggaag acagagcgcc ctctagtggc aacagcacta ggagcgacag cagtgcttgt     1620

gtggatgaca cactgggaca agttggggct gtgaaggtca aggaggaacc agtggacagt     1680

gatgaagatg ctcagatcca ggaaatggaa tctggggagc aggctgcttt tatgcaacag     1740

gtaataggca aagatttagc tccaggattt gtaattaaag tcattatctg aacatgaaat     1800

gcattgcagg tttggtaaat ggatatgatt tcctatcagt ttatatttct ctatgatttg     1860

agttcagtgt ttaaggattc tacctaatgc agatatatgt atatatctat atagaggtct     1920

ttctatatac tgatctctat atagatatca atgtttcatt gaaaatccac tggtaaggaa     1980

atacctgtta tactaaaatt atgatacata atatctgagc agttaatagg ctttaaattt     2040

atcccaaagc ctgctacacc aattacttct aaagaaaaca aattcactgt tattttgagt     2100

ttatgtgttg agatcagtga ctgctggata gtctcccagt ctgatcaatg aagcattcga     2160

ttagtttttg attttttgca acatctagaa tttaattttc acatcactgt acataatgta     2220

tcatactata gtcttgaaca ctgttaaagg tagtctgccc cttccttcct ctctcttttt     2280

ttagttaagt agaaatgttc tggtcaccat gccagtagtc ctaggttatt gtgtaggttg     2340

caattgaaca tattaggaat acaggtggtt ttaaatatat agatgcaaat tgcagcacta     2400

ctttaaatat tagattatgt ctcacatagc actgctcatt ttacttttat tttgtgtaat     2460

ttgatgacac tgtctatcaa aaaagagcaa atgaagcaga tgcaaatgtt agtgagaagt     2520

aatgtgcagc attatggtcc aatcagatac aatattgtgt ctacaattgc aaaaaacaca     2580

gtaacaggat gaatattatc tgatatcaag tcaaaatcag tttgaaaaga aggtgtatca     2640

tattttatat tgtcactaga atctcttaag tataattcca taatgacatg ggcatatacc     2700

gtaacattct ggcaaataac aattagaaaa gataggttta acaaaaaaat ttacttgtat     2760

ataatgcacc ttcaggagga ctatgtcctt tgatgctata aaatacaaac aactttgaag     2820

gcaacagaag acactgttta ttcaagtcag ttctttgtca ggttcctgct gttctcctac     2880

agaaaagtga ttctgtgagg gtgaacagga aatgccttgt ggaaacagga agtccaagtg     2940

attcatgtac tgaggaatgt aggaaaaaaa atctgaggat agtgctttac tctttctgtt     3000

tttaaagggc actctatgaa ttgatttatt gtctaagaaa ataacaccac aagtagggaa     3060

attgttacgg aagcttttca ctggaacatt tccttcatat tcccttttga tatgtttacc     3120

ttgttttata ggtttacttt tgttaagcta gttaaaggtt cgttgtatta agaccccttt     3180

aatatggata atccaaattg acctagaatc tttgtgaggt tttttctatt aaaatattta     3240

tatttctaaa tccgaggtat ttcaaggtgt agtatcctat ttcaaaggag atatagcagt     3300

tttgccaaat gtagacattg ttcaactgta tgttattggc acgtgttgtt tacattttgc     3360

tgtgacattt aaaaatattt ctttaaaaat gttactgcta aagatacatt atcctttttt     3420

aaaaagtctc cattcaaatt aaattaacat aactagaagt tagaaagttt aaaagttttc     3480

cacataatga aagtccttct gataatttga caaatagcta taataggaac actccctatc     3540

accaacatat tttggttagt atattccttc atattaaaat gactttttgt cagttgtttt     3600

gcattaaaaa tatggcatgc ctaagataaa attgtatatt ttttccatct cataaatatt     3660

cattttcttc aaagtctttt ttcaatctca taaaaaaggg atagtgcatc ttttaaaata     3720

cattttattt ggggaggaac atgtggctga gcagactttt gtataatatt acttcaaaga     3780

tatgtaatca caaacaaaaa aaactatttt ttataatgtc atttgagaga gtttcatcag     3840

tacagttggt ggacgttaat tgtttgaatt tgatagtctt tgaatttaat caagaaacta     3900

cctggaacca gtgaaaagga aagctggact taaataatct tagaattaat tgataaatgt     3960

ctcttttaaa atctactgta tttattataa tttacaccct tgaaggtgat ctcttgtttt     4020

gtgttgtaaa tatattgttt gtatgtttcc cttcttgcct tctgttataa gtctcttcct     4080

ttctcaaata aagttttttt taaaagaaaa aaaaaaaaaa aaaaaa                    4126


<210>  83
<211>  6210
<212>  DNA
<213>  Homo sapiens

<400>  83
gagttcgcgg ccggtggcgg cggtggcgac agcggcgacc tagggatcga tctggaggga       60

cttggggagc gtgcagagac ctctagctcg agcgcgaggg acctcccgcc gggatgcctg      120

gggagcagat ggaccctact ggaagtcagt tggattcaga tttctctcag caagatactc      180

cttgcctgat aattgaagat tctcagcctg aaagccaggt tctagaggat gattctggtt      240

ctcacttcag tatgctatct cgacaccttc ctaatctcca gacgcacaaa gaaaatcctg      300

tgttggatgt tgtgtccaat cctgaacaaa cagctggaga agaacgagga gacggtaata      360

gtgggttcaa tgaacatttg aaagaaaaca aggttgcaga ccctgtggat tcttctaact      420

tggacacatg tggttccatc agtcaggtca ttgagcagtt acctcagcca aacaggacaa      480

gcagtgttct gggaatgtca gtggaatctg ctcctgctgt ggaggaagag aagggagaag      540

agttggaaca gaaggagaaa gagaaggaag aagatacttc aggcaatact acacattccc      600

ttggtgctga agatactgcc tcatcacagt tgggttttgg ggttctggaa ctctcccaga      660

gccaggatgt tgaggaaaat actgtgccat atgaagtgga caaagagcag ctacaatcag      720

taaccaccaa ctctggttat accaggctgt ctgatgtgga tgctaatact gcaattaagc      780

atgaagaaca gtccaacgaa gatatcccca tagcagaaca gtccagcaag gacatccctg      840

tgacagcaca gcccagtaag gatgtacatg ttgtaaaaga gcaaaatcca ccacctgcaa      900

ggtcagagga catgcctttt agccccaaag catctgttgc tgctatggaa gcaaaagaac      960

agttgtctgc acaagaactt atggaaagtg gactgcagat tcagaagtca ccagagcctg     1020

aggttttgtc aactcaggaa gacttgtttg accagagcaa taaaacagta tcttctgatg     1080

gttgctctac tccttcaagg gaggaaggtg ggtgttcttt ggcttccact cctgccacca     1140

ctctgcatct cctgcagctc tctggtcaga ggtcccttgt tcaggacagt ctttccacga     1200

attcttcaga tcttgttgct ccttctcctg atgctttccg atctactcct tttatcgttc     1260

ctagcagtcc cacagagcaa gaagggagac aagataagcc aatggacacg tcagtgttat     1320

ctgaagaagg aggagagcct tttcagaaga aacttcaaag tggtgaacca gtggagttag     1380

aaaacccccc tctcctgcct gagtccactg tatcaccaca agcctcaaca ccaatatctc     1440

agagcacacc agtcttccct cctgggtcac ttcctatccc atcccagcct cagttttctc     1500

atgacatttt tattccttcc ccaagtctgg aagaacaatc aaatgatggg aagaaagatg     1560

gagatatgca tagttcatct ttgacagttg agtgttctaa aacttcagag attgaaccaa     1620

agaattcccc tgaggatctt gggctatctt tgacagggga ttcttgcaag ttgatgcttt     1680

ctacaagtga atatagtcag tccccaaaga tggagagctt gagttctcac agaattgatg     1740

aagatggaga aaacacacag attgaggata cggaacccat gtctccagtt ctcaattcta     1800

aatttgttcc tgctgaaaat gatagtatcc tgatgaatcc agcacaggat ggtgaagtac     1860

aactgagtca gaatgatgac aaaacaaagg gagatgatac agacaccagg gatgacatta     1920

gtattttagc cactggttgc aagggcagag aagaaacggt agcagaagat gtttgtattg     1980

atctcacttg tgattcgggg agtcaggcag ttccgtcacc agctactcga tctgaggcac     2040

tttctagtgt gttagatcag gaggaagcta tggaaattaa agaacaccat ccagaggagg     2100

ggtcttcagg gtctgaggtg gaagaaatcc ctgagacacc ttgtgaaagt caaggagagg     2160

aactcaaaga agaaaatatg gagagtgttc cgttgcacct ttctctgact gaaactcagt     2220

cccaagggtt gtgtcttcaa aaggaaatgc caaaaaaaga atgctcagaa gctatggaag     2280

ttgaaaccag tgtgattagt attgattccc ctcaaaagtt ggcaatactt gaccaagaat     2340

tggaacataa ggaacaggaa gcttgggaag aagctacttc agaggactcc agtgttgtca     2400

ttgtagatgt gaaagagcca tctcccagag ttgatgtttc ttgtgaacct ttggagggag     2460

tggagaagtg ctcagattcc cagtcatggg aggatattgc tccagaaata gaaccatgtg     2520

ctgagaatag attagacacc aaggaagaaa agagtgtaga atatgaagga gatctgaaat     2580

cagggactgc agaaacagaa cctgtagagc aagattcttc acagccttcc ttacctttag     2640

tgagagcaga tgatccttta agacttgacc aggagttgca gcagccccaa actcaggaga     2700

aaacaagtaa ttcattaaca gaagactcaa aaatggctaa tgcaaagcag ctaagctcag     2760

atgcagaggc ccagaagctg gggaagccct ctgcccatgc ctcacaaagc ttctgtgaaa     2820

gttctagtga aaccccattt catttcactt tgcctaaaga aggtgatatc atcccaccat     2880

tgactggtgc aaccccacct cttattgggc acctaaaatt ggagcccaag agacacagta     2940

ctcctattgg tattagcaac tatccagaaa gcaccatagc aaccagtgat gtcatgtctg     3000

aaagcatggt ggagacccat gatcccatac ttgggagtgg aaaaggggat tctggggctg     3060

ccccagacgt ggatgataaa ttatgtctaa gaatgaaact ggttagtcct gagactgagg     3120

cgagtgaaga gtctttgcag ttcaacctgg aaaagcctgc aactggtgaa agaaaaaatg     3180

gatctactgc tgttgctgag tctgttgcca gtccccagaa gaccatgtct gtgttgagct     3240

gtatctgtga agccaggcaa gagaatgagg ctcgaagtga ggatcccccc accacaccca     3300

tcagggggaa cttgctccac tttccaagtt ctcaaggaga agaggagaaa gaaaaattgg     3360

agggtgacca tacaatcagg cagagtcaac agcctatgaa gcccattagt cctgtcaagg     3420

accctgtttc tcctgcttcc cagaagatgg tcatacaagg gccatccagt cctcaaggag     3480

aggcaatggt gacagatgtg ctagaagacc agaaagaagg acggagtact aataaggaaa     3540

atcctagtaa ggccttgatt gaaaggccca gccaaaataa cataggaatc caaaccatgg     3600

agtgttcctt gagggtccca gaaactgttt cagcagcaac ccagactata aagaatgtgt     3660

gtgagcaggg gaccagtaca gtggaccaga actttggaaa gcaagatgcc acagttcaga     3720

ctgagagggg gagtggtgag aaaccagtca gtgctcctgg ggatgataca gagtcgctcc     3780

atagccaggg agaagaagag tttgatatgc ctcagcctcc acatggccat gtcttacatc     3840

gtcacatgag aacaatccgg gaagtacgca cacttgtcac tcgtgtcatt acagatgtgt     3900

attatgtgga tggaacagaa gtagaaagaa aagtaactga ggagactgaa gagccaattg     3960

tagagtgtca ggagtgtgaa actgaagttt ccccttcaca gactgggggc tcctcaggtg     4020

acctggggga tatcagctcc ttctcctcca aggcatccag cttacaccgc acatcaagtg     4080

ggacaagtct ctcagctatg cacagcagtg gaagctcagg gaaaggagcc ggaccactca     4140

gagggaaaac cagcgggaca gaacccgcag attttgcctt acccagctcc cgaggaggcc     4200

caggaaaact gagtcctaga aaaggggtca gtcagacagg gacgccagtg tgtgaggagg     4260

atggtgatgc aggccttggc atcagacagg gagggaaggc tccagtcacg cctcgtgggc     4320

gtgggcgaag gggccgccca ccttctcgga ccactggaac cagagaaaca gctgtgcctg     4380

gccccttggg catagaggac atttcaccta acttgtcacc agatgataaa tccttcagcc     4440

gtgtcgtgcc ccgagtgcca gactccacca gacgaacaga tgtgggtgct ggtgctttgc     4500

gtcgtagtga ctctccagaa attcctttcc aggctgctgc tggcccttct gatggcttag     4560

atgcctcctc tccaggaaat agctttgtag ggctccgtgt tgtagccaag tggtcatcca     4620

atggctactt ttactctggg aaaatcacac gagatgtcgg agctgggaag tataaattgc     4680

tctttgatga tgggtacgaa tgtgatgtgt tgggcaaaga cattctgtta tgtgacccca     4740

tcccgctgga cactgaagtg acggccctct cggaggatga gtatttcagt gcaggagtgg     4800

tgaaaggaca taggaaggag tctggggaac tgtactacag cattgaaaaa gaaggccaaa     4860

gaaagtggta taagcgaatg gctgtcatcc tgtccttgga gcaaggaaac agactgagag     4920

agcagtatgg gcttggcccc tatgaagcag taacacctct tacaaaggca gcagatatca     4980

gcttagacaa tttggtggaa gggaagcgga aacggcgcag taacgtcagc tccccagcca     5040

cccctactgc ctccagtagc agcagcacaa cccctacccg aaagatcaca gaaagtcctc     5100

gtgcctccat gggagttctc tcaggcaaaa gaaaacttat cacttctgaa gaggaacggt     5160

cccctgccaa gcgaggtcgc aagtctgcca cagtaaaacc tgtaggggca ggagagtttg     5220

tgagcccctg tgagagtgga gacaacaccg gtgaaccctc tgccctggaa gagcagagag     5280

ggcctttgcc tctcaacaag accttgtttc tgggctacgc atttctcctt accatggcca     5340

caaccagtga caagttggcc agccgctcca aactgccaga tggtcctaca ggaagcagtg     5400

aagaagagga ggaatttttg gaaattcctc ctttcaacaa gcagtataca gaatcccagc     5460

ttcgagcagg agctggctat atccttgaag atttcaatga agcccagtgt aacacagctt     5520

accagtgtct tctaattgcg gatcagcatt gtcgaacccg gaagtacttc ctgtgccttg     5580

ccagtgggat tccttgtgtg tctcatgtct gggtccatga tagttgccat gccaaccagc     5640

tccagaacta ccgtaattat ctgttgccag ctgggtacag ccttgaggag caaagaattc     5700

tggactggca accccgtgaa aatcctttcc agaatctgaa ggtactcttg gtatcagacc     5760

aacagcagaa cttcctggag ctctggtctg agatcctcat gactggtggt gcagcctctg     5820

tgaagcagca ccattcaagt gcccataaca aagatattgc tttaggggta tttgatgtgg     5880

tggtgacgga cccctcatgc ccagcctcgg tgctgaagtg tgctgaagca ttgcagctgc     5940

ctgtggtgtc acaagagtgg gtgatccagt gcctcattgt tggggagaga attggattca     6000

agcagcatcc aaaatataaa cacgattatg tttctcacta aagatacttg gtcttactgg     6060

ttttattccc tgctatcgtg gagattgtgt tttaaccagg ttttaaatgt gtcttgtgtg     6120

taactggatt ccttgcatgg atcttgtata tagttttatt tgctgaactt ttatgataaa     6180

ataaatgttg aatctctttg gttgtagtaa                                      6210


<210>  84
<211>  2728
<212>  DNA
<213>  Homo sapiens

<400>  84
gggccggagg gccgcggtgt gccgcggggc agttgcgggt tgtcataacg gtccccgccg       60

