                               SEQUENCE LISTING

<110> THE BROAD INSTITUTE, INC.
      PRESIDENT AND FELLOWS OF HARVARD COLLEGE
      THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> METHODS OF IDENTIFYING DRUG-MODULATED POLYPEPTIDE TARGETS FOR 
      DEGRADATION

<130> 167741.011102/PCT

<140> PCT/US2016/051035
<141> 2016-09-09

<150> 62/258,929
<151> 2015-11-23

<150> 62/217,476
<151> 2015-09-11

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1
Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His 
            20              


<210> 2
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2
Phe Ala Cys Pro Tyr Cys Gly Ala Arg Asn Leu Asp Gln Gln Glu Leu 
1               5                   10                  15      


Val Lys His Cys Val Glu Ser His 
            20                  


<210> 3
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3
Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu 
1               5                   10                  15      


Asn Trp His Gln Arg Lys His 
            20              


<210> 4
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4
Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu 
1               5                   10                  15      


Asn Trp His Met Lys Lys His 
            20              


<210> 5
<211> 337
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys Asn Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Leu Met Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Lys Ala Ala Thr Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Thr Pro Thr Gly Lys Gln Thr Asp Lys Thr Lys Ser Asn Met Lys Gly 
                325                 330                 335     


Phe 
    


<210> 6
<211> 2661
<212> DNA
<213> Homo sapiens

<400> 6
atgcgcagct gggcggtgac agggtgacgc tcggagcgtg ggccgcgact ctcacggatc       60

cggttccgcc ctctcgctgc cgatccttcg gagcgagcgc ccgagatccc tttcccagag      120

tgctctgcgc cgtgaagaag cggctcccgg ggactggggg cattttgtgt tggctggagc      180

tggagtaaca agatggcgtc gtccgcggag tgacaggggt ccctctgggc cggagccggc      240

ggcagtggtg gcagcggtat cgccgcccta gctcaccgcg ccccttttcc agcccgcgac      300

gtcgccgcgc aagcgaggca gcggcggccg ccgagaaaca agtggcccag cctggtaacc      360

gccgagaagc ccttcacaaa ctgcggcctg gcaaaaagaa acctgactga gcggcggtga      420

tcaggttccc ctctgctgat tctgggcccc gaaccccggt aaaggcctcc gtgttccgtt      480

tcctgccgcc ctcctccgta gccttgccta gtgtaggagc cccgaggcct ccgtcctctt      540

cccagaggtg tcggggcttg gccccagcct ccatcttcgt ctctcaggat ggcgagtagc      600

agcggctcca aggctgaatt cattgtcgga gggaaatata aactggtacg gaagatcggg      660

tctggctcct tcggggacat ctatttggcg atcaacatca ccaacggcga ggaagtggca      720

gtgaagctag aatctcagaa ggccaggcat ccccagttgc tgtacgagag caagctctat      780

aagattcttc aaggtggggt tggcatcccc cacatacggt ggtatggtca ggaaaaagac      840

tacaatgtac tagtcatgga tcttctggga cctagcctcg aagacctctt caatttctgt      900

tcaagaaggt tcacaatgaa aactgtactt atgttagctg accagatgat cagtagaatt      960

gaatatgtgc atacaaagaa ttttatacac agagacatta aaccagataa cttcctaatg     1020

ggtattgggc gtcactgtaa taagtgttta gaatctccag tggggaagag gaaaagaagc     1080

atgactgtta gtacttctca ggacccatct ttctcaggat taaaccagtt attccttatt     1140

gattttggtt tggccaaaaa gtacagagac aacaggacaa ggcaacacat accatacaga     1200

gaagataaaa acctcactgg cactgcccga tatgctagca tcaatgcaca tcttggtatt     1260

gagcagagtc gccgagatga catggaatca ttaggatatg ttttgatgta ttttaataga     1320

accagcctgc catggcaagg gctaaaggct gcaacaaaga aacaaaaata tgaaaagatt     1380

agtgaaaaga agatgtccac gcctgttgaa gttttatgta aggggtttcc tgcagaattt     1440

gcgatgtact taaactattg tcgtgggcta cgctttgagg aagccccaga ttacatgtat     1500

ctgaggcagc tattccgcat tcttttcagg accctgaacc atcaatatga ctacacattt     1560

gattggacaa tgttaaagca gaaagcagca cagcaggcag cctcttccag tgggcagggt     1620

cagcaggccc aaacccccac aggcaagcaa actgacaaaa ccaagagtaa catgaaaggt     1680

ttctaagcat gaattgagga acagaagaag cagagcagat gatcggagca gcatttgttt     1740

ctccccaaat ctagaaattt tagttcatat gtacactagc cagtggttgt ggacaaccat     1800

ttacttggtg taaagaactt aatttcagta taaactgact ctgggcagca ttggtgatgc     1860

tgtatcctga gttgtagcct ctgtaattgt gaatattaac tgagatagtg aaacatggtg     1920

tccggttttc tattgcattt tttcaagtgg aaaagttaac taaatggttg acacacaaaa     1980

attggtggag aaattgtgca tatgccaatt ttttgttaaa accttttgtt ttgaactata     2040

ctgctttgag atctcatttc agaagaacgg catgaacagt cttcagccac agttgtgatg     2100

gttgttaaat gctcacaatt gtgcattctt agggtttttc catccctggg gtttgcaagt     2160

tgttcactta aaacattctt aaaatggttg gcttcttgtc tgcaagccag ctgatatggt     2220

agcaaccaaa gattccagtg tttgagcata tgaaagactc tgcctgctta attgtgctag     2280

aaataacagc atctaaagtg aagacttaag aaaaacttag tgactactag attatcctta     2340

ggactctgca ttaactctat aatgttcttg gtattaaaaa aaaagcatat ttgtcacaga     2400

aatttagtta acatcttaca actgaacatg tatgtatgtt gcttagataa atgtaatcac     2460

tgtaaacatc tatatgatct gggattttgt ttttattttg aaatgggagc ttttttgttt     2520

acaagttcat taaaaactaa aaactgtttc tgtaaggaaa tgagattttt tttaaacaac     2580

aaaaaatgcc ttgctgactc actattaaat aaaaatctcc ccaatttttt gatagactac     2640

ttcaaaaaaa aaaaaaaaaa a                                               2661


<210> 7
<211> 441
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Glu Ser Glu Glu Glu Asp Glu Met Glu Val 
            20                  25                  30          


Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn Phe 
        35                  40                  45              


Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met Glu 
    50                  55                  60                  


Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val Ile 
65                  70                  75                  80  


Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr Leu 
                85                  90                  95      


Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn Leu 
            100                 105                 110         


Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val Gln 
        115                 120                 125             


Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr Arg 
    130                 135                 140                 


Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile Gly 
145                 150                 155                 160 


Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly Ile 
                165                 170                 175     


Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr 
            180                 185                 190         


Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro 
        195                 200                 205             


Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln 
    210                 215                 220                 


Lys Tyr Gln Arg Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro 
225                 230                 235                 240 


Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile 
                245                 250                 255     


Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu 
            260                 265                 270         


Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro 
        275                 280                 285             


Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile 
    290                 295                 300                 


Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu 
305                 310                 315                 320 


Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile 
                325                 330                 335     


Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His 
            340                 345                 350         


Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn 
        355                 360                 365             


Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala 
    370                 375                 380                 


Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys 
385                 390                 395                 400 


Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu 
                405                 410                 415     


Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile 
            420                 425                 430         


Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440     


<210> 8
<211> 441
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Glu Ser Glu Glu Glu Asp Glu Met Glu Val 
            20                  25                  30          


Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn Phe 
        35                  40                  45              


Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met Glu 
    50                  55                  60                  


Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val Ile 
65                  70                  75                  80  


Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr Leu 
                85                  90                  95      


Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn Leu 
            100                 105                 110         


Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val Gln 
        115                 120                 125             


Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr Arg 
    130                 135                 140                 


Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile Gly 
145                 150                 155                 160 


Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly Ile 
                165                 170                 175     


Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr 
            180                 185                 190         


Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro 
        195                 200                 205             


Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln 
    210                 215                 220                 


Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro 
225                 230                 235                 240 


Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile 
                245                 250                 255     


Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu 
            260                 265                 270         


Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro 
        275                 280                 285             


Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile 
    290                 295                 300                 


Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu 
305                 310                 315                 320 


Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile 
                325                 330                 335     


Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His 
            340                 345                 350         


Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn 
        355                 360                 365             


Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala 
    370                 375                 380                 


Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys 
385                 390                 395                 400 


Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu 
                405                 410                 415     


Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile 
            420                 425                 430         


Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440     


<210> 9
<211> 2213
<212> DNA
<213> Homo sapiens

<400> 9
gcgtgtaaac agacatggcc ggcgaaggag atcagcagga cgctgcgcac aacatgggca       60

accacctgcc gctcctgcct gagagtgagg aagaagatga aatggaagtt gaagaccagg      120

atagtaaaga agccaaaaaa ccaaacatca taaattttga caccagtctg ccgacatcac      180

atacatacct aggtgctgat atggaagaat ttcatggcag gactttgcac gatgacgaca      240

gctgtcaggt gattccagtt cttccacaag tgatgatgat cctgattccc ggacagacat      300

tacctcttca gctttttcac cctcaagaag tcagtatggt gcggaattta attcagaaag      360

atagaacctt tgctgttctt gcatacagca atgtacagga aagggaagca cagtttggaa      420

caacagcaga gatatatgcc tatcgagaag aacaggattt tggaattgag atagtgaaag      480

tgaaagcaat tggaagacaa aggttcaaag tccttgagct aagaacacag tcagatggaa      540

tccagcaagc taaagtgcaa attcttcccg aatgtgtgtt gccttcaacc atgtctgcag      600

ttcaattaga atccctcaat aagtgccaga tatttccttc aaaacctgtc tcaagagaag      660

accaatgttc atataaatgg tggcagaaat accagaggag aaagtttcat tgtgcaaatc      720

taacttcatg gcctcgctgg ctgtattcct tatatgatgc tgagacctta atggacagaa      780

tcaagaaaca gctacgtgaa tgggatgaaa atctaaaaga tgattctctt ccttcaaatc      840

caatagattt ttcttacaga gtagctgctt gtcttcctat tgatgatgta ttgagaattc      900

agctccttaa aattggcagt gctatccagc gacttcgctg tgaattagac attatgaata      960

aatgtacttc cctttgctgt aaacaatgtc aagaaacaga aataacaacc aaaaatgaaa     1020

tattcagttt atccttatgt gggccgatgg cagcttatgt gaatcctcat ggatatgtgc     1080

atgagacact tactgtgtat aaggcttgca acttgaatct gataggccgg ccttctacag     1140

aacacagctg gtttcctggg tatgcctgga ctgttgccca gtgtaagatc tgtgcaagcc     1200

atattggatg gaagtttacg gccaccaaaa aagacatgtc acctcaaaaa ttttggggct     1260

taacgcgatc tgctctgttg cccacgatcc cagacactga agatgaaata agtccagaca     1320

aagtaatact ttgcttgtaa acagatgtga tagagataaa gttagttatc taacaaattg     1380

gttatattct aagatctgct ttggaaatta ttgcctctga tacataccta agtaaacata     1440

acattaatac ctaagtaaac ataacattac ttggagggtt gcagtttcta agtgaaactg     1500

tatttgaaac ttttaagtat actttaggaa acaagcatga acggcagtct agaataccag     1560

aaacatctac ttgggtagct tggtgccatt atcctgtgga atctgatatg tctggtagcg     1620

tgtcattgat gggacatgaa gacatctttg gaaatgatga gattatttcc tgtgttaaaa     1680

aaaaaaaaaa aatcttaaat tcctacaatg tgaaactgaa actaataatt tgatcctgat     1740

gtatgggaca gcgtatctgt accagtgctc taaataacaa aagctagggt gacaagtaca     1800

tgttcctttt ggaaagaagc aaggcaatgt atattaatta ttctaaaagg gctttgttcc     1860

tttccatttt ctttaacttc tctgagatac tgatttgtaa attttgaaaa ttagttaaaa     1920

tatgcagttt tttgagccca cgaatagttg tcatttcctt tatgtgcctg ttagtaaaaa     1980

gtagtattgt gtatttgctc agtatctgaa ctataagccc atttatactg ttccatacaa     2040

aagctatttt tcaaaaatta atttgaacca aaactactac tatagggaaa agatgccaaa     2100

acatgtcccc tcacccaggc taaacttgat actgtattat tttgttcaat gtaaattgaa     2160

gaaaatctgt aagtaagtaa accttaagtg tgaaactaaa aaaaaaaaaa aaa            2213


<210> 10
<211> 477
<212> PRT
<213> Homo sapiens

<400> 10
Met Asp Ala Asp Glu Gly Gln Asp Met Ser Gln Val Ser Gly Lys Glu 
1               5                   10                  15      


Ser Pro Pro Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro 
            20                  25                  30          


Ile Pro Glu Asp Leu Ser Thr Thr Ser Gly Gly Gln Gln Ser Ser Lys 
        35                  40                  45              


Ser Asp Arg Val Val Ala Ser Asn Val Lys Val Glu Thr Gln Ser Asp 
    50                  55                  60                  


Glu Glu Asn Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu 
65                  70                  75                  80  


Asp Leu Arg Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His 
                85                  90                  95      


Arg Asp Gln Gly Ser Ser Ala Leu Ser Gly Val Gly Gly Ile Arg Leu 
            100                 105                 110         


Pro Asn Gly Lys Leu Lys Cys Asp Ile Cys Gly Ile Ile Cys Ile Gly 
        115                 120                 125             


Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro 
    130                 135                 140                 


Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
145                 150                 155                 160 


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
                165                 170                 175     


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
            180                 185                 190         


Arg Thr His Ser Val Ile Lys Glu Glu Thr Asn His Ser Glu Met Ala 
        195                 200                 205             


Glu Asp Leu Cys Lys Ile Gly Ser Glu Arg Ser Leu Val Leu Asp Arg 
    210                 215                 220                 


Leu Ala Ser Asn Val Ala Lys Arg Lys Ser Ser Met Pro Gln Lys Phe 
225                 230                 235                 240 


Leu Gly Asp Lys Gly Leu Ser Asp Thr Pro Tyr Asp Ser Ser Ala Ser 
                245                 250                 255     


Tyr Glu Lys Glu Asn Glu Met Met Lys Ser His Val Met Asp Gln Ala 
            260                 265                 270         


Ile Asn Asn Ala Ile Asn Tyr Leu Gly Ala Glu Ser Leu Arg Pro Leu 
        275                 280                 285             


Val Gln Thr Pro Pro Gly Gly Ser Glu Val Val Pro Val Ile Ser Pro 
    290                 295                 300                 


Met Tyr Gln Leu His Lys Pro Leu Ala Glu Gly Thr Pro Arg Ser Asn 
305                 310                 315                 320 


His Ser Ala Gln Asp Ser Ala Val Glu Asn Leu Leu Leu Leu Ser Lys 
                325                 330                 335     


Ala Lys Leu Val Pro Ser Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys 
            340                 345                 350         


Gln Asp Ser Thr Asp Thr Glu Ser Asn Asn Glu Glu Gln Arg Ser Gly 
        355                 360                 365             


Leu Ile Tyr Leu Thr Asn His Ile Ala Pro His Ala Arg Asn Gly Leu 
    370                 375                 380                 


Ser Leu Lys Glu Glu His Arg Ala Tyr Asp Leu Leu Arg Ala Ala Ser 
385                 390                 395                 400 


Glu Asn Ser Gln Asp Ala Leu Arg Val Val Ser Thr Ser Gly Glu Gln 
                405                 410                 415     


Met Lys Val Tyr Lys Cys Glu His Cys Arg Val Leu Phe Leu Asp His 
            420                 425                 430         


Val Met Tyr Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe 
        435                 440                 445             


Glu Cys Asn Met Cys Gly Tyr His Ser Gln Asp Arg Tyr Glu Phe Ser 
    450                 455                 460                 


Ser His Ile Thr Arg Gly Glu His Arg Phe His Met Ser 
465                 470                 475         


<210> 11
<211> 519
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Ala Asp Glu Gly Gln Asp Met Ser Gln Val Ser Gly Lys Glu 
1               5                   10                  15      


Ser Pro Pro Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro 
            20                  25                  30          


Ile Pro Glu Asp Leu Ser Thr Thr Ser Gly Gly Gln Gln Ser Ser Lys 
        35                  40                  45              


Ser Asp Arg Val Val Ala Ser Asn Val Lys Val Glu Thr Gln Ser Asp 
    50                  55                  60                  


Glu Glu Asn Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu 
65                  70                  75                  80  


Asp Leu Arg Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His 
                85                  90                  95      


Arg Asp Gln Gly Ser Ser Ala Leu Ser Gly Val Gly Gly Ile Arg Leu 
            100                 105                 110         


Pro Asn Gly Lys Leu Lys Cys Asp Ile Cys Gly Ile Ile Cys Ile Gly 
        115                 120                 125             


Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro 
    130                 135                 140                 


Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
145                 150                 155                 160 


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
                165                 170                 175     


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
            180                 185                 190         


Arg Thr His Ser Val Gly Lys Pro His Lys Cys Gly Tyr Cys Gly Arg 
        195                 200                 205             


Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys His 
    210                 215                 220                 


Asn Tyr Leu Glu Ser Met Gly Leu Pro Gly Thr Leu Tyr Pro Val Ile 
225                 230                 235                 240 


Lys Glu Glu Thr Asn His Ser Glu Met Ala Glu Asp Leu Cys Lys Ile 
                245                 250                 255     


Gly Ser Glu Arg Ser Leu Val Leu Asp Arg Leu Ala Ser Asn Val Ala 
            260                 265                 270         


Lys Arg Lys Ser Ser Met Pro Gln Lys Phe Leu Gly Asp Lys Gly Leu 
        275                 280                 285             


Ser Asp Thr Pro Tyr Asp Ser Ser Ala Ser Tyr Glu Lys Glu Asn Glu 
    290                 295                 300                 


Met Met Lys Ser His Val Met Asp Gln Ala Ile Asn Asn Ala Ile Asn 
305                 310                 315                 320 


Tyr Leu Gly Ala Glu Ser Leu Arg Pro Leu Val Gln Thr Pro Pro Gly 
                325                 330                 335     


Gly Ser Glu Val Val Pro Val Ile Ser Pro Met Tyr Gln Leu His Lys 
            340                 345                 350         


Pro Leu Ala Glu Gly Thr Pro Arg Ser Asn His Ser Ala Gln Asp Ser 
        355                 360                 365             


Ala Val Glu Asn Leu Leu Leu Leu Ser Lys Ala Lys Leu Val Pro Ser 
    370                 375                 380                 


Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Gln Asp Ser Thr Asp Thr 
385                 390                 395                 400 


Glu Ser Asn Asn Glu Glu Gln Arg Ser Gly Leu Ile Tyr Leu Thr Asn 
                405                 410                 415     


His Ile Ala Pro His Ala Arg Asn Gly Leu Ser Leu Lys Glu Glu His 
            420                 425                 430         


Arg Ala Tyr Asp Leu Leu Arg Ala Ala Ser Glu Asn Ser Gln Asp Ala 
        435                 440                 445             


Leu Arg Val Val Ser Thr Ser Gly Glu Gln Met Lys Val Tyr Lys Cys 
    450                 455                 460                 


Glu His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His 
465                 470                 475                 480 


Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly 
                485                 490                 495     


Tyr His Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Thr Arg Gly 
            500                 505                 510         


