                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  INHIBITORS OF CYCLIN-DEPENDENT KINASES

<130>  D0504.70104WO00

<140>  PCT/US2016/051118
<141>  2016-09-09

<150>  US 62/216,271
<151>  2015-09-09

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
    210                 215                 220                 


Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


<210>  2
<211>  1490
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Asn Ser Glu Arg His Gly Gly Lys Lys Asp Gly Ser Gly Gly 
1               5                   10                  15      


Ala Ser Gly Thr Leu Gln Pro Ser Ser Gly Gly Gly Ser Ser Asn Ser 
            20                  25                  30          


Arg Glu Arg His Arg Leu Val Ser Lys His Lys Arg His Lys Ser Lys 
        35                  40                  45              


His Ser Lys Asp Met Gly Leu Val Thr Pro Glu Ala Ala Ser Leu Gly 
    50                  55                  60                  


Thr Val Ile Lys Pro Leu Val Glu Tyr Asp Asp Ile Ser Ser Asp Ser 
65                  70                  75                  80  


Asp Thr Phe Ser Asp Asp Met Ala Phe Lys Leu Asp Arg Arg Glu Asn 
                85                  90                  95      


Asp Glu Arg Arg Gly Ser Asp Arg Ser Asp Arg Leu His Lys His Arg 
            100                 105                 110         


His His Gln His Arg Arg Ser Arg Asp Leu Leu Lys Ala Lys Gln Thr 
        115                 120                 125             


Glu Lys Glu Lys Ser Gln Glu Val Ser Ser Lys Ser Gly Ser Met Lys 
    130                 135                 140                 


Asp Arg Ile Ser Gly Ser Ser Lys Arg Ser Asn Glu Glu Thr Asp Asp 
145                 150                 155                 160 


Tyr Gly Lys Ala Gln Val Ala Lys Ser Ser Ser Lys Glu Ser Arg Ser 
                165                 170                 175     


Ser Lys Leu His Lys Glu Lys Thr Arg Lys Glu Arg Glu Leu Lys Ser 
            180                 185                 190         


Gly His Lys Asp Arg Ser Lys Ser His Arg Lys Arg Glu Thr Pro Lys 
        195                 200                 205             


Ser Tyr Lys Thr Val Asp Ser Pro Lys Arg Arg Ser Arg Ser Pro His 
    210                 215                 220                 


Arg Lys Trp Ser Asp Ser Ser Lys Gln Asp Asp Ser Pro Ser Gly Ala 
225                 230                 235                 240 


Ser Tyr Gly Gln Asp Tyr Asp Leu Ser Pro Ser Arg Ser His Thr Ser 
                245                 250                 255     


Ser Asn Tyr Asp Ser Tyr Lys Lys Ser Pro Gly Ser Thr Ser Arg Arg 
            260                 265                 270         


Gln Ser Val Ser Pro Pro Tyr Lys Glu Pro Ser Ala Tyr Gln Ser Ser 
        275                 280                 285             


Thr Arg Ser Pro Ser Pro Tyr Ser Arg Arg Gln Arg Ser Val Ser Pro 
    290                 295                 300                 


Tyr Ser Arg Arg Arg Ser Ser Ser Tyr Glu Arg Ser Gly Ser Tyr Ser 
305                 310                 315                 320 


Gly Arg Ser Pro Ser Pro Tyr Gly Arg Arg Arg Ser Ser Ser Pro Phe 
                325                 330                 335     


Leu Ser Lys Arg Ser Leu Ser Arg Ser Pro Leu Pro Ser Arg Lys Ser 
            340                 345                 350         


Met Lys Ser Arg Ser Arg Ser Pro Ala Tyr Ser Arg His Ser Ser Ser 
        355                 360                 365             


His Ser Lys Lys Lys Arg Ser Ser Ser Arg Ser Arg His Ser Ser Ile 
    370                 375                 380                 


Ser Pro Val Arg Leu Pro Leu Asn Ser Ser Leu Gly Ala Glu Leu Ser 
385                 390                 395                 400 


Arg Lys Lys Lys Glu Arg Ala Ala Ala Ala Ala Ala Ala Lys Met Asp 
                405                 410                 415     


Gly Lys Glu Ser Lys Gly Ser Pro Val Phe Leu Pro Arg Lys Glu Asn 
            420                 425                 430         


Ser Ser Val Glu Ala Lys Asp Ser Gly Leu Glu Ser Lys Lys Leu Pro 
        435                 440                 445             


