                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> TREATMENT SELECTION AND ASSESSMENT OF THERAPEUTIC RESPONSE TO 
      PROGRAMMED CELL DEATH 1 (PD-1) INHIBITOR THERAPY FOR PATIENTS 
      WITH PD-1-EXPRESSING CANCERS

<130> 043214-085711-PCT

<140>
<141>

<150> 62/214,224
<151> 2015-09-04

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 845
<212> DNA
<213> Homo sapiens

<400> 1
cctcggaggc gttcagctgc ttcaagatga agctgaacat ctccttccca gccactggct       60

gccagaaact cattgaagtg gacgatgaac gcaaacttcg tactttctat gagaagcgta      120

tggccacaga agttgctgct gacgctctgg gtgaagaatg gaagggttat gtggtccgaa      180

tcagtggtgg gaacgacaaa caaggtttcc ccatgaagca gggtgtcttg acccatggcc      240

gtgtccgcct gctactgagt aaggggcatt cctgttacag accaaggaga actggagaaa      300

gaaagagaaa atcagttcgt ggttgcattg tggatgcaaa tctgagcgtt ctcaacttgg      360

ttattgtaaa aaaaggagag aaggatattc ctggactgac tgatactaca gtgcctcgcc      420

gcctgggccc caaaagagct agcagaatcc gcaaactttt caatctctct aaagaagatg      480

atgtccgcca gtatgttgta agaaagccct taaataaaga aggtaagaaa cctaggacca      540

aagcacccaa gattcagcgt cttgttactc cacgtgtcct gcagcacaaa cggcggcgta      600

ttgctctgaa gaagcagcgt accaagaaaa ataaagaaga ggctgcagaa tatgctaaac      660

ttttggccaa gagaatgaag gaggctaagg agaagcgcca ggaacaaatt gcgaagagac      720

gcagactttc ctctctgcga gcttctactt ctaagtctga atccagtcag aaataagatt      780

ttttgagtaa caaataaata agatcagact ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaa                                                                  845


<210> 2
<211> 249
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Leu Asn Ile Ser Phe Pro Ala Thr Gly Cys Gln Lys Leu Ile 
1               5                   10                  15      


Glu Val Asp Asp Glu Arg Lys Leu Arg Thr Phe Tyr Glu Lys Arg Met 
            20                  25                  30          


Ala Thr Glu Val Ala Ala Asp Ala Leu Gly Glu Glu Trp Lys Gly Tyr 
        35                  40                  45              


Val Val Arg Ile Ser Gly Gly Asn Asp Lys Gln Gly Phe Pro Met Lys 
    50                  55                  60                  


Gln Gly Val Leu Thr His Gly Arg Val Arg Leu Leu Leu Ser Lys Gly 
65                  70                  75                  80  


His Ser Cys Tyr Arg Pro Arg Arg Thr Gly Glu Arg Lys Arg Lys Ser 
                85                  90                  95      


Val Arg Gly Cys Ile Val Asp Ala Asn Leu Ser Val Leu Asn Leu Val 
            100                 105                 110         


Ile Val Lys Lys Gly Glu Lys Asp Ile Pro Gly Leu Thr Asp Thr Thr 
        115                 120                 125             


Val Pro Arg Arg Leu Gly Pro Lys Arg Ala Ser Arg Ile Arg Lys Leu 
    130                 135                 140                 


Phe Asn Leu Ser Lys Glu Asp Asp Val Arg Gln Tyr Val Val Arg Lys 
145                 150                 155                 160 


Pro Leu Asn Lys Glu Gly Lys Lys Pro Arg Thr Lys Ala Pro Lys Ile 
                165                 170                 175     


Gln Arg Leu Val Thr Pro Arg Val Leu Gln His Lys Arg Arg Arg Ile 
            180                 185                 190         


Ala Leu Lys Lys Gln Arg Thr Lys Lys Asn Lys Glu Glu Ala Ala Glu 
        195                 200                 205             


Tyr Ala Lys Leu Leu Ala Lys Arg Met Lys Glu Ala Lys Glu Lys Arg 
    210                 215                 220                 


Gln Glu Gln Ile Ala Lys Arg Arg Arg Leu Ser Ser Leu Arg Ala Ser 
225                 230                 235                 240 


Thr Ser Lys Ser Glu Ser Ser Gln Lys 
                245                 


<210> 3
<211> 2610
<212> DNA
<213> Homo sapiens

<400> 3
atcctgggac agggcacagg gccatctgtc accaggggct tagggaaggc cgagccagcc       60

tgggtcaaag aagtcaaagg ggctgcctgg aggaggcagc ctgtcagctg gtgcatcaga      120

ggctgtggcc aggccagctg ggctcgggga gcgccagcct gagaggagcg cgtgagcgtc      180

gcgggagcct cgggcaccat gagcgacgtg gctattgtga aggagggttg gctgcacaaa      240

cgaggggagt acatcaagac ctggcggcca cgctacttcc tcctcaagaa tgatggcacc      300

ttcattggct acaaggagcg gccgcaggat gtggaccaac gtgaggctcc cctcaacaac      360

ttctctgtgg cgcagtgcca gctgatgaag acggagcggc cccggcccaa caccttcatc      420

atccgctgcc tgcagtggac cactgtcatc gaacgcacct tccatgtgga gactcctgag      480

gagcgggagg agtggacaac cgccatccag actgtggctg acggcctcaa gaagcaggag      540

gaggaggaga tggacttccg gtcgggctca cccagtgaca actcaggggc tgaagagatg      600

gaggtgtccc tggccaagcc caagcaccgc gtgaccatga acgagtttga gtacctgaag      660

ctgctgggca agggcacttt cggcaaggtg atcctggtga aggagaaggc cacaggccgc      720

tactacgcca tgaagatcct caagaaggaa gtcatcgtgg ccaaggacga ggtggcccac      780

acactcaccg agaaccgcgt cctgcagaac tccaggcacc ccttcctcac agccctgaag      840

tactctttcc agacccacga ccgcctctgc tttgtcatgg agtacgccaa cgggggcgag      900

ctgttcttcc acctgtcccg ggaacgtgtg ttctccgagg accgggcccg cttctatggc      960

gctgagattg tgtcagccct ggactacctg cactcggaga agaacgtggt gtaccgggac     1020

ctcaagctgg agaacctcat gctggacaag gacgggcaca ttaagatcac agacttcggg     1080

ctgtgcaagg aggggatcaa ggacggtgcc accatgaaga ccttttgcgg cacacctgag     1140

tacctggccc ccgaggtgct ggaggacaat gactacggcc gtgcagtgga ctggtggggg     1200

ctgggcgtgg tcatgtacga gatgatgtgc ggtcgcctgc ccttctacaa ccaggaccat     1260

gagaagcttt ttgagctcat cctcatggag gagatccgct tcccgcgcac gcttggtccc     1320

gaggccaagt ccttgctttc agggctgctc aagaaggacc ccaagcagag gcttggcggg     1380

ggctccgagg acgccaagga gatcatgcag catcgcttct ttgccggtat cgtgtggcag     1440

cacgtgtacg agaagaagct cagcccaccc ttcaagcccc aggtcacgtc ggagactgac     1500

accaggtatt ttgatgagga gttcacggcc cagatgatca ccatcacacc acctgaccaa     1560

gatgacagca tggagtgtgt ggacagcgag cgcaggcccc acttccccca gttctcctac     1620

tcggccagca gcacggcctg aggcggcggt ggactgcgct ggacgatagc ttggagggat     1680

ggagaggcgg cctcgtgcca tgatctgtat ttaatggttt ttatttctcg ggtgcatttg     1740

agagaagcca cgctgtcctc tcgagcccag atggaaagac gtttttgtgc tgtgggcagc     1800

accctccccc gcagcggggt agggaagaaa actatcctgc gggttttaat ttatttcatc     1860

cagtttgttc tccgggtgtg gcctcagccc tcagaacaat ccgattcacg tagggaaatg     1920

ttaaggactt ctacagctat gcgcaatgtg gcattggggg gccgggcagg tcctgcccat     1980

gtgtcccctc actctgtcag ccagccgccc tgggctgtct gtcaccagct atctgtcatc     2040

tctctggggc cctgggcctc agttcaacct ggtggcacca gatgcaacct cactatggta     2100

tgctggccag caccctctcc tgggggtggc aggcacacag cagcccccca gcactaaggc     2160

cgtgtctctg aggacgtcat cggaggctgg gcccctggga tgggaccagg gatgggggat     2220

gggccagggt ttacccagtg ggacagagga gcaaggttta aatttgttat tgtgtattat     2280

gttgttcaaa tgcattttgg gggtttttaa tctttgtgac aggaaagccc tcccccttcc     2340

ccttctgtgt cacagttctt ggtgactgtc ccaccggagc ctccccctca gatgatctct     2400

ccacggtagc acttgacctt ttcgacgctt aacctttccg ctgtcgcccc aggccctccc     2460

tgactccctg tgggggtggc catccctggg cccctccacg cctcctggcc agacgctgcc     2520

gctgccgctg caccacggcg tttttttaca acattcaact ttagtatttt tactattata     2580

atataatatg gaaccttccc tccaaattct                                      2610


<210> 4
<211> 480
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ser Thr Ala 
465                 470                 475                 480 


<210> 5
<211> 724
<212> PRT
<213> Homo sapiens

<400> 5
Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
1               5                   10                  15      


Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
        35                  40                  45              


Arg Pro Glu Glu Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
    50                  55                  60                  


Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
65                  70                  75                  80  


Lys Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                85                  90                  95      


Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Val Glu Gln Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Ile Ala 
        115                 120                 125             


Pro Pro Leu Leu Ile Lys Leu Val Glu Ala Ile Glu Lys Lys Gly Leu 
    130                 135                 140                 


Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Leu Ala Glu 
145                 150                 155                 160 


Leu Arg Gln Leu Leu Asp Cys Asp Thr Pro Ser Val Asp Leu Glu Met 
                165                 170                 175     


Ile Asp Val His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Leu Asp 
            180                 185                 190         


Leu Pro Asn Pro Val Ile Pro Ala Ala Val Tyr Ser Glu Met Ile Ser 
        195                 200                 205             


Leu Ala Pro Glu Val Gln Ser Ser Glu Glu Tyr Ile Gln Leu Leu Lys 
    210                 215                 220                 


Lys Leu Ile Arg Ser Pro Ser Ile Pro His Gln Tyr Trp Leu Thr Leu 
225                 230                 235                 240 


Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Thr Ser Ser Lys 
                245                 250                 255     


Asn Leu Leu Asn Ala Arg Val Leu Ser Glu Ile Phe Ser Pro Met Leu 
            260                 265                 270         


Phe Arg Phe Ser Ala Ala Ser Ser Asp Asn Thr Glu Asn Leu Ile Lys 
        275                 280                 285             


Val Ile Glu Ile Leu Ile Ser Thr Glu Trp Asn Glu Arg Gln Pro Ala 
    290                 295                 300                 


Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Thr Val Ala Asn Asn 
305                 310                 315                 320 


Gly Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                325                 330                 335     


Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
            340                 345                 350         


Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
        355                 360                 365             


Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
    370                 375                 380                 


His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Ser Ser 
385                 390                 395                 400 


Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                405                 410                 415     


Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
            420                 425                 430         


Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
        435                 440                 445             


Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
    450                 455                 460                 


Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
465                 470                 475                 480 


Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu 
                485                 490                 495     


Gln Cys Gln Thr Gln Glu Arg Tyr Ser Lys Glu Tyr Ile Glu Lys Phe 
            500                 505                 510         


Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn Tyr 
        515                 520                 525             


Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
    530                 535                 540                 


Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
545                 550                 555                 560 


Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                565                 570                 575     


Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
            580                 585                 590         


Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
        595                 600                 605             


Leu Val Glu Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
    610                 615                 620                 


Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
625                 630                 635                 640 


Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                645                 650                 655     


Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
            660                 665                 670         


Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
        675                 680                 685             


Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
    690                 695                 700                 


Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
705                 710                 715                 720 