gagtgaggcg aggccgcgtc gctcagttct ggccgtctag ggcccctgta aggatgagag      120

cgcagaggac gcagggccgc tggaggcgca ggtaacgaag ctagggtgcg gttgggaccg      180

cggctgagct ttttccggga cccgtggtgc tgaatggaga ggacggagac gaagccgagc      240

cgcggctcct agcggcggcg ccgatgctcg agctgtagct gccaggcgag gatgtgtgga      300

gcgcaggcgg cgcggggtaa atgagaggtc tcgggcccca ggacccccgg ggcccgggat      360

gagttagcga gggcagccgc gggggccagt tccgaccgtg acaggccaag gcgacggccg      420

ccgcccgccc gccccttccg tgcagaagca gctgctcctt tccgcgcccg cccgcctgcg      480

ctcccggccc tggagaccat gaggttccgc atctacaaac ggaaggtgct aatcctgacg      540

ctcgtggtgg ccgcctgcgg cttcgtcctc tggagcagca atgggcgaca aaggaagaac      600

gaggccctcg ccccaccgtt gctggacgcc gaacccgcgc ggggtgccgg cggccgcggt      660

ggggaccacc cctctgtggc tgtgggcatc cgcagggtct ccaacgtgtc ggcggcttcc      720

ctggtcccgg cggtccccca gcccgaggcg gacaacctga cgctgcggta ccggtccctg      780

gtgtaccagc tgaactttga tcagaccctg aggaatgtag ataaggctgg cacctgggcc      840

ccccgggagc tggtgctggt ggtccaggtg cataaccggc ccgaatacct cagactgctg      900

ctggactcac ttcgaaaagc ccagggaatt gacaacgtcc tcgtcatctt tagccatgac      960

ttctggtcga ccgagatcaa tcagctgatc gccggggtga atttctgtcc ggttctgcag     1020

gtgttctttc ctttcagcat tcagttgtac cctaacgagt ttccaggtag tgaccctaga     1080

gattgtccca gagacctgcc gaagaatgcc gctttgaaat tggggtgcat caatgctgag     1140

tatcccgact ccttcggcca ttatagagag gccaaattct cccagaccaa acatcactgg     1200

tggtggaagc tgcattttgt gtgggaaaga gtgaaaattc ttcgagatta tgctggcctt     1260

atacttttcc tagaagagga tcactactta gccccagact tttaccatgt cttcaaaaag     1320

atgtggaaac tgaagcagca agagtgccct gaatgtgatg ttctctccct ggggacctat     1380

agtgccagtc gcagtttcta tggcatggct gacaaggtag atgtgaaaac ttggaaatcc     1440

acagagcaca atatgggtct agccttgacc cggaatgcct atcagaagct gatcgagtgc     1500

acagacactt tctgtactta tgatgattat aactgggact ggactcttca atacttgact     1560

gtatcttgtc ttccaaaatt ctggaaagtg ctggttcctc aaattcctag gatctttcat     1620

gctggagact gtggtatgca tcacaagaaa acctgtagac catccactca gagtgcccaa     1680

attgagtcac tcttaaataa taacaaacaa tacatgtttc cagaaactct aactatcagt     1740

gaaaagttta ctgtggtagc catttcccca cctagaaaaa atggagggtg gggagatatt     1800

agggaccatg aactctgtaa aagttataga agactgcagt gaaaatcaca gttacaaaag     1860

cgacagtctt ctatttttga tatttgtcca aacaggacat acaattgaat aaaagagttt     1920

aggaactggt ttctgcttta atacaaaaac aaaatcttgt aaaaggtgtc caaatacata     1980

gtaatctttt ccagttatgt ctgattaaga tttaaaactg aaggtttcat tttgggagta     2040

gggttttaaa gctcaatctg ttatctgcta aaattgatta ttgttgatat gagagaagag     2100

gggaaatttt atttaaattg catttattaa tctttttatc tgaaactttg tacacttttc     2160

cactttcaaa acctatttta agtacagcaa aatttattta aaactgtcat agcagtaaaa     2220

agtattacga tgaaattgtt agggtattaa tggaacaaac ccagtttcac tctcttgaca     2280

cacttattag gaagggattg cttcactggt ttaataattt aaaagttatg tttgttaaac     2340

accctgtcag aacagtcatt ttcagtatta gattcctgta ctattgtgtt ttgagtgtgt     2400

tttggaacct tcatagaaca cactttcttt tggaatgtat ttgattgata agaaagttta     2460

aacattgttt tcacctcaat gtagaaatac agtggttttg tttttttttt tcttttagtg     2520

ctgacaaaat aaaatactca tttttgcata aaaaggttcc taatcctttt gcagaataag     2580

ttttgtttac tctttatacc aaaattcagt gaaggcattc tacaagtttt gagttagcat     2640

tacattttaa tatttactat tgctacattg tataattgag tttgaaataa aacccagctt     2700

atgacaatgc aaaaaaaaaa aaaaaaaa                                        2728


<210>  85
<211>  5896
<212>  DNA
<213>  Homo sapiens

<400>  85
gcatgcgcag tgcgcagggc cggctcgaag cgcaagcagg aagcgtttgc ggtgatcccg       60

gcgactgcgc tggctaatgc ggtaccggct agcgtggctt ctgcaccccg cactgcccag      120

caccttccgc tcagtcctcg gcgcccgcct gccgcctccg gagcgcctgt gtggtttcca      180

aaaaaagact tacagcaaaa tgaataatcc agccatcaag agaataggaa atcacattac      240

caagtctcct gaagacaagc gagaatatcg agggctagag ctggccaatg gtatcaaagt      300

acttcttatc agtgatccca ccacggataa gtcatcagca gcacttgatg tgcacatagg      360

ttcattgtcg gatcctccaa atattgctgg cttaagtcat ttttgtgaac atatgctttt      420

tttgggaaca aagaaatacc ctaaagaaaa tgaatacagc cagtttctca gtgagcatgc      480

aggaagttca aatgccttta ctagtggaga gcataccaat tactattttg atgtttctca      540

tgaacaccta gaaggtgccc tagacaggtt tgcacagttt tttctgtgcc ccttgttcga      600

tgaaagttgc aaagacagag aggtgaatgc agttgattca gaacatgaga agaatgtgat      660

gaatgatgcc tggagactct ttcaattgga aaaagctaca gggaatccta aacacccctt      720

cagtaaattt gggacaggta acaaatatac tctggagact agaccaaacc aagaaggcat      780

tgatgtaaga caagagctac tgaaattcca ttctgcttac tattcatcca acttaatggc      840

tgtttgtgtt ttaggtcgag aatctttaga tgacttgact aatctggtgg taaagttatt      900

ttctgaagta gagaacaaaa atgttccatt gccagaattt cctgaacacc ctttccaaga      960

agaacatctt aaacaacttt acaaaatagt acccattaaa gatattagga atctctatgt     1020

gacatttccc atacctgacc ttcagaaata ctacaaatca aatcctggtc attatcttgg     1080

tcatctcatt gggcatgaag gtcctggaag tctgttatca gaacttaagt caaagggctg     1140

ggttaatact cttgttggtg ggcagaagga aggagcccga ggttttatgt tttttatcat     1200

taatgtggac ttgaccgagg aaggattatt acatgttgaa gatataattt tgcacatgtt     1260

tcaatacatt cagaagttac gtgcagaagg acctcaagaa tgggttttcc aagagtgcaa     1320

ggacttgaat gctgttgctt ttaggtttaa agacaaagag aggccacggg gctatacatc     1380

taagattgca ggaatattgc attattatcc cctagaagag gtgctcacag cggaatattt     1440

actggaagaa tttagacctg acttaataga gatggttctc gataaactca gaccagaaaa     1500

tgtccgggtt gccatagttt ctaaatcttt tgaaggaaaa actgatcgca cagaagagtg     1560

gtatggaacc cagtacaaac aagaagctat accggatgaa gtcatcaaga aatggcaaaa     1620

tgctgacctg aatgggaaat ttaaacttcc tacaaagaat gaatttattc ctacgaattt     1680

tgagatttta ccgttagaaa aagaggcgac accataccct gctcttatta aggatacagc     1740

tatgagcaaa ctttggttca aacaagatga taagtttttt ttgccgaagg cttgtctcaa     1800

ctttgaattt ttcagcccat ttgcttatgt ggaccccttg cactgtaaca tggcctattt     1860

gtaccttgag ctcctcaaag actcactcaa cgagtatgca tatgcagcag agctagcagg     1920

cttgagctat gatctccaaa ataccatcta tgggatgtat ctttcagtga aaggttacaa     1980

tgacaagcag ccaattttac taaagaagat tattgagaaa atggctacct ttgagattga     2040

tgaaaaaaga tttgaaatta tcaaagaagc atatatgcga tctcttaaca atttccgggc     2100

tgaacagcct caccagcatg ccatgtacta cctccgcttg ctgatgactg aagtggcctg     2160

gactaaagat gagttaaaag aagctctgga tgatgtaacc cttcctcgcc ttaaggcctt     2220

catacctcag ctcctgtcac ggctgcacat tgaagccctt ctccatggaa acataacaaa     2280

gcaggctgca ttaggaatta tgcagatggt tgaagacacc ctcattgaac atgctcatac     2340

caaacctctc cttccaagtc agctggttcg gtatagagaa gttcagctcc ctgacagagg     2400

atggtttgtt tatcagcaga gaaatgaagt tcacaataac tgtggcatcg agatatacta     2460

ccaaacagac atgcaaagca cctcagagaa tatgtttctg gagctcttct gtcagattat     2520

ctcggaacct tgcttcaaca ccctgcgcac caaggagcag ttgggctata tcgtcttcag     2580

cgggccacgt cgagctaatg gcatacaggg cttgagattc atcatccagt cagaaaagcc     2640

acctcactac ctagaaagca gagtggaagc tttcttaatt accatggaaa agtccataga     2700

ggacatgaca gaagaggcct tccaaaaaca cattcaggca ttagcaattc gtcgactaga     2760

caaaccaaag aagctatctg ctgagtgtgc taaatactgg ggagaaatca tctcccagca     2820

atataatttt gacagagata acactgaggt tgcatattta aagacactta ccaaggaaga     2880

tatcatcaaa ttctacaagg aaatgttggc agtagatgct ccaaggagac ataaggtatc     2940

cgtccatgtt cttgccaggg aaatggattc ttgtcctgtt gttggagagt tcccatgtca     3000

aaatgacata aatttgtcac aagcaccagc cttgccacaa cctgaagtga ttcagaacat     3060

gaccgaattc aagcgtggtc tgccactgtt tccccttgtg aaaccacata ttaacttcat     3120

ggctgcaaaa ctctgaagat tccccatgca tgggaaagtg caagtggatg cattcctgag     3180

tcttccagag cctaagaaaa tcatcttggc cactttaata gtttctgatt cactattaga     3240

gaaacaaaca aaaaattgtc aaatgtcatt atgtagaaat attataaatc caaagtaaat     3300

tacaaaatct tatagatgta gaatattttt taaatacatg cctcttaaat attttaaaat     3360

ttttcttttg attactgaga gaaatttccc caatataaca atgcttaaaa tgaatgatat     3420

tcctatagaa tcttccttcc ctattctgta aaatagtcac ttgtccgaag aaagttaaaa     3480

gttagctctt ttctaaaagc ctcctagctt gacatagaag gcttcacaac atttagaaag     3540

gtaataactt tttaaaaatt gatcctcaaa tttgctttct acttgatggt ttcatgtaaa     3600

tcagtggaaa acattacatt tggcagatga taaagcaatg tcatctttta ttagtgaaat     3660

gctggttata taaggcatgg ttttaatctt tttataaaat ttgaacatgt tttttatgcc     3720

aactcgtaaa atgctagaaa accctactta tttacaatgc tagaaataca gacttacctt     3780

acatcaattt tgtcctaaac cgaatttctc aggattactg tggtttcttt cattctgatt     3840

gaattatatt gacctacttc ttcatagttg gtttgcagtg ttccatgagt tttacttttc     3900

ctcatcaaca tattgcttta acacaacata tttatttaac acgtacaaat agggtcaact     3960

tcagatccta ctgagtgtgt gacatgcttt tccaacatca gctttttgta accacctgta     4020

taacttttta ttacagtgaa attgcagtca gtatgtgaac caaaatatct tgccccttta     4080

tgaatttaaa aggcagccaa tacaaagcca cctttttgga aatataaaaa gtaaagcctt     4140

gcattcttat atagcaggtc ttcataaaac tctaaaatcc cttgttgcta ccagtctaat     4200

cttgccttaa atgttaagtt attttttgaa tatataaata taaacatata aacacagatg     4260

atgactggag tagactttta aaaaaatatt tttttcatga gatactattt taggtgaaat     4320

tgttactgta gatttaacag ctgttttgaa atatttactg ttattaaaac ttgcttcaag     4380

agaaattgtg aatatatttc catatacaag cactagtaac agtaagtggc cctgtcatcc     4440

actaactcag gcaaagtaaa gaatggcatt tttgaaggac attttacctc cccatatgat     4500

ttgattggct aggactttct tctgtaaagt catacctttt cacatcttaa gtttttacat     4560

ttgccatttt ccaaatctca attttgggca agaacgatat agtcacaact atggggctgc     4620

tttcaaaagc ggggctccat ttctactgtc agatcaatgt ggtgctgtaa ccatcttttt     4680

atccctacct tcaagaacct ccttatatga agcctgtctt tatccatcag aaggtgtgtg     4740

aaatcatcac ttccttctgg ttttatgtat ttgtagacta tgcagctttt cattaaactg     4800

caagtatata caagacagat ctgaaattag gcctgagtgt tccgatccac cactgtacta     4860

gtaaataaaa atccacctac cttttatgtg gaaaattatg tgctattgag taacttttag     4920

ctctttttta aaaaatgggt gaaatttaag tgtctttttt atgagaatga cacatgaaga     4980

gatctgagag caatctcatg tagtcttcca tgaacctgca attgtttggt atgcgtcagc     5040

attttccaat ttccaggttg gatctagagc tgctgttgat cactcaggca tactaatgga     5100

ttcatttaga tgggtccaag ctgcagtcca tgagcaataa cagactaccc cagatactgc     5160

agtttacgca gtgcttagta aatgagattt gtggaactaa gttattagtt acctgaggct     5220

tcttaagaaa gtcttctttt ttgaccagtt gatgtgaaag agggagcatg tgacacagcc     5280

agtatggtgg agtgctaggg ttatcctgtt tacaataaat cgcctgaatt tcacctctgg     5340

agtctgcatt tgtattattt ttccagtttt agtgaaatag tacagtggcc agtcctcagc     5400

ctacctctca acatcccagt ttgaccagat ttcttgcttt cattgttcat aatgcagaaa     5460

gcagtgaatt atattaacat tttaaaagtg tttctgggta acaatgattt ttgtcaaata     5520

gaagactcaa tttcacaacc ttaagaatag atcacttttg taaaacaaga atctcagtat     5580

ttgatgttgg actccttgct gtgagtattg tcactgactc caaacccaga aagatttgtt     5640

cctgccctta cagggatgaa aataaaaagg atagaaaaaa tatttctctc ctctacaatg     5700

agtccttaca tcttcttgcc acatctccag ctgcagttta ggcagatatc ttgttcaatc     5760

tctgtcttct tgatccctgt caaaataatt tttctactca tatagtggcc agttggctca     5820

ggcaggcatt tcaagaggaa tctgcttgtt cctcactttt ccagcatagg acagtggtcc     5880

agcccgcaca gtcagc                                                     5896


<210>  86
<211>  8689
<212>  DNA
<213>  Homo sapiens

<400>  86
gccggcgccc taggaggcgg cggcgggagg atcgcgtccc gacccgaggc cgggcctgct       60