Arg Ser Val Lys Leu Glu Lys Ser Ala Pro Asp Thr Glu Leu Val Asn 
    450                 455                 460                 


Val Thr His Leu Asn Thr Glu Val Lys Asn Ser Ser Asp Thr Gly Lys 
465                 470                 475                 480 


Val Lys Leu Asp Glu Asn Ser Glu Lys His Leu Val Lys Asp Leu Lys 
                485                 490                 495     


Ala Gln Gly Thr Arg Asp Ser Lys Pro Ile Ala Leu Lys Glu Glu Ile 
            500                 505                 510         


Val Thr Pro Lys Glu Thr Glu Thr Ser Glu Lys Glu Thr Pro Pro Pro 
        515                 520                 525             


Leu Pro Thr Ile Ala Ser Pro Pro Pro Pro Leu Pro Thr Thr Thr Pro 
    530                 535                 540                 


Pro Pro Gln Thr Pro Pro Leu Pro Pro Leu Pro Pro Ile Pro Ala Leu 
545                 550                 555                 560 


Pro Gln Gln Pro Pro Leu Pro Pro Ser Gln Pro Ala Phe Ser Gln Val 
                565                 570                 575     


Pro Ala Ser Ser Thr Ser Thr Leu Pro Pro Ser Thr His Ser Lys Thr 
            580                 585                 590         


Ser Ala Val Ser Ser Gln Ala Asn Ser Gln Pro Pro Val Gln Val Ser 
        595                 600                 605             


Val Lys Thr Gln Val Ser Val Thr Ala Ala Ile Pro His Leu Lys Thr 
    610                 615                 620                 


Ser Thr Leu Pro Pro Leu Pro Leu Pro Pro Leu Leu Pro Gly Asp Asp 
625                 630                 635                 640 


Asp Met Asp Ser Pro Lys Glu Thr Leu Pro Ser Lys Pro Val Lys Lys 
                645                 650                 655     


Glu Lys Glu Gln Arg Thr Arg His Leu Leu Thr Asp Leu Pro Leu Pro 
            660                 665                 670         


Pro Glu Leu Pro Gly Gly Asp Leu Ser Pro Pro Asp Ser Pro Glu Pro 
        675                 680                 685             


Lys Ala Ile Thr Pro Pro Gln Gln Pro Tyr Lys Lys Arg Pro Lys Ile 
    690                 695                 700                 


Cys Cys Pro Arg Tyr Gly Glu Arg Arg Gln Thr Glu Ser Asp Trp Gly 
705                 710                 715                 720 


Lys Arg Cys Val Asp Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly 
                725                 730                 735     


Thr Tyr Gly Gln Val Tyr Lys Ala Lys Asp Lys Asp Thr Gly Glu Leu 
            740                 745                 750         


Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro 
        755                 760                 765             


Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln Leu Ile His Arg 
    770                 775                 780                 


Ser Val Val Asn Met Lys Glu Ile Val Thr Asp Lys Gln Asp Ala Leu 
785                 790                 795                 800 


Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met 
                805                 810                 815     


Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu Val His Phe Ser 
            820                 825                 830         


Glu Asp His Ile Lys Ser Phe Met Lys Gln Leu Met Glu Gly Leu Glu 
        835                 840                 845             


Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys Cys Ser Asn 
    850                 855                 860                 


Ile Leu Leu Asn Asn Ser Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu 
865                 870                 875                 880 


Ala Arg Leu Tyr Asn Ser Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val 
                885                 890                 895     


Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg 
            900                 905                 910         


Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile Leu Gly Glu 
        915                 920                 925             


Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Leu Glu Leu Ala Gln 
    930                 935                 940                 


Leu Glu Leu Ile Ser Arg Leu Cys Gly Ser Pro Cys Pro Ala Val Trp 
945                 950                 955                 960 


Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys 
                965                 970                 975     


Gln Tyr Arg Arg Arg Leu Arg Glu Glu Phe Ser Phe Ile Pro Ser Ala 
            980                 985                 990         


Ala Leu Asp Leu Leu Asp His Met  Leu Thr Leu Asp Pro  Ser Lys Arg 
        995                 1000                 1005             


Cys Thr  Ala Glu Gln Thr Leu  Gln Ser Asp Phe Leu  Lys Asp Val 
    1010                 1015                 1020             


Glu Leu  Ser Lys Met Ala Pro  Pro Asp Leu Pro His  Trp Gln Asp 
    1025                 1030                 1035             