Glu His Arg Phe His Met Ser 
        515                 


<210> 12
<211> 3572
<212> DNA
<213> Homo sapiens

<400> 12
ggcagcagag gaaccttttg gaggaggaag aggacacaga ggccctgtag ccaggcacca       60

agatccctcc caggtggctg ggtctgaggg gaactccgag cagccctagg tcctcaaagt      120

ctggatttgt gtggaaaagg cagctctcac ttggccttgg cgaggcctcg gttggttgat      180

aacctgagga ccatggatgc tgatgagggt caagacatgt cccaagtttc agggaaggaa      240

agcccccctg taagcgatac tccagatgag ggcgatgagc ccatgccgat ccccgaggac      300

ctctccacca cctcgggagg acagcaaagc tccaagagtg acagagtcgt ggccagtaat      360

gttaaagtag agactcagag tgatgaagag aatgggcgtg cctgtgaaat gaatggggaa      420

gaatgtgcgg aggatttacg aatgcttgat gcctcgggag agaaaatgaa tggctcccac      480

agggaccaag gcagctcggc tttgtcggga gttggaggca ttcgacttcc taacggaaaa      540

ctaaagtgtg atatctgtgg gatcatttgc atcgggccca atgtgctcat ggttcacaaa      600

agaagccaca ctggagaacg gcccttccag tgcaatcagt gcggggcctc attcacccag      660

aagggcaacc tgctccggca catcaagctg cattccgggg agaagccctt caaatgccac      720

ctctgcaact acgcctgccg ccggagggac gccctcactg gccacctgag gacgcactcc      780

gtcattaaag aagaaactaa tcacagtgaa atggcagaag acctgtgcaa gataggatca      840

gagagatctc tcgtgctgga cagactagca agtaacgtcg ccaaacgtaa gagctctatg      900

cctcagaaat ttcttgggga caagggcctg tccgacacgc cctacgacag cagcgccagc      960

tacgagaagg agaacgaaat gatgaagtcc cacgtgatgg accaagccat caacaacgcc     1020

atcaactacc tgggggccga gtccctgcgc ccgctggtgc agacgccccc gggcggttcc     1080

gaggtggtcc cggtcatcag cccgatgtac cagctgcaca agccgctcgc ggagggcacc     1140

ccgcgctcca accactcggc ccaggacagc gccgtggaga acctgctgct gctctccaag     1200

gccaagttgg tgccctcgga gcgcgaggcg tccccgagca acagctgcca agactccacg     1260

gacaccgaga gcaacaacga ggagcagcgc agcggtctca tctacctgac caaccacatc     1320

gccccgcacg cgcgcaacgg gctgtcgctc aaggaggagc accgcgccta cgacctgctg     1380

cgcgccgcct ccgagaactc gcaggacgcg ctccgcgtgg tcagcaccag cggggagcag     1440

atgaaggtgt acaagtgcga acactgccgg gtgctcttcc tggatcacgt catgtacacc     1500

atccacatgg gctgccacgg cttccgtgat ccttttgagt gcaacatgtg cggctaccac     1560

agccaggacc ggtacgagtt ctcgtcgcac ataacgcgag gggagcaccg cttccacatg     1620

agctaaagcc ctcccgcgcc cccaccccag accccgagcc accccaggaa aagcacaagg     1680

actgccgcct tctcgctccc gccagcagca tagactggac tggaccagac aatgttgtgt     1740

ttggatttgt aactgttttt tgttttttgt ttgagttggt tgattggggt ttgatttgct     1800

tttgaaaaga tttttatttt tagaggcagg gctgcattgg gagcatccag aactgctacc     1860

ttcctagatg tttccccaga ccgctggctg agattccctc acctgtcgct tcctagaatc     1920

cccttctcca aacgattagt ctaaattttc agagagaaat agataaaaca cgccacagcc     1980

tgggaaggag cgtgctctac cctgtgctaa gcacggggtt cgcgcaccag gtgtcttttt     2040

ccagtcccca gaagcagaga gcacagcccc tgctgtgtgg gtctgcaggt gagcagacag     2100

gacaggtgtg ccgccaccca agtgccaaga cacagcaggg ccaacaacct gtgcccaggc     2160

cagcttcgag ctacatgcat ctagggcgga gaggctgcac ttgtgagaga aaatactatt     2220

tcaagtcata ttctgcgtag gaaaatgaat tggttgggga aagtcgtgtc tgtcagactg     2280

ccctgggtgg agggagacgc cgggctagag cctttgggat cgtcctggat tcactggctt     2340

tgcggaggct gctcagatgg cctgagcctc ccgaggcttg ctgccccgta ggaggagact     2400

gtcttcccgt gggcatatct ggggagccct gttccccgct ttttcactcc cataccttta     2460

atggccccca aaatctgtca ctacaattta aacaccagtc ccgaaatttg gatcttcttt     2520

ctttttgaat ctctcaaacg gcaacattcc tcagaaacca aagctttatt tcaaatctct     2580

tccttccctg gctggttcca tctagtacca gaggcctctt ttcctgaaga aatccaatcc     2640

tagccctcat tttaattatg tacatctgtt tgtagccaca agcctgaatt tctcagtgtt     2700

ggtaagtttc tttacctacc ctcactatat attattctcg ttttaaaacc cataaaggag     2760

tgatttagaa cagtcattaa ttttcaactc aatgaaatat gtgaagccca gcatctctgt     2820

tgctaacaca cagagctcac ctgtttgaaa ccaagctttc aaacatgttg aagctcttta     2880

ctgtaaaggc aagccagcat gtgtgtccac acatacatag gatggctggc tctgcacctg     2940

taggatattg gaatgcacag ggcaattgag ggactgagcc agaccttcgg agagtaatgc     3000

caccagatcc cctaggaaag aggaggcaaa tggcactgca ggtgagaacc ccgcccatcc     3060

gtgctatgac atggaggcac tgaagcccga ggaaggtgtg tggagattct aatcccaaca     3120

agcaagggtc tccttcaaga ttaatgctat caatcattaa ggtcattact ctcaaccacc     3180

taggcaatga agaatatacc atttcaaata tttacagtac ttgtcttcac caacactgtc     3240

ccaaggtgaa atgaagcaac agagaggaaa ttgtacataa gtacctcagc atttaatcca     3300

aacaggggtt cttagtctca gcactatgac attttgggct gactacttat ttgttaggca     3360

ggagctctcc tgtgcattgt aggataatta gcagtatccc tggtggctac ccaatagacg     3420

ccagtagcac cccgaattga caacccaaac tctccagaca tcaccaactg tcccctgcga     3480

ggagaaatca ctcctggggg agaaccactg acccaaatga attctaaacc aatcaaatgt     3540

ctgggaagcc ctccaagaaa aaaaaaaaaa aa                                   3572


<210> 13
<211> 509
<212> PRT
<213> Homo sapiens

<400> 13
Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln 
1               5                   10                  15      


Ser Val Pro Ala Glu Ser Ala Ala Val Leu Asn Asp Tyr Ser Leu Thr 
            20                  25                  30          


Lys Ser His Glu Met Glu Asn Val Asp Ser Gly Glu Gly Pro Ala Asn 
        35                  40                  45              


Glu Asp Glu Asp Ile Gly Asp Asp Ser Met Lys Val Lys Asp Glu Tyr 
    50                  55                  60                  


Ser Glu Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala 
65                  70                  75                  80  


Glu Glu Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr 
                85                  90                  95      


Glu Asn Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg 
            100                 105                 110         


Pro Thr Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile 
        115                 120                 125             


Ser Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg 
    130                 135                 140                 


Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys 
                165                 170                 175     


His Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His 
            180                 185                 190         


Leu Arg Thr His Ser Val Glu Lys Pro Tyr Lys Cys Glu Phe Cys Gly 
        195                 200                 205             


Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys 
    210                 215                 220                 


Arg Thr Phe Leu Gln Ser Thr Asp Pro Gly Asp Thr Ala Ser Ala Glu 
225                 230                 235                 240 


Ala Arg His Ile Lys Ala Glu Met Gly Ser Glu Arg Ala Leu Val Leu 
                245                 250                 255     


Asp Arg Leu Ala Ser Asn Val Ala Lys Arg Lys Ser Ser Met Pro Gln 
            260                 265                 270         


Lys Phe Ile Gly Glu Lys Arg His Cys Phe Asp Val Asn Tyr Asn Ser 
        275                 280                 285             


Ser Tyr Met Tyr Glu Lys Glu Ser Glu Leu Ile Gln Thr Arg Met Met 
    290                 295                 300                 


Asp Gln Ala Ile Asn Asn Ala Ile Ser Tyr Leu Gly Ala Glu Ala Leu 
305                 310                 315                 320 


Arg Pro Leu Val Gln Thr Pro Pro Ala Pro Thr Ser Glu Met Val Pro 
                325                 330                 335     


Val Ile Ser Ser Met Tyr Pro Ile Ala Leu Thr Arg Ala Glu Met Ser 
            340                 345                 350         


Asn Gly Ala Pro Gln Glu Leu Glu Lys Lys Ser Ile His Leu Pro Glu 
        355                 360                 365             


Lys Ser Val Pro Ser Glu Arg Gly Leu Ser Pro Asn Asn Ser Gly His 
    370                 375                 380                 


Asp Ser Thr Asp Thr Asp Ser Asn His Glu Glu Arg Gln Asn His Ile 
385                 390                 395                 400 


Tyr Gln Gln Asn His Met Val Leu Ser Arg Ala Arg Asn Gly Met Pro 
                405                 410                 415     


Leu Leu Lys Glu Val Pro Arg Ser Tyr Glu Leu Leu Lys Pro Pro Pro 
            420                 425                 430         


Ile Cys Pro Arg Asp Ser Val Lys Val Ile Asn Lys Glu Gly Glu Val 
        435                 440                 445             