gcgcgccccc agcccgatcg gcaccgccac ttgcctgagc gccccggcgg cccgagcgcg      120

ccccaagccc gggcgccacc gctgccacct ccgcgaggtc tccctgagtc tttgaggaca      180

cagcctcgct ggaggcagtt tctggtgcca gtgacggggt ggcccgtgag ctgatgacga      240

ggactggctt ttaatccttg gtggtgatta agagaaagct tattggggcc tgggagcagc      300

tccccgccga cccccaccac catgtcggga tccacacagc ctgtggcaca gacgtggagg      360

gccactgagc cccgctaccc gccccacagc ctttcctacc cagtgcagat cgcccggacg      420

cacacggacg tcgggctcct ggagtaccag caccactccc gcgactatgc ctcccacctg      480

tcgcccggct ccatcatcca gccccagcgg cggaggccct ccctgctgtc tgagttccag      540

cccgggaatg aacggtccca ggagctccac ctgcggccag agtcccactc atacctgccc      600

gagctgggga agtcagagat ggagttcatt gaaagcaagc gccctcggct agagctgctg      660

cctgaccccc tgctgcgacc gtcacccctg ctggccacgg gccagcctgc gggatctgaa      720

gacctcacca aggaccgtag cctgacgggc aagctggaac cggtgtctcc ccccagcccc      780

ccgcacactg accctgagct ggagctggtg ccgccacggc tgtccaagga ggagctgatc      840

cagaacatgg accgcgtgga ccgagagatc accatggtag agcagcagat ctctaagctg      900

aagaagaagc agcaacagct ggaggaggag gctgccaagc cgcccgagcc tgagaagccc      960

gtgtcaccgc cgcccatcga gtcgaagcac cgcagcctgg tgcagatcat ctacgacgag     1020

aaccggaaga aggctgaagc tgcacatcgg attctggaag gcctggggcc ccaggtggag     1080

ctgccgctgt acaaccagcc ctccgacacc cggcagtatc atgagaacat caaaataaac     1140

caggcgatgc ggaagaagct aatcttgtac ttcaagagga ggaatcacgc tcggaaacaa     1200

tgggagcaga agttctgcca gcgctatgac cagctcatgg aggcctggga gaagaaggtg     1260

gagcgcatcg agaacaaccc ccggcggcgg gccaaggaga gcaaggtgcg cgagtactac     1320

gagaagcagt tccctgagat ccgcaagcag cgcgagctgc aggagcgcat gcagagggtg     1380

ggccagcggg gcagtgggct gtccatgtcg gccgcccgca gcgagcacga ggtgtcagag     1440

atcatcgatg gcctctcaga gcaggagaac ctggagaagc agatgcgcca gctggccgtg     1500

atcccgccca tgctgtacga cgctgaccag cagcgcatca agttcatcaa catgaacggg     1560

cttatggccg accccatgaa ggtgtacaaa gaccgccagg tcatgaacat gtggagtgag     1620

caggagaagg agaccttccg ggagaagttc atgcagcatc ccaagaactt tggcctgatc     1680

gcatcattcc tggagaggaa gacagtggct gagtgcgtcc tctattacta cctgactaag     1740

aagaatgaga actataagag cctggtgaga cggagctatc ggcgccgcgg caagagccag     1800

cagcagcaac aacagcagca gcagcagcag cagcagcagc agcagcagcc catgccccgc     1860

agcagccagg aggagaaaga tgagaaggag aaggaaaagg aggcggagaa ggaggaggag     1920

aagccggagg tggagaacga caaggaagac ctcctcaagg agaagacaga cgacacctca     1980

ggggaggaca acgacgagaa ggaggctgtg gcctccaaag gccgcaaaac tgccaacagc     2040

cagggaagac gcaaaggccg catcacccgc tcaatggcta atgaggccaa cagcgaggag     2100

gccatcaccc cccagcagag cgccgagctg gcctccatgg agctgaatga gagttctcgc     2160

tggacagaag aagaaatgga aacagccaag aaaggtctcc tggaacacgg ccgcaactgg     2220

tcggccatcg cccggatggt gggctccaag actgtgtcgc agtgtaagaa cttctacttc     2280

aactacaaga agaggcagaa cctcgatgag atcttgcagc agcacaagct gaagatggag     2340

aaggagagga acgcgcggag gaagaagaag aaagcgccgg cggcggccag cgaggaggct     2400

gcattcccgc ccgtggtgga ggatgaggag atggaggcgt cgggcgtgag cggaaatgag     2460

gaggagatgg tggaggaggc tgaagccact gtcaacaaca gctcagacac cgagagcatc     2520

ccctctcctc acactgaggc cgccaaggac acagggcaga atgggcccaa gcccccagcc     2580

accctgggcg ccgacgggcc acccccaggg ccacccaccc caccaccgga ggacatcccg     2640

gcccccactg agcccacccc ggcctctgaa gccaccggag cccctacgcc cccaccagca     2700

cccccatcgc cctctgcacc tcctcctgtg gtccccaagg aggagaagga ggaggagacc     2760

gcagcagcgc ccccagtgga ggagggggag gagcagaagc cccccgcggc tgaggagctg     2820

gcagtggaca cagggaaggc cgaggagccc gtcaagagcg agtgcacgga ggaagccgag     2880

gaggggccgg ccaagggcaa ggacgcggag gccgctgagg ccacggccga gggggcgctc     2940

aaggcagaga agaaggaggg cgggagcggc agggccacca cagccaagag ctcgggcgcc     3000

ccccaggaca gcgactccag tgctacctgc agtgcagacg aggtggatga ggccgagggc     3060

ggcgacaaga accggctgct gtccccaagg cccagcctcc tcaccccgac tggcgacccc     3120

cgggccaatg cctcacccca gaagccactg gacctgaagc agctgaagca gcgagcggct     3180

gccatccccc ccatccaggt caccaaagtc catgagcccc cccgggagga cgcagctccc     3240

accaagccag ctcccccagc cccaccgcca ccgcaaaacc tgcagccgga gagcgacgcc     3300

cctcagcagc ctggcagcag cccccggggc aagagcagga gcccggcacc ccccgccgac     3360

aaggaggcag agaagcctgt gttcttccca gccttcgcag ccgaggccca gaagctgcct     3420

ggggaccccc cttgctggac ttccggcctg cccttccccg tgcccccccg tgaggtgatc     3480

aaggcctccc cgcatgcccc ggacccctca gccttctcct acgctccacc tggtcaccca     3540

ctgcccctgg gcctccatga cactgcccgg cccgtcctgc cgcgcccacc caccatctcc     3600

aacccgcctc ccctcatctc ctctgccaag caccccagcg tcctcgagag gcaaataggt     3660

gccatctccc aaggaatgtc ggtccagctc cacgtcccgt actcagagca tgccaaggcc     3720

ccggtgggcc ctgtcaccat ggggctgccc ctgcccatgg accccaaaaa gctggcaccc     3780

ttcagcggag tgaagcagga gcagctgtcc ccacggggcc aggctgggcc accggagagc     3840

ctgggggtgc ccacagccca ggaggcgtcc gtgctgagag ggacagctct gggctcagtt     3900

ccgggcggaa gcatcaccaa aggcattccc agcacacggg tgccctcgga cagcgccatc     3960

acataccgcg gctccatcac ccacggcacg ccagctgacg tcctgtacaa gggcaccatc     4020

accaggatca tcggcgagga cagcccgagt cgcttggacc gcggccggga ggacagcctg     4080

cccaagggcc acgtcatcta cgaaggcaag aagggccacg tcttgtccta tgagggtggc     4140

atgtctgtga cccagtgctc caaggaggac ggcagaagca gctcaggacc cccccatgag     4200

acggccgccc ccaagcgcac ctatgacatg atggagggcc gcgtgggcag agccatctcc     4260

tcagccagca tcgaaggtct catgggccgt gccatcccgc cggagcgaca cagcccccac     4320

cacctcaaag agcagcacca catccgcggg tccatcacac aagggatccc tcggtcctac     4380

gtggaggcac aggaggacta cctgcgtcgg gaggccaagc tcctaaagcg ggagggcacg     4440

cctccgcccc caccgccctc acgggacctg accgaggcct acaagacgca ggccctgggc     4500

cccctgaagc tgaagccggc ccatgagggc ctggtggcca cggtgaagga ggcgggccgc     4560

tccatccatg agatcccgcg cgaggagctg cggcacacgc ccgagctgcc cctggccccg     4620

cggccgctca aggagggctc catcacgcag ggcaccccgc tcaagtacga caccggcgcg     4680

tccaccactg gctccaaaaa gcacgacgta cgctccctca tcggcagccc cggccggacg     4740

ttcccacccg tgcacccgct ggatgtgatg gccgacgccc gggcactgga acgtgcctgc     4800

tacgaggaga gcctgaagag ccggccaggg accgccagca gctcgggggg ctccattgcg     4860

cgcggcgccc cggtcattgt gcctgagctg ggtaagccgc ggcagagccc cctgacctat     4920

gaggaccacg gggcaccctt tgccggccac ctcccacgag gttcgcccgt gaccacgcgg     4980

gagcccacgc cgcgcctgca ggagggcagc ctttcgtcca gcaaggcatc ccaggaccga     5040

aagctgacgt cgacgcctcg tgagatcgcc aagtccccgc acagcaccgt gcccgagcac     5100

cacccacacc ccatctcgcc ctatgagcac ctgcttcggg gcgtgagtgg cgtggacctg     5160

tatcgcagcc acatccccct ggccttcgac cccacctcca taccccgcgg catccctctg     5220

gacgcagccg ctgcctacta cctgccccga cacctggccc ccaaccccac ctacccgcac     5280

ctgtacccac cctacctcat ccgcggctac cccgacacgg cggcgctgga gaaccggcag     5340

accatcatca atgactacat cacctcgcag cagatgcacc acaacgcggc caccgccatg     5400

gcccagcgag ctgatatgct gaggggcctc tcgccccgcg agtcctcgct ggcactcaac     5460

tacgctgcgg gtccccgagg catcatcgac ctgtcccaag tgccacacct gcctgtgctc     5520

gtgcccccga caccaggcac cccagccacc gccatggacc gccttgccta cctccccacc     5580

gcgccccagc ccttcagcag ccgccacagc agctccccac tctccccagg aggtccaaca     5640

cacttgacaa aaccaaccac cacgtcctcg tccgagcggg agcgagaccg ggatcgagag     5700

cgggaccggg atcgggagcg ggaaaagtcc atcctcacgt ccaccacgac ggtggagcac     5760

gcacccatct ggagacctgg tacagagcag agcagcggca gcagcggcgg gggtgggggc     5820

agcagcagcc gccccgcctc ccactcccat gcccaccagc actcgcccat ctcccctcgg     5880

acccaggatg ccctccagca gagacccagt gtgcttcaca acacaggcat gaagggtatc     5940

atcaccgctg tggagcccag cacgcccacg gtcctgaggt ccacctccac ctcctcaccc     6000

gttcgcccgg ctgccacatt cccacctgcc acccactgcc cactgggcgg caccctcgat     6060

ggggtctacc ctaccctcat ggagcccgtc ttgctgccca aggaggcccc ccgggtcgcc     6120

cggccagagc ggccccgagc agacaccggc catgccttcc tcgccaagcc cccagcccgc     6180

tccgggctgg agcccgcctc ctcccccagc aagggctcgg agccccggcc cctagtgcct     6240

cctgtctctg gccacgccac catcgcccgc acccctgcga agaacctcgc acctcaccac     6300

gccagcccgg acccgccggc gccacctgcc tcggcctcgg acccgcaccg ggaaaagact     6360

caaagtaaac ccttttccat ccaggaactg gaactccgtt ctctgggtta ccacggcagc     6420

agctacagcc ccgaaggggt ggagcccgtc agccctgtga gctcacccag tctgacccac     6480

gacaaggggc tccccaagca cctggaagag ctcgacaaga gccacctgga gggggagctg     6540

cggcccaagc agccaggccc cgtgaagctt ggcggggagg ccgcccacct cccacacctg     6600

cggccgctgc ctgagagcca gccctcgtcc agcccgctgc tccagaccgc cccaggggtc     6660

aaaggtcacc agcgggtggt caccctggcc cagcacatca gtgaggtcat cacacaggac     6720

tacacccggc accacccaca gcagctcagc gcacccctgc ccgcccccct ctactccttc     6780

cctggggcca gctgccccgt cctggacctc cgccgcccac ccagtgacct ctacctcccg     6840

cccccggacc atggtgcccc ggcccgtggc tccccccaca gcgaaggggg caagaggtct     6900

ccagagccaa acaagacgtc ggtcttgggt ggtggtgagg acggtattga acctgtgtcc     6960

ccaccggagg gcatgacgga gccagggcac tcccggagtg ctgtgtaccc gctgctgtac     7020

cgggatgggg aacagacgga gcccagcagg atgggctcca agtctccagg caacaccagc     7080

cagccgccag ccttcttcag caagctgacc gagagcaact ccgccatggt caagtccaag     7140

aagcaagaga tcaacaagaa gctgaacacc cacaaccgga atgagcctga atacaatatc     7200

agccagcctg ggacggagat cttcaatatg cccgccatca ccggaacagg ccttatgacc     7260

tatagaagcc aggcggtgca ggaacatgcc agcaccaaca tggggctgga ggccataatt     7320

agaaaggcac tcatgggtgg cggcgggaag gccaaggtct ctggcagacc cagcagccga     7380

aaagccaagt ccccggcccc gggcctggca tctggggacc ggccaccctc tgtctcctca     7440

gtgcactcgg agggagactg caaccgccgg acgccgctca ccaaccgcgt gtgggaggac     7500

aggccctcgt ccgcaggttc cacgccattc ccctacaacc ccctgatcat gcggctgcag     7560

gcgggtgtca tggcttcccc acccccaccg ggcctccccg cgggcagcgg gcccctcgct     7620

ggcccccacc acgcctggga cgaggagccc aagccactgc tctgctcgca gtacgagaca     7680

ctctccgaca gcgagtgact cagaacaggg cggggggggg ggcggtgtca ggtcccagcg     7740

agccacagga acggccctgc aggagcaggg cggctgccga ctcccccaac caaggaagga     7800

gcccctgagt ccgcctgcgc ctccatccat ctgtccgtcc agagccggca tccttgcctg     7860

tctaaagcct taactaagac tcccgccccg ggctggccct gtgcagacct tactcagggg     7920

atgtttacct ggtgctcggg aagggagggg aaggggccgg ggagggggca cggcaggcgt     7980

gtggcagcca cacgcaggcg gccagggcgg ccagggaccc aaagcaggat gaccacgcac     8040

ctccacgcca ctgcctcccc cgaatgcatt tggaaccaaa gtctaaactg agctcgcagc     8100

ccccgcgccc tccctccgcc tcccatcccg cttagcgctc tggacagatg gacgcaggcc     8160

ctgtccagcc cccagtgcgc tcgttccggt ccccacagac tgccccagcc aacgagattg     8220

ctggaaacca agtcaggcca ggtgggcgga caaaagggcc aggtgcggcc tggggggaac     8280

ggatgctccg aggactggac tgtttttttc acacatcgtt gccgcagcgg tgggaaggaa     8340

aggcagatgt aaatgatgtg ttggtttaca gggtatattt ttgatacctt caatgaatta     8400

attcagatgt tttacgcaag gaaggactta cccagtatta ctgctgctgt gcttttgatc     8460

tctgcttacc gttcaagagg cgtgtgcagg ccgacagtcg gtgaccccat cactcgcagg     8520

accaaggggg cggggactgc tggctcacgc cccgctgtgt cctccctccc tcccttcctt     8580

gggcagaatg aattcgatgc gtattctgtg gccgccatct gcgcagggtg gtggtattct     8640

gtcatttaca cacgtcgttc taattaaaaa gcgaattata ctccagtta                 8689


<210>  87
<211>  1276
<212>  DNA
<213>  Homo sapiens

<400>  87
attgagagga acaaagagct tataaataca ttaggacctg gaattcagtt gtcgagccag       60