Cys His  Glu Leu Trp Ser Lys  Lys Arg Arg Arg Gln  Arg Gln Ser 
    1040                 1045                 1050             


Gly Val  Val Val Glu Glu Pro  Pro Pro Ser Lys Thr  Ser Arg Lys 
    1055                 1060                 1065             


Glu Thr  Thr Ser Gly Thr Ser  Thr Glu Pro Val Lys  Asn Ser Ser 
    1070                 1075                 1080             


Pro Ala  Pro Pro Gln Pro Ala  Pro Gly Lys Val Glu  Ser Gly Ala 
    1085                 1090                 1095             


Gly Asp  Ala Ile Gly Leu Ala  Asp Ile Thr Gln Gln  Leu Asn Gln 
    1100                 1105                 1110             


Ser Glu  Leu Ala Val Leu Leu  Asn Leu Leu Gln Ser  Gln Thr Asp 
    1115                 1120                 1125             


Leu Ser  Ile Pro Gln Met Ala  Gln Leu Leu Asn Ile  His Ser Asn 
    1130                 1135                 1140             


Pro Glu  Met Gln Gln Gln Leu  Glu Ala Leu Asn Gln  Ser Ile Ser 
    1145                 1150                 1155             


Ala Leu  Thr Glu Ala Thr Ser  Gln Gln Gln Asp Ser  Glu Thr Met 
    1160                 1165                 1170             


Ala Pro  Glu Glu Ser Leu Lys  Glu Ala Pro Ser Ala  Pro Val Ile 
    1175                 1180                 1185             


Leu Pro  Ser Ala Glu Gln Thr  Thr Leu Glu Ala Ser  Ser Thr Pro 
    1190                 1195                 1200             


Ala Asp  Met Gln Asn Ile Leu  Ala Val Leu Leu Ser  Gln Leu Met 
    1205                 1210                 1215             


Lys Thr  Gln Glu Pro Ala Gly  Ser Leu Glu Glu Asn  Asn Ser Asp 
    1220                 1225                 1230             


Lys Asn  Ser Gly Pro Gln Gly  Pro Arg Arg Thr Pro  Thr Met Pro 
    1235                 1240                 1245             


Gln Glu  Glu Ala Ala Ala Cys  Pro Pro His Ile Leu  Pro Pro Glu 
    1250                 1255                 1260             


Lys Arg  Pro Pro Glu Pro Pro  Gly Pro Pro Pro Pro  Pro Pro Pro 
    1265                 1270                 1275             


Pro Pro  Leu Val Glu Gly Asp  Leu Ser Ser Ala Pro  Gln Glu Leu 
    1280                 1285                 1290             


Asn Pro  Ala Val Thr Ala Ala  Leu Leu Gln Leu Leu  Ser Gln Pro 
    1295                 1300                 1305             


Glu Ala  Glu Pro Pro Gly His  Leu Pro His Glu His  Gln Ala Leu 
    1310                 1315                 1320             


Arg Pro  Met Glu Tyr Ser Thr  Arg Pro Arg Pro Asn  Arg Thr Tyr 
    1325                 1330                 1335             


Gly Asn  Thr Asp Gly Pro Glu  Thr Gly Phe Ser Ala  Ile Asp Thr 
    1340                 1345                 1350             


Asp Glu  Arg Asn Ser Gly Pro  Ala Leu Thr Glu Ser  Leu Val Gln 
    1355                 1360                 1365             


Thr Leu  Val Lys Asn Arg Thr  Phe Ser Gly Ser Leu  Ser His Leu 
    1370                 1375                 1380             


Gly Glu  Ser Ser Ser Tyr Gln  Gly Thr Gly Ser Val  Gln Phe Pro 
    1385                 1390                 1395             


Gly Asp  Gln Asp Leu Arg Phe  Ala Arg Val Pro Leu  Ala Leu His 
    1400                 1405                 1410             


Pro Val  Val Gly Gln Pro Phe  Leu Lys Ala Glu Gly  Ser Ser Asn 
    1415                 1420                 1425             


Ser Val  Val His Ala Glu Thr  Lys Leu Gln Asn Tyr  Gly Glu Leu 
    1430                 1435                 1440             


Gly Pro  Gly Thr Thr Gly Ala  Ser Ser Ser Gly Ala  Gly Leu His 
    1445                 1450                 1455             


Trp Gly  Gly Pro Thr Gln Ser  Ser Ala Tyr Gly Lys  Leu Tyr Arg 
    1460                 1465                 1470             


