                         SEQUENCE LISTING

<110>  Regents of the University of Minnesota
       New York University
 
<120>  METHODS AND COMPOSITIONS FOR INCREASING THE SUPPRESSIVE FUNCTION 
       OF REGULATORY T-CELLS (TREGS)

<130>  09531-0359WO1

<150>  62/214,680
<151>  2015-09-04

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  9659
<212>  DNA
<213>  Homo sapiens

<400>  1
tttgtgttac ataattgcct ttcatttgaa ctcattaatc aaattggggt ttttaagcaa       60

cacctaatta attctttaac tggctcatat tataccttta atgacttcca ccagggtaaa      120

aaccactgat cactgagttc tattttgaaa ctacggacgt cgagtttcct ctttcaccca      180

gaattttcag atcttgttta aaaagttggg tgtggtttca tggggggagg gggaagagcg      240

agaggagacc agagggacgg gggcggggac tctgcaagaa aaaccttccc ggtgcaatcg      300

tgatctggga ggcccacgta tggcgcctct ccaaaggctg cagaagtttc ttgctaacaa      360

aaagtccgca cattcgagca aagacaggct ttagcgagtt attaaaaact taggggcgct      420

cttgtccccc acagggcccg accgcacaca gcaaggcgat ggcccagctg taagttggta      480

gcactgagaa ctagcagcgc gcgcggagcc cgctgagact tgaatcaatc tggtctaacg      540

gtttccccta aaccgctagg agccctcaat cggcgggaca gcagggcgcg gtgagtcacc      600

gccggtgact aagcgacccc acccctctcc ctcgggcttt cctctgccac cgccgtctcg      660

caactcccgc cgtccgaagc tggactgagc ccgttaggtc cctcgacaga acctcccctc      720

cccccaacat ctctccgcca aggcaagtcg atggacagag gcgcgggccg gagcagcccc      780

cctttccaag cgggcggcgc gcgaggctgc ggcgaggcct gagccctgcg ttcctgcgct      840

gtgcgcgccc ccaccccgcg ttccaatctc aggcgctctt tgtttctttc tccgcgactt      900

cagatctgag ggattcctta ctctttcctc ttcccgctcc tttgcccgcg ggtctccccg      960

cctgaccgca gccccgagac cgccgcgcac ctcctcccac gcccctttgg cgtggtgcca     1020

ccggacccct ctggttcagt cccaggcgga cccccccctc accgcgcgac cccgcctttt     1080

tcagcacccc agggtgagcc cagctcagac tatcatccgg aaagccccca aaagtcccag     1140

cccagcgctg aagtaacggg accatgccca gtcccaggcc ccggagcagg aaggctcgag     1200

ggcgccccca ccccacccgc ccaccctccc cgcttctcgc taggtcccta ttggctggcg     1260

cgctccgcgg ctgggatggc agtgggaggg gaccctcttt cctaacgggg ttataaaaac     1320

agcgccctcg gcggggtcca gtcctctgcc actctcgctc cgaggtcccc gcgccagaga     1380

cgcagccgcg ctcccaccac ccacacccac cgcgccctcg ttcgcctctt ctccgggagc     1440

cagtccgcgc caccgccgcc gcccaggcca tcgccaccct ccgcagccat gtccaccagg     1500

tccgtgtcct cgtcctccta ccgcaggatg ttcggcggcc cgggcaccgc gagccggccg     1560

agctccagcc ggagctacgt gactacgtcc acccgcacct acagcctggg cagcgcgctg     1620

cgccccagca ccagccgcag cctctacgcc tcgtccccgg gcggcgtgta tgccacgcgc     1680

tcctctgccg tgcgcctgcg gagcagcgtg cccggggtgc ggctcctgca ggactcggtg     1740

gacttctcgc tggccgacgc catcaacacc gagttcaaga acacccgcac caacgagaag     1800

gtggagctgc aggagctgaa tgaccgcttc gccaactaca tcgacaaggt gcgcttcctg     1860

gagcagcaga ataagatcct gctggccgag ctcgagcagc tcaagggcca aggcaagtcg     1920

cgcctggggg acctctacga ggaggagatg cgggagctgc gccggcaggt ggaccagcta     1980

accaacgaca aagcccgcgt cgaggtggag cgcgacaacc tggccgagga catcatgcgc     2040

ctccgggaga agtaaggctg cgcccatgca agtagctggg cctcgggagg gggctggagg     2100

gagaggggaa cgcccccccg gcccccgcga gagctgccac gcccttgggg atgtggccgg     2160

ggggaggcct gccagggaga cagcggagag cggggctgtg gctgtggtgg cgcagccccg     2220

cccagaaccc agaccttgca gttcgcattt cctcctctgt ccccacacat tgcccaagga     2280

cgctccgttt caagttacag atttcttaaa actaccactt tgtgtgcagt tgaaggccct     2340

tgggcacaat gagagccagt cctccaaact ttcagaaagt ttcctgcccc ttctggcagg     2400

ctgccaatca ccgggcggga gaaggaagga ggggaaggcg gtggagggag cgagacaaag     2460

ggatggtccc tcgggggcgg ggatggcggg gctgtcctgt aggtctgtgc ggccaccgtg     2520

attgcccctc tgcgcggtgc ccgaagtccc gctgaaacct gccgagggca gcaggtctga     2580

aagctgcagg cgctagttgc gcggaggtgg cgcagctgct ctggaggcgc agagcgaata     2640

cgtggtgttt gggtgtggcc gccccgcccc tggcggtttc ctcgttcccc tttggttaat     2700

gcgcaactgt ttcagattgc aggaggagat gcttcagaga gaggaagccg aaaacaccct     2760

gcaatctttc agacaggttt gtagactctc ttcccactcg cagccgcctg accccaccca     2820

acacaaccca cgagcaattc taaaagttgc ttaactcacg tctaaaaagt gcaaaacttc     2880

agggctgcgc gtaaagccct ctagtggcgg gaagaccaca ggttggagct tctcatgatt     2940

agaaaaatat taataaaacc ccttgagcga tttttttttt ttttttgaga cggagtctta     3000

ctctgtcgcc caggctggag tgcagtggcg agatcttggc tcactgcatc ctccgcctcc     3060

cgggttcaag cgatccttga atgatttcta agcagttcct tgggacataa agaaaaatct     3120

tttaactttt tactttgttt cccaaatgtt gcacagtttt gcaacacatt gaccttctgg     3180

tttcgaacgg ttacaatttt agattgtggt ttgccaaagt caagttgctt aatttttaca     3240

aggccacaaa aagcgcaatt atgccctgca gtttaaaatg gaaaacgtgt tggaagataa     3300

gaaaacttag tttccaactg gaatggagcc agcaagtttc ttttcttctt tgcaaattct     3360

attgtgtcat taaagttcga tggaagtatc actatgcaca actattttgt gatctaataa     3420

gggtgaaaag gagccatctg tccccttggc taaggggtat taatggtttc tatgggcttc     3480

actatggaat gtagatacag acattctggc aaatgtggtg gctctggaca gaaataatag     3540

gagtctttgt attcccaggg aagctttgca acaggctaca ttcttactga atatgtaatg     3600

atgtaagcac ggttctaatt ggacacaagt atttgctaac atccgttatc taatatctgg     3660

cccagacttg agaagtaggt aatgtaaaaa gtttttaaag ctacaagcat acctcacatt     3720

ttaaaagtcc tttcttgatt gggttcttgt gttctttagc actcttgcca taaaaaataa     3780

taacagtaat aaacccaagg ctgaaaaact gaattttaac taaagggttt ttgtgcgtgt     3840

tttttttttt tttcaccaaa attagatgga cttacagaat ttttaactta aaattggaat     3900

ccaaaagcca gaagatcccc attatagttt atagttgtat tccctggaat atttactggg     3960

attaactgca aagcactctc agatgaatag tgtagtataa cattttgaaa ctgaaataca     4020

tttaccaaat taatttaacc acagcaatgt gtgtggttca ttttagtcct tgagcatttt     4080

tgattatcat acctgtcatg ttttctgcag tgtagtgagt taacataaaa caacatcaat     4140

acaaaagatc ctctgtttcg agattaagca aaattcctca ttctcttcaa tgtgatagaa     4200

taccacattg atctttcttt ggaggttagt aaaatatctt ttatgtattt ttcagggctt     4260

aacaagtaaa aatcaatgtt ttcatcaagt ctgatctttt tgtcacccac tcttcattca     4320

tttttccact aaggtgatag aaaagtctca acagtttaag accgtaaggc tatgaactcc     4380

aaatataatt gctgacaaga taagcaatcc tcacgcatcc ttttgagagg aaataaaatc     4440

ttagttgcaa gattacatat tctgatttgg aatgctgagc tttttaaatg gaaatataga     4500

aggacggctg aatcagcaaa aatcctttat gtagtttcat tctttgcaag cttgaccagt     4560

cattctgaaa caggctaact gaactgatac agtggcaagt gaaaaagaca tgcctttaca     4620

ggatgagtca aaggagtttt agaagaaaaa tccaccagag aaagccaagc aaatacagtt     4680

cagagttaca tttcttttcc attttttcct gaactgaatc tttggcatgc atatcctgaa     4740

ttgggttatt gaatataaat ctagccttgt acaatggatg ccagatgact acatatttgc     4800

tttggagcct aaggataagt ttcaaaagat ttgagtggag aagaaaagct aaaactcttg     4860

aagcacaagt ttctgttctc catgtactca agtgtacatg aagttgtgaa aatttgtcca     4920

cctctatcat catgttattc catgaaatta caaaacaaat cttaaaaatg ttgtggcata     4980

gattttctag atttaaaaag taattaaatt aaatgaatta ctttattttt tgagacagag     5040

tgtcactctg ttgcccaggc tggagtgcag tggcactatg ttggctcact gcaacctctg     5100

cctcctgggt tgaagaaatt ctcctgcctc aacctcccaa gtagctggga ctacaggcat     5160

gtgccaccac acccagctaa tttttgtatt tttggtagag acggggtttc gccatgttgg     5220

ctaggctggt ctcgaactcc tgacctcaag tgatccaccc gtctcagcct cccaaagtgc     5280

tgggattaca ggcataagcc accatgacca gccttaaaaa gtaattttaa aatatcactg     5340

gtaaaatgtg gattcagtca tgattgagtg cagtttacca tgtgtgtgga catttattta     5400

ttttaaaatt gtctgatcac caccttgagt aaaacacaag cagtcacaat taaaatatat     5460

tagtgagcag gagaaagcac agcatattat agcactgaat gatttataaa cctattccag     5520

ggtcataaaa tgtgtcaacg gcttttctat agtaaggaga ctaggttcag atggttaatc     5580

taagacaaat aaatgagata agccatacac ttttacatcc tccatgtcct gtcttttctc     5640

tgttcaaaat aggatgttga caatgcgtct ctggcacgtc ttgaccttga acgcaaagtg     5700

gaatctttgc aagaagagat tgcctttttg aagaaactcc acgaagaggt tagtggagtg     5760

actttcgggg aatgaatgag ggtaaggcag cccccacggt tggcagagct gaccgtctgt     5820

ctgttctttt tgcaggaaat ccaggagctg caggctcaga ttcaggaaca gcatgtccaa     5880

atcgatgtgg atgtttccaa gcctgacctc acggctgccc tgcgtgacgt acgtcagcaa     5940

tatgaaagtg tggctgccaa gaacctgcag gaggcagaag aatggtacaa atccaaggta     6000

ggaaacaaat cagtgcggct tcaaccaaag aaaagcattg tgttctcaaa accccatacc     6060

tgtgtgtgat tcctaaatat cctctagctc caatgcaaag ctggctttga cttcttgctc     6120

atattgtgtt tgccaccaca gcctccccac cactcacatc acctccttta tttatttatt     6180

tattttctta tttatttatg agacagagtc ttgctctact gcccaggctg gagtgcagtg     6240

gcaacatctt ggcacactgc aacctccgcc tcccaggttc aagtgattct cctgcctcag     6300

ccccctaaga gctggaacca caggcaagca ccaccatgcc cggctaattt ttgtattttt     6360

agtagagatg gggtttcacc atgttgacca ggcttctctc aaactcctga cctcaggtga     6420

tccaccctcc tcagcctccc aaaatgttgg gattacaggc atgcgccacc acgcctggcc     6480

acatcacctc cttcagaata gcagactctc ttccccctaa ccttgcctcc aagtaaaccc     6540

caatgccata cctttgacct ccactgtgtt gaaatgagca ctgtagagtg aactctgaaa     6600

atactaatgt cagtactcca ctgctctttc cctggctttc aaaacagaaa tttaaaccta     6660

tactggaaga cattcagtga gaaatatgat tttttttttc taagagagtc aaaagacttg     6720

aatgtgagca atctacattt ctgttttctt cccaacagtt tgctgacctc tctgaggctg     6780

ccaaccggaa caatgacgcc ctgcgccagg caaagcagga gtccactgag taccggagac     6840

aggtgcagtc cctcacctgt gaagtggatg cccttaaagg aaccgtgagt accaaccctg     6900

cagtaaaaga gggaaaataa tgacccattc tgctgactag gctcatgatg atacctgaac     6960

aaaatgttga gtgagtaaaa atgtatatca taatgcaaag aaaatgagtt atcaagacag     7020

actcaaaagg gacttcatgg aactcttgaa ggttttagct tgcctatatc attgcttcta     7080

atatgaagga cttggtactc gcattctcca cctaaaatta gagtggtcgc catttgccgc     7140

taatggaaat tattgcagaa ggtctgtaaa tggttctggg aacagctggg tttttctgag     7200

aaataacacc agacatcttt ctcaccccct gcagaatgag tccctggaac gccagatgcg     7260

tgaaatggaa gagaactttg ccgttgaagc tgctaactac caagacacta ttggccgcct     7320

gcaggatgag attcagaata tgaaggagga aatggctcgt caccttcgtg aataccaaga     7380

cctgctcaat gttaagatgg cccttgacat tgagattgcc acctacagga agctgctgga     7440

aggcgaggag agcaggtagg gaactcagac ttggatgcgt gaactaatgg tgaccatttg     7500

ttaggccctg tgccactggg ctctaagcag tgtcacattt aatctttaga aagtttcttt     7560

gaggtaactg ctttccactt tttgtagagg aggaatttga attgagagag agtaagtgac     7620

ttgctgaaaa agggttaatc aacagcagag ctgggatttg aacccataac tctgtcaaag     7680

cctccactcc taactcctgt tcatgctcct gtggagaaaa tgcttgtagt aacatatttt     7740

aaatgtacta acaagaccag tcatgggaaa atgtttctga gacaaatctc tagtttatga     7800

tttaaaacag tacgttttct tacgtgacga aaacaaaaag tgtgttaatt tgttcccagt     7860

ggttgaagtt atttgccaac aattttactg tttctcttca tctgtttata ggatttctct     7920

gcctcttcca aacttttcct ccctgaacct gaggggtaag cattttattt ccctttagga     7980

aaaacgtcag ctgcttgtaa ccactgtgtt tatgtcaaag cattcatttt ttttaggata     8040

tctgaaaaaa tgccatataa gagaaaactc tataaaacat ctataatttt cgaacccaag     8100

tacactcttg cattctatgc tttaagttaa atgcaaactc ctttttcctt cttcctgctg     8160

caagtactat ctcatcctga tgctcaagag tgtcagggcc tgggtttcca aacagagact     8220

accctaaaat tatttggcga gtagtacttt acacaattgc ctctccccca caaatcataa     8280

ttgtttcagt aaaatggtta cttggttttt ccaagaaaaa actcgttttt actcattttt     8340

ggcctgtttg tttatttaga aactaatctg gattcactcc ctctggttga tacccactca     8400

aaaaggacac ttctgattaa gacggttgaa actagagatg gacaggttgg tatcttttaa     8460

ggaaaaaata gggtaatctc agacaggagt tgatatattt taaaatcagt gaatctgaat     8520

ctcagataca gctggctaat ttgagaggtt caggtttcat tcatgcctac taaaaaaaga     8580

ataggcttct tcttccagca gtacacacag ccaactaatt atttggctcc tggatgtgaa     8640

gttgagatag cagtcttcct gtgctccaga attagtgatt tgctttggtg cttaatttga     8700

agtgggagta agcttcctta aaccacttcc taaagcagct acatgaaaca gcttcactag     8760

actacctcaa tatgaggaat gttttgatcc tggacatatg gtgtcttcct acctccatac     8820

tttatagatt cctaaaccca tctatataat acaagcatgt gccatacgat catttagttt     8880

cttattacct ccctatgcca ggaaagaaat agttgcaatt tattgtagtc atcatgaaat     8940

cttcccttgc acataaattt aaaatgtacc tgctgcacat tttaatatgt cttaattgct     9000

tttaaacttg gctgtattgt gtacaactat tataccatct tttataaaca cagtttttta     9060

agaaatttct ttttgtaagt tacaacattc cactggatcc ttatattgcc tgtagtggaa     9120

gagggtcttg tgtgtctgcc ccttctagtt ttcactcatg cagaagcaac ataaccttct     9180

gatttgcaca ataaattaca tatatttagc aggattttta tttgccgtga tatataggat     9240

aatttagtct ttggcatgtg gcattatatt tattttggtt ttttttttta aacaggttat     9300

caacgaaact tctcagcatc acgatgacct tgaataaaaa ttgcacacac tcagtgcagc     9360

aatatattac cagcaagaat aaaaaagaaa tccatatctt aaagaaacag ctttcaagtg     9420

cctttctgca gtttttcagg agcgcaagat agatttggaa taggaataag ctctagttct     9480

taacaaccga cactcctaca agatttagaa aaaagtttac aacataatct agtttacaga     9540

aaaatcttgt gctagaatac tttttaaaag gtattttgaa taccattaaa actgcttttt     9600

tttttccagc aagtatccaa ccaacttggt tctgcttcaa taaatctttg gaaaaactc      9659


<210>  2
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  3
<211>  8515
<212>  DNA
<213>  Mus musculus

<400>  3
ctctgccact cttgctccgg gaccccagag accccagcgc tcctacgatt cacagccacc       60

gcgccctcat tcccttgttg cagtttttcc agccgcagca agccagccca ccttcgaagc      120

catgtctacc aggtctgtgt cctcgtcctc ctaccgcagg atgttcggtg gctccggcac      180

atcgagccgg cccagctcca accggagcta tgtgaccacg tccacacgca cctacagtct      240

gggcagcgca ctgcgcccca gcactagccg cagcctctat tcctcatccc ccggtggcgc      300

ctatgtgacc cggtcctcgg cagtgcgcct gcggagcagc gtgccgggcg tgcggctgct      360

tcaagactcg gtggacttct cgctggccga cgccatcaac actgagttca agaacacccg      420

caccaacgag aaggtagaac tgcaggagct gaatgaccgc tttgccaact acatcgacaa      480

ggtgcgcttc ctcgagcagc agaacaaaat cctgctggct gagctcgagc agctcaaggg      540

ccagggcaag tcgcgcctgg gcgacctgta cgaggaggag atgcgggagc tgcgccggca      600

ggtggatcag ctcaccaacg acaaggcccg tgtcgaggtg gagcgggaca acctggccga      660

ggacatcatg cggctgcgag agaagtaagg cctgacctac gcgagtggtg gggtgtggga      720

gggaggggag tcctgggcct tgcactgggg ctgccacgcc cttggggatg tggctggggt      780

ggcggttgtc tggaggatag cagaggaagc gggccccacc ctgaacctaa actttgcagt      840

gaacatttct cttttcgcct cactcaagca cttccattga actttttaga aagtttctta      900

ggtccttctt ctgggcttac agttaccaga caggaggaaa gaatgggtgt gaagggttcc      960

agacaaagag atggcaaagg catctgggat attgggacag gggattggct gtaattgtaa     1020

gggaagggca gtgattgtct tttccagtgt gccccaactc cagctaacac ctgcagagag     1080

ctgccacctc gacaagttgc agtaactact gtgggtggag gtgtcacagc agctctggac     1140

tcaaggcttg gcggcatttg tggttgggtg tggccgcccc gcccctggcg gttttccagt     1200

tcccctttga ttaatgtgct gctgcttcag attgcaggag gagatgctcc agagagagga     1260

agccgaaagc accctgcagt cattcagaca ggtttgtaga cttctttttc acatgcagcc     1320

agcagcccaa tggagccaac ccgcgagcgg ttctaaaagt tacttccctt aggttttaaa     1380

aggtgcagaa cttcacgtct gcttgtaaag ccccctggcg gcggaaagcg cacagattga     1440

aaaactccac tatttagggc agtctttgga acatgaaggc tttattttct gcttcgtttc     1500

cagatttttc tgatccccca cacccccgaa acatttctcc tttcgttttt tgaaacatat     1560

cgacattcgg atattgaatg gttacaattt gattacattg tggattgtga aggtgaaatt     1620

ggctaacttt cacaaggtca taaaaaccac agttgcttcc tccagttgga aatgtagaat     1680

actctggagg atgagaaagt ttaactggaa ttaagccaag ttccctttct tccttcgaag     1740

ttcggcactg cgtgaaagtt agcagaagag tcattgcaca accatttttg aaatctaaca     1800

agggtgaaaa gaagccatct gttcccgtag ctcaagggtg ttaaaggttt ctatgggctt     1860

cactatggaa tgtagatagg gacgttctgg caaatgcggt ggctctggac agaaagaata     1920

ggggcctttg tgttcccaga gcagctttgc aacaggctac attcttattg aatatgtaat     1980

gatgtaacca cagttccaat tggacacaag tatttgctaa catccattat cttgtgtctg     2040

ggccaggctt gtgaggtatg ccgtgtacaa agttcttaaa gctaaagtcc tccctcacat     2100

ttggaaaggc ccccttttag gggggtttgt agactcatta gcaccctcca caaacaaaat     2160

taaaccctaa actgaagaat ggagtatttt atggagggag gatttgtttg tttgtgtttg     2220

ttccagggtt aggcattacc ttagcatccc gaagtggaca gatggccagt tcagtcttgt     2280

ttggaacact tgttaggatc aacagccaaa ctctccagat gaatgttcta aggtagcatt     2340

ctgaaggcat ttgcatcctt aatggcagta gacgaatatg cagccccttt cagtcactgg     2400

gcattttcag tcatcaccaa aggaatgttt tctacaaagc actgagttaa tacacaccat     2460

ctcttatttg tggactaaaa attgtttcat tcattcattt aaatgaaatg acacatttag     2520

ctgaactttt tcgagaaggt tagtccaata tcatttatat attttttgat ggcttagcag     2580

aagtcagaaa tgaatgatac tactatttaa gttcttatat tcttttttaa attagtattt     2640

tctttgggac tgatagagta actcaacatt atagttataa actatactgc aaatacagtt     2700

gcttacaagg gaagtttcca aacatttcct tgaaaggaaa caacatttca catgcaagat     2760

tgaacagtct gtcttaaaat agatcacttt ataaaaactc tgcagagaag tttaagtata     2820

gtttcattgt aagtgttttg atctgtcatc ctaaaacaga caaagtcatt gaaataacac     2880

tgtgacagct gggacaggca gaaataccct ataggctgag ccagggtgtt ttacacatta     2940

aaaaaattag agaaggcaaa acaatatagt tcaggattat atttcttttc cttcttgccc     3000

gaggagcata tctctgcaaa tgcaagacct ggattttgaa caatgaatta ctacttgata     3060

cgaggctagc ctgggaacct ggatgccaga taactgagtg cttattctaa attccaaaga     3120

taagcatctg aaggtttgaa tacaggaaac aaaaaagagc atgcatatat gttaaccctt     3180

ctgagctcaa ttttaaatga tttttaaaaa atatgtaatg tgtttgtgtc tgtgtgagtg     3240

tataggacat ttctgcaggc ttgcatgagg ccagaagagg gcacctgatg ccctggagtt     3300

ggaatcataa accttcatga actgctccat gtgggtgctg ggaaccaaac taaaatcctc     3360

tgaaagaaca gcattcttta ctactaagcc tcactttaga aaacatttta attttatttt     3420

tgaagctctc atttttatat tacgtgtact caagcaaaca tgaagttgga caatctcatc     3480

aactactatc atcacaaaat tacagactta ttaaatgtga cagaggttta aaactgaaaa     3540

tgaatttttc catatagttc accataccat gtcattgtgc atatacatgt gtttattttt     3600

aacttgtcta ctagttagct tcaatacaac caaatggttt cctattcatt tttaaagcta     3660

agaatgaata ttggaatgtg accctaaatg atttataaat ttatcaaggg tcatgaaatt     3720

ttcagcacct tttctacaat aaggagaatg ggtttacatg gttaattttt gaacaaataa     3780

ataaataaat aaataaataa ataaataaat aaataagggg ctgtagagac aggtcaatgg     3840

ttaaaagcac tggctactct tttagggcac ctggaattca atttgcagaa cccacagggc     3900

tgcccacact cttctccagt tccagggcat cttttgctct cttattgctt ttgtggatac     3960

cacatgctcg tggcatactt atatacatgc aggcaaaaca cctttataca caacataaag     4020

tgaaaaaggg attaatataa ataagttaga taaaggacag actttatcac cctccacatc     4080

atcttttctc ttttcgaaat aggatgttga caatgcttct ctggcacgtc ttgaccttga     4140

acggaaagtg gaatccttgc aggaagaaat tgcctttttg aagaaactgc acgatgaagt     4200

aagtgacacc aatttctgtg ggtgaacaaa gctgcgaccg tgtagtctac gacctctctg     4260

tgtctgttct ttctccagga gatccaggag ctgcaggccc agattcagga acagcatgtc     4320

cagatcgatg tggacgtttc caagcctgac ctcactgctg ccctgcgtga tgtgcgccag     4380

cagtatgaaa gcgtggctgc caagaacctc caggaggccg aggaatggta caagtccaag     4440

gtatgaaatg agccagagtg gcaagaacct ctagctctca gacacgtgcc tctaattcca     4500

ttagtaacct ccagctctac tcagaagctg gcttaaagct tggaccgcca ttgttgtttc     4560

acagcacccc ttccccctca tctccattca cagtttcctt tagtatggca gactcccttt     4620

ccactcattg tcttccctga cttcaaagaa taccttactc tcatgctctt gactgccacc     4680

acttggaaag cattgcagta gagcaaatac tgtttgaaaa cgcaatgctg gtgttctgct     4740

tctctttccc tggttttcca aaagacgttc agacaaattc taggaaacac acaggcagga     4800

tgaagatgcc tctttgttct aagtgagtga aaactcatgg aagtgaacaa tctctacttc     4860

ttttcttttc ttttcttttc ttttcttttc ttttcttttc ttttcttttc ttttctttct     4920

cctcctcctc ctccttctcc tcctcctcct cctcctcctc ttcttcttct tctacttctt     4980

cttcttcttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct tcttcttctt     5040