gacggtgaca gcgtttaaca aagcttagag aaacctccag gagactgcta tcatggcaga      120

gaagcccaag ctccactact tcaatgcacg gggcagaatg gagtccaccc ggtggctcct      180

ggctgcagct ggagtagagt ttgaagagaa atttataaaa tctgcagaag atttggacaa      240

gttaagaaat gatggatatt tgatgttcca gcaagtgcca atggttgaga ttgatgggat      300

gaagctggtg cagaccagag ccattctcaa ctacattgcc agcaaataca acctctatgg      360

gaaagacata aaggagagag ccctgattga tatgtatata gaaggtatag cagatttggg      420

tgaaatgatc ctccttctgc ccgtatgtcc acctgaggaa aaagatgcca agcttgcctt      480

gatcaaagag aaaataaaaa atcgctactt ccctgccttt gaaaaagtct taaagagcca      540

tggacaagac taccttgttg gcaacaagct gagccgggct gacattcatc tggtggaact      600

tctctactac gtcgaggagc ttgactccag tcttatctcc agcttccctc tgctgaaggc      660

cctgaaaacc agaatcagca acctgcccac agtgaagaag tttctacagc ctggcagccc      720

aaggaagcct cccatggatg agaaatcttt agaagaagca aggaagattt tcaggtttta      780

ataacgcagt catggaggcc aagaacttgc aataccaatg ttctaaagtt ttgcaacaat      840

aaagtacttt acctaagtgt tgattgtgcc tgttgtgaag ctaatgaact ctttcaaatt      900

atatgctaat taaataatac aactcctatt cgctgactta gttaaaattg atttgttttc      960

attaggatct gatgtgaatt cagatttcca atcttctcct agccaaccat tttcctggaa     1020

ttaaaaattc agtaaaaaag gaaactatag attatgtggt ttgtttgact tttccaagaa     1080

ttgtcccgta acatacaatt tgtcatacaa tctattaaaa tgtcaatgta gaaatgcact     1140

tctgacattt tcaggtatgc acaggagaag agttaccatc ctggataatg gcataaagac     1200

attttcttct tttcctggac agtcatttta tttctgataa aagcgttctt tcttatgcaa     1260

aaaaaaaaaa aaaaaa                                                     1276


<210>  88
<211>  1535
<212>  DNA
<213>  Homo sapiens

<400>  88
cgcgtcgggc tgcaggagaa gatggcggtc tccacaggag ttaaagttcc tcgtaatttt       60

cgcttgttgg aagaacttga agaaggacaa aaaggagtag gcgacggtac agttagctgg      120

ggccttgaag atgatgaaga tatgacactt acaaggtgga caggcatgat tattgggcca      180

ccaaggacaa attatgaaaa cagaatatat agcctgaaag tagaatgtgg acctaaatac      240

ccagaagctc ctccgtcagt tagatttgta acaaaaatta atatgaacgg aataaataat      300

tccagtggga tggtggatgc ccggagcata ccagtgttag caaaatggca aaattcatat      360

agcattaaag ttgtacttca agagctaaga cgtctaatga tgtccaaaga aaatatgaag      420

cttccacagc caccagaagg acaaacatac aacaattaat tttagtggat ctcaaacttg      480

tcttaaatca acaaccttct actcatgtta atgtcttgat taaatatcac aatgcaaaat      540

acacattaag taaaagaatt ccagctggta aacatgacct ggacatttgt aagaatatat      600

ttaatatatg tacacccatt atgttttcag gtaacaggag gaaaaatgca gcacaatttt      660

ttttctcttg aaaggcactg tcatttaaac ataaacctgg agtactcgaa atagaattca      720

ggtttacaag atgaaagcgt gtggagaagt gtcagatggc agtggaagca tgtgtgtttc      780

taaaaagtaa aaatctcaag aaaacagaaa tggcatgctt tacccatctt acttagtgaa      840

agagagctgc agttgaaatt gtttaaaaag tagcaggtac aatgaatatt gtcacagatg      900

tgttaatttt tgaagcaatg tgggtgctga ctactagtag tatcaaaaat atgttcagga      960

ttgttttgat acctgtattt ataataaaaa atgttggggg gagttgatga attcctgtta     1020

aaagctgttc ttgtgtgtta catgtaacag acatggtaaa tatttgttta cagtctttgt     1080

ttaacaaacc atgcatttaa gtttaagtga agtcaacaaa aaggaaatag gtgtatggat     1140

atgtgatttt gagattaaag ttagtcttaa aatgtaaata aaatgtgaaa cgtgtcctca     1200

gagactgtgc catttctatt atgttgatgt atatgtacag taccttgcca gggaagcaaa     1260

aattggaatt attgtagctt ttcatgtata cacactttta tttaccctat tttgtgtact     1320

tcttgtgaat tataatttgc agactatttc agaaaagaaa ttatctagtt taatttcttc     1380

tttggacaag gagtcctagg tattatattt tgagtttgat ttcaccagaa ataataatat     1440

taaaaagatc tttgcattct ggcagttctt ttaggattat aggttgcaaa ttatccaaat     1500

atatatccca ttttttaaag cataaaaaaa aaaaa                                1535


<210>  89
<211>  7056
<212>  DNA
<213>  Homo sapiens

<400>  89
cacacccacg gcagacacgc acgcacccgg gcgccgaagg gaaagccgcg tctcgccctc       60

