                         SEQUENCE LISTING

<110>  Spring BioScience Corporation
 
<120>  ANTI-GPNMB ANTIBODIES AND DIAGNOSTIC USES THEREOF

<130>  P33057-WO

<150>  US 62/218,464
<151>  2015-09-14

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Ala Thr Thr Leu Lys Ser Tyr Asp Ser Asn Thr Pro Gly 
            340                 345                 350         


Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile Pro Asp Glu Asn 
        355                 360                 365             


Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr Ile Thr Ile Val 
    370                 375                 380                 


Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr Asp Val Leu Met 
385                 390                 395                 400 


Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe Val Val Thr Cys 
                405                 410                 415     


Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile Ser Asp Pro Thr 
            420                 425                 430         


Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val Asp Val Asp Glu 
        435                 440                 445             


Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly Ser Gly Thr Tyr 
    450                 455                 460                 


Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser Pro Leu Arg Met 
                485                 490                 495     


Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala Ile Phe Val Thr 
            500                 505                 510         


Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu Tyr Asn Pro Ile 
        515                 520                 525             


Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly Leu Ser Val Phe 
    530                 535                 540                 


Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn Gln Glu Lys Asp 
545                 550                 555                 560 


Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
                565                 570         


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of antibody heavy chain

<400>  2

Thr Tyr Gly Val Ile 
1               5   


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  3

Phe Ile Thr Arg Ser Gly Thr Thr Asp Tyr Ala Ala Trp Ala Asn Gly 
1               5                   10                  15      


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  4

Gly Gly Tyr Arg Phe Asn Leu 
1               5           


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  5

Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Ile Cys Thr Val Ser Gly Ile Asp Leu Ser 
            20                  25                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  6

Trp Val Arg Gln Ala Pro Arg Glu Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  7

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ala 
1               5                   10                  15      


Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  8

Trp Gly His Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  9

Gln Ala Ser Gln Ser Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  10

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  11

Gln Gly Gly Tyr Ile Ser Thr Thr Val Ser Phe Gly Tyr Gly 
1               5                   10                  


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  12

Asp Pro Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  13

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  14
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  14

Gly Val Pro Ser Arg Leu Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  15

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  16

Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Ile Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Tyr Gly 
            20                  25                  30          


Val Ile Trp Val Arg Gln Ala Pro Arg Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Thr Arg Ser Gly Thr Thr Asp Tyr Ala Ala Trp Ala Asn Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ala 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly 
                85                  90                  95      


Tyr Arg Phe Asn Leu Trp Gly His Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of a recombinant antibody

<400>  17

Asp Pro Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Leu Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Ile Ser Thr Thr 
                85                  90                  95      


Val Ser Phe Gly Tyr Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