Met Asp Val Tyr Arg Cys Asp His Cys Arg Val Leu Phe Leu Asp Tyr 
    450                 455                 460                 


Val Met Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe 
465                 470                 475                 480 


Glu Cys Asn Met Cys Gly Tyr Arg Ser His Asp Arg Tyr Glu Phe Ser 
                485                 490                 495     


Ser His Ile Ala Arg Gly Glu His Arg Ala Leu Leu Lys 
            500                 505                 


<210> 14
<211> 9686
<212> DNA
<213> Homo sapiens

<400> 14
gcaggagcac gtggagaggc cgagtagcca cagcggcagc tccagcccgg cccggcagcg       60

acatggaaga tatacaaaca aatgcggaac tgaaaagcac tcaggagcag tctgtgcccg      120

cagaaagtgc agcggttttg aatgactaca gtttaaccaa atctcatgaa atggaaaatg      180

tggacagtgg agaaggccca gccaatgaag atgaagacat aggagatgat tcaatgaaag      240

tgaaagatga atacagtgaa agagatgaga atgttttaaa gtcagaaccc atgggaaatg      300

cagaagagcc tgaaatccct tacagctatt caagagaata taatgaatat gaaaacatta      360

agttggagag acatgttgtc tcattcgata gtagcaggcc aaccagtgga aagatgaact      420

gcgatgtgtg tggattatcc tgcatcagct tcaatgtctt aatggttcat aagcgaagcc      480

atactggtga acgcccattc cagtgtaatc agtgtggggc atcttttact cagaaaggta      540

acctcctccg ccacattaaa ctgcacacag gggaaaaacc ttttaagtgt cacctctgca      600

actatgcatg ccaaagaaga gatgcgctca cggggcatct taggacacat tctgtggaga      660

aaccctacaa atgtgagttt tgtggaagga gttacaagca gagaagttcc cttgaggagc      720

acaaggagcg ctgccgtaca tttcttcaga gcactgaccc aggggacact gcaagtgcgg      780

aggcaagaca catcaaagca gagatgggaa gtgaaagagc tctcgtactg gacagattag      840

caagcaatgt ggcaaaacga aaaagctcaa tgcctcagaa attcattggt gagaagcgcc      900

actgctttga tgtcaactat aattcaagtt acatgtatga gaaagagagt gagctcatac      960

agacccgcat gatggaccaa gccatcaata acgccatcag ctatcttggc gccgaagccc     1020

tgcgcccctt ggtccagaca ccgcctgctc ccacctcgga gatggttcca gttatcagca     1080

gcatgtatcc catagccctc acccgggctg agatgtcaaa cggtgcccct caagagctgg     1140

aaaagaaaag catccacctt ccagagaaga gcgtgccttc tgagagaggc ctctctccca     1200

acaatagtgg ccacgactcc acggacactg acagcaacca tgaagaacgc cagaatcaca     1260

tctatcagca aaatcacatg gtcctgtctc gggcccgcaa tgggatgcca cttctgaagg     1320

aggttccccg ctcttacgaa ctcctcaagc ccccgcccat ctgcccaaga gactccgtca     1380

aagtgatcaa caaggaaggg gaggtgatgg atgtgtatcg gtgtgaccac tgccgcgtcc     1440

tcttcctgga ctatgtgatg ttcacgattc acatgggctg ccacggcttc cgtgaccctt     1500

tcgagtgtaa catgtgtgga tatcgaagcc atgatcggta tgagttctcg tctcacatag     1560

ccagaggaga acacagagcc ctgctgaagt gaatatctgg tctcagggat tgctcctatg     1620

tattcagcat cgtttctaaa aaccaatgac ctcgcctaac agattgctct caaaacatac     1680

tcagttccaa acttcttttc ataccatttt tagctgtgtt cacaggggta gccagggaaa     1740

cactgtcttc cttcagaaat tattcgcagg tctagcatat tattactttt gtgaaacctt     1800

tgttttccca tcagggactt gaattttatg gaatttaaaa gccaaaaagg tatttggtca     1860

ttatcttcta cagcagtgga atgagtggtc ccggagatgt gctatatgaa acattctttc     1920

tgagatatat caaccacacg tggaaaagcc tttcagtcat acatgcaaat ccacaaagag     1980

gaagagctga ccagctgacc ttgctgggaa gcctcaccct tctgcccttc acaggctgaa     2040

gggttaagat ctaatctccc taatctaaat gacagtctaa gagtaagtaa aagaacagcc     2100

ataaaataag tatctgttac gagtaactga agaccccatt ctccaagcat cagatccatt     2160

tcctatcaca acatttttaa aaaatgtcat ctgatggcac ttctgcttct gtcctttacc     2220

ttcccatctc cagtgaaaag ctgagctgct ttgggctaaa ccagttgtct atagaagaaa     2280

atctatgcca gaagaactca tggttttaaa tatagaccat catcgaaact ccagaaattt     2340

atccactgtg gatgatgaca tcgctttcct ttggtcaagg ttggcagagc aagggtataa     2400

agggggaaat tgtttggcag caccaacaga aaacaaacaa acaaaaaaca gctacctaaa     2460

acttcttgaa agagttcatg gagaattggt gatacagacc caaagcaaat ttgccaatga     2520

tattttccac aaaaaaagtc caaaaagtat ggctcagcct ccccctcccc acaggagagg     2580

aattggagat agatggcatg tgtgtttaga tcggagttga gctccggaat ggggtgagga     2640

gggacacctc tattgagagg ttctccttga tcaggcaggc ttcggccctt tttttcccat     2700

ttaaatggaa ctgctgtatt ccatgaaaat tcctgaaagt ctgatcacgg ttctgcagat     2760

gtataagtca tccttgtcac tcataatatg tacatactat caggaggagt gctgttatca     2820

tggtaaaatt agcactggaa taggaggtca caaaatgctg gctaattagc tatgtgactt     2880

tgagaaatcg tttaactttt tttttttttt tttttttgag acaggatctc actctgttgc     2940

ccaggctgga gtgcagtggt gcaatcatgg ctcagtgcag cctcgacctc cccaggctca     3000

ggtgatcctc ccacctcagc ctcttgagta ctgggacaac aagtgcacac caccatgtct     3060

ggctacattt tgttcttttt gtagagatag gggtctcact atgttgccca tgctggtctt     3120

gaactcctgg gctcaagcaa tcagcccgcc tcagcctcct aaagtgctgg gattacaggt     3180

gtgagccacc acacccagcc ttatttaact cttaaaactc agtttccggc caggctcggt     3240

ggctcacacc tgtaatccca acactttggg aagccgaggc aggcgcatca tttgaggtca     3300

ggagttcgag accagcctga cccacatggt gaaaccctgt ctctactaaa aatacaaaaa     3360

ttagctgggc agtagtggca catgcctgta atcccagcta ctccggaggc tgaggcagaa     3420

aaatcgctta agcctgggag gttgaggttg cggtgagtgg agatcacact actgcactcc     3480

agtctgggcg acagagtgag accctgtctc aaacaaaaca aaacaaaaac aaacaaacaa     3540

aaacaaaaaa aactcagttt cctcatccat aaaataggaa ttagatttca atgttctctt     3600

aggtcccttc tagctttaat tcatatgtga ttatgcagta accacaaggt attttttaaa     3660

cctcctaatg tatggatatt aagcagaaga gtatttatat gaatacatgt ttcacattcc     3720

tttggtatga aaatggtgtg ttaagttttt cctttaacca ctgagttgtg aatgtgaaga     3780

aggtggtgga gaggaacaaa aaacagaaag gtattttgat cttgccacaa agcatacaca     3840

caaattggca catgcagctg tttgccaaag ccttcttttt ttttttactt tttaagaaat     3900

tatgttaggg aaaataaatt ctgcttccag ggacaacttc atggagccta tttacaaatt     3960

aagagtcagc ttaatttgta acatttctac cagagccaag aatcccaaat tcctggtaga     4020

ttagtgtttt atttctaagg ggcttatgca ttcggctcca actcaactcg tctatgtgct     4080

gccagtaatt aaaatgttcc acctcagact gcacaaatgg cttatccttc tttgtggcat     4140

ggcgtctgtc tcaggaaaaa aggttttatg aaattccatg gcaacagtcc caacatgttt     4200

gagacttcag ctaaaggaat ggatgtattt tggtgtgtag tcttcagtat atcactgtat     4260

ttccgtaata ctagactcca agctatgcca gattgcttat tccctttgtg aaagaggagt     4320

tgctcattac gttcttgaaa tatcgcacat cctgttggtt cttcaaggga caagagaaag     4380

agaatttgga agcagggatt agtagaagag aaaacgaggg aaaggaagcc tttccaccag     4440

attagtgttc aagtctttgc agaggagacc aacttttttt gttttctttt gttttgagac     4500

agtctctcgc tctgttgccc aggctggagt gcagtggcgc gatctcggct cacggcaacc     4560

tccgcctccc gggttcaagc aattctcctg cctcagcctc ccaagtagct gggattacag     4620

gtgctcacca ccaagcccgg ctaatttttg tatttttagt agagacaagg tttcaccatg     4680

ttggccaggc cagtctcaaa ctcctgacct caggtgatct gcccgccttg gcctcccaca     4740

gtgctgggat tacaggcatg agctaccgca cccagcctga gaccaccttt tgcatctcaa     4800

gattgtgaaa ccaaggccca ttccaccagc ctggggactc tttttataga tatgatcctc     4860

ctttttcctg tgactaatga atttgctgca tgatttctat tcttctgagg ttagttttct     4920

gagtaaggtg accactcaca aaggcacttt ctttgtggca ttctgagcct agattggggc     4980

ccatcaattc cagaaaaaat ttatgtgtgg aaactctgca tccttaagtc ttgaagttga     5040

accagatatg cagtggttac catcacacag ataaacgctg ccttctgtac atacccctta     5100