ccgccccgcc gtcggtcctg tctcagtccc tcagcagagc gggaaagcgg aggccggagc      120

cgtgacctct gaccccgtgg ttatgcggag ccgccgcatt ccttagcgat cgcggggcag      180

ccgccgctgc cgccgtgggc gactgacgca gcgcgggcgc gtggagccgc cgccgcccct      240

cccccaccgc cgctctcgcg ccagccggtc cccgcgtgcc cgccccttct ccccggccgc      300

acccgagacc tcgcgcgccg ccgctgccac gcgccccccc caccgccgcc gccgccccag      360

ccccgcgcca ccgccccagc ccgcccagcc cggaggtccc gcgtggagct gccgccgccg      420

ccggggagaa ggatgaagga caaacagaag aagaagaagg agcgcacgtg ggccgaggcc      480

gcgcgcctgg tattagaaaa ctactcggat gctccaatga caccaaaaca gattctgcag      540

gtcatagagg cagaaggact aaaggaaatg agaagtggga cttcccctct cgcatgcctc      600

aatgctatgc tacattccaa ttcaagagga ggagaggggt tgttttataa actgcctggc      660

cgaatcagcc ttttcacgct caagaaggat gccctgcagt ggtctcgcca tccagctaca      720

gtggagggag aggagccaga ggacacggct gatgtggaga gctgtgggtc taatgaagcc      780

agcactgtga gtggtgaaaa cgatgtatct cttgatgaaa catcttcgaa cgcatcctgt      840

tctacagaat ctcagagtcg acctctttcc aatcccaggg acagctacag agcttcctca      900

caggcgaaca aacaaaagaa aaagactggg gtgatgctgc ctcgagttgt cctgactcct      960

ctgaaggtaa acggggccca cgtggaatct gcatcagggt tctcgggctg ccacgccgat     1020

ggcgagagcg gcagcccgtc cagcagcagc agcggctctc tggccctggg cagcgctgct     1080

attcgtggcc aggccgaggt cacccaggac cctgccccgc tcctgagagg cttccggaag     1140

ccagccacag gtcaaatgaa gcgcaacaga ggggaagaaa tagattttga gacacctggg     1200

tccattcttg tcaacaccaa cctccgtgcc ctgatcaact ctcggacctt ccatgcctta     1260

ccatcacact tccagcagca gctcctcttc ctcctgcctg aagtagacag acaggtgggg     1320

acggatggcc tgttgcgtct cagcagcagt gcactaaata acgagttttt tacccatgcg     1380

gctcagagct ggcgggagcg cctggctgat ggtgaattta ctcatgagat gcaagtcagg     1440

atacgacagg aaatggagaa ggaaaagaag gtggaacaat ggaaagaaaa gttctttgaa     1500

gactactatg gacagaagct gggtttgacc aaagaagagt cattgcagca gaacgtgggc     1560

caggaggagg ctgaaatcaa aagtggcttg tgtgtcccag gagaatcagt gcgtatacag     1620

cgtggtccag ccacccgaca gcgagatggg cattttaaga aacgctctcg gccagatctc     1680

cgaaccagag ccagaaggaa tctgtacaaa aaacaggagt cagaacaagc aggggttgct     1740

aaggatgcaa aatctgtggc ctcagatgtt cccctctaca aggatgggga ggctaagact     1800

gacccagcag ggctgagcag tccccatctg ccaggcacat cctctgcagc acccgacctg     1860

gagggtcccg aattcccagt tgagtctgtg gcttctcgga tccaggctga gccagacaac     1920

ttggcacgtg cctctgcatc tccagacaga attcctagcc tgcctcagga aactgtggat     1980

caggaaccca aggatcagaa gaggaaatcc tttgagcagg cggcctctgc atcctttccc     2040

gaaaagaagc cccggcttga agatcgtcag tcctttcgta acacaattga aagtgttcac     2100

accgaaaagc cacagcccac taaagaggag cccaaagtcc cgcccatccg gattcaactt     2160

tcacgtatca aaccaccctg ggtggttaaa ggtcagccca cttaccagat atgcccccgg     2220

atcatcccca ccacggagtc ctcctgccgg ggttggactg gcgccaggac cctcgcagac     2280

attaaagccc gtgctctgca ggtccgaggg gcgagaggtc accactgcca tagagaggcg     2340

gccaccactg ccatcggagg ggggggtggc ccgggtggag gtggcggcgg ggccaccgat     2400

gagggaggtg gcagaggcag cagcagtggt gatggtggtg aggcctgtgg ccaccctgag     2460

cccaggggag gcccgagcac ccctggaaag tgtacgtcag atctacagcg aacacaacta     2520

ctgccgcctt atcctctaaa tggggagcat acccaggccg gaactgccat gtccagagct     2580

aggagagagg acctgccttc tctgagaaag gaggaaagct gcctactaca gagggctaca     2640

gttggactca cagatgggct aggagatgcc tcccaactcc ccgttgctcc cactggggac     2700

cagccatgcc aggccttgcc cctactgtcc tcccaaacct cagtagctga gagattagtg     2760

gagcagcctc agttgcatcc ggatgttaga actgaatgtg agtctggcac cacttcctgg     2820

gaaagtgatg atgaggagca aggacccacc gttcctgcag acaatggtcc cattccgtct     2880

ctagtgggag atgatacatt agagaaagga actggccaag ctcttgacag tcatcccact     2940

atgaaggatc ctgtaaatgt gacccccagt tccacacctg aatcctcacc gactgattgc     3000

ctgcagaaca gagcatttga tgacgaatta gggcttggtg gctcatgccc tcctatgagg     3060

gaaagtgata ctagacaaga aaacttgaaa accaaggctc tcgtttctaa cagttctttg     3120

cattggatac ccatcccatc gaatgatgag gtagtgaaac agcccaaacc agaatccaga     3180

gaacacatac catctgttga gccccaggtt ggagaggagt gggagaaagc tgctcccacc     3240

cctcctgcat tgcctgggga tttgacagct gaggagggtc tagatcctct tgacagcctt     3300

acttcactct ggactgtgcc atctcgagga ggcagtgaca gcaatggcag ttactgtcaa     3360

caggtggaca ttgaaaagct gaaaatcaac ggagactctg aagcactgag tcctcacggt     3420

gagtccacgg atacagcctc tgactttgaa ggtcacctca cggaggacag cagtgaggct     3480

gacactagag aagctgcagt gacaaaggga tcttcggtgg acaaggatga gaaacccaat     3540

tggaaccaat ctgccccact gtccaaggtg aatggtgaca tgcgtctggt tacaaggaca     3600

gatgggatgg ttgctcctca gagctgggtg tctcgagtat gtgcggtccg ccaaaagatc     3660

ccagattccc tactgctggc cagtactgag taccagccaa gagccgtgtg cctgtccatg     3720

cctgggtcct cagtggaggc cactaaccca cttgtgatgc agttgctgca gggtagcttg     3780

cccctagaga aggttcttcc accagcccac gatgacagca tgtcagaatc cccacaagta     3840

ccacttacaa aagaccagag ccatggctcg ctacgcatgg gatctttaca tggtcttgga     3900

aaaaacagtg gcatggttga tggaagcagc cccagttctt taagggcttt gaaggagcct     3960

cttctgccag atagctgtga aacaggcact ggtcttgcca ggattgaggc cacccaggct     4020

cctggagcac cccaaaagaa ttgcaaggca gtcccaagtt ttgactccct ccatccagtg     4080

acaaatccca ttacatcctc taggaaactg gaagaaatgg attccaaaga gcagttctct     4140

tcctttagtt gtgaagatca gaaggaagtc cgtgctatgt cacaggacag taattcaaat     4200

gctgctccag gaaagagccc aggagatctt actacctcga gaacacctcg tttctcatct     4260

ccaaatgtga tctcctttgg tccagagcag acaggtcggg ccctgggtga tcagagcaat     4320

gttacaggcc aagggaagaa gctttttggc tctgggaatg tggctgcaac ccttcagcgc     4380

cccaggcctg cggacccgat gcctcttcct gctgagatcc ctccagtttt tcccagtggg     4440

aagttgggac caagcacaaa ctccatgtct ggtggggtac agactccaag ggaagactgg     4500

gctccaaagc cacatgcctt tgttggcagc gtcaagaatg agaagacttt tgtggggggt     4560

cctcttaagg caaatgccga gaacaggaaa gctactgggc atagtcccct ggaactggtg     4620

ggtcacttgg aagggatgcc ctttgtcatg gacttgccct tctggaaatt accccgagag     4680

ccagggaagg ggctcagtga gcctctggag ccttcttctc tcccctccca actcagcatc     4740

aagcaggcat tttatgggaa gctttctaaa ctccaactga gttccaccag ctttaattat     4800

tcctctagct ctcccacctt tcccaaaggc cttgctggaa gtgtggtgca gctgagccac     4860

aaagcaaact ttggtgcgag ccacagtgca tcactttcct tgcaaatgtt cactgacagc     4920

agcacggtgg aaagcatctc gctccagtgt gcgtgcagcc tgaaagccat gatcatgtgc     4980

caaggctgcg gtgcgttctg tcacgatgac tgtattggac cctcaaagct ctgtgtattg     5040

tgccttgtgg tgagataata aattatggcc atgggaaaca ttgtatattt agtgtgtgta     5100

ttttgataat gattgatctt aaatctgtat acagaatatc attgatataa tactctttag     5160

gcaggagcac tcttgccttc ccccaaaatt tacactgcta aagccctctg tcacttggcg     5220

acccttctgg tcttgctgga ggggtttcct gggtataacc cattgggctg cccaaggcca     5280

gccagcctga gctctcctgc aagacagagc ctgatgtggc acggagtggg gttgcggggg     5340

gtggggggac tgcctgactc ccagagggac ttgaaactga agcaagaagg ttgcattctc     5400

caccaaggga gttaacctac ctgaactaag tagaaatgcc agtcttccac taccccctcc     5460

ctgccatctt ttcttctgct actttgggga gttgatggcc aggaaagaag ccagcacagg     5520

gttaaagtaa ctcctggcat tgcccaccag ggggctggtg cacctgctga cctcagggtc     5580

acagttgagt catttgccag ttgacggagc aagtttgacc ttggttctgt tgctgaagca     5640

aatttggaac ttttctgtct cagtgtgatc cactaaccca caggatcatt tggaaccttg     5700

aatagctctg cttggacaat ggggttgggg aatagggttg tctttcctat gaaaatgcca     5760

tctgtagacc ttgtgagtca gccgtccaga tgtttgcagg tgaattcctc tgcttgacat     5820

cctccctgtc actttggacc ctatgggagt gggcatctcc acgcacctgt gtatgtgaaa     5880

gtcattttac atttcaaagc agtgtgtgtt tcttattttt atatttttaa ctctttattc     5940

ttggatgtat aaagtgaact ttttggcttc tgtaagtatg ctctatgcac ctctaatgtt     6000

ttatcatgta tttatatgtt gtacacagta ctggctgatt ctgtaaatgg atgtattgta     6060

cagagaacat gaacgtctct tcctaatttt acatcttcag catcattgca ttaaagtggt     6120

gtaatctcct tctctacatc tgttgtcaga gccactgagt gctgtgctgc tcgacgtgag     6180

ggtgaaatga ttgacttgtg acctgccagg ttgcccgatg ccctgttggg tcaccggctg     6240

gacctgctgc agcctgcaga gccacagtca gcctgcccac atgccaccga gcaaacgcat     6300

cttgcttttc acatctctcc tcctacagcc ttaatggctg cttgctgcca tatgtgacaa     6360

atcaccacca ccagtgttaa gtgcttctgg attcatgggt gagttccctg ggcagccccc     6420

aggaaggcct tccagatctg gctccagggt caccacctgt cacagcaata cctgggacca     6480

tgctctcctg ggactgtgag gctccttttg acgtactttt gacatcaggc aggtttggga     6540

agaaacaaag ccatgcctgc tcctgcctct ctcccaacat gtttccagca agtagatgcc     6600

cctgtgtgtg ttttcccttg ccttgtttcc tgccttatat cttgtatttc gacttattac     6660

agagttgagg gttcttgctt aatttagatc aagtataaaa tttgtatgac ttcaagtctc     6720

attttatctg aaaggttttt ttctcattta atctgatgtg gcattttcgt catctgaagc     6780

atgagtgaca agttgggaat gatgtggtga tttagaatgc agtattggcc aagtccaagt     6840

tgtcaactta agcgtctgtt taccaaagac cgggaacagg ggcccaaaca tgtccagtcc     6900

tcttcttccc tctgctggaa cctttgggga cactcaaggg tacagtttga cactgatctg     6960

gtccatgagg ctgcccagag aaagcactgc ttctgtatgt ctcttgtggt attggaacaa     7020

taaacccgta caacctgcaa aaaaaaaaaa aaaaaa                               7056


<210>  90
<211>  7667
<212>  DNA
<213>  Homo sapiens

<400>  90
gtccgggttc gcttgcctcg tcagcgtccg cgtttttccc ggcccccccc aacccccccg       60

gacaggaccc ccttgagctt gtccctcagc tgccaccatg agcgaccaag atcactccat      120

ggatgaaatg acagctgtgg tgaaaattga aaaaggagtt ggtggcaata atgggggcaa      180

tggtaatggt ggtggtgcct tttcacaggc tcgaagtagc agcacaggca gtagcagcag      240

cactggagga ggagggcagg agtcccagcc atcccctttg gctctgctgg cagcaacttg      300

cagcagaatt gagtcaccca atgagaacag caacaactcc cagggcccga gtcagtcagg      360

gggaacaggt gagcttgacc tcacagccac acaactttca cagggtgcca atggctggca      420

gatcatctct tcctcctctg gggctacccc tacctcaaag gaacagagtg gcagcagtac      480

caatggcagc aatggcagtg agtcttccaa gaatcgcaca gtctctggtg ggcagtatgt      540

tgtggctgcc gctcccaact tacagaacca gcaagttctg acaggactac ctggagtgat      600

gcctaatatt cagtatcaag taatcccaca gttccagacc gttgatgggc aacagctgca      660

gtttgctgcc actggggccc aagtgcagca ggatggttct ggtcaaatac agatcatacc      720

aggtgcaaac caacagatta tcacaaatcg aggaagtgga ggcaacatca ttgctgctat      780

gccaaaccta ctccagcagg ctgtccccct ccaaggcctg gctaataatg tactctcagg      840

acagactcag tatgtgacca atgtaccagt ggccctgaat gggaacatca ccttgctacc      900

tgtcaacagc gtttctgcag ctaccttgac tcccagctct caggcagtca cgatcagcag      960

ctctgggtcc caggagagtg gctcacagcc tgtcacctca gggactacca tcagttctgc     1020

cagcttggta tcatcacaag ccagttccag ctcctttttc accaatgcca atagctactc     1080

aactactact accaccagca acatgggaat tatgaacttt actaccagtg gatcatcagg     1140

gaccaactct caaggccaga caccccagag ggtcagtggg ctacaggggt ctgatgctct     1200

gaacatccag caaaaccaga catctggagg ctcattgcaa gcaggccagc aaaaagaagg     1260

agagcaaaac cagcagacac agcagcaaca aattcttatc cagcctcagc tagttcaagg     1320

gggacaggcc ctccaggccc tccaagcagc accattgtca gggcagacct ttacaactca     1380

agccatctcc caggaaaccc tccagaacct ccagcttcag gctgttccaa actctggtcc     1440

catcatcatc cggacaccaa cagtggggcc caatggacag gtcagttggc agactctaca     1500

gctgcagaac ctccaagttc agaacccaca agcccaaaca atcaccttag ccccaatgca     1560

gggtgtttcc ttggggcaga ccagcagcag caacaccact ctcacaccca ttgcctcagc     1620

tgcttccatt cctgctggca cagtcactgt gaatgctgct caactctcct ccatgccagg     1680

cctccagacc attaacctca gtgcattggg tacttcagga atccaggtgc acccaattca     1740

aggcctgccg ttggctatag caaatgcccc aggtgatcat ggagctcagc ttggtctcca     1800

tggggctggt ggtgatggaa tacatgatga cacagcaggt ggagaggaag gagaaaacag     1860

cccagatgcc caaccccaag ccggtcggag gacccggcgg gaagcatgca cctgccccta     1920

ctgtaaagac agtgaaggaa ggggctcggg ggatcctggc aaaaagaaac agcatatttg     1980

ccacatccaa ggctgtggga aagtgtatgg caagacctct cacctgcggg cacacttgcg     2040

ctggcataca ggcgagaggc catttatgtg tacctggtca tactgtggga aacgcttcac     2100

acgttcggat gagctacaga ggcacaaacg tacacacaca ggtgagaaga aatttgcctg     2160

ccctgagtgt cctaagcgct tcatgaggag tgaccacctg tcaaaacata tcaagaccca     2220

ccagaataag aagggaggcc caggtgtagc tctgagtgtg ggcactttgc ccctggacag     2280

tggggcaggt tcagaaggca gtggcactgc cactccttca gcccttatta ccaccaatat     2340

ggtagccatg gaggccatct gtccagaggg cattgcccgt cttgccaaca gtggcatcaa     2400

cgtcatgcag gtggcagatc tgcagtccat taatatcagt ggcaatggct tctgagatca     2460

ggcacccggg gccagagaca tatgggccat accccttaac cccgggatgc aaggtagcat     2520

gggtccaaga gacatggaag agagagccat gaagcattaa aatgcatggt gttgagaaga     2580

atcaggagag ggatacaaga gaggagatgg ggtcccggca cccatctgta tcatcagtgc     2640

ctctttgaag gtgggaaaca ttagtgaaaa ttctgttggt gccacgcttt gatgagcatt     2700

tgtttgaccc cagtttcttc ttacacttct taccccagcc tacccttcct gcatttctct     2760

tctcagctct tccatgatgg attccccccc ctttcctaaa gccatcatgc cttgataaat     2820

atatatgatc attgaaatac tttttaacaa aaaacagatt ctatattatt atatatatat     2880

atatatatat aaagatatat agagatgcat tcacaggggt tggctgggag gaggaagacc     2940

attctgtgac caaaatacct tggtcatttt ttttatattg ccttatttcc ctatggctga     3000

gccttgttgt gacacatcaa gcttttctgt agatgttgtc ttggcttccc accagcttaa     3060

gcgttcatat gctctgcttt tagttcatat atacatacat aatgtttttc ctttcttaat     3120

tttgtctttt tgtttgggat cagcttcttg cactccttcc ctaactcaac tgttgccgtc     3180

tcatcttctc tcatctgatc acttcatgtt ttgtttttgt tactgcctgg atgaggcact     3240

tctgtcaatt ttttcaggac cttagttcca gcagcagaat ggaaaaatcc ttgaagccca     3300

ggctgatgct tgaagtaact gtggagggag tgttcaaaat actactgacg caggcacctt     3360

cttggcgctg gagagtcaaa ggcatctccc ttcattagct gctctgagca tcaagaatta     3420

gaagtctttc agtggaattg tacaagagtc cctttgaaga taataatctt ggctcagttt     3480

gtataaactg tcaaattttc aaataatagg tagggggctt tcactaggaa aatcatgtgc     3540

tcagaagagg aaatgactcg tagtcaggtt caggagttag tggagtattt ggactttggt     3600

actgctgtct tccaaggtag ctctaagttt tgatgtgtgg gcttctgagt ttatattctg     3660

aaaggaaata cacttctttt gaacatcccc actaggttct tttccattgt caataaggag     3720

catcagccag tgaatctgtt tcaggtttcc attctgcaga actcctccaa agcatgtgct     3780

agtggcaaga cagtggttct tatgatgttt tcccttaact tttccttgta tgttcttggg     3840

tggttcctaa gggaaaggga agcacatgat catgggaatg atagcccaga acaaaaagaa     3900

atcttgtctt accacagtgt tttataggag agattgggag aaatcatcct gttttctctg     3960

tgacctgatt tcagaagaga ctgatccaaa aattataacg gcagggaacc tagtgcattt     4020

ggcactgaga tttaaatgca accagaattg tcctcaaggc ccagccataa aagcattgtc     4080

tctctcgacc ttctggtatc ttgttagaga gcttttcact gtgaggaagt gtggaaaaat     4140

agctctgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtaatctgtt aggttgggga     4200