Gln Gln Arg Arg 
                


<210> 6
<211> 2430
<212> DNA
<213> Homo sapiens

<400> 6
agagagagaa actccgggac actcccgatg gcaccttcct agtccgagat gcttctagca       60

agatccaggg cgagtacacg ctgaccctca ggaaaggcgg gaacaataag ctgatcaagg      120

tcttccaccg agatgggcac tatggcttct cagagccact caccttctgc tccgttgtgg      180

acctcatcaa tcactaccgc cacgagtctc tggcccagta caatgccaag ctggacacac      240

ggctcctcta ccctgtgtcc aaataccagc aggaccagat tgtcaaggag gacagcgtgg      300

aggcagtggg cgcccagctt aaggtctatc accagcagta ccaggacaag agccgcgagt      360

atgaccagct ttatgaagag tacacacgga cctcccagga gctgcagatg aagcgtactg      420

caattgaggc cttcaatgag actatcaaga tctttgaaga gcagggccag actcaagaga      480

aatgcagcaa ggaatacctg gagcgcttcc ggcgtgaggg caacgagaaa gagatgcaaa      540

ggatcctgct gaactccgag cggctcaagt cccgcattgc cgagatccat gagagccgca      600

cgaagctgga gcagcagctg cgggcccagg cctcggacaa cagagagatc gacaagcgca      660

tgaacagcct caagccggac ctcatgcagc tgcgcaagat ccgagaccag tacctcgtgt      720

ggctcaccca gaaaggcgcc cggcagaaga aaatcaacga gtggctgggg attaaaaatg      780

agactgagga ccagtacgca ctcatggagg acgaggacga tctcccgcac cacgaggaac      840

gcacttggta cgtgggcaag atcaaccgca cgcaggcaga ggagatgctg agcggcaagc      900

gggatggcac cttcctcatc cgcgagagca gccagcgggg ctgctacgcc tgctccgtgg      960

tagtggacgg cgacaccaag cactgcgtca tctaccgcac ggccaccggc ttcggcttcg     1020

cggagcccta caacctgtac gggtcgctga aggagctggt gctgcactac cagcacgcct     1080

cgctggtgca gcacaacgac gcgctcaccg tcaccctggc gcacccagtg cgcgccccgg     1140

gccccggccc gccgcctgcc gcccgctgag caccgaggac ccgccccaag cagagccgcc     1200

cctgggcccg tctgcgccgg aggctgcggc ggcgggagcc acggaccaga ccagccacat     1260

ccaggggtcc tcatttctcc ggctctggct cttgtttggg gttctctcac cctctttctc     1320

tttccttccc tcccccattc tccagatctc cctctgtctc cttttctctg tctttcttgg     1380

cccctgtctc tctccatgtt gggggtccta actcccccac cccatatcta cgtgtcctcc     1440

gggcattgcc ctctccatgg ctctggtcac cctgaccctc tgccctgccc accgcaggtc     1500

ccccggggtc ccggaagccc cttctggctg cacctgccat gtttacagag ggcccctggg     1560

ctgcgcggcc ccagcctggg caccctgatt tttaagccat agacctgggg tcagggcagg     1620

aaggaacttc actctgctgc ttccgagaac ctcggccgtg acattcgggg ccgggcggga     1680

cccgccccac agactccaac ttcccctcca aaccccgaag tgaaacccgc caccgggtta     1740

cccccacaag ggggccgctg cgagaagttc acccaccccc gaaaaaataa ttaaactcgc     1800

aggccaggca cggtggctca tgcctgtaat cccagcactt tgggaggcca agacgggcgg     1860

atcttttgag gtcgggagtt ggaggccagc ctggccaaaa tggcaaaacc ccgcatctac     1920

taaaatacaa aaattagccg ggcgtggtgg cggccgcctg taatcccagc tacttgggag     1980

gctgaggcgt gagaatctct tgaacccagg agatggaggt tgcagtgagc agagatcgtg     2040

ccactgcact ccagcctggg taacagaggg agactcctcc gtctcaaaaa aataaataaa     2100

taaacttgtg agctggcccc aacccctcct aggaatcaca gctccccgta ctggtgccgc     2160

cgcagtggcc aagttgcgac actgcccacg gcccctccct ctgatgcaga ttcagggctt     2220

ctcttcgatc atgttgggtt ttgattctgt ttttccttga ctgcaaaacc ctctttcctc     2280

tcctcttttg ggacaagagc cctggttttc tacgctgccc ttggccacca cactgcctgc     2340

cccacgagct gggaggcagg ttttgtacgg tacgttgtta ttgatatgat ataaaacatc     2400

aaacgtcaaa aaaaaaaaaa aaaaaaaaaa                                      2430


<210> 7
<211> 728
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Gly Pro Glu Gly Phe Gln Tyr Arg Ala Leu Tyr Pro Phe Arg 
1               5                   10                  15      


Arg Glu Arg Pro Glu Asp Leu Glu Leu Leu Pro Gly Asp Val Leu Val 
            20                  25                  30          


Val Ser Arg Ala Ala Leu Gln Ala Leu Gly Val Ala Glu Gly Gly Glu 
        35                  40                  45              


Arg Cys Pro Gln Ser Val Gly Trp Met Pro Gly Leu Asn Glu Arg Thr 
    50                  55                  60                  


Arg Gln Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Phe Leu Gly Pro 
65                  70                  75                  80  


Val Ala Leu Ala Arg Pro Gly Pro Arg Pro Arg Gly Pro Arg Pro Leu 
                85                  90                  95      


Pro Ala Arg Pro Arg Asp Gly Ala Pro Glu Pro Gly Leu Thr Leu Pro 
            100                 105                 110         


Asp Leu Pro Glu Gln Phe Ser Pro Pro Asp Val Ala Pro Pro Leu Leu 
        115                 120                 125             


Val Lys Leu Val Glu Ala Ile Glu Arg Thr Gly Leu Asp Ser Glu Ser 
    130                 135                 140                 


His Tyr Arg Pro Glu Leu Pro Ala Pro Arg Thr Asp Trp Ser Leu Ser 
145                 150                 155                 160 


Asp Val Asp Gln Trp Asp Thr Ala Ala Leu Ala Asp Gly Ile Lys Ser 
                165                 170                 175     


Phe Leu Leu Ala Leu Pro Ala Pro Leu Val Thr Pro Glu Ala Ser Ala 
            180                 185                 190         


Glu Ala Arg Arg Ala Leu Arg Glu Ala Ala Gly Pro Val Gly Pro Ala 
        195                 200                 205             


Leu Glu Pro Pro Thr Leu Pro Leu His Arg Ala Leu Thr Leu Arg Phe 
    210                 215                 220                 


Leu Leu Gln His Leu Gly Arg Val Ala Ser Arg Ala Pro Ala Leu Gly 
225                 230                 235                 240 


Pro Ala Val Arg Ala Leu Gly Ala Thr Phe Gly Pro Leu Leu Leu Arg 
                245                 250                 255     


Ala Pro Pro Pro Pro Ser Ser Pro Pro Pro Gly Gly Ala Pro Asp Gly 
            260                 265                 270         


Ser Glu Pro Ser Pro Asp Phe Pro Ala Leu Leu Val Glu Lys Leu Leu 
        275                 280                 285             


Gln Glu His Leu Glu Glu Gln Glu Val Ala Pro Pro Ala Leu Pro Pro 
    290                 295                 300                 


Lys Pro Pro Lys Ala Lys Pro Ala Ser Thr Val Leu Ala Asn Gly Gly 
305                 310                 315                 320 


Ser Pro Pro Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly Asp Ile Ser 
                325                 330                 335     


Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Pro Asp Gly Thr Phe 
            340                 345                 350         


Leu Val Arg Asp Ala Ser Ser Lys Ile Gln Gly Glu Tyr Thr Leu Thr 
        355                 360                 365             


Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Val Phe His Arg Asp 
    370                 375                 380                 


Gly His Tyr Gly Phe Ser Glu Pro Leu Thr Phe Cys Ser Val Val Asp 
385                 390                 395                 400 


Leu Ile Asn His Tyr Arg His Glu Ser Leu Ala Gln Tyr Asn Ala Lys 
                405                 410                 415     


Leu Asp Thr Arg Leu Leu Tyr Pro Val Ser Lys Tyr Gln Gln Asp Gln 
            420                 425                 430         


Ile Val Lys Glu Asp Ser Val Glu Ala Val Gly Ala Gln Leu Lys Val 
        435                 440                 445             


Tyr His Gln Gln Tyr Gln Asp Lys Ser Arg Glu Tyr Asp Gln Leu Tyr 
    450                 455                 460                 


Glu Glu Tyr Thr Arg Thr Ser Gln Glu Leu Gln Met Lys Arg Thr Ala 
465                 470                 475                 480 


Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu Gln Gly Gln 
                485                 490                 495     


Thr Gln Glu Lys Cys Ser Lys Glu Tyr Leu Glu Arg Phe Arg Arg Glu 
            500                 505                 510         


Gly Asn Glu Lys Glu Met Gln Arg Ile Leu Leu Asn Ser Glu Arg Leu 
        515                 520                 525             


Lys Ser Arg Ile Ala Glu Ile His Glu Ser Arg Thr Lys Leu Glu Gln 
    530                 535                 540                 


Gln Leu Arg Ala Gln Ala Ser Asp Asn Arg Glu Ile Asp Lys Arg Met 
545                 550                 555                 560 


Asn Ser Leu Lys Pro Asp Leu Met Gln Leu Arg Lys Ile Arg Asp Gln 
                565                 570                 575     


Tyr Leu Val Trp Leu Thr Gln Lys Gly Ala Arg Gln Lys Lys Ile Asn 
            580                 585                 590         


Glu Trp Leu Gly Ile Lys Asn Glu Thr Glu Asp Gln Tyr Ala Leu Met 
        595                 600                 605             


Glu Asp Glu Asp Asp Leu Pro His His Glu Glu Arg Thr Trp Tyr Val 
    610                 615                 620                 


Gly Lys Ile Asn Arg Thr Gln Ala Glu Glu Met Leu Ser Gly Lys Arg 
625                 630                 635                 640 


Asp Gly Thr Phe Leu Ile Arg Glu Ser Ser Gln Arg Gly Cys Tyr Ala 
                645                 650                 655     


Cys Ser Val Val Val Asp Gly Asp Thr Lys His Cys Val Ile Tyr Arg 
            660                 665                 670         


Thr Ala Thr Gly Phe Gly Phe Ala Glu Pro Tyr Asn Leu Tyr Gly Ser 
        675                 680                 685             


Leu Lys Glu Leu Val Leu His Tyr Gln His Ala Ser Leu Val Gln His 
    690                 695                 700                 


Asn Asp Ala Leu Thr Val Thr Leu Ala His Pro Val Arg Ala Pro Gly 
705                 710                 715                 720 


Pro Gly Pro Pro Pro Ala Ala Arg 
                725             


<210> 8
<211> 2427
<212> DNA
<213> Homo sapiens

<400> 8
attacaaaga aagccggact cttttcttat aactgagctc agccaaggaa actcttgcac       60

aaatgtacaa tactgtttgg aatatggaag acctggattt agaatatgcc aagacagata      120

taaattgtgg cacagacttg atgttttata tagaaatgga cccaccagca ctgcctccta      180

aaccaccaaa acctactact gtagccaaca acggtatgaa taacaatatg tccttacaag      240

atgctgaatg gtactgggga gatatctcga gggaagaagt gaatgaaaaa cttcgagata      300

cagcagacgg gacctttttg gtacgagatg cgtctactaa aatgcatggt gattatactc      360

ttacactaag gaaaggggga aataacaaat taatcaaaat atttcatcga gatgggaaat      420

atggcttctc tgacccatta accttcagtt ctgtggttga attaataaac cactaccgga      480

atgaatctct agctcagtat aatcccaaat tggatgtgaa attactttat ccagtatcca      540

aataccaaca ggatcaagtt gtcaaagaag ataatattga agctgtaggg aaaaaattac      600

ataaatataa cactcagttt caagaaaaaa gtcgagaata tgatagatta tatgaagaat      660

atacccgcac atcccaggaa atccaaatga aaaggacagc tattgaagca tttaatgaaa      720

ccataaaaat atttgaagaa cagtgccaga cccaagagcg gtacagcaaa gaatacatag      780

aaaagtttaa acgtgaaggc aatgagaaag aaatacaaag gattatgcat aattatgata      840

agttgaagtc tcgaatcagt gaaattattg acagtagaag aagattggaa gaagacttga      900

agaagcaggc agctgagtat cgagaaattg acaaacgtat gaacagcatt aaaccagacc      960

ttatccagct gagaaagacg agagaccaat acttgatgtg gttgactcaa aaaggtgttc     1020

ggcaaaagaa gttgaacgag tggttgggca atgaaaacac tgaagaccaa tattcactgg     1080

tggaagatga tgaagatttg ccccatcatg atgagaagac atggaatgtt ggaagcagca     1140

accgaaacaa agctgaaaac ctgttgcgag ggaagcgaga tggcactttt cttgtccggg     1200

agagcagtaa acagggctgc tatgcctgct ctgtagtggt ggacggcgaa gtaaagcatt     1260

gtgtcataaa caaaacagca actggctatg gctttgccga gccctataac ttgtacagct     1320

ctctgaaaga actggtgcta cattaccaac acacctccct tgtgcagcac aacgactccc     1380

tcaatgtcac actagcctac ccagtatatg cacagcagag gcgatgaagc gcttactctt     1440

tgatccttct cctgaagttc agccaccctg aggcctctgg aaagcaaagg gctcctctcc     1500

agtctgatct gtgaattgag ctgcagaaac gaagccatct ttctttggat gggactagag     1560

ctttctttca caaaaaagaa gtaggggaag acatgcagcc taaggctgta tgatgaccac     1620

acgttcctaa gctggagtgc ttatcccttc tttttctttt tttctttggt ttaatttaaa     1680

gccacaacca catacaacac aaagagaaaa agaaatgcaa aaatctctgc gtgcagggac     1740

aaagaggcct ttaaccatgg tgcttgttaa tgctttctga agctttacca gctgaaagtt     1800

gggactctgg agagcggagg agagagaggc agaagaaccc tggcctgaga aggtttggtc     1860

cagcctggtt tagcctggat gttgctgtgc acggtggacc cagacacatc gcactgtgga     1920

ttatttcatt ttgtaacaaa tgaacgatat gtagcagaaa ggcacgtcca ctcacaaggg     1980

acgctttggg agaatgtcag ttcatgtatg ttcagaagaa attctgtcat agaaagtgcc     2040

agaaagtgtt taacttgtca aaaaacaaaa acccagcaac agaaaaatgg agtttggaaa     2100

acaggactta aaatgacatt cagtatataa aatatgtaca taatattgga tgactaacta     2160

tcaaatagat ggatttgtat caataccaaa tagcttctgt tttgttttgc tgaaggctaa     2220

attcacagcg ctatgcaatt cttaattttc attaagttgt tatttcagtt ttaaatgtac     2280

cttcagaata agcttcccca ccccagtttt tgttgcttga agatattgtt gtcccggatt     2340

tttgttaata ttcatttttg ttatcctttt ttaaaagtaa atgtacagga tgccagcaaa     2400

aaaaaaaaaa aaaaaaaaaa aaaaaaa                                         2427


<210> 9
<211> 1891
<212> DNA
<213> Homo sapiens

<400> 9
ccgcttcggg gaggaggacg ctgaggaggc gccgagccgc gcagcgctgc gggggaggcg       60