cttcttcttc ttcttcttcg actaagctca caaccaaaaa caacctctat ttctgattcc     5100

ttcttgacag tttgctgacc tctctgaggc tgccaaccgg aacaacgatg ccctgcgcca     5160

ggccaagcag gagtcaaacg agtaccggag acaggtgcag tcactcacct gtgaagtgga     5220

tgcccttaaa ggcactgtga gtactacagc agcaaagggg gggaaatacc gtgctcagta     5280

ctattctgct gactaggtta acaatgagac ctgtacaaat aaattaaaca cacacggaca     5340

cacacacaca cacttatcca aagagaatga attatcaaga tagttttaag gattatttaa     5400

tgagtacctt gaaagtctta gtttacatat gttattgatt gtaataagag gggttttaga     5460

ggttactcct gtaacctcat cactctggag aatgaggcag ggggattata aattcacagt     5520

taagctaggc tgcatgtaaa agtgttattt catcaaagca aaacatggaa ctgggtgctt     5580

gtgttctctg ttcaaagcta gtgggcacct accattaaaa gaattactgt accttattta     5640

tgaatatttt gggggacagc cgggttttct gggaaatcac atgagaagcc atttttgctt     5700

tctgcagaac gagtccctgg agcgccagat gcgtgagatg gaagagaatt ttgcccttga     5760

agctgctaac taccaggaca ctattggccg cctgcaggat gagatccaaa acatgaagga     5820

agagatggct cgtcaccttc gtgaatacca agatctgctc aatgttaaga tggccctgga     5880

cattgagatc gccacctaca ggaagctgct ggaaggcgag gagagcaggt atagaaggca     5940

aacgtgcatg tgtgaactaa ctcacagtcg tctttctagg aagatctcat ttaacccaga     6000

caccatatat atgaggaact taacgttgca gagagtaact tgctgtggtc agagataatt     6060

aatagcagag tagatttgaa ctcacagcca tgcaaaagac aatacgttct ccctctataa     6120

attcttctgg ttcatgtttc tgtgtggaaa aaaatatctt ccgaaattta aatgggccaa     6180

tgagaccaag catgggtaga aagttcttaa acaagtcact aacagcaata gattttcatt     6240

tggtggaaac aagaactgcg aaaacttgtt cctgcttctt gaagtgcttt gttctcaagt     6300

tttttgtgtg tttctttctc tttttatagg atttctctgc ctctgccaac cttttcttcc     6360

ctgaacctga gaggtaagta cattgtttca tcttatggga aaaaaatgtc acaaggctgt     6420

caccagtcac tctgcctgta gcatagcttc cacattttta aaaatatttt ttattacgta     6480

ttttcctcaa ttacatttcc aatgctatcc caaaagtccc ccataccctc ccccccactc     6540

ctctacccac ccactcccac agtaattctt gattgaactg tgcttttcca aagaaaattc     6600

aatgaaacat gatttctctt ttataaatac atgtgtatag ccattttatt ttctgaatat     6660

ttcttttggg cttctgaggt tctgatagag ttaagtcact ttctcgcttc cgtttcttct     6720

ctcgaaacct tccatgtact gccccctgac atatatggct gtcttttcag ttcatggctt     6780

ccttttgttt aaatgctgtt acacacacac acacacacac acacacacac acacacacac     6840

acactgtgta ttcttacata catgagtaca atggctcatt ctgtataata ttacttacat     6900

gtatgctttc aggctcgacc atctggtccc ttttttatta tagttctcat gactgctgga     6960

gaccaaaccc agggcaatca gctaagctaa acccacagag ctccacccct agcctgatac     7020

cctcagtttc aaactcgagt acattcttgc ctttgctacc ctgttaagta tagactcagt     7080

ctacttcctg ctaatggcaa agtcagtgaa ctactacctc agcctgaatg aaggagccct     7140

taggtgctgt gtactcaaat ggatagtgct atgtaggatt atgtatgagt agcactttaa     7200

ataaccataa aaataaagtc atgatgcttt gggtaaaatg gtaatgtttt aaactttttc     7260

ttatgttact gccttttttt tttttttttt tttttaattc agaaactaac ctggagtcac     7320

ttcctctggt tgacacccac tcaaaaagaa cactcctgat taagacggtt gagaccagag     7380

atggacaggt cagtattttt tagttaaaat atgggaaagt ttaaaagaag gaatgatgaa     7440

taaactatac aaccacttta aatatgtgtt ggtccccttt aagtcagcaa gcagatatat     7500

cagatatggc agctaactta aggagtcccc gtggatactg gatgaatagc ccccaattcc     7560

accaatgcaa gaaccaacag tctatttggt cttgattagg acagtaaact tcctgcacac     7620

catagtctgt gcactaaaca ggagtaaaac acccttaagg catctcttac attggctgca     7680

ttaaagtgtg tcacttaatg acatccgtga tatcagggat agtttgacat tggacataca     7740

gttctctctc agtgattgtc acctgcttat atagtacgag gacccatatg tggtcaatca     7800

ctttcttgtt gccactccat gccagggaag acatagttac aatgagttat aattataaaa     7860

gctcagcctt gcatgaggat ataaaataca tttgccatac ctctacatat gccttagttg     7920

cttttaagct ttgtttggaa ttgcaaaggc caacttccta aacacagttt caaagtattt     7980

tttgtcacac ctttccactg gatacttgta ttgtctgcag gaagaggcca ccctgcctat     8040

gcttctcctt agggcctcgt tctgcagagt cagcataaac tcccagtctg ctcaaccaat     8100

tctgtctgat tagggccata tctccttacc atgagttgat ttttgtttct tttttgagca     8160

ggtgatcaat gagacttctc agcatcacga tgaccttgaa taaaaattgc acacacttgg     8220

tgcaacagtg cagtaccagc aagaaggaaa aaaaaatcgt atcttaggaa aacagctttc     8280

aagtgccttt actgcagttt ttcaggagcg caagatagat ttggaataga aagaagctca     8340

gcacttaaca actgacaccc caaaagacgt agaaaaggtt tacaaaataa tctagtttac     8400

gaagaaatct tgtgctagaa tactttttaa agtatttttg aataccatta aaactgcttt     8460

tttccagtaa atatctgacc aacttgttac tgcttcaata aatcttcaaa aatac          8515


<210>  4
<211>  466
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Ser Gly Thr Ser Ser Arg Pro Ser Ser Asn Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ser Ser Ser Pro Gly Gly Ala Tyr Val Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Ser Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Asp Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Asn Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Leu Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Thr Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Glu Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  5
<211>  12566
<212>  DNA
<213>  Homo sapiens

<400>  5
gggcgggcag gtgggactcg gcccccctcc cacaaccccg ctcccgggca agctctcgag       60