taggttttct gctagccaat attaaaagag acctgcaata aaaaaattac cctgatctga     4260

tagaaagcaa gtgtttttgt atgtgtgggt gaatgtgtgt tcatgcccgt atatgtctac     4320

acacagatga caaattatat ttgaaatcgt tggaaaataa attcagatca aaatgccttt     4380

caggcccatt acctagaaat ctatcttaaa acctgggtat gttcctaagg tcatttcttt     4440

gcttatgcta aattaattac aattatgaat ggaggatatt ctactgtact tttttaaaaa     4500

gaaactattt ttgtgtttga aagtgaaacc aacatccaga tctatagcag agtccttatt     4560

cttctcataa atctttttac tttggctaca aatagatgat ggtatgattc tattatatat     4620

tttatataaa atccatccaa attaagtttt gggtaagtgt gttgtttaat ctgaactata     4680

gtaacttaat actctaaaca atagttcact ccatttggtc ctttctccac agatgtaatt     4740

atgttttcaa ctcaggaact atggcaagga actttcccca gatcaaattc tattaacgct     4800

gagatacaag tcatccatgc acagccacta tcataccctt tattctcact gaaaggcaga     4860

actcagaacc tgttatttta tgtctgtaat catgtacttt ggcatctttt ggaggaaagg     4920

ggcaggataa ctcactggaa tgtacagtat tttgctagtg catttcaagg aatggaatct     4980

tctccagtat gaaattacca gatataaaat aatgtaatga tgctgaggat ataagctttt     5040

agaaggtaat ttgatggtat ttctttctcg aatgaaaagc tgctggttta ccctcaaccc     5100

tattcattag cattaccatg agtgaattta tatctaatta tttccacttg ccctgttctc     5160

ttcacaccaa ggaagctcca gatccagtat cttgtttggc ctcaaaacag aagcagcttc     5220

ttttgtctcc cagcagtagt gagccactca gtctcttcca caggaagttt ggagcctaca     5280

ttccttgagt caggagctta ttacagaaaa accccgtttc cctgaacttt tggctaacag     5340

aaattaattt aactgacatg catattgatt ctgaaatttt tttcctaagt ttttttcatt     5400

tttttgaatg agttttttaa attttttaga tgaccaaaac ttgcagggca ggggatgccc     5460

agaagagtgg tgagatagta aaacacttat tccctcatcc tttcaggttt tcaggttgcc     5520

catttatatt catttacatg tcatttgact gtctcacttt ttacccagaa cagtaacaac     5580

ccacaccgtc ttccttcagg gatttccaac tggcactctg tgggtgctac acagaatgca     5640

atttaatgga tatttctcag cctggttcag aataaattga tcctttgatc ccagaaagta     5700

tatactgaag tgtgggataa agattatgat taggggaggg ttggagacaa aagctgtaaa     5760

ttactatggc tgatttattt ctactatata catatatatt ttttgctttt gtatatccta     5820

tataggaaac taagcattgt atttttttta acaaatctaa aaaagcacta tgaactacag     5880

gtgtttgact ttcaaaatat attttgtatt gttaatatct tcacattgtg tgaatactgg     5940

aagctgcaga tctttgctag gacgcaataa atttatatac tttttgaggg gttcttctgg     6000

ggtgctaatc aggcccctgt tatgcttagg gggagccctg gtgctacttg cttgaagttt     6060

tcagtgtaag taccctgatg ccttttggac cttgggatca gatcaagagt tttggagatc     6120

aggtaccaag gaaataagga cagtctagct gcctcaagtg aggggccctt tgcatagctc     6180

tccttccccc tcactgaagc tgggtagcct attggggttg agagggaaaa tgtgaaatct     6240

cagaatttat ctcccttaga agagagccag taacttatgt acaaggatga aagaaaggtc     6300

gcagcagtag ctttggggaa agggaggaag atatggcact tctccaaccc cggaaaacat     6360

tgcttttgaa aactgctgat aaaatatgag ccggttatta cttctgtttg ggagactgtg     6420

ctctctgtgg tgcctctctt ggctctactc cacagatacc agacctcttc taagaggatg     6480

agcagaccag ctttgaggtt gacctgtttc tctttgtctg ccttcccaaa acaccagccc     6540

ccaggaagac attaagcagc cttaagctta aattcctact ccctcttcca aatttggctc     6600

acttgcctta gatccaaggc agggaaagga aaagaagggg ggtctctggc tttattactc     6660

ccctaagtct ttactctgac ttccccaaac ccagaaagat tttctccaca gtgttcattt     6720

gaaagaggag tattttgtcc cattttcccc ttcctcatta tcaaacagcc ccagtcttcc     6780

ttgtctctgc taagaaagta gaggcatgat gatctgcctc tcaactgccc taagtcctag     6840

ctaagtatca ggggaaaaaa aaaaaaaaaa agcctaacaa atgggattag actagggctg     6900

caagtagtga ggattttgtt gatacctctg ctgggatgtg tgctttccca tatcttgcct     6960

tcaggaatta cactgtgcct tttccccagg gatatgggct ctgtctaccc agtgctccag     7020

tttcccggta actgctcttg aacattgtgg acaagggcag gtcttcatat ttttgatcat     7080

ccctttctcc cagtgaaatc ccatagccct tacctagagt ctagggcaca aagacttcgg     7140

ggaagataca ctgagattga cctgaggaga catctacaca caccagtggc agctgcccca     7200

gggcctgctt ccccttccta agtctgtcat cctctggaag ggatgggtgg tgctccaatc     7260

tctggtgcct aaaaacccaa gtttatttct ctcttaacac tggcaataac cagtccacac     7320

cactgttgcc ttttaaaacc tcttaataat ctcatgctgt gtttgttttg attccaatcc     7380

aattatcacc agggctgtgt gggtaaatgc ttttaaatgc tctctcatct tgttcttccc     7440

cctcaccccc cactcttagg tatgtatgat gctaatcttg tccctaagta agtttcttcc     7500

tgctcctttt gtatcttcct ttcttgtctt tcctcctacc ttttgtctct tggtgttttg     7560

ggactttttt tttttttttt ttggcctttt gtacaaagat tagtttcaat gtagtctgta     7620

gcctcctttg taaaccaatt aaaaagtttt ttaataaaaa aaaaaaa                   7667


<210>  91
<211>  1679
<212>  DNA
<213>  Homo sapiens

<400>  91
gggaccggaa atcaagtcta caaggcgggg gggtgcacag atgaccggaa gcgtgccctg       60

gcggcgctgc cagccccagc tgggagctgg taggggagtg cgaggaaggc gggacgcagg      120

gcggagccgc tgcaggggcg gggcctgcgg acaggagccg gggtttgggg cgggaacccc      180

tcgtcccctg cagaccccgc ctgctcgggc gcgggcggcg gcgcggccat gaagctgaag      240

ctgaagaacg tgtttctcgc ctacttcctg gtgtcgatcg ccggcctcct ctacgcgctg      300

gtacagctcg gccagccatg tgactgcctt cctcccctgc gggcagcagc cgagcagcta      360

cggcagaagg atctgaggat ttcccagctg caagcggaac tccgacggcc accccctgcc      420

cctgcccagc cccctgaacc cgaggccctg cctactatct atgttgttac ccccacctat      480

gccaggctgg tacagaaggc agagctggta cgactgtccc agacactgag cctggtgccc      540

cggctgcatt ggctgctggt ggaggatgct gagggtccca ccccgctggt ctcagggctg      600

ctggctgcct ctggcctcct cttcacacac ctggtggtcc tcacgcccaa agcccagcgg      660

cttcgggagg gcgagcctgg ctgggttcat ccccgtggtg tcgagcagcg gaacaaggcc      720

ctggactggc tccggggcag agggggtgct gtgggtgggg agaaggaccc accaccacca      780

gggacccaag gagtcgtcta ctttgctgac gatgacaaca cctacagccg ggagctgttt      840

gaggagatgc gctggacccg tggtgtctca gtgtggcctg tggggctggt gggcggcctg      900

cgattcgagg gccctcaggt acaggacggc cgggtagtgg gcttccacac agcatgggag      960

cccagcaggc ccttccctgt ggatatggct ggatttgccg tggccctgcc cttgctgtta     1020

gataagccca atgcccaatt tgattccacc gctccccggg gccacctgga gagcagtctt     1080

ctgagccacc ttgtggatcc caaggacctg gagccacggg ctgccaactg cactcgggta     1140

ctggtgtggc atactcggac agagaagccc aagatgaagc aggaggagca gctgcagcgg     1200

cagggccggg gctcagaccc agcaattgag gtgtgatggc ggccccaccc caactaccac     1260

ctcttttcag gcacagacct tgtgggactg ggccccaggc ctgcccagga tgtggttttc     1320

caagtcctga cccttggagc cagaagtggc ccctctgccc ctccaggccc agggcatggt     1380

cctgctgctt cacccctccc ctagcctgcc gtgtggcact gcccacaggc tggggacaag     1440

cagcccttgt gttgagtcag gttggccctg tctagggtgg aacagaagga cagatggacc     1500

caggagggag ggcagctgag taactgggta acttattggg gctgggcatg cactgggggg     1560

ctggaggagc tgggctggac ccttcccacc tgagcatgct gacccccttc ctacctccag     1620

aataaagaat ctcaacctgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      1679


<210>  92
<211>  2267
<212>  DNA
<213>  Homo sapiens

<400>  92
gcggccgccg ccatcttcgc gcgcccgctc gccctaaccc cgcccccaga cgccatgccc       60

acgtgaccgc tcgcccccgg acccggagcg tgggcgggga tttcgtcacg tgacgttgcc      120

gcggggcggt gccaagatgg cgaggcccaa agaggtgagg agccggcagc gggggcggct      180

gtaactgtga ggaaggctgc agagtggcga cgtctacgcc gtaggttgga ggctgtgggg      240

ggtggccggg cgccagctcc caggccgcag aagtgacctg cggtggagtt ccctcctcgc      300

tgctggagaa cggagggaga aggttgctgg ccgggtgaaa gtgcctccct ctgcttgacg      360

gggctgaggg gcccgaagtc tagggcgtcc gtagtcgccc cggcctccgt gaagccccag      420

gtctagagat atgacccgag agtgcccatc tccggccccg gggcctgggg ctccgctgag      480

tggatcggtg ctggcagagg cggcagtagt gtttgcagtg gtgctgagca tccacgcaac      540

cgtatgggac cgatactcgt ggtgcgccgt ggccctcgca gtgcaggcct tctacgtcca      600

atacaagtgg gaccggctgc tacagcaggg aagcgccgtc ttccagttcc gaatgtccgc      660

aaacagtggc ctattgcccg cctccatggt catgcctttg cttggactag tcatgaagga      720

gcggtgccag actgctggga acccgttctt tgagcgtttt ggcattgtgg tggcagccac      780

tggcatggca gtggccctct tctcatcagt gttggcgctc ggcatcactc gcccagtgcc      840

aaccaacact tgtgtcatct tgggcttggc tggaggtgtt atcatttata tcatgaagca      900

ctcgttgagc gtgggggagg tgatcgaagt cctggaagtc cttctgatct tcgtttatct      960

caacatgatc ctgctgtacc tgctgccccg ctgcttcacc cctggtgagg cactgctggt     1020

attgggtggc attagctttg tcctcaacca gctcatcaag cgctctctga cactggtgga     1080

aagtcagggg gacccagtgg acttcttcct gctggtggtg gtagtaggga tggtactcat     1140

gggcattttc ttcagcactc tgtttgtctt catggactca ggcacctggg cctcctccat     1200

cttcttccac ctcatgacct gtgtgctgag ccttggtgtg gtcctaccct ggctgcaccg     1260

gctcatccgc aggaatcccc tgctctggct tcttcagttt ctcttccaga cagacacccg     1320

catctacctc ctagcctatt ggtctctgct ggccaccttg gcctgcctgg tggtgctgta     1380

ccagaatgcc aagcggtcat cttccgagtc caagaagcac caggccccca ccatcgcccg     1440

aaagtatttc cacctcattg tggtagccac ctacatccca ggtatcatct ttgaccggcc     1500

actgctctat gtagccgcca ctgtatgcct ggcggtcttc atcttcctgg agtatgtgcg     1560

ctacttccgc atcaagcctt tgggtcacac tctacggagc ttcctgtccc tttttctgga     1620

tgaacgagac agtggaccac tcattctgac acacatctac ctgctcctgg gcatgtctct     1680

tcccatctgg ctgatcccca gaccctgcac acagaagggt agcctgggag gagccagggc     1740

cctcgtcccc tatgccggtg tcctggctgt gggtgtgggt gatactgtgg cctccatctt     1800

cggtagcacc atgggggaga tccgctggcc tggaaccaaa aagacttttg aggggaccat     1860

gacatctata tttgcgcaga tcatttctgt agctctgatc ttaatctttg acagtggagt     1920

ggacctaaac tacagttatg cttggatttt ggggtccatc agcactgtgt ccctcctgga     1980

agcatacact acacagatag acaatctcct tctgcctctc tacctcctga tattgctgat     2040

ggcctagctg ttacagtgca gcagcagtga cggaggaaac agacatgggg agggtgaaca     2100

gtccccacag cagacagcta cttgggcatg aagagccaag gtgtgaaaag cagatttgat     2160

ttttcagttg attcagattt aaaataaaaa gcaaagctct cctaaaaaaa aaaaaaaaaa     2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   2267


<210>  93
<211>  3848
<212>  DNA
<213>  Homo sapiens

<400>  93
acctgcagcg cgaggcgcgc cgctccaggc ggcatcgcag ggctgggccg gcgcggcctg       60

gggaccccgg gctccggagg ccatgccggc gttggcgcgc gacggcggcc agctgccgct      120

gctcgttgtt ttttctgcaa tgatatttgg gactattaca aatcaagatc tgcctgtgat      180

caagtgtgtt ttaatcaatc ataagaacaa tgattcatca gtggggaagt catcatcata      240

tcccatggta tcagaatccc cggaagacct cgggtgtgcg ttgagacccc agagctcagg      300

gacagtgtac gaagctgccg ctgtggaagt ggatgtatct gcttccatca cactgcaagt      360

gctggtcgac gccccaggga acatttcctg tctctgggtc tttaagcaca gctccctgaa      420

ttgccagcca cattttgatt tacaaaacag aggagttgtt tccatggtca ttttgaaaat      480

gacagaaacc caagctggag aatacctact ttttattcag agtgaagcta ccaattacac      540

aatattgttt acagtgagta taagaaatac cctgctttac acattaagaa gaccttactt      600

tagaaaaatg gaaaaccagg acgccctggt ctgcatatct gagagcgttc cagagccgat      660

cgtggaatgg gtgctttgcg attcacaggg ggaaagctgt aaagaagaaa gtccagctgt      720

tgttaaaaag gaggaaaaag tgcttcatga attatttggg acggacataa ggtgctgtgc      780

cagaaatgaa ctgggcaggg aatgcaccag gctgttcaca atagatctaa atcaaactcc      840

tcagaccaca ttgccacaat tatttcttaa agtaggggaa cccttatgga taaggtgcaa      900

agctgttcat gtgaaccatg gattcgggct cacctgggaa ttagaaaaca aagcactcga      960

ggagggcaac tactttgaga tgagtaccta ttcaacaaac agaactatga tacggattct     1020

gtttgctttt gtatcatcag tggcaagaaa cgacaccgga tactacactt gttcctcttc     1080

aaagcatccc agtcaatcag ctttggttac catcgtagaa aagggattta taaatgctac     1140

caattcaagt gaagattatg aaattgacca atatgaagag ttttgttttt ctgtcaggtt     1200

taaagcctac ccacaaatca gatgtacgtg gaccttctct cgaaaatcat ttccttgtga     1260

gcaaaagggt cttgataacg gatacagcat atccaagttt tgcaatcata agcaccagcc     1320

aggagaatat atattccatg cagaaaatga tgatgcccaa tttaccaaaa tgttcacgct     1380

gaatataaga aggaaacctc aagtgctcgc agaagcatcg gcaagtcagg cgtcctgttt     1440

ctcggatgga tacccattac catcttggac ctggaagaag tgttcagaca agtctcccaa     1500

ctgcacagaa gagatcacag aaggagtctg gaatagaaag gctaacagaa aagtgtttgg     1560

acagtgggtg tcgagcagta ctctaaacat gagtgaagcc ataaaagggt tcctggtcaa     1620

gtgctgtgca tacaattccc ttggcacatc ttgtgagacg atccttttaa actctccagg     1680

ccccttccct ttcatccaag acaacatctc attctatgca acaattggtg tttgtctcct     1740

cttcattgtc gttttaaccc tgctaatttg tcacaagtac aaaaagcaat ttaggtatga     1800

aagccagcta cagatggtac aggtgaccgg ctcctcagat aatgagtact tctacgttga     1860

tttcagagaa tatgaatatg atctcaaatg ggagtttcca agagaaaatt tagagtttgg     1920

gaaggtacta ggatcaggtg cttttggaaa agtgatgaac gcaacagctt atggaattag     1980

caaaacagga gtctcaatcc aggttgccgt caaaatgctg aaagaaaaag cagacagctc     2040

tgaaagagag gcactcatgt cagaactcaa gatgatgacc cagctgggaa gccacgagaa     2100

tattgtgaac ctgctggggg cgtgcacact gtcaggacca atttacttga tttttgaata     2160

ctgttgctat ggtgatcttc tcaactatct aagaagtaaa agagaaaaat ttcacaggac     2220

ttggacagag attttcaagg aacacaattt cagtttttac cccactttcc aatcacatcc     2280

aaattccagc atgcctggtt caagagaagt tcagatacac ccggactcgg atcaaatctc     2340

agggcttcat gggaattcat ttcactctga agatgaaatt gaatatgaaa accaaaaaag     2400

gctggaagaa gaggaggact tgaatgtgct tacatttgaa gatcttcttt gctttgcata     2460

tcaagttgcc aaaggaatgg aatttctgga atttaagtcg tgtgttcaca gagacctggc     2520

cgccaggaac gtgcttgtca cccacgggaa agtggtgaag atatgtgact ttggattggc     2580

tcgagatatc atgagtgatt ccaactatgt tgtcaggggc aatgcccgtc tgcctgtaaa     2640

atggatggcc cccgaaagcc tgtttgaagg catctacacc attaagagtg atgtctggtc     2700

atatggaata ttactgtggg aaatcttctc acttggtgtg aatccttacc ctggcattcc     2760

ggttgatgct aacttctaca aactgattca aaatggattt aaaatggatc agccatttta     2820

tgctacagaa gaaatataca ttataatgca atcctgctgg gcttttgact caaggaaacg     2880

gccatccttc cctaatttga cttcgttttt aggatgtcag ctggcagatg cagaagaagc     2940

gatgtatcag aatgtggatg gccgtgtttc ggaatgtcct cacacctacc aaaacaggcg     3000

acctttcagc agagagatgg atttggggct actctctccg caggctcagg tcgaagattc     3060

gtagaggaac aatttagttt taaggacttc atccctccac ctatccctaa caggctgtag     3120

attaccaaaa caagattaat ttcatcacta aaagaaaatc tattatcaac tgctgcttca     3180

ccagactttt ctctagaagc tgtctgcgtt tactcttgtt ttcaaaggga cttttgtaaa     3240

atcaaatcat cctgtcacaa ggcaggagga gctgataatg aactttattg gagcattgat     3300

ctgcatccaa ggccttctca ggctggcttg agtgaattgt gtacctgaag tacagtatat     3360

tcttgtaaat acataaaaca aaagcatttt gctaaggaga agctaatatg attttttaag     3420

tctatgtttt aaaataatat gtaaattttt cagctattta gtgatatatt ttatgggtgg     3480

gaataaaatt tctactacag aattgcccat tattgaatta tttacatggt ataattaggg     3540

caagtcttaa ctggagttca cgaaccccct gaaattgtgc acccatagcc acctacacat     3600

tccttccaga gcacgtgtgc ttttacccca agatacaagg aatgtgtagg cagctatggt     3660

tgtcacagcc taagatttct gcaacaacag gggttgtatt gggggaagtt tataatgaat     3720

aggtgttcta ccataaagag taatacatca cctagacact ttggcggcct tcccagactc     3780

agggccagtc agaagtaaca tggaggatta gtattttcaa taaagttact cttgtcccca     3840

caaaaaaa                                                              3848


<210>  94
<211>  1805
<212>  DNA
<213>  Homo sapiens

<400>  94
caaatgcaga agtggttctc atcttttttt gcagcttaag atctgccttg gtatttgaag       60

