                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado
       ZHU, Yuwen
       EDIL, Barish
       SCHULICK, Richard  D
       PANICCIA, Alessandro
       KOENIG, Michelle
       SCHULICK, Alexander C
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING T-CELL MEDIATED IMMUNE 
       RESPONSE

<130>  UNCO-002001WO 300978-2048

<150>  62/370,512
<151>  2016-08-03

<150>  62/213,305
<151>  2015-09-02

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein

<400>  1

Met Arg Thr Glu Ala Gln Val Pro Ala Leu Gln Pro Pro Glu Pro Gly 
1               5                   10                  15      


Leu Glu Gly Ala Met Gly His Arg Thr Leu Val Leu Pro Trp Val Leu 
            20                  25                  30          


Leu Thr Leu Cys Val Thr Ala Gly Thr Pro Glu Val Trp Val Gln Val 
        35                  40                  45              


Arg Met Glu Ala Thr Glu Leu Ser Ser Phe Thr Ile Arg Cys Gly Phe 
    50                  55                  60                  


Leu Gly Ser Gly Ser Ile Ser Leu Val Thr Val Ser Trp Gly Gly Pro 
65                  70                  75                  80  


Asn Gly Ala Gly Gly Thr Thr Leu Ala Val Leu His Pro Glu Arg Gly 
                85                  90                  95      


Ile Arg Gln Trp Ala Pro Ala Arg Gln Ala Arg Trp Glu Thr Gln Ser 
            100                 105                 110         


Ser Ile Ser Leu Ile Leu Glu Gly Ser Gly Ala Ser Ser Pro Cys Ala 
        115                 120                 125             


Asn Thr Thr Phe Cys Cys Lys Phe Ala Ser Phe Pro Glu Gly Ser Trp 
    130                 135                 140                 


Glu Ala Cys Gly Ser Leu Pro Pro Ser Ser Asp Pro Gly Leu Ser Ala 
145                 150                 155                 160 


Pro Pro Thr Pro Ala Pro Ile Leu Arg Ala Asp Leu Ala Gly Ile Leu 
                165                 170                 175     


Gly Val Ser Gly Val Leu Leu Phe Gly Cys Val Tyr Leu Leu His Leu 
            180                 185                 190         


Leu Arg Arg His Lys His Arg Pro Ala Pro Arg Leu Gln Pro Ser Arg 
        195                 200                 205             


Thr Ser Pro Gln Ala Pro Arg Ala Arg Ala Trp Ala Pro Ser Gln Ala 
    210                 215                 220                 


Ser Gln Ala Ala Leu His Val Pro Tyr Ala Thr Ile Asn Thr Ser Cys 
225                 230                 235                 240 


Arg Pro Ala Thr Leu Asp Thr Ala His Pro His Gly Gly Pro Ser Trp 
                245                 250                 255     


Trp Ala Ser Leu Pro Thr His Ala Ala His Arg Pro Gln Gly Pro Ala 
            260                 265                 270         


Ala Trp Ala Ser Thr Pro Ile Pro Ala Arg Gly Ser Phe Val Ser Val 
        275                 280                 285             


Glu Asn Gly Leu Tyr Ala Gln Ala Gly Glu Arg Pro Pro His Thr Gly 
    290                 295                 300                 


Pro Gly Leu Thr Leu Phe Pro Asp Pro Arg Gly Pro Arg Ala Met Glu 
305                 310                 315                 320 


Gly Pro Leu Gly Val Arg 
                325     


<210>  2
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  2
gatcgactta gggcgattga tttagcggcc gcgaattcgc ccttctgcaa ccggtgtaca       60

ttccgacatc gtgatcacac agtctctgca accggtgtac attccgacat tgagatgaca      120

cagtctccag ccaccctgtc tgtgactcca ggagatagag tctctctttc ctgcagggcc      180

agccagagta ttagagacta cttacactgg tatcaacaaa aatcacatga gtctccaagg      240

cttctcatca aatatgtttc ccaatccatt tctgggatcc cctccaggtt cagtggcagt      300

ggatcagggt cagagttcac tctcagtatc aacagtgtgg aacctgaaga tgttggagta      360

tattactgtc aaaatggtca cagccttcct ctcacgttcg gctcggggac aaagttggaa      420

ataaaacgta cggtggcaag ggcgaattcg tttaaacctg caggactagt ccctttagtg      480

agggttaatt ctgagcttgg cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta      540

tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc      600

ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg      660

aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag gcggtttgcg      720

tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg      780

gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa      840

cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc      900

gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc      960

aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctgtaaa     1020

gctccctcgt gcgctctcct gtttccgacc ctgcccgctt taccgggata ccctgtccgc     1080

cctttttctc ccttcgggga aagcgtgcgc tttctcatag ctcaacgctg gtagattaat     1140

ctctcaggtt ccggggttgt gtta                                            1164


<210>  3
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  3

Asp Ile Glu Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Arg Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Glu Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110 


<210>  4
<211>  383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  4
gcaaccggtg tacattccga ggtgcaactg cagcagtcag gggctgaact ggtgaggtct       60

ggggcctcag tgaagatgtc ctgcaaggtt aatgactaca catttaccaa ttacaatatg      120

cactggttaa ggcagacacc tggccagggc ctggaatgga ttggatatat ttatcctgga      180

aatggcgata ctaactacaa tcagaaattc aagggcaagg ccacattgac tgcagacaca      240

tcctccagca cagcctacat gcagatcatc agcctgacat ctgaagaccc tgcggtctat      300

ttctgtgcaa gacagggaat tcattactat tacatcgatg tctggggcgc agggaccacg      360

gtcaccgtct cctcagggtc gac                                              383


<210>  5
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  5

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Val Asn Asp Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asn Met His Trp Leu Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Ile Ile Ser Leu Thr Ser Glu Asp Pro Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Gly Ile His Tyr Tyr Tyr Ile Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly 
        115                 120 


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  6

Asp Tyr Thr Phe Thr Asn Tyr Asn Met His 
1               5                   10  


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  7

Tyr Ile Tyr Pro Gly Asn Gly Asp Thr Asn Tyr Asn Gln 
1               5                   10              


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  8

Gln Gly Ile His Tyr Tyr Tyr Ile Asp Val 
1               5                   10  


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  9

Arg Ala Ser Gln Ser Ile Arg Asp Tyr Leu His 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  10

Tyr Val Ser Gln Ser Ile Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  11

Gln Asn Gly His Ser Leu Pro Leu Thr 
1               5                   


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  12

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  13

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic tag

<400>  14

Glu Glu Glu Glu Glu Glu 
1               5       


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  15

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic tag

<400>  16

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  17

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  18

His His His His His His 
1               5       


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  19

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  20

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  21
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  21

Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  22

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  23

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  24

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  25

Cys Cys Pro Gly Cys Cys 
1               5       


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  26

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  27

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  28

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  29

Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Ala Glu 
1               5                   10                  15      


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tag

<400>  30

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10              


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant sequence

<400>  31
tgcacgtggc agctttgtct ctgtt                                             25


<210>  32
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  32

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asp 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ser Gly Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  33
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  33

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanzed antibody

<400>  34

Ser Asp Trp Met His 
1               5   


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  35

Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  36

Gly Ser Ser Gly Ser Trp Phe Ala Tyr 
1               5                   


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  37

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  38

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  39

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  40

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  41

Lys Ser Ser Gln Ser Leu Leu Asn Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  42

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  43

Trp Gln Gly Thr His Phe Pro Arg Thr 
1               5                   


<210>  44
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  44

Glu Ala Thr Glu Leu Ser Ser Phe Thr Ile Arg Cys Gly Phe Leu Gly 
1               5                   10                  15      


Ser Gly Ser Ile Ser Leu Val Thr Val Ser Trp Gly Gly Pro Asn Gly 
            20                  25                  30          


Ala Gly Gly Thr Thr Leu Ala Val Leu His Pro Glu Arg Gly Ile Arg 
        35                  40                  45              


Gln Trp Ala Pro Ala Arg Gln Ala Arg Trp Glu Thr Gln Ser Ser Ile 
    50                  55                  60                  


Ser Leu Ile Leu Glu Gly Ser Gly Ala Ser Ser Pro Cys Ala Asn Thr 
65                  70                  75                  80  


Thr Phe Cys Cys Lys Phe Ala Ser Phe Pro Glu Gly Ser Trp Glu Ala 
                85                  90                  95      