ccgcgaggcc ggggcgggga ggggccgggc cgggggcggc ctggcaggaa gcggcgcgca      120

ccttccgccg ccggaggagc aggtggctgc cgtgcgggtc tgggccccag gcttcctgtg      180

tgcgcgctcg tcctctgctg tttcccgccg gagctcgttg ggcctccccg gcccgcccgg      240

cccatggccc agacccccga cggcatctcc tgtgagctcc gaggtaagcg ctggcccttc      300

ctgccttctt ggccgggagg aagtagtgca gccccaaaat cagaggccca cccagcgccc      360

cagagggcct ggtcagaggt cctccctgct ccccaggagg gcaggcgccc cagatcctct      420

cccctccttc ctcgctggcc gcagataagc cccagggccc cagcctggca cagactgtgg      480

gcaccagtgg cttctgtgca aggactgaag tcacccagca ggctgccctt ccacaggcga      540

gatcaccagg ttcctgtggc ccaaagaggt ggagctgctg ctgaaaacct ggctacccgg      600

ggagggtgct gtgcaaaacc atgtcctggt atggggcagg ggacagagcc ggggaggcgg      660

ctgtggcccc acagaaagag cctcttgctc tgcccaggat atcagactgt ctttccccag      720

gcactgctac gatggagagc ctacctgctg cacaccacct gcctcccgct gagggtgagt      780

cccagggcct ggccacaccc ccgcccgcca gcagctacct tggcaggggg ctgcatctgc      840

agagtggtcc ttcttggcct tgtgggccct gactttgcac cagcactggg ctctgggcag      900

ccgacaggag gggagtccag gcagatctgg ctctgcccca ggctgcccaa aggactggac      960

ttccatgagg gcggggctgg gggcttggtc ccagctgatc taggcccttt ctaggtggac     1020

tgcacgttca gctacctgga ggtccaggcc atggcgctgc aggagacacc ccctcaggtg     1080

agacacctag taccctacct gggcctgcag cctggtcttc atgctaccac catcacctgc     1140

gcccatgtgt ggagccgagg cctagtagtg ccccttccct aggtcacctt tgagctggag     1200

tccctgcgtg agctggtcct ggagtttcct ggtgtggccg ccctggaaca gctggcccag     1260

cacgtggctg cagccatcaa gaaggtcttc cctcgctcga cccttgggtg aggcctggca     1320

aattcgaggg gctggcaggg gaggagggag tgcatgagaa gggctgcttc ccatcccaga     1380

ggctggaagt cctttgcccc cttctcctta accccctacc aggaagctat tccggaggcc     1440

cacaccagcc tccatgctgg ctcggctgga gagaagcagc ccctcggagt ccactgaccc     1500

ctgcagcccc tgtggtaagg gtgaaggcag agccacaggc cttccagcct gccccacctc     1560

tgcctcccca gacccgcaag ctgggggggc cccaaactga acagagccat tcaggtccca     1620

gccaccacct agtctgtggg tctggtcttc ctccatcgct gatgttttgt ctctctcctt     1680

ttccacatcg cacccctatc ccctccccag gtggcttctt ggagacatac gaggctctgt     1740

gtgactacaa tggcttccct ttccgagagg agattcagtg ggtgagggta gggccctttt     1800

gaagggctct ggagacatct ggtcccccat gtgtgctgag cccctccctg ccccttgtgg     1860

ccccaggcga actgtaagca tctccttctc acccaggacg tggacaccat ttaccatcgc     1920

cagggctgcc gccatttcag cctgggagac ttcagccacc tcggcagtcg gtgtgtggcc     1980

tgccaggatg ggagaggagg aagatcccgg ggcccatatc cctgggcctc agtttctcca     2040

tggaggggct gctgggcctg ggacctggct ggagggccct gagctctgcc tctgttccca     2100

ccctcccacc agggacctgg ccttgagtgt ggctgccctg tcctacaacc tgtggttccg     2160

gtgcctctcc tgtgtggaca tgaagctggt gagggggttc ggggtaaggg cagggagggg     2220

ccaagggtgt gggccagggt gcagcccgct gagggccagg gtgcagcccg tgagccgccg     2280

ccctctgctt ctcagagcct tgaggtctca gaacagattc tgcacatgat gagtcagtca     2340

tcacacctgg aggagctggt gctggagacc tgcagcctga gggggtgagg gggacagggc     2400

agggcttgga gaggagagtc tggaggcttg ggactggggg ctagtggcct gggaggggtt     2460

ggcaaaccag gggcagaatc tcatgcctgg ggtctggtcc ccagagactt tgtccgacga     2520

ctggcccagg cgctggcggg acactcaagc tctgggctgc gggagctcag cctcgcgggg     2580

aacctgctgg atgaccgagg tatgactgag cctggggacc gcaggggtgg gcagcaggag     2640

gaggtgagac ccacgtggct gttcccaccc cccaaggcat gactgcactc agcagacacc     2700

tcgagcgttg tccaggagcc ctgaggagac tcagcctggc ccagacaggg ttgacaccgc     2760

gaggtaggct ggatgaggga gggggtgagg ggaggggggt gggggtctgt ccaactgctg     2820

agtgaccccg acccaccacc aggaatgagg gctctgggcc gggcactggc caccaatgcc     2880

gccttcgact ccaccctgac ccacctggac ctttctggga atcctggggc gctgggggcc     2940

tccgaggaca gtggggtgag tggctgtctt cagggtggga gcttggggtt gctcataagc     3000

cctgggtagg cgatccccca ctccatcgca cccctgtcct ccctccaggg cctctatagc     3060

ttcctgagcc gtcctaacgt actgtcgttc ctgaatctcg caggcaccga cactgccctg     3120

gacactgtga gggggtgctc cgtgggggga tggatgaccg gcagggcgga ctggagggcg     3180

ggacggggag ggctcggtcc ccccgcgggt gtagccaaca gcctcccccc gcagctcttc     3240

gcagcggtat cccgaggctg ctgcaccagc cttacccacc tcgacgcttc gaggaacgtc     3300

ttctcccgca cgtaaggggg acctgtcggg gccgggggag gctgctggaa gccgcctcct     3360

tgcggcccca ggcccacctt cccacttccc ccaggaagtc ccgcgccgcg ccggccgcgc     3420

tgcagctctt cctcagccgc gcgcggacgc tgcggcacct gggcctggcg ggctgcaagc     3480

tgccgcccga cgcgctcagg tcagtgtcgg accccggcca cgcccccgcg ggcgctccca     3540

ccctgccctg gccttcgccc ctccccgctc ctgcttctgt cgctcccaca acctccccca     3600

gatcctggcc ctgcctcctt cgttcgcacc ctggagcccc ctgtcccagc tcccgccacc     3660

ccgtgtaacg tcctctccca gagccctttt ggatggcctc gcgctcaaca cgcacctccg     3720

cgacctgcac ctggacctca gcgcttgcga ggtgagcgcc ggcccccaga agagaccaca     3780

cattgggaga ggcgctggga ggcggaaggg cagggccgtg ggccgcctgc ccctccccac     3840

tcgcggccta agtgggtccc acttcccacc tcccacctcc cacatacagc tgcgctcggc     3900

cggcgcccag gtgatacaag acttagtgtg cgacgcaggc gctgtgagct ccctggatct     3960

ggcggataac ggtgaggctg caggagagcc catcctcgca tcatccactc gattcccaat     4020

ccccacccta cccttgcaac ttcgcctcgt gcgtgacccg agtcaccccc aggcttcggc     4080

tcagacatgg tgactctggt gctggccatc gggagaagcc ggtccctgag acatgtggcg     4140

cttggaagga acttcaacgt ccggtgcaag tgagccccca ccctactcct gggcctccca     4200

gacaacaccc caccacccct gtcccccaca actgcggccc ctgcccacag ggagaccctg     4260

gacgacgtcc tgcaccggat tgtccagctc atgcaggacg acgattgtgt gagttcacgg     4320

gaccttgcag ggcctcgggc aattagacca ctttggtcct cctttctctt gttccctcag     4380

accctgtgac ctgccctcac tgacccctga ctccagccat caatggcttt ctcttaaccc     4440

cagcctcttc agtctctgtc ggtggctgag tctcggctga agctgggtgc cagcgtccta     4500

ctccgggccc tagccaccaa tcctaacctg accgcgctgg atatcagcgg caacgccatg     4560

ggggacgcgg gcgccaagtt gctggccaag gcgctgcggg tcaactcgag gctccggtgg     4620

gcggggtcag aggggtggga ccagcgggca gggggcgcgg tggagaggag ggcaccgggc     4680

taaggggagg gactgaatga ggcggagcaa atggagcagg ctgacgaggc gaatggacta     4740

ggccgagggt tgggtggggc gttgggaagc tccgtccccg actgaagcca ggcccggccc     4800

aggtctgtgg tctgggaccg gaaccacaca tctgctttgg gtctgctgga cgtggcgcag     4860

gcgctggagc agaaccacag cctgaaggcc atgcctctgc cactgaacga cgtggcccag     4920

gcgcagcgca gccgcccgga actgacagca cgtgcagtcc atcaggtggg cgtccccctc     4980

ttcccttgcc cttctctgca cggtaactcc gtccctcggc atttctcaat accccttgcc     5040

cctagatcca agcctgtctc ttgaggaaca accgcgcaga ccctgcctct tctgaccaca     5100

cgacccgcct tcagccactt ggtctggtct cagacccctc agagcaggtc aatgtcccct     5160

ccccaaccac gagaggtagg gcatgaggag acctgtggca tccgggagcc tccatgagtc     5220

agagggtctg actttcctgg ggccagggtg cctgagccct gctgtcccac acaaagtccc     5280

tctccttgat ctggaggcgg ctaaacaccc cttaaatagc tctccaaata acacccttgg     5340

ctgcctaacg ttaagcctgt aaacaggctg tcctgttaga gaggaatttt tatgtccttc     5400

ctcaattttc ccccaattgt agccccatct ctgtcctcac atatacgtga ctcccctccc     5460

ctctccattg tgtgcccaaa cccagctgct ccttcactgt cttcatctcc ctccactacc     5520

ttatctgttg gagatgtttc tacctctcca ttcccaaata cctcttcttt cctaagcttc     5580

agagcccaaa ggtcttaatc cagacatcct gctgggcttc atgctctgca cttctccaag     5640

tgatgtcatc gtcgctcaca aaccctgttg tctaccctgg agcccaatcc cactggtgcc     5700

cacagccacc cagtgctgtg gacagaggtt ggggcaccct tccaggtctc tcctggtcac     5760

actggagccc tcataggcct ccttcgtcct gcctctagac caaccttcat acatgccact     5820

ccttaccccc acaccaatta tcccttgctc ctcctggtcc ctcctccagg gctactcact     5880

cccttttcta cccctctctc agtctatcct ctgtgtggac agactgagct tctaaaacac     5940

agacatgatt tacaactcct ttccttccta ttctgggcac ttaggaagtg tatataaagt     6000

ccttaaaatg aaccaaagca acagatagtt ccttccctcc ttgaacagat agggttccaa     6060

agtggctggt ctaagggtgt cagcttcagg acctccctct gttaaagagc ctgggaggaa     6120

ggcaggcagg atctgggaga ctgggagggg gctaggctga gactgatccc catttcgccc     6180

caggaagtga atgaattgtg tcagtcggtg caggagcatg tggagctgct gggctgtggg     6240

gctgggcccc agggtgaagc cgctgtgcgc caggccgagg atgccatcca aaatgccaac     6300

ttctctctca gcgtgagcac tccccctcct gctacaagga cccttcccct cttagtcagg     6360

tgtcagctcg caactgcttt tcctctttgg ccctcagatt ctccccattc tatatgaagc     6420

tggaagctcc ccaagccatc actggcagct tgggcagaag ctggagggcc ttctgagaca     6480

ggtgggcgag gtctgccgcc aggacatcca ggtgagaggg tactcctgcc ccaaccccac     6540

ctccgtttgc aggtttgact cccatccttt agttttaact gtgatatccc ctgactcaat     6600

attctgttgg agttggagcc tcaagccagc agcctggtgt ctggccacat cctcaccatg     6660

ctctgactga cctttgtcta ggacttcact caggccacac tggacacagc aaggagcctc     6720

tgcccacaga tgctgcaggg atccagctgg agggagcagc tagagggggt cctggcaggc     6780

tcgaggggcc tcccggagct gctcccagag cagctgctgc aagatgcctt cactaggctc     6840

aggtaggctg gatggggctg ggctgggcaa ggctgagcaa agccagccca ttaacccctg     6900

tcctctcctg cccttaggga catgcggcta tcaatcacgg ggaccttggc agagagcatt     6960

gtggctcagg ctttggcagg cctgagtgca gcccgggatc agctggtgag ggggagatgt     7020

gcacacactt tcgtgcaaac acacacatgc agtgacttgg ccatctccct tgcaggggct     7080

ctgtaatgtc ttctggggtc atgtagccca gggctatttc agggtcccct tagttagcat     7140

caatgggatc atggctgagg ccctacctgc catctttggc tgcttggtat tgcaggtgga     7200

gagtctggct cagcaggcaa cagtgacaat gccccctgcc ctaccagcac cggatggagg     7260

tgagcccagc ctccttgagc ctggggaatt ggaaggtctt ttcttccccg aggagaagga     7320

agaggagaag gagaaggtaa gtggttttag aacacggggc atggcactcc cagtcttccc     7380

atcttgctgt ggagtgtgga aggtgaaagg cagctctttt gggttggtgc tctcctaccc     7440

caggctgagt ttgtgccctc cccaccagga tgacagtcct ccacagaaat ggcctgagct     7500

cagccacggt cttcacctgg tccccttcat tcacagtaag tcagggcctt gggggaggga     7560

gtttacgtgg gtgggctgaa gctccattag acttggggac ccggggacct ggatgaactc     7620

attcagcctt gtctgggtac ccaccagccc ttgactgggc caggtcgggc cccttgtgca     7680

acctgcaaag ctggggtctg ctgtggtcag cccggggcgg gacctgggcg gatctgggac     7740

aggacaccgg ctcagctcgc ctccccgcgc ccctttccct accccaggga cgcgcatgct     7800

gggcggcggc gcggagccgc gcgcgctcgg ggccgcgctc agcaccacgg acagcggcgg     7860

cggcggggga ggggcggagg ggcagagggg cggggggacg ggcggcgtag ccgggcccct     7920