agatataaac tagatcaatt tctttcacag gatcaactaa acagtgtacc acaatgaatt      120

ctgaacttga ctattatgaa aagtttgaag aagtccatgg gattctaatg tataaagatt      180

ttgtcaaata ttgggataat gtggaagcgt tccaggcaag accagatgat cttgtcattg      240

ccacctaccc taaatctggt acaacctggg ttagtgaaat tgtgtatatg atctataaag      300

agggtgatgt ggaaaagtgc aaagaagatg taatttttaa tcgaatacct ttcctggaat      360

gcagaaaaga aaacctcatg aatggagtaa aacaattaga tgagatgaat tctcctagaa      420

ttgtgaagac tcatttgcca cctgaacttc ttcctgcctc attttgggaa aaggattgta      480

agataatcta tctttgccgg aatgcaaagg atgtggctgt ttccttttat tatttctttc      540

taatggtggc tggtcatcca aatcctggat cctttccaga gtttgtggag aaattcatgc      600

aaggacaggt tccttatggt tcctggtata aacatgtaaa atcttggtgg gaaaagggaa      660

agagtccacg tgtactattt cttttctacg aagacctgaa agaggatatc agaaaagagg      720

tgataaaatt gatacatttc ctggaaagga agccatcaga ggagcttgtg gacaggatta      780

tacatcatac ttcgttccaa gagatgaaga acaatccatc cacaaattac acaacactgc      840

cagacgaaat tatgaaccag aaattgtcgc ccttcatgag aaagggaatt acaggagact      900

ggaaaaatca ctttacagta gccctgaatg aaaaatttga taaacattat gagcagcaaa      960

tgaaggaatc tacactgaag tttcgaactg agatctaaga aggtctttct ttacttaaca     1020

tatctgatat taaagatttc ttttcattat tctccacttt ttcttatttt agattgctag     1080

aaaagacata atcatggatt atgttgacat tttcttttta aatttttgtt taactttttt     1140

tttttttttt tgagacagag tctcactctg ttgcctaggc tggaggacag tggcacaatc     1200

atggctgatt gcagccttga cctccttgac tcaattgatc ctcccatctc agcctcccaa     1260

gtagctagga ctacagacat gtgcaaccat gtttggctaa tttttttaat gtttttttgt     1320

agagatgagg tcttattata ttgtccaggc tggtcttgaa ttcctgggct caagcttccc     1380

aagtagctgc aacaacaggc acacaccacc atgctcaact aattttattt ctattttttg     1440

tatagacagg ggcttgctat agtgtccagg ctggtctgaa acccttgagc tcaagtgatc     1500

ttcccacacc agcctcccaa aatactggga ttacaggctt gagcctccat gcctggccca     1560

ggtaacatgt ttattgagct gtacatgcat atgagaaata agaaactttt ttttcctact     1620

atcatctctt aaattttgtt ttctttttct tttgcttcct cttcttcttt tctatttttt     1680

ataaatatca tgcacaacta taacctatgg gaatgatgta gtaacacaga ttattcatct     1740

tgttagagtt gtattaaaaa taaacaagca tttcaaatta aaaaaaaaaa aaaaaaaaaa     1800

aaaaa                                                                 1805


<210>  95
<211>  4326
<212>  DNA
<213>  Homo sapiens

<400>  95
gcttgcggtg ggaggaggcg gctgaggcgg aaggacacac gaggctgctt cgttgcacac       60

ccgagaaagt ttcagccaaa cttcgggcgg cggctgaggc ggcggccgag gagcggcgga      120

ctcggggcgc ggggagtcga ggcatttgcg cctgggcttc ggagcgtagc gccagggcct      180

gagcctttga agcaggagga ggggaggaga gagtggggct cctctatcgg gaccccctcc      240

ccatgtggat ctgcccaggc ggcggcggcg gcggcggagg aggaggcgac cgagaagatg      300

cccgccctgc gccccgctct gctgtgggcg ctgctggcgc tctggctgtg ctgcgcggcc      360

cccgcgcatg cattgcagtg tcgagatggc tatgaaccct gtgtaaatga aggaatgtgt      420

gttacctacc acaatggcac aggatactgc aaatgtccag aaggcttctt gggggaatat      480

tgtcaacatc gagacccctg tgagaagaac cgctgccaga atggtgggac ttgtgtggcc      540

caggccatgc tggggaaagc cacgtgccga tgtgcctcag ggtttacagg agaggactgc      600

cagtactcaa catctcatcc atgctttgtg tctcgaccct gcctgaatgg cggcacatgc      660

catatgctca gccgggatac ctatgagtgc acctgtcaag tcgggtttac aggtaaggag      720

tgccaatgga cggatgcctg cctgtctcat ccctgtgcaa atggaagtac ctgtaccact      780

gtggccaacc agttctcctg caaatgcctc acaggcttca cagggcagaa atgtgagact      840

gatgtcaatg agtgtgacat tccaggacac tgccagcatg gtggcacctg cctcaacctg      900

cctggttcct accagtgcca gtgccctcag ggcttcacag gccagtactg tgacagcctg      960

tatgtgccct gtgcaccctc accttgtgtc aatggaggca cctgtcggca gactggtgac     1020

ttcacttttg agtgcaactg ccttccaggt tttgaaggga gcacctgtga gaggaatatt     1080

gatgactgcc ctaaccacag gtgtcagaat ggaggggttt gtgtggatgg ggtcaacact     1140

tacaactgcc gctgtccccc acaatggaca ggacagttct gcacagagga tgtggatgaa     1200

tgcctgctgc agcccaatgc ctgtcaaaat gggggcacct gtgccaaccg caatggaggc     1260

tatggctgtg tatgtgtcaa cggctggagt ggagatgact gcagtgagaa cattgatgat     1320

tgtgccttcg cctcctgtac tccaggctcc acctgcatcg accgtgtggc ctccttctct     1380

tgcatgtgcc cagaggggaa ggcaggtctc ctgtgtcatc tggatgatgc atgcatcagc     1440

aatccttgcc acaagggggc actgtgtgac accaaccccc taaatgggca atatatttgc     1500

acctgcccac aaggctacaa aggggctgac tgcacagaag atgtggatga atgtgccatg     1560

gccaatagca atccttgtga gcatgcagga aaatgtgtga acacggatgg cgccttccac     1620

tgtgagtgtc tgaagggtta tgcaggacct cgttgtgaga tggacatcaa tgagtgccat     1680

tcagacccct gccagaatga tgctacctgt ctggataaga ttggaggctt cacatgtctg     1740

tgcatgccag gtttcaaagg tgtgcattgt gaattagaaa taaatgaatg tcagagcaac     1800

ccttgtgtga acaatgggca gtgtgtggat aaagtcaatc gtttccagtg cctgtgtcct     1860

cctggtttca ctgggccagt ttgccagatt gatattgatg actgttccag tactccgtgt     1920

ctgaatgggg caaagtgtat cgatcacccg aatggctatg aatgccagtg tgccacaggt     1980

ttcactggtg tgttgtgtga ggagaacatt gacaactgtg accccgatcc ttgccaccat     2040

ggtcagtgtc aggatggtat tgattcctac acctgcatct gcaatcccgg gtacatgggc     2100

gccatctgca gtgaccagat tgatgaatgt tacagcagcc cttgcctgaa cgatggtcgc     2160

tgcattgacc tggtcaatgg ctaccagtgc aactgccagc caggcacgtc aggggttaat     2220

tgtgaaatta attttgatga ctgtgcaagt aacccttgta tccatggaat ctgtatggat     2280

ggcattaatc gctacagttg tgtctgctca ccaggattca cagggcagag atgtaacatt     2340

gacattgatg agtgtgcctc caatccctgt cgcaagggtg caacatgtat caacggtgtg     2400

aatggtttcc gctgtatatg ccccgaggga ccccatcacc ccagctgcta ctcacaggtg     2460

aacgaatgcc tgagcaatcc ctgcatccat ggaaactgta ctggaggtct cagtggatat     2520

aagtgtctct gtgatgcagg ctgggttggc atcaactgtg aagtggacaa aaatgaatgc     2580

ctttcgaatc catgccagaa tggaggaact tgtgacaatc tggtgaatgg atacaggtgt     2640

acttgcaaga agggctttaa aggctataac tgccaggtga atattgatga atgtgcctca     2700

aatccatgcc tgaaccaagg aacctgcttt gatgacataa gtggctacac ttgccactgt     2760

gtgctgccat acacaggcaa gaattgtcag acagtattgg ctccctgttc cccaaaccct     2820

tgtgagaatg ctgctgtttg caaagagtca ccaaattttg agagttatac ttgcttgtgt     2880

gctcctggct ggcaaggtca gcggtgtacc attgacattg acgagtgtat ctccaagccc     2940

tgcatgaacc atggtctctg ccataacacc cagggcagct acatgtgtga atgtccacca     3000

ggcttcagtg gtatggactg tgaggaggac attgatgact gccttgccaa tccttgccag     3060

aatggaggtt cctgtatgga tggagtgaat actttctcct gcctctgcct tccgggtttc     3120

actggggata agtgccagac agacatgaat gagtgtctga gtgaaccctg taagaatgga     3180

gggacctgct ctgactacgt caacagttac acttgcaagt gccaggcagg atttgatgga     3240

gtccattgtg agaacaacat caatgagtgc actgagagct cctgtttcaa tggtggcaca     3300

tgtgttgatg ggattaactc cttctcttgc ttgtgccctg tgggtttcac tggatccttc     3360

tgcctccatg agatcaatga atgcagctct catccatgcc tgaatgaggg aacgtgtgtt     3420

gatggcctgg gtacctaccg ctgcagctgc cccctgggct acactgggaa aaactgtcag     3480

accctggtga atctctgcag tcggtctcca tgtaaaaaca aaggtacttg cgttcagaaa     3540

aaagcagagt cccagtgcct atgtccatct ggatgggctg gtgcctattg tgacgtgccc     3600

aatgtctctt gtgacatagc agcctccagg agaggtgtgc ttgttgaaca cttgtgccag     3660

cactcaggtg tctgcatcaa tgctggcaac acgcattact gtcagtgccc cctgggctat     3720

actgggagct actgtgagga gcaactcgat gagtgtgcgt ccaacccctg ccagcacggg     3780

gcaacatgca gtgacttcat tggtggatac agatgcgagt gtgtcccagg ctatcagggt     3840

gtcaactgtg agtatgaagt ggatgagtgc cagaatcagc cctgccagaa tggaggcacc     3900

tgtattgacc ttgtgaacca tttcaagtgc tcttgcccac caggcactcg gggtatgaaa     3960

tcatccttat ccattttcca tccagggcat tgtcttaagt tataaatcca ttcttagtgt     4020

tcaggggatt ttataaaatt aaagatagga agactagctt cattccaagc atttagttct     4080

acatcctagt aattcaagcc attttattct cccatctctt gctagctctg atgttgtggt     4140

ttatgttgtc agttttatct ggttgtttgg catcttgata ttccatgaaa cacagaatat     4200

ggaagggata caacattagc ataacattaa aaaattagcc tggtcagtaa gatttcttgt     4260

tgcttcacag aaaagcaact aatggcctct aaaataaaca atttacattt aaaaaaaaaa     4320

aaaaaa                                                                4326


<210>  96
<211>  2478
<212>  DNA
<213>  Homo sapiens

<400>  96
ctggaacccg gaagcggcag cgcggcgcga cccggcgggc gggctctggg cgcgggaatc       60