<210>  45
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  45

Met Arg Thr Glu Ala Gln Val Pro Ala Leu Gln Pro Pro Glu Pro Gly 
1               5                   10                  15      


Leu Glu Gly Ala Met Gly His Arg Thr Leu Val Leu Pro Trp Val Leu 
            20                  25                  30          


Leu Thr Leu Cys Val Thr Ala Gly Thr Pro Glu Val Trp Val Gln Val 
        35                  40                  45              


Arg Met Glu Ala Thr Glu Leu Ser Ser Phe Thr Ile Arg Cys Gly Phe 
    50                  55                  60                  


Leu Gly Ser Gly Ser Ile Ser Leu Val Thr Val Ser Trp Gly Gly Pro 
65                  70                  75                  80  


Asn Gly Ala Gly Gly Thr Thr Leu Ala Val Leu His Pro Glu Arg Gly 
                85                  90                  95      


Ile Arg Gln Trp Ala Pro Ala Arg Gln Ala Arg Trp Glu Thr Gln Ser 
            100                 105                 110         


Ser Ile Ser Leu Ile Leu Glu Gly Ser Gly Ala Ser Ser Pro Cys Ala 
        115                 120                 125             


Asn Thr Thr Phe Cys Cys Lys Phe Ala Ser Phe Pro Glu Gly Ser Trp 
    130                 135                 140                 


Glu Ala Cys Gly Ser Leu Pro Pro Ser Ser Asp Pro Gly Leu Ser Ala 
145                 150                 155                 160 


<210>  46
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein

<400>  46

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  47
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  47

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210>  48
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  48

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  49
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  49

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  50
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  50

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp 
            100                 105                 110         


Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala Ser 
        115                 120                 125             


Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp Leu 
    130                 135                 140                 


Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly Glu 
145                 150                 155                 160 


Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr 
                165                 170                 175     


Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser 
            180                 185                 190         


Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro 
        195                 200                 205             


Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly 
    210                 215             


<210>  51
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant sequence

<400>  51
gccaccatgg gatggagctg tatcatcctc ttcttggtag caacagctac aggtgtccac       60

gaggtgcaac tgcagcagtc aggggctgaa ctggtgaggt ctggggcctc agtgaagatg      120

tcctgcaagg ttaatgacta cacatttacc aattacaata tgcactggtt aaggcagaca      180

cctggccagg gcctggaatg gattggatat atttatcctg gaaatggcga tactaactac      240

aatcagaaat tcaagggcaa ggccacattg actgcagaca catcctccag cacagcctac      300

atgcagatca tcagcctgac atctgaagac cctgcggtct atttctgtgc aagacaggga      360

attcattact attacatcga tgtctggggc gcagggacca cggtcaccgt ctcctcaggg      420

ggtggtggtg gttctggtgg tggtggttct ggtggtggtg gttctgacat tgagatgaca      480

cagtctccag ccaccctgtc tgtgactcca ggagatagag tctctctttc ctgcagggcc      540

agccagagta ttagagacta cttacactgg tatcaacaaa aatcacatga gtctccaagg      600

cttctcatca aatatgtttc ccaatccatt tctggcatcc cctccaggtt cagtggcagt      660

ggatcagggt cagagttcac tctcagtatc aacagtgtgg aacctgaaga tgttggagta      720

tattactgtc aaaatggtca cagccttcct ctcacgttcg gctcggggac aaagttggaa      780

ataaaacgta cggtgaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact      960

tgtggggtcc ttctcctgtc actggttatc accaggagta agaggagcag gctcctgcac     1020

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc     1080

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca     1140

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1200

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1260

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1320

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1380

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1440

gccctgcccc ctcgcaaacc ggtttaa                                         1467


<210>  52
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  52

Met Arg Thr Glu Ala Gln Val Pro Ala Leu Gln Pro Pro Glu Pro Gly 
1               5                   10                  15      


Leu Glu Gly Ala Met Gly His Arg Thr Leu Val Leu Pro Trp Val Leu 
            20                  25                  30          


Leu Thr Leu Cys Val Thr Ala Gly Thr Pro Glu Val Trp Val Gln Val 
        35                  40                  45              


Arg Met Glu Ala Thr Glu Leu Ser Ser Phe Thr Ile Arg Cys Gly Phe 
    50                  55                  60                  