tgctgtacta attaacaaac cccttgccag ggctggggag gtgagggtga aggagaatct     5160

tagcagaagg gcagagtcag gacttgcatc tgccactgct gggcactgaa gccctggagc     5220

agcttcagat agtacctgta ctttctcatg cagactccct ctgaacaaga gccttgtagg     5280

cccctctcct tcatttccca ccagcctctt atcaggcggg ctttccacca tacacccagg     5340

aggccacggt ctgaggaaca accaaaccca tgcaaagggc cgggcgcgat agctcacgcc     5400

tgtaatgcca gcactttggg aggctggggc aggcagatca cctgaggttg ggagttcgag     5460

acctgcctga ccaacatgga gaaaccccca tctctactaa aaatacaaaa ttagccgggc     5520

gtgatggcac atgcctgtaa tcccagctac tcaggaggct gaggcaggag aatcgcttga     5580

acccgggagg cggaggttgc ggtgagccga gatggcacca ctgcactcca gcctcggcaa     5640

caagagcgaa actctgtcta aaacaaaaac aaacaaacaa acaaaaaaac ccaggcaaag     5700

tttccttgca gccaaggtga cagaactggg ctgagggtgg aaaagaaaca gaaccagtgc     5760

tccaggtgtt ttttaatttt ttaatttatt tttatttttt ttgtatatgt atatatatgt     5820

atgtatattt tagaggacca gggtctcact atgttgccta ggccagactc aaactcctgt     5880

gctcaagcaa tcctgcctca gcctcccaag tagctgggat tacaggcatg cacaaacaat     5940

gcccagctct ccaaatgttt tctgtcacta cctgaagtgt tgcatcggta cttcctacgg     6000

aaagaaaact aaatagaagt gtctctcccg tgagccccca ccactaccac cagaaaaaaa     6060

aaagagagaa aatgaactca tcagtcttta gtttcctcaa gttattctcc caaaaagaca     6120

ttcgccttgg cacagataag ccagctaatc ttatgcttta tgacccactg tgagctgttc     6180

ctgacacagc ttctgacttt gtcagtgaca aaatttctca ccttttaaat gcagtgctta     6240

acattttgtt aggcccatac tcaaaatcgg ccagatataa aatgacctca gattttgatc     6300

tcctaggctc aaacaatcct cctacctcag cctcccaagt agctgggact ataggcacac     6360

caccatgcac agctaatttt ttttgtattt ttctgcagag atggcgtttc gccatactgc     6420

ccaggctagt ctcaaaatcc tgggctcaag caatctgccc acctcagcct cccaaagtgc     6480

tggaactaca ggcaagagcc actgcgccca gccacaacct cagatttctt tggcaaacag     6540

aaatgtttaa aaacacaaaa ttttgctcag gtgaaacact gtgttactat caaatctcac     6600

atccacataa agtttttctt ttcggctttg tttcgtgagg aacagacaga acaaagtttt     6660

tccaggtagc atctgtatca ctattattct cctatttcct gtaccacccc cacctcccca     6720

agccctactg aatgtgaggt ttagaatgtt ttaaggaggg tcaggtgcgg tggctcacgc     6780

ctgtaatccc agcactttgg gaggccaagg cgggcggatc acctgagttt gggagttcga     6840

gaccagcctg accaacatgg agaaaccctg tctctactaa aaatacaaaa ttagccaggc     6900

gtggtggcac atgcctgtaa tcccagctac ttaggaggct gaggcaggag aatcgcttga     6960

acccaggagg aggaggttgt ggtgagccga gatcgtgcca ttgcactcca gcctgggtga     7020

cagagtgaga ctccatctcg aaaaaaaaaa tacaaaaatt agctgggtgt ggtggtgcac     7080

acctgtaatc ccagctactc gggaggctga cgcaggagaa ttgcttgaac ctgggaggtg     7140

gaggttgcag tgagccgaga tcgcgccatt gcaatccagc ctggacaaca gagtgagact     7200

ccatctcaaa aaaaaaaaaa aaaagaatgt tttaaggaaa aaaatagtac tgttacatat     7260

aatcccaggt gataagacca caatggaaat gtttaagtcc tcactttaaa gagtacccca     7320

ctgagaagag gtatgttgga ctctagcaga gatttggaaa ctctgggaca ctcaagatgt     7380

gaaagagcct ggctatctga ggactcaaag agtcagcatc gggacttgtg agctcaagaa     7440

gagaaaaggg agtggtgaaa ctttgtccta aaagttagca ccaggaacag aagaaaaaaa     7500

cccgatatat agtgatacct catcttttag agaatgggaa gctatttttg tgttcacaca     7560

gaaagtatag ttcaaaaaac ctctatatcc agagttcaga caaggagaat gatttgagat     7620

ataagtgccg atgaaggagg tcaattttga tctgaaacca gcagctggac ctgggccacc     7680

tcaggaaaag gactctgttc tccaaggcag cacgactgaa tggttctgag aataagccag     7740

ggttcaggac tcctgaccct ttaggaccat ggactcagaa gagcctgaag gacaattgtg     7800

ggctttaaac ttctgagagc ttgtaaagta acacaagact gtgcctctcc cttgccccag     7860

ctgtagatag tctttgcccc accattgtta tgaagataca cagggttttg cagtttgaat     7920

aaattggata caagtttcct cttttttttt ttctttttga gacaaagtct cgctctgttt     7980

ccccaggctg agtgcagtgg cacaatcaag gcttacttgc cgcctcaacc tcctgggctc     8040

aagcaacgag ccatcctccc gtcttagcct cccaactagc tgagactaca ggcgtgggtc     8100

accacaccca gctaattttt gtactttttg tagagacagg gtctcaccat gttgcccagg     8160

ctggtcctga actcctgggc tcaagtaatc tgcccacctc agcctcccaa agtgttgggg     8220

ttacaggcgt gaggcaccgc ggctggcctg agtttcttct taatactgta tcacaattgt     8280

gggctgtctt atgtgttgat atcgattgag ctatttgaaa taggaatgtt aatgggtgta     8340

ttaaattttt gtaaggatat aacaatatct accttccaag gatgttgtga ggttttccat     8400

gattttgtat atgagctaat gttacctttg aggggtggtg tgcattatgt tggatgattg     8460

taaattttca gtggaaaatg taccgtgtcc taaatttaaa gacatgaaaa atatcccaag     8520

atcatactag atcataatag caattccttt acaaatgaat tatggaggta actgatctct     8580

aacagtttcc ttcatgttgt tttaatgcac aagggcagag gatctgctga cccttggaac     8640

cagcgtgagc taaccacgtg ctatagacac ttcatggtgt cgcacccagg gaagtcaaag     8700

cgctttgctc cctcactgtc tgtgagtcct cagccattag taccccaccc cccgctgctc     8760

caaaacttga gttatttcaa atgtttctca ctgttcatct ctccactgac cccactccag     8820

aaagcctgga gagagtccca agatgccacc caccttcccc aatccctcgc cacagatctg     8880

tgtctatctc acactctgta agtgccgctt tgcttcttcc tctcttgaaa agactgagaa     8940

cacacatttt aacatgttag gaaaatgggg cagcctaaaa aatgactgat cccaccgcca     9000

gtgactcatg tatactccag gctagcagac aaggcccttt ttggtgggcc tgcttctgtg     9060

ggttcacaga aaccaaatta ctgtgggttg caaagaatta gcaggtcatt tacaaagcag     9120

acatcccttc acccagactg tggttttgca tgctcaggtt ctcagtctat gagctttggt     9180

gcaggatcat tttggctact ggaaaaacca tagcttattt taaatttctg gttgccaaag     9240

ccaccacacg tgtggtctgt ggatgaccat tgtctgcaga atgacgagga aggaacagaa     9300

tgtggtttgg ggctcagggt ggccttccca ctgggaggga aggcgggagg gagcccttgc     9360

cctgggtttt gacacagcct gtgctcacag cctctcctct catctgcatt tctcagaaat     9420

gccctccctg cccagtggtg actttccctc gtcactccta tggagttcta cctggagccc     9480

agccatgtgt ggaactgtga agtttactcc tctgtaaaga tggtttaaag aaagtcagct     9540

tctgaaatgt aacaatgcta acccttgctg gaaccctgta agaaatagcc ctgctgatag     9600

ttttctaggt ttatcatgtt tgatttttac actgaaaaat aaaaaaatcc tggtatgttt     9660

gaaattaaaa aaaaaaaaaa aaaaaa                                          9686


<210> 15
<211> 237
<212> PRT
<213> Homo sapiens

<400> 15
Met Ala Met Phe Arg Ser Leu Val Ala Ser Ala Gln Gln Arg Gln Pro 
1               5                   10                  15      


Pro Ala Gly Pro Ala Gly Gly Asp Ser Gly Leu Glu Ala Gln Tyr Thr 
            20                  25                  30          


Cys Pro Ile Cys Leu Glu Val Tyr His Arg Pro Val Ala Ile Gly Ser 
        35                  40                  45              


Cys Gly His Thr Phe Cys Gly Glu Cys Leu Gln Pro Cys Leu Gln Val 
    50                  55                  60                  


Pro Ser Pro Leu Cys Pro Leu Cys Arg Leu Pro Phe Asp Pro Lys Lys 
65                  70                  75                  80  


Val Asp Lys Ala Thr His Val Glu Lys Gln Leu Ser Ser Tyr Lys Ala 
                85                  90                  95      


Pro Cys Arg Gly Cys Asn Lys Lys Val Thr Leu Ala Lys Met Arg Val 
            100                 105                 110         


His Ile Ser Ser Cys Leu Lys Val Gln Glu Gln Met Ala Asn Cys Pro 
        115                 120                 125             