ccccgcgccc tgggcgggtc ccccgccgcc ctagcgcctc cgccgccacc tccccgggct     7980

cggcgctcgg tgctcttctg gtgctgtccc ctcaggtgct gctgaggaag cggagccgga     8040

gcccgagctg gcggctccgg gagaagatgc agagccgcag gcggggccgt ccgcgcgcgg     8100

ctctccgagc cctgccgccc ctgggccccc ggccggcccg ctgccccgca tggacctgcc     8160

actggcgggg cagcccctgc gccatccgac ccgggcccgg ccgcggccgc gccgccagca     8220

ccaccaccgc ccgccgccgg ggggccccca ggtgagcacc cttcccccac tccggagcgc     8280

gtggaattgg ggatcacggg tggcccggcc gctcctcatg ggtggtagcg gtcaaggaga     8340

gggggtggtg ggggcccaag gccacctggt cgtgcggccg cggtcacatc ctggcttctt     8400

cctgaccacc ccccacccca ggccatgcct gtgcgggacc atgggtgtgc gggttccgtt     8460

cggggtgtgc ctgggtgtgg gactccgtct cggggcggcc cgcggcctcc gtggctgcgc     8520

gagagagggt gtccgtcctc cctccctccc ccggggctgc tgagagatgc cgggcagccg     8580

ggtagccgag ccgcggggcc aagcctgcgt ctgctgcgcg tccggcggcg gcgcgtgtgg     8640

ggagatgcgt gtgtgggctg caagcccgcg ggggcagcgg gcactggcgg agggcgggga     8700

ggagccggct tgaggccccc cagagggtct gacgcagcag ccggcgccac tgagccggca     8760

gcaggccggg tggagtgggg gtggggtggg ggacactgca gggaactgtt cggagcagag     8820

ctggtggcaa gtgggaacgg gtgaccccgg gggcacgtga gggctaggtt tgctggtgac     8880

cgggtggctc gggcgtgtag gatactctgt gggacaagga cgggtgtgga ctgggtgtgc     8940

gggagccagc agcgagtgag gagtgcgtga aatctggagt ctctgtccag cagcaggaca     9000

gtaggaggct ggtatcagca gcccctaggg tcaccccagt ctggaatcct ggagttattc     9060

agtccaggct gccggccggg gggggggggg ggtagaagcc agagttgcac tcaaccctga     9120

cccctgaccc catgatgccc cccaggtacc cccagccttg ccgcaggaag ggaatgggct     9180

cagtgcccgc gtggacgagg gcgtggagga attcttctcc aaaaggctga tccagcagga     9240

tcgcctgtga gtgaggggca tctgctgggg gtgggagagg gtgggatgcc tgatgggctt     9300

tctcgctcac tgctgggtgt ccccacagct gggcccccga ggaggacccg gccactgagg     9360

ggggcgccac tcctgtcccc cgtacactgc gaaagaagct gggcaccctc tttgccttca     9420

agaagcctcg ttcaacgcgg ggtccacgga ctgatctaga gaccagccct ggggcagctc     9480

cccgaacccg aaaaactaca tttggcgacc tactgcggcc gccaacccgt cccagccgtg     9540

gtgaggagct tggtggggct gagggggaca ccagcagccc tgaccctgcc ggcaggagcc     9600

gacctcgcta cacaagagat agcaaggcct actcgatgat actgctgcct gccgaggagg     9660

aggcaacgct gggtgccaga cccgacaagg tgaggcttgc tgatgggggg tggtgaaggc     9720

gcttctggga cccagggcgc ggactgtctc caactcgagc atctctgtcc ctagcggcgg     9780

cccctggagc ggggagaaac agaactggct ccatcctttg aacagcgggt acaagtaatg     9840

ctgcagagga taggcgtcag ccgaggcagc gggggtgccg aaggcaagag gaagcaagtg     9900

agttgagggg acctgagcat gaagtgagag ggcagatggc atgctgtggg tgacataagt     9960

gaccaagatg gaggagactc atgacagata ggtctaattg tcagttctac tccattctcc    10020

tcgaaatggt tacagattcg acctttcttc cctcttggct ttgacccagg cacaggccac    10080

cagcatctcc tctttggacc tgagaaagtc ttttctctgc aggtctaata gaaatctgag    10140

gcctgggcca ggcgccatgg ctcacgcctg taatcccgac actttgggag gctgaggcag    10200

gtggattacc tgaggtcagg agttaagaga ccaacctggc caacatggtg aaaccctgtc    10260

tctactaaaa atacaaaaat tagccgggtg tggcggtggg cacttgtagt cccagctact    10320

tgggagggtg aggcacgaga attgcttgaa cctgggagac aggttgcagt gagcctagat    10380

cgtgccacta cacactagcc tggacaacaa gagtgagact catctcaaaa aaagaaaaag    10440

aaaaaaatct gaccttgtca cttgtgcttg aaatagcaag tcctccaggg gcttcctctc    10500

aagacactgt tcagactcca caacctgctt cagagccctg tggggtcttg gccctggcca    10560

ccttaaaacc tcactgcttt cctcccctgg tgcaaatcag agcctccaca cacgtccctg    10620

ggtggtctgg atgtcctccc tgcctcgctt ccagtctcta attgtgggtt acgccaggtc    10680

cctcctcagc catccctgca gtgcccatgg ttcttccctg actctcctct gtgggccacc    10740

ctgctaatgt ctctctcatt agagtcccaa agaaccccag ccctccatac catccattca    10800

atatcttaaa aaacaaaaaa caaaaacaaa caaaaaacat gaagtcggcc tgaatttaga    10860

aatattcaag tgtgcaaaga gttctaagag ggctgtactg ggtttgccat gttcttgtcc    10920

agcccatggt gggcattcag tggcaggatt ataagaacaa gaacgaacaa aaggctaggg    10980

tgtggggagc gggcagggct ggaatctgat tgccctgttt cctgcagagc aaagatggcg    11040

agatcaagaa agctggctca gatggtaagt gggaccctgg ggtgtggcag tacatttgcc    11100

aggaggtgtc cttatagaca gcccccaagg cacttgctct ccttggggag gaaggggaga    11160

ggccaggttt ttcttcccct cacctccaag gtctggtacc tgagtcccca gctccgcctt    11220

gcaggtgaca ttatggacag ttccacggag gcccctccca tctcgatcaa gtcccgcacc    11280

cactctgtgt ctgctggtga gtgagggcca ctgtgtgtgt tggtagtggg agcagggaca    11340

ggcaggagtt gggtcagact gttgttcaga cctatcgcca atgcctgacc aggtcttggc    11400

tgacaccttt ctccctacag acccttcctg cagacctggc ccagggagcc aggggcctga    11460

gtctgccacc tggaagacac tggggcagca gttgaatgcg gagctcagga gccgtggttg    11520

gggccaacag gatggtccag gccctccctc ccctggtcaa agcccaagtc cctgcagaac    11580

cagcccctcc ccagacagcc tgggcctccc agaggaccct tgcttgggcc ccagaaatga    11640

aggtaggcag gcacctgatt ccccacccca atcctggcct cggggctgga ggagttcctg    11700

ctgggaactc agctcctcta aggaccctga gggtgggagg caagggctgg agtgggggca    11760

gctgttggaa tacccctgat tccctggcct ccctcagatg gccagctgag gccgaggcct    11820

ctctcggcag ggcggcgagc agtgtctgtg catgaggacc agctccaggc ccctgctggt    11880

gaggggagac acctccacgt gtgcttgaat gcaggagatg tgggagggtg ggcttctggg    11940

gctcccttca tagctttggt ccttggaggg agccaccagt gtgtgaggtc tcaagaaatc    12000

agggagccag aagaccaggt gcaagggttt gacagcaagc ccttccaact agcactggct    12060

ccacttcccg aagagcagcc tctgccaggg gtgaggacgc agggacgggg gatgctctga    12120

aggcagcagt gtgtgtgagt gcatgcttat gtgcactgga ggtggaagag aggggcaggg    12180

gatggacaga ccccaagcct tagcaaccca ccccaagcct ttctgtgtcc cttagaacgg    12240

cccctgaggc tgcagcgctc ccccgtcctc aaacgcaggc caaaactcga ggcacctcca    12300

tccccaagcc taggtaagag ggggtccagg ccagctggga gggtggcagg actgcttagc    12360

ccagccctga cccttcctct ctctccctcc ctcccctcac aggatctggc cttggaaccg    12420

agcctctgcc cccacagccc acagagccct ccagccctga gcggagccca ccctccccag    12480

ccacagacca aagaggcggc ggccccaatc cctgatcctc tcctctcctg ccgcatgaga    12540

ttattttatt aaaaaactca aaggaa                                         12566


<210>  6
<211>  1435
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gln Thr Pro Asp Gly Ile Ser Cys Glu Leu Arg Gly Glu Ile 
1               5                   10                  15      


Thr Arg Phe Leu Trp Pro Lys Glu Val Glu Leu Leu Leu Lys Thr Trp 
            20                  25                  30          


Leu Pro Gly Glu Gly Ala Val Gln Asn His Val Leu Ala Leu Leu Arg 
        35                  40                  45              


Trp Arg Ala Tyr Leu Leu His Thr Thr Cys Leu Pro Leu Arg Val Asp 
    50                  55                  60                  


Cys Thr Phe Ser Tyr Leu Glu Val Gln Ala Met Ala Leu Gln Glu Thr 
65                  70                  75                  80  


Pro Pro Gln Val Thr Phe Glu Leu Glu Ser Leu Arg Glu Leu Val Leu 
                85                  90                  95      


Glu Phe Pro Gly Val Ala Ala Leu Glu Gln Leu Ala Gln His Val Ala 
            100                 105                 110         


Ala Ala Ile Lys Lys Val Phe Pro Arg Ser Thr Leu Gly Lys Leu Phe 
        115                 120                 125             


Arg Arg Pro Thr Pro Ala Ser Met Leu Ala Arg Leu Glu Arg Ser Ser 
    130                 135                 140                 


Pro Ser Glu Ser Thr Asp Pro Cys Ser Pro Cys Gly Gly Phe Leu Glu 
145                 150                 155                 160 


Thr Tyr Glu Ala Leu Cys Asp Tyr Asn Gly Phe Pro Phe Arg Glu Glu 
                165                 170                 175     


Ile Gln Trp Asp Val Asp Thr Ile Tyr His Arg Gln Gly Cys Arg His 
            180                 185                 190         


Phe Ser Leu Gly Asp Phe Ser His Leu Gly Ser Arg Asp Leu Ala Leu 
        195                 200                 205             


Ser Val Ala Ala Leu Ser Tyr Asn Leu Trp Phe Arg Cys Leu Ser Cys 
    210                 215                 220                 


Val Asp Met Lys Leu Ser Leu Glu Val Ser Glu Gln Ile Leu His Met 
225                 230                 235                 240 


Met Ser Gln Ser Ser His Leu Glu Glu Leu Val Leu Glu Thr Cys Ser 
                245                 250                 255     


Leu Arg Gly Asp Phe Val Arg Arg Leu Ala Gln Ala Leu Ala Gly His 
            260                 265                 270         


Ser Ser Ser Gly Leu Arg Glu Leu Ser Leu Ala Gly Asn Leu Leu Asp 
        275                 280                 285             


Asp Arg Gly Met Thr Ala Leu Ser Arg His Leu Glu Arg Cys Pro Gly 
    290                 295                 300                 


Ala Leu Arg Arg Leu Ser Leu Ala Gln Thr Gly Leu Thr Pro Arg Gly 
305                 310                 315                 320 


Met Arg Ala Leu Gly Arg Ala Leu Ala Thr Asn Ala Ala Phe Asp Ser 
                325                 330                 335     


Thr Leu Thr His Leu Asp Leu Ser Gly Asn Pro Gly Ala Leu Gly Ala 
            340                 345                 350         


Ser Glu Asp Ser Gly Gly Leu Tyr Ser Phe Leu Ser Arg Pro Asn Val 
        355                 360                 365             


Leu Ser Phe Leu Asn Leu Ala Gly Thr Asp Thr Ala Leu Asp Thr Val 
    370                 375                 380                 


Arg Gly Cys Ser Val Gly Gly Trp Met Thr Gly Arg Ala Asp Trp Arg 
385                 390                 395                 400 


Ala Gly Arg Gly Gly Leu Gly Pro Pro Ala Gly Val Ala Asn Ser Leu 
                405                 410                 415     


Pro Pro Gln Leu Phe Ala Ala Val Ser Arg Gly Cys Cys Thr Ser Leu 
            420                 425                 430         


Thr His Leu Asp Ala Ser Arg Asn Val Phe Ser Arg Thr Lys Ser Arg 
        435                 440                 445             


Ala Ala Pro Ala Ala Leu Gln Leu Phe Leu Ser Arg Ala Arg Thr Leu 
    450                 455                 460                 


Arg His Leu Gly Leu Ala Gly Cys Lys Leu Pro Pro Asp Ala Leu Arg 
465                 470                 475                 480 