cccgcgccga cgcggggccc atggccagga ccaccagcca gctgtatgac gccgtgccca      120

tccagtccag cgtggtgtta tgttcctgcc catccccatc aatggtgagg acccagactg      180

agtccagcac gccccctggc attcctggtg gcagcaggca gggccccgcc atggacggca      240

ctgcagccga gcctcggccc ggcgccggct ccctgcagca tgcccagcct ccgccgcagc      300

ctcggaagaa gcggcctgag gacttcaagt ttgggaaaat ccttggggaa ggctcttttt      360

ccacggttgt cctggctcga gaactggcaa cctccagaga atatgcgatt aaaattctgg      420

agaagcgaca tatcataaaa gagaacaagg tcccctatgt aaccagagag cgggatgtca      480

tgtcgcgcct ggatcacccc ttctttgtta agctttactt cacatttcag gacgacgaga      540

agctgtattt cggccttagt tatgccaaaa atggagaact acttaaatat attcgcaaaa      600

tcggttcatt cgatgagacc tgtacccgat tttacacggc tgagatcgtg tctgctttag      660

agtacttgca cggcaagggc atcattcaca gggaccttaa accggaaaac attttgttaa      720

atgaagatat gcacatccag atcacagatt ttggaacagc aaaagtctta tccccagaga      780

gcaaacaagc cagggccaac tcattcgtgg gaacagcgca gtacgtttct ccagagctgc      840

tcacggagaa gtccgcctgt aagagttcag acctttgggc tcttggatgc ataatatacc      900

agcttgtggc aggactccca ccattccgag ctggaaacga gtatcttata tttcagaaga      960

tcattaagtt ggaatatgac tttccagaaa aattcttccc taaggcaaga gacctcgtgg     1020

agaaactttt ggttttagat gccacaaagc ggttaggctg tgaggaaatg gaaggatacg     1080

gacctcttaa agcacacccg ttcttcgagt ccgtcacgtg ggagaacctg caccagcaga     1140

cgcctccgaa gctcaccgct tacctgccgg ctatgtcgga agacgacgag gactgctatg     1200

gcaattatga caatctcctg agccagtttg gctgcatgca ggtgtcttcg tcctcctcct     1260

cacactccct gtcagcctcc gacacgggcc tgccccagag gtcaggcagc aacatagagc     1320

agtacattca cgatctggac tcgaactcct ttgaactgga cttacagttt tccgaagatg     1380

agaagaggtt gttgttggag aagcaggctg gcggaaaccc ttggcaccag tttgtagaaa     1440

ataatttaat actaaagatg ggcccagtgg ataagcggaa gggtttattt gcaagacgac     1500

gacagctgtt gctcacagaa ggaccacatt tatattatgt ggatcctgtc aacaaagttc     1560

tgaaaggtga aattccttgg tcacaagaac ttcgaccaga ggccaagaat tttaaaactt     1620

tctttgtcca cacgcctaac aggacgtatt atctgatgga ccccagcggg aacgcacaca     1680

agtggtgcag gaagatccag gaggtttgga ggcagcgata ccagagccac ccggacgccg     1740

ctgtgcagtg acgtggcctg cggccgggct gcccttcgct gccaggacac ctgccccagc     1800

gcggcttggc cgccatccgg gacgcttcca gaccacctgc cagccatcac aaggggaacg     1860

cagaggcgga aaccttgcag catttttatt t                                    1891


<210> 10
<211> 556
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser 
1               5                   10                  15      


Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln 
            20                  25                  30          


Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly 
        35                  40                  45              


Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser 
    50                  55                  60                  


Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu 
65                  70                  75                  80  


Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val 
                85                  90                  95      


Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile 
            100                 105                 110         


Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr 
        115                 120                 125             


Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys 
    130                 135                 140                 


Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser 
145                 150                 155                 160 


Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser 
                165                 170                 175     


Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala 
            180                 185                 190         


Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro 
        195                 200                 205             


Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe 
    210                 215                 220                 


Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn 
225                 230                 235                 240 


Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu 
                245                 250                 255     


Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile 
            260                 265                 270         


Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr 
        275                 280                 285             


Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys 
    290                 295                 300                 


Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp 
305                 310                 315                 320 


Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu 
                325                 330                 335     


Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln 
            340                 345                 350         


Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp 
        355                 360                 365             


Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly 
    370                 375                 380                 


Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser 
385                 390                 395                 400 


Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile 
                405                 410                 415     


His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu 
            420                 425                 430         


Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp 
        435                 440                 445             


His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp 
    450                 455                 460                 


Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu 
465                 470                 475                 480 


Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly 
                485                 490                 495     


Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys 
            500                 505                 510         


Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro 
        515                 520                 525             


Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg 
    530                 535                 540                 


Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln 
545                 550                 555     


<210> 11
<211> 5238
<212> DNA
<213> Homo sapiens

<400> 11
agtctggcag gcaggcaggc aatcggtccg agtggctgtc ggctcttcag ctctcccgct       60

cggcgtcttc cttcctcctc ccggtcagcg tcggcggctg caccggcggc ggcgcagtcc      120

ctgcgggagg ggcgacaaga gctgagcggc ggccgccgag cgtcgagctc agcgcggcgg      180

aggcggcggc ggcccggcag ccaacatggc ggcggcggcg gcggcgggcg cgggcccgga      240

gatggtccgc gggcaggtgt tcgacgtggg gccgcgctac accaacctct cgtacatcgg      300

cgagggcgcc tacggcatgg tgtgctctgc ttatgataat gtcaacaaag ttcgagtagc      360

tatcaagaaa atcagcccct ttgagcacca gacctactgc cagagaaccc tgagggagat      420

aaaaatctta ctgcgctcca gacatgagaa catcattgga atcaatgaca ttattcgagc      480

accaaccatc gagcaaatga aagatgtata tatagtacag gacctcatgg aaacagatct      540

ttacaagctc ttgaagacac aacacctcag caatgaccat atctgctatt ttctctacca      600

gatcctcaga gggttaaaat atatccattc agctaacgtt ctgcaccgtg acctcaagcc      660

ttccaacctg ctgctcaaca ccacctgtga tctcgagatc tgtgactttg gcctggcccg      720

tgttgcagat ccagaccatg atcacacagg gttcctgaca gaatatgtgg ccacacgttg      780

gtacagggct ccagaaatta tgttgaattc caagggctac accaagtcca ttgatatttg      840

gtctgtaggc tgcattctgg cagaaatgct ttctaacagg cccatctttc cagggaagca      900

ttatcttgac cagctgaacc acattttggg tattcttgga tccccatcac aagaagacct      960

gaattgtata ataaatttaa aagctaggaa ctatttgctt tctcttccac acaaaaataa     1020

ggtgccatgg aacaggctgt tcccaaatgc tgactccaaa gctctggact tattggacaa     1080

aatgttgaca ttcaacccac acaagaggat tgaagtagaa caggctctgg cccacccata     1140

tctggagcag tattacgacc cgagtgacga gcccatcgcc gaagcaccat tcaagttcga     1200

catggaattg gatgacttgc ctaaggaaaa gctcaaagaa ctaatttttg aagagactgc     1260

tagattccag ccaggataca gatcttaaat ttgtcaggac aagggctcag aggactggac     1320

gtgctcagac atcggtgttc ttcttcccag ttcttgaccc ctggtcctgt ctccagcccg     1380

tcttggctta tccactttga ctcctttgag ccgtttggag gggcggtttc tggtagttgt     1440

ggcttttatg ctttcaaaga atttcttcag tccagagaat tcctcctggc agccctgtgt     1500

gtgtcaccca ttggtgacct gcggcagtat gtacttcagt gcacctactg cttactgttg     1560

ctttagtcac taattgcttt ctggtttgaa agatgcagtg gttcctccct ctcctgaatc     1620

cttttctaca tgatgccctg ctgaccatgc agccgcacca gagagagatt cttccccaat     1680

tggctctagt cactggcatc tcactttatg atagggaagg ctactaccta gggcacttta     1740

agtcagtgac agccccttat ttgcacttca ccttttgacc ataactgttt ccccagagca     1800

ggagcttgtg gaaatacctt ggctgatgtt gcagcctgca gcaagtgctt ccgtctccgg     1860

aatccttggg gagcacttgt ccacgtcttt tctcatatca tggtagtcac taacatatat     1920

aaggtatgtg ctattggccc agcttttaga aaatgcagtc atttttctaa ataaaaagga     1980

agtactgcac ccagcagtgt cactctgtag ttactgtggt cacttgtacc atatagaggt     2040

gtaacacttg tcaagaagcg ttatgtgcag tacttaatgt ttgtaagact tacaaaaaaa     2100

gatttaaagt ggcagcttca ctcgacattt ggtgagagaa gtacaaaggt tgcagtgctg     2160

agctgtgggc ggtttctggg gatgtcccag ggtggaactc cacatgctgg tgcatatacg     2220

cccttgagct acttcaaatg tgggtgtttc agtaaccacg ttccatgcct gaggatttag     2280

cagagaggaa cactgcgtct ttaaatgaga aagtatacaa ttctttttcc ttctacagca     2340

tgtcagcatc tcaagttcat ttttcaacct acagtataac aatttgtaat aaagcctcca     2400

ggagctcatg acgtgaagca ctgttctgtc ctcaagtact caaatatttc tgatactgct     2460

gagtcagact gtcagaaaaa gctagcacta actcgtgttt ggagctctat ccatatttta     2520

ctgatctctt taagtatttg ttcctgccac tgtgtactgt ggagttgact cggtgttctg     2580

tcccagtgcg gtgcctcctc ttgacttccc cactgctctc tgtggtgaga aatttgcctt     2640

gttcaataat tactgtaccc tcgcatgact gttacagctt tctgtgcaga gatgactgtc     2700

caagtgccac atgcctacga ttgaaatgaa aactctattg ttacctctga gttgtgttcc     2760

acggaaaatg ctatccagca gatcatttag gaaaaataat tctattttta gcttttcatt     2820

tctcagctgt ccttttttct tgtttgattt ttgacagcaa tggagaatgg gttatataaa     2880

gactgcctgc taatatgaac agaaatgcat ttgtaattca tgaaaataaa tgtacatctt     2940

ctatcttcac attcatgtta agattcagtg ttgctttcct ctggatcagc gtgtctgaat     3000

ggacagtcag gttcaggttg tgctgaacac agaaatgctc acaggcctca ctttgccgcc     3060

caggcactgg cccagcactt ggatttacat aagatgagtt agaaaggtac ttctgtaggg     3120

tcctttttac ctctgctcgg cagagaatcg atgctgtcat gttcctttat tcacaatctt     3180

aggtctcaaa tattctgtca aaccctaaca aagaagcccc gacatctcag gttggattcc     3240

ctggttctct ataaagaggg cctgcccttg tgccccagag gtgctgctgg gcacagccaa     3300

gagttgggaa gggccgcccc acagtacgca gtcctcacca cccagcccag ggtgctcacg     3360

ctcaccactc ctgtggctga ggaaggatag ctggctcatc ctcggaaaac agacccacat     3420

ctctattctt gccctggaat acgcgctttt cacttgcgtg ctcagagctg ccgtctgaag     3480

gtccacacag cattgacggg acacagaaat gtgactgtta ccggataaca ctgattagtc     3540

agttttcatt tataaaaaag cattgacagt tttattactc ttgtttcttt ttaaatggaa     3600

agttactatt ataaggttaa tttggagtcc tcttctaaat agaaaaccat atccttggct     3660

actaacatct ggagactgtg agctccttcc cattcccctt cctggtactg tggagtcaga     3720

ttggcatgaa accactaact tcattctaga atcattgtag ccataagttg tgtgcttttt     3780

attaatcatg ccaaacataa tgtaactggg cagagaatgg tcctaaccaa ggtacctatg     3840

aaaagcgcta gctatcatgt gtagtagatg catcattttg gctcttctta catttgtaaa     3900

aatgtacaga ttaggtcatc ttaattcata ttagtgacac ggaacagcac ctccactatt     3960

tgtatgttca aataagcttt cagactaata gcttttttgg tgtctaaaat gtaagcaaaa     4020

aattcctgct gaaacattcc agtcctttca tttagtataa aagaaatact gaacaagcca     4080

gtgggatgga attgaaagaa ctaatcatga ggactctgtc ctgacacagg tcctcaaagc     4140

tagcagagat acgcagacat tgtggcatct gggtagaaga atactgtatt gtgtgtgcag     4200

tgcacagtgt gtggtgtgtg cacactcatt ccttctgctc ttgggcacag gcagtgggtg     4260

tagaggtaac cagtagcttt gagaagctac atgtagctca ccagtggttt tctctaagga     4320

atcacaaaag taaactaccc aaccacatgc cacgtaatat ttcagccatt cagaggaaac     4380

tgttttctct ttatttgctt atatgttaat atggttttta aattggtaac ttttatatag     4440

tatggtagca gtatgttaat acacacatac atacgcacac atgctttggg tccttccata     4500

atacttttat atttgtaaat caatgttttg gagcaatccc aagtttaagg gaaatatttt     4560

tgtaaatgta atggttttga aaatctgagc aatccttttg cttatacatt tttaaagcat     4620

ttgtgcttta aaattgttat gctggtgttt gaaacatgat actcctgtgg tgcagatgag     4680

aagctataac agtgaatatg tggtttctct tacgtcatcc accttgacat gatgggtcag     4740

aaacaaatgg aaatccagag caagtcctcc agggttgcac caggtttacc taaagcttgt     4800

tgccttttct tgtgctgttt atgcgtgtag agcactcaag aaagttctga aactgctttg     4860

tatctgcttt gtactgttgg tgccttcttg gtattgtacc ccaaaattct gcatagatta     4920

tttagtataa tggtaagtta aaaaatgtta aaggaagatt ttattaagaa tctgaatgtt     4980

tattcattat attgttacaa tttaacatta acatttattt gtggtatttg tgatttggtt     5040

aatctgtata aaaattgtaa gtagaaaggt ttatatttca tcttaattct tttgatgttg     5100

taaacgtact ttttaaaaga tggattattt gaatgtttat ggcacctgac ttgtaaaaaa     5160

aaaaaactac aaaaaaatcc ttagaatcat taaattgtgt ccctgtatta ccaaaataac     5220

acaaaaaaaa aaaaaaaa                                                   5238


<210> 12
<211> 360
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210> 13
<211> 1863
<212> DNA
<213> Homo sapiens