Gly Pro  Thr Arg Val Pro Pro  Arg Gly Gly Arg Gly  Arg Gly Val 
    1475                 1480                 1485             


Pro Tyr  
    1490 


<210>  3
<211>  1512
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Ser Ser Ser Asp Thr Ala Leu Gly Gly Gly Gly Gly Leu Ser 
1               5                   10                  15      


Trp Ala Glu Lys Lys Leu Glu Glu Arg Arg Lys Arg Arg Arg Phe Leu 
            20                  25                  30          


Ser Pro Gln Gln Pro Pro Leu Leu Leu Pro Leu Leu Gln Pro Gln Leu 
        35                  40                  45              


Leu Gln Pro Pro Pro Pro Pro Pro Pro Leu Leu Phe Leu Ala Ala Pro 
    50                  55                  60                  


Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ser Cys 
65                  70                  75                  80  


Phe Ser Pro Gly Pro Pro Leu Glu Val Lys Arg Leu Ala Arg Gly Lys 
                85                  90                  95      


Arg Arg Ala Gly Gly Arg Gln Lys Arg Arg Arg Gly Pro Arg Ala Gly 
            100                 105                 110         


Gln Glu Ala Glu Lys Arg Arg Val Phe Ser Leu Pro Gln Pro Gln Gln 
        115                 120                 125             


Asp Gly Gly Gly Gly Ala Ser Ser Gly Gly Gly Val Thr Pro Leu Val 
    130                 135                 140                 


Glu Tyr Glu Asp Val Ser Ser Gln Ser Glu Gln Gly Leu Leu Leu Gly 
145                 150                 155                 160 


Gly Ala Ser Ala Ala Thr Ala Ala Thr Ala Ala Gly Gly Thr Gly Gly 
                165                 170                 175     


Ser Gly Gly Ser Pro Ala Ser Ser Ser Gly Thr Gln Arg Arg Gly Glu 
            180                 185                 190         


Gly Ser Glu Arg Arg Pro Arg Arg Asp Arg Arg Ser Ser Ser Gly Arg 
        195                 200                 205             


Ser Lys Glu Arg His Arg Glu His Arg Arg Arg Asp Gly Gln Arg Gly 
    210                 215                 220                 


Gly Ser Glu Ala Ser Lys Ser Arg Ser Arg His Ser His Ser Gly Glu 
225                 230                 235                 240 


Glu Arg Ala Glu Val Ala Lys Ser Gly Ser Ser Ser Ser Ser Gly Gly 
                245                 250                 255     


Arg Arg Lys Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Ser Arg Lys 
            260                 265                 270         


Asp Arg Asp Ser Lys Ala His Arg Ser Arg Thr Lys Ser Ser Lys Glu 
        275                 280                 285             


Pro Pro Ser Ala Tyr Lys Glu Pro Pro Lys Ala Tyr Arg Glu Asp Lys 
    290                 295                 300                 


Thr Glu Pro Lys Ala Tyr Arg Arg Arg Arg Ser Leu Ser Pro Leu Gly 
305                 310                 315                 320 


Gly Arg Asp Asp Ser Pro Val Ser His Arg Ala Ser Gln Ser Leu Arg 
                325                 330                 335     


Ser Arg Lys Ser Pro Ser Pro Ala Gly Gly Gly Ser Ser Pro Tyr Ser 
            340                 345                 350         


Arg Arg Leu Pro Arg Ser Pro Ser Pro Tyr Ser Arg Arg Arg Ser Pro 
        355                 360                 365             


Ser Tyr Ser Arg His Ser Ser Tyr Glu Arg Gly Gly Asp Val Ser Pro 
    370                 375                 380                 


Ser Pro Tyr Ser Ser Ser Ser Trp Arg Arg Ser Arg Ser Pro Tyr Ser 
385                 390                 395                 400 


Pro Val Leu Arg Arg Ser Gly Lys Ser Arg Ser Arg Ser Pro Tyr Ser 
                405                 410                 415     


Ser Arg His Ser Arg Ser Arg Ser Arg His Arg Leu Ser Arg Ser Arg 
            420                 425                 430         


Ser Arg His Ser Ser Ile Ser Pro Ser Thr Leu Thr Leu Lys Ser Ser 
        435                 440                 445             


Leu Ala Ala Glu Leu Asn Lys Asn Lys Lys Ala Arg Ala Ala Glu Ala 
    450                 455                 460                 