Ala Leu Leu Asp Gly Leu Ala Leu Asn Thr His Leu Arg Asp Leu His 
                485                 490                 495     


Leu Asp Leu Ser Ala Cys Glu Leu Arg Ser Ala Gly Ala Gln Val Ile 
            500                 505                 510         


Gln Asp Leu Val Cys Asp Ala Gly Ala Val Ser Ser Leu Asp Leu Ala 
        515                 520                 525             


Asp Asn Gly Phe Gly Ser Asp Met Val Thr Leu Val Leu Ala Ile Gly 
    530                 535                 540                 


Arg Ser Arg Ser Leu Arg His Val Ala Leu Gly Arg Asn Phe Asn Val 
545                 550                 555                 560 


Arg Cys Lys Glu Thr Leu Asp Asp Val Leu His Arg Ile Val Gln Leu 
                565                 570                 575     


Met Gln Asp Asp Asp Cys Pro Leu Gln Ser Leu Ser Val Ala Glu Ser 
            580                 585                 590         


Arg Leu Lys Leu Gly Ala Ser Val Leu Leu Arg Ala Leu Ala Thr Asn 
        595                 600                 605             


Pro Asn Leu Thr Ala Leu Asp Ile Ser Gly Asn Ala Met Gly Asp Ala 
    610                 615                 620                 


Gly Ala Lys Leu Leu Ala Lys Ala Leu Arg Val Asn Ser Arg Leu Arg 
625                 630                 635                 640 


Ser Val Val Trp Asp Arg Asn His Thr Ser Ala Leu Gly Leu Leu Asp 
                645                 650                 655     


Val Ala Gln Ala Leu Glu Gln Asn His Ser Leu Lys Ala Met Pro Leu 
            660                 665                 670         


Pro Leu Asn Asp Val Ala Gln Ala Gln Arg Ser Arg Pro Glu Leu Thr 
        675                 680                 685             


Ala Arg Ala Val His Gln Ile Gln Ala Cys Leu Leu Arg Asn Asn Arg 
    690                 695                 700                 


Ala Asp Pro Ala Ser Ser Asp His Thr Thr Arg Leu Gln Pro Leu Gly 
705                 710                 715                 720 


Leu Val Ser Asp Pro Ser Glu Gln Glu Val Asn Glu Leu Cys Gln Ser 
                725                 730                 735     


Val Gln Glu His Val Glu Leu Leu Gly Cys Gly Ala Gly Pro Gln Gly 
            740                 745                 750         


Glu Ala Ala Val Arg Gln Ala Glu Asp Ala Ile Gln Asn Ala Asn Phe 
        755                 760                 765             


Ser Leu Ser Ile Leu Pro Ile Leu Tyr Glu Ala Gly Ser Ser Pro Ser 
    770                 775                 780                 


His His Trp Gln Leu Gly Gln Lys Leu Glu Gly Leu Leu Arg Gln Val 
785                 790                 795                 800 


Gly Glu Val Cys Arg Gln Asp Ile Gln Asp Phe Thr Gln Ala Thr Leu 
                805                 810                 815     


Asp Thr Ala Arg Ser Leu Cys Pro Gln Met Leu Gln Gly Ser Ser Trp 
            820                 825                 830         


Arg Glu Gln Leu Glu Gly Val Leu Ala Gly Ser Arg Gly Leu Pro Glu 
        835                 840                 845             


Leu Leu Pro Glu Gln Leu Leu Gln Asp Ala Phe Thr Arg Leu Arg Asp 
    850                 855                 860                 


Met Arg Leu Ser Ile Thr Gly Thr Leu Ala Glu Ser Ile Val Ala Gln 
865                 870                 875                 880 


Ala Leu Ala Gly Leu Ser Ala Ala Arg Asp Gln Leu Val Glu Ser Leu 
                885                 890                 895     


Ala Gln Gln Ala Thr Val Thr Met Pro Pro Ala Leu Pro Ala Pro Asp 
            900                 905                 910         


Gly Gly Glu Pro Ser Leu Leu Glu Pro Gly Glu Leu Glu Gly Leu Phe 
        915                 920                 925             


Phe Pro Glu Glu Lys Glu Glu Glu Lys Glu Lys Asp Asp Ser Pro Pro 
    930                 935                 940                 


Gln Lys Trp Pro Glu Leu Ser His Gly Leu His Leu Val Pro Phe Ile 
945                 950                 955                 960 


His Ser Ala Ala Glu Glu Ala Glu Pro Glu Pro Glu Leu Ala Ala Pro 
                965                 970                 975     


Gly Glu Asp Ala Glu Pro Gln Ala Gly Pro Ser Ala Arg Gly Ser Pro 
            980                 985                 990         


Ser Pro Ala Ala Pro Gly Pro Pro  Ala Gly Pro Leu Pro  Arg Met Asp 
        995                 1000                 1005             


Leu Pro  Leu Ala Gly Gln Pro  Leu Arg His Pro Thr  Arg Ala Arg 
    1010                 1015                 1020             


Pro Arg  Pro Arg Arg Gln His  His His Arg Pro Pro  Pro Gly Gly 
    1025                 1030                 1035             


Pro Gln  Val Pro Pro Ala Leu  Pro Gln Glu Gly Asn  Gly Leu Ser 
    1040                 1045                 1050             


Ala Arg  Val Asp Glu Gly Val  Glu Glu Phe Phe Ser  Lys Arg Leu 
    1055                 1060                 1065             


Ile Gln  Gln Asp Arg Leu Trp  Ala Pro Glu Glu Asp  Pro Ala Thr 
    1070                 1075                 1080             


Glu Gly  Gly Ala Thr Pro Val  Pro Arg Thr Leu Arg  Lys Lys Leu 
    1085                 1090                 1095             


Gly Thr  Leu Phe Ala Phe Lys  Lys Pro Arg Ser Thr  Arg Gly Pro 
    1100                 1105                 1110             


Arg Thr  Asp Leu Glu Thr Ser  Pro Gly Ala Ala Pro  Arg Thr Arg 
    1115                 1120                 1125             


Lys Thr  Thr Phe Gly Asp Leu  Leu Arg Pro Pro Thr  Arg Pro Ser 
    1130                 1135                 1140             


Arg Gly  Glu Glu Leu Gly Gly  Ala Glu Gly Asp Thr  Ser Ser Pro 
    1145                 1150                 1155             


Asp Pro  Ala Gly Arg Ser Arg  Pro Arg Tyr Thr Arg  Asp Ser Lys 
    1160                 1165                 1170             


Ala Tyr  Ser Met Ile Leu Leu  Pro Ala Glu Glu Glu  Ala Thr Leu 
    1175                 1180                 1185             


Gly Ala  Arg Pro Asp Lys Arg  Arg Pro Leu Glu Arg  Gly Glu Thr 
    1190                 1195                 1200             


Glu Leu  Ala Pro Ser Phe Glu  Gln Arg Val Gln Val  Met Leu Gln 
    1205                 1210                 1215             


Arg Ile  Gly Val Ser Arg Gly  Ser Gly Gly Ala Glu  Gly Lys Arg 
    1220                 1225                 1230             


Lys Gln  Ser Lys Asp Gly Glu  Ile Lys Lys Ala Gly  Ser Asp Gly 
    1235                 1240                 1245             


Asp Ile  Met Asp Ser Ser Thr  Glu Ala Pro Pro Ile  Ser Ile Lys 
    1250                 1255                 1260             


Ser Arg  Thr His Ser Val Ser  Ala Asp Pro Ser Cys  Arg Pro Gly 
    1265                 1270                 1275             


Pro Gly  Ser Gln Gly Pro Glu  Ser Ala Thr Trp Lys  Thr Leu Gly 
    1280                 1285                 1290             


Gln Gln  Leu Asn Ala Glu Leu  Arg Ser Arg Gly Trp  Gly Gln Gln 
    1295                 1300                 1305             


Asp Gly  Pro Gly Pro Pro Ser  Pro Gly Gln Ser Pro  Ser Pro Cys 
    1310                 1315                 1320             


Arg Thr  Ser Pro Ser Pro Asp  Ser Leu Gly Leu Pro  Glu Asp Pro 
    1325                 1330                 1335             


Cys Leu  Gly Pro Arg Asn Glu  Asp Gly Gln Leu Arg  Pro Arg Pro 
    1340                 1345                 1350             


Leu Ser  Ala Gly Arg Arg Ala  Val Ser Val His Glu  Asp Gln Leu 
    1355                 1360                 1365             


Gln Ala  Pro Ala Glu Arg Pro  Leu Arg Leu Gln Arg  Ser Pro Val 
    1370                 1375                 1380             


Leu Lys  Arg Arg Pro Lys Leu  Glu Ala Pro Pro Ser  Pro Ser Leu 
    1385                 1390                 1395             


Gly Ser  Gly Leu Gly Thr Glu  Pro Leu Pro Pro Gln  Pro Thr Glu 
    1400                 1405                 1410             


Pro Ser  Ser Pro Glu Arg Ser  Pro Pro Ser Pro Ala  Thr Asp Gln 
    1415                 1420                 1425             


Arg Gly  Gly Gly Pro Asn Pro  
    1430                 1435 


<210>  7
<211>  12186
<212>  DNA
<213>  Mus musculus

<400>  7
ccgagtacgc ggaaggaaaa gtccctgagc gacagcaaca gtcaagattc gaccatcctc       60

ccacaacctc ccacccgggg cgaactcagc caacgaagcc ggggcgggga ggggccgggc      120

cgggggcggc ctggcaggaa gaagcgcgta ccttccgctg caggaggagc aggtggctgc      180

actgctgcct gggcccctgg cttcctgtgt acgctcctgc cggctgcttt ttcccgccag      240

agctcattgg gccgtcccgg ccctatggca cagaccccag acgacatatc ctgtgaactg      300

cgaggtaagc cctgggagcc cacctggcca tgaagagcct gactccaaac cagacctctc      360

ctctcggcgc cttagggaac ttgaccaggg gtttttgttc tggagggagg gccagtgcct      420

aaaagtccgc ttcatttctt cctagctgat ccacacatga atacctgggc actcagtcta      480

gcacagacct tgggcacaga gtggccctaa tagaggagcc aaagtcaccc agtagactgt      540

ctttccacag gcgagatcac caggttcctg tggcccaagg aggcggagct gctgttgaaa      600

acctggcttc cccaggaggg tgccgagcaa agccatatcc tggtatggta gccaggagtg      660

aagctcagga cagtggccag accctgcaca aagaaacttg atttccctag agtattagtc      720

ttttgtctcc ccccaggcac tgcttcgatg gagggcatat ttgctgcaca cctgccttcc      780

cctgagggtg agtcccaggc cgggccaaca ccccttcccc ttcagcaagg gactgccttg      840

cgcagctgtc ttctttgccc atgctggctt ttactttcca acagcagaca ggagggaagt      900

ctgggcaggt ctagctcagg atgccacaaa atcatgggct gtggagagag gacctgggtt      960

caattctccc accaccaggt gggctcacaa gtggttggaa ctctagttcg aaggcaccca     1020

ccaccgtctt ctggcatctt tgggaaccag gcacacaaga gtggtacaga gacaaacatg     1080

ccagcaaaca cccaatagta caatttttaa attttaagaa caagctagga ggtggtggtg     1140

cacgccttta gtcctggcac tagggagaca gaggcaggca ggcctggtct acagagtgag     1200

ctccaggaca gccaggtcta cacagagaaa ccctgtctca ggaaagagaa agaaagaaag     1260

aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aacgaactag gctcaagaga     1320