<400> 13
gcagactcag ttcctggaga aagatggcga cagccgagaa gcagaaacac gacgggcggg       60

tgaagatcgg ccactacatt ctgggtgaca cgctgggggt cggcaccttc ggcaaagtga      120

aggttggcaa acatgaattg actgggcata aagtagctgt gaagatactc aatcgacaga      180

agattcggag ccttgatgtg gtaggaaaaa tccgcagaga aattcagaac ctcaagcttt      240

tcaggcatcc tcatataatt aaactgtacc aggtcatcag tacaccatct gatattttca      300

tggtgatgga atatgtctca ggaggagagc tatttgatta tatctgtaag aatggaaggc      360

tggatgaaaa agaaagtcgg cgtctgttcc aacagatcct ttctggtgtg gattattgtc      420

acaggcatat ggtggtccat agagatttga aacctgaaaa tgtcctgctt gatgcacaca      480

tgaatgcaaa gatagctgat tttggtcttt caaacatgat gtcagatggt gaatttttaa      540

gaacaagttg tggctcaccc aactatgctg caccagaagt aatttcagga agattgtatg      600

caggcccaga ggtagatata tggagcagtg gggttattct ctatgcttta ttatgtggaa      660

cccttccatt tgatgatgac catgtgccaa ctctttttaa gaagatatgt gatgggatct      720

tctatacccc tcaatattta aatccttctg tgattagcct tttgaaacat atgctgcagg      780

tggatcccat gaagagggcc tcaatcaaag atatcaggga acatgaatgg tttaaacagg      840

accttccaaa atatctcttt cctgaggatc catcatatag ttcaaccatg attgatgatg      900

aagccttaaa agaagtatgt gaaaagtttg agtgctcaga agaggaagtt ctcagctgtc      960

tttacaacag aaatcaccag gatcctttgg cagttgccta ccatctcata atagataaca     1020

ggagaataat gaatgaagcc aaagatttct atttggcgac aagcccacct gattcttttc     1080

ttgatgatca tcacctgact cggccccatc ctgaaagagt accattcttg gttgctgaaa     1140

caccaagggc acgccatacc cttgatgaat taaatccaca gaaatccaaa caccaaggtg     1200

taaggaaagc aaaatggcat ttaggaatta gaagtcaaag tcgaccaaat gatattatgg     1260

cagaagtatg tagagcaatc aaacaattgg attatgaatg gaaggttgta aacccatatt     1320

atttgcgtgt acgaaggaag aatcctgtga caagcactta ctccaaaatg agtctacagt     1380

tataccaagt ggatagtaga acttatctac tggatttccg tagtattgat gatgaaatta     1440

cagaagccaa atcagggact gctactccac agagatcggg atcagttagc aactatcgat     1500

cttgccaaag gagtgattca gatgctgagg ctcaaggaaa atcctcagaa gtttctctta     1560

cctcatctgt gacctcactt gactcttctc ctgttgacct aactccaaga cctggaagtc     1620

acacaataga attttttgag atgtgtgcaa atctaattaa aattcttgca caataaacag     1680

aaaactttgc ttatttcttt tgcagcaata agcatgcata ataagtcaca gccaaatgct     1740

tccatttgta atcaagttat acataattat aaccgagggc tggcgttttg gaatcgaatt     1800

tcgacaggga ttggaacatg atttatagtt aaaagcctaa tatcgagaaa tgaattaaga     1860

tca                                                                   1863


<210> 14
<211> 559
<212> PRT
<213> Homo sapiens

<400> 14
Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr 
                85                  90                  95      


Pro Ser Asp Ile Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu 
            100                 105                 110         


Phe Asp Tyr Ile Cys Lys Asn Gly Arg Leu Asp Glu Lys Glu Ser Arg 
        115                 120                 125             


Arg Leu Phe Gln Gln Ile Leu Ser Gly Val Asp Tyr Cys His Arg His 
    130                 135                 140                 


Met Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala 
145                 150                 155                 160 


His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser 
                165                 170                 175     


Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala 
            180                 185                 190         


Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile 
        195                 200                 205             


Trp Ser Ser Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro 
    210                 215                 220                 


Phe Asp Asp Asp His Val Pro Thr Leu Phe Lys Lys Ile Cys Asp Gly 
225                 230                 235                 240 


Ile Phe Tyr Thr Pro Gln Tyr Leu Asn Pro Ser Val Ile Ser Leu Leu 
                245                 250                 255     


Lys His Met Leu Gln Val Asp Pro Met Lys Arg Ala Thr Ile Lys Asp 
            260                 265                 270         


Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu Pro Lys Tyr Leu Phe 
        275                 280                 285             


Pro Glu Asp Pro Ser Tyr Ser Ser Thr Met Ile Asp Asp Glu Ala Leu 
    290                 295                 300                 


Lys Glu Val Cys Glu Lys Phe Glu Cys Ser Glu Glu Glu Val Leu Ser 
305                 310                 315                 320 


Cys Leu Tyr Asn Arg Asn His Gln Asp Pro Leu Ala Val Ala Tyr His 
                325                 330                 335     


Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Glu Ala Lys Asp Phe Tyr 
            340                 345                 350         


Leu Ala Thr Ser Pro Pro Asp Ser Phe Leu Asp Asp His His Leu Thr 
        355                 360                 365             


Arg Pro His Pro Glu Arg Val Pro Phe Leu Val Ala Glu Thr Pro Arg 
    370                 375                 380                 


Ala Arg His Thr Leu Asp Glu Leu Asn Pro Gln Lys Ser Lys His Gln 
385                 390                 395                 400 


Gly Val Arg Lys Ala Lys Trp His Leu Gly Ile Arg Ser Gln Ser Arg 
                405                 410                 415     


Pro Asn Asp Ile Met Ala Glu Val Cys Arg Ala Ile Lys Gln Leu Asp 
            420                 425                 430         


Tyr Glu Trp Lys Val Val Asn Pro Tyr Tyr Leu Arg Val Arg Arg Lys 
        435                 440                 445             


Asn Pro Val Thr Ser Thr Tyr Ser Lys Met Ser Leu Gln Leu Tyr Gln 
    450                 455                 460                 


Val Asp Ser Arg Thr Tyr Leu Leu Asp Phe Arg Ser Ile Asp Asp Glu 
465                 470                 475                 480 


Ile Thr Glu Ala Lys Ser Gly Thr Ala Thr Pro Gln Arg Ser Gly Ser 
                485                 490                 495     


Val Ser Asn Tyr Arg Ser Cys Gln Arg Ser Asp Ser Asp Ala Glu Ala 
            500                 505                 510         


Gln Gly Lys Ser Ser Glu Val Ser Leu Thr Ser Ser Val Thr Ser Leu 
        515                 520                 525             


Asp Ser Ser Pro Val Asp Leu Thr Pro Arg Pro Gly Ser His Thr Ile 
    530                 535                 540                 


Glu Phe Phe Glu Met Cys Ala Asn Leu Ile Lys Ile Leu Ala Gln 
545                 550                 555                 


<210> 15
<211> 3919
<212> DNA
<213> Homo sapiens

<400> 15
ctttccctct cccaacatgg cggcctcagc aaaaaagaag aataagaagg ggaagactat       60

ctccctaaca gactttctgg ctgaggatgg gggtactggt ggaggaagca cctatgtttc      120

caaaccagtc agctgggctg atgaaacgga tgacctggaa ggagatgttt cgaccacttg      180

gcacagtaac gatgacgatg tgtatagggc gcctccaatt gaccgttcca tccttcccac      240

tgctccacgg gctgctcggg aacccaatat cgaccggagc cgtcttccca aatcgccacc      300

ctacactgct tttctaggaa acctacccta tgatgttaca gaagagtcaa ttaaggaatt      360

ctttcgagga ttaaatatca gtgcagtgcg tttaccacgt gaacccagca atccagagag      420

gttgaaaggt tttggttatg ctgaatttga ggacctggat tccctgctca gtgccctgag      480

tctcaatgaa gagtctctag gtaacaggag aattcgagtg gacgttgctg atcaagcaca      540

ggataaagac agggatgatc gttcttttgg ccgtgataga aatcgggatt ctgacaaaac      600

agatacagac tggagggctc gtcctgctac agacagcttt gatgactacc cacctagaag      660

aggtgatgat agctttggag acaagtatcg agatcgttat gattcagacc ggtatcggga      720

tgggtatcgg gatgggtatc gggatggccc acgccgggat atggatcgat atggtggccg      780

ggatcgctat gatgaccgag gcagcagaga ctatgataga ggctatgatt cccggatagg      840

cagtggcaga agagcatttg gcagtgggta tcgcagggat gatgactaca gaggaggcgg      900

ggaccgctat gaagaccgat atgacagacg ggatgatcgg tcgtggagct ccagagatga      960

ttactctcgg gatgattata ggcgtgatga tagaggtccc ccccaaagac ccaaactgaa     1020

tctaaagcct cggagtactc ctaaggaaga tgattcctct gctagtacct cccagtccac     1080

tcgagctgct tctatctttg gaggggcaaa gcctgttgac acagctgcta gagaaagaga     1140

agtagaagaa cggctacaga aggaacaaga gaagttgcag cgtcagctgg atgagccaaa     1200

actagaacga cggcctcggg agagacaccc aagctggcga agtgaagaaa ctcaggaacg     1260

ggaacggtcg aggacaggaa gtgagtcatc acaaactggg acctccacca catctagcag     1320

aaatgcacga aggagagaga gtgagaagtc tctagaaaat gaaacactca ataaggagga     1380

agattgccac tctccaactt ctaaacctcc caaacctgat cagcccctaa aggtaatgcc     1440

agcccctcca ccaaaggaga atgcttgggt gaagcgaagt tctaaccctc ctgctcgatc     1500

tcagagctca gacacagagc agcagtcccc tacaagtggt gggggaaaag tagctccagc     1560

tcaaccatct gaggaaggac caggaaggaa agatgaaaat aaagtagatg ggatgaatgc     1620

cccaaaaggc caaactggga actctagccg tggtccagga gacggaggga acagagacca     1680

ctggaaggag tcagatagga aagatggcaa aaaggatcaa gactccagat ctgcacctga     1740

gccaaagaaa cctgaggaaa atccagcttc taagttcagt tctgcaagca agtatgctgc     1800

tctctctgtt gatggtgaag atgaaaatga gggagaagat tatgccgaat agacctctac     1860

atcctgtgct tttctcctag tttctctcca ccctggaaca ttcgagagca aatcaaaacc     1920

tctatccaga caagacaaaa taaaactcaa catctcctga agacctttct tacctttttt     1980

taaaaacaaa aaatgaaatt attttgcatg ctgctgcagc ctttaaagta ttgaagtaac     2040

tggagaattg ccaatacagc cagagagaaa gggactacag ctttttagag gaaaagttgt     2100

ggtgcgttat gtcaccatgc agttgccagt gtgattagtg cctaggggtc tccatttagc     2160

agaaatggta atgacagtga tataatgcct ggaacctggt tgggcagtag gggagggagg     2220

tagaaggaaa agtgtgagat ttctaccttt tagtttttat cctattgtgg catatatgaa     2280

ttctcaaaca ttatctgaat aaattttcca ctcttggaaa ggtagattta gcctcaagtt     2340

gttctagtct ccaggaggct gccagcccct cctcttattt aattctgagt tttgggggcc     2400

agcctagagg gaatcccttt ttttttttaa ccccccaggg gggtagttgg gagtgagact     2460

ataggccata aagaatggga ctgcattgga ccaaaataaa tgggaaaatc gtggtttgaa     2520

aagaagcttt tgggaagtga tgagtcattt tgcaccaggt aataggggaa aattgtgtga     2580

cctccagcaa acacatgaat ggttatttcc tggagccgga agcacttggg ggtcgtggta     2640

attcccagtg ttttctgtgt cctagtttta ccctttctaa acactgtcct ttttgaaagt     2700

tttgaatata tccacattct attgaaacct tgaaactaaa aatttagact cttatcgtca     2760

tcttaagttc ttcatggtac tcttaacctc ccaaaaagca gtatctaagt cacatacatg     2820

atgtcttggg cattttctga gccatggaga actctgaaag gaagaatcgc tgcttttctc     2880

aagcaaatcg gtttcttgat gtcttttggt tctccttgcc tgctcctgat gcttggaccc     2940

cttttattga tcagagtgct ctagaataat ggatggtctt ggatgatgga taaataggga     3000

cagggacagt taaattggga gcctttctta caaccttgat gggatttttc cccccaagtt     3060

tccttctcca ctgaaatgcc acactaatgc ttgttggatt catgaggtgg ccagaccaat     3120

gtgttgtttt gttgttgttt ttttttttta agcttccctt gagagaataa atggtaatgg     3180

agagaactat ttaacaaggt cctggtttct cttgcaacac agtagctaaa cttgcctgct     3240

tttatatgca tttttgtagg gatcagcttg gtagacagta ttagcggaga aacaccttga     3300

tcttggtttg caagcccttc tcccatcagt cctagattag gccctgttca gccatgcagg     3360

ggtgttggtt tatgcgtgct gcagcagtgg gcataatgaa tataatttac ccagtggaca     3420

aaggtgtgta ccaagtgaat ttaaataatt ggtgtggatt ggccagtagc taagtgggct     3480

tttaaagagt attgaagatt gaaagggttt ttctttcttt tttaaaaaag aaaaacaaac     3540

tattgattgt agataatgaa aagctagggt ttgccctctt catgtctact ctccttccaa     3600

atagttatat ccaaaactgt ttttccctct cccctacctt gtccccccta ttaaaataga     3660

aacagggatt gattaatgtc ccgctcctga atacatgtaa aatttgtaca aaaatatctt     3720

ctatgaaaat gatttgtaat ctgtagactt attacctggg agatgtcttg atgtaaaatc     3780

ccatcctttg ggttgtgggt tttttgtttt ctccaaataa atctgatctt taaagttcaa     3840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3900

aaaaaaaaaa aaaaaaaaa                                                  3919


<210> 16
<211> 611
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Ala Ser Ala Lys Lys Lys Asn Lys Lys Gly Lys Thr Ile Ser 
1               5                   10                  15      