Ala Arg Ala Ala Glu Ala Ala Lys Ala Ala Glu Ala Thr Lys Ala Ala 
465                 470                 475                 480 


Glu Ala Ala Ala Lys Ala Ala Lys Ala Ser Asn Thr Ser Thr Pro Thr 
                485                 490                 495     


Lys Gly Asn Thr Glu Thr Ser Ala Ser Ala Ser Gln Thr Asn His Val 
            500                 505                 510         


Lys Asp Val Lys Lys Ile Lys Ile Glu His Ala Pro Ser Pro Ser Ser 
        515                 520                 525             


Gly Gly Thr Leu Lys Asn Asp Lys Ala Lys Thr Lys Pro Pro Leu Gln 
    530                 535                 540                 


Val Thr Lys Val Glu Asn Asn Leu Ile Val Asp Lys Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Val Ile Val Gly Lys Glu Ser Lys Ser Ala Ala Thr Lys Glu Glu 
                565                 570                 575     


Ser Val Ser Leu Lys Glu Lys Thr Lys Pro Leu Thr Pro Ser Ile Gly 
            580                 585                 590         


Ala Lys Glu Lys Glu Gln His Val Ala Leu Val Thr Ser Thr Leu Pro 
        595                 600                 605             


Pro Leu Pro Leu Pro Pro Met Leu Pro Glu Asp Lys Glu Ala Asp Ser 
    610                 615                 620                 


Leu Arg Gly Asn Ile Ser Val Lys Ala Val Lys Lys Glu Val Glu Lys 
625                 630                 635                 640 


Lys Leu Arg Cys Leu Leu Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro 
                645                 650                 655     


Gly Gly Asp Asp Leu Ser Lys Ser Pro Glu Glu Lys Lys Thr Ala Thr 
            660                 665                 670         


Gln Leu His Ser Lys Arg Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly 
        675                 680                 685             


Glu Thr Lys Glu Lys Asp Ile Asp Trp Gly Lys Arg Cys Val Asp Lys 
    690                 695                 700                 


Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr 
705                 710                 715                 720 


Lys Ala Arg Asp Lys Asp Thr Gly Glu Met Val Ala Leu Lys Lys Val 
                725                 730                 735     


Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu 
            740                 745                 750         


Ile Lys Ile Leu Arg Gln Leu Thr His Gln Ser Ile Ile Asn Met Lys 
        755                 760                 765             


Glu Ile Val Thr Asp Lys Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys 
    770                 775                 780                 


Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met Asp His Asp Leu Met Gly 
785                 790                 795                 800 


Leu Leu Glu Ser Gly Leu Val His Phe Asn Glu Asn His Ile Lys Ser 
                805                 810                 815     


Phe Met Arg Gln Leu Met Glu Gly Leu Asp Tyr Cys His Lys Lys Asn 
            820                 825                 830         


Phe Leu His Arg Asp Ile Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg 
        835                 840                 845             


Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser 
    850                 855                 860                 


Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg 
865                 870                 875                 880 


Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp 
                885                 890                 895     


Val Trp Ser Cys Gly Cys Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro 
            900                 905                 910         


Ile Phe Gln Ala Asn Gln Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg 
        915                 920                 925             


Ile Cys Gly Ser Pro Cys Pro Ala Val Trp Pro Asp Val Ile Lys Leu 
    930                 935                 940                 


Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu 
945                 950                 955                 960 


Arg Glu Glu Phe Val Phe Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp 
                965                 970                 975     


Tyr Met Leu Ala Leu Asp Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala 
            980                 985                 990         


Leu Gln Cys Glu Phe Leu Arg Asp  Val Glu Pro Ser Lys  Met Pro Pro 
        995                 1000                 1005             


Pro Asp  Leu Pro Leu Trp Gln  Asp Cys His Glu Leu  Trp Ser Lys 
    1010                 1015                 1020             


Lys Arg  Arg Arg Gln Lys Gln  Met Gly Met Thr Asp  Asp Val Ser 
    1025                 1030                 1035             


Thr Ile  Lys Ala Pro Arg Lys  Asp Leu Ser Leu Gly  Leu Asp Asp 
    1040                 1045                 1050             


Ser Arg  Thr Asn Thr Pro Gln  Gly Val Leu Pro Ser  Ser Gln Leu 
    1055                 1060                 1065             


Lys Ser  Gln Gly Ser Ser Asn  Val Ala Pro Val Lys  Thr Gly Pro 
    1070                 1075                 1080             


Gly Gln  His Leu Asn His Ser  Glu Leu Ala Ile Leu  Leu Asn Leu 
    1085                 1090                 1095             