gtagcaacag tcagttggaa tgactctgat gctttccagg tggactgtac attcagctac     1380

ctggaggtcc aggccatggc actacaggaa acaccccctc gggtaagaaa gctggacccc     1440

aacttgaaca tacactccgc ttgatcattt attcctacac atatcactct gaatggacag     1500

cgcttccacc acacagggat ccaaaaggct cctccttccc caggtcacct ttgagctgga     1560

gtccctgcct gaactggtcc tggagtttcc ctgtgtggct gccctcgaac agctggctca     1620

gcatgtagct gctgccatca aaaaggtctt ccctcgctca acccttgggt gaggcttaga     1680

aaatccaagg ggtggggcag ggcctcagtg aaagcttttc atccttcaag gagctagaag     1740

tcccttttgc ctcttctcct tatcccctgc ctaggaagct attccggaag cccacaccct     1800

cgtctctgct ggctcgactg gagagaagcc atcccttaga gtccaccata cccagcagtc     1860

cgtgcggtga gggccaagtc agagccgcat aaaccttcca gtttgcctcc atgcaatcct     1920

agtctcttgg tattgggggg gctccccaaa gtgaacaggg ccacttttat cactgccgcc     1980

atctactatg gggctgacct tcccctgtct ctgacttagt gcctgtctgt ttccctatca     2040

ctcccccgac acctctctag gtggcttctt ggaaacatac gaagctctgt gcgattacaa     2100

tggcttccca ttccgagagg agattcagtg ggtgagggta gggccctttt gggggagttc     2160

tggggatgtt tgacgcccct tgtgtgtgct aagcccctct accctttgtg gccccaggct     2220

agctgtgact ttttttcttt acatctagga tgtggacact atctaccatc gccagggctg     2280

ccgccacttc tgccttggag atttcagcca ctttggcagc cggtatgagg ccagccagga     2340

ttgggaggcg agaactccag cacccaaatt cctagtctgt ctgtagaggg gggatgctga     2400

ctgagccctg tgtttggaag gccctgagca ctgcattttc tcttccccgc gatagagacc     2460

tggctttgag tgtagctgcc ttatcttata acctgtggtt ccggcgcctc tcctgcgagg     2520

acatgaagct ggtgagagag tacacacaaa agggagtgcc aagggtgtaa gggtcaaagt     2580

tcaacctgat gagtcacgac cctcttgctc tcagagcctg gaggtctcag aacagattct     2640

gcacatgacg agtcaatctt cctatttgga ggagctggtg ttggaggctt gtggtctgcg     2700

agggtgagag gcctgagctg ggcgtgggaa cctgtgatct gcggagagac tgggaatcag     2760

tcttaactgg ggtcttggtc ctcagagact tcgttaggcg actagcccag gccctggcag     2820

gacattttaa ttctggactt cgggagctca gcctgtctgg gaacttgctg gatgacagag     2880

gtatggcaga atctgggaga cccaaggcag ccgagccgga agaggtgagg ttcacagagc     2940

tgctctgtcc acaggtatgg ctgcactcag cagacaccta gagcattgtc caggagcctt     3000

gaggagactc agcctagcac agacaggctt gacacctcga ggtgggtggg actggggagg     3060

gttgggaggg ctcgaggtaa ggtgagcatg tcttgatact cagccgctcc tcccacccac     3120

caccaggaat gagagctcta ggcagggcac tggcaacgaa tgccaccttt gactctaccc     3180

tgacccacct ggatctttct gggaaccctg gggcactggg accctcacag gatagtgggg     3240

tgagtagcag tttttaaagt cagaaactgg gacggccgag tcagtgggat gccagatcct     3300

taggcaaccc ctgcctccct ctctccctcc gtagggcctg tatactttcc tgagccgtcc     3360

taacgtcctg gcgtatttga atcttgcagg cactgacgcc acgctaggca cggtaagagt     3420

gtggtcatgg gggatgcgtg gcagggcttg gctgcgcctg agcagggaag gaaggagagc     3480

ggagcgtggc agagaaagcc agggcttctg gaaggttatc gctaatacca ccttcctctc     3540

agctcttcac ggccttagct ggtggctgct gctccagcct cacccatctg gaagcttcaa     3600

ggaatatctt ctctcgcatg taaggggcac caggcaggct cggaaggacg aggcttgagg     3660

gtatcagctc ccctgagcgt aaatcccact tctgctctcc acccctcacc gcaggaagtc     3720

ccaagcggca ccagccgcgc tgcaacgctt ccttggcggt accaggatgc tacggcacct     3780

gggcctggcg ggctgcaagc tgccacctga agcgctcagg tcagtcctcc cgtgcagtca     3840

caaccttgag cagtgtctct tgacctctac tgcctcaccc ctctatgaca cccataatct     3900

ttcgtaaccc caacctgcct ggcgcttatt cgttcgcacc gagtcccgtg ttcccagatc     3960

ttgtcacctg tgtgttaccc ctctctcagg gcccttctag aaggtcttgc actcaacact     4020

cagatccatg atctgcacct agacctcagc gcgtgtgagg taggtacccg gtcctggttg     4080

tgagctgaga gcacgtccac attattgaga gtgaggctgg gaggccttcc ctacccaggc     4140

ataatcctga gtgcacccta cctccacctc cagctccgct ccgtgggtgc ccaggtgata     4200

caagacttgg tttgtgatgc gggtgccttg agttccttgg atctgtcgga taatggtgag     4260

gccgccaggg aacccatcca tccatgctcc tgttatttgt accagatccc cagggtgggc     4320

accctgacct ggtaggagtg atttgtgcat cactctggtt acccctaggc tttggctccg     4380

acatggtgac actggtgctt gccatcggga ggagccggtc tctgaaacac gtggcccttg     4440

gaaggaactt caacgttcgg tgcaagtgag tcccaagctt ccccctgtac ctctcaagaa     4500

ggactgcatc acccatttag ttccctaaca gcagcccctt tccacaggga gaccctggac     4560

gatgtcctgc atcggatagc ccagctaatg caggatgacg actgtgtgag ttcacagagc     4620

cctgtggggg gtcctcaagc aattaacgtc ttgtaatgct tcttatgtat attccttcaa     4680

accttctttg ctgaacctga gcccatgtat ccatcagtgc cttcctttta accccagcct     4740

ttgcagtcac tatccgtggc tgagtcgcgg ttgaagcagg gtgccagcat cctgatccgg     4800

gctttgggca ccaatcctaa actgacagcg ctggatatca gtggcaatgc cataggggat     4860

gctggggcca agatgctagc caaggctcta cgcgtcaaca ccaggctacg gtgggtatga     4920

tcatgataag ggctgggacc cgcaggagag ggcaagagtt atataataga cgggtgtatg     4980

ggtttaaggt atacatggtg atgagacagg tgattggata aggccagagg gttgggcggg     5040

gttctgcccc tgctgaagcc tggtggggcc caggtctgtg atctgggacc ggaacaacac     5100

atctgctctg ggcctgctgg atgtggcgca agccctggaa cagaaccaca gcctcaagtc     5160

catgccgctg ccactgaatg acgtaaccca ggctcatcgc agccggccag aactcacaac     5220

tcgagcggtc catcaggtgg gggtccgcgc ttctctctgc ccttttgtgt gtggtgactc     5280

caccccctgg cgtttctcac tatctctttg actgcagatc caagcctgtc tctggaggaa     5340

caaccaagta gactctactt cggacctcaa gccctgcctt cagcccttag gtctgatttc     5400

agaccactca gagcaggtta gtgccccttg ccctaatctt gaatacctga gcacctgagt     5460

cagagtctga cttttctgag ccacagtgct gagttctatg tctcaaacaa tttccttttc     5520

ttggtcaccg ttcttgaaac agcttcccgt gtaacatttg gctgctttaa gggtttaaat     5580

aggctgtcct tgctgtagcc tctttattcg acttcctatt taagggctaa cctctcttta     5640

ctgactgtgt ggctagctcc agcagtccta tctctggctt taatttcctt tcattaaccc     5700

atctttttgt attattctta cctctgcatt cccaagcctc aattcttttg tttggttttg     5760

gtttcttgag acagggtttc tctgtgtagc ctgggatatc cttgaactcc cagagatctg     5820

cttgcttctg cctcccaagt gctaggatta aaggcatgtg ccaacactgc ccagcccaag     5880

ccttgattga ttgattgatt gattgattga ttgatttgag acagggtttc tctgtgtaat     5940

ccttgccgtc ttggaattca ctctgtagac caagctggcc tcgaactcag aaatccgcct     6000

gcctctgcct cccaagtgct gggattaaag gcgtgcgcca ccatacacac acacatacac     6060

acaactgttc tctgtatgga tggttaaggt gacatctttg aaatcagagt gaccaaagct     6120

tctttccttc ctgttttagg cctggagaaa ataatcaagt gatcagatag ggtttccctc     6180

acagtttgtc ttcctgtagg aaaaccttgg aagggagaca ggcagaatcg gggagactga     6240

tgagaaacaa agggaggact aatccatgac tccctcctgc ctgcccccca ggaggtgaac     6300

gagctatgcc agtcagtaca ggagcatatg gagctgctgg gctgtggggc tgggccccag     6360

ggtgaggttg ccgtgcacca ggctgaggac gccatccaga atgccaactt ctctctcagt     6420

gtaagcaccc tctttcctgc tctgaggacc tttccgctcc caatcatgtg ccagtttgca     6480

agtccttttg ttccttggcc tccccagatc ctccccattc tctatgaggc tgggagatcc     6540

ccaagccacc actggcagct gcagcagaag ctagagagcc tcctgggtca ggtgggcgag     6600

atctgccgcc aggacatcca ggtaagatac tagtcctgcc ccagccgcac ctccccatgc     6660

aggcttgacc ctcattccac acgcttgtct gggataggcc cttagtcagc agtggtttaa     6720

tgggaactca caccttcaaa gccaaagggg ctgggttttg gcatactgct aacattttgt     6780

aacctttgcc caggacttca ctcagaccac cctggatacc acaaggagcc tctgcccaca     6840

gatgttgcag acacctggct ggaggaagca gctagaggga gttctggtgg gctccggggg     6900

cctcccagag ctgcttccgg aacatctgct gcaagatgcc ttctctaggc tgaggtgagc     6960

aagcccaact gggctgggca atgctggaca gagacagcac actaatcctc actgtctcct     7020

gcctttaggg acatgcgcct gtcaatcact gggaccctag cagagagcat tgtggctcag     7080

gctcttgcag gtcttcatgc agcccgagat cgactggtga gggggaagct ttgaacacat     7140

ttcatagagt aacttgttta accctcacgg gcaaccctga aatgacttct ggggtcataa     7200

gctagctact tagttctgcc tatctttggg tggcctggta ttacaggtgg agaggctaac     7260

tcagcaggca ccagtgacca tggcccctgc tgtaccacca ctgggtggaa atgagctcag     7320

cccccttgag actgggggat tggaagagct tttctttccc acggagaagg aagaggagag     7380

agaaaaggtg agtgtcttca gaatttcaag cctaggaccc cggctggctt tctccttctt     7440

gctctggaat gtagaaggtg aggagcaggt ctgggtcatc ctaaccctag actgaggctg     7500

tacccatccc accaggatga gagttcttca tggaaatggc ttgagcctag taactgtttt     7560

cacctggtct cctcccttca tggtaagtca ggccctggag taagagagtt taatccaagt     7620

ggactgaagc tctgttaaat ctggacactc tttcagccct gtcccgggtg taccctagcc     7680

cttccccgag ccaagccagg aagaaagcca gagtcagctg ttctcagaac cctgtgggac     7740

cagaacagaa taacactaag acacctcctt ccctacctcc tcctcccctt tccctaaccc     7800

caggacgcgc atgcttggcg gctgcacaaa gtcgcgcgca ctcggggccg cgctcagcac     7860

cacggacagc ggcgactggg ggaggggcgg gcggcgtagc cgggcccctc cccgcgccct     7920

gggcgggtcc ccgccgccct ccctagctcc tccgccacct ccccgggttc gacgctctgt     7980

gctcttctgg tgcttttgcc tcaggtgctg ctgaggaagc ggaacgggac cccgagctgg     8040

cagctccggg ggaagatgca gagccgcagg ctgggccgtc tgcacgcggc tctccaagcc     8100

ccgccgcccc ggggccaccc gccggccctc tgcctcgcat ggacctgcca cccgccgggc     8160

aacccctacg ccacccaacc cgagcccgac cgagaccacg tcgccagcac caccaccgcc     8220

cgccgccggg gggcccccag gtaagtgctt cccttccccc tcgcccctct tgagggtcat     8280

gggtggacca ttcactcttc acttgagata gaagactgga agatgggttg tggaggccca     8340

aggccaccgg atcgcgctct atcatctttc tggccaccct catactcagg ccatggcaat     8400

aacgggccat ggtgtgtggc tttcctgtga ggagctacta gatggtggac cccctccttg     8460

tagtggtctg ctctatgggt gaacatgcga gagcggatgt ccgccttgcc ctccctctcc     8520

taaggttgct gaaaaacact gggcagctgg accgcgggac actcctgcgt ctgctgtgta     8580

ccagcgggtg gatgtatgtg tgggttgggt actggcaagg gtagtgggca ctggcagaag     8640

gagaggagca gctggcctga ggccccctga gggtctgacg cagcagcggc gccactgagc     8700

cgggatgaga ggccgggtgg tgtggtgtgg aggtggaagg ttagggtact gcagggaact     8760

gttgggagta gaagggatgg catatttgca atgtgcgacc cataggtgtt tgcttagtga     8820

cagccaggtg gttcagggta tagcagcctc tggactgggt gggtgcgctg tgacagcaat     8880

gaagaatgaa agccagagtg gtacagacag tctccagctc cgggatgtac tcaggccagg     8940

ccactgggaa ggagaggatg tctaggaaga gtcacagttc ccagtcctga ctcctaacct     9000

cccaatgtct cccaggtgcc cccagccctg cttcaagaag gaaatgggct cactgctcgc     9060

gtggatgagg gtgtggagga gttcttctcc aaaaggctga tccagcagga tcacttgtga     9120

gtgagggtcg gttgactggg ggcggaggag ggtggaacat ccccgagttt cttcactcac     9180

tgatggttat tcctacagct gggccccaga ggaggatcca gccactgagg gtggtgccac     9240

tcctgtcccc cgcacacttc gaaagaagct gggtacgctc tttgccttta agaaacctcg     9300

ttcaacaagg ggtccgcgac ctgacctgga gaccagccct ggagcagcag ctcgagccag     9360

aaaatccaca cttggggatc tcctgcgacc accggcccgt ccaggccgtg gtgaggaacc     9420

tggaggggcg gaaggcggca ccagcagccc tgaccctgct cgcagaaatc ggcctcggta     9480

cacgcgggaa agcaaggcct actccatgat cctgctacct gctgaggagg aagcagccgt     9540

gggtaccaga cctgataagg taaggccagg ggccggggct gaggctcctc aggaacagag     9600

agcagtgggg ttctctcacc acttaggcat ctctgtcctc agaggcggcc tctggaacgg     9660

ggagacacag aactggctcc atcttttgag cagcgggtac aagtgatgct acagaggatc     9720

ggcgtgagcc gggccagtgg gggtgccgag agcaagagga agcaagtgag ttgggggtga     9780

actgcggggg caggtggcat gtggtaatct gtgggtgaca tatgtgacca agaagggaga     9840

aacacatggt gggaatagat ctaattatca gttacatgtt ctcatccctc aagaggcaag     9900

gaggagaact ttcttccttc ttgcttctga cctggttcag atcttctagg gtatagggaa     9960

ctcctttttc tgaagaagaa attaacagaa atttgacctt gttttacctg aaagttctcc    10020

aggaacttcc ttatccagat gccttatgtt ttttttttgt tttaatattt atgtgagtac    10080

actgtccctg ccttctgtct tcagacacac cagaaactag cattggatcc cattacagat    10140

agttgccggg agttgaactt gggtcctctg gaagagtagt cagtgctctt agctgctgag    10200

ccgtctctcc agtcccttta tccagattcc taatcccgct gtgagatctc acaggacctt    10260

ggtactggcc accttagacc tgttttcctt tgaagcctca cttggccatt gatttttatt    10320

ctctgactgt cgggtcatgt actggattat acaggctcct ttccagcctt ccctgacacc    10380

cttccatggt cacccggata acattactac aatcatggtc tttattagga actacacctc    10440

tgtatgccat ccatttaaat agctttccag gaagaacaca tgcagtgaga cctggcctga    10500

atgtagtgat gttaaagtgt ggcaagtcat agaactaatt atctgctgga tgtggcggta    10560

atctcagcat tcagaaaact ggggcaggag gattgcaagt aagactagcc tgagttgtct    10620

acagcaagac tatctcaaaa gcaaagtcta cctgtcatga ccaacatgaa catttttgca    10680

tgttagctat ctgtctatcc cagactgtaa ggtcagaggg tggaaactgg ctttaccatg    10740

ctctggccag cctatgctat gcattctgta gctgggtttt aacaacatgg acagagacaa    10800

ggctagggtc agggcggcag ggctgctgcc tgactcatgt gtttcctaca gagtaaagac    10860

ggcgagatca agaaggcagg ctctgatggt gagtaggacc ccacccggga caaggagata    10920

tatgttgggg aacaaggtgg cctcagataa cccctaaggc tccctccctc caccactaag    10980

gtctgacacc taagcctcta atccttcctt gcaggtgaca ttatggacag ttccacagag    11040

acccctccca tctcaatcaa gtcccgtacc cactctgtgt ctgctggtga gtgagggcca    11100

ctggatatgt taaaggaggt gcaagggttg ggaggggatc ggactgttgc tcagaaccat    11160

tccacagaca ggcttgggtg ttagctgaca ttgtcttctc tacccagatc cctcatgcag    11220

acctgggcca ggaggccagg ggcctgagtc tgccacctgg aagacattgg gacagcagct    11280

gaatgcagag ctcagaggcc gtggttgggg ccaacaggat ggtccagggc ccccctcccc    11340

atgtcccagc ccaagtcccc gaagaaccag ccccgcccca gacatcctga gtctcccaga    11400

ggacccctgc ttgggcccta ggaatgaagg taggtaggca ccccactcct aggctaggaa    11460

cccgactcat ctgggaaggc caaaggtggg aggcgaaggc tgggtgtggg cggagtatgg    11520

gaacgtcctc tgacatctcg gcctcctcta gatggccagc tgaggccgag gcctctttcg    11580

gcaggccggc gagcagtgtc tgtgcatgag gaccagctcc aggcccccgc gggtgaggga    11640

gacccctctg cctgtgcttg agtgcaggag aaagggggag gtgggctcga tcggtcttgg    11700

tccttggaca gcgccacctc ctgaaggccc acctcagcta gggtgggagg acacttgctg    11760

gacaatctat gggcgtagca tgtgcatggt tttgcgtgca ctcaaggtgg accagagggt    11820

tggggacagc cagtgagttt tttctgtatc ctttttagaa cggcccctcc ggctgcagcg    11880

ctcccctgtc ctcaagcgta ggccgaagct cgaggcaccc ccatccccaa gcttaggtga    11940

gagtgggcac gggccagctg ggatgctgat acgactgctc agtacaagcc tagcattgtt    12000

tctctccata acccttcaca ggctctggcc ttggatccaa gcctcttcct ccgtacccca    12060

cagaaccctc cagccctgag cggagccctc cctccccagc cacagaccaa agaggcggcg    12120

gccccaaccc ctgaatctct ctcctcctgc cgcatgaaat tattttatta aaaaacttga    12180

atgaaa                                                               12186


<210>  8
<211>  1295
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Gln Thr Pro Asp Asp Ile Ser Cys Glu Leu Arg Gly Glu Ile 
1               5                   10                  15      