Leu Gly Ser Gly Ser Ile Ser Leu Val Thr Val Ser Trp Gly Gly Pro 
65                  70                  75                  80  


Asn Gly Ala Gly Gly Thr Thr Leu Ala Val Leu His Pro Glu Arg Gly 
                85                  90                  95      


Ile Arg Gln Trp Ala Pro Ala Arg Gln Ala Arg Trp Glu Thr Gln Ser 
            100                 105                 110         


Ser Ile Ser Leu Ile Leu Glu Gly Ser Gly Ala Ser Ser Pro Cys Ala 
        115                 120                 125             


Asn Thr Thr Phe Cys Cys Lys Phe Ala Ser Phe Pro Glu Gly Ser Trp 
    130                 135                 140                 


Glu Ala Cys Gly Ser Leu Pro Pro Ser Ser Asp Pro Gly Leu Ser Ala 
145                 150                 155                 160 


Arg Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
                165                 170                 175     


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
            180                 185                 190         


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
        195                 200                 205             


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
    210                 215                 220                 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
225                 230                 235                 240 


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
                245                 250                 255     


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
            260                 265                 270         


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
        275                 280                 285             


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
    290                 295                 300                 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
305                 310                 315                 320 


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
                325                 330                 335     


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
            340                 345                 350         


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
        355                 360                 365             


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
    370                 375                 380                 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
385                 390                 


<210>  53
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln 
    


<210>  54
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  54

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln Ala Arg Trp 
            20  


<210>  55
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  55

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln Ala Arg Trp Glu Thr Gln Ser Ser 
            20                  25  


<210>  56
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln Ala Arg Trp Glu Thr Gln Ser Ser Ile Ser 
            20                  25          


<210>  57
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  57

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln Ala Arg Trp Glu Thr Gln Ser Ser Ile Ser Leu 
            20                  25              


<210>  58
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant sequence

<400>  58
acgtggcagc tttgtctctg ttgag                                             25


<210>  59
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant Sequence

<400>  59
tggcagcttt gtctctgttg agaat                                             25


<210>  60
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant sequence

<400>  60
gctttgtctc tgttgagaat ggact                                             25


<210>  61
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  61

Val Gln Val Arg Met Glu Ala Thr Glu Leu Ser Ser Phe Thr Ile Arg 
1               5                   10                  15      


Cys Gly Phe Leu Gly Ser Gly Ser Ile Ser Leu Val Thr Val Ser Trp 
            20                  25                  30          


Gly Gly Pro Asn Gly Ala Gly Gly Thr Thr Leu Ala Val Leu His Pro 
        35                  40                  45              


Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg Gln Ala Arg Trp Glu 
    50                  55                  60                  


Thr Gln Ser Ser Ile Ser Leu Ile Leu Glu Gly Ser Gly Ala Ser Ser 
65                  70                  75                  80  


Pro Cys Ala Asn Thr Thr Phe Cys Cys Lys Phe Ala Ser Phe Pro Glu 
                85                  90                  95      


Gly Ser Trp Glu 
            100 


<210>  62
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  62

Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly Thr Val Glu 
1               5                   10                  15      


Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr Ile Ser Leu 
            20                  25                  30          


Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln Asn Val Ala 
        35                  40                  45              


Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro Lys Pro Gly 
    50                  55                  60                  


Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr Gly Gln Asp 
65                  70                  75                  80  


Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His Gly Leu Thr 
                85                  90                  95      


Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr Phe Pro Lys 
            100                 105                 110         


Gly Ser Val Arg 
        115     


<210>  63
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  63

Val Gln Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr 
1               5                   10                  15      


Leu Pro Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser 
            20                  25                  30          


Gln Leu Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe 
        35                  40                  45              


His Gln Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Lys Arg Leu Glu 
    50                  55                  60                  


Phe Val Ala Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg 
65                  70                  75                  80  


Met Phe Gly Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe 
                85                  90                  95      


Val Thr Phe Pro Gln Gly Ser Arg Ser 
            100                 105 


<210>  64
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  64

Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile 
1               5                   10                  15      


Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val Thr Gln Val Asn 
            20                  25                  30          


Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly 
        35                  40                  45              


Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala Pro Gly Pro Gly 
    50                  55                  60                  


Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr 
65                  70                  75                  80  


Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr Thr 
                85                  90              


<210>  65
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  65

Val Asn Thr Glu Glu Asn Val Tyr Ala Thr Leu Gly Ser Asp Val Asn 
1               5                   10                  15      


Leu Thr Cys Gln Thr Gln Thr Val Gly Phe Phe Val Gln Met Gln Trp 
            20                  25                  30          


Ser Lys Val Thr Asn Lys Ile Asp Leu Ile Ala Val Tyr His Pro Gln 
        35                  40                  45              


Tyr Gly Phe Tyr Cys Ala Thr Gly Arg Pro Cys Glu Ser Leu Val Thr 
    50                  55                  60                  


Phe Thr Glu Thr Pro Glu Asn Gly Ser Lys Trp Thr Leu His Leu Arg 
65                  70                  75                  80  


Asn Met Ser Cys Ser Val Ser Gly Arg Tyr Glu Cys Met Leu Val Leu 
                85                  90                  95      


Tyr Pro Glu Gly Ile Gln Thr 
            100             


<210>  66
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  66

Val Gln Val Asn Asp Ser Met Tyr Gly Phe Ile Gly Thr Asp Val Val 
1               5                   10                  15      


Leu His Cys Ser Phe Ala Asn Pro Leu Pro Ser Val Lys Ile Thr Gln 
            20                  25                  30          


Val Thr Trp Gln Lys Ser Thr Asn Gly Ser Lys Gln Asn Val Ala Ile 
        35                  40                  45              


Tyr Asn Pro Ser Met Gly Val Ser Val Leu Ala Pro Tyr Arg Glu Arg 
    50                  55                  60                  


Val Glu Phe Leu Arg Pro Ser Phe Thr Asp Gly Thr Ile Arg Leu Ser 
65                  70                  75                  80  


Arg Leu Glu Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Phe Ala Thr 
                85                  90                  95      


Phe Pro Thr Gly Asn Arg Glu 
            100             


<210>  67
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  67

Ile Ile Val Glu Pro His Val Thr Ala Val Trp Gly Lys Asn Val Ser 
1               5                   10                  15      


Leu Lys Cys Leu Ile Glu Val Asn Glu Thr Ile Thr Gln Ile Ser Trp 
            20                  25                  30          


Glu Lys Ile His Gly Lys Ser Ser Gln Thr Val Ala Val His His Pro 
        35                  40                  45              


Gln Tyr Gly Phe Ser Val Gln Gly Glu Tyr Gln Gly Arg Val Leu Phe 
    50                  55                  60                  


Lys Asn Tyr Ser Leu Asn Asp Ala Thr Ile Thr Leu His Asn Ile Gly 
65                  70                  75                  80  


Phe Ser Asp Ser Gly Lys Tyr Ile Cys Lys Ala Val Thr Phe Pro Leu 
                85                  90                  95      


Gly Asn Ala Gln 
            100 


<210>  68
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  68

Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala Lys 
1               5                   10                  15      


Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln Val 
            20                  25                  30          


Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala Leu 
        35                  40                  45              


Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly Arg 
    50                  55                  60                  


Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val Leu 
65                  70                  75                  80  


Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg Val 
                85                  90                  95      


Ser Thr Phe Pro Ala Gly Ser Phe Gln 
            100                 105 


<210>  69
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  69

Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn Met Ser 
1               5                   10                  15      


Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val Glu Trp 
            20                  25                  30          


Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser Pro Thr 
        35                  40                  45              


His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr Phe Leu 
    50                  55                  60                  


Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg Asn Ala 
65                  70                  75                  80  


Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr Thr Tyr 
                85                  90                  95      


Pro Gln Gly Thr Trp Gln 
            100         


<210>  70
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Ala Gln Val Pro Ala Leu Gln Pro Pro 
1               5                   10  


<210>  71
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  71

Val Leu Pro Trp Val Leu Leu Thr Leu Cys Val Thr Ala Gly Thr Pro 
1               5                   10                  15      


Glu Val Trp Val Gln Val Arg Met Glu Ala 
            20                  25      


<210>  72
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  72

Pro Trp Val Leu Leu Thr Leu Cys Val Thr Ala Gly Thr Pro Glu Val 
1               5                   10                  15      