Leu Thr Asp Phe Leu Ala Glu Asp Gly Gly Thr Gly Gly Gly Ser Thr 
            20                  25                  30          


Tyr Val Ser Lys Pro Val Ser Trp Ala Asp Glu Thr Asp Asp Leu Glu 
        35                  40                  45              


Gly Asp Val Ser Thr Thr Trp His Ser Asn Asp Asp Asp Val Tyr Arg 
    50                  55                  60                  


Ala Pro Pro Ile Asp Arg Ser Ile Leu Pro Thr Ala Pro Arg Ala Ala 
65                  70                  75                  80  


Arg Glu Pro Asn Ile Asp Arg Ser Arg Leu Pro Lys Ser Pro Pro Tyr 
                85                  90                  95      


Thr Ala Phe Leu Gly Asn Leu Pro Tyr Asp Val Thr Glu Glu Ser Ile 
            100                 105                 110         


Lys Glu Phe Phe Arg Gly Leu Asn Ile Ser Ala Val Arg Leu Pro Arg 
        115                 120                 125             


Glu Pro Ser Asn Pro Glu Arg Leu Lys Gly Phe Gly Tyr Ala Glu Phe 
    130                 135                 140                 


Glu Asp Leu Asp Ser Leu Leu Ser Ala Leu Ser Leu Asn Glu Glu Ser 
145                 150                 155                 160 


Leu Gly Asn Arg Arg Ile Arg Val Asp Val Ala Asp Gln Ala Gln Asp 
                165                 170                 175     


Lys Asp Arg Asp Asp Arg Ser Phe Gly Arg Asp Arg Asn Arg Asp Ser 
            180                 185                 190         


Asp Lys Thr Asp Thr Asp Trp Arg Ala Arg Pro Ala Thr Asp Ser Phe 
        195                 200                 205             


Asp Asp Tyr Pro Pro Arg Arg Gly Asp Asp Ser Phe Gly Asp Lys Tyr 
    210                 215                 220                 


Arg Asp Arg Tyr Asp Ser Asp Arg Tyr Arg Asp Gly Tyr Arg Asp Gly 
225                 230                 235                 240 


Tyr Arg Asp Gly Pro Arg Arg Asp Met Asp Arg Tyr Gly Gly Arg Asp 
                245                 250                 255     


Arg Tyr Asp Asp Arg Gly Ser Arg Asp Tyr Asp Arg Gly Tyr Asp Ser 
            260                 265                 270         


Arg Ile Gly Ser Gly Arg Arg Ala Phe Gly Ser Gly Tyr Arg Arg Asp 
        275                 280                 285             


Asp Asp Tyr Arg Gly Gly Gly Asp Arg Tyr Glu Asp Arg Tyr Asp Arg 
    290                 295                 300                 


Arg Asp Asp Arg Ser Trp Ser Ser Arg Asp Asp Tyr Ser Arg Asp Asp 
305                 310                 315                 320 


Tyr Arg Arg Asp Asp Arg Gly Pro Pro Gln Arg Pro Lys Leu Asn Leu 
                325                 330                 335     


Lys Pro Arg Ser Thr Pro Lys Glu Asp Asp Ser Ser Ala Ser Thr Ser 
            340                 345                 350         


Gln Ser Thr Arg Ala Ala Ser Ile Phe Gly Gly Ala Lys Pro Val Asp 
        355                 360                 365             


Thr Ala Ala Arg Glu Arg Glu Val Glu Glu Arg Leu Gln Lys Glu Gln 
    370                 375                 380                 


Glu Lys Leu Gln Arg Gln Leu Asp Glu Pro Lys Leu Glu Arg Arg Pro 
385                 390                 395                 400 


Arg Glu Arg His Pro Ser Trp Arg Ser Glu Glu Thr Gln Glu Arg Glu 
                405                 410                 415     


Arg Ser Arg Thr Gly Ser Glu Ser Ser Gln Thr Gly Thr Ser Thr Thr 
            420                 425                 430         


Ser Ser Arg Asn Ala Arg Arg Arg Glu Ser Glu Lys Ser Leu Glu Asn 
        435                 440                 445             


Glu Thr Leu Asn Lys Glu Glu Asp Cys His Ser Pro Thr Ser Lys Pro 
    450                 455                 460                 


Pro Lys Pro Asp Gln Pro Leu Lys Val Met Pro Ala Pro Pro Pro Lys 
465                 470                 475                 480 


Glu Asn Ala Trp Val Lys Arg Ser Ser Asn Pro Pro Ala Arg Ser Gln 
                485                 490                 495     


Ser Ser Asp Thr Glu Gln Gln Ser Pro Thr Ser Gly Gly Gly Lys Val 
            500                 505                 510         


Ala Pro Ala Gln Pro Ser Glu Glu Gly Pro Gly Arg Lys Asp Glu Asn 
        515                 520                 525             


Lys Val Asp Gly Met Asn Ala Pro Lys Gly Gln Thr Gly Asn Ser Ser 
    530                 535                 540                 


Arg Gly Pro Gly Asp Gly Gly Asn Arg Asp His Trp Lys Glu Ser Asp 
545                 550                 555                 560 


Arg Lys Asp Gly Lys Lys Asp Gln Asp Ser Arg Ser Ala Pro Glu Pro 
                565                 570                 575     


Lys Lys Pro Glu Glu Asn Pro Ala Ser Lys Phe Ser Ser Ala Ser Lys 
            580                 585                 590         


Tyr Ala Ala Leu Ser Val Asp Gly Glu Asp Glu Asn Glu Gly Glu Asp 
        595                 600                 605             


Tyr Ala Glu 
    610     


<210> 17
<211> 877
<212> DNA
<213> Homo sapiens

<400> 17
ggggcgaggc ggagcgaggc tggaggcgcg ggagggcagc gagaggttcg cgggtgcagc       60

gcacaggaga ccatgtccgg gggcagcagc tgcagccaga ccccaagccg ggccatcccc      120

gccactcgcc gggtggtgct cggcgacggc gtgcagctcc cgcccgggga ctacagcacg      180

acccccggcg gcacgctctt cagcaccacc ccgggaggta ccaggatcat ctatgaccgg      240

aaattcctga tggagtgtcg gaactcacct gtgaccaaaa cacccccaag ggatctgccc      300

accattccgg gggtcaccag cccttccagt gatgagcccc ccatggaagc cagccagagc      360

cacctgcgca atagcccaga agataagcgg gcgggcggtg aagagtcaca gtttgagatg      420

gacatttaaa gcaccagcca tcgtgtggag cactaccaag gggcccctca gggccttcct      480

gggaggagtc ccaccagcca ggccttatga aagtgatcat actgggcagg cgttggcgtg      540

gggtcggaca ccccagccct ttctccctca ctcagggcac ctgccccctc ctcttcgtga      600

acaccagcag atacctcctt gtgcctccac tgatgcagga gctgccaccc caaggggagt      660

gacccctgcc agcacaccct gcagccaagg gccaggaagt ggacaagaac gaacccttcc      720

ttccgaatga tcagcagttc cagcccctcg ctgctggggg cgcaaccacc ccttccttag      780

gttgatgtgc ttgggaaagc tccctccccc tccttcccca agagaggaaa taaaagccac      840

cttcgcccta gggccaagaa aaaaaaaaaa aaaaaaa                               877


<210> 18
<211> 118
<212> PRT
<213> Homo sapiens

<400> 18
Met Ser Gly Gly Ser Ser Cys Ser Gln Thr Pro Ser Arg Ala Ile Pro 
1               5                   10                  15      


Ala Thr Arg Arg Val Val Leu Gly Asp Gly Val Gln Leu Pro Pro Gly 
            20                  25                  30          


Asp Tyr Ser Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly 
        35                  40                  45              


Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Met Glu Cys Arg Asn 
    50                  55                  60                  


Ser Pro Val Thr Lys Thr Pro Pro Arg Asp Leu Pro Thr Ile Pro Gly 
65                  70                  75                  80  


Val Thr Ser Pro Ser Ser Asp Glu Pro Pro Met Glu Ala Ser Gln Ser 
                85                  90                  95      


His Leu Arg Asn Ser Pro Glu Asp Lys Arg Ala Gly Gly Glu Glu Ser 
            100                 105                 110         


Gln Phe Glu Met Asp Ile 
        115             


<210> 19
<211> 8733
<212> DNA
<213> Homo sapiens

<400> 19
gctcccggct tagaggacag cggggaaggc gggcggtggg gcagggggcc tgaagcggcg       60

