                         SEQUENCE LISTING

<110>  LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA 
       MEDICAL CENTER
       Wang, Christina
       Lue, Yanhe
       Swerdloff , Ronald  S.
 
<120>  HUMANIN COMPOSITIONS, METHODS AND USES FOR PROTECTING HEART FROM 
       STRESS AND CHEMOTHERAPY

<130>  022098-0448579

<140>  To Be Assigned
<141>  2016-09-08

<150>  62/215,974
<151>  2015-09-09

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  1

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Leu Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  2
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  2

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Leu Thr Gly Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  3
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  3

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Leu Thr Asp Ser Glu 
1               5                   10                  15      


Ile Asp Leu Pro Val Lys Arg Arg Ala 
            20                  25  


<210>  4
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  4

Met Ala Pro Ala Gly Ala Ser Cys Leu Leu Leu Leu Thr Gly Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  5
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  5

Met Ala Pro Ala Gly Ala Ser Cys Leu Leu Leu Leu Thr Asp Ser Glu 
1               5                   10                  15      


Ile Asp Leu Pro Val Lys Arg Arg Ala 
            20                  25  


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  6

Pro Ala Gly Ala Ser Cys Leu Leu Leu Leu Thr Asp Ser Glu Ile Asp 
1               5                   10                  15      


Leu Pro 
        


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  7

Pro Ala Gly Ala Ser Arg Leu Leu Leu Leu Thr Gly Glu Ile Asp Leu 
1               5                   10                  15      


Pro 
    


<210>  8
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  8

Glu Phe Leu Ile Val Ile Lys Ser Met Ala Pro Arg Gly Phe Ser Cys 
1               5                   10                  15      


Leu Leu Leu Leu Thr Ser Glu Ile Asp Leu Pro Val Lys Arg Arg Ala 
            20                  25                  30          


<210>  9
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  9

Glu Phe Leu Ile Val Ile Lys Ser Met Ala Pro Arg Gly Phe Ser Cys 
1               5                   10                  15      


Leu Leu Leu Leu Thr Gly Glu Ile Asp Leu Pro Val Lys Arg Arg Ala 
            20                  25                  30          


<210>  10
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  10

Glu Phe Leu Ile Val Ile Lys Ser Met Ala Pro Ala Gly Ala Ser Cys 
1               5                   10                  15      


Leu Leu Leu Leu Thr Gly Glu Ile Asp Leu Pro Val Lys Arg Arg Ala 
            20                  25                  30          


<210>  11
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  11

Ser Ala Leu Leu Arg Ser Ile Pro Ala Pro Ala Gly Ala Ser Arg Leu 
1               5                   10                  15      


Leu Leu Leu Thr Gly Glu Ile Asp Leu Pro 
            20                  25      


<210>  12
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  12

Met Ala Pro Arg Gly Phe Ser Cys Arg Leu Leu Leu Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Met Thr Pro Arg Gly Phe Ser Cys Leu Leu Leu Pro Thr Ser Glu Thr 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Xaa 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Ser Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Xaa Xaa 
            20                  


<210>  15
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  15

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Ser Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  16

Met Cys His Trp Ala Gly Gly Ala Ser Asn Thr Gly Asp Ala Arg Gly 
1               5                   10                  15      


Asp Val Phe Gly Lys Gln Ala Gly 
            20                  


<210>  17
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  17

Met Gly Val Lys Phe Phe Thr Leu Ser Thr Arg Phe Phe Pro Ser Val 
1               5                   10                  15      


Gln Arg Ala Val Pro Leu Trp Thr Asn Ser 
            20                  25      


<210>  18
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  18

Met Leu Gly Tyr Asn Phe Ser Ser Phe Pro Cys Gly Thr Ile Ser Ile 
1               5                   10                  15      


Ala Pro Gly Phe Asn Phe Tyr Arg Leu Tyr Phe Ile Trp Val Asn Gly 
            20                  25                  30          


Leu Ala Lys Val Val Trp 
        35              


<210>  19
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  19

Met Leu Glu Val Met Phe Leu Val Asn Arg Arg Gly Lys Ile Cys Arg 
1               5                   10                  15      


Val Pro Phe Thr Phe Phe Asn Leu Ser Leu 
            20                  25      


<210>  20
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  20

Met Tyr Cys Ser Glu Val Gly Phe Cys Ser Glu Val Ala Pro Thr Glu 
1               5                   10                  15      