Lys Phe Val Pro Val Val Pro Thr Ser Gln Pro Ile Pro Ser Asn Ile 
    130                 135                 140                 


Pro Asn Arg Ser Thr Phe Ala Cys Pro Tyr Cys Gly Ala Arg Asn Leu 
145                 150                 155                 160 


Asp Gln Gln Glu Leu Val Lys His Cys Val Glu Ser His Arg Ser Asp 
                165                 170                 175     


Pro Asn Arg Val Val Cys Pro Ile Cys Ser Ala Met Pro Trp Gly Asp 
            180                 185                 190         


Pro Ser Tyr Lys Ser Ala Asn Phe Leu Gln His Leu Leu His Arg His 
        195                 200                 205             


Lys Phe Ser Tyr Asp Thr Phe Val Asp Tyr Ser Ile Asp Glu Glu Ala 
    210                 215                 220                 


Ala Phe Gln Ala Ala Leu Ala Leu Ser Leu Ser Glu Asn 
225                 230                 235         


<210> 16
<211> 1888
<212> DNA
<213> Homo sapiens

<400> 16
ctacgatgac gtcagcgcgg cgcagtagcg gctgtgacta gcgggccggc ccgggccagg       60

acagcgggcg gcgggcggcg cgggcctggc cccgggatgg ctatgttccg cagcctggtg      120

gcctcggctc agcagcggca gccgccggcc gggccggcgg gcggcgacag cggcctggag      180

gcgcagtaca cctgccccat ctgcctggag gtctatcacc ggcccgtggc catcggcagc      240

tgcggccaca cgttctgcgg ggagtgtctc cagccctgcc tgcaggtgcc atccccgctg      300

tgcccactct gccgcctgcc cttcgacccc aagaaggtgg acaaggccac ccacgtggag      360

aagcagctct catcctacaa agcgccctgt cgaggctgca acaaaaaggt gaccctggca      420

aagatgagag tgcacatttc gtcctgcctg aaggtccagg agcagatggc caactgcccc      480

aagttcgtcc ccgtggtgcc cacatcacag cctatcccca gcaacatccc caacaggtcc      540

accttcgcct gcccgtactg tggtgcccgc aacctggacc agcaggagct ggtgaagcac      600

tgtgtggaaa gccaccgcag cgaccccaac cgcgtggtgt gccccatctg ctcggcaatg      660

ccctgggggg accccagcta caagagcgcc aacttcctgc agcacctgct tcaccgacac      720

aagttctcct acgacacctt tgtggactac agtattgacg aggaggccgc cttccaggct      780

gctctggccc tgtctctctc tgagaactga agggaagcgc agccacccgc ctgcgtctgg      840

ggtcagggat gtccccgctc ctgtgtcgca cctggcacct gctcgggagc gcacctcacc      900

ggactgagct cacaggagga gcctgcaccc gcgcagaagg ggagccgggg ccgagcctcc      960

gggcctgaat acgggccagc cgccgaggcc gccagagcag ggccgcctgg tcccaccggc     1020

gtcgctgggt tcttcggtgc ttctggccga gcaggcggcc tacttgggca gggctggacg     1080

ctgggacctg gagctgccgc cgtctcttca aagccatgat accccctcgt gggaagaagg     1140

gaccgacgcg cgagtcgcgc tccgcagtcg agccgggagg aacccaggct gctgccctgc     1200

ccagcccgac cctgccccgg ccccgcttcc accttgcgca tttggtactg gcttttgtga     1260

tacttaggaa ccctggcatc ttttctatat tatccagtgt gataatcttt tcacgtttta     1320

tagagcaaag acagagcagt tactcttcat attgcaatat ctgtgtttga ctaggaataa     1380

tagtattttt atggaacatt tacaaaatta tattttttaa gaaaacaatc aaaacaagca     1440

ttgggggatt ggggcaagga tggaaggagc agtggggcag ctgccagagc tcaggcgagc     1500

catggggtct gctgtggggt ctgccctggc cacccactgt gtgtctgggt ccttgaggtt     1560

tgtacgtttc tctttgatga ccaggaagaa atcccagcac cccagccaca ggctgtggct     1620

gctcccagca gaggcggggc cggcagagaa ggggcctcct ccacccagag tcctggcctt     1680

ggcccgctgt caccttcaaa gctgactgtg ccccgctgcg ggaggggacg gcaccccagt     1740

ggtggcagag cttgggggcc tgggcagggg cccgcttggc gggccgggca acacgtcaac     1800

attcttttct gttcttggca ttaattattg ctgtcttttt tttaaaaaaa aaagtttaaa     1860

taaaatgtct cagagcatct ctaaaaaa                                        1888


<210> 17
<211> 570
<212> PRT
<213> Homo sapiens

<400> 17
Met Pro Gly Glu Thr Glu Glu Pro Arg Pro Pro Glu Gln Gln Asp Gln 
1               5                   10                  15      


Glu Gly Gly Glu Ala Ala Lys Ala Ala Pro Glu Glu Pro Gln Gln Arg 
            20                  25                  30          


Pro Pro Glu Ala Val Ala Ala Ala Pro Ala Gly Thr Thr Ser Ser Arg 
        35                  40                  45              


Val Leu Arg Gly Gly Arg Asp Arg Gly Arg Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Val Ser Arg Arg Arg Lys Ala Glu Tyr Pro Arg Arg Arg 
65                  70                  75                  80  


Arg Ser Ser Pro Ser Ala Arg Pro Pro Asp Val Pro Gly Gln Gln Pro 
                85                  90                  95      


Gln Ala Ala Lys Ser Pro Ser Pro Val Gln Gly Lys Lys Ser Pro Arg 
            100                 105                 110         


Leu Leu Cys Ile Glu Lys Val Thr Thr Asp Lys Asp Pro Lys Glu Glu 
        115                 120                 125             


Lys Glu Glu Glu Asp Asp Ser Ala Leu Pro Gln Glu Val Ser Ile Ala 
    130                 135                 140                 


Ala Ser Arg Pro Ser Arg Gly Trp Arg Ser Ser Arg Thr Ser Val Ser 
145                 150                 155                 160 


Arg His Arg Asp Thr Glu Asn Thr Arg Ser Ser Arg Ser Lys Thr Gly 
                165                 170                 175     


Ser Leu Gln Leu Ile Cys Lys Ser Glu Pro Asn Thr Asp Gln Leu Asp 
            180                 185                 190         


Tyr Asp Val Gly Glu Glu His Gln Ser Pro Gly Gly Ile Ser Ser Glu 
        195                 200                 205             


Glu Glu Glu Glu Glu Glu Glu Glu Met Leu Ile Ser Glu Glu Glu Ile 
    210                 215                 220                 


Pro Phe Lys Asp Asp Pro Arg Asp Glu Thr Tyr Lys Pro His Leu Glu 
225                 230                 235                 240 


Arg Glu Thr Pro Lys Pro Arg Arg Lys Ser Gly Lys Val Lys Glu Glu 
                245                 250                 255     


Lys Glu Lys Lys Glu Ile Lys Val Glu Val Glu Val Glu Val Lys Glu 
            260                 265                 270         


Glu Glu Asn Glu Ile Arg Glu Asp Glu Glu Pro Pro Arg Lys Arg Gly 
        275                 280                 285             


Arg Arg Arg Lys Asp Asp Lys Ser Pro Arg Leu Pro Lys Arg Arg Lys 
    290                 295                 300                 


Lys Pro Pro Ile Gln Tyr Val Arg Cys Glu Met Glu Gly Cys Gly Thr 
305                 310                 315                 320 


Val Leu Ala His Pro Arg Tyr Leu Gln His His Ile Lys Tyr Gln His 
                325                 330                 335     


Leu Leu Lys Lys Lys Tyr Val Cys Pro His Pro Ser Cys Gly Arg Leu 
            340                 345                 350         


Phe Arg Leu Gln Lys Gln Leu Leu Arg His Ala Lys His His Thr Asp 
        355                 360                 365             


Gln Arg Asp Tyr Ile Cys Glu Tyr Cys Ala Arg Ala Phe Lys Ser Ser 
    370                 375                 380                 


His Asn Leu Ala Val His Arg Met Ile His Thr Gly Glu Lys Pro Leu 
385                 390                 395                 400 


Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu Asn 
                405                 410                 415     


Trp His Met Lys Lys His Asp Ala Asp Ser Phe Tyr Gln Phe Ser Cys 
            420                 425                 430         


Asn Ile Cys Gly Lys Lys Phe Glu Lys Lys Asp Ser Val Val Ala His 
        435                 440                 445             


Lys Ala Lys Ser His Pro Glu Val Leu Ile Ala Glu Ala Leu Ala Ala 
    450                 455                 460                 


Asn Ala Gly Ala Leu Ile Thr Ser Thr Asp Ile Leu Gly Thr Asn Pro 
465                 470                 475                 480 


Glu Ser Leu Thr Gln Pro Ser Asp Gly Gln Gly Leu Pro Leu Leu Pro 
                485                 490                 495     


Glu Pro Leu Gly Asn Ser Thr Ser Gly Glu Cys Leu Leu Leu Glu Ala 
            500                 505                 510         


Glu Gly Met Ser Lys Ser Tyr Cys Ser Gly Thr Glu Arg Val Ser Leu 
        515                 520                 525             


Met Ala Asp Gly Lys Ile Phe Val Gly Ser Gly Ser Ser Gly Gly Thr 
    530                 535                 540                 


Glu Gly Leu Val Met Asn Ser Asp Ile Leu Gly Ala Thr Thr Glu Val 
545                 550                 555                 560 