gtaccggtgc tggcggcggc agctgaggcc ttggccgaag ccgcgcgaac ctcagggcaa      120

gatgcttgga accggacctg ccgccgccac caccgctgcc accacatcta gcaatgtgag      180

cgtcctgcag cagtttgcca gtggcctaaa gagccggaat gaggaaacca gggccaaagc      240

cgccaaggag ctccagcact atgtcaccat ggaactccga gagatgagtc aagaggagtc      300

tactcgcttc tatgaccaac tgaaccatca catttttgaa ttggtttcca gctcagatgc      360

caatgagagg aaaggtggca tcttggccat agctagcctc ataggagtgg aaggtgggaa      420

tgccacccga attggcagat ttgccaacta tcttcggaac ctcctcccct ccaatgaccc      480

agttgtcatg gaaatggcat ccaaggccat tggccgtctt gccatggcag gggacacttt      540

taccgctgag tacgtggaat ttgaggtgaa gcgagccctg gaatggctgg gtgctgaccg      600

caatgagggc cggagacatg cagctgtcct ggttctccgt gagctggcca tcagcgtccc      660

taccttcttc ttccagcaag tgcaaccctt ctttgacaac atttttgtgg ccgtgtggga      720

ccccaaacag gccatccgtg agggagctgt agccgccctt cgtgcctgtc tgattctcac      780

aacccagcgt gagccgaagg agatgcagaa gcctcagtgg tacaggcaca catttgaaga      840

agcagagaag ggatttgatg agaccttggc caaagagaag ggcatgaatc gggatgatcg      900

gatccatgga gccttgttga tccttaacga gctggtccga atcagcagca tggagggaga      960

gcgtctgaga gaagaaatgg aagaaatcac acagcagcag ctggtacacg acaagtactg     1020

caaagatctc atgggcttcg gaacaaaacc tcgtcacatt acccccttca ccagtttcca     1080

ggctgtacag ccccagcagt caaatgcctt ggtggggctg ctggggtaca gctctcacca     1140

aggcctcatg ggatttggga cctcccccag tccagctaag tccaccctgg tggagagccg     1200

gtgttgcaga gacttgatgg aggagaaatt tgatcaggtg tgccagtggg tgctgaaatg     1260

caggaatagc aagaactcgc tgatccaaat gacaatcctt aatttgttgc cccgcttggc     1320

tgcattccga ccttctgcct tcacagatac ccagtatctc caagatacca tgaaccatgt     1380

cctaagctgt gtcaagaagg agaaggaacg tacagcggcc ttccaagccc tggggctact     1440

ttctgtggct gtgaggtctg agtttaaggt ctatttgcct cgcgtgctgg acatcatccg     1500

agcggccctg cccccaaagg acttcgccca taagaggcag aaggcaatgc aggtggatgc     1560

cacagtcttc acttgcatca gcatgctggc tcgagcaatg gggccaggca tccagcagga     1620

tatcaaggag ctgctggagc ccatgctggc agtgggacta agccctgccc tcactgcagt     1680

gctctacgac ctgagccgtc agattccaca gctaaagaag gacattcaag atgggctact     1740

gaaaatgctg tccctggtcc ttatgcacaa accccttcgc cacccaggca tgcccaaggg     1800

cctggcccat cagctggcct ctcctggcct cacgaccctc cctgaggcca gcgatgtggg     1860

cagcatcact cttgccctcc gaacgcttgg cagctttgaa tttgaaggcc actctctgac     1920

ccaatttgtt cgccactgtg cggatcattt cctgaacagt gagcacaagg agatccgcat     1980

ggaggctgcc cgcacctgct cccgcctgct cacaccctcc atccacctca tcagtggcca     2040

tgctcatgtg gttagccaga ccgcagtgca agtggtggca gatgtgctta gcaaactgct     2100

cgtagttggg ataacagatc ctgaccctga cattcgctac tgtgtcttgg cgtccctgga     2160

cgagcgcttt gatgcacacc tggcccaggc ggagaacttg caggccttgt ttgtggctct     2220

gaatgaccag gtgtttgaga tccgggagct ggccatctgc actgtgggcc gactcagtag     2280

catgaaccct gcctttgtca tgcctttcct gcgcaagatg ctcatccaga ttttgacaga     2340

gttggagcac agtgggattg gaagaatcaa agagcagagt gcccgcatgc tggggcacct     2400

ggtctccaat gccccccgac tcatccgccc ctacatggag cctattctga aggcattaat     2460

tttgaaactg aaagatccag accctgatcc aaacccaggt gtgatcaata atgtcctggc     2520

aacaatagga gaattggcac aggttagtgg cctggaaatg aggaaatggg ttgatgaact     2580

ttttattatc atcatggaca tgctccagga ttcctctttg ttggccaaaa ggcaggtggc     2640

tctgtggacc ctgggacagt tggtggccag cactggctat gtagtagagc cctacaggaa     2700

gtaccctact ttgcttgagg tgctactgaa ttttctgaag actgagcaga accagggtac     2760

acgcagagag gccatccgtg tgttagggct tttaggggct ttggatcctt acaagcacaa     2820

agtgaacatt ggcatgatag accagtcccg ggatgcctct gctgtcagcc tgtcagaatc     2880

caagtcaagt caggattcct ctgactatag cactagtgaa atgctggtca acatgggaaa     2940

cttgcctctg gatgagttct acccagctgt gtccatggtg gccctgatgc ggatcttccg     3000

agaccagtca ctctctcatc atcacaccat ggttgtccag gccatcacct tcatcttcaa     3060

gtccctggga ctcaaatgtg tgcagttcct gccccaggtc atgcccacgt tccttaacgt     3120

cattcgagtc tgtgatgggg ccatccggga atttttgttc cagcagctgg gaatgttggt     3180

gtcctttgtg aagagccaca tcagacctta tatggatgaa atagtcaccc tcatgagaga     3240

attctgggtc atgaacacct caattcagag cacgatcatt cttctcattg agcaaattgt     3300

ggtagctctt gggggtgaat ttaagctcta cctgccccag ctgatcccac acatgctgcg     3360

tgtcttcatg catgacaaca gcccaggccg cattgtctct atcaagttac tggctgcaat     3420

ccagctgttt ggcgccaacc tggatgacta cctgcattta ctgctgcctc ctattgttaa     3480

gttgtttgat gcccctgaag ctccactgcc atctcgaaag gcagcgctag agactgtgga     3540

ccgcctgacg gagtccctgg atttcactga ctatgcctcc cggatcattc accctattgt     3600

tcgaacactg gaccagagcc cagaactgcg ctccacagcc atggacacgc tgtcttcact     3660

tgtttttcag ctggggaaga agtaccaaat tttcattcca atggtgaata aagttctggt     3720

gcgacaccga atcaatcatc agcgctatga tgtgctcatc tgcagaattg tcaagggata     3780

cacacttgct gatgaagagg aggatccttt gatttaccag catcggatgc ttaggagtgg     3840

ccaaggggat gcattggcta gtggaccagt ggaaacagga cccatgaaga aactgcacgt     3900

cagcaccatc aacctccaaa aggcctgggg cgctgccagg agggtctcca aagatgactg     3960

gctggaatgg ctgagacggc tgagcctgga gctgctgaag gactcatcat cgccctccct     4020

gcgctcctgc tgggccctgg cacaggccta caacccgatg gccagggatc tcttcaatgc     4080

tgcatttgtg tcctgctggt ctgaactgaa tgaagatcaa caggatgagc tcatcagaag     4140

catcgagttg gccctcacct cacaagacat cgctgaagtc acacagaccc tcttaaactt     4200

ggctgaattc atggaacaca gtgacaaggg ccccctgcca ctgagagatg acaatggcat     4260

tgttctgctg ggtgagagag ctgccaagtg ccgagcatat gccaaagcac tacactacaa     4320

agaactggag ttccagaaag gccccacccc tgccattcta gaatctctca tcagcattaa     4380

taataagcta cagcagccgg aggcagcggc cggagtgtta gaatatgcca tgaaacactt     4440

tggagagctg gagatccagg ctacctggta tgagaaactg cacgagtggg aggatgccct     4500

tgtggcctat gacaagaaaa tggacaccaa caaggacgac ccagagctga tgctgggccg     4560

catgcgctgc ctcgaggcct tgggggaatg gggtcaactc caccagcagt gctgtgaaaa     4620

gtggaccctg gttaatgatg agacccaagc caagatggcc cggatggctg ctgcagctgc     4680

atggggttta ggtcagtggg acagcatgga agaatacacc tgtatgatcc ctcgggacac     4740

ccatgatggg gcattttata gagctgtgct ggcactgcat caggacctct tctccttggc     4800

acaacagtgc attgacaagg ccagggacct gctggatgct gaattaactg cgatggcagg     4860

agagagttac agtcgggcat atggggccat ggtttcttgc cacatgctgt ccgagctgga     4920

ggaggttatc cagtacaaac ttgtccccga gcgacgagag atcatccgcc agatctggtg     4980

ggagagactg cagggctgcc agcgtatcgt agaggactgg cagaaaatcc ttatggtgcg     5040

gtcccttgtg gtcagccctc atgaagacat gagaacctgg ctcaagtatg caagcctgtg     5100

cggcaagagt ggcaggctgg ctcttgctca taaaacttta gtgttgctcc tgggagttga     5160

tccgtctcgg caacttgacc atcctctgcc aacagttcac cctcaggtga cctatgccta     5220

catgaaaaac atgtggaaga gtgcccgcaa gatcgatgcc ttccagcaca tgcagcattt     5280

tgtccagacc atgcagcaac aggcccagca tgccatcgct actgaggacc agcagcataa     5340

gcaggaactg cacaagctca tggcccgatg cttcctgaaa cttggagagt ggcagctgaa     5400

tctacagggc atcaatgaga gcacaatccc caaagtgctg cagtactaca gcgccgccac     5460

agagcacgac cgcagctggt acaaggcctg gcatgcgtgg gcagtgatga acttcgaagc     5520

tgtgctacac tacaaacatc agaaccaagc ccgcgatgag aagaagaaac tgcgtcatgc     5580

cagcggggcc aacatcacca acgccaccac tgccgccacc acggccgcca ctgccaccac     5640

cactgccagc accgagggca gcaacagtga gagcgaggcc gagagcaccg agaacagccc     5700

caccccatcg ccgctgcaga agaaggtcac tgaggatctg tccaaaaccc tcctgatgta     5760

cacggtgcct gccgtccagg gcttcttccg ttccatctcc ttgtcacgag gcaacaacct     5820

ccaggataca ctcagagttc tcaccttatg gtttgattat ggtcactggc cagatgtcaa     5880

tgaggcctta gtggaggggg tgaaagccat ccagattgat acctggctac aggttatacc     5940

tcagctcatt gcaagaattg atacgcccag acccttggtg ggacgtctca ttcaccagct     6000

tctcacagac attggtcggt accaccccca ggccctcatc tacccactga cagtggcttc     6060

taagtctacc acgacagccc ggcacaatgc agccaacaag attctgaaga acatgtgtga     6120

gcacagcaac accctggtcc agcaggccat gatggtgagc gaggagctga tccgagtggc     6180

catcctctgg catgagatgt ggcatgaagg cctggaagag gcatctcgtt tgtactttgg     6240

ggaaaggaac gtgaaaggca tgtttgaggt gctggagccc ttgcatgcta tgatggaacg     6300

gggcccccag actctgaagg aaacatcctt taatcaggcc tatggtcgag atttaatgga     6360

ggcccaagag tggtgcagga agtacatgaa atcagggaat gtcaaggacc tcacccaagc     6420

ctgggacctc tattatcatg tgttccgacg aatctcaaag cagctgcctc agctcacatc     6480

cttagagctg caatatgttt ccccaaaact tctgatgtgc cgggaccttg aattggctgt     6540

gccaggaaca tatgacccca accagccaat cattcgcatt cagtccatag caccgtcttt     6600

gcaagtcatc acatccaagc agaggccccg gaaattgaca cttatgggca gcaacggaca     6660

tgagtttgtt ttccttctaa aaggccatga agatctgcgc caggatgagc gtgtgatgca     6720

gctcttcggc ctggttaaca cccttctggc caatgaccca acatctcttc ggaaaaacct     6780

cagcatccag agatacgctg tcatcccttt atcgaccaac tcgggcctca ttggctgggt     6840

tccccactgt gacacactgc acgccctcat ccgggactac agggagaaga agaagatcct     6900

tctcaacatc gagcatcgca tcatgttgcg gatggctccg gactatgacc acttgactct     6960

gatgcagaag gtggaggtgt ttgagcatgc cgtcaataat acagctgggg acgacctggc     7020

caagctgctg tggctgaaaa gccccagctc cgaggtgtgg tttgaccgaa gaaccaatta     7080

tacccgttct ttagcggtca tgtcaatggt tgggtatatt ttaggcctgg gagatagaca     7140

cccatccaac ctgatgctgg accgtctgag tgggaagatc ctgcacattg actttgggga     7200

ctgctttgag gttgctatga cccgagagaa gtttccagag aagattccat ttagactaac     7260

aagaatgttg accaatgcta tggaggttac aggcctggat ggcaactaca gaatcacatg     7320

ccacacagtg atggaggtgc tgcgagagca caaggacagt gtcatggccg tgctggaagc     7380

ctttgtctat gaccccttgc tgaactggag gctgatggac acaaatacca aaggcaacaa     7440

gcgatcccga acgaggacgg attcctactc tgctggccag tcagtcgaaa ttttggacgg     7500

tgtggaactt ggagagccag cccataagaa aacggggacc acagtgccag aatctattca     7560

ttctttcatt ggagacggtt tggtgaaacc agaggcccta aataagaaag ctatccagat     7620

tattaacagg gttcgagata agctcactgg tcgggacttc tctcatgatg acactttgga     7680

tgttccaacg caagttgagc tgctcatcaa acaagcgaca tcccatgaaa acctctgcca     7740

gtgctatatt ggctggtgcc ctttctggta actggaggcc cagatgtgcc catcacgttt     7800

tttctgaggc ttttgtactt tagtaaatgc ttccactaaa ctgaaaccat ggtgagaaag     7860

tttgactttg ttaaatattt tgaaatgtaa atgaaaagaa ctactgtata ttaaaagttg     7920

gtttgaacca actttctagc tgctgttgaa gaatatattg tcagaaacac aaggcttgat     7980

ttggttccca ggacagtgaa acatagtaat accacgtaaa tcaagccatt cattttgggg     8040

aacagaagat ccataacttt agaaatacgg gttttgactt aactcacaag agaactcatc     8100

ataagtactt gctgatggaa gaatgaccta gttgctcctc tcaacatggg tacagcaaac     8160

tcagcacagc caagaagcct caggtcgtgg agaacatgga ttaggatcct agactgtaaa     8220

gacacagaag atgctgacct cacccctgcc acctatccca agacctcact ggtctgtgga     8280

cagcagcaga aatgtttgca agataggcca aaatgagtac aaaaggtctg tcttccatca     8340

gacccagtga tgctgcgact cacacgcttc aattcaagac ctgaccgcta gtagggaggt     8400

ttattcagat cgctggcagc ctcggctgag cagatgcaca gaggggatca ctgtgcagtg     8460

ggaccaccct cactggcctt ctgcagcagg gttctgggat gttttcagtg gtcaaaatac     8520

tctgtttaga gcaagggctc agaaaacaga aatactgtca tggaggtgct gaacacaggg     8580

aaggtctggt acatattgga aattatgagc agaacaaata ctcaactaaa tgcacaaagt     8640

ataaagtgta gccatgtcta gacaccatgt tgtatcagaa taatttttgt gccaataaat     8700

gacatcagaa ttttaaacat atgtaaaaaa aaa                                  8733


<210> 20
<211> 2549
<212> PRT
<213> Homo sapiens

<400> 20
Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210> 21
<211> 2344
<212> DNA
<213> Homo sapiens

<400> 21
gacagctgga agagccgaac ggataagaga agaggaggtg agaggagctg tacaccacaa       60

gaggcactga gggactcagg ataacgggat gaagccgtca gtgcccccag aaacgaagcg      120

gccccggacg aatttctgag tcaccgtcgc gagaaagcgg gctgagccgc cattttgaag      180

cctggcaaac cgaagcaaga aatgctgccg tgttggatct ttgccagcct tcgtgccgaa      240

tgggagcagg ttggagggag ggagagccaa tatacactat gggctgatta agcccggttg      300

gctgccatgt tgttaacgag caccgatttc ctctactttt gtcgaagaag tttattgtgg      360

gtcagggacg tcaggtcgct tgccttcgtt tactgtggtc atgattgagc atatgaggac      420

ggccattatt gttgggggca aatggaaatg ctctaggcgg ggccattttt cttaggggca      480

agctgtcgtc acccttgtca actggttcgg atgaagcccc tgtggccgcc atcttgatct      540

cgggcggccc cgataaggga ggcggagtgt gcggagagga ggcggggcaa ctgcgcggac      600

gtgacgcaag gcgccgccat gtcttttgag ggcggtgacg gcgccgggcc ggccatgctg      660

gctacgggca cggcgcggat ggcgtcgggg cgccccgagg agctgtggga ggccgtggtg      720

ggggccgctg agcgcttccg ggcccggact ggcacggagc tggtgctgct gaccgcggcc      780

ccgccgccac caccccgccc gggcccctgt gcctatcctg cccatggtcg aggagccctg      840

gcggaggcag cgcgccgttg cctccacgac atcgcactgg cccacagggc tgccactgct      900

gctcggcctc ctgcgccccc accagcacca cagccaccca gtcccacacc cagcccaccc      960

cggcctaccc tggccagaga ggacaacgag gaggacgagg atgagcccac agagacagag     1020

acctccgggg agcagctggg cattagtgat aatggagggc tctttgtgat ggatgaggac     1080

gccaccctcc aggaccttcc ccccttctgt gagtcagacc ccgagagtac agatgatggc     1140

agcctgagcg aggagacccc cgccggcccc cccacctgct cagtgccccc agcctcagcc     1200

ctacccacac agcagtacgc caagtccctg cctgtgtctg tgcccgtctg gggcttcaag     1260

gagaagagga cagaggcgcg gtcatcagat gaggagaatg ggccgccctc ttcgcccgac     1320

ctggaccgca tcgcggcgag catgcgcgcg ctggtgctgc gagaggccga ggacacccag     1380

gtcttcgggg acctgccacg gccgcggctt aacaccagcg acttccagaa gctgaagcgg     1440

aaatattgaa gtccagggag ggagcgcccc gggccgcgtc cgccccgtcc cacactacgc     1500

ccccgcccca ctcccggggc ctgctaatct gaggccgatc cgggaccggc ctccttgcgt     1560

ctcccattcc caagattgtc ccgcctctgc caatccccgc cgtccttcca gcccacgacc     1620

tgccgcgccg aggagcggca tctgtcccgt ttcccgattg ggtctgtcgt ctctctccgc     1680

ctagcgacag attccttcta ttaagggatt ggctcgctga gttctaagct ctaaatgggt     1740

caactccttt gttttccgcc tagcgacaag ggatttgctc gcacggcatt ggctccatcc     1800

cctagtcgct ggacagctct ttttttgatt ggctcaaatc ctgtaaaggg cttgaccagt     1860

ctctacatag tcaccgtccg cttttcctga gttctccctc ccaattggct ccagcttcct     1920

gggggcgtgg ccaagccctc ctcttcccag aattggcccg gggccttcaa tttacgttct     1980

ttacactacg gggactgggg tcgtctttgc ccacgtcccg acaacttgtt ccctgacccc     2040

ctcagggatg gccccaaact gtccctgcct ctggcacccc ctttcattgg ttccatccat     2100

ccccacaaca gcctgccaat cgaagcccgt ccctgcatcc aggatggtac cagctcccgc     2160

ccctcgcccc ccacctccac aggtgcctta aagggccctc gtccacccaa ggtggggggc     2220

aggggccctc actctccggc cctggtgtgg gggagagagt gaggggttgg gggatcggca     2280

gttgggaggg gcgctctgag attaaagagt tttacctctg agataaaaaa aaaaaaaaaa     2340

aaaa                                                                  2344


<210> 22
<211> 256
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Thr Glu 
            100                 105                 110         


Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu Ser Glu Glu Thr 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210> 23
<211> 1964
<212> DNA
<213> Homo sapiens

<400> 23
agacgcactg agcctaagca gccggtgatg gcggcagcgg ctgtggtggc tgcggcgggt       60

ccgggcccat gaggcgacga aggaggcggg acggctttta cccagccccg gacttccgag      120

acagggaagc tgaggacatg gcaggagtgt ttgacataga cctggaccag ccagaggacg      180

cgggctctga ggatgagctg gaggaggggg gtcagttaaa tgaaagcatg gaccatgggg      240

gagttggacc atatgaactg ttttgctttt cttcccagtg gcatggaaca ttgtgagaaa      300

tttgaaatct cagaaactag tgtgaacaga gggccagaaa aaatcagacc agaatgtttt      360

gagctacttc gggtacttgg taaagggggc tatggaaagg tttttcaagt acgaaaagta      420

acaggagcaa atactgggaa aatatttgcc atgaaggtgc ttaaaaaggc aatgatagta      480

agaaatgcta aagatacagc tcatacaaaa gcagaacgga atattctgga ggaagtaaag      540

catcccttca tcgtggattt aatttatgcc tttcagactg gtggaaaact ctacctcatc      600

cttgagtatc tcagtggagg agaactattt atgcagttag aaagagaggg aatatttatg      660

gaagacactg cctgctttta cttggcagaa atctccatgg ctttggggca tttacatcaa      720

aaggggatca tctacagaga cctgaagccg gagaatatca tgcttaatca ccaaggtcat      780

gtgaaactaa cagactttgg actatgcaaa gaatctattc atggtggaac agtcacacac      840

acattttgtg gaacaataga atacatggcc cctgaaatct tgatgagaag tggccacaat      900

cgtgctgtgg attggtggag tttgggagca ttaatgtatg acatgctgac tggagcaccc      960

ccattcactg gggagaatag aaagaaaaca attgacaaaa tcctcagatg taaactcaat     1020

ttgcctccct acctcacaca agaagccaga gatctgctta aaaagctgct gaaaagaaat     1080

gctgcttctc gtctgggagc tggtcctggg gacgctggag aagttcaagc tcatccattc     1140

tttagacaca ttaactggga agaacttctg gctcgaaagg tggagccccc ctttaaacct     1200

ctgttgcaat ctgaagagga tgtaagtcag tttgattcca agtttacacg tcagacacct     1260

gtcgacagcc cagatgactc aactctcagt gaaagtgcca atcaggtctt tctgggtttt     1320

acatatgtgg ctccatctgt acttgaaagt gtgaaagaaa agttttcctt tgaaccaaaa     1380

atccgatcac ctcgaagatt tattggcagc ccacgaacac ctgtcagccc agtcaaattt     1440

tctcctgggg atttctgggg aagaggtgct tcggccagca cagcaaatcc tcagacacct     1500

gtggaatacc caatggaaac aagtggcata gagcagatgg atgtgacaat gagtggggaa     1560

gcatcggcac cacttccaat acgacagccg aactctgggc catacaaaaa acaagctttt     1620

cccatgatct ccaaacggcc agagcacctg cgtatgaatc tatgacagag caatgctttt     1680

aatgaattta aggcaaaaaa ggtggagagg gagatgtgtg agcatcctgc aaggtgaaac     1740

gactcaaaat gacagtttca gagagtcaat gtcattacat agaacacttc agacacagga     1800

aaaataaacg tggattttaa aaaatcaatc aatggtgcaa aaaaaaactt aaagcaaaat     1860

agtattgctg aactcttagg cacatcaatt aattgattcc tcgcgacatc ttctcaacct     1920

tatcaaggat tttcatgttg atgactcgaa actgacagta ttaa                      1964


<210> 24
<211> 525
<212> PRT
<213> Homo sapiens

<400> 24
Met Arg Arg Arg Arg Arg Arg Asp Gly Phe Tyr Pro Ala Pro Asp Phe 
1               5                   10                  15      


Arg Asp Arg Glu Ala Glu Asp Met Ala Gly Val Phe Asp Ile Asp Leu 
            20                  25                  30          


Asp Gln Pro Glu Asp Ala Gly Ser Glu Asp Glu Leu Glu Glu Gly Gly 
        35                  40                  45              


Gln Leu Asn Glu Ser Met Asp His Gly Gly Val Gly Pro Tyr Glu Leu 
    50                  55                  60                  


Gly Met Glu His Cys Glu Lys Phe Glu Ile Ser Glu Thr Ser Val Asn 
65                  70                  75                  80  


Arg Gly Pro Glu Lys Ile Arg Pro Glu Cys Phe Glu Leu Leu Arg Val 
                85                  90                  95      


Leu Gly Lys Gly Gly Tyr Gly Lys Val Phe Gln Val Arg Lys Val Thr 
            100                 105                 110         


Gly Ala Asn Thr Gly Lys Ile Phe Ala Met Lys Val Leu Lys Lys Ala 
        115                 120                 125             


Met Ile Val Arg Asn Ala Lys Asp Thr Ala His Thr Lys Ala Glu Arg 
    130                 135                 140                 


Asn Ile Leu Glu Glu Val Lys His Pro Phe Ile Val Asp Leu Ile Tyr 
145                 150                 155                 160 


Ala Phe Gln Thr Gly Gly Lys Leu Tyr Leu Ile Leu Glu Tyr Leu Ser 
                165                 170                 175     


Gly Gly Glu Leu Phe Met Gln Leu Glu Arg Glu Gly Ile Phe Met Glu 
            180                 185                 190         


Asp Thr Ala Cys Phe Tyr Leu Ala Glu Ile Ser Met Ala Leu Gly His 
        195                 200                 205             


Leu His Gln Lys Gly Ile Ile Tyr Arg Asp Leu Lys Pro Glu Asn Ile 
    210                 215                 220                 


Met Leu Asn His Gln Gly His Val Lys Leu Thr Asp Phe Gly Leu Cys 
225                 230                 235                 240 


Lys Glu Ser Ile His Asp Gly Thr Val Thr His Thr Phe Cys Gly Thr 
                245                 250                 255     


Ile Glu Tyr Met Ala Pro Glu Ile Leu Met Arg Ser Gly His Asn Arg 
            260                 265                 270         


Ala Val Asp Trp Trp Ser Leu Gly Ala Leu Met Tyr Asp Met Leu Thr 
        275                 280                 285             


Gly Ala Pro Pro Phe Thr Gly Glu Asn Arg Lys Lys Thr Ile Asp Lys 
    290                 295                 300                 


Ile Leu Lys Cys Lys Leu Asn Leu Pro Pro Tyr Leu Thr Gln Glu Ala 
305                 310                 315                 320 


Arg Asp Leu Leu Lys Lys Leu Leu Lys Arg Asn Ala Ala Ser Arg Leu 
                325                 330                 335     


Gly Ala Gly Pro Gly Asp Ala Gly Glu Val Gln Ala His Pro Phe Phe 
            340                 345                 350         


Arg His Ile Asn Trp Glu Glu Leu Leu Ala Arg Lys Val Glu Pro Pro 
        355                 360                 365             


Phe Lys Pro Leu Leu Gln Ser Glu Glu Asp Val Ser Gln Phe Asp Ser 
    370                 375                 380                 


Lys Phe Thr Arg Gln Thr Pro Val Asp Ser Pro Asp Asp Ser Thr Leu 
385                 390                 395                 400 


Ser Glu Ser Ala Asn Gln Val Phe Leu Gly Phe Thr Tyr Val Ala Pro 
                405                 410                 415     


Ser Val Leu Glu Ser Val Lys Glu Lys Phe Ser Phe Glu Pro Lys Ile 
            420                 425                 430         


Arg Ser Pro Arg Arg Phe Ile Gly Ser Pro Arg Thr Pro Val Ser Pro 
        435                 440                 445             


Val Lys Phe Ser Pro Gly Asp Phe Trp Gly Arg Gly Ala Ser Ala Ser 
    450                 455                 460                 


Thr Ala Asn Pro Gln Thr Pro Val Glu Tyr Pro Met Glu Thr Ser Gly 
465                 470                 475                 480 


Ile Glu Gln Met Asp Val Thr Met Ser Gly Glu Ala Ser Ala Pro Leu 
                485                 490                 495     


Pro Ile Arg Gln Pro Asn Ser Gly Pro Tyr Lys Lys Gln Ala Phe Pro 
            500                 505                 510         


Met Ile Ser Lys Arg Pro Glu His Leu Arg Met Asn Leu 
        515                 520                 525 


<210> 25
<211> 6300
<212> DNA
<213> Homo sapiens

<400> 25
cggccgcggt ttccaggagg aagcaaggat gctttggaca ctgtgcgtgg cgcctccgcg       60