Ile Phe Asn Ala Gly Leu Val Val 
            20                  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  21

Met Leu Asp Gln Asp Ile Pro Met Val Gln Pro Leu Leu Lys Val Arg 
1               5                   10                  15      


Leu Phe Asn Asp 
            20  


<210>  22
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  SITE
<222>  (14)..(14)
<223>  Xaa is P - Serine

<400>  22

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Leu Thr Xaa Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  23
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  SITE
<222>  (7)..(7)
<223>  Xaa is P - Serine

<400>  23

Met Ala Pro Arg Gly Phe Xaa Cys Leu Leu Leu Leu Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  24
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  SITE
<222>  (7)..(7)
<223>  Xaa is P - Serine

<220>
<221>  SITE
<222>  (14)..(14)
<223>  Xaa is P - Serine

<400>  24

Met Ala Pro Arg Gly Phe Xaa Cys Leu Leu Leu Leu Thr Xaa Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  25
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  SITE
<222>  (14)..(14)
<223>  Xaa is D - Serine

<400>  25

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Leu Thr Xaa Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  26
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  SITE
<222>  (7)..(7)
<223>  Xaa is D - Serine

<400>  26

Met Ala Pro Arg Gly Phe Xaa Cys Leu Leu Leu Leu Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  27
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  SITE
<222>  (7)..(7)
<223>  Xaa is D - Serine

<220>
<221>  SITE
<222>  (14)..(14)
<223>  Xaa is D - Serine

<400>  27

Met Ala Pro Arg Gly Phe Xaa Cys Leu Leu Leu Leu Thr Xaa Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  SITE
<222>  (14)..(14)
<223>  Xaa is D - Serine

<400>  28

Met Ala Pro Ala Gly Ala Ser Cys Leu Leu Leu Leu Thr Xaa Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  SITE
<222>  (12)..(12)
<223>  Xaa is D - Serine

<400>  29

Pro Ala Gly Ala Ser Cys Leu Leu Leu Leu Thr Xaa Glu Ile Asp Leu 
1               5                   10                  15      


Pro 
    


<210>  30
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  30

Glu Phe Leu Ile Val Ile Lys Ser Met Ala Pro Arg Gly Phe Ala Cys 
1               5                   10                  15      


Leu Leu Leu Leu Thr Ser Glu Ile Asp Leu Pro Val Lys Arg Arg Ala 
            20                  25                  30          


<210>  31
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  31

Glu Phe Leu Ile Val Ile Lys Ser Met Ala Pro Arg Gly Phe Ser Cys 
1               5                   10                  15      


Leu Leu Leu Leu Thr Gly Glu Ile Asp Leu Pro Val Lys Lys Lys Lys 
            20                  25                  30          


<210>  32
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  32

Glu Phe Leu Ile Val Ile Lys Ser Met Ala Pro Arg Gly Phe Ser Ala 
1               5                   10                  15      


Leu Leu Leu Leu Thr Ser Glu Ile Asp Leu Pro Val Lys Arg Arg Ala 
            20                  25                  30          


<210>  33
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  33

Met Ala Pro Arg Gly Phe Ser Ala Leu Leu Leu Leu Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  34
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide


<220>
<221>  SITE
<222>  (7)..(7)
<223>  Xaa is D - Serine

<220>
<221>  SITE
<222>  (14)..(14)
<223>  Xaa is D - Serine

<400>  34

Met Ala Pro Arg Gly Phe Xaa Cys Leu Leu Leu Leu Thr Xaa Glu Ile 
1               5                   10                  15      


Asp Pro Pro Val Lys Arg Arg Ala 
            20                  


<210>  35
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  35

Met Ala Pro Arg Gly Phe Ala Cys Leu Leu Leu Leu Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  36

Pro Arg Gly Phe Ala Cys Leu Leu Leu Leu Thr Ser Glu Ile Asp Leu 
1               5                   10                  15      


Pro 
    


<210>  37
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  37

Tyr Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Leu Thr Gly Glu 
1               5                   10                  15      


Ile Asp Leu Pro Val Lys Lys Lys Lys 
            20                  25  


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  38

Glu Phe Leu Ile Val Ile Lys Ser 
1               5               


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Humanin Polypeptide

<400>  39

Pro Arg Gly Phe Ser Cys Leu Leu Leu Leu Thr Gly Glu Ile Asp Leu 
1               5                   10                  15      


Pro 
    