ccggcggatc ccgggcgggc ggatgacccc cagccctacc cttggtgccg cctcctcctc      120

tctcctttct cctccggcag ccagcgcgcc tgtgtcctct ctaggaaggg gtaggggagg      180

ggcgtctgga gaggaccccc cgcgaatgcc cacgtgacgt gcagtccccc tggggctgtt      240

ccggcctgcg gggaacatgg gcgtgctcag ggtcggactg tgccctggcc ttaccgagga      300

gatgatccag cttctcagga gccacaggat caagacagtg gtggacctgg tttctgcaga      360

cctggaagag gtagctcaga aatgtggctt gtcttacaag acatggaggg cgcactcaag      420

tgggaacctg ggaggactgc agctgcctca ggtccccgca gggagatcgt ggagtggggt      480

caggaatgct ctgaagaagg caggacttgg gcatggagga acagatggac tttcgctgaa      540

tgctttcgat gaacgaggca ctgcggtcag cacttcacgt cttgataaac tgcttgatgc      600

tggtctctat actggagaag tgactgaaat tgtaggaggc ccaggtagcg gcaaaactca      660

ggtatgtctc tgtatggcag caaatgtggc ccatggcctg cagcaaaacg tcctatatgt      720

agattccaat ggagggctga cagcttcccg cctcctccag ctgcttcagg ctaaaaccca      780

ggatgaggag gaacaggcag aagctctccg gaggatccag gtggtgcatg catttgacat      840

cttccagatg ctggatgtgc tgcaggagct ccgaggcact gtggcccagc aggtgactgg      900

ttcttcagga actgtgaagg tggtggttgt ggactcggtc actgcggtgg tttccccact      960

tctgggaggt cagcagaggg aaggcttggc cttgatgatg cagctggccc gagagctgaa     1020

gaccctggcc cgggaccttg gcatggcagt ggtggtgacc aaccacataa ctcgagacag     1080

ggacagcggg aggctcaaac ctgccctcgg acgctcctgg agctttgtgc ccagcactcg     1140

gattctcctg gacaccatcg agggagcagg agcatcaggc ggccggcgca tggcgtgtct     1200

ggccaaatct tcccgacagc caacaggttt ccaggagatg gtagacattg ggacctgggg     1260

gacctcagag cagagtgcca cattacaggg tgatcagaca tgacctgtgc tgttgtttgg     1320

gaaacaggga agcattgggg acccctccca acttttcttc ccagtaacgc ctgctgttta     1380

ctgccacctg gcactggtga ctacagacgt tctcaggctg gccagaagag acatcttggg     1440

ttccttggcc tcactctctg taagcatata aaccacaggc gaaagaggat gctgcattgc     1500

gaggacccag aaattcatac tggtgccacg tttccttccc ttatttctaa cgtgtatgtt     1560

tctggtggaa accaagttca ccctggctgg gagcatctct gatgaggcat gctggcgact     1620

ggatggataa tcctgtgcat caccattgtg tcctgtgctc cctcctagcg cagtggccaa     1680

gccgggaaag cctctaactt gcctttgctg ctgctgcctt ttttttcttt tgtctctgcc     1740

tttccatttg ttagatgggg gcccactctt ccttagctct gtctctgagt tactgggtgg     1800

aaataagctt ataaatgaaa tactcttctt catctctgtt ttgctcttaa aaatataaaa     1860

aggcaattcc ccgagcccta gagccacctg atttcccctt agaaggctgt ttttcagttt     1920

cccccagtga ggcccaaaga acagtttatt cctcctttcc tcttgctgat ttggtttcag     1980

acctgcctgc atcaccatga ctaggtgaga acgtgtgggc tcgctgcagt tccagggata     2040

taatttaaca gaaagggagg gtatgacctg ctcctggtga atccagccac tcatttaata     2100

tgcatggtgc cctgtggggc ccctccacag tacagcataa ccagaggtgc tgaaccatgg     2160

ccttgcccat aaacagacag aggagaattt gcacagtaaa tagagccagc tgggaaaatt     2220

gatgctgacg taaataatac atggcaaatc tagtccttta tgcagaaatt cattgctggt     2280

ggctccaaga tgcaatataa ttacacctct cttcctgcca gctgtaccac agctagtgcc     2340

ctagtgtatg aaataatccc tctgtctttc accagcactg tggccatccg tctgagagcc     2400

atgaccctgg ctgggagggg acgaagacac cagggaatgg aaaataaaag gaaaagtaca     2460

gaaaaaaaaa aaaaaaaa                                                   2478


<210>  97
<211>  4258
<212>  DNA
<213>  Homo sapiens

<400>  97
agtgacgcag caggaggaaa ctgctcgggc tgcaagcagt cttccaggct ttgcggctgc       60

caaaggaata attgagacgt ctgagttgag caggtggaat gtcagaagac tgagaacatt      120

gttccttctt catactgctg ctctgttgcc agagaatccc aatttacact caaagcttct      180

ttgattaagt gctaggagat aaatttgcat tttctcaagg aaaaggctaa aagtggtagc      240

aggtggcatt taccgtcatg gagagcaggg atcataacaa cccccaggag ggacccacgt      300

cctccagcgg tagaagggct gcagtggaag acaatcactt gctgattaaa gctgttcaaa      360

acgaagatgt tgacctggtc cagcaattgc tggaaggtgg agccaatgtt aatttccagg      420

aagaggaagg gggctggaca cctctgcata acgcagtaca aatgagcagg gaggacattg      480

tggaacttct gcttcgtcat ggtgctgacc ctgttctgag gaagaagaat ggggccacgc      540

cttttatcct cgcagcgatt gcggggagcg tgaagctgct gaaacttttc ctttctaaag      600

gagcagatgt caatgagtgt gatttttatg gcttcacagc cttcatggaa gccgctgtgt      660

atggtaaggt caaagcccta aaattccttt ataagagagg agcaaatgtg aatttgaggc      720

gaaagacaaa ggaggatcaa gagcggctga ggaaaggagg ggccacagct ctcatggacg      780

ctgctgaaaa aggacacgta gaggtcttga agattctcct tgatgagatg ggggcagatg      840

taaacgcctg tgacaatatg ggcagaaatg ccttgatcca tgctctcctg agctctgacg      900

atagtgatgt ggaggctatt acgcatctgc tgctggacca tggggctgat gtcaatgtga      960

ggggagaaag agggaagact cccctgatcc tggcagtgga gaagaagcac ttgggtttgg     1020

tgcagaggct tctggagcaa gagcacatag agattaatga cacagacagt gatggcaaaa     1080

cagcactgct gcttgctgtt gaactcaaac tgaagaaaat cgccgagttg ctgtgcaaac     1140

gtggagccag tacagattgt ggggatcttg ttatgacagc gaggcggaat tatgaccatt     1200

cccttgtgaa ggttcttctc tctcatggag ccaaagaaga ttttcaccct cctgctgaag     1260

actggaagcc tcagagctca cactgggggg cagccctgaa ggatctccac agaatatacc     1320

gccctatgat tggcaaactc aagttcttta ttgatgaaaa atacaaaatt gctgatactt     1380

cagaaggagg catctacctg gggttctatg agaagcaaga agtagctgtg aagacgttct     1440

gtgagggcag cccacgtgca cagcgggaag tctcttgtct gcaaagcagc cgagagaaca     1500

gtcacttggt gacattctat gggagtgaga gccacagggg ccacttgttt gtgtgtgtca     1560

ccctctgtga gcagactctg gaagcgtgtt tggatgtgca cagaggggaa gatgtggaaa     1620

atgaggaaga tgaatttgcc cgaaatgtcc tgtcatctat atttaaggct gttcaagaac     1680

tacacttgtc ctgtggatac acccaccagg atctgcaacc acaaaacatc ttaatagatt     1740

ctaagaaagc tgctcacctg gcagattttg ataagagcat caagtgggct ggagatccac     1800

aggaagtcaa gagagatcta gaggaccttg gacggctggt cctctatgtg gtaaagaagg     1860

gaagcatctc atttgaggat ctgaaagctc aaagtaatga agaggtggtt caactttctc     1920

cagatgagga aactaaggac ctcattcatc gtctcttcca tcctggggaa catgtgaggg     1980

actgtctgag tgacctgctg ggtcatccct tcttttggac ttgggagagc cgctatagga     2040

cgcttcggaa tgtgggaaat gaatccgaca tcaaaacacg aaaatctgaa agtgagatcc     2100

tcagactact gcaacctggg ccttctgaac attccaaaag ttttgacaag tggacgacta     2160

agattaatga atgtgttatg aaaaaaatga ataagtttta tgaaaaaaga ggcaatttct     2220

accagaacac tgtgggtgat ctgctaaagt tcatccggaa tttgggagaa cacattgatg     2280

aagaaaagca taaaaagatg aaattaaaaa ttggagaccc ttccctgtat tttcagaaga     2340

catttccaga tctggtgatc tatgtctaca caaaactaca gaacacagaa tatagaaagc     2400

atttccccca aacccacagt ccaaacaagc ctcagtgtga tggagctggt ggggccagtg     2460

ggttggccag ccctgggtgc tgatggactg atttgctgga gttcagggaa ctacttatta     2520

gctgtagagt ccttggcaaa tcacaacatt ctgggccttt taactcacca ggttgcttgt     2580

gagggatgag ttgcatagct gatatgtcag tccctggcat cgtgtattcc atatgtctat     2640

aacaaaagca atatataccc agactacact agtccataag ctttacccac taactgggag     2700

gacattctgc taagattcct tttgtcaatt gcaccaaaag aatgagtgcc ttgaccccta     2760

atgctgcata tgttacaatt ctctcactta attttcccaa tgatcttgca aaacagggat     2820

tatcatcccc atttaagaac tgaggaacct gagactcaga gagtgtgagc tactggccca     2880

agattattca atttatacct agcactttat aaatttatgt ggtgttattg gtacctctca     2940

tttgggcacc ttaaaactta actatccttc cagggctctt ccagatgagg cccaaaacat     3000

atataggggt tccaggaatc tcattcattc attcagtatt tattgagcat ctagtataag     3060

tctgggcact ggatgcatga attccactcc ttccagaacc aactgcattg gttttccatg     3120

accttaaggc agtagttctc aactgggggg caattttgca ctgaagagag catttggcag     3180

agtctgaaga agtttttggt gtcacagctt tgtggggagc atgctatggc atttagtggg     3240

taaagaccag ggatgctgcc aaacctgcct tgcacaggac agcccctgca acaaagaatt     3300

atccagacaa aaatatcaat ggtgctgagg ttgagaaaac ctgacttaag gggctgggat     3360

gcttttgaac tagcttaagg cccaggactg tggagtgtgt ggaccacccc acagaggagg     3420

gactcagatt tatttactct tgctggatct gtagtgatgg agttccttct ggtgtcagcc     3480

ccacaggagg ctcccaggcc tccctcactt cccataccca gtctaggagc tccttctggc     3540

tcccaagcac ccagagcttt cctccgcctt ttagttttgg ttcctccact ggaatgtagg     3600

ctcctcacgg gcgatggctg tcttttcttg actttgtatc ttcactgcca agcaaaaagt     3660

ctgccaagtg ggaatgttta ataaatattc attgaataat gaatgaacca tcttcgtaca     3720

tgaataataa tactgtctta cgtttttctg gtgctttata atgtatacat tacatctgag     3780

tattttattt tatttaattt tcaaaacaat cctttaaggt caacattgtt atccttattt     3840

tgctgatgag gaaactaagg ttagaaacat tttgatttcc tctaggacgt atagctagga     3900

agtgttacta tcttgatttg aacaaatttt ctggtgctaa gtctgatgtt ctttccatga     3960

atcattgtgg tggttgagat ggagctttgt aatgggaata aaacagtacc ttaggttctt     4020

tctgaaaagg aggtatctag caatggataa atagatacca ctgaatgaaa ttaaatgttg     4080

attaggaaca aatttaaggc ttaaaaaata ctttatgagc agcaagattg ctttaacttt     4140

taaaatgaag ctttggttct ctgatttgta atgagcacct ggatatgtca attaaaatgc     4200

ccatttgtga agcttactca ataaaacttt aaattgtctt aaaaaaaaaa aaaaaaaa       4258


<210>  98
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Glu Lys Trp Tyr Leu Met Thr Val Val Val Leu Ile Gly Leu Thr 
1               5                   10                  15      


Val Arg Trp Thr Val Ser Leu Asn Ser Tyr Ser Gly Ala Gly Lys Pro 
            20                  25                  30          


Pro Met Phe Gly Asp Tyr Glu Ala Gln Arg His Trp Gln Glu Ile Thr 
        35                  40                  45              


Phe Asn Leu Pro Val Lys Gln Trp Tyr Phe Asn Ser Ser Asp Asn Asn 
    50                  55                  60                  


Leu Gln Tyr Trp Gly Leu Asp Tyr Pro Pro Leu Thr Ala Tyr His Ser 
65                  70                  75                  80  


Leu Leu Cys Ala Tyr Val Ala Lys Phe Ile Asn Pro Asp Trp Ile Ala 
                85                  90                  95      


Leu His Thr Ser Arg Gly Tyr Glu Ser Gln Ala His Lys Leu Phe Met 
            100                 105                 110         


Arg Thr Thr Val Leu Ile Ala Asp Leu Leu Ile Tyr Ile Pro Ala Val 
        115                 120                 125             


Val Leu Tyr Cys Cys Cys Leu Lys Glu Ile Ser Thr Lys Lys Lys Ile 
    130                 135                 140                 


Ala Asn Ala Leu Cys Ile Leu Leu Tyr Pro Gly Leu Ile Leu Ile Asp 
145                 150                 155                 160 


Tyr Gly His Phe Gln Tyr Asn Ser Val Ser Leu Gly Phe Ala Leu Trp 
                165                 170                 175     


Gly Val Leu Gly Ile Ser Cys Asp Cys Asp Leu Leu Gly Ser Leu Ala 
            180                 185                 190         


Phe Cys Leu Ala Ile Asn Tyr Lys Gln Met Glu Leu Tyr His Ala Leu 
        195                 200                 205             


Pro Phe Phe Cys Phe Leu Leu Gly Lys Cys Phe Lys Lys Gly Leu Lys 
    210                 215                 220                 


Gly Lys Gly Phe Val Leu Leu Val Lys Leu Ala Cys Ile Val Val Ala 
225                 230                 235                 240 


Ser Phe Val Leu Cys Trp Leu Pro Phe Phe Thr Glu Arg Glu Gln Thr 
                245                 250                 255     


Leu Gln Val Leu Arg Arg Leu Phe Pro Val Asp Arg Gly Leu Phe Glu 
            260                 265                 270         


Asp Lys Val Ala Asn Ile Trp Cys Ser Phe Asn Val Phe Leu Lys Ile 
        275                 280                 285             


Lys Asp Ile Leu Pro Arg His Ile Gln Leu Ile Met Ser Phe Cys Ser 
    290                 295                 300                 


Thr Phe Leu Ser Leu Leu Pro Ala Cys Ile Lys Leu Ile Leu Gln Pro 
305                 310                 315                 320 


Ser Ser Lys Gly Phe Lys Phe Thr Leu Val Ser Cys Ala Leu Ser Phe 
                325                 330                 335     


Phe Leu Phe Ser Phe Gln Val His Glu Lys Ser Ile Leu Leu Val Ser 
            340                 345                 350         


Leu Pro Val Cys Leu Val Leu Ser Glu Ile Pro Phe Met Ser Thr Trp 
        355                 360                 365             


Phe Leu Leu Val Ser Thr Phe Ser Met Leu Pro Leu Leu Leu Lys Asp 
    370                 375                 380                 


Glu Leu Leu Met Pro Ser Val Val Thr Thr Met Ala Phe Phe Ile Ala 
385                 390                 395                 400 


Cys Val Thr Ser Phe Ser Ile Phe Glu Lys Thr Ser Glu Glu Glu Leu 
                405                 410                 415     


Gln Leu Lys Ser Phe Ser Ile Ser Val Arg Lys Tyr Leu Pro Cys Phe 
            420                 425                 430         


Thr Phe Leu Ser Arg Ile Ile Gln Tyr Leu Phe Leu Ile Ser Val Ile 
        435                 440                 445             


Thr Met Val Leu Leu Thr Leu Met Thr Val Thr Leu Asp Pro Pro Gln 
    450                 455                 460                 


Lys Leu Pro Asp Leu Phe Ser Val Leu Val Cys Phe Val Ser Cys Leu 
465                 470                 475                 480 


Asn Phe Leu Phe Phe Leu Val Tyr Phe Asn Ile Ile Ile Met Trp Asp 
                485                 490                 495     


Ser Lys Ser Gly Arg Asn Gln Lys Lys Ile Ser 
            500                 505         


<210>  99
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Leu Lys Arg Ile Asn Lys Glu Leu Ser Asp Leu Ala Arg Asp 
1               5                   10                  15      


Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
            20                  25                  30          


Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
        35                  40                  45              


Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  


Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  


Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                85                  90                  95      


Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
            100                 105                 110         


Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
        115                 120                 125             


Thr Asp Arg Asp Lys Tyr Asn Arg Ile Ser Arg Glu Trp Thr Gln Lys 
    130                 135                 140                 


Tyr Ala Met 
145         


<210>  100
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