gagcccccgc gctgccattc ccggccgtcg ctcggtcctc cgctgacggg aagcaggaag      120

tggcggcggg cgtcgcgagc ggtgacatca cgggggcgac ggcggcgaag ggcgggggcg      180

gaggaggagc gagccgggcc ggggggcagc tgcacagtct ccgggatccc caggcctgga      240

ggggggtctg tgcgcggccg gctggctctg ccccgcgtcc ggtcccgagc gggcctccct      300

cgggccagcc cgatgtgacc gagcccagcg gagcctgagc aaggagcggg tccgtcgcgg      360

agccggaggg cgggaggaac atgacatcgc ggagatggtt tcacccaaat atcactggtg      420

tggaggcaga aaacctactg ttgacaagag gagttgatgg cagttttttg gcaaggccta      480

gtaaaagtaa ccctggagac ttcacacttt ccgttagaag aaatggagct gtcacccaca      540

tcaagattca gaacactggt gattactatg acctgtatgg aggggagaaa tttgccactt      600

tggctgagtt ggtccagtat tacatggaac atcacgggca attaaaagag aagaatggag      660

atgtcattga gcttaaatat cctctgaact gtgcagatcc tacctctgaa aggtggtttc      720

atggacatct ctctgggaaa gaagcagaga aattattaac tgaaaaagga aaacatggta      780

gttttcttgt acgagagagc cagagccacc ctggagattt tgttctttct gtgcgcactg      840

gtgatgacaa aggggagagc aatgacggca agtctaaagt gacccatgtt atgattcgct      900

gtcaggaact gaaatacgac gttggtggag gagaacggtt tgattctttg acagatcttg      960

tggaacatta taagaagaat cctatggtgg aaacattggg tacagtacta caactcaagc     1020

agccccttaa cacgactcgt ataaatgctg ctgaaataga aagcagagtt cgagaactaa     1080

gcaaattagc tgagaccaca gataaagtca aacaaggctt ttgggaagaa tttgagacac     1140

tacaacaaca ggagtgcaaa cttctctaca gccgaaaaga gggtcaaagg caagaaaaca     1200

aaaacaaaaa tagatataaa aacatcctgc cctttgatca taccagggtt gtcctacacg     1260

atggtgatcc caatgagcct gtttcagatt acatcaatgc aaatatcatc atgcctgaat     1320

ttgaaaccaa gtgcaacaat tcaaagccca aaaagagtta cattgccaca caaggctgcc     1380

tgcaaaacac ggtgaatgac ttttggcgga tggtgttcca agaaaactcc cgagtgattg     1440

tcatgacaac gaaagaagtg gagagaggaa agagtaaatg tgtcaaatac tggcctgatg     1500

agtatgctct aaaagaatat ggcgtcatgc gtgttaggaa cgtcaaagaa agcgccgctc     1560

atgactatac gctaagagaa cttaaacttt caaaggttgg acaagggaat acggagagaa     1620

cggtctggca ataccacttt cggacctggc cggaccacgg cgtgcccagc gaccctgggg     1680

gcgtgctgga cttcctggag gaggtgcacc ataagcagga gagcatcatg gatgcagggc     1740

cggtcgtggt gcactgcagt gctggaattg gccggacagg gacgttcatt gtgattgata     1800

ttcttattga catcatcaga gagaaaggtg ttgactgcga tattgacgtt cccaaaacca     1860

tccagatggt gcggtctcag aggtcaggga tggtccagac agaagcacag taccgattta     1920

tctatatggc ggtccagcat tatattgaaa cactacagcg caggattgaa gaagagcaga     1980

aaagcaagag gaaagggcac gaatatacaa atattaagta ttctctagcg gaccagacga     2040

gtggagatca gagccctctc ccgccttgta ctccaacgcc accctgtgca gaaatgagag     2100

aagacagtgc tagagtctat gaaaacgtgg gcctgatgca acagcagaaa agtttcagat     2160

gagaaaacct gccaaaactt cagcacagaa atagatgtgg actttcaccc tctccctaaa     2220

aagatcaaga acagacgcaa gaaagtttat gtgaagacag aatttggatt tggaaggctt     2280

gcaatgtggt tgactacctt ttgataagca aaatttgaaa ccatttaaag accactgtat     2340

tttaactcaa caatacctgc ttcccaatta ctcatttcct cagataagaa gaaatcatct     2400

ctacaatgta gacaacatta tattttatag aatttgtttg aaattgagga agcagttaaa     2460

ttgtgcgctg tattttgcag attatgggga ttcaaattct agtaataggc ttttttattt     2520

ttatttttat acccttaacc agtttaattt tttttttcct cattgttggg gatgatgaga     2580

agaaatgatt tgggaaaatt aagtaacaac gacctagaaa agtgagaaca atctcattta     2640

ccatcatgta tccagtagtg gataattcat tttgatggct tctatttttg gccaaatgag     2700

aattaagcca gtgcctgaga ctgtcagaag ttgacctttg cactggcatt aaagagtcat     2760

agaaaaagaa tcatggatat ttatgaatta aggtaagagg tgtggctttt ttttttttct     2820

tttttccagc cgttgaccaa ttatagttcg gctgttgact gagaagtttg tggtgggaaa     2880

acgtttgcca tattttcttt gcatttgaat aattgtcttg tacttagaaa aaaggcgtct     2940

atgaatgacc agtgtttttg gtcgccaaat gttgctgaca aacttatccc aaaactttag     3000

tggcttaaaa aaacctgccc ccaactgtta gtcaatctga gctgggctca gctgggctgt     3060

tcttctgcca gcctgcaggt ggccactcat gtggtcagca ggtcggcgga gagactggga     3120

tggctgggct tctctctctg cctgcagtcc tgagtctctc cttcttcgtg tagtctcttt     3180

cagtggcctg gctggcaggg tagctagacc tctcacatgc agctcagagc tcccaagagc     3240

tcaaaagcag aaatggccag gccttctgaa aacttaagtc cagaattgtc acagtgtccc     3300

ttctacttcc ctctattgat gatgatgatg atgatgatga tgatgatgat gatgatgatg     3360

atggtttttt ctaatcagaa gaaagctggg gtatgccctc tacttactaa acaagtcaca     3420

agcccagctc agattcaaga aaagggtgtg aagtagaggt gcagttaagt ggggggccac     3480

tagtctaaca gacggtcaca accagtgcca tggaaaacca aggatattag caaaagcaga     3540

agttgctagt gaccttggga agccgaagct gcttacagta gctgggacaa gctgaaagtc     3600

agactaagaa ataaagagag ggccttcaag aagcttcctg aatgatttct gctagccctg     3660

agcctatttt tggaaccagc acttggggaa actgatcttg tgaggatgga tgtgtttagg     3720

gacacagggc ttttgagagc agcaccaccc cactggggca tccccagact tgggaaacgt     3780

gactctttct taatgccact gggttttagt caggccacag tgagaaggaa cagccctaac     3840

aggcctccag ccaggttgaa tgagctcatt tttgttgtag ccaaccagta agatttgcta     3900

atgttctaca ttaagtgcct tctccaaaga catccctctt tgcctcatat gttgaatcat     3960

ccagtgcgga tatttcaatg aaaatatcat tggttgactt ttgtgatggt aataatgcta     4020

tggcatcttt gccatgaagt tgtggcctcc ttggattctt ctgactttgg cttctgaaag     4080

gaaggcctag atccagccct ggtggtagtt cctttctgag gtctctcagt cccttgagac     4140

tttggggtag tttggctgcc attctcactg acaaaatgta tatcagcccc cacctccacc     4200

ccccaatatt ccttgaactt tgaattgctt cagaacacag gtgtggcctg aaggtattcc     4260

cttattaggg aagtgtcact gctgtcttct agtcaaactt gtaaagaaaa agattccagt     4320

tcagtatttg cagcaagaag cttgaatgct gttcttttta tcgcattgtt acatcgactc     4380

attctccatt ttgctttggt tttgtcttga cttgacttga ctttgggggt aaagtctttc     4440

accagcacac aagagtttga ttgtacaaat atatcttctg cattaacatc tctgcctgtt     4500

gcttaagatc agttgctttt atactcagaa tggaaatacc tgatcttggc tagttttgtt     4560

ataagatatt gatttcattt agatttccct ccacgaggtc agcaaactat catgttctta     4620

tgtaaactta ggccaaggcc agagttatca tagtccctag gttgctacgg cttatcatgt     4680

gcttggtaaa aggtgatcgc aggttctcag acgagtttac tttacatgag atggaatcag     4740

gcagagaggc tgggatgatg gagaaagctc gaggtgaagt tttaaaaaaa aagttgtgga     4800

aaggaaagtt ccaaagaggt ggtttctgag gaagtcagag cgcccagggc cagagcagtc     4860

agtaatgggt gaatgaggtt gtttggaaag tcggtgtgac agacacatgg atgccatcta     4920

cttctaggtt gctggtgggt attaaatatg cacaatattc catagctcac tgaggatttt     4980

aaaattataa gcataggatt ttatattttg gggtgaaaga attatctggc acattaggta     5040

ttggagttta aaaaaaaagc caaatttcac agtcttaata acttttttta aaaaaaacta     5100

aaaggcgctt catgtccagt gtgtggccct tctgaaactt atggtcatct ctcccactga     5160

aaccaaggtc ttttcaaatg tggctaaatg gggatgagga gacacgggta ggactttctt     5220

ggtgtgtgtg cattctttaa agagccaagt tgcttcgggg aaacagccag gaaaatggtc     5280

aagattattt ttagaggtta ttttattggg gattttaaga actaataaca tcttgagtta     5340

tttttaattc agggggatgt ggaaaggttt gcaattgtca agtgttttgt tgtagcttag     5400

tatccataag ggaaacttag actatagaca taactacaaa gccagtgcag cttttgtttt     5460

ctgtatgttg ttgggggatc aactttcaca catagcaagc acatggcctc cctgatgtca     5520

ggatgccttt gttaggatct gtatttgccc ttaattttgt tgaaatcttt tttccttctt     5580

cctcttgaaa agttccaaaa tatagtttat tgtatctttc atcactaaaa atttgttcct     5640

ttttcactat gggcagttca cacaaggcaa aaactattga acagttggtt ttagtgtgtt     5700

gtataacttt gctgtatatc aaactaattt tgacaagttt tcatcctaag cctcaaatca     5760

tgtaattaat aatttgcctg tttatttatg acctaattgt gattctttta ttaataaaag     5820

ctaatgggaa aaggatccct gattaagctg atgactagac ctacaattaa ttttcctgca     5880

gtatatgaag tattgtacca gagtattaaa agatatgtaa tattttattg ataaatctat     5940

cctttaaaag gaatacgttt taggatgtca tcattttgat gtgaatcatg taaatgttga     6000

taatatgctg tttattatac atttagtgtt tcaagagatt cacttaattg cctttttgcc     6060

cacgtatatt atgtagtcta tttgcaactg ttcttaaaaa aatgacatta aaagaatagt     6120

ttatgtagag aaacattagt ggatgttaat tgtctcccca cctatattta tgggtgttag     6180

cgcaactgct ttgctagttg caaagctgta ttatcagagt aaaagtgtat ttgtaaactg     6240

tatgggaact aaaaattagg aataaaacca ttttcttata tgaaaaaaaa aaaaaaaaaa     6300


<210> 26
<211> 2069
<212> DNA
<213> Homo sapiens

<400> 26
cggccgcggt ttccaggagg aagcaaggat gctttggaca ctgtgcgtgg cgcctccgcg       60

gagcccccgc gctgccattc ccggccgtcg ctcggtcctc cgctgacggg aagcaggaag      120

tggcggcggg cgtcgcgagc ggtgacatca cgggggcgac ggcggcgaag ggcgggggcg      180

gaggaggagc gagccgggcc ggggggcagc tgcacagtct ccgggatccc caggcctgga      240

ggggggtctg tgcgcggccg gctggctctg ccccgcgtcc ggtcccgagc gggcctccct      300

cgggccagcc cgatgtgacc gagcccagcg gagcctgagc aaggagcggg tccgtcgcgg      360

agccggaggg cgggaggaac atgacatcgc ggagatggtt tcacccaaat atcactggtg      420

tggaggcaga aaacctactg ttgacaagag gagttgatgg cagttttttg gcaaggccta      480

gtaaaagtaa ccctggagac ttcacacttt ccgttagaag aaatggagct gtcacccaca      540

tcaagattca gaacactggt gattactatg acctgtatgg aggggagaaa tttgccactt      600

tggctgagtt ggtccagtat tacatggaac atcacgggca attaaaagag aagaatggag      660

atgtcattga gcttaaatat cctctgaact gtgcagatcc tacctctgaa aggtggtttc      720

atggacatct ctctgggaaa gaagcagaga aattattaac tgaaaaagga aaacatggta      780

gttttcttgt acgagagagc cagagccacc ctggagattt tgttctttct gtgcgcactg      840

gtgatgacaa aggggagagc aatgacggca agtctaaagt gacccatgtt atgattcgct      900

gtcaggaact gaaatacgac gttggtggag gagaacggtt tgattctttg acagatcttg      960

tggaacatta taagaagaat cctatggtgg aaacattggg tacagtacta caactcaagc     1020

agccccttaa cacgactcgt ataaatgctg ctgaaataga aagcagagtt cgagaactaa     1080

gcaaattagc tgagaccaca gataaagtca aacaaggctt ttgggaagaa tttgagacac     1140

tacaacaaca ggagtgcaaa cttctctaca gccgaaaaga gggtcaaagg caagaaaaca     1200

aaaacaaaaa tagatataaa aacatcctgc cctttgatca taccagggtt gtcctacacg     1260

atggtgatcc caatgagcct gtttcagatt acatcaatgc aaatatcatc atgcctgaat     1320

ttgaaaccaa gtgcaacaat tcaaagccca aaaagagtta cattgccaca caaggctgcc     1380

tgcaaaacac ggtgaatgac ttttggcgga tggtgttcca agaaaactcc cgagtgattg     1440

tcatgacaac gaaagaagtg gagagaggaa agagtaaatg tgtcaaatac tggcctgatg     1500

agtatgctct aaaagaatat ggcgtcatgc gtgttaggaa cgtcaaagaa agcgccgctc     1560

atgactatac gctaagagaa cttaaacttt caaaggttgg acaagggaat acggagagaa     1620

cggtctggca ataccacttt cggacctggc cggaccacgg cgtgcccagc gaccctgggg     1680

gcgtgctgga cttcctggag gaggtgcacc ataagcagga gagcatcatg gatgcagggc     1740

cggtcgtggt gcactgcagg tgacagctcc tgctgcccct ctaggccaca gcctgtccct     1800

gtctcctagc gcccagggct tgcttttacc tacccactcc tagctcttta actgtaggaa     1860

gaatttaata tctgtttgag gcatagagca actgcattga gggacatttt gatcccaagg     1920

catatttctc ctagacccta cagcactgcc attggccatg gccatggcaa catgctcagt     1980

taaaacagca aagactaagt cagcattatc tctgagtcca ccagaagttg tgcattaaac     2040

aacttcatcc tggaaaaaaa aaaaaaaaa                                       2069


<210> 27
<211> 593
<212> PRT
<213> Homo sapiens

<400> 27
Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala 
1               5                   10                  15      


Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn 
        35                  40                  45              


Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr 
65                  70                  75                  80  


Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile 
                85                  90                  95      


Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu 
        115                 120                 125             


Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser 
145                 150                 155                 160 


Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu 
                165                 170                 175     


Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp 
            180                 185                 190         


Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr 
        195                 200                 205             


Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala 
    210                 215                 220                 


Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr 
225                 230                 235                 240 


Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln 
                245                 250                 255     


Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu 
            260                 265                 270         


Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr 
        275                 280                 285             


Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr 
    290                 295                 300                 


Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn 
305                 310                 315                 320 


Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn 
                325                 330                 335     


Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val 
            340                 345                 350         


Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val 
        355                 360                 365             


Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg 
    370                 375                 380                 


Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu 
385                 390                 395                 400 


Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Thr Glu Arg Thr Val Trp 
                405                 410                 415     


Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro 
            420                 425                 430         


Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser 
        435                 440                 445             


Ile Met Asp Ala Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly 
    450                 455                 460                 


Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Leu Ile Asp Ile Ile Arg 
465                 470                 475                 480 


Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pro Lys Thr Ile Gln Met 
                485                 490                 495     


Val Arg Ser Gln Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Arg 
            500                 505                 510         


Phe Ile Tyr Met Ala Val Gln His Tyr Ile Glu Thr Leu Gln Arg Arg 
        515                 520                 525             


Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gly His Glu Tyr Thr Asn 
    530                 535                 540                 


Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gly Asp Gln Ser Pro Leu 
545                 550                 555                 560 


Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Glu Met Arg Glu Asp Ser 
                565                 570                 575     


Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gln Gln Gln Lys Ser Phe 
            580                 585                 590         


Arg 
    


<210> 28
<211> 460
<212> PRT
<213> Homo sapiens

<400> 28
Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala 
1               5                   10                  15      


Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn 
        35                  40                  45              


Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr 
65                  70                  75                  80  


Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile 
                85                  90                  95      


Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu 
        115                 120                 125             


Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser 
145                 150                 155                 160 


Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu 
                165                 170                 175     


Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp 
            180                 185                 190         


Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr 
        195                 200                 205             


Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala 
    210                 215                 220                 


Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr 
225                 230                 235                 240 


Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln 
                245                 250                 255     


Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu 
            260                 265                 270         


Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr 
        275                 280                 285             


Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr 
    290                 295                 300                 


Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn 
305                 310                 315                 320 


Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn 
                325                 330                 335     


Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val 
            340                 345                 350         


Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val 
        355                 360                 365             


Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg 
    370                 375                 380                 


Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu 
385                 390                 395                 400 


Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Thr Glu Arg Thr Val Trp 
                405                 410                 415     


Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro 
            420                 425                 430         


Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser 
        435                 440                 445             


Ile Met Asp Ala Gly Pro Val Val Val His Cys Arg 
    450                 455                 460 