Leu Ile Glu Asp Ser Asp Ser Ala Gly Pro 
                565                 570 


<210> 18
<211> 5735
<212> DNA
<213> Homo sapiens

<400> 18
gtgggggggg cgccctcgga gccgggcgga ggggaggggg gaaagaggag cgcagggtga       60

gagtgagccg caggcttcgg gaggcgaggg ggcgggggga gcagcgccga ggccgccgcc      120

tccgcctccg ccgcctagga ctagggggtg ggggacggac aagccccgat gccgggggag      180

acggaagagc cgagaccccc ggagcagcag gaccaggaag ggggagaggc ggccaaggcg      240

gctccggagg agccccaaca acggccccct gaggcggtcg cggcggcgcc tgcagggacc      300

actagcagcc gcgtgctgag gggaggtcgg gaccgaggcc gggccgctgc ggccgccgcc      360

gccgcagctg tgtcccgccg gaggaaggcc gagtatcccc gccggcggag gagcagcccc      420

agcgccaggc ctcccgacgt ccccgggcag cagccccagg ccgcgaagtc cccgtctcca      480

gttcagggca agaagagtcc gcgactccta tgcatagaaa aagtaacaac tgataaagat      540

cccaaggaag aaaaagagga agaagacgat tctgccctcc ctcaggaagt ttccattgct      600

gcatctagac ctagccgggg ctggcgtagt agtaggacat ctgtttctcg ccatcgtgat      660

acagagaaca cccgaagctc tcggtccaag accggttcat tgcagctcat ttgcaagtca      720

gaaccaaata cagaccaact tgattatgat gttggagaag agcatcagtc tccaggtggc      780

attagtagtg aagaggaaga ggaggaggaa gaagagatgt taatcagtga agaggagata      840

ccattcaaag atgatccaag agatgagacc tacaaacccc acttagaaag ggaaacccca      900

aagccacgga gaaaatcagg gaaggtaaaa gaagagaagg agaagaagga aattaaagtg      960

gaagtagagg tggaggtgaa agaagaggag aatgaaatta gagaggatga ggaacctcca     1020

aggaagagag gaagaagacg aaaagatgac aaaagtccac gtttacccaa aaggagaaaa     1080

aagcctccaa tccagtatgt ccgttgtgag atggaaggat gtggaactgt ccttgcccat     1140

cctcgctatt tgcagcacca cattaaatac cagcatttgc tgaagaagaa atatgtatgt     1200

ccccatccct cctgtggacg actcttcagg cttcagaagc aacttctgcg acatgccaaa     1260

catcatacag atcaaaggga ttatatctgt gaatattgtg ctcgggcctt caagagttcc     1320

cacaatctgg cagtgcaccg gatgattcac actggcgaga agccattaca atgtgagatc     1380

tgtggattta cttgtcgaca aaaggcatct cttaattggc acatgaagaa acatgatgca     1440

gactccttct accagttttc ttgcaatatc tgtggcaaaa aatttgagaa gaaggacagc     1500

gtagtggcac acaaggcaaa aagccaccct gaggtgctga ttgcagaagc tctggctgcc     1560

aatgcaggcg ccctcatcac cagcacagat atcttgggca ctaacccaga gtccctgacg     1620

cagccttcag atggtcaggg tcttcctctt cttcctgagc ccttgggaaa ctcaacctct     1680

ggagagtgcc tactgttaga agctgaaggg atgtcaaagt catactgcag tgggacggaa     1740

cgggtgagcc tgatggctga tgggaagatc tttgtgggaa gcggcagcag tggaggcact     1800

gaagggctgg ttatgaactc agatatactc ggtgctacca cagaggttct gattgaagat     1860

tcagactctg ccggacctta gtggacagga agacttgggg catgggacag ctcagacttt     1920

gtatttaaaa gttaaaaagg acaaaaaaaa aatctaaagc atttaaaatc tagtgaaata     1980

actgaagggc ctgctctttc cattgtggat cacagcacac acatacatac accctccacc     2040

tccccatccc ctgttctccc tctgttgctc cccttataaa attgatgttg tctttaccag     2100

aaaggtagac aaaaaagaag cagcagcagc tcttaaagtg agggttattc tcatactcgg     2160

ttccagccat cagcagactt cctgctcatc ggcagatccc cctttccaac ctgtaactct     2220

gatgtgctct ggatcagctt ttaactttta atcatatatt actgtcttct aaatcccttc     2280

tcctcctcta ctgctgccct atggttctgg ctcctacccc ctgcggcaca cttatcttca     2340

aataccatag aattctaatc tctggaggct ggcagcttga cttggcactt tagggcccct     2400

tagcagggtg agctgttaaa acagcacaca tctctcatcc cctcttcctt tattcccccc     2460

tgggtttcag aaaggaagga tatatgggga ccacctcccc cttctttgat cccagcatct     2520

cagtccccct cccaaccctc catatggctc tcaatggtgc tcacttgctt ggaagcaggc     2580

tcccaatagg gagggggctg ccctctacag tctctttgac tgtaagacag ggctctgtat     2640

cagtgagacg atgagaaaag tcccaggcta atggcagaaa tttgcacttt gaacatgtgt     2700

gtttttgtgt tgtggaacct gagattcctt atttattaac aggaagtctg attttttttt     2760

tttggagtct ttgttgctat attttgtggg gctgggagag agagattaga ttattttgac     2820

atgggatccc ttccataaca ggtactttga aggcaagaca tagggttgaa gaagcacagc     2880

cagcctctga aatcatagct ctccagtggc ttttaaagaa agctggtcct cagcactaac     2940

aaaatcacta caatagccta gtgctttttt ggaagccttt ttagggaaga atgttaggtt     3000

catggtaact agtatgctct ttgagatttt tacagtgttg aaacttaaga attttgagag     3060

ggtgaggagg gttgttcaga atctaaatta cagatagatg attgtttctt gtgaatttgt     3120

ttcttttcct ttttttttgt ccctaccatt tccttacatt tcccttgggg cccatctctg     3180

gctccttgct ttttgtttct tgctttgctt tatcagttca ttccagctcc ctgttagtga     3240

aggacactgc tgttagtgaa ggaacaaagt ctatgagtcc taaaatttta agtcaaagaa     3300

aactgctctg tttccccttt agtaacactt ctgaagagga aaaacttcaa tagccaaagt     3360

taataatcct atataataat tgctttggct ttcacctaaa attctgggca tcacaatttc     3420

cttgggatag aggttgtgtt ggggaataga ttgcttattg ctgttcactg gagagaaaag     3480

gtagtgtttt tgtacaaggt cataccgcca gaagccccaa atcctatttt ggctcatctt     3540

caggtaaaga gtaattccta tcctgtgtgc ctcagaagct agaatcgaag gcttacccta     3600

ttcattgttt attgtcagaa atgcatgatg gctcttggaa agaatgacgt tttgctggaa     3660

aaaaaaaaaa gaacagtttg tgtttcacaa acatggctta tcaatttttt caaagaattc     3720

ttttttccca aaaagaggag taacaaaatg tcatttctga aagaggctta ctttatacca     3780

actagtgtca gcatttggga tgccagggaa cagagagtga gacacctaca atcaccagtc     3840

tcaaatgcgc tattgtttct tttcagagtg ttgcagattt gccatttctc cataatatgg     3900

ggatagaaaa tggaataaag atagaaggga tgtagaatat gctttcctgc caacatggtt     3960

tggagtcgac tttggtatat tgactagatt tgaaaataca agattgatta gatgaatcta     4020

caaaaaagtt gtcctcctct caggtccctt ttacactttt tgactaacta gcatctatat     4080

tccacactta gcttttttgt cacacttatc ctttgtctcc gtaaatttca tttgcagtgg     4140

ttagtcatca gatattttag ccacctacac aaaagcaaac tgcattttta aaaatctttc     4200

tgagatggga gaaaatgtat tctcctttcc tataccgctc tcccaacaaa aaaacaacta     4260

gttagttcta ctaattagaa acttgctgta ctttttcttt tcttttaggg gtcaaggacc     4320

ctctttatag ctaccatttg cctacaataa attattgcag cagtttgcaa tactaaaata     4380

ttttttatag actttatatt tttccttttg ataaagggat gctgcatagt agagttggtg     4440

taattaaact atctcagccg tttccctgct ttcccttctg ctccatatgc ctcattgtcc     4500

ttccagggag ctcttttaat cttaaagttc tacatttcat gctcttagtc aaattctgtt     4560

acctttttaa taactcttcc cactgcatat ttccatcttg aattggtggt tctaaattct     4620

gaaactgtag ttgagataca gctatttaat atttctggga gatgtgcatc cctcttcttt     4680

gtggttgccc aaggttgttt tgcgtaactg agactccttg atatgcttca gagaatttag     4740

gcaaacactg gccatggccg tgggagtact gggagtaaaa taaaaatatc gaggtataga     4800

ctagcatcca catagagcac ttgaacctcc tttgtacctg tttggggaaa aagtataatg     4860

agtgtactac caatctaact aagattatta tagtctggtt gtttgaaata ccattttttt     4920

ctccttttgt gtttttccca ctttccaatg tactcaagaa aattgaacaa atgtaatgga     4980

tcaatttaaa atattttatt tcttaaaagc cttttttgcc tgttgtaatg tgcaggaccc     5040

ttctcctttc atgggagaga caggtagtta cctgaatata ggttgaaaag gttatgtaaa     5100

aagaaattat aataaaaggg atactttgct tttcaaatct ttgttttctc ttattctagg     5160

taaggcatat taaaaataaa tatgtaaaga agaaaaataa aagttgtctt catggaagca     5220

acttgtcttc cttggttgta ctgagttaca gttatcctag gggtgaaaca tgtgatgctg     5280

ctaagcaaac caaatgccct cagaacaggt gttatgtggg gcatactatt gtttgctttt     5340

gttgagaatc aggtggttaa tttttgactg ttcttgattt ctaatgctga aatgacatga     5400

ttctgttatt cagcaaactt ggaaatcttg atgttttgac aactgcctcc taggaaaact     5460

ggccatatgt taattaacct agtagatgga aaattaagga ttatgtgagg ttaattttac     5520

cctgataatg acaaaacctt gatagcattt aatattaata cttcttctca aaattgaatg     5580

tttatatcaa gtactgattt ttattttaaa aaagaaaaaa ctataatcct tctgccttcc     5640

aaaagccatg ctgtgatagc tgcccaggct gctctgttac atctcccatt tattgtttac     5700

ttttataaat ttgcttctaa gatggaaaaa aaaaa                                5735


<210> 19
<211> 524
<212> PRT
<213> Homo sapiens

<400> 19
Met Pro Leu Val His Met Ala Ser Ser Pro Ala Val Asp Val Ser Cys 
1               5                   10                  15      