Thr Arg Phe Leu Trp Pro Lys Glu Ala Glu Leu Leu Leu Lys Thr Trp 
            20                  25                  30          


Leu Pro Gln Glu Gly Ala Glu Gln Ser His Ile Leu Ala Leu Leu Arg 
        35                  40                  45              


Trp Arg Ala Tyr Leu Leu His Thr Cys Leu Pro Leu Arg Val Asp Cys 
    50                  55                  60                  


Thr Phe Ser Tyr Leu Glu Val Gln Ala Met Ala Leu Gln Glu Thr Pro 
65                  70                  75                  80  


Pro Arg Val Thr Phe Glu Leu Glu Ser Leu Pro Glu Leu Val Leu Glu 
                85                  90                  95      


Phe Pro Cys Val Ala Ala Leu Glu Gln Leu Ala Gln His Val Ala Ala 
            100                 105                 110         


Ala Ile Lys Lys Val Phe Pro Arg Ser Thr Leu Gly Lys Leu Phe Arg 
        115                 120                 125             


Lys Pro Thr Pro Ser Ser Leu Leu Ala Arg Leu Glu Arg Ser His Pro 
    130                 135                 140                 


Leu Glu Ser Thr Ile Pro Ser Ser Pro Cys Gly Gly Phe Leu Glu Thr 
145                 150                 155                 160 


Tyr Glu Ala Leu Cys Asp Tyr Asn Gly Phe Pro Phe Arg Glu Glu Ile 
                165                 170                 175     


Gln Trp Asp Val Asp Thr Ile Tyr His Arg Gln Gly Cys Arg His Phe 
            180                 185                 190         


Cys Leu Gly Asp Phe Ser His Phe Gly Ser Arg Asp Leu Ala Leu Ser 
        195                 200                 205             


Val Ala Ala Leu Ser Tyr Asn Leu Trp Phe Arg Arg Leu Ser Cys Glu 
    210                 215                 220                 


Asp Met Lys Leu Ser Leu Glu Val Ser Glu Gln Ile Leu His Met Thr 
225                 230                 235                 240 


Ser Gln Ser Ser Tyr Leu Glu Glu Leu Val Leu Glu Ala Cys Gly Leu 
                245                 250                 255     


Arg Gly Asp Phe Val Arg Arg Leu Ala Gln Ala Leu Ala Gly His Phe 
            260                 265                 270         


Asn Ser Gly Leu Arg Glu Leu Ser Leu Ser Gly Asn Leu Leu Asp Asp 
        275                 280                 285             


Arg Gly Met Arg Ala Leu Gly Arg Ala Leu Ala Thr Asn Ala Thr Phe 
    290                 295                 300                 


Asp Ser Thr Leu Thr His Leu Asp Leu Ser Gly Asn Pro Gly Ala Leu 
305                 310                 315                 320 


Gly Pro Ser Gln Asp Ser Gly Gly Leu Tyr Thr Phe Leu Ser Arg Pro 
                325                 330                 335     


Asn Val Leu Ala Tyr Leu Asn Leu Ala Gly Thr Asp Ala Thr Leu Gly 
            340                 345                 350         


Thr Leu Phe Thr Ala Leu Ala Gly Gly Cys Cys Ser Ser Leu Thr His 
        355                 360                 365             


Leu Glu Ala Ser Arg Asn Ile Phe Ser Arg Met Lys Ser Gln Ala Ala 
    370                 375                 380                 


Pro Ala Ala Leu Gln Arg Phe Leu Gly Gly Thr Arg Met Leu Arg His 
385                 390                 395                 400 


Leu Gly Leu Ala Gly Cys Lys Leu Pro Pro Glu Ala Leu Arg Ala Leu 
                405                 410                 415     


Leu Glu Gly Leu Ala Leu Asn Thr Gln Ile His Asp Leu His Leu Asp 
            420                 425                 430         


Leu Ser Ala Cys Glu Leu Arg Ser Val Gly Ala Gln Val Ile Gln Asp 
        435                 440                 445             


Leu Val Cys Asp Ala Gly Ala Leu Ser Ser Leu Asp Leu Ser Asp Asn 
    450                 455                 460                 


Gly Phe Gly Ser Asp Met Val Thr Leu Val Leu Ala Ile Gly Arg Ser 
465                 470                 475                 480 


Arg Ser Leu Lys His Val Ala Leu Gly Arg Asn Phe Asn Val Arg Cys 
                485                 490                 495     


Lys Glu Thr Leu Asp Asp Val Leu His Arg Ile Ala Gln Leu Met Gln 
            500                 505                 510         


Asp Asp Asp Cys Pro Leu Gln Ser Leu Ser Val Ala Glu Ser Arg Leu 
        515                 520                 525             


Lys Gln Gly Ala Ser Ile Leu Ile Arg Ala Leu Gly Thr Asn Pro Lys 
    530                 535                 540                 


Leu Thr Ala Leu Asp Ile Ser Gly Asn Ala Ile Gly Asp Ala Gly Ala 
545                 550                 555                 560 


Lys Met Leu Ala Lys Ala Leu Arg Val Asn Thr Arg Leu Arg Ser Val 
                565                 570                 575     


Ile Trp Asp Arg Asn Asn Thr Ser Ala Leu Gly Leu Leu Asp Val Ala 
            580                 585                 590         


Gln Ala Leu Glu Gln Asn His Ser Leu Lys Ser Met Pro Leu Pro Leu 
        595                 600                 605             


Asn Asp Val Thr Gln Ala His Arg Ser Arg Pro Glu Leu Thr Thr Arg 
    610                 615                 620                 


Ala Val His Gln Ile Gln Ala Cys Leu Trp Arg Asn Asn Gln Val Asp 
625                 630                 635                 640 


Ser Thr Ser Asp Leu Lys Pro Cys Leu Gln Pro Leu Gly Leu Ile Ser 
                645                 650                 655     


Asp His Ser Glu Gln Glu Val Asn Glu Leu Cys Gln Ser Val Gln Glu 
            660                 665                 670         


His Met Glu Leu Leu Gly Cys Gly Ala Gly Pro Gln Gly Glu Val Ala 
        675                 680                 685             


Val His Gln Ala Glu Asp Ala Ile Gln Asn Ala Asn Phe Ser Leu Ser 
    690                 695                 700                 


Ile Leu Pro Ile Leu Tyr Glu Ala Gly Arg Ser Pro Ser His His Trp 
705                 710                 715                 720 


Gln Leu Gln Gln Lys Leu Glu Ser Leu Leu Gly Gln Val Gly Glu Ile 
                725                 730                 735     


Cys Arg Gln Asp Ile Gln Asp Phe Thr Gln Thr Thr Leu Asp Thr Thr 
            740                 745                 750         


Arg Ser Leu Cys Pro Gln Met Leu Gln Thr Pro Gly Trp Arg Lys Gln 
        755                 760                 765             


Leu Glu Gly Val Leu Val Gly Ser Gly Gly Leu Pro Glu Leu Leu Pro 
    770                 775                 780                 


Glu His Leu Leu Gln Asp Ala Phe Ser Arg Leu Arg Asp Met Arg Leu 
785                 790                 795                 800 


Ser Ile Thr Gly Thr Leu Ala Glu Ser Ile Val Ala Gln Ala Leu Ala 
                805                 810                 815     


Gly Leu His Ala Ala Arg Asp Arg Leu Val Glu Arg Leu Thr Gln Gln 
            820                 825                 830         


Ala Pro Val Thr Met Ala Pro Ala Val Pro Pro Leu Gly Gly Asn Glu 
        835                 840                 845             


Leu Ser Pro Leu Glu Thr Gly Gly Leu Glu Glu Leu Phe Phe Pro Thr 
    850                 855                 860                 


Glu Lys Glu Glu Glu Arg Glu Lys Val Leu Leu Arg Lys Arg Asn Gly 
865                 870                 875                 880 


Thr Pro Ser Trp Gln Leu Arg Gly Lys Met Gln Ser Arg Arg Leu Gly 
                885                 890                 895     


Arg Leu His Ala Val Ala Glu Lys His Trp Ala Ala Gly Pro Arg Asp 
            900                 905                 910         


Thr Pro Ala Ser Ala Val Tyr Gln Arg Val Asp Val Cys Val Gly Trp 
        915                 920                 925             


Val Pro Pro Ala Leu Leu Gln Glu Gly Asn Gly Leu Thr Ala Arg Val 
    930                 935                 940                 


Asp Glu Gly Val Glu Glu Phe Phe Ser Lys Arg Leu Ile Gln Gln His 
945                 950                 955                 960 


Phe Trp Ala Pro Glu Glu Asp Pro Ala Thr Glu Gly Gly Ala Thr Pro 
                965                 970                 975     


Val Pro Arg Thr Leu Arg Lys Lys Leu Gly Thr Leu Phe Ala Phe Lys 
            980                 985                 990         


Lys Pro Arg Ser Thr Arg Gly Pro  Arg Pro Asp Leu Glu  Thr Ser Pro 
        995                 1000                 1005             


Gly Ala  Ala Ala Arg Ala Arg  Lys Ser Thr Leu Gly  Asp Leu Leu 
    1010                 1015                 1020             


Arg Pro  Pro Ala Arg Pro Gly  Arg Gly Glu Glu Pro  Gly Gly Ala 
    1025                 1030                 1035             


Glu Gly  Gly Thr Ser Ser Pro  Asp Pro Ala Arg Arg  Asn Arg Pro 
    1040                 1045                 1050             


Arg Tyr  Thr Arg Glu Ser Lys  Ala Tyr Ser Met Ile  Leu Leu Pro 
    1055                 1060                 1065             


Ala Glu  Glu Glu Ala Ala Val  Gly Thr Arg Pro Asp  Lys Arg Arg 
    1070                 1075                 1080             


Pro Leu  Glu Arg Gly Asp Thr  Glu Leu Ala Pro Ser  Phe Glu Gln 
    1085                 1090                 1095             


Arg Val  Gln Val Met Leu Gln  Arg Ile Gly Val Ser  Arg Ala Ser 
    1100                 1105                 1110             


Gly Gly  Ala Glu Ser Lys Arg  Lys Gln Ser Lys Asp  Gly Glu Ile 
    1115                 1120                 1125             


Lys Lys  Ala Gly Ser Asp Gly  Asp Ile Met Asp Ser  Ser Thr Glu 
    1130                 1135                 1140             


Thr Pro  Pro Ile Ser Ile Lys  Ser Arg Thr His Ser  Val Ser Ala 
    1145                 1150                 1155             


Asp Pro  Ser Cys Arg Pro Gly  Pro Gly Gly Gln Gly  Pro Glu Ser 
    1160                 1165                 1170             


Ala Thr  Trp Lys Thr Leu Gly  Gln Gln Leu Asn Ala  Glu Leu Arg 
    1175                 1180                 1185             


Gly Arg  Gly Trp Gly Gln Gln  Asp Gly Pro Gly Pro  Pro Ser Pro 
    1190                 1195                 1200             


Cys Pro  Ser Pro Ser Pro Arg  Arg Thr Ser Pro Ala  Pro Asp Ile 
    1205                 1210                 1215             


Leu Ser  Leu Pro Glu Asp Pro  Cys Leu Gly Pro Arg  Asn Glu Glu 
    1220                 1225                 1230             


Arg Pro  Leu Arg Leu Gln Arg  Ser Pro Val Leu Lys  Arg Arg Pro 
    1235                 1240                 1245             


Lys Leu  Glu Ala Pro Pro Ser  Pro Ser Leu Gly Ser  Gly Leu Gly 
    1250                 1255                 1260             


Ser Lys  Pro Leu Pro Pro Tyr  Pro Thr Glu Pro Ser  Ser Pro Glu 
    1265                 1270                 1275             


Arg Ser  Pro Pro Ser Pro Ala  Thr Asp Gln Arg Gly  Gly Gly Pro 
    1280                 1285                 1290             


Asn Pro  
    1295 


<210>  9
<211>  3295
<212>  DNA
<213>  Homo sapiens

<400>  9
ccgccagccc cgccagtccc cgcgcagtcc ccgcgcagtc cccgcgcagt cccagcgcca       60