Trp Gln Val Arg Met Glu Ala Thr Glu Leu Ser Ser Phe Thr Ile Arg 
            20                  25                  30          


<210>  73
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  73

Leu Cys Val Thr Ala Gly Thr 
1               5           


<210>  74
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  74

Val Thr Val Ser Trp Gly Gly Pro Asn Gly 
1               5                   10  


<210>  75
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln 
    


<210>  76
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln Ala Arg Trp 
            20  


<210>  77
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  77

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln Ala Arg Trp Glu Thr Gln Ser Ser 
            20                  25  


<210>  78
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln Ala Arg Trp Glu Thr Gln Ser Ser Ile Ser 
            20                  25          


<210>  79
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp Ala Pro Ala Arg 
1               5                   10                  15      


Gln Ala Arg Trp Glu Thr Gln Ser Ser Ile Ser Leu 
            20                  25              


<210>  80
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  80

Leu Ser Ala Arg Ser Pro Arg Gly Pro 
1               5                   


<210>  81
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  81

Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
1               5                   10      


<210>  82
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  82

Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
1               5                   10  


<210>  83
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  83

Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
1               5                   10          


<210>  84
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  84

Phe Ile Phe Pro Pro Lys Ile Lys Asp 
1               5                   


<210>  85
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  85

Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
1               5                   10      


<210>  86
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  86

Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
1               5                   10          


<210>  87
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  87

Ile Phe Pro Pro Lys Ile Lys Asp 
1               5               


<210>  88
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  88

Phe Pro Pro Lys Ile Lys Asp 
1               5           


<210>  89
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  89

Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
1               5                   10  


<210>  90
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  90

Pro Pro Lys Ile Lys Asp Val Leu Met 
1               5                   


<210>  91
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  91

Pro Lys Ile Lys Asp Val Leu 
1               5           


<210>  92
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ile Ser Leu Ser Pro Val Thr 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  93

Ile Ser Leu Ser Pro Ile Val Thr 
1               5               


<210>  94
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  94

Val Ser Glu Asp Asp Pro Asp Val Gln 
1               5                   


<210>  95
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  95

Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 
1               5                   10                  


<210>  96
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  96

Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
1               5                   10                  15      


Gly Lys Glu Phe Lys Cys Lys 
            20              


<210>  97
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  97

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
1               5                   10              


<210>  98
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  98

Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
1               5                   10                  15      


Lys Glu 
        


<210>  99
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  99

Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
1               5                   10      


<210>  100
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  100

Pro Ile Gln His Gln Asp Trp 
1               5           


<210>  101
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  101

Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
1               5                   10          


<210>  102
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  102

Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
1               5                   10                  15  


<210>  103
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  103

Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
1               5                   10                  


<210>  104
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  104

Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
1               5                   10                  15  


<210>  105
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  105

Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
1               5                   10                  15      


Glu Met Thr Lys Lys Gln Val Thr 
            20                  


<210>  106
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  106

Tyr Val Leu Pro Pro Pro Glu Glu 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  107

Lys Lys Gln Val Thr Leu Thr Cys 
1               5               


<210>  108
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  108

Val Thr Asp Phe Met Pro Glu Asp Ile 
1               5                   


<210>  109
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  109

Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
1               5                   10  


<210>  110
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  110

Asp Phe Met Pro Glu Asp Ile Tyr 
1               5               


<210>  111
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  111

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
1               5                   10  


<210>  112
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  112

Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
1               5                   10              


<210>  113
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  113

Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
1               5                   10          


<210>  114
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  114

Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
1               5                   10      


<210>  115
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  115

Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
1               5                   10  


<210>  116
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  116

Asn Tyr Lys Asn Thr Glu Pro Val Leu 
1               5                   


<210>  117
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  117

Lys Asn Thr Glu Pro Val Leu 
1               5           


<210>  118
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  118

Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
1               5                   10                  15      


Leu Arg Val Glu 
            20  


<210>  119
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  119

Asp Ser Asp Gly Ser Tyr Phe 
1               5           


<210>  120
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  120

Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
1               5                   10                  15      


<210>  121
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  121

Ser Val Val His Glu Gly Leu His 
1               5               


<210>  122
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant sequence

<400>  122
tgcacgtggc agctttgtct ctgtt                                             25