Arg Arg Arg Glu Lys Arg Arg Gln Leu Asp Ala Arg Arg Ser Lys Cys 
            20                  25                  30          


Arg Ile Arg Leu Gly Gly His Met Glu Gln Trp Cys Leu Leu Lys Glu 
        35                  40                  45              


Arg Leu Gly Phe Ser Leu His Ser Gln Leu Ala Lys Phe Leu Leu Asp 
    50                  55                  60                  


Arg Tyr Thr Ser Ser Gly Cys Val Leu Cys Ala Gly Pro Glu Pro Leu 
65                  70                  75                  80  


Pro Pro Lys Gly Leu Gln Tyr Leu Val Leu Leu Ser His Ala His Ser 
                85                  90                  95      


Arg Glu Cys Ser Leu Val Pro Gly Leu Arg Gly Pro Gly Gly Gln Asp 
            100                 105                 110         


Gly Gly Leu Val Trp Glu Cys Ser Ala Gly His Thr Phe Ser Trp Gly 
        115                 120                 125             


Pro Ser Leu Ser Pro Thr Pro Ser Glu Ala Pro Lys Pro Ala Ser Leu 
    130                 135                 140                 


Pro His Thr Thr Arg Arg Ser Trp Cys Ser Glu Ala Thr Ser Gly Gln 
145                 150                 155                 160 


Glu Leu Ala Asp Leu Glu Ser Glu His Asp Glu Arg Thr Gln Glu Ala 
                165                 170                 175     


Arg Leu Pro Arg Arg Val Gly Pro Pro Pro Glu Thr Phe Pro Pro Pro 
            180                 185                 190         


Gly Glu Glu Glu Gly Glu Glu Glu Glu Asp Asn Asp Glu Asp Glu Glu 
        195                 200                 205             


Glu Met Leu Ser Asp Ala Ser Leu Trp Thr Tyr Ser Ser Ser Pro Asp 
    210                 215                 220                 


Asp Ser Glu Pro Asp Ala Pro Arg Leu Leu Pro Ser Pro Val Thr Cys 
225                 230                 235                 240 


Thr Pro Lys Glu Gly Glu Thr Pro Pro Ala Pro Ala Ala Leu Ser Ser 
                245                 250                 255     


Pro Leu Ala Val Pro Ala Leu Ser Ala Ser Ser Leu Ser Ser Arg Ala 
            260                 265                 270         


Pro Pro Pro Ala Glu Val Arg Val Gln Pro Gln Leu Ser Arg Thr Pro 
        275                 280                 285             


Gln Ala Ala Gln Gln Thr Glu Ala Leu Ala Ser Thr Gly Ser Gln Ala 
    290                 295                 300                 


Gln Ser Ala Pro Thr Pro Ala Trp Asp Glu Asp Thr Ala Gln Ile Gly 
305                 310                 315                 320 


Pro Lys Arg Ile Arg Lys Ala Ala Lys Arg Glu Leu Met Pro Cys Asp 
                325                 330                 335     


Phe Pro Gly Cys Gly Arg Ile Phe Ser Asn Arg Gln Tyr Leu Asn His 
            340                 345                 350         


His Lys Lys Tyr Gln His Ile His Gln Lys Ser Phe Ser Cys Pro Glu 
        355                 360                 365             


Pro Ala Cys Gly Lys Ser Phe Asn Phe Lys Lys His Leu Lys Glu His 
    370                 375                 380                 


Met Lys Leu His Ser Asp Thr Arg Asp Tyr Ile Cys Glu Phe Cys Ala 
385                 390                 395                 400 


Arg Ser Phe Arg Thr Ser Ser Asn Leu Val Ile His Arg Arg Ile His 
                405                 410                 415     


Thr Gly Glu Lys Pro Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg 
            420                 425                 430         


Gln Lys Ala Ser Leu Asn Trp His Gln Arg Lys His Ala Glu Thr Val 
        435                 440                 445             


Ala Ala Leu Arg Phe Pro Cys Glu Phe Cys Gly Lys Arg Phe Glu Lys 
    450                 455                 460                 


Pro Asp Ser Val Ala Ala His Arg Ser Lys Ser His Pro Ala Leu Leu 
465                 470                 475                 480 


Leu Ala Pro Gln Glu Ser Pro Ser Gly Pro Leu Glu Pro Cys Pro Ser 
                485                 490                 495     


Ile Ser Ala Pro Gly Pro Leu Gly Ser Ser Glu Gly Ser Arg Pro Ser 
            500                 505                 510         


Ala Ser Pro Gln Ala Pro Thr Leu Leu Pro Gln Gln 
        515                 520                 


<210> 20
<211> 2208
<212> DNA
<213> Homo sapiens

<400> 20
ggcgcacagg taaggccggg gtgggggtgg gtcgcgacgg gggctctggg cagcctggga       60

actgccattg ggattagtcc gctccactca ctgtcagcat taagtggggg tgcccaagac      120

ggggtggatg gggggcgccc tccagacctc tgaccacggc ctcaccgcca ctcgacccaa      180

ctatgaagag cgcccccagc tgcacgccag gacacgacct ttccttcccc tagaaaccag      240

taaaggccgc tgccctattc aagatgaaat gtgtggaccg cccccagccc agttgaaatt      300

tcccgtgaaa gtctctcgcc ccttccccac agctccactt cagtggactg gagggcgcag      360

gcctttgttc tgactgcttc tgtctgcctg cctcccaccc gacgacactc acatgcctct      420

ggtgcacatg gcttcctccc cggcggtgga cgtgtcctgc aggcggcggg agaagcggcg      480

gcagctggac gcgcgccgca gcaagtgccg catccgcctg ggcggccaca tggagcagtg      540

gtgcctcctc aaggagcggc tgggcttctc cctgcactcg cagctcgcca agttcctgtt      600

ggaccggtac acttcttcag gctgtgtcct ctgtgcaggt cctgagcctt tgcctccaaa      660

aggtctgcag tatctggtgc tcttgtctca tgcccacagc cgagagtgca gcctggtgcc      720

cgggcttcgg gggcctggcg gccaagatgg ggggcttgtg tgggagtgct cagcaggcca      780

taccttctcc tggggaccct ctttgagccc tacaccttca gaggcaccca agccagcctc      840

ccttccacat actactcgga gaagttggtg ttccgaggcc acgagtgggc aggagcttgc      900

agatttggaa tctgagcatg atgagaggac tcaagaggcc aggttgccca ggagggtggg      960

acccccacca gagaccttcc cacctccagg agaggaagag ggtgaggaag aagaggacaa     1020

tgatgaggat gaagaggaga tgctcagtga tgccagctta tggacctaca gctcctcccc     1080

agatgatagt gagcctgatg cccccagact actgccttcc cctgtcacct gcacacctaa     1140

agagggggag acaccaccag cccctgcagc actctccagt cctcttgctg tgccggcctt     1200

gtcagcatcc tcattgagtt ccagagctcc tccacctgca gaagtcaggg tgcagccaca     1260

gctcagcagg acccctcaag cggcccagca gactgaggcc ctggccagca ctgggagtca     1320

ggcccagtct gctccaaccc cggcctggga tgaggacact gcacaaattg gccccaagag     1380

aattaggaaa gctgccaaaa gagagctgat gccttgtgac ttccctggct gtggaaggat     1440

cttctccaac cggcagtatt tgaatcacca caaaaagtac cagcacatcc accagaagtc     1500

tttctcctgc ccagagccag cctgtgggaa gtctttcaac tttaagaaac acctgaagga     1560

gcacatgaag ctgcacagtg acacccggga ctacatctgt gagttctgcg cccggtcttt     1620

ccgcactagc agcaaccttg tcatccacag acgtatccac actggagaaa aacccctgca     1680

gtgtgagata tgcgggttta cctgccgcca gaaggcttcc ctgaactggc accagcgcaa     1740

gcatgcagag acggtggctg ccttgcgctt cccctgtgaa ttctgcggca agcgctttga     1800

gaagccagac agtgttgcag cccaccgtag caaaagtcac ccagccctgc ttctagcccc     1860

tcaagagtca cccagtggtc ccctagagcc ctgtcccagc atctctgccc ctgggcctct     1920

gggatccagc gaggggtcca ggccctctgc atctcctcag gctccaaccc tgcttcctca     1980

gcaatgagct ctcctccagc tttggctttg ggaagccaga ctccagggac tgaaaaggag     2040

caacaaggag agggtctgct tgagaaatgc cagatgcttg gtccccagga actaaggcga     2100

cagagtgcag ggtgggggca agactgggct gtaggggagc tggactactt tagtcttcct     2160

aaaggacaaa ataaacagta ttttatgcag gcaaaaaaaa aaaaaaaa                  2208


<210> 21
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Glu Arg Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln 
1               5                   10                  15      


Lys Gly Asn Leu Leu Arg His Ile Lys Leu 
            20                  25      


<210> 22
<211> 60
<212> PRT
<213> Homo sapiens

<400> 22
Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro 
1               5                   10                  15      


Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
            20                  25                  30          


Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys His 
        35                  40                  45              


Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu 
    50                  55                  60  