ccgggcagca gcggcgccgt gctcgctcca gggcgcaacc atgtcgccat ttcttcggat      120

tggcttgtcc aactttgact gcgggtcctg ccagtcttgt cagggcgagg ctgttaaccc      180

ttactgtgct gtgctcgtca aagagtatgt cgaatcagag aacgggcaga tgtatatcca      240

gaaaaagcct accatgtacc caccctggga cagcactttt gatgcccata tcaacaaggg      300

aagagtcatg cagatcattg tgaaaggcaa aaacgtggac ctcatctctg aaaccaccgt      360

ggagctctac tcgctggctg agaggtgcag gaagaacaac gggaagacag aaatatggtt      420

agagctgaaa cctcaaggcc gaatgctaat gaatgcaaga tactttctgg aaatgagtga      480

cacaaaggac atgaatgaat ttgagacgga aggcttcttt gctttgcatc agcgccgggg      540

tgccatcaag caggcaaagg tccaccacgt caagtgccac gagttcactg ccaccttctt      600

cccacagccc acattttgct ctgtctgcca cgagtttgtc tggggcctga acaaacaggg      660

ctaccagtgc cgacaatgca atgcagcaat tcacaagaag tgtattgata aagttatagc      720

aaagtgcaca ggatcagcta tcaatagccg agaaaccatg ttccacaagg agagattcaa      780

aattgacatg ccacacagat ttaaagtcta caattacaag agcccgacct tctgtgaaca      840

ctgtgggacc ctgctgtggg gactggcacg gcaaggactc aagtgtgatg catgtggcat      900

gaatgtgcat catagatgcc agacaaaggt ggccaacctt tgtggcataa accagaagct      960

aatggctgaa gcgctggcca tgattgagag cactcaacag gctcgctgct taagagatac     1020

tgaacagatc ttcagagaag gtccggttga aattggtctc ccatgctcca tcaaaaatga     1080

agcaaggccg ccatgtttac cgacaccggg aaaaagagag cctcagggca tttcctggga     1140

gtctccgttg gatgaggtgg ataaaatgtg ccatcttcca gaacctgaac tgaacaaaga     1200

aagaccatct ctgcagatta aactaaaaat tgaggatttt atcttgcaca aaatgttggg     1260

gaaaggaagt tttggcaagg tcttcctggc agaattcaag aaaaccaatc aatttttcgc     1320

aataaaggcc ttaaagaaag atgtggtctt gatggacgat gatgttgagt gcacgatggt     1380

agagaagaga gttctttcct tggcctggga gcatccgttt ctgacgcaca tgttttgtac     1440

attccagacc aaggaaaacc tcttttttgt gatggagtac ctcaacggag gggacttaat     1500

gtaccacatc caaagctgcc acaagttcga cctttccaga gcgacgtttt atgctgctga     1560

aatcattctt ggtctgcagt tccttcattc caaaggaata gtctacaggg acctgaagct     1620

agataacatc ctgttagaca aagatggaca tatcaagatc gcggattttg gaatgtgcaa     1680

ggagaacatg ttaggagatg ccaagacgaa taccttctgt gggacacctg actacatcgc     1740

cccagagatc ttgctgggtc agaaatacaa ccactctgtg gactggtggt ccttcggggt     1800

tctcctttat gaaatgctga ttggtcagtc gcctttccac gggcaggatg aggaggagct     1860

cttccactcc atccgcatgg acaatccctt ttacccacgg tggctggaga aggaagcaaa     1920

ggaccttctg gtgaagctct tcgtgcgaga acctgagaag aggctgggcg tgaggggaga     1980

catccgccag caccctttgt ttcgggagat caactgggag gaacttgaac ggaaggagat     2040

tgacccaccg ttccggccga aagtgaaatc accatttgac tgcagcaatt tcgacaaaga     2100

attcttaaac gagaagcccc ggctgtcatt tgccgacaga gcactgatca acagcatgga     2160

ccagaatatg ttcaggaact tttccttcat gaaccccggg atggagcggc tgatatcctg     2220

aatcttgccc ctccagagac aggaaagaat ttgccttctc cctgggaact ggttcaagag     2280

acactgcttg ggttcctttt tcaacttgga aaaagaaaga aacactcaac aataaagact     2340

gagacccgtt cgcccccatg tgacttttat ctgtagcaga aaccaagtct acttcactaa     2400

tgacgatgcc gtgtgtctcg tctcctgaca tgtctcacag acgctcctga agttaggtca     2460

ttactaacca tagttattta cttgaaagat gggtctccgc acttggaaag gtttcaagac     2520

ttgatactgc aataaattat ggctcttcac ctgggcgcca actgctgatc aatgaaatgc     2580

ttgttgaatc aggggcaaac ggagtacaga cgtctcaaga ctgaaacggc cccattgcct     2640

ggtctagtag cggatctcac tcagccgcag acaagtaatc actaacccgt tttattctat     2700

tcctatctgt ggatgtgtaa atggctgggg ggccagccct ggataggttt ttatgggaat     2760

tctttacaat aaacatagct tgtaacttga gatctacaaa tccattcatc ctgattgggc     2820

atgaaatcca tggtcaagag gacaagtgga aagtgagagg gaaggtttgc tagacacctt     2880

cgcttgttat cttgtcaaga tagaaaagat agtatcattt cacccttgcc agtaaaaacc     2940

tttccatcca cccattctca gcagactcca gtattggcac agtcactcac tgccattctc     3000

acactataac aagaaaagaa atgaagtgca taagtctcct gggaaaagaa ccttaacccc     3060

ttctcgtgcc atgactggtg atttcatgac tcataagccc ctccgtaggc atcattcaag     3120

atcaatggcc catgcatgct gtttgcagca gtcaattgag ttgaattaga attccaacca     3180

tacattttaa aggtatttgt gctgtgtgta tattttgata aaatgttgtg acttcatggc     3240

aaacaggtgg atgtgtaaaa atggaataaa aaaaaaaaaa gagtcaaaaa aaaaa          3295


<210>  10
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Ser 
1               5                   10                  15      


Cys Gln Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 
            20                  25                  30          


Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 
        35                  40                  45              


Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile 
    50                  55                  60                  


Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val Asp 
65                  70                  75                  80  


Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg Cys 
                85                  90                  95      


Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu Leu Lys Pro Gln 
            100                 105                 110         


Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp Thr 
        115                 120                 125             


Lys Asp Met Asn Glu Phe Glu Thr Glu Gly Phe Phe Ala Leu His Gln 
    130                 135                 140                 


Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His 
145                 150                 155                 160 


Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 
                165                 170                 175     


His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 
            180                 185                 190         


Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys 
        195                 200                 205             


Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys Glu 
    210                 215                 220                 


Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Lys 
225                 230                 235                 240 


Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 
                245                 250                 255     


Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 
            260                 265                 270         


Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 
        275                 280                 285             


Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys Leu 
    290                 295                 300                 


Arg Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu 
305                 310                 315                 320 


Pro Cys Ser Ile Lys Asn Glu Ala Arg Pro Pro Cys Leu Pro Thr Pro 
                325                 330                 335     


Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro Leu Asp Glu 
            340                 345                 350         


Val Asp Lys Met Cys His Leu Pro Glu Pro Glu Leu Asn Lys Glu Arg 
        355                 360                 365             


Pro Ser Leu Gln Ile Lys Leu Lys Ile Glu Asp Phe Ile Leu His Lys 
    370                 375                 380                 


Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys 
385                 390                 395                 400 


Lys Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 
                405                 410                 415     


Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
            420                 425                 430         


Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe 
        435                 440                 445             


Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly Gly 
    450                 455                 460                 


Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser Arg 
465                 470                 475                 480 


Ala Thr Phe Tyr Ala Ala Glu Ile Ile Leu Gly Leu Gln Phe Leu His 
                485                 490                 495     


Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
            500                 505                 510         


Asp Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
        515                 520                 525             


Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 
    530                 535                 540                 


Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val 
545                 550                 555                 560 


Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln 
                565                 570                 575     


Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile Arg 
            580                 585                 590         


Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Lys Glu Ala Lys Asp 
        595                 600                 605             


Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 
    610                 615                 620                 


Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu 
625                 630                 635                 640 


Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 
                645                 650                 655     


Ser Pro Phe Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu Lys 
            660                 665                 670         


Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln 
        675                 680                 685             


Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu Arg Leu 
    690                 695                 700                 


Ile Ser 
705     


<210>  11
<211>  3313
<212>  DNA
<213>  Mus musculus

<400>  11
cttgggtcgc caggcccgcg ccagtccccg ccatccgagc aacagcggcg ctgctctggg       60

accgcggccg cgacaccagg gaacaaccat gtcaccgttt cttcgaatcg gtttatccaa      120

ctttgactgt gggacctgcc aagcttgtca gggagaggca gtgaacccct actgcgctgt      180

gcttgtcaaa gagtatgtgg aatcagaaaa tgggcagatg tacatccaga aaaagccaac      240

catgtaccca ccttgggaca gcacctttga cgcccacatt aacaagggaa gggtgatgca      300

gatcatcgtg aagggcaaga atgtagacct catctcagaa acaaccgtgg aactctactc      360

cctggcggag agatgccgca agaacaatgg gcggacagaa atatggttag agctgaaacc      420

tcaaggccga atgctaatga atgcaagata ctttctggaa atgagtgaca caaaggacat      480

gagtgagttt gagaatgaag gattctttgc actgcatcag cgccgaggag ccatcaaaca      540

ggccaaagtc caccatgtca agtgtcacga gttcacggcc acctttttcc ctcaacccac      600

attttgctct gtctgccatg aatttgtctg gggcctgaac aagcagggtt accagtgccg      660

acagtgtaat gcagcgattc acaagaagtg cattgataaa gtgatagcca agtgcacagg      720

atccgcaatc aatagccgag aaaccatgtt ccataaggag agattcaaga tcgacatgcc      780

acacagattc aaagtctaca actacaagag tccaaccttc tgtgagcact gtggtaccct      840

gctctggggg ctggcgaggc aaggactcaa atgtgatgca tgtggcatga acgtccacca      900

ccgatgccag acaaaggttg ccaatctttg tggtataaac cagaagctaa tggctgaagc      960

actagcgatg attgaaagca cccaacaggc tcgctcctta cgagattcag aacacatctt     1020

ccgagaaggc ccagttgaaa ttggtctccc atgctccacc aaaaacgaaa ccaggccacc     1080

atgcgtacca acacctggga aaagagaacc ccagggcatt tcctgggatt cccctttgga     1140

tgggtcaaat aaatcggccg gtcctcctga acccgaagtg agcatgcgca ggacttcact     1200

gcagctgaaa ctgaagatcg atgacttcat cctgcacaag atgttgggaa aaggaagttt     1260

tggcaaggtc ttcctggcag agttcaagag aaccaatcag tttttcgcaa taaaagcctt     1320

aaagaaagat gtggtgttga tggatgatga cgtcgagtgt acaatggtgg aaaagagggt     1380

tctgtccttg gcatgggagc atccatttct aacacacatg ttctgcacat tccagaccaa     1440

ggaaaatctc tttttcgtga tggagtatct caatggaggc gacttaatgt accacatcca     1500

aagttgccac aaatttgatc tttccagagc cacgttttat gctgctgagg tcatccttgg     1560

tctgcagttc cttcattcca aaggaattgt ctacagggac ctgaagcttg ataatatcct     1620

gttagacaga gatggacata tcaaaatagc agactttggg atgtgcaaag agaacatgct     1680

aggagatgcg aagacaaata ctttctgtgg aactcctgac tacattgctc cggagatctt     1740

gctgggtcag aagtacaacc attccgtcga ctggtggtcc ttcggggtgc tcgtttatga     1800

gatgctgatt ggccagtccc ccttccacgg gcaggacgag gaggagctgt tccactccat     1860

ccgcatggac aaccccttct acccgaggtg gctcgaaagg gaggccaagg accttctagt     1920

gaagcttttt gtgagagaac ctgagaagag gctgggagtg agaggagaca tccgccagca     1980

tcctttgttt cgagagatca actgggaaga gcttgaaagg aaagagattg acccaccctt     2040

cagaccaaaa gtgaaatcac catatgactg tagcaatttc gacaaggaat tcctaagtga     2100

gaaaccccgg ctatcattcg ccgacagagc actcatcaac agcatggacc agaacatgtt     2160

cagcaacttt tccttcatta acccagggat ggagactctc atttgctcct gaacctcatc     2220

tgtctccaga ctggaaggga tttgccttct ctctgggaac tggttcaagt aacacttctg     2280

ggggtggggg tctctttttc acgttagaga agaaaagaaa cactgcaaag gcagggagga     2340

ctgctgagct ccttgtgtga cttgttacct acagcacaaa ccacgcctac ttcactaatg     2400

acatcatccc taatgacatc atcccgttat atctcctgga atctctcaca gcagcccttg     2460

aagttagatc attattaact ctagtcattt acttgaaaga tggttcccga tgctgtgaaa     2520

gattcgaaat gcagttctgc tcttgcccta gacaacagct gctggttggt gatgaaccaa     2580

ggcgcaagtg gaacagattt ctcaagactg gagcagtgat cgcctgttat agaagtcaat     2640

tccactcaac cacagagaag gaaccactaa gccacgttga tgtgtgcatg tctgtggaaa     2700

tgtcgatgac agaagggagg gaaaggggaa gctctgagca gattgtaatg ggaagctctc     2760

caataaacat agcatgaaac ttgaaattta caaatctgtt cattctggct agccccaaaa     2820

ttcccaaggc agaggaaagt aaagggcagt gagcttagca gagccctttg tcgccaacag     2880

ggaagggtaa ggatgtcgcc tacgtggaac atcttataca cacagaagga aagtataacc     2940

aacaagggca gggtggttta cagctgccaa tcaaacctgc cctcccccct ctgttctcag     3000

ttgatctctc tgtcagcgta ggtaggcact cattaccatc ctcccatcat acaagaaata     3060

aaatgcatga ctcttctaag ataaagaaaa ccaatccctt atcacgttgt tcccagtgat     3120

ttgatggcaa ataagtccct ccttaggcat cctgcaagac aacccaaccc atgcatgcta     3180

tttgcagtag tcagtcctgt tgagttagag tcctaactat acacaatatc gtgcgatgtt     3240

tatatatgtt gatgagatgt tgtgatgata acgtggatat gtaaaaggga ataaaagaag     3300

aaagaaagat gcc                                                        3313


<210>  12
<211>  707
<212>  PRT
<213>  Mus musculus

<400>  12

Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Thr 
1               5                   10                  15      


Cys Gln Ala Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 
            20                  25                  30          


Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 
        35                  40                  45              


Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile 
    50                  55                  60                  


Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val Asp 
65                  70                  75                  80  


Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg Cys 
                85                  90                  95      


Arg Lys Asn Asn Gly Arg Thr Glu Ile Trp Leu Glu Leu Lys Pro Gln 
            100                 105                 110         


Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp Thr 
        115                 120                 125             


Lys Asp Met Ser Glu Phe Glu Asn Glu Gly Phe Phe Ala Leu His Gln 
    130                 135                 140                 


Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His 
145                 150                 155                 160 


Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 
                165                 170                 175     


His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 
            180                 185                 190         


Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys 
        195                 200                 205             


Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys Glu 
    210                 215                 220                 


Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Lys 
225                 230                 235                 240 


Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 
                245                 250                 255     


Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 
            260                 265                 270         


Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 
        275                 280                 285             


Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Ser Leu 
    290                 295                 300                 


Arg Asp Ser Glu His Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu 
305                 310                 315                 320 


Pro Cys Ser Thr Lys Asn Glu Thr Arg Pro Pro Cys Val Pro Thr Pro 
                325                 330                 335     


Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Asp Ser Pro Leu Asp Gly 
            340                 345                 350         


Ser Asn Lys Ser Ala Gly Pro Pro Glu Pro Glu Val Ser Met Arg Arg 
        355                 360                 365             


Thr Ser Leu Gln Leu Lys Leu Lys Ile Asp Asp Phe Ile Leu His Lys 
    370                 375                 380                 


Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys 
385                 390                 395                 400 


Arg Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 
                405                 410                 415     


Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
            420                 425                 430         


Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe 
        435                 440                 445             


Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly Gly 
    450                 455                 460                 


Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser Arg 
465                 470                 475                 480 


Ala Thr Phe Tyr Ala Ala Glu Val Ile Leu Gly Leu Gln Phe Leu His 
                485                 490                 495     


Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
            500                 505                 510         


Asp Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
        515                 520                 525             


Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 
    530                 535                 540                 


Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val 
545                 550                 555                 560 


Asp Trp Trp Ser Phe Gly Val Leu Val Tyr Glu Met Leu Ile Gly Gln 
                565                 570                 575     


Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile Arg 
            580                 585                 590         


Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Arg Glu Ala Lys Asp 
        595                 600                 605             


Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 
    610                 615                 620                 


Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu 
625                 630                 635                 640 


Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 
                645                 650                 655     


Ser Pro Tyr Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Ser Glu Lys 
            660                 665                 670         


Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln 
        675                 680                 685             


Asn Met Phe Ser Asn Phe Ser Phe Ile Asn Pro Gly Met Glu Thr Leu 
    690                 695                 700                 


Ile Cys Ser 
705         


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  13
ccagagagag gaagccgaa                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  14
aggaagagau ggcucguca                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  15
gucuugaccu ugaacggaa                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  16
aagcaggagu caaacgagu                                                    19


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide

<400>  17

Ile Gly Val Ser Arg Gly Ser Gly Gly Ala Glu Gly Lys 
1               5                   10              


