                          SEQUENCE LISTING

<110>  Bayer CropScience AG
        
<120>  HPPD VARIANTS AND METHOD OF USE

<130>  BCS151036

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  358
<212>  PRT
<213>  Pseudomonas fluorescens


<220>
<221>  4-hydroxyphenylpyruvate dioxygenase (HPPD; Pseudomonas 
       fluorescens)
<222>  (1)..(358)


<400>  1

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Gly 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  2
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  2

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Ala Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  3
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  3

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Gly 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  4
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  4

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Gly 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  5
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  5

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Gly 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  6
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  6

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  7
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  7

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  8
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  8

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  9
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  9

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  10
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  10

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  11
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  11

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  12
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  12

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  13
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  13

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  14
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  14

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  15
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  15

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  16
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  16

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  17
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  17

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  18
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  18

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  19
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  19

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  20
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  20

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  21
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  21

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  22
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  22

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  23
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  23

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  24
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  24

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  25
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  25

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  26
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  26

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  27
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  27

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  28
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  28

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  29
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  29

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  30
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  30

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  31
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  31

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  32
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  32

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Arg Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  33
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  33

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Arg Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  34
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  34

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Arg Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  35
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  35

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Arg Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  36
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  36

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  37
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  37

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Arg Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  38
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  38

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Val Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  39
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  39

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Leu Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  40
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  40

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Met Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  41
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  41

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ser Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  42
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  42

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Thr Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  43
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  43

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  44
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  44

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Leu Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  45
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  45

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Arg Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  46
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  46

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Met Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  47
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  47

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu His Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  48
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  48

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp His Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  49
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  49

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Ile Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  50
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  50

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Pro Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  51
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  51

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Leu Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  52
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  52

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Ser Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  53
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  53

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Val Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  54
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  54

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Ala Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  55
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  55

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Glu Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  56
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  56

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Arg Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  57
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  57

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Thr Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  58
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  58

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Pro Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  59
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  59

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Arg Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  60
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  60

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  61
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  61

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Pro Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  62
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  62

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Arg Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  63
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  63

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  64
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  64

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu His Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  65
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  65

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Lys Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  66
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  66

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Ser Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  67
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  67

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Lys Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  68
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  68

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Leu Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  69
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  69

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Gln Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  70
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  70

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  71
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  71

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  72
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  72

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Arg Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  73
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  73

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  74
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  74

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Leu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  75
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  75

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Pro Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  76
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  76

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Arg Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  77
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  77

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  78
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  78

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Ala Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  79
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  79

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Phe Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  80
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  80

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Gly Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  81
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  81

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Ala Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  82
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  82

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Glu Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  83
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  83

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Gly Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  84
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  84

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Leu Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  85
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  85

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Met Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  86
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  86

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Gln Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  87
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  87

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ala Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  88
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  88

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  89
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  89

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  90
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  90

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  91
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  91

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Arg Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  92
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  92

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ala Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  93
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  93

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  94
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  94

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  95
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  95

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Arg Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Arg Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  96
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  96

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  97
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  97

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Arg Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Ser Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  98
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  98

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Ser Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Arg Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  99
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  99

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Val Lys Arg Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  100
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  100

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Leu Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  101
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  101

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Leu Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Arg Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  102
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  102

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Leu Thr Ala Pro Arg Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Arg Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  103
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  103

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Leu Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Arg Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  104
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  104

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Leu Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  105
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  105

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Leu Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Arg Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  106
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  106

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Leu Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Pro Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  107
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  107

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Val Lys Arg Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  108
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  108

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Met Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly His Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  109
<211>  1074
<212>  DNA
<213>  Pseudomonas fluorescens

<220>
<221>  CDS 4-hydroxyphenylpyruvate dioxygenase (HPPD)
<222>  (1)..(1074)

<400>  109
atggcagatc tatacgaaaa cccaatgggc ctgatgggct ttgaattcat cgaattcgcg       60

tcgccgacgc cgggtaccct ggagccgatc ttcgagatca tgggcttcac caaagtcgcg      120

acccaccgtt ccaagaacgt gcacctgtac cgccagggcg agatcaacct gatcctcaac      180

aacgagccca acagcatcgc ctcctacttt gcggccgaac acggcccgtc ggtgtgcggc      240

atggcgttcc gcgtgaagga ctcgcaaaag gcctacaacc gcgccctgga actcggcgcc      300

cagccgatcc atattgacac cgggccgatg gaattgaacc tgccggcgat caagggcatc      360

ggcggcgcgc cgttgtacct gatcgaccgt ttcggcgaag gcagctcgat ctacgacatc      420

gacttcgtgt acctcgaagg tgtggagcgc aatccggtcg gtgcaggtct caaagtcatc      480

gaccacctga cccacaacgt ctatcgcggc cgcatggtct actgggccaa cttctacgag      540

aaattgttca acttccgtga agcgcgttac ttcgatatca agggcgagta caccggcctg      600

acttccaagg ccatgagtgc gccggacggc atgatccgca tcccgctgaa cgaagagtcg      660

tccaagggcg cggggcagat cgaagagttc ctgatgcagt tcaacggcga aggcatccag      720

cacgtggcgt tcctcaccga cgacctggtc aagacctggg acgcgttgaa gaaaatcggc      780

atgcgcttca tgaccgcgcc gccagacact tattacgaaa tgctcgaagg ccgcctgcct      840

gaccacggcg agccggtgga tcaactgcag gcacgcggta tcctgctgga cggatcttcc      900

gtggaaggcg acaaacgcct gctgctgcag atcttctcgg aaaccctgat gggcccggtg      960

ttcttcgaat tcatccagcg caagggcgac gatgggtttg gcgaggggaa cttcaaggcg     1020

ctgttcgagt ccatcgaacg tgaccaggtg cgtcgtggtg tattgaccgc cgat           1074