Leu Gln  Ser Lys Thr Ser Val  Asn Met Ala Asp Phe  Val Gln Val 
    1100                 1105                 1110             


Leu Asn  Ile Lys Val Asn Ser  Glu Thr Gln Gln Gln  Leu Asn Lys 
    1115                 1120                 1125             


Ile Asn  Leu Pro Ala Gly Ile  Leu Ala Thr Gly Glu  Lys Gln Thr 
    1130                 1135                 1140             


Asp Pro  Ser Thr Pro Gln Gln  Glu Ser Ser Lys Pro  Leu Gly Gly 
    1145                 1150                 1155             


Ile Gln  Pro Ser Ser Gln Thr  Ile Gln Pro Lys Val  Glu Thr Asp 
    1160                 1165                 1170             


Ala Ala  Gln Ala Ala Val Gln  Ser Ala Phe Ala Val  Leu Leu Thr 
    1175                 1180                 1185             


Gln Leu  Ile Lys Ala Gln Gln  Ser Lys Gln Lys Asp  Val Leu Leu 
    1190                 1195                 1200             


Glu Glu  Arg Glu Asn Gly Ser  Gly His Glu Ala Ser  Leu Gln Leu 
    1205                 1210                 1215             


Arg Pro  Pro Pro Glu Pro Ser  Thr Pro Val Ser Gly  Gln Asp Asp 
    1220                 1225                 1230             


Leu Ile  Gln His Gln Asp Met  Arg Ile Leu Glu Leu  Thr Pro Glu 
    1235                 1240                 1245             


Pro Asp  Arg Pro Arg Ile Leu  Pro Pro Asp Gln Arg  Pro Pro Glu 
    1250                 1255                 1260             


Pro Pro  Glu Pro Pro Pro Val  Thr Glu Glu Asp Leu  Asp Tyr Arg 
    1265                 1270                 1275             


Thr Glu  Asn Gln His Val Pro  Thr Thr Ser Ser Ser  Leu Thr Asp 
    1280                 1285                 1290             


Pro His  Ala Gly Val Lys Ala  Ala Leu Leu Gln Leu  Leu Ala Gln 
    1295                 1300                 1305             


His Gln  Pro Gln Asp Asp Pro  Lys Arg Glu Gly Gly  Ile Asp Tyr 
    1310                 1315                 1320             


Gln Ala  Gly Asp Thr Tyr Val  Ser Thr Ser Asp Tyr  Lys Asp Asn 
    1325                 1330                 1335             


Phe Gly  Ser Ser Ser Phe Ser  Ser Ala Pro Tyr Val  Ser Asn Asp 
    1340                 1345                 1350             


Gly Leu  Gly Ser Ser Ser Ala  Pro Pro Leu Glu Arg  Arg Ser Phe 
    1355                 1360                 1365             


Ile Gly  Asn Ser Asp Ile Gln  Ser Leu Asp Asn Tyr  Ser Thr Ala 
    1370                 1375                 1380             


Ser Ser  His Ser Gly Gly Pro  Pro Gln Pro Ser Ala  Phe Ser Glu 
    1385                 1390                 1395             


Ser Phe  Pro Ser Ser Val Ala  Gly Tyr Gly Asp Ile  Tyr Leu Asn 
    1400                 1405                 1410             


Ala Gly  Pro Met Leu Phe Ser  Gly Asp Lys Asp His  Arg Phe Glu 
    1415                 1420                 1425             


Tyr Ser  His Gly Pro Ile Ala  Val Leu Ala Asn Ser  Ser Asp Pro 
    1430                 1435                 1440             


Ser Thr  Gly Pro Glu Ser Thr  His Pro Leu Pro Ala  Lys Met His 
    1445                 1450                 1455             


Asn Tyr  Asn Tyr Gly Gly Asn  Leu Gln Glu Asn Pro  Ser Gly Pro 
    1460                 1465                 1470             


Ser Leu  Met His Gly Gln Thr  Trp Thr Ser Pro Ala  Gln Gly Pro 
    1475                 1480                 1485             


Gly Tyr  Ser Gln Gly Tyr Arg  Gly His Ile Ser Thr  Ser Thr Gly 
    1490                 1495                 1500             


Arg Gly  Arg Gly Arg Gly Leu  Pro Tyr 
    1505                 1510         


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
ggcaggattg ccatgagttg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
ggcaagattg tcatgagtta                                                   20


